MCID: CRV002
MIFTS: 40

Cervix Uteri Carcinoma in Situ

Categories: Cancer diseases

Aliases & Classifications for Cervix Uteri Carcinoma in Situ

MalaCards integrated aliases for Cervix Uteri Carcinoma in Situ:

Name: Cervix Uteri Carcinoma in Situ 12 14
Carcinoma in Situ of Uterine Cervix 12 69
Cervical Intraepithelial Neoplasia 41 69
Cervical Intraepithelial Neoplasia Grade Iii with Severe Dysplasia 12
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7 69
Squamous Intraepithelial Neoplasia, Grade Iii 12
Cin Iii - Carcinoma in Situ of Cervix 12
Severe Dysplasia of the Cervix Uteri 12
Cin Iii - Severe Dyskaryosis 12
Carcinoma in Situ of Cervix 12
Carcinoma of Cervix Stage 0 12
Severe Dysplasia of Cervix 12
Cervix Ca in Situ 12
Cin Iii 12

Classifications:



Summaries for Cervix Uteri Carcinoma in Situ

MalaCards based summary : Cervix Uteri Carcinoma in Situ, also known as carcinoma in situ of uterine cervix, is related to cervicitis and cervical intraepithelial neoplasia. An important gene associated with Cervix Uteri Carcinoma in Situ is SERPIND1 (Serpin Family D Member 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Oncogene Induced Senescence. The drugs Cervarix and Gardasil have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related phenotype is mortality/aging.

Related Diseases for Cervix Uteri Carcinoma in Situ

Diseases related to Cervix Uteri Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 cervicitis 30.6 CDKN2A SERPIND1
2 cervical intraepithelial neoplasia 29.8 CDKN2A FHIT KRT17
3 cervical cancer 29.6 CDKN2A FHIT TP53
4 balanoposthitis 10.4 CDKN2A GP6
5 brain stem astrocytic neoplasm 10.4 CDKN2A TP53
6 squamous cell carcinoma of the oropharynx 10.4 CDKN2A TP53
7 spitz nevus 10.4 CDKN2A TP53
8 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
9 squamous cell carcinoma of the larynx 10.4 CDKN2A TP53
10 bartholin's gland benign neoplasm 10.4 CDKN2A TP53
11 bladder carcinoma in situ 10.4 CDKN2A TP53
12 anal squamous cell carcinoma 10.4 CDKN2A TP53
13 thyroid lymphoma 10.4 CDKN2A TP53
14 vulva squamous cell carcinoma 10.4 CDKN2A TP53
15 nasal cavity adenocarcinoma 10.4 CDKN2A TP53
16 bone squamous cell carcinoma 10.4 CDKN2A TP53
17 scrotal carcinoma 10.4 CDKN2A TP53
18 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
19 eccrine sweat gland neoplasm 10.3 KRT17 TP53
20 oral leukoplakia 10.3 CDKN2A TP53
21 balanitis xerotica obliterans 10.3 CDKN2A TP53
22 small cell neuroendocrine carcinoma 10.3 CDKN2A TP53
23 meningeal melanomatosis 10.3 CDKN2A TP53
24 dedifferentiated liposarcoma 10.3 CDKN2A TP53
25 bladder squamous cell carcinoma 10.3 CDKN2A TP53
26 esophagus adenocarcinoma 10.3 CDKN2A TP53
27 cervical adenosarcoma 10.3 GP5 GP6
28 endocervical adenocarcinoma 10.3 CDKN2A TP53
29 small cell sarcoma 10.3 CDKN2A TP53
30 cervix small cell carcinoma 10.3 CDKN2A TP53
31 chronic cervicitis 10.3 CDKN2A GP6 SERPIND1
32 necrotizing sialometaplasia 10.3 CDKN2A TP53
33 cervix disease 10.3 CDKN2A GP6 SERPIND1
34 biliary tract neoplasm 10.3 CDKN2A TP53
35 inverted papilloma 10.3 CDKN2A TP53
36 optic nerve neoplasm 10.2 CDKN2A TP53
37 cellular schwannoma 10.2 CDKN2A TP53
38 cervical clear cell adenocarcinoma 10.2 CDKN2A GP5
39 vulva cancer 10.2 CDKN2A TP53
40 anogenital venereal wart 10.2 CDKN2A GP6 TP53
41 oropharynx cancer 10.2 CDKN2A GP6 TP53
42 mucinous adenocarcinoma 10.2 CDKN2A TP53
43 basaloid squamous cell carcinoma 10.2 CDKN2A KRT17 TP53
44 actinic keratosis 10.1 CDKN2A KRT17 TP53
45 cervical squamous cell carcinoma 10.1 CDKN2A KRT17 TP53
46 juvenile pilocytic astrocytoma 10.1 CDKN2A TP53
47 keratosis 10.1 CDKN2A KRT17 TP53
48 oral squamous cell carcinoma 10.1 CDKN2A KRT17 TP53
49 gastrointestinal system benign neoplasm 10.1 CDKN2A TP53
50 early invasive cervical adenocarcinoma 10.1 CDKN2A INSM1

Comorbidity relations with Cervix Uteri Carcinoma in Situ via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Myofibroma

Graphical network of the top 20 diseases related to Cervix Uteri Carcinoma in Situ:



Diseases related to Cervix Uteri Carcinoma in Situ

Symptoms & Phenotypes for Cervix Uteri Carcinoma in Situ

MGI Mouse Phenotypes related to Cervix Uteri Carcinoma in Situ:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 CDKN2A CINP COL27A1 FHIT GP6 INSM1

Drugs & Therapeutics for Cervix Uteri Carcinoma in Situ

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cervarix 17 45 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
2
Gardasil 17 45 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006

Search Clinical Trials , NIH Clinical Center for Cervix Uteri Carcinoma in Situ

Cochrane evidence based reviews: cervical intraepithelial neoplasia

Genetic Tests for Cervix Uteri Carcinoma in Situ

Anatomical Context for Cervix Uteri Carcinoma in Situ

MalaCards organs/tissues related to Cervix Uteri Carcinoma in Situ:

38
Cervix

Publications for Cervix Uteri Carcinoma in Situ

Articles related to Cervix Uteri Carcinoma in Situ:

(show top 50) (show all 804)
# Title Authors Year
1
Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging. ( 29446041 )
2018
2
Early and late pregnancy outcomes in women treated with cold-coagulation versus LLETZ cervical treatment for cervical intraepithelial neoplasia; a retrospective cohort study. ( 29404740 )
2018
3
Depth of Cervical Intraepithelial Neoplasia Grade 3 in Peruvian Women: Implications for Therapeutic Depth of Necrosis. ( 29271853 )
2018
4
Diagnostic value of human papillomavirus (HPV) 16 and HPV18 viral loads for the detection of high-grade cervical intraepithelial neoplasia (CIN2+) in a cohort of African women living with HIV. ( 29353074 )
2018
5
Safety and tolerance of cidofovir as a 2% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation. ( 29319498 )
2018
6
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ( 29431861 )
2018
7
Low recurrence rate of high-grade cervical intraepithelial neoplasia after successful excision and routine colposcopy during follow-up. ( 29369205 )
2018
8
Prevalence of high-grade cervical intraepithelial neoplasia in women with persistent high-risk HPV genotypes and negative cytology. ( 29350424 )
2018
9
Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization. ( 29400020 )
2018
10
Clinical outcomes after conservative management of cervical intraepithelial neoplasia grade 2 (CIN2) in women ages 21-39 years. ( 29437696 )
2018
11
Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order. ( 29319946 )
2018
12
Risk of preterm birth in women with cervical intraepithelial neoplasia grade one: a population-based cohort study. ( 29165793 )
2018
13
Diagnostic and Treatment Reproducibility of Cervical Intraepithelial Neoplasia / Squamous Intraepithelial Lesion and Factors Affecting the Diagnosis. ( 28832077 )
2017
14
Expressions of programmed death (PD)-1 and PD-1 ligand (PD-L1) in cervical intraepithelial neoplasia and cervical squamous cell carcinomas are of prognostic value and associated with human papillomavirus status. ( 28833798 )
2017
15
Translation and cultural adaptation of the Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia (FACIT-CD) to evaluate quality of life in women with cervical intraepithelial neoplasia. ( 28767912 )
2017
16
Development of a goat model for evaluation of withaferin A: Cervical implants for the treatment of cervical intraepithelial neoplasia. ( 29157955 )
2017
17
Discrepant HPV/cytology cotesting results: Are there differences between cytology-negative versus HPV-negative cervical intraepithelial neoplasia? ( 28817235 )
2017
18
Long-term risk of cervical cancer following conization of cervical intraepithelial neoplasia grade 3-A Danish nationwide cohort study. ( 29218720 )
2017
19
A prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2, based on simple clinical parameters. ( 27697590 )
2017
20
Comparison of the sensitivity and specificity of p16/Ki-67 dual staining and HPV DNA testing of abnormal cervical cytology in the detection of histology proven cervical intraepithelial neoplasia grade 2 and above (CIN 2+). ( 29279588 )
2017
21
Type-Dependent Association between Risk of Cervical Intraepithelial Neoplasia and Viral Load of Oncogenic Human Papillomavirus Types Other than Types 16 and 18. ( 28052328 )
2017
22
Influence of co-infection complicated with human papillomavirus on cervical intraepithelial neoplasia development in patients with atypical squamous cells of undetermined significance. ( 28923300 )
2017
23
A retrospective analysis on 1901 women with high grade cervical intraepithelial neoplasia by colposcopic biopsy. ( 28850822 )
2017
24
Validity Parameters of the Human Papillomavirus Detection Test Hybrid Capture 2 With and Without Cytology After Laser Destruction and Large Loop Excision of the Transformation Zone Treatment of High-Grade Cervical Intraepithelial Neoplasia Lesions. ( 28953121 )
2017
25
Cervical intraepithelial neoplasia (CIN) 3-like squamous cell carcinoma of the cervix: a review of 14 cases with comparison of E-cadherin and cyclin D1 expression in the CIN 3-like and infiltrative tumour elements. ( 27681166 )
2017
26
The Neutrophil-Lymphocyte Ratio Predicts Recurrence of Cervical Intraepithelial Neoplasia. ( 28819422 )
2017
27
The impact of bivalent HPV vaccine on cervical intraepithelial neoplasia by deprivation in Scotland: reducing the gap. ( 28756395 )
2017
28
Digital Colposcopy With Dynamic Spectral Imaging for Detection of Cervical Intraepithelial Neoplasia 2+ in Low-Grade Referrals: The IMPROVE-COLPO Study. ( 28953107 )
2017
29
Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer. ( 28785305 )
2017
30
Authors' reply re: Assessing cervical intraepithelial neoplasia as an indicator disease for HIV in a low endemic setting: a population-based register study. ( 28921796 )
2017
31
Expression of p16INK4A Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix. ( 29207716 )
2017
32
Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome. ( 28705710 )
2017
33
Perceived cervical cancer risk among women treated for high-grade cervical intraepithelial neoplasia: The importance of specific knowledge. ( 29272293 )
2017
34
Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis. ( 28812024 )
2017
35
Nanomechanical Characteristics of Cervical Cancer and Cervical Intraepithelial Neoplasia Revealed by Atomic Force Microscopy. ( 28859048 )
2017
36
Type-specific human papillomavirus prevalence in cervical intraepithelial neoplasia and cancer in Iran. ( 28786495 )
2017
37
Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia. ( 28044307 )
2017
38
Lower Incidence of Cervical Intraepithelial Neoplasia among Young Women with Human Papillomavirus Vaccination in Miyagi, Japan. ( 29269635 )
2017
39
A pilot study on Hla-G locus control region haplotypes and cervical intraepithelial neoplasias. ( 27998803 )
2017
40
Loop Electrosurgical Excision Procedure<i>vs</i>. Cold Knife Cone in Treatment of Cervical Intraepithelial Neoplasia: Review of 447 Cases. ( 29263039 )
2017
41
Increased Cervical HIV RNA Shedding Among HIV-Infected Women Randomized to Loop Electrosurgical Excision Procedure (LEEP) compared to Cryotherapy for Cervical Intraepithelial Neoplasia 2/3. ( 29272368 )
2017
42
Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial. ( 28050798 )
2017
43
Bacterial Vaginosis and Cervical Intraepithelial Neoplasia: Is there an Association or is Co-Existence Incidental? ( 28610416 )
2017
44
Cryotherapy reduces progression of cervical intraepithelial neoplasia grade 1 in South African HIV-infected women: a randomized, controlled trial. ( 28902073 )
2017
45
LINE-1 hypermethylation in white blood cell DNA is associated with high-grade cervical intraepithelial neoplasia. ( 28854904 )
2017
46
Re: Assessing cervical intraepithelial neoplasia as an indicator disease for HIV in a low endemic setting: a population-based register study. ( 28921789 )
2017
47
The use of cold coagulation for the treatment of cervical intraepithelial neoplasia. ( 28737306 )
2017
48
Silent High Grade Cervical Intraepithelial Neoplasia in Atypical Smears from Liquid Based Cervical Cytology - Three Years Experience in Thammasat University Hospital. ( 27797243 )
2016
49
Obstetric complications after treatment of cervical intraepithelial neoplasia. ( 27487072 )
2016
50
Evaluation of careHPV, Cervista Human Papillomavirus, and Hybrid Capture 2 Methods in Diagnosing Cervical Intraepithelial Neoplasia Grade 2+ in Xinjiang Uyghur Women. ( 27317575 )
2016

Variations for Cervix Uteri Carcinoma in Situ

Expression for Cervix Uteri Carcinoma in Situ

Search GEO for disease gene expression data for Cervix Uteri Carcinoma in Situ.

Pathways for Cervix Uteri Carcinoma in Situ

GO Terms for Cervix Uteri Carcinoma in Situ

Biological processes related to Cervix Uteri Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 GP5 GP6 SERPIND1
2 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.32 FHIT TP53
3 positive regulation of cell cycle arrest GO:0071158 9.16 INSM1 TP53
4 replicative senescence GO:0090399 8.96 CDKN2A TP53
5 hemostasis GO:0007599 8.8 GP5 GP6 SERPIND1

Molecular functions related to Cervix Uteri Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Cervix Uteri Carcinoma in Situ

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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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32 ICD10
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70 UMLS via Orphanet
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