Cervix Uteri Carcinoma in Situ malady

MalaCards: Cervix Uteri Carcinoma in Situ, also known as carcinoma in situ of uterine cervix, is related to adenocarcinoma in situ and hepatocellular carcinoma. An important gene associated with Cervix Uteri Carcinoma in Situ is MRFAP1 (Morf4 family associated protein 1), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Blood Coagulation Signaling Pathways. The drugs carmustine and diethylstilbestrol diphosphate have been mentioned in the context of this disorder. Affiliated tissues include cervix.

Aliases & Descriptions:

cervix uteri carcinoma in situ 6 8 carcinoma in situ of uterine cervix 6 43 cervical intraepithelial neoplasia grade iii with severe dysplasia (disorder) 6 carcinoma in situ of uterine cervix (disorder) 6 squamous intraepithelial neoplasia, grade iii 6 carcinoma of cervix stage 0 (disorder) 6 cin iii - carcinoma in situ of cervix 6 severe dysplasia of the cervix uteri 6 cin iii - severe dyskaryosis 6

carcinoma in situ of cervix 6 severe dysplasia of cervix 6 intraepithelial neoplasia 43 malignant tumor of cervix 43 cervix ca in situ 6 cervix carcinoma 43 severe dysplasia 43 carcinoma 43 cin iii 6

Diseases related to cervix uteri carcinoma in situ by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1231)

id	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma in situ	23.8	GP5, CDKN2A
2	hepatocellular carcinoma	14.3
3	breast carcinoma	13.5
4	renal cell carcinoma	13.4
5	thyroiditis	13.2
6	thyroid carcinoma	12.9
7	ovarian carcinoma	12.7
8	lung carcinoma	12.6
9	prostatitis	12.6
10	esophagitis	12.5
11	chronic cervicitis	12.4	GP5, GP6
12	colon carcinoma	12.4
13	gray platelet syndrome	12.3	GP6, GP5
14	factor v leiden thrombophilia	12.3	GP5, GP6
15	prostate carcinoma	12.3
16	oral squamous cell carcinoma	12.3
17	endometrial carcinoma	12.0
18	esophageal squamous cell carcinoma	12.0
19	nasopharyngitis	11.9
20	hepatitis	11.6
21	laryngitis	11.5
22	dysplasia of cervix	11.5	PAPL, CDKN2A, GP6, GP5
23	cervical carcinoma	11.5
24	rabies	11.5	GP5, GP6, CDKN2A
25	pancreatitis	11.5
26	transitional cell carcinoma	11.4
27	papillary thyroid carcinoma	11.4
28	basal cell carcinoma	11.2
29	pancreatic carcinoma	11.2
30	non-small cell lung carcinoma	11.0
31	bladder carcinoma	11.0
32	squamous cell carcinoma of the head and neck	10.9
33	adenoma	10.8
34	adenocarcinoma	10.7
35	laryngeal squamous cell carcinoma	10.6
36	embryonal carcinoma	10.6
37	esophageal carcinoma	10.6
38	renal carcinoma	10.6
39	small cell carcinoma	10.6
40	hypoxia	10.5
41	laryngeal carcinoma	10.4
42	ductal carcinoma in situ	10.3
43	adenoid cystic carcinoma	10.3
44	adenoiditis	10.3
45	papillary carcinoma	10.3
46	hepatitis b	10.3
47	neuroendocrine carcinoma	10.0
48	hepatitis c	9.9
49	clear cell renal cell carcinoma	9.9
50	merkel cell carcinoma	9.8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to cervix uteri carcinoma in situ:

²²

Genes related to cervix uteri carcinoma in situ according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	MRFAP1	Morf4 family associated protein 1	11.0	Disorders
2	INSM1	insulinoma-associated 1	11.0
3	GP5	glycoprotein V (platelet)	11.0
4	LHX6	LIM homeobox 6	11.0	Disorders
5	KRT80	keratin 80	11.0	Disorders
6	PAPL	iron/zinc purple acid phosphatase-like protein	11.0	Disorders
7	PPP1R7	protein phosphatase 1, regulatory subunit 7	11.0	Disorders
8	MTMR12	myotubularin related protein 12	11.0	Disorders
9	MORF4L2	mortality factor 4 like 2	11.0	Disorders
10	GP6	glycoprotein VI (platelet)	11.0
11	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0

Pathways related to cervix uteri carcinoma in situ according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.3	GP5, GP6
2	Blood Coagulation Signaling Pathways37	9.0	GP5, GP6

Molecular functions related to cervix uteri carcinoma in situ according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen binding	GO:005518	9.3	GP5, GP6