MCID: CHG001
MIFTS: 66

Chagas Disease malady

Infectious diseases, Neuronal diseases categories

Summaries for Chagas Disease

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Chagas disease is caused by a parasite. it is common in latin america but not in the united states. infected blood-sucking bugs, sometimes called kissing bugs, spread it. when the bug bites you, usually on your face, it leaves behind infected waste. you can get the infection if you rub it in your eyes or nose, the bite wound or a cut. the disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. if you notice symptoms, they might include fever flu-like symptoms a rash a swollen eyelid these early symptoms usually go away. however, if you don't treat the infection, it stays in your body. later, it can cause serious intestinal and heart problems. a physical exam and blood tests can diagnose it. you may also need tests to see whether the disease has affected your intestines and heart. medicines can kill the parasite, especially early on. you can also treat related problems. for example, a pacemaker helps with certain heart complications. centers for disease control and prevention

MalaCards: Chagas Disease, also known as american trypanosomiasis, is related to leishmaniasis and dilated cardiomyopathy. An important gene associated with Chagas Disease is CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1), and among its related pathways are PAK Pathway and Neuroscience. The compounds cysteine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are cardiovascular system and vision/eye.

Disease Ontology:8 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily triatominae (family reduviidae), most commonly species belonging to the triatoma, rhodnius, and panstrongylus genera. the symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

NIH Rare Diseases:42 Chagas disease is caused by the parasite, trypanosoma cruzi. when a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. chagas disease is common in latin america but not in the united states. last updated: 3/4/2014

CDC:3 Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

Wikipedia:63 Chagas disease /ˈtʃɑːɡəs/, or American trypanosomiasis, is a tropical parasitic disease caused by... more...

Aliases & Classifications for Chagas Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
chagas disease:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

chagas disease 8 42 10 44 48 33 60
american trypanosomiasis 42 48
chagas' disease with digestive system involvement 8
chagas' disease with nervous system involvement 8
chagas' disease with other organ involvement 8
south american trypanosomiasis 42
new world trypanosomiasis 42
chagas' disease 8


External Ids:

Disease Ontology8 DOID:12140
ICD9CM27 086.2
ICD10 via Orphanet26 B57.0, B57.4, B57.1 B57.2, B57.3, B57.5, more
SNOMED-CT56 54570006, 186817003
SNOMED-CT via Orphanet57 77506005

Related Diseases for Chagas Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chagas Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.8CD4, DHFR, SRM
2dilated cardiomyopathy30.5CALR, NPPB, CHRM2, MYH7, ADRB1
3sleeping sickness30.5GSR, SRM, ODC1
4malaria30.4GSR, SRM, DHFR, DHODH, CD4, NEU1
5myocarditis30.3ADRB1, CD4, NPPB
6hypertension30.2NPPB, ADRB1
7obesity30.2ADRB1
8systemic lupus erythematosus29.9RPLP0, CCR5, CALR, CD4, CD28, ADRB1
9congestive heart failure29.9NPPB, CHRM2, MYH7, ADRB1
10schistosomiasis29.9GSR, CD4, CHRM2, CCR5
11retinitis29.9CD4, RHO
12hepatitis29.9CD4
13lupus erythematosus29.9CALR
14leprosy29.9CD4
15trypanosomiasis10.7
16achalasia10.5
17esophageal disease10.5
18esophagitis10.5
19megacolon10.5
20megaesophagus10.5
21brain disease10.4
22visceral leishmaniasis10.2
23onchocerciasis10.2
24neuronitis10.2
25systolic heart failure10.2
26stroke, ischemic10.1
27cerebritis10.1
28hypertensive heart disease10.1
29colonic disease10.1
30intestinal disease10.1
31liver disease10.1
32placenta disease10.1
33salivary gland disease10.1
34toxoplasmosis10.1
35melanoma10.0ODC1, CCR5, AMD1, CALR, NEU1, RHO
36malignant glioma10.0ODC1, CALR, NEU1, NTRK1, CD4, DHFR
37ipex syndrome10.0CCR5, AMD1, CALR, NEU1, RHO, CD4
38ischemia10.0AMD1, CALR, NPPB, CHRM2, NTRK1, MYH7
39immunodeficiency with hyper igm type 210.0CCR5, RHO, NTRK1, CD4, CD28, DHFR
40asthma10.0CCR5, NEU1, RHO, CHRM2, CD4, CD28
41viral infectious disease10.0CCR5, CALR, NEU1, CHRM2, CD4, CD28
42rheumatoid arthritis10.0CCR5, CALR, RHO, CD4, CD28, DHODH
43congenital heart defect10.0CCR5, NPPB, CHRM2, MYH7, ADRB1, GSR
44cadasil10.0ODC1, CANT1, NPPB, NTRK1, ADRB1, GSR
45leukemia10.0ODC1, NTRK1, CD4, CYP51A1, DHFR
46colon cancer10.0ODC1, AMD1, CALR, NEU1, NTRK1, DHFR
47noonan syndrome10.0CCR5, NPPB, CHRM2, MYH7, ADRB1
48cholera10.0CD4, NTRK1, RHO, NEU1, ODC1
49tuberculosis10.0CALR, CD4, CYP51A1, DHFR, GSR
50myeloma10.0SRM, DHFR, CD28, CD4, NEU1

Graphical network of the top 20 diseases related to Chagas Disease:



Diseases related to chagas disease

Clinical Features for Chagas Disease

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Drugs & Therapeutics for Chagas Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chagas Disease

Drug clinical trials:

Search ClinicalTrials for Chagas Disease

Search NIH Clinical Center for Chagas Disease

Search CenterWatch for Chagas Disease

Genetic Tests for Chagas Disease

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Anatomical Context for Chagas Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Chagas Disease:

32
Heart, Testes, Eye, Colon, Lymph node, T cells, Bone marrow, Bone, Brain, Monocytes, B cells, Salivary gland, Endothelial, Liver, Placenta, Breast, Thymus, Kidney, Skeletal muscle

Animal Models for Chagas Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chagas Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.1GSR, CCR5, CALR, NPPB, NEU1, RHO
2MP:000539110.9NEU1, RHO, CHRM2, NTRK1, CD28, GSR
3MP:000301210.9CCR5, NEU1, RHO, NTRK1, MYH7, CD4
4MP:000536910.7CCR5, CALR, NPPB, NEU1, CHRM2, NTRK1

Publications for Chagas Disease

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Sources:
50PubMed
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Articles related to Chagas Disease:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease. (23451183)
2013
2
Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease. (23810852)
2013
3
Benznidazole prevents endothelial damage in an experimental model of Chagas disease. (23529066)
2013
4
Bradyarrhythmias and pacemaker therapy in dogs with Chagas disease. (23662590)
2013
5
Molecular Population Genetics and Evolution of the Chagas' Disease Vector Triatoma infestans (Hemiptera: Reduviidae). (24403850)
2013
6
Chagas disease in transplantation: time to enter an era of better diagnosis and better outcomes. (24266965)
2013
7
Effects of a marine serine protease inhibitor on viability and morphology of Trypanosoma cruzi, the agent of Chagas disease. (23770204)
2013
8
Benznidazole treatment reduces the induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity in Chagas disease symptomatic patients. (23473453)
2013
9
Parasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasis. (23514419)
2013
10
Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. (23544467)
2013
11
Novel polymerase chain reaction-restriction fragment length polymorphism assay to determine internal transcribed spacer-2 group in the Chagas disease vector, Triatoma dimidiata (Latreille, 1811). (23828007)
2013
12
Chagas disease (American trypanosomiasis) in Mexico: an update. (23643518)
2013
13
Heart failure survival score in patients with Chagas disease: correlation with functional variables. (22513344)
2012
14
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
15
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. (22777048)
2012
16
Public street lights increase house infestation by the Chagas disease vector Triatoma dimidiata. (22558384)
2012
17
Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas' disease. (22902748)
2012
18
Parasympathetic impairment in the preclinical stage of chronic Chagas disease. (23011195)
2012
19
Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease. (22666863)
2012
20
Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes. (22595647)
2012
21
Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients. (22523642)
2012
22
Therapy of chagas disease: implications for levels of prevention. (22523499)
2012
23
Risks of endemicity, morbidity and perspectives regarding the control of Chagas disease in the Amazon Region. (22415251)
2012
24
Population genetic structure of Meccus longipennis (Hemiptera, Reduviidae, Triatominae), vector of Chagas disease in West Mexico. (22142488)
2012
25
Geographic distribution of chagas disease vectors in Brazil based on ecological niche modeling. (22523500)
2012
26
Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure: randomized clinical trial. (23270509)
2012
27
Learned host preference in a Chagas disease vector, Rhodnius prolixus. (22138145)
2012
28
Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVI. (22159626)
2012
29
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. (21496931)
2011
30
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
31
Economic evaluation of Chagas disease screening of pregnant Latin American women and of their infants in a non endemic area. (21396345)
2011
32
Immunoendocrinology of the thymus in Chagas disease. (21952685)
2011
33
After years of neglect, Brazil takes aim at Chagas disease. (21988980)
2011
34
Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease. (21503396)
2011
35
In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease. (21466157)
2011
36
Real-time PCR in HIV/Trypanosoma cruzi coinfection with and without Chagas disease reactivation: association with HIV viral load and CD4 level. (21912712)
2011
37
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. (20429511)
2010
38
Immunological imbalance between IFN-gamma and IL-10 levels in the sera of patients with the cardiac form of Chagas disease. (19274383)
2009
39
Trypanosoma cruzi (Chagas' disease agent) reduces HIV-1 replication in human placenta. (18593480)
2008
40
The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts. (18005706)
2007
41
Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease. (17485260)
2007
42
Placental alkaline phosphatase (PLAP) enzyme activity and binding to IgG in Chagas' disease. (16122790)
2005
43
Eradication of American trypanosomiasis (Chagas' disease): an achievable goal? (15537714)
2004
44
Brain natriuretic peptide and left ventricular dysfunction in Chagas' disease. (12241721)
2002
45
Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy. (12447769)
2002
46
Signs, meanings, and actions associated with Chagas disease]. (11910426)
2002
47
Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. (11306602)
2001
48
Desensitization and sequestration of human m2 muscarinic acetylcholine receptors by autoantibodies from patients with Chagas' disease. (9148906)
1997
49
Duodenogastric reflux in Chagas' disease. (3139377)
1988
50
Interrelationship of endemic goiter and Chagas' disease. (14018685)
1962

Genetic Variations for Chagas Disease

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Expression for genes affiliated with Chagas Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chagas Disease

Search GEO for disease gene expression data for Chagas Disease.

Pathways for genes affiliated with Chagas Disease

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Sources:
51QIAGEN, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Chagas Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Chagas Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cysteine4411.8GSR, ODC1, CCR5, CANT1, CALR, NPPB
2tyrosine4411.6ODC1, CCR5, CANT1, CALR, NPPB, CHRM2
3arginine4411.5ODC1, CCR5, CANT1, CALR, NPPB, RHO
4alanine4411.4CCR5, AMD1, RHO, CHRM2, NTRK1, CD4
5lipid4411.4CALR, NPPB, RHO, NTRK1, MYH7, CD4
6glutamine4411.4ODC1, CCR5, CANT1, CALR, RHO, MYH7
7aspartate4411.4ODC1, CCR5, RHO, NTRK1, DHODH, DHFR
8adenylate4411.4ODC1, CANT1, CALR, CHRM2, NTRK1, DHFR
9calcium44 49 11 2414.4NPPB, CALR, CANT1, CCR5, CHRM2, NTRK1
10nitric oxide44 11 2413.4ODC1, AMD1, CANT1, CALR, NPPB, CHRM2
11threonine4411.3CCR5, CALR, RHO, CHRM2, NTRK1, MYH7
12histamine44 28 2413.3ODC1, CCR5, CALR, NPPB, NEU1, RHO
13retinoic acid44 2412.3ODC1, CCR5, CALR, NEU1, RHO, NTRK1
14genistein44 28 59 2 11 2416.3ODC1, CANT1, NPPB, NTRK1, CD4, CD28
15lactate4411.3ODC1, CANT1, CALR, NPPB, NTRK1, DHFR
16gtp44 2812.3ODC1, CANT1, CALR, RHO, CHRM2, CD28
17serine4411.3CCR5, AMD1, NEU1, MYH7, CD4, ADRB1
18guanylate4411.3CANT1, NPPB, RHO, CD28, DHODH, ADRB1
19heparin44 28 11 2414.3CCR5, CANT1, CALR, NEU1, RHO, CD4
20valine4411.3ODC1, CCR5, RHO, MYH7, DHFR, ADRB1
21oxygen44 2412.3CANT1, CALR, NTRK1, CD28, CYP51A1, ADRB1
22glutamate4411.2RHO, NTRK1, MYH7, ADRB1
23isoproterenol44 1112.1ODC1, NPPB, CHRM2, MYH7, ADRB1
24dopamine44 28 11 2414.1ADRB1, NTRK1, NPPB, ODC1
25guanine44 11 2413.1CCR5, RHO, CHRM2, MYH7, ADRB1
26hydrogen44 2412.1CALR, NPPB, RHO, CYP51A1, DHODH
27cyclic amp44 2412.1CCR5, CANT1, CHRM2, NTRK1, CD28, ADRB1
28epinephrine44 11 2413.1CANT1, NPPB, RHO, ADRB1, GSR
29spermine44 28 11 2414.1SRM, CALR, AMD1, ODC1
30opiate4411.1CCR5, RHO, CHRM2, NTRK1
31cadaverine44 2412.1ODC1, AMD1, SRM
32tunicamycin44 5912.0DHFR, CD4, NEU1, CALR
33bisoprolol44 49 1113.0NPPB, CHRM2, ADRB1
34zidovudine44 1112.0DHFR, CD4, NEU1, CCR5
35trypanothione44 1112.0ODC1, SRM, GSR
36polysaccharide4411.0CCR5, CALR, NEU1, RHO, CD4
37atp44 2812.0RPLP0, CANT1, CALR, NPPB, NTRK1, MYH7
385-methylthioadenosine4411.0SRM, DHFR, ODC1
39h2o24410.9ODC1, CALR, NEU1, NTRK1, DHFR, GSR
40acetylcholine44 49 28 11 2414.9NPPB, NEU1, RHO, CHRM2, NTRK1
41estrogen4410.9NPPB
42abeado4410.9ODC1, AMD1
43ethylglyoxal-bis-guanylhydrazone4410.9ODC1, AMD1
441-aminooxy-3-aminopropane4410.8ODC1, SRM
45dfmo44 59 2812.8SRM, AMD1, ODC1
46monobromobimane4410.8RHO, GSR
47cocaine44 1111.7ODC1, CCR5, CHRM2, GSR
48con a4410.7CD28, NEU1, CALR
49methylglyoxal bis(guanylhydrazone)4410.5ODC1, AMD1
50putrescine44 28 11 2413.4SRM, AMD1, ODC1

GO Terms for genes affiliated with Chagas Disease

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Sources:
16Gene Ontology
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Cellular components related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.8RHO, CHRM2, NTRK1, CD28, ADRB1, CCR5
2external side of plasma membraneGO:00989710.4CD28, CD4, CALR, CCR5

Biological processes related to Chagas Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1polyamine metabolic processGO:00659510.8SRM, AMD1, ODC1
2small molecule metabolic processGO:04428110.8ODC1, AMD1, NEU1, CYP51A1, DHODH, SRM
3cell surface receptor signaling pathwayGO:00716610.8CCR5, NPPB, CD4, CD28
4spermidine biosynthetic processGO:00829510.7SRM, AMD1
5viral processGO:01603210.7CD28, CD4, CCR5, RPLP0
6entry into host cellGO:03026010.6CD4, CCR5
7positive regulation of interleukin-2 biosynthetic processGO:04508610.3CD28, CD4

Molecular functions related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.6CD28, CD4, CCR5

Products for genes affiliated with Chagas Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chagas Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet