MCID: CHG001
MIFTS: 66

Chagas Disease malady

Infectious diseases, Neuronal diseases categories

Summaries for Chagas Disease

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Chagas disease is caused by a parasite. it is common in latin america but not in the united states. infected blood-sucking bugs, sometimes called kissing bugs, spread it. when the bug bites you, usually on your face, it leaves behind infected waste. you can get the infection if you rub it in your eyes or nose, the bite wound or a cut. the disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. if you notice symptoms, they might include fever flu-like symptoms a rash a swollen eyelid these early symptoms usually go away. however, if you don't treat the infection, it stays in your body. later, it can cause serious intestinal and heart problems. a physical exam and blood tests can diagnose it. you may also need tests to see whether the disease has affected your intestines and heart. medicines can kill the parasite, especially early on. you can also treat related problems. for example, a pacemaker helps with certain heart complications. centers for disease control and prevention

MalaCards: Chagas Disease, also known as american trypanosomiasis, is related to leishmaniasis and dilated cardiomyopathy. An important gene associated with Chagas Disease is CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1), and among its related pathways are PAK Pathway and Neuroscience. The compounds cysteine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are cardiovascular system and vision/eye.

Disease Ontology:8 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily triatominae (family reduviidae), most commonly species belonging to the triatoma, rhodnius, and panstrongylus genera. the symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

NIH Rare Diseases:42 Chagas disease is caused by the parasite, trypanosoma cruzi. when a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. chagas disease is common in latin america but not in the united states. last updated: 3/4/2014

CDC:3 Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

Wikipedia:63 Chagas disease /ˈtʃɑːɡəs/, or American trypanosomiasis, is a tropical parasitic disease caused by... more...

Aliases & Classifications for Chagas Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
chagas disease:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

chagas disease 8 42 10 44 48 33 60
american trypanosomiasis 42 48
chagas' disease with digestive system involvement 8
chagas' disease with nervous system involvement 8
chagas' disease with other organ involvement 8
south american trypanosomiasis 42
new world trypanosomiasis 42
chagas' disease 8


External Ids:

Disease Ontology8 DOID:12140
ICD9CM27 086.2
ICD10 via Orphanet26 B57.0, B57.4, B57.1 B57.2, B57.3, B57.5, more
SNOMED-CT56 54570006, 186817003
SNOMED-CT via Orphanet57 77506005

Related Diseases for Chagas Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chagas Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.8CD4, DHFR, SRM
2dilated cardiomyopathy30.5CALR, NPPB, CHRM2, MYH7, ADRB1
3sleeping sickness30.5GSR, SRM, ODC1
4malaria30.4GSR, SRM, DHFR, DHODH, CD4, NEU1
5myocarditis30.3ADRB1, CD4, NPPB
6hypertension30.2NPPB, ADRB1
7obesity30.2ADRB1
8systemic lupus erythematosus29.9RPLP0, CCR5, CALR, CD4, CD28, ADRB1
9congestive heart failure29.9NPPB, CHRM2, MYH7, ADRB1
10schistosomiasis29.9GSR, CD4, CHRM2, CCR5
11retinitis29.9CD4, RHO
12hepatitis29.9CD4
13lupus erythematosus29.9CALR
14leprosy29.9CD4
15trypanosomiasis10.7
16achalasia10.5
17esophageal disease10.5
18esophagitis10.5
19megacolon10.5
20megaesophagus10.5
21brain disease10.4
22visceral leishmaniasis10.2
23onchocerciasis10.2
24neuronitis10.2
25systolic heart failure10.2
26stroke, ischemic10.1
27cerebritis10.1
28hypertensive heart disease10.1
29colonic disease10.1
30intestinal disease10.1
31liver disease10.1
32placenta disease10.1
33salivary gland disease10.1
34toxoplasmosis10.1
35melanoma10.0ODC1, CCR5, AMD1, CALR, NEU1, RHO
36malignant glioma10.0ODC1, CALR, NEU1, NTRK1, CD4, DHFR
37ipex syndrome10.0CCR5, AMD1, CALR, NEU1, RHO, CD4
38ischemia10.0AMD1, CALR, NPPB, CHRM2, NTRK1, MYH7
39immunodeficiency with hyper igm type 210.0CCR5, RHO, NTRK1, CD4, CD28, DHFR
40asthma10.0CCR5, NEU1, RHO, CHRM2, CD4, CD28
41viral infectious disease10.0CCR5, CALR, NEU1, CHRM2, CD4, CD28
42rheumatoid arthritis10.0CCR5, CALR, RHO, CD4, CD28, DHODH
43congenital heart defect10.0CCR5, NPPB, CHRM2, MYH7, ADRB1, GSR
44cadasil10.0ODC1, CANT1, NPPB, NTRK1, ADRB1, GSR
45leukemia10.0ODC1, NTRK1, CD4, CYP51A1, DHFR
46colon cancer10.0ODC1, AMD1, CALR, NEU1, NTRK1, DHFR
47noonan syndrome10.0CCR5, NPPB, CHRM2, MYH7, ADRB1
48cholera10.0CD4, NTRK1, RHO, NEU1, ODC1
49tuberculosis10.0CALR, CD4, CYP51A1, DHFR, GSR
50myeloma10.0SRM, DHFR, CD28, CD4, NEU1

Graphical network of the top 20 diseases related to Chagas Disease:



Diseases related to chagas disease

Clinical Features for Chagas Disease

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Drugs & Therapeutics for Chagas Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chagas Disease

Drug clinical trials:

Search ClinicalTrials for Chagas Disease

Search NIH Clinical Center for Chagas Disease

Search CenterWatch for Chagas Disease

Genetic Tests for Chagas Disease

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Anatomical Context for Chagas Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Chagas Disease:

32
Heart, Testes, Eye, Colon, Lymph node, T cells, Bone marrow, Bone, Brain, Monocytes, B cells, Placenta, Salivary gland, Liver, Endothelial, Breast, Skeletal muscle, Thymus, Kidney

Animal Models for Chagas Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chagas Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.1GSR, CCR5, CALR, NPPB, NEU1, RHO
2MP:000539110.9NEU1, RHO, CHRM2, NTRK1, CD28, GSR
3MP:000301210.9CCR5, NEU1, RHO, NTRK1, MYH7, CD4
4MP:000536910.7CCR5, CALR, NPPB, NEU1, CHRM2, NTRK1

Publications for Chagas Disease

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Sources:
50PubMed
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Articles related to Chagas Disease:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Serum mediated activation of macrophages reflects TcVac2 vaccine efficacy against Chagas disease. (24421046)
2014
2
The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort Comparative Evaluation Study. (24392177)
2014
3
Pediatric Chagas Disease in Europe: 45 Cases from Spain and Switzerland. (24153010)
2013
4
Laparoscopic Heller myotomy and fundoplication in patients with Chagas' disease achalasia and massively dilated esophagus. (23317615)
2013
5
Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. (23593525)
2013
6
Archaeosomes display immunoadjuvant potential for a vaccine against Chagas disease. (23291939)
2013
7
Seventy years of the Chagas disease BambuA- Project: celebration and perspectives. (24270243)
2013
8
The "obesity paradox" in an elderly population with a high prevalence of Chagas disease: the 10-year follow-up of the BambuA- (Brazil) Cohort Study of Aging. (23058347)
2013
9
Interstitial cells of Cajal: crucial for the development of megacolon in human Chagas' disease? (23810202)
2013
10
Policy implications of the changing epidemiology of Chagas disease and stroke. (23760217)
2013
11
A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention. (24037109)
2013
12
Oral transmission of Chagas disease: typing of Trypanosoma cruzi from five outbreaks occurred in Venezuela shows multiclonal and common infections in patients, vectors and reservoirs. (23567816)
2013
13
Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways. (24330528)
2013
14
Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis. (23799611)
2013
15
Circadian entrainment by light and host in the Chagas disease vector, Triatoma infestans. (24156522)
2013
16
A country bug in the city: urban infestation by the Chagas disease vector Triatoma infestans in Arequipa, Peru. (24171704)
2013
17
Clinical follow-up of responses to treatment with benznidazol in Amazon: a cohort study of acute Chagas disease. (23724050)
2013
18
Surveillance of Chagas disease among at-risk blood donors in Italy: preliminary results from Umberto I Polyclinic in Rome. (24120609)
2013
19
Risk factors and primary prevention of congenital Chagas disease in a nonendemic country. (23097582)
2013
20
Improved completion rates and characterization of drug reactions with an intensive Chagas disease treatment program in rural Bolivia. (24069472)
2013
21
Design or screening of drugs for the treatment of Chagas disease: what shows the most promise? (24079515)
2013
22
Phylogeographic pattern and extensive mitochondrial DNA divergence disclose a species complex within the Chagas disease vector Triatoma dimidiata. (23940678)
2013
23
Vector blood meals and Chagas disease transmission potential, United States. (22469536)
2012
24
In situ expression of regulatory cytokines by heart inflammatory cells in Chagas' disease patients with heart failure. (22811738)
2012
25
Performance of six diagnostic tests to screen for Chagas disease in blood banks andprevalence of Trypanosoma cruzi infection among donors with inconclusive serologyscreening based on the analysis of epidemiological variables. (23049443)
2012
26
Review: surveillance of Chagas disease. (22726647)
2012
27
Chagas disease. With novel paint, chemist aims to vanquish the vinchuca. (22582241)
2012
28
Dimiconin, a novel coagulation inhibitor from the kissing bug, Triatoma dimidiata, a vector of Chagas disease. (22771751)
2012
29
Trypanosoma cruzi paraflagellar rod proteins 2 and 3 contain immunodominant CD8(+) T-cell epitopes that are recognized by cytotoxic T cells from Chagas disease patients. (22750229)
2012
30
Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009. (23295876)
2012
31
The use of IgG antibodies in conventional and non-conventional immunodiagnostic tests for early prognosis after treatment of Chagas disease. (21620855)
2011
32
Clinical course of patients with chronic systolic heart failure due to the association of Chagas disease and systemic arterial hypertension. (21345496)
2011
33
Chronic phase of Chagas disease: why should it be treated? A comprehensive review. (22012216)
2011
34
Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon. (21742069)
2011
35
Esophageal body motility in achalasia and Chagas' disease. (21166733)
2010
36
Nissen fundoplication for the treatment of gastroesophageal reflux disease in patients with Chagas disease without achalasia. (20464134)
2010
37
Increased myeloperoxidase activity and protein nitration are indicators of inflammation in patients with Chagas' disease. (19297613)
2009
38
Ergosterol biosynthesis and drug development for Chagas disease. (19753490)
2009
39
Canine Chagas' disease (American trypanosomiasis) in North America. (19932362)
2009
40
Prognostic value of natriuretic peptides in Chagas' disease: a 3-year follow-up investigation. (18073475)
2008
41
Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells. (17490721)
2007
42
Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients. (16431876)
2006
43
Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide. (15710733)
2005
44
Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. (15761661)
2004
45
Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome. (12585977)
2002
46
Lower esophageal sphincter pressure in idiopathic achalasia and Chagas disease-related achalasia. (11869326)
2001
47
Diversity of Trypanosoma cruzi stocks and clones derived from Chagas disease patients. II. Isozyme and RFLP characterizations. (8617345)
1996
48
Superior vena cava syndrome as a complication of permanent cardiac pacemaker in a patient with Chagas' heart disease. (8122481)
1993
49
Humoral autoimmune response to ribosomal P proteins in chronic Chagas heart disease. (1893622)
1991
50
Response of the lower esophageal sphincter to pentagastrin on patients with megaesophagus secondary to Chagas' disease. (2517711)
1989

Genetic Variations for Chagas Disease

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Expression for genes affiliated with Chagas Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chagas Disease

Search GEO for disease gene expression data for Chagas Disease.

Pathways for genes affiliated with Chagas Disease

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Sources:
51QIAGEN, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Chagas Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Chagas Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cysteine4411.8CD4, GSR, DHFR, DHODH, CD28, MYH7
2tyrosine4411.6CCR5, CALR, CD4, ODC1, CANT1, ADRB1
3arginine4411.5MYH7, GSR, DHFR, ADRB1, ODC1, CCR5
4alanine4411.4NTRK1, CD4, AMD1, RHO, CHRM2, GSR
5lipid4411.4CALR, NPPB, RHO, NTRK1, CD4, CD28
6glutamine4411.4DHFR, ODC1, CANT1, CALR, RHO, MYH7
7aspartate4411.4ADRB1, GSR, DHFR, DHODH, ODC1, CCR5
8adenylate4411.4CANT1, NTRK1, GSR, ADRB1, DHFR, ODC1
9calcium44 49 11 2414.4CD4, NTRK1, CHRM2, ADRB1, NPPB, CALR
10nitric oxide44 11 2413.4AMD1, ADRB1, CHRM2, NTRK1, CANT1, CALR
11threonine4411.3RHO, CALR, CCR5, CHRM2, NTRK1, MYH7
12histamine44 28 2413.3RHO, ODC1, CCR5, CHRM2, NEU1, NPPB
13retinoic acid44 2412.3NEU1, CALR, RHO, ADRB1, DHFR, CCR5
14genistein44 28 59 2 11 2416.3NTRK1, NPPB, CD4, CANT1, CD28, ODC1
15lactate4411.3DHFR, NTRK1, GSR, NPPB, CANT1, CALR
16gtp44 2812.3RHO, CHRM2, CD28, ODC1, ADRB1, CALR
17serine4411.3AMD1, NEU1, CD4, MYH7, CCR5, ADRB1
18guanylate4411.3RHO, CANT1, NPPB, ADRB1, CD28, DHODH
19heparin44 28 11 2414.3CD4, CALR, CCR5, CANT1, RHO, NEU1
20valine4411.3DHFR, RHO, ODC1, MYH7, ADRB1, CCR5
21oxygen44 2412.3CYP51A1, CD28, CANT1, ADRB1, NTRK1, CALR
22glutamate4411.2MYH7, ADRB1, RHO, NTRK1
23isoproterenol44 1112.1NPPB, MYH7, CHRM2, ODC1, ADRB1
24dopamine44 28 11 2414.1ODC1, NTRK1, ADRB1, NPPB
25guanine44 11 2413.1CCR5, RHO, CHRM2, MYH7, ADRB1
26hydrogen44 2412.1CYP51A1, NPPB, RHO, CALR, DHODH
27cyclic amp44 2412.1CCR5, CANT1, CHRM2, CD28, ADRB1, NTRK1
28epinephrine44 11 2413.1ADRB1, RHO, NPPB, GSR, CANT1
29spermine44 28 11 2414.1CALR, AMD1, SRM, ODC1
30opiate4411.1CHRM2, NTRK1, CCR5, RHO
31cadaverine44 2412.1ODC1, SRM, AMD1
32tunicamycin44 5912.0DHFR, CD4, NEU1, CALR
33bisoprolol44 49 1113.0NPPB, CHRM2, ADRB1
34zidovudine44 1112.0CCR5, NEU1, DHFR, CD4
35trypanothione44 1112.0ODC1, GSR, SRM
36polysaccharide4411.0CCR5, CD4, RHO, CALR, NEU1
37atp44 2812.0NTRK1, NPPB, CALR, CANT1, RPLP0, DHODH
385-methylthioadenosine4411.0ODC1, DHFR, SRM
39h2o24410.9DHFR, GSR, NEU1, CALR, NTRK1, ODC1
40acetylcholine44 49 28 11 2414.9RHO, CHRM2, NTRK1, NEU1, NPPB
41estrogen4410.9NPPB
42abeado4410.9AMD1, ODC1
43ethylglyoxal-bis-guanylhydrazone4410.9ODC1, AMD1
44monobromobimane4410.8RHO, GSR
45dfmo44 59 2812.8AMD1, SRM, ODC1
461-aminooxy-3-aminopropane4410.8ODC1, SRM
47putrescine44 28 11 2413.7AMD1, SRM, ODC1
48cocaine44 1111.6ODC1, CCR5, CHRM2, GSR
49methylglyoxal bis(guanylhydrazone)4410.6ODC1, AMD1
50con a4410.4CALR, CD28, NEU1

GO Terms for genes affiliated with Chagas Disease

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Sources:
16Gene Ontology
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Cellular components related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.8RHO, CHRM2, NTRK1, CD28, ADRB1, CCR5
2external side of plasma membraneGO:00989710.4CD28, CD4, CALR, CCR5

Biological processes related to Chagas Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1polyamine metabolic processGO:00659510.8SRM, AMD1, ODC1
2small molecule metabolic processGO:04428110.8ODC1, AMD1, NEU1, CYP51A1, DHODH, SRM
3cell surface receptor signaling pathwayGO:00716610.8CCR5, NPPB, CD4, CD28
4spermidine biosynthetic processGO:00829510.7SRM, AMD1
5viral processGO:01603210.7CD28, CD4, CCR5, RPLP0
6entry into host cellGO:03026010.6CD4, CCR5
7positive regulation of interleukin-2 biosynthetic processGO:04508610.3CD28, CD4

Molecular functions related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.6CD28, CD4, CCR5

Products for genes affiliated with Chagas Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chagas Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet