MCID: CHG001
MIFTS: 63

Chagas Disease malady

Rare diseases, Infectious diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Chagas Disease

About this section


Fully expand this MalaCard
MedlinePlus:33 Chagas disease is caused by a parasite. it is common in latin america but not in the united states. infected blood-sucking bugs, sometimes called kissing bugs, spread it. when the bug bites you, usually on your face, it leaves behind infected waste. you can get the infection if you rub it in your eyes or nose, the bite wound or a cut. the disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. if you notice symptoms, they might include fever flu-like symptoms a rash a swollen eyelid these early symptoms usually go away. however, if you don't treat the infection, it stays in your body. later, it can cause serious intestinal and heart problems. a physical exam and blood tests can diagnose it. you may also need tests to see whether the disease has affected your intestines and heart. medicines can kill the parasite, especially early on. you can also treat related problems. for example, a pacemaker helps with certain heart complications. centers for disease control and prevention

MalaCards based summary: Chagas Disease, also known as american trypanosomiasis, is related to leishmaniasis and myocarditis. An important gene associated with Chagas Disease is ADRB1 (adrenoceptor beta 1), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Human Embryonic Stem Cell Pluripotency. The compounds bisoprolol and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are no phenotypic analysis and muscle.

Disease Ontology:8 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily triatominae (family reduviidae), most commonly species belonging to the triatoma, rhodnius, and panstrongylus genera. the symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

NIH Rare Diseases:42 Chagas disease is caused by the parasite, trypanosoma cruzi. when a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. chagas disease is common in latin america but not in the united states. last updated: 3/4/2014

CDC:3 Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

Wikipedia:65 Chagas disease /?t?????s/, or American trypanosomiasis, is a tropical parasitic disease caused by the... more...

Aliases & Classifications for Chagas Disease

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Chagas Disease, Aliases & Descriptions:

Name: Chagas Disease 8 42 10 44 48 33 62
American Trypanosomiasis 42 48 62
Chagas' Disease with Digestive System Involvement 8 62
Chagas' Disease with Nervous System Involvement 8 62
Chagas' Disease with Other Organ Involvement 8 62
 
Trypanosomiasis, South American 62
South American Trypanosomiasis 42
New World Trypanosomiasis 42
Chagas' Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
chagas disease:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:12140
MeSH34 D014355
ICD9CM27 086.2
SNOMED-CT57 186817003, 54570006
ICD10 via Orphanet26 B57.0, B57.1, B57.2 B57.3, B57.4, B57.5, more
UMLS via Orphanet63 C0041234

Related Diseases for Chagas Disease

About this section

Diseases related to Chagas Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis31.1SRM, DHFR
2myocarditis30.9NPPB, ADRB1
3sleeping sickness30.7SRM, AMD1, ODC1
4dilated cardiomyopathy30.4MYH7, ADRB1, CHRM2, CALR, NPPB
5systemic lupus erythematosus30.1ADRB1, CCR5, CALR, TRB
6congestive heart failure30.1NPPB, CHRM2, ADRB1, MYH7
7schistosomiasis30.0GSR, CCR5, CHRM2
8malaria29.5ODC1, AMD1, NEU1, DHODH, DHFR, SRM
9trypanosomiasis10.7
10achalasia10.5
11esophagitis10.5
12megacolon10.5
13megaesophagus10.5
14idiopathic achalasia10.5
15kawasaki disease10.4TRB, NPPB
16familial restrictive cardiomyopathy10.4NPPB, MYH7
17autonomic dysfunction10.3
18sudden cardiac death multi-gene panels10.3MYH7, NPPB
19hiv/aids10.3
20intestinal volvulus10.3GSR, CALR
21b-cell lymphomas10.2TRB, SRM, NEU1
22rett syndrome10.2GSR, NTRK1
23onchocerciasis10.2
24systolic heart failure10.2
25visceral leishmaniasis10.2
26neuronitis10.2
27dysautonomia10.2
28pulmonary sarcoidosis10.2TRB, CCR5
29aortic valve stenosis10.2MYH7, CCR5, NPPB
30toxoplasmosis10.1
31hypertension10.1
32obesity10.1
33cerebritis10.1
34endotheliitis10.1
35chronic obstructive pulmonary disease10.1NPPB, GSR, CCR5
36acute myocardial infarction10.1NPPB, GSR, ADRB1, MYH7
37primary hyperoxaluria10.1NPPB, GSR, CCR5
38hepatitis c10.1CCR5, CALR, GSR
39hypersensitivity reaction type ii disease10.1TRB, CALR, CCR5, DHODH
40influenza10.1TRB, CALR, CCR5, NEU1
41herpes simplex10.0TRB, DHFR, NEU1
42essential hypertension10.0ADRB1, CCR5, GSR, NPPB
43coronary artery anomaly10.0ADRB1, CCR5, NPPB
44myeloma10.0TRB, SRM, DHFR, NEU1
45myocardial infarction10.0NPPB, GSR, CCR5, ADRB1
46myeloid leukemia10.0NEU1, DHFR, NTRK1, TRB
47hepatitis10.0
48hiv-110.0
49mucocutaneous leishmaniasis10.0
50ascariasis10.0

Graphical network of the top 20 diseases related to Chagas Disease:



Diseases related to chagas disease

Symptoms for Chagas Disease

About this section

Drugs & Therapeutics for Chagas Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Chagas Disease

Search NIH Clinical Center for Chagas Disease

Genetic Tests for Chagas Disease

About this section

Anatomical Context for Chagas Disease

About this section

MalaCards organs/tissues related to Chagas Disease:

32
Heart, Testes, Eye, Colon, Lymph node, T cells, Bone marrow, Bone, Brain, Monocytes, B cells, Liver, Salivary gland, Placenta, Endothelial, Thymus, Skeletal muscle, Kidney, Breast, Neutrophil

Animal Models for Chagas Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Chagas Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4CYP51A1, MYH7, NEU1, ADRB1, CCR5, NTRK1
2MP:00053698.2CYP51A1, NEU1, ADRB1, CHRM2, CCR5, NTRK1
3MP:00053917.9NEU1, CHRM2, CCR5, NTRK1, GSR, RHO
4MP:00107687.6ODC1, AMD1, NEU1, ADRB1, CCR5, NTRK1
5MP:00053857.0TRB, CYP51A1, NEU1, ADRB1, CHRM2, CCR5

Publications for Chagas Disease

About this section

Articles related to Chagas Disease:

(show top 50)    (show all 667)
idTitleAuthorsYear
1
Community-based sampling methods for surveillance of the Chagas disease vector, Triatoma dimidiata (Hemiptera: Reduviidae: Triatominae). (25276934)
2014
2
Phylogeny and niche conservatism in north and central american triatomine bugs (hemiptera: reduviidae: triatominae), vectors of chagas' disease. (25356550)
2014
3
Improvement of the functional capacity is associated with BDNF and autonomic modulation in Chagas disease. (23232458)
2013
4
Chagas disease is a consideration in latino patients. (24364628)
2013
5
Pediatric Chagas Disease in Europe: 45 Cases from Spain and Switzerland. (24153010)
2013
6
Another disappointing result with implantable cardioverter-defibrillator therapy in patients with Chagas disease. (23585252)
2013
7
21-Hydroxylase gene mutant allele CYP21A2*15 strongly linked to the resistant HLA haplotype B*14:02-DRB1*01:02 in chronic Chagas disease. (23376085)
2013
8
Cardiomyocyte dysfunction during the chronic phase of Chagas disease. (23579807)
2013
9
The improbable transmission of Trypanosoma cruzi to human: the missing link in the dynamics and control of Chagas disease. (24244766)
2013
10
South-south cooperation for Chagas disease. (23911378)
2013
11
Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease. (23451183)
2013
12
Anatomy of the spermatophore in triatomines (Hemiptera, Reduviidae, Triatominae) and its applications to the study of Chagas disease vector biology. (23958911)
2013
13
Laparoscopic Heller myotomy and fundoplication in patients with Chagas' disease achalasia and massively dilated esophagus. (23317615)
2013
14
Pharmacokinetics of hydroxymethylnitrofurazone, a promising new prodrug for chagas' disease treatment. (24080661)
2013
15
Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease. (23810852)
2013
16
Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review. (24053276)
2013
17
Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. (23593525)
2013
18
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells. (23253440)
2013
19
VNI cures acute and chronic experimental Chagas disease. (23372180)
2013
20
Prevalence of Chagas disease in Brazil: A systematic review and meta-analysis. (24139912)
2013
21
Heart failure survival score in patients with Chagas disease: correlation with functional variables. (22513344)
2012
22
Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease. (22535000)
2012
23
Is it safe to use a liver graft from a Chagas disease-seropositive donor in a human immunodeficiency virus-positive recipient? A case report addressing a novel challenge in liver transplantation. (22508549)
2012
24
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity. (22672991)
2012
25
Chagas disease in the immunosuppressed host. (22614520)
2012
26
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
27
Different infective forms trigger distinct immune response in experimental Chagas disease. (22412949)
2012
28
Barriers to Testing and Treatment for Chagas Disease among Latino Immigrants in Georgia. (23326646)
2012
29
Discrepancies and consequences of indirect hemagglutination, indirect immunofluorescence and ELISA tests for the diagnosis of Chagas disease. (22634885)
2012
30
Chagas disease in European countries: the challenge of a surveillance system. (21944556)
2011
31
Antitrypanosomal therapy for chronic Chagas' disease. (21991908)
2011
32
Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease. (21548954)
2011
33
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. (21496931)
2011
34
Chagas disease among the Latin American adult population attending in a primary care center in Barcelona, Spain. (21572511)
2011
35
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
36
Screening and treatment of chagas disease in organ transplant recipients in the United States: recommendations from the chagas in transplant working group. (21401868)
2011
37
The use of IgG antibodies in conventional and non-conventional immunodiagnostic tests for early prognosis after treatment of Chagas disease. (21620855)
2011
38
2-DE-based proteomic investigation of the saliva of the Amazonian triatomine vectors of Chagas disease: Rhodnius brethesi and Rhodnius robustus. (21362504)
2011
39
Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy. (21738806)
2011
40
Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010. (21958533)
2011
41
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
42
Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. (21642025)
2011
43
Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. (20359550)
2010
44
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
45
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
46
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? (17204908)
2006
47
Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease. (15845889)
2005
48
Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide. (15710733)
2005
49
Analysis of the T-cell receptor beta-chain variable-region (Vbeta) repertoire in chronic human Chagas' disease. (12366778)
2002
50
Response of the lower esophageal sphincter to pentagastrin on patients with megaesophagus secondary to Chagas' disease. (2517711)
1989

Variations for Chagas Disease

About this section

Expression for genes affiliated with Chagas Disease

About this section
Expression patterns in normal tissues for genes affiliated with Chagas Disease

Search GEO for disease gene expression data for Chagas Disease.

Pathways for genes affiliated with Chagas Disease

About this section

Pathways related to Chagas Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, MYH7
2
Show member pathways
9.7MYH7, NTRK1, NPPB
39.6NTRK1, CCR5, ADRB1
49.4ADRB1, NTRK1, CALR, RHO
59.2SRM, DHFR
6
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
8.9SRM, AMD1, ODC1
7
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
8.9SRM, AMD1, ODC1
8
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
8.5ODC1, SRM, GSR
9
Show member pathways
7.1GSR, SRM, DHFR, DHODH, NEU1, AMD1

Compounds for genes affiliated with Chagas Disease

About this section

Compounds related to Chagas Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1bisoprolol44 50 1112.0CHRM2, ADRB1, NPPB
2ethylglyoxal-bis-guanylhydrazone4410.0AMD1, ODC1
3abeado4410.0ODC1, AMD1
4monobromobimane449.7RHO, GSR
5methylglyoxal bis(guanylhydrazone)449.6ODC1, AMD1
6guanylate449.6DHODH, NPPB, RHO, CANT1, ADRB1
7cgmp44 2810.4CHRM2, CANT1, RHO, NPPB
8opiate449.4CHRM2, RHO, NTRK1, CCR5
9S-Adenosylmethioninamine249.4SRM, AMD1
101-aminooxy-3-aminopropane449.4SRM, ODC1
11hydrogen44 2410.3CALR, RHO, DHODH, AMD1, NPPB, CYP51A1
12cadaverine44 2410.3SRM, ODC1, AMD1
13acetylcholine44 50 28 24 1113.2CHRM2, NTRK1, RHO, NPPB, NEU1
14dfmo44 28 6111.2SRM, AMD1, ODC1
15guanine44 24 1111.2CHRM2, RHO, CCR5, ADRB1, MYH7
16isoproterenol44 1110.2CHRM2, ODC1, MYH7, ADRB1, NPPB
17epinephrine44 24 1111.2NPPB, ADRB1, GSR, RHO, CANT1
18gsno449.1GSR, CANT1, ODC1
19putrescine44 28 24 1112.1SRM, AMD1, ODC1
20glycerol44 24 1111.1MYH7, RHO, NEU1, DHFR
21spermine28 44 24 1112.0CALR, SRM, AMD1, ODC1
225-methylthioadenosine449.0SRM, ODC1, DHFR
23trypanothione44 119.9SRM, GSR, ODC1
24cocaine44 119.8GSR, CHRM2, ODC1, CCR5
25gtp44 289.8CANT1, CALR, CHRM2, ADRB1, ODC1, RHO
26genistein44 28 61 2 24 1113.8CANT1, GSR, NPPB, ODC1, NTRK1
27cyclophosphamide44 50 1110.8NPPB, TRB, GSR, DHFR
28valine448.7CCR5, ODC1, DHFR, ADRB1, MYH7, RHO
29spermidine44 28 24 1111.6ODC1, AMD1, SRM
30dopamine44 28 24 1111.6ODC1, NPPB, RHO, NTRK1, DHFR, ADRB1
31oxygen44 249.6CYP51A1, NPPB, ADRB1, NTRK1, CALR, CANT1
32heparin44 28 24 1111.5NEU1, NPPB, RHO, CANT1, CALR, CCR5
33nitric oxide44 24 1110.5ODC1, NPPB, CANT1, AMD1, CALR, CHRM2
34histamine44 28 2410.4NPPB, NEU1, CCR5, RHO, CALR, ODC1
35lipid448.4NPPB, RHO, GSR, NTRK1, ADRB1, MYH7
36h2o2448.4CALR, NTRK1, GSR, ODC1, NEU1, DHFR
37threonine448.3MYH7, TRB, RHO, CALR, NTRK1, CHRM2
38lactate448.3NPPB, GSR, CANT1, CALR, NTRK1, DHFR
39glutamine448.1ODC1, MYH7, CALR, CANT1, CCR5, DHFR
40retinoic acid44 249.1NEU1, RHO, NTRK1, CCR5, DHFR, ADRB1
41alanine448.0GSR, RHO, CCR5, DHFR, CHRM2, AMD1
42calcium44 50 24 1111.0CCR5, ADRB1, CALR, NTRK1, NPPB, CANT1
43aspartate447.9RHO, NTRK1, GSR, ODC1, ADRB1, DHODH
44adenylate447.9NTRK1, ADRB1, ODC1, CHRM2, DHFR, GSR
45estrogen447.7NTRK1, NPPB, DHFR, GSR, NEU1, ODC1
46tyrosine447.6CANT1, TRB, NPPB, CALR, NTRK1, CCR5
47glutamate447.6ODC1, MYH7, ADRB1, CCR5, NTRK1, CALR
48arginine447.3NPPB, GSR, MYH7, ADRB1, DHFR, CCR5
49serine447.2AMD1, MYH7, NPPB, RHO, ODC1, NTRK1
50cysteine446.7ODC1, GSR, CANT1, CALR, MYH7, NEU1

GO Terms for genes affiliated with Chagas Disease

About this section

Cellular components related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.9RHO, NTRK1, CCR5, CHRM2, ADRB1

Biological processes related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:00719010.0NTRK1, ADRB1
2positive regulation of Ras GTPase activityGO:0323209.9NTRK1, ADRB1
3spermidine biosynthetic processGO:0082959.5SRM, AMD1
4polyamine metabolic processGO:0065959.0SRM, AMD1, ODC1
5cellular nitrogen compound metabolic processGO:0346418.6ODC1, AMD1, SRM
6small molecule metabolic processGO:0442817.5CYP51A1, ODC1, AMD1, NEU1, DHODH, SRM

Products for genes affiliated with Chagas Disease

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Chagas Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet