MCID: CHG001
MIFTS: 54

Chagas Disease malady

Rare diseases, Infectious diseases, Neuronal diseases categories

Aliases & Classifications for Chagas Disease

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Chagas Disease, Aliases & Descriptions:

Name: Chagas Disease 9 41 11 43 47 32 3 60
American Trypanosomiasis 41 47 3
Chagas' Disease with Digestive System Involvement 9 60
Chagas' Disease with Nervous System Involvement 9 60
 
Chagas' Disease with Other Organ Involvement 9 60
South American Trypanosomiasis 41
New World Trypanosomiasis 41
Chagas' Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
chagas disease:
Inheritance: Not applicable; Prevalence: 6-9/10000 (United States); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:12140
MeSH33 D014355
ICD9CM27 086.2
Orphanet47 3386
SNOMED-CT55 54570006, 186817003
ICD10 via Orphanet26 B57.0, B57.1, B57.2 B57.3, B57.4, B57.5, more
UMLS via Orphanet61 C0041234

Summaries for Chagas Disease

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MedlinePlus:32 Chagas disease is caused by a parasite. it is common in latin america but not in the united states. infected blood-sucking bugs, sometimes called kissing bugs, spread it. when the bug bites you, usually on your face, it leaves behind infected waste. you can get the infection if you rub it in your eyes or nose, the bite wound or a cut. the disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. if you notice symptoms, they might include fever flu-like symptoms a rash a swollen eyelid these early symptoms usually go away. however, if you don't treat the infection, it stays in your body. later, it can cause serious intestinal and heart problems. a physical exam and blood tests can diagnose it. you may also need tests to see whether the disease has affected your intestines and heart. medicines can kill the parasite, especially early on. you can also treat related problems. for example, a pacemaker helps with certain heart complications. centers for disease control and prevention

MalaCards based summary: Chagas Disease, also known as american trypanosomiasis, is related to leishmaniasis and myocarditis. An important gene associated with Chagas Disease is ADRB1 (adrenoceptor beta 1), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Human Embryonic Stem Cell Pluripotency. The compounds bisoprolol and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are no phenotypic analysis and muscle.

Disease Ontology:9 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily triatominae (family reduviidae), most commonly species belonging to the triatoma, rhodnius, and panstrongylus genera. the symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

NIH Rare Diseases:41 Chagas disease is caused by the parasite, trypanosoma cruzi. when a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. chagas disease is common in latin america but not in the united states. last updated: 3/4/2014

CDC:3 Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

Wikipedia:63 Chagas disease /?t?????s/, or American trypanosomiasis, is a tropical parasitic disease caused by the... more...

Related Diseases for Chagas Disease

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Diseases related to Chagas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis31.2SRM, DHFR
2myocarditis30.8NPPB, ADRB1
3sleeping sickness30.7SRM, AMD1, ODC1
4dilated cardiomyopathy30.4MYH7, ADRB1, CHRM2, CALR, NPPB
5systemic lupus erythematosus30.1ADRB1, CCR5, CALR, TRB
6congestive heart failure30.1NPPB, CHRM2, ADRB1, MYH7
7coronary artery disease30.0ADRB1, CCR5, NPPB
8schistosomiasis30.0GSR, CCR5, CHRM2
9malaria29.5ODC1, AMD1, NEU1, DHODH, DHFR, SRM
10hiv-129.5DHFR, CCR5, NTRK1, GSR, RHO
11trypanosomiasis10.8
12achalasia10.5
13megacolon10.5
14megaesophagus10.5
15esophagitis10.5
16kawasaki disease10.4TRB, NPPB
17familial restrictive cardiomyopathy10.4NPPB, MYH7
18autonomic dysfunction10.3
19hemorrhage, intracerebral10.3NPPB, GSR
20sudden cardiac death multi-gene panels10.3MYH7, NPPB
21visceral leishmaniasis10.3
22intestinal volvulus10.3GSR, CALR
23b-cell lymphomas10.2TRB, SRM, NEU1
24neuronitis10.2
25onchocerciasis10.2
26systolic heart failure10.2
27dysautonomia10.2
28rett syndrome10.2GSR, NTRK1
29pulmonary sarcoidosis10.2TRB, CCR5
30aortic valve disease 210.2MYH7, CCR5, NPPB
31toxoplasmosis10.2
32obesity10.1
33cerebritis10.1
34right bundle branch block10.1
35endotheliitis10.1
36pulmonary disease, chronic obstructive10.1NPPB, GSR, CCR5
37acute myocardial infarction10.1NPPB, GSR, ADRB1, MYH7
38primary hyperoxaluria10.1NPPB, GSR, CCR5
39hepatitis c10.1CCR5, CALR, GSR
40hypersensitivity reaction type ii disease10.1TRB, CALR, CCR5, DHODH
41influenza10.0TRB, CALR, CCR5, NEU1
42herpes simplex10.0TRB, DHFR, NEU1
43hypertension, essential10.0ADRB1, CCR5, GSR, NPPB
44myeloma10.0TRB, SRM, DHFR, NEU1
45alcohol dependence10.0NEU1, CHRM2, GSR
46myocardial infarction10.0NPPB, GSR, CCR5, ADRB1
47gastroesophageal reflux10.0
48leprosy10.0
49hepatitis10.0
50ascariasis10.0

Graphical network of the top 20 diseases related to Chagas Disease:



Diseases related to chagas disease

Symptoms for Chagas Disease

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Drugs & Therapeutics for Chagas Disease

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Drug clinical trials:

Search ClinicalTrials for Chagas Disease

Search NIH Clinical Center for Chagas Disease

Genetic Tests for Chagas Disease

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Anatomical Context for Chagas Disease

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MalaCards organs/tissues related to Chagas Disease:

31
Heart, Testes, Eye, Colon, Lymph node, T cells, Bone marrow, Bone, Brain, Monocytes, B cells, Skeletal muscle, Liver, Salivary gland, Placenta, Endothelial, Thymus, Kidney, Breast, Neutrophil

Animal Models for Chagas Disease or affiliated genes

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MGI Mouse Phenotypes related to Chagas Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4NTRK1, CCR5, ADRB1, NEU1, MYH7, RHO
2MP:00053698.2CHRM2, NTRK1, CYP51A1, NEU1, NPPB, CALR
3MP:00053917.9RHO, GSR, NTRK1, CCR5, CHRM2, NEU1
4MP:00107687.6CALR, NTRK1, CCR5, ADRB1, NEU1, AMD1
5MP:00053857.0CCR5, TRB, NPPB, RHO, GSR, CALR

Publications for Chagas Disease

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Articles related to Chagas Disease:

(show top 50)    (show all 683)
idTitleAuthorsYear
1
Community-based sampling methods for surveillance of the Chagas disease vector, Triatoma dimidiata (Hemiptera: Reduviidae: Triatominae). (25276934)
2014
2
Phylogeny and niche conservatism in north and central american triatomine bugs (hemiptera: reduviidae: triatominae), vectors of chagas' disease. (25356550)
2014
3
Improvement of the functional capacity is associated with BDNF and autonomic modulation in Chagas disease. (23232458)
2013
4
Chagas disease is a consideration in latino patients. (24364628)
2013
5
Pediatric Chagas Disease in Europe: 45 Cases from Spain and Switzerland. (24153010)
2013
6
Another disappointing result with implantable cardioverter-defibrillator therapy in patients with Chagas disease. (23585252)
2013
7
21-Hydroxylase gene mutant allele CYP21A2*15 strongly linked to the resistant HLA haplotype B*14:02-DRB1*01:02 in chronic Chagas disease. (23376085)
2013
8
Cardiomyocyte dysfunction during the chronic phase of Chagas disease. (23579807)
2013
9
The improbable transmission of Trypanosoma cruzi to human: the missing link in the dynamics and control of Chagas disease. (24244766)
2013
10
South-south cooperation for Chagas disease. (23911378)
2013
11
Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease. (23451183)
2013
12
Anatomy of the spermatophore in triatomines (Hemiptera, Reduviidae, Triatominae) and its applications to the study of Chagas disease vector biology. (23958911)
2013
13
Laparoscopic Heller myotomy and fundoplication in patients with Chagas' disease achalasia and massively dilated esophagus. (23317615)
2013
14
Pharmacokinetics of hydroxymethylnitrofurazone, a promising new prodrug for chagas' disease treatment. (24080661)
2013
15
Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease. (23810852)
2013
16
Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review. (24053276)
2013
17
Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. (23593525)
2013
18
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells. (23253440)
2013
19
VNI cures acute and chronic experimental Chagas disease. (23372180)
2013
20
Heart failure survival score in patients with Chagas disease: correlation with functional variables. (22513344)
2012
21
Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease. (22535000)
2012
22
Triatomines in dwellings and outbuildings in an endemic area of Chagas disease in northeastern Brazil. (23295872)
2012
23
Is it safe to use a liver graft from a Chagas disease-seropositive donor in a human immunodeficiency virus-positive recipient? A case report addressing a novel challenge in liver transplantation. (22508549)
2012
24
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity. (22672991)
2012
25
Chagas disease in the immunosuppressed host. (22614520)
2012
26
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
27
Different infective forms trigger distinct immune response in experimental Chagas disease. (22412949)
2012
28
Barriers to Testing and Treatment for Chagas Disease among Latino Immigrants in Georgia. (23326646)
2012
29
Discrepancies and consequences of indirect hemagglutination, indirect immunofluorescence and ELISA tests for the diagnosis of Chagas disease. (22634885)
2012
30
Chagas disease in European countries: the challenge of a surveillance system. (21944556)
2011
31
Antitrypanosomal therapy for chronic Chagas' disease. (21991908)
2011
32
Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease. (21548954)
2011
33
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. (21496931)
2011
34
Chagas disease among the Latin American adult population attending in a primary care center in Barcelona, Spain. (21572511)
2011
35
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
36
Screening and treatment of chagas disease in organ transplant recipients in the United States: recommendations from the chagas in transplant working group. (21401868)
2011
37
The use of IgG antibodies in conventional and non-conventional immunodiagnostic tests for early prognosis after treatment of Chagas disease. (21620855)
2011
38
2-DE-based proteomic investigation of the saliva of the Amazonian triatomine vectors of Chagas disease: Rhodnius brethesi and Rhodnius robustus. (21362504)
2011
39
Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy. (21738806)
2011
40
Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010. (21958533)
2011
41
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
42
Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. (21642025)
2011
43
Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. (20359550)
2010
44
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
45
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
46
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? (17204908)
2006
47
Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease. (15845889)
2005
48
Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide. (15710733)
2005
49
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
50
Response of the lower esophageal sphincter to pentagastrin on patients with megaesophagus secondary to Chagas' disease. (2517711)
1989

Variations for Chagas Disease

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Expression for genes affiliated with Chagas Disease

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Search GEO for disease gene expression data for Chagas Disease.

Pathways for genes affiliated with Chagas Disease

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Pathways related to Chagas Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, MYH7
2
Show member pathways
9.7NPPB, NTRK1, MYH7
39.6NTRK1, CCR5, ADRB1
49.4RHO, ADRB1, CALR, NTRK1
59.2SRM, DHFR
6
Show member pathways
citrulline-nitric oxide cycle36
arginine degradation I (arginase pathway)36
proline degradation36
glutamine degradation I36
proline biosynthesis I36
superpathway of citrulline metabolism36
proline biosynthesis II (from arginine)36
citrulline biosynthesis36
arginine degradation VI (arginase 2 pathway)36
Urea cycle and metabolism of amino groups36
asparagine biosynthesis I36
4-hydroxyproline degradation I36
citrulline degradation36
8.9AMD1, ODC1, SRM
7
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
8.9SRM, AMD1, ODC1
8
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
8.5ODC1, GSR, SRM
9
Show member pathways
7.1GSR, CYP51A1, ODC1, AMD1, NEU1, DHODH

Compounds for genes affiliated with Chagas Disease

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Compounds related to Chagas Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1bisoprolol43 49 1212.0CHRM2, ADRB1, NPPB
2ethylglyoxal-bis-guanylhydrazone4310.0AMD1, ODC1
3abeado4310.0ODC1, AMD1
4monobromobimane439.7RHO, GSR
5methylglyoxal bis(guanylhydrazone)439.6ODC1, AMD1
6guanylate439.6DHODH, NPPB, RHO, CANT1, ADRB1
7cgmp43 2810.4CHRM2, CANT1, RHO, NPPB
8opiate439.4CHRM2, RHO, NTRK1, CCR5
9S-Adenosylmethioninamine249.4SRM, AMD1
101-aminooxy-3-aminopropane439.4SRM, ODC1
11hydrogen43 2410.3CALR, RHO, DHODH, AMD1, NPPB, CYP51A1
12cadaverine43 2410.3SRM, ODC1, AMD1
13acetylcholine43 49 28 24 1213.2CHRM2, NTRK1, RHO, NPPB, NEU1
14dfmo43 28 5911.2SRM, AMD1, ODC1
15guanine43 24 1211.2CHRM2, RHO, CCR5, ADRB1, MYH7
16isoproterenol43 1210.2CHRM2, ODC1, MYH7, ADRB1, NPPB
17epinephrine43 24 1211.2NPPB, ADRB1, GSR, RHO, CANT1
18gsno439.1GSR, CANT1, ODC1
19putrescine43 28 24 1212.1SRM, AMD1, ODC1
20glycerol43 24 1211.1MYH7, RHO, NEU1, DHFR
21spermine28 43 24 1212.0CALR, SRM, AMD1, ODC1
225-methylthioadenosine439.0SRM, ODC1, DHFR
23trypanothione43 129.9SRM, GSR, ODC1
24cocaine43 129.8GSR, CHRM2, ODC1, CCR5
25gtp43 289.8CANT1, CALR, CHRM2, ADRB1, ODC1, RHO
26genistein43 28 59 2 24 1213.8CANT1, GSR, NPPB, ODC1, NTRK1
27cyclophosphamide43 49 1210.8NPPB, TRB, GSR, DHFR
28valine438.7CCR5, ODC1, DHFR, ADRB1, MYH7, RHO
29spermidine43 28 24 1211.6ODC1, AMD1, SRM
30dopamine43 28 24 1211.6ODC1, NPPB, RHO, NTRK1, DHFR, ADRB1
31oxygen43 249.6CYP51A1, NPPB, ADRB1, NTRK1, CALR, CANT1
32heparin43 28 24 1211.5NEU1, NPPB, RHO, CANT1, CALR, CCR5
33nitric oxide43 24 1210.5ODC1, NPPB, CANT1, AMD1, CALR, CHRM2
34histamine43 28 2410.4NPPB, NEU1, CCR5, RHO, CALR, ODC1
35lipid438.4NPPB, RHO, GSR, NTRK1, ADRB1, MYH7
36h2o2438.4CALR, NTRK1, GSR, ODC1, NEU1, DHFR
37threonine438.3MYH7, TRB, RHO, CALR, NTRK1, CHRM2
38lactate438.3NPPB, GSR, CANT1, CALR, NTRK1, DHFR
39glutamine438.1ODC1, MYH7, CALR, CANT1, CCR5, DHFR
40retinoic acid43 249.1NEU1, RHO, NTRK1, CCR5, DHFR, ADRB1
41alanine438.0GSR, RHO, CCR5, DHFR, CHRM2, AMD1
42calcium43 49 24 1211.0CCR5, ADRB1, CALR, NTRK1, NPPB, CANT1
43aspartate437.9RHO, NTRK1, GSR, ODC1, ADRB1, DHODH
44adenylate437.9NTRK1, ADRB1, ODC1, CHRM2, DHFR, GSR
45estrogen437.7NTRK1, NPPB, DHFR, GSR, NEU1, ODC1
46tyrosine437.6CANT1, TRB, NPPB, CALR, NTRK1, CCR5
47glutamate437.6ODC1, MYH7, ADRB1, CCR5, NTRK1, CALR
48arginine437.3NPPB, GSR, MYH7, ADRB1, DHFR, CCR5
49serine437.2AMD1, MYH7, NPPB, RHO, ODC1, NTRK1
50cysteine436.7ODC1, GSR, CANT1, CALR, MYH7, NEU1

GO Terms for genes affiliated with Chagas Disease

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Cellular components related to Chagas Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.9RHO, NTRK1, CCR5, CHRM2, ADRB1

Biological processes related to Chagas Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:000719010.0ADRB1, NTRK1
2positive regulation of Ras GTPase activityGO:00323209.9ADRB1, NTRK1
3spermidine biosynthetic processGO:00082959.5AMD1, SRM
4polyamine metabolic processGO:00065959.0SRM, AMD1, ODC1
5cellular nitrogen compound metabolic processGO:00346418.6ODC1, AMD1, SRM
6small molecule metabolic processGO:00442817.5AMD1, ODC1, NEU1, DHODH, SRM, GSR

Products for genes affiliated with Chagas Disease

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Sources for Chagas Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet