MCID: CHG001
MIFTS: 62

Chagas Disease malady

Rare diseases, Infectious diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Chagas Disease

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Chagas disease is caused by a parasite. it is common in latin america but not in the united states. infected blood-sucking bugs, sometimes called kissing bugs, spread it. when the bug bites you, usually on your face, it leaves behind infected waste. you can get the infection if you rub it in your eyes or nose, the bite wound or a cut. the disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. if you notice symptoms, they might include fever flu-like symptoms a rash a swollen eyelid these early symptoms usually go away. however, if you don't treat the infection, it stays in your body. later, it can cause serious intestinal and heart problems. a physical exam and blood tests can diagnose it. you may also need tests to see whether the disease has affected your intestines and heart. medicines can kill the parasite, especially early on. you can also treat related problems. for example, a pacemaker helps with certain heart complications. centers for disease control and prevention

MalaCards: Chagas Disease, also known as american trypanosomiasis, is related to leishmaniasis and sleeping sickness. An important gene associated with Chagas Disease is ADRB1 (adrenoceptor beta 1), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Human Embryonic Stem Cell Pluripotency. The compounds bisoprolol and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are no phenotypic analysis and muscle.

Disease Ontology:8 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily triatominae (family reduviidae), most commonly species belonging to the triatoma, rhodnius, and panstrongylus genera. the symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

NIH Rare Diseases:43 Chagas disease is caused by the parasite, trypanosoma cruzi. when a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. chagas disease is common in latin america but not in the united states. last updated: 3/4/2014

CDC:4 Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

Wikipedia:65 Chagas disease /?t?????s/, or American trypanosomiasis, is a tropical parasitic disease caused by the... more...

Aliases & Classifications for Chagas Disease

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
chagas disease:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

chagas disease 8 43 10 45 49 34 62
american trypanosomiasis 43 49
chagas' disease with digestive system involvement 8
chagas' disease with nervous system involvement 8
chagas' disease with other organ involvement 8
south american trypanosomiasis 43
new world trypanosomiasis 43
chagas' disease 8


External Ids:

Disease Ontology8 DOID:12140
ICD9CM27 086.2
ICD10 via Orphanet26 B57.0, B57.4, B57.1 B57.2, B57.3, B57.5, more
SNOMED-CT58 54570006, 186817003
UMLS via Orphanet63 C0041234
SNOMED-CT via Orphanet59 77506005

Related Diseases for Chagas Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chagas Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.9SRM, DHFR
2sleeping sickness30.5SRM, ODC1, AMD1
3dilated cardiomyopathy30.5CHRM2, NPPB, CALR, ADRB1, MYH7
4myocarditis30.4NPPB, ADRB1
5malaria30.2GSR, SRM, DHFR, DHODH, NEU1, AMD1
6systemic lupus erythematosus30.0TRB, CALR, CCR5, ADRB1
7congestive heart failure30.0NPPB, ADRB1, MYH7, CHRM2
8coronary artery disease30.0NPPB, CCR5, ADRB1
9schistosomiasis30.0CHRM2, CCR5, GSR
10trypanosomiasis10.7
11achalasia10.5
12esophagitis10.5
13megacolon10.5
14megaesophagus10.5
15idiopathic achalasia10.5
16autonomic dysfunction10.3
17hiv/aids10.3
18neuronitis10.2
19onchocerciasis10.2
20systolic heart failure10.2
21visceral leishmaniasis10.2
22toxoplasmosis10.1
23cerebritis10.1
24hypertension10.1
25obesity10.1
26dysautonomia10.1
27endotheliitis10.1
28kawasaki disease10.1TRB, NPPB
29familial restrictive cardiomyopathy10.1NPPB, MYH7
30sudden cardiac death multi-gene panels10.1MYH7, NPPB
31intestinal volvulus10.1GSR, CALR
32b-cell lymphomas10.1TRB, NEU1, SRM
33rett syndrome10.1NTRK1, GSR
34pulmonary sarcoidosis10.0CCR5, TRB
35aortic valve stenosis10.0CCR5, NPPB, MYH7
36pulmonary disease, chronic obstructive10.0GSR, CCR5, NPPB
37acute myocardial infarction10.0ADRB1, NPPB, GSR, MYH7
38primary hyperoxaluria10.0NPPB, CCR5, GSR
39hepatitis c10.0CALR, CCR5, GSR
40hypersensitivity reaction type ii disease10.0DHODH, CCR5, CALR, TRB
41influenza10.0NEU1, CCR5, TRB, CALR
42herpes simplex10.0TRB, NEU1, DHFR
43essential hypertension10.0GSR, CCR5, NPPB, ADRB1
44myeloma10.0NEU1, DHFR, SRM, TRB
45myocardial infarction10.0CCR5, ADRB1, NPPB, GSR
46myeloid leukemia10.0NEU1, DHFR, NTRK1, TRB
47diabetes mellitus10.0NEU1, CALR, NPPB, GSR
48gastric ulcer10.0ODC1, GSR
49plasmodium falciparum malaria10.0GSR, DHFR
50chronic kidney failure10.0NPPB, GSR, CCR5, NEU1

Graphical network of the top 20 diseases related to Chagas Disease:



Diseases related to chagas disease

Symptoms for Chagas Disease

About this section

Drugs & Therapeutics for Chagas Disease

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Chagas Disease

Search NIH Clinical Center for Chagas Disease

Genetic Tests for Chagas Disease

About this section

Anatomical Context for Chagas Disease

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chagas Disease:

33
Heart, Testes, Eye, Colon, Lymph node, T cells, Bone marrow, Bone, Brain, Monocytes, B cells, Placenta, Salivary gland, Liver, Endothelial, Breast, Skeletal muscle, Thymus, Kidney

Animal Models for Chagas Disease or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Chagas Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4CYP51A1, MYH7, NEU1, ADRB1, CCR5, NTRK1
2MP:00053698.2CYP51A1, NEU1, ADRB1, CHRM2, CCR5, NTRK1
3MP:00053917.9NEU1, CHRM2, CCR5, NTRK1, GSR, RHO
4MP:00107687.6ODC1, AMD1, NEU1, ADRB1, CCR5, NTRK1
5MP:00053857.0TRB, CYP51A1, NEU1, ADRB1, CHRM2, CCR5

Publications for Chagas Disease

About this section
Sources:
52PubMed
See all sources

Articles related to Chagas Disease:

(show top 50)    (show all 644)
idTitleAuthorsYear
1
Improvement of the functional capacity is associated with BDNF and autonomic modulation in Chagas disease. (23232458)
2013
2
Chagas disease is a consideration in latino patients. (24364628)
2013
3
Pediatric Chagas Disease in Europe: 45 Cases from Spain and Switzerland. (24153010)
2013
4
Another disappointing result with implantable cardioverter-defibrillator therapy in patients with Chagas disease. (23585252)
2013
5
Cardiomyocyte dysfunction during the chronic phase of Chagas disease. (23579807)
2013
6
The improbable transmission of Trypanosoma cruzi to human: the missing link in the dynamics and control of Chagas disease. (24244766)
2013
7
South-south cooperation for Chagas disease. (23911378)
2013
8
Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease. (23451183)
2013
9
Anatomy of the spermatophore in triatomines (Hemiptera, Reduviidae, Triatominae) and its applications to the study of Chagas disease vector biology. (23958911)
2013
10
Laparoscopic Heller myotomy and fundoplication in patients with Chagas' disease achalasia and massively dilated esophagus. (23317615)
2013
11
Pharmacokinetics of hydroxymethylnitrofurazone, a promising new prodrug for chagas' disease treatment. (24080661)
2013
12
Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease. (23810852)
2013
13
Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review. (24053276)
2013
14
Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. (23593525)
2013
15
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells. (23253440)
2013
16
VNI cures acute and chronic experimental Chagas disease. (23372180)
2013
17
Prevalence of Chagas disease in Brazil: A systematic review and meta-analysis. (24139912)
2013
18
Cardiopulmonary exercise and 6-min walk tests as predictors of quality of life and long-term mortality among patients with heart failure due to Chagas disease. (23871619)
2013
19
Heart failure survival score in patients with Chagas disease: correlation with functional variables. (22513344)
2012
20
Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease. (22535000)
2012
21
Triatomines in dwellings and outbuildings in an endemic area of Chagas disease in northeastern Brazil. (23295872)
2012
22
Is it safe to use a liver graft from a Chagas disease-seropositive donor in a human immunodeficiency virus-positive recipient? A case report addressing a novel challenge in liver transplantation. (22508549)
2012
23
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity. (22672991)
2012
24
Chagas disease in the immunosuppressed host. (22614520)
2012
25
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
26
Different infective forms trigger distinct immune response in experimental Chagas disease. (22412949)
2012
27
Barriers to Testing and Treatment for Chagas Disease among Latino Immigrants in Georgia. (23326646)
2012
28
Discrepancies and consequences of indirect hemagglutination, indirect immunofluorescence and ELISA tests for the diagnosis of Chagas disease. (22634885)
2012
29
Chagas disease in European countries: the challenge of a surveillance system. (21944556)
2011
30
Antitrypanosomal therapy for chronic Chagas' disease. (21991908)
2011
31
Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease. (21548954)
2011
32
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. (21496931)
2011
33
Chagas disease among the Latin American adult population attending in a primary care center in Barcelona, Spain. (21572511)
2011
34
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
35
Screening and treatment of chagas disease in organ transplant recipients in the United States: recommendations from the chagas in transplant working group. (21401868)
2011
36
The use of IgG antibodies in conventional and non-conventional immunodiagnostic tests for early prognosis after treatment of Chagas disease. (21620855)
2011
37
2-DE-based proteomic investigation of the saliva of the Amazonian triatomine vectors of Chagas disease: Rhodnius brethesi and Rhodnius robustus. (21362504)
2011
38
Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy. (21738806)
2011
39
Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010. (21958533)
2011
40
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
41
Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. (21642025)
2011
42
Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. (20359550)
2010
43
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
44
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
45
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? (17204908)
2006
46
Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease. (15845889)
2005
47
Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide. (15710733)
2005
48
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
49
Analysis of the T-cell receptor beta-chain variable-region (Vbeta) repertoire in chronic human Chagas' disease. (12366778)
2002
50
Response of the lower esophageal sphincter to pentagastrin on patients with megaesophagus secondary to Chagas' disease. (2517711)
1989

Variations for Chagas Disease

About this section

Expression for genes affiliated with Chagas Disease

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chagas Disease

Search GEO for disease gene expression data for Chagas Disease.

Pathways for genes affiliated with Chagas Disease

About this section
Sources:
50PathCards, 53QIAGEN, 30KEGG, 5Cell Signaling Technology, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters
See all sources

Pathways related to Chagas Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, MYH7
2
Show member pathways
9.7MYH7, NTRK1, NPPB
39.6NTRK1, CCR5, ADRB1
49.4ADRB1, NTRK1, CALR, RHO
59.2SRM, DHFR
6
Show member pathways
citrulline-nitric oxide cycle38
arginine degradation I (arginase pathway)38
proline degradation38
glutamine degradation I38
proline biosynthesis I38
superpathway of citrulline metabolism38
proline biosynthesis II (from arginine)38
citrulline biosynthesis38
arginine degradation VI (arginase 2 pathway)38
Urea cycle and metabolism of amino groups38
asparagine biosynthesis I38
4-hydroxyproline degradation I38
citrulline degradation38
8.9SRM, AMD1, ODC1
7
Show member pathways
creatine-phosphate biosynthesis38
glycine degradation (creatine biosynthesis)38
putrescine biosynthesis III38
spermidine biosynthesis I38
tryptophan degradation via kynurenine38
spermine biosynthesis38
urea cycle38
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I38
tyrosine degradation I38
L-carnitine biosynthesis38
methylthiopropionate biosynthesis38
2-oxoglutarate decarboxylation to succinyl-CoA38
S-methyl-5-thioadenosine degradation II38
8.9SRM, AMD1, ODC1
8
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
8.5ODC1, SRM, GSR
9
Show member pathways
7.1GSR, SRM, DHFR, DHODH, NEU1, AMD1

Compounds for genes affiliated with Chagas Disease

About this section
Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Chagas Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1bisoprolol45 51 1112.0CHRM2, ADRB1, NPPB
2ethylglyoxal-bis-guanylhydrazone4510.0AMD1, ODC1
3abeado4510.0ODC1, AMD1
4monobromobimane459.7RHO, GSR
5methylglyoxal bis(guanylhydrazone)459.6ODC1, AMD1
6guanylate459.6DHODH, NPPB, RHO, CANT1, ADRB1
7cgmp45 2910.4CHRM2, CANT1, RHO, NPPB
8opiate459.4CHRM2, RHO, NTRK1, CCR5
9S-Adenosylmethioninamine249.4SRM, AMD1
101-aminooxy-3-aminopropane459.4SRM, ODC1
11hydrogen45 2410.3CALR, RHO, DHODH, AMD1, NPPB, CYP51A1
12cadaverine45 2410.3SRM, ODC1, AMD1
13acetylcholine45 51 29 24 1113.2CHRM2, NTRK1, RHO, NPPB, NEU1
14dfmo45 29 6111.2SRM, AMD1, ODC1
15guanine45 24 1111.2CHRM2, RHO, CCR5, ADRB1, MYH7
16isoproterenol45 1110.2CHRM2, ODC1, MYH7, ADRB1, NPPB
17epinephrine45 24 1111.2NPPB, ADRB1, GSR, RHO, CANT1
18gsno459.1GSR, CANT1, ODC1
19putrescine45 29 24 1112.1SRM, AMD1, ODC1
20glycerol45 24 1111.1MYH7, RHO, NEU1, DHFR
21spermine29 45 24 1112.0CALR, SRM, AMD1, ODC1
225-methylthioadenosine459.0SRM, ODC1, DHFR
23trypanothione45 119.9SRM, GSR, ODC1
24cocaine45 119.8GSR, CHRM2, ODC1, CCR5
25gtp45 299.8CANT1, CALR, CHRM2, ADRB1, ODC1, RHO
26genistein45 29 61 3 24 1113.8CANT1, GSR, NPPB, ODC1, NTRK1
27cyclophosphamide45 51 1110.8NPPB, TRB, GSR, DHFR
28valine458.7CCR5, ODC1, DHFR, ADRB1, MYH7, RHO
29spermidine45 29 24 1111.6ODC1, AMD1, SRM
30dopamine45 29 24 1111.6ODC1, NPPB, RHO, NTRK1, DHFR, ADRB1
31oxygen45 249.6CYP51A1, NPPB, ADRB1, NTRK1, CALR, CANT1
32heparin45 29 24 1111.5NEU1, NPPB, RHO, CANT1, CALR, CCR5
33nitric oxide45 24 1110.5ODC1, NPPB, CANT1, AMD1, CALR, CHRM2
34histamine45 29 2410.4NPPB, NEU1, CCR5, RHO, CALR, ODC1
35lipid458.4NPPB, RHO, GSR, NTRK1, ADRB1, MYH7
36h2o2458.4CALR, NTRK1, GSR, ODC1, NEU1, DHFR
37threonine458.3MYH7, TRB, RHO, CALR, NTRK1, CHRM2
38lactate458.3NPPB, GSR, CANT1, CALR, NTRK1, DHFR
39glutamine458.1ODC1, MYH7, CALR, CANT1, CCR5, DHFR
40retinoic acid45 249.1NEU1, RHO, NTRK1, CCR5, DHFR, ADRB1
41alanine458.0GSR, RHO, CCR5, DHFR, CHRM2, AMD1
42calcium45 51 24 1111.0CCR5, ADRB1, CALR, NTRK1, NPPB, CANT1
43aspartate457.9RHO, NTRK1, GSR, ODC1, ADRB1, DHODH
44adenylate457.9NTRK1, ADRB1, ODC1, CHRM2, DHFR, GSR
45estrogen457.7NTRK1, NPPB, DHFR, GSR, NEU1, ODC1
46tyrosine457.6CANT1, TRB, NPPB, CALR, NTRK1, CCR5
47glutamate457.6ODC1, MYH7, ADRB1, CCR5, NTRK1, CALR
48arginine457.3NPPB, GSR, MYH7, ADRB1, DHFR, CCR5
49serine457.2AMD1, MYH7, NPPB, RHO, ODC1, NTRK1
50cysteine456.7ODC1, GSR, CANT1, CALR, MYH7, NEU1

GO Terms for genes affiliated with Chagas Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.9RHO, NTRK1, CCR5, CHRM2, ADRB1

Biological processes related to Chagas Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:00719010.0NTRK1, ADRB1
2positive regulation of Ras GTPase activityGO:0323209.9NTRK1, ADRB1
3spermidine biosynthetic processGO:0082959.5SRM, AMD1
4polyamine metabolic processGO:0065959.0SRM, AMD1, ODC1
5cellular nitrogen compound metabolic processGO:0346418.6ODC1, AMD1, SRM
6small molecule metabolic processGO:0442817.5CYP51A1, ODC1, AMD1, NEU1, DHODH, SRM

Products for genes affiliated with Chagas Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chagas Disease

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet