MCID: CHN002
MIFTS: 42

Chancroid malady

Rare diseases, Infectious diseases, Skin diseases, Reproductive diseases categories
Download this MalaCard

Summaries for Chancroid

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards: Chancroid, also known as chancroid & bubo, is related to granuloma inguinale and lymphogranuloma venereum, and has symptoms including painful An important gene associated with Chancroid is HSPD1 (heat shock 60kDa protein 1 (chaperonin)). The drug erythromycin pwdr and the compound gnrh have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.

Wikipedia:65 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Aliases & Classifications for Chancroid

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

chancroid 8 43 10 45
chancroid & bubo 8
ulcus molle, skin 8
ducrey's chancre 8
chancroids 62


External Ids:

Disease Ontology8 DOID:13778
MeSH35 D002602
ICD9CM27 099.0
ICD1025 A57

Related Diseases for Chancroid

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chancroid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1granuloma inguinale10.6
2lymphogranuloma venereum10.6
3syphilis10.4
4gonorrhea10.4
5genital herpes10.2
6blindness10.2
7primary syphilis10.0
8bacterial vaginosis10.0
9herpes simplex10.0
10neutropenia10.0
11connective tissue disease10.0CD36, HSPD1
12malaria10.0HSPD1, CD36
13periodontitis10.0HSPD1, CD36
14periodontal disease9.9HSPD1, CD36

Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Symptoms for Chancroid

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • painful

Drugs & Therapeutics for Chancroid

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Chancroid

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Chancroid

About this section

Anatomical Context for Chancroid

About this section
Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Chancroid:

33
Skin, Lymph node, Testes, Cervix

FMA organs/tissues related to Chancroid:

14
Skin of the genitals

Animal Models for Chancroid or affiliated genes

About this section

Publications for Chancroid

About this section
Sources:
52PubMed
See all sources

Articles related to Chancroid:

(show top 50)    (show all 264)
idTitleAuthorsYear
1
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. (22100216)
2012
2
Chancroid transmission dynamics: a mathematical modeling approach. (21842439)
2011
3
Chancroid and human immunodeficiency virus infection--a review. (18173591)
2008
4
Chancroid. (17151046)
2006
5
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. (16552053)
2006
6
Co-occurrence of chancroid and gonorrhea. (17241572)
2006
7
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
8
Erythema nodosum induced by chancroid. (12407252)
2002
9
Eradicating chancroid. (11584729)
2001
10
Diagnostic tests for chancroid. (10858718)
2000
11
Chancroid: from clinical practice to basic science. (12240879)
2000
12
Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States. (9180178)
1997
13
Alterations in sample preparation increase sensitivity of PCR assay for diagnosis of chancroid. (7790433)
1995
14
In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid. (8363390)
1993
15
Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. (8452188)
1993
16
Treatment of chancroid with a single dose of spectinomycin. (1411847)
1992
17
Chancroid in Dallas: new lessons from an old disease. (1882362)
1991
18
Isolation of anaerobes from bubo associated with chancroid. (1680792)
1991
19
Chancroid: a review for the family practitioner. (1956085)
1991
20
Recent advances in sexually transmitted diseases: reflections on the Center for Disease Control's new sexually transmitted diseases treatment guidelines from the viewpoint of a private practitioner: human immunodeficiency virus (HIV), genital ulcers, chancroid, and syphilis. (2158416)
1990
21
Imported pedal chancroid: case report. (2753511)
1989
22
Chancroid. A newly important sexually transmitted disease. (2802648)
1989
23
Recent developments in sexually transmitted diseases: chancroid--epidemiology, diagnosis, and treatment. (2667898)
1989
24
A comparison of single-dose spectinomycin with five days of trimethoprim-sulfamethoxazole for the treatment of chancroid. (2956702)
1987
25
The diagnosis and treatment of chancroid. (3782534)
1986
26
Single-dose therapy with trimethoprim-sulfametrole for chancroid in females. (3764627)
1986
27
Advances in the diagnosis and management of chancroid. (3532370)
1986
28
Chancroid or chancroidal ulcers. (3979640)
1985
29
Trimethoprim sulphamoxole in the treatment of chancroid. Comparison of two single dose treatment regimens with a five day regimen. (3876325)
1985
30
Treatment of chancroid with enoxacin. (2416179)
1985
31
Chancroid--Massachusetts. (3932837)
1985
32
Chancroidal ulcers that are not chancroid. Cause and epidemiology. (6326691)
1984
33
A clinical variant of chancroid resembling granuloma inguinale. (6639108)
1983
34
Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity. (6601847)
1983
35
Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. (6139629)
1983
36
Chancroid: diagnosis and treatment. (6978893)
1982
37
Bacteriological study of chancroid. (6983497)
1982
38
Chancroid in the male. (13453119)
1957
39
Intramuscular oxytetracycline (terramycin) in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (13363371)
1956
40
VDRL chancroid studies. IV. Experimental chancroid, prophylaxis and treatment. (13292899)
1956
41
Chancroid in Africa. (14862634)
1951
42
Aureomycin in the treatment of chancroid; a report of three cases. (15398709)
1950
43
Studies in the laboratory diagnosis of chancroid disease; preliminary report. (18881809)
1948
44
Streptomycin in experimental chancroid. (20281481)
1947
45
Studies on Chancroid: I. Observations on the Histology with an Evaluation of Biopsy as a Diagnostic Procedure. (19970872)
1946
46
Studies on chancroid; the Ducrey bacillus; growth requirements and inhibition by antibiotic agents. (21013803)
1946
47
Chancroid disease and its treatment. (20993881)
1946
48
Studies on chancroid; observations on the histology with an evaluation of biopsy as a diagnostic procedure. (21018106)
1946
49
Chancroid; granuloma inguinale; clinical and laboratory aspects epidemiology, and treatment. (20292085)
1945
50
TREATMENT OF CHANCROID WITH SULPHANILAMIDE. (20781468)
1938

Variations for Chancroid

About this section

Expression for genes affiliated with Chancroid

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

About this section

Compounds for genes affiliated with Chancroid

About this section
Sources:
45Novoseek
See all sources

Compounds related to Chancroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gnrh459.3CD36, HSPD1

GO Terms for genes affiliated with Chancroid

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Chancroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3CD36, HSPD1
2positive regulation of interleukin-12 productionGO:0327359.2CD36, HSPD1
3positive regulation of interleukin-6 productionGO:0327559.0CD36, HSPD1

Products for genes affiliated with Chancroid

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chancroid

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet