MCID: CHN002
MIFTS: 36

Chancroid malady

Categories: Rare diseases, Infectious diseases, Skin diseases, Reproductive diseases

Aliases & Classifications for Chancroid

About this section

Aliases & Descriptions for Chancroid:

Name: Chancroid 11 48 50 39 13
Ulcus Molle, Skin 11
 
Chancroids 68

Classifications:



External Ids:

Disease Ontology11 DOID:13778
ICD1030 A57
ICD9CM32 099.0
MeSH39 D002602

Summaries for Chancroid

About this section
NIH Rare Diseases:48 Chancroid is a bacterial infection that is spread through sexual contact. It is caused by a type of bacteria called Haemophilus ducreyi. Chancroid is characterized by a small bump on the genital which becomes a painful ulcer. Men may have just one ulcer, but women often develop four or more. About half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. In some cases, the nodes will break through the skin and cause draining abscesses. The swollen lymph nodes and abscesses are often called buboes. Chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. Large lymph node swellings need to be drained, either with a needle or local surgery. Last updated: 12/4/2012

MalaCards based summary: Chancroid, also known as ulcus molle, skin, is related to lymphogranuloma venereum and granuloma inguinale, and has symptoms including painful An important gene associated with Chancroid is CD36 (CD36 Molecule), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drug erythromycin pwdr has been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and testes.

Disease Ontology:11 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.

Wikipedia:71 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Related Diseases for Chancroid

About this section

Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Symptoms & Phenotypes for Chancroid

About this section

Symptoms:

 11
  • painful

Drugs & Therapeutics for Chancroid

About this section

Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AzithromycinapprovedPhase 333383905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
2
Penicillin Gapproved, vet_approvedPhase 32961-33-65904
Synonyms:
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(5R,6R)-Benzylpenicillin
(Phenylmethyl)penicillin
(Phenylmethyl)penicillinic acid
113-98-4 (mono-potassium salt)
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid
4-27-00-05861 (Beilstein Handbook Reference)
46609_FLUKA
46609_RIEDEL
6-(2-Phenylacetamido)penicillanic acid
6-(2-phenylacetamido)penicillanic acid
61-33-6
69-57-8 (mono-hydrochloride salt)
AB00384263
AC-14408
AC1L1LDX
AC1LD0NQ
AC1Q2CBJ
AR-1K9813
Abbocillin
Ayercillin
BPBio1_001206
BRD-K55191674-236-03-7
BRD-K55191674-237-02-7
BRN 0044740
BSPBio_001096
BSPBio_002183
Bencilpenicilina
Bencilpenicilina [Spanish]
Benzopenicillin
Benzyl penicillin
Benzyl-6-aminopenicillinic acid
Benzylpenicillin
Benzylpenicillin (INN)
Benzylpenicillin G
Benzylpenicillin [INN:BAN]
Benzylpenicillin potassium
Benzylpenicillin potassium (JP15)
Benzylpenicillin potassium salt
Benzylpenicilline
Benzylpenicilline [French]
Benzylpenicillinic acid
Benzylpenicillinum
Benzylpenicillinum [Latin]
Bicillin
Bicillin (*Benzathine Salt, Tetrahydrate*)
Bio-0602
C05551
C16H18N2O4S
CHEBI:18208
CHEBI:51354
CHEBI:7963
CHEMBL1223
CHEMBL29
CID443084
CID5904
CID640429
Cillora
Cilloral
Cilopen
Compocillin G
Cosmopen
Crysticillin 300 A.S.
D01053
D02336
DB01053
DivK1c_000316
Dropcillin
EINECS 200-506-3
Free benzylpenicillin
Free penicillin G
Free penicillin II
Galofak
Gelacillin
HMS1920F12
 
HMS2091N12
HMS500P18
HSDB 3166
I06-1083
IDI1_000316
KBio1_000316
KBio2_001413
KBio2_003981
KBio2_006549
KBio3_001683
KBioGR_000942
KBioSS_001413
LS-149836
LS-195224
Liquacillin
MLS000069426
MLS000766897
MLS001032123
MLS001076462
MLS001173382
Megacillin
MolPort-002-511-679
MolPort-003-666-255
NCGC00021679-03
NCGC00021679-04
NCGC00159348-02
NChemBio.2007.21-comp4
NINDS_000316
NSC 193396
P1772
P7794_SIGMA
P8721_SIAL
PCG
PENICILLIN-G
PENK_SIAL
PENK_SIGMA
PG
PNN
Pencillin G
Penicillin
Penicillin G
Penicillin G potassium
Penicillin G potassium (USP)
Penicillin G potassium salt
Penicillin potassium G, crystalline
Penicillin-G potassium
Pfizerpen
Pfizerpen (TN)
Pharmacillin
Phenylacetamidopenicillanic acid
Phenylacetyl-6-aminopenicillanic acid
Pradupen
Prestwick0_001078
Prestwick1_001078
Prestwick2_001078
Prestwick3_001078
SMR000059004
SMR000538912
SPBio_000475
SPBio_002998
SPECTRUM1500465
ST51052951
Sodium benzylpenicillin
Sodium penicillin
Specilline G
Spectrum2_000518
Spectrum3_000542
Spectrum4_000471
Spectrum5_001108
Spectrum_000933
UNII-Q42T66VG0C
Ursopen
ZINC03871701
benzylpenicilline potassique
nchembio.177-comp1
nchembio.252-comp1
penicillin g
potassium 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
3Penicillin G BenzathinePhase 329
4Penicillin G ProcainePhase 329
5Dermatologic AgentsPhase 35674
6Antibiotics, AntitubercularPhase 36972
7Anti-Bacterial AgentsPhase 310884

Interventional clinical trials:

idNameStatusNCT IDPhase
1Male Circumcision for HIV Prevention in Rakai, UgandaCompletedNCT00425984Phase 3
2Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New GuineaActive, not recruitingNCT01955252Phase 3

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: chancroid

Genetic Tests for Chancroid

About this section

Anatomical Context for Chancroid

About this section

MalaCards organs/tissues related to Chancroid:

36
Skin, Testes, Cervix

FMA organs/tissues related to Chancroid:

17
Skin of the genitals

Publications for Chancroid

About this section

Articles related to Chancroid:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
2017 European guideline for the management of chancroid. (28081686)
2017
2
Other sexually transmitted diseases chancroid and donovanosis. (27107782)
2016
3
First case of chancroid in 14 years at the largest STI clinic in Paris, France. (26378189)
2015
4
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
5
Virtual screening of phytochemicals to novel targets in Haemophilus ducreyi towards the treatment of Chancroid. (25258485)
2014
6
Chancroid - desperate patient makes own diagnosis. (24535694)
2014
7
UK National Guideline for the management of chancroid 2014. (25080286)
2014
8
The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid. (24844153)
2014
9
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. (22100216)
2012
10
Etiologic pattern of genital ulcers in Lusaka, Zambia: has chancroid been eliminated? (23001266)
2012
11
Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid. (21646451)
2011
12
Chancroid transmission dynamics: a mathematical modeling approach. (21842439)
2011
13
European guideline for the management of chancroid, 2011. (21571970)
2011
14
Chancroid in an HIV-negative woman in the Midwestern United States. (19926434)
2011
15
A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin. (20191200)
2009
16
Chancroid and human immunodeficiency virus infection--a review. (18173591)
2008
17
Cutaneous chancroid in a visitor from Vanuatu. (18412810)
2008
18
Chancroid. (17151046)
2006
19
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. (16552053)
2006
20
Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. (16581731)
2006
21
Co-occurrence of chancroid and gonorrhea. (17241572)
2006
22
Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid. (16622201)
2006
23
The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid. (15876546)
2005
24
Treatment of chancroid in resource-poor countries. (15918786)
2005
25
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
26
Specificity of antibodies directed against the cytolethal distending toxin of Haemophilus ducreyi in patients with chancroid. (12927521)
2003
27
Chancroid: contemporary appraisal. (12653911)
2003
28
Chancroid: clinical manifestations, diagnosis, and management. (12576620)
2003
29
Erythema nodosum induced by chancroid. (12407252)
2002
30
Chancroid: an update. (17656857)
2002
31
Immunopathogenesis of Haemophilus ducreyi infection (chancroid). (11895928)
2002
32
Eradicating chancroid. (11584729)
2001
33
Diagnostic tests for chancroid. (10858718)
2000
34
Chancroid: from clinical practice to basic science. (12240879)
2000
35
Chancroid in the United Kingdom. (10858704)
2000
36
Thiamphenicol in the treatment of chancroid. A study of 1,128 cases. (10887371)
2000
37
Update on the experimental human model for chancroid infection. (10667906)
2000
38
Immune cells are required for cutaneous ulceration in a swine model of chancroid. (10456960)
1999
39
A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya. (10558945)
1999
40
The use of experimental animal and human models in the study of chancroid pathogenesis. (10215110)
1999
41
Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. (10479178)
1999
42
Treatment of chancroid, 1997. (10028106)
1999
43
National guideline for the management of chancroid. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). (10616383)
1999
44
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. (9884340)
1999
45
Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid. (10496915)
1999
46
Chancroid. (21390754)
1998
47
Comparison of culture media for the laboratory diagnosis of chancroid. (9822303)
1998
48
An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection. (9806035)
1998
49
A comparative study of therapeutic response of patients with clinical chancroid to ciprofloxacin, erythromycin, and cotrimoxazole. (9662762)
1998
50
Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States. (9180178)
1997

Variations for Chancroid

About this section

Expression for genes affiliated with Chancroid

About this section
Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

About this section

Pathways related to Chancroid according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2CD36, CD4
29.2CD36, CD4

GO Terms for genes affiliated with Chancroid

About this section

Cellular components related to Chancroid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.3CD36, CD4, HSPD1
2membrane raftGO:00451218.7CD36, CD4, HSPD1

Biological processes related to Chancroid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MyD88-dependent toll-like receptor signaling pathwayGO:000275510.1CD36, HSPD1
2positive regulation of interleukin-12 productionGO:003273510.1CD36, HSPD1
3positive regulation of interleukin-6 productionGO:003275510.1CD36, HSPD1
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7CD36, CD4
5positive regulation of T cell activationGO:00508709.6CD4, HSPD1
6T cell activationGO:00421109.1CD4, HSPD1

Sources for Chancroid

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet