MCID: CHN002
MIFTS: 43

Chancroid malady

Infectious diseases, Skin diseases categories

Summaries for Chancroid

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards: Chancroid, also known as chancroid & bubo, is related to granuloma inguinale and lymphogranuloma venereum, and has symptoms including painful An important gene associated with Chancroid is B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6). The drug erythromycin pwdr and the compounds pyruvate and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.

Wikipedia:63 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Aliases & Classifications for Chancroid

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

chancroid 8 42 10 44
chancroid & bubo 8
ulcus molle, skin 8
ducrey's chancre 8
chancroids 60


External Ids:

Disease Ontology8 DOID:13778
ICD9CM27 099.0
MeSH34 D002602
ICD1025 A57

Related Diseases for Chancroid

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17GeneCards, 18GeneDecks
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Diseases related to Chancroid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1granuloma inguinale10.6
2lymphogranuloma venereum10.6
3syphilis10.4
4gonorrhea10.3
5genital herpes10.1
6down syndrome10.0PRDX6
7myeloma10.0CD36
8pancytopenia10.0GBA
9cataract10.0HSPD1
10cervicitis10.0HSPD1
11adenocarcinoma10.0WT1, PRDX6
12trachoma10.0WARS, HSPD1
13periodontitis10.0HSPD1, CD36
14bacterial vaginosis10.0
15primary syphilis10.0
16herpes simplex10.0
17neutropenia10.0
18malaria10.0CD36, WARS, HSPD1
19connective tissue disease10.0CD36, HSPD1

Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Clinical Features for Chancroid

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8Disease Ontology
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Symptoms:

8
  • painful

Drugs & Therapeutics for Chancroid

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chancroid

Drug clinical trials:

Search ClinicalTrials for Chancroid

Search NIH Clinical Center for Chancroid

Search CenterWatch for Chancroid

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Chancroid

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Anatomical Context for Chancroid

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Chancroid:

32
Skin, Lymph node, Testes, Cervix

FMA organs/tissues related to Chancroid:

14
Skin of the genitals

Animal Models for Chancroid or affiliated genes

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Publications for Chancroid

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50PubMed
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Articles related to Chancroid:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Etiologic pattern of genital ulcers in Lusaka, Zambia: has chancroid been eliminated? (23001266)
2012
2
Cutaneous chancroid in a visitor from Vanuatu. (18412810)
2008
3
Immunopathogenesis of Haemophilus ducreyi infection (chancroid). (11895928)
2002
4
Eradicating chancroid. (11584729)
2001
5
Diagnostic tests for chancroid. (10858718)
2000
6
Immune cells are required for cutaneous ulceration in a swine model of chancroid. (10456960)
1999
7
Chancroid. (8743258)
1996
8
Alterations in sample preparation increase sensitivity of PCR assay for diagnosis of chancroid. (7790433)
1995
9
Chancroid epidemiology in New Orleans men. (7622888)
1995
10
In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid. (8363390)
1993
11
Chancroid: a review for the family practitioner. (1956085)
1991
12
Intravenous single-dose ceftriaxone treatment of chancroid. (1743374)
1991
13
Treatment of chancroid, 1989. (2201074)
1990
14
Sulphaphenazole, streptomycin and sulphaphenazole combination, trimethoprim, and erythromycin in the treatment of chancroid. (2187791)
1990
15
Chancroid: results from an outbreak in Houston, Texas. (2251526)
1990
16
Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. (2502065)
1989
17
Incidence of chancroid in Vienna from 1980 to 1988. (2788626)
1989
18
Treating chancroid with enoxacin. (3044978)
1988
19
Chancroid in El Salvador. Increasing incidence, clinical features, and therapeutics. (3391712)
1988
20
Chancroid in the United States. Reestablishment of an old disease. (2824868)
1987
21
Ceftriaxone in the treatment of chancroid. (3509497)
1987
22
Single-dose ceftriaxone for chancroid. (3566241)
1987
23
Three day oral course of Augmentin to treat chancroid. (3733082)
1986
24
Laboratory diagnosis of chancroid in Nairobi, Kenya. (3533507)
1986
25
Short-course treatment of chancroid with co-trimoxazole (Septrin) (3890302)
1985
26
Treatment of chancroid. (6600752)
1983
27
Single-dose therapy of chancroid with trimethoprim-sulfametrole. (6343878)
1983
28
Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole. (6351957)
1983
29
Drug of choice for chancroid. (6129437)
1983
30
Isolation of Haemophilus ducreyi from a chancroid in Papua New Guinea. (6336300)
1983
31
Antimicrobial therapy of chancroid: effectiveness of erythromycin. (6355314)
1983
32
Chancroid: diagnosis and treatment. (6978893)
1982
33
Bacteriological study of chancroid. (6983497)
1982
34
Chancroid--California. (6804777)
1982
35
Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America. (6971469)
1980
36
Chancroid. (517383)
1979
37
A case of chancroid. (887039)
1977
38
Chancroid. (4635617)
1972
39
Treatment of chancroid. A comparison of tetracycline and sulfisoxazole. (5350417)
1969
40
Chemotherapy in chancroid. (13012365)
1952
41
Specificity of skin tests in lymphogranuloma venereum and chancroid. (14837647)
1951
42
Aureomycin and chloramphenicol in chancroid. (14821463)
1951
43
The use of streptomycin in the treatment of chancroid. (14796055)
1950
44
Oral aureomycin therapy for chancroid; report of case. (18128819)
1949
45
Streptomycin therapy in a case of sulfonamide-resistant Hemophilus ducreyi (chancroid) infection. (18129457)
1949
46
Evaluation of the Ducrey skin test for chancroid. (20281488)
1947
47
Chancroid disease and its treatment. (20993881)
1946
48
Chancroid of the uterine cervix. (20992954)
1946
49
Chancroid; granuloma inguinale; clinical and laboratory aspects epidemiology, and treatment. (20292085)
1945
50
Granuloma Inguinale, Complicated with Syphiloma of Vulva and Chancroidal Infection : Report of a Case. (20892899)
1939

Genetic Variations for Chancroid

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Expression for genes affiliated with Chancroid

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

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Compounds for genes affiliated with Chancroid

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44Novoseek
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Compounds related to Chancroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pyruvate449.3PRDX6, GBA, HSPD1
2polysaccharide449.1HSPD1, GBA, CMAS
3vegf448.7CD36, WT1, HGS, HSPD1
4cysteine448.7CD36, HSPD1, WT1, PRDX6, GBA
5serine448.1GBA, CD36, PRDX6, WARS, WT1

GO Terms for genes affiliated with Chancroid

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16Gene Ontology
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Biological processes related to Chancroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:0327559.8CD36, HSPD1
2positive regulation of interleukin-12 productionGO:0327359.5CD36, HSPD1

Products for genes affiliated with Chancroid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chancroid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet