MCID: CHN002
MIFTS: 40

Chancroid malady

Infectious, Skin categories

Summaries for Chancroid

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards: Chancroid, also known as chancroid & bubo, is related to granuloma inguinale and lymphogranuloma venereum, and has symptoms including painful An important gene associated with Chancroid is B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6). The drug erythromycin pwdr and the compounds pyruvate and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, lymph node and skin.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.

Wikipedia:64 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Aliases & Classifications for Chancroid

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Skin


Aliases & Descriptions:

chancroid 8 43 10 45
chancroid & bubo 8
ulcus molle, skin 8
ducrey's chancre 8
chancroids 61


External Ids:

Disease Ontology8 DOID:13778
ICD9CM27 099.0
MeSH35 D002602
ICD1025 A57

Related Diseases for Chancroid

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chancroid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1granuloma inguinale10.6
2lymphogranuloma venereum10.6
3syphilis10.4
4gonorrhea10.3
5genital herpes10.1
6bacterial vaginosis10.0
7primary syphilis10.0
8lip disease10.0
9down syndrome10.0PRDX6
10myeloma10.0CD36
11pancytopenia10.0GBA
12cataract10.0HSPD1
13cervicitis10.0HSPD1
14adenocarcinoma10.0WT1, PRDX6
15trachoma10.0WARS, HSPD1
16periodontitis10.0HSPD1, CD36
17malaria10.0CD36, WARS, HSPD1
18connective tissue disease10.0CD36, HSPD1

Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Clinical Features for Chancroid

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • painful

Drugs & Therapeutics for Chancroid

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chancroid

Drug clinical trials:

Search ClinicalTrials for Chancroid

Search NIH Clinical Center for Chancroid

Search CenterWatch for Chancroid

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Chancroid

Anatomical Context for Chancroid

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Chancroid:

33
Lymph node, Skin, Cervix

FMA organs/tissues related to Chancroid:

14
Skin of the genitals

Animal Models for Chancroid or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Chancroid

Sources:
51PubMed
See all sources

Articles related to Chancroid:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid. (21646451)
2011
2
Chancroid in an HIV-negative woman in the Midwestern United States. (19926434)
2011
3
Chancroid. (17151046)
2006
4
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. (16552053)
2006
5
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
6
Chancroid: an update. (17656857)
2002
7
Update on the experimental human model for chancroid infection. (10667906)
2000
8
National guideline for the management of chancroid. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). (10616383)
1999
9
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. (9884340)
1999
10
A comparative study of therapeutic response of patients with clinical chancroid to ciprofloxacin, erythromycin, and cotrimoxazole. (9662762)
1998
11
Update on chancroid: an important cause of genital ulcer disease. (11361592)
1996
12
Laboratory diagnosis of chancroid using species-specific primers from Haemophilus ducreyi groEL and the polymerase chain reaction. (8849652)
1995
13
Comparison of azithromycin and ceftriaxone for the treatment of chancroid. (8562752)
1995
14
Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. (7974076)
1994
15
Laboratory techniques used in the diagnosis of chancroid, granuloma inguinale, and lymphogranuloma venereum. (8143374)
1994
16
Laboratory techniques in the investigation of chancroid, lymphogranuloma venereum and donovanosis. (1582657)
1992
17
Chancroid in Dallas: new lessons from an old disease. (1882362)
1991
18
Chancroid. (2181505)
1990
19
Persistent genital ulceration. Chancroid. (2467625)
1989
20
Winnipeg suffered second chancroid outbreak, team reports. (2909280)
1989
21
Chancroid and HIV. (2493913)
1989
22
Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid. (3293526)
1988
23
Efficacy and safety of a single dose therapy of a 500 mg ciprofloxacin tablet in chancroid patients. (3286513)
1988
24
Chancroid or chancroidal ulcers. (3979640)
1985
25
Chancroid and Haemophilus ducreyi. (3872617)
1985
26
A mixed infection of syphilis and chancroid. (6707258)
1984
27
A clinical variant of chancroid resembling granuloma inguinale. (6639108)
1983
28
Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. (6139629)
1983
29
Chancroid and granuloma inguinale. (6687703)
1983
30
Short-course and single-dose antimicrobial therapy for chancroid in Kenya: studies with rifampin alone and in combination with trimethoprim. (6635447)
1983
31
Treatment of chancroid by clavulanic acid with amoxycillin in patients with beta-lactamase-positive Haemophilus ducreyi infection. (6125676)
1982
32
Single-dose thiamphenicol for chancroid. (6128536)
1982
33
Epidemic of chancroid in Greenland 1977-78. (85881)
1979
34
Ultrastructural detection of Haemophilus ducreyi in biopsies of chancroid. (310659)
1978
35
Simplified laboratory technique for diagnosis of chancroid. (4914265)
1970
36
Intramuscular oxytetracycline (terramycin) in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (13363371)
1956
37
VDRL chancroid studies. IV. Experimental chancroid, prophylaxis and treatment. (13292899)
1956
38
V.D.R.L. chancroid studies. II. Experimental chancroid in the rabbit. (13332286)
1956
39
V.D.R.L. chancroid studies. III. Use of Ducrey skin test vaccines on rabbits. (13332287)
1956
40
Chancroid; a report of 1,402 cases. (14952691)
1952
41
Experimental chancroid in man; relative effectiveness of various drugs tested by three methods. (14911434)
1952
42
Chancroid in tropical Africa: Southern Rhodesia and the Gold Coast. (14859082)
1951
43
Terramycin in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (14878094)
1951
44
Chancroid in women in Manila. (20240336)
1947
45
Penicillin in chancroid ulcers of pudenda. (20992831)
1946
46
Studies on chancroid; Ducrey skin reactions in Negro hospital patients. (21024752)
1946
47
Chancroid? (21065260)
1946
48
The significance of immunologic tests in lymphogranuloma venereum and chancroid. (20275632)
1945
49
Studies on chancroid; efficiency of the cultural method of diagnosis. (21005458)
1945
50
Observations on the Distribution and Culture of the Chancroid Bacillus. (19971543)
1903

Genetic Variations for Chancroid

Expression for genes affiliated with Chancroid

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

Compounds for genes affiliated with Chancroid

Sources:
45Novoseek
See all sources

Compounds related to Chancroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pyruvate459.3PRDX6, GBA, HSPD1
2polysaccharide459.1HSPD1, GBA, CMAS
3vegf458.7CD36, WT1, HGS, HSPD1
4cysteine458.7CD36, HSPD1, WT1, PRDX6, GBA
5serine458.1GBA, CD36, PRDX6, WARS, WT1

GO Terms for genes affiliated with Chancroid

Sources:
16Gene Ontology
See all sources

Biological processes related to Chancroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:0327559.8CD36, HSPD1
2positive regulation of interleukin-12 productionGO:0327359.5CD36, HSPD1

Products for genes affiliated with Chancroid

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chancroid

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet