MCID: CHN002
MIFTS: 43

Chancroid malady

Infectious diseases, Skin diseases categories

Summaries for Chancroid

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards: Chancroid, also known as chancroid & bubo, is related to granuloma inguinale and lymphogranuloma venereum, and has symptoms including painful An important gene associated with Chancroid is B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6). The drug erythromycin pwdr and the compounds pyruvate and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.

Wikipedia:63 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Aliases & Classifications for Chancroid

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

chancroid 8 42 10 44
chancroid & bubo 8
ulcus molle, skin 8
ducrey's chancre 8
chancroids 60


External Ids:

Disease Ontology8 DOID:13778
ICD9CM27 099.0
MeSH34 D002602
ICD1025 A57

Related Diseases for Chancroid

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17GeneCards, 18GeneDecks
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Diseases related to Chancroid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1granuloma inguinale10.6
2lymphogranuloma venereum10.6
3syphilis10.4
4gonorrhea10.3
5genital herpes10.1
6down syndrome10.0PRDX6
7myeloma10.0CD36
8pancytopenia10.0GBA
9cataract10.0HSPD1
10cervicitis10.0HSPD1
11adenocarcinoma10.0WT1, PRDX6
12trachoma10.0WARS, HSPD1
13periodontitis10.0HSPD1, CD36
14bacterial vaginosis10.0
15primary syphilis10.0
16herpes simplex10.0
17neutropenia10.0
18malaria10.0CD36, WARS, HSPD1
19connective tissue disease10.0CD36, HSPD1

Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Clinical Features for Chancroid

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8Disease Ontology
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Symptoms:

8
  • painful

Drugs & Therapeutics for Chancroid

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chancroid

Drug clinical trials:

Search ClinicalTrials for Chancroid

Search NIH Clinical Center for Chancroid

Search CenterWatch for Chancroid

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Chancroid

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Anatomical Context for Chancroid

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Chancroid:

32
Skin, Lymph node, Testes, Cervix

FMA organs/tissues related to Chancroid:

14
Skin of the genitals

Animal Models for Chancroid or affiliated genes

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Publications for Chancroid

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50PubMed
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Articles related to Chancroid:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. (22100216)
2012
2
Co-occurrence of chancroid and gonorrhea. (17241572)
2006
3
Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. (16581731)
2006
4
The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid. (15876546)
2005
5
Thiamphenicol in the treatment of chancroid. A study of 1,128 cases. (10887371)
2000
6
Chancroid in the United Kingdom. (10858704)
2000
7
Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid. (10496915)
1999
8
Comparison of culture media for the laboratory diagnosis of chancroid. (9822303)
1998
9
Evaluation of humoral and cell-mediated inducible immunity to Haemophilus ducreyi in an animal model of chancroid. (8613391)
1996
10
A morphological study of penile chancroid lesions in human immunodeficiency virus (HIV)-positive and -negative African men with a hypothesis concerning the role of chancroid in HIV transmission. (8892592)
1996
11
Single dose trimethoprim-sulphamethoxazole for treatment of chancroid. (7744411)
1995
12
Chancroid detected by polymerase chain reaction--Jackson, Mississippi, 1994-1995. (8578414)
1995
13
Induction of protective immunity to Haemophilus ducreyi in the temperature-dependent rabbit model of experimental chancroid. (8254191)
1994
14
Mechanisms of skin adherence, penetration and tissue necrosis production by Haemophilus ducreyi, the causative agent of chancroid. (1636361)
1992
15
Pathophysiological concept of Haemophilus ducreyi infection (chancroid) (1391058)
1992
16
Chancroid in the United States, 1981-1990: evidence for underreporting of cases. (1635549)
1992
17
Cultural diagnosis of chancroid. (1845282)
1991
18
Isolation of anaerobes from clinical chancroid associated with fluctuant bubo in men. (1959953)
1991
19
Recent advances in sexually transmitted diseases: reflections on the Center for Disease Control's new sexually transmitted diseases treatment guidelines from the viewpoint of a private practitioner: human immunodeficiency virus (HIV), genital ulcers, chancroid, and syphilis. (2158416)
1990
20
Chancroid. A newly important sexually transmitted disease. (2802648)
1989
21
Chancroid and Haemophilus ducreyi. (2650859)
1989
22
Treating chancroid: summary of studies in southern Africa. (2629710)
1989
23
Lymphogranuloma venereum, chancroid, and granuloma inguinale. (2687744)
1989
24
Chancroid. (2493294)
1989
25
Chancroid in Liverpool. (3346032)
1988
26
In vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid. (3141171)
1988
27
Single-dose therapy with trimethoprim-sulfametrole for chancroid in females. (3764627)
1986
28
Clinical evaluation of rosoxacin for the treatment of chancroid. (3489439)
1986
29
Use of dot-immunobinding and immunofluorescence assays to investigate clinically suspected cases of chancroid. (3517183)
1986
30
Leads from the MMWR. Chancroid--Massachusetts. (3485202)
1986
31
Chancroid. Recent advances in treatment and control. (3485081)
1986
32
Treatment of chancroid with enoxacin. (2416179)
1985
33
Chancroid--Massachusetts. (3932837)
1985
34
An outbreak of chancroid in Orange County, California: descriptive epidemiology and disease-control measures. (2985711)
1985
35
Thiamphenicol in the treatment of chancroid in men. (6335300)
1984
36
Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity. (6601847)
1983
37
Isolation of Haemophilus ducreyi from patients with chancroid in Auckland. (7050782)
1982
38
Treatment of chancroid with erythromycin. (6974899)
1981
39
Treatment of chancroid. Comparison of sulfamethoxazole-trimethoprim with recommended therapies. (7024580)
1981
40
The treatment of chancroid: comparison of one week of sulfisoxazole with single dose doxycycline. (479062)
1979
41
The management of resistant chancroid in Vietnam. (4537134)
1972
42
The treatment of chancroid. (14000783)
1963
43
Chancroid in the male. (13453119)
1957
44
Role of the hyperimmune reaction in chancroid; effect of ACTH. (13312156)
1956
45
The treatment of granuloma inguinale, lymphogranuloma venereum, chancroid, and gonorrhea. (14867823)
1951
46
Studies on Chancroid: I. Observations on the Histology with an Evaluation of Biopsy as a Diagnostic Procedure. (19970872)
1946
47
The clinical and laboratory differentiation between chancroid and lymphogranuloma venereum. (20984465)
1946
48
Observations on chancroid therapy with and without sulfathiazole. (21016708)
1946
49
Observations on chancroid therapy with and without sulfathiazole. (20992352)
1946
50
TREATMENT OF CHANCROID WITH SULPHANILAMIDE. (20781468)
1938

Genetic Variations for Chancroid

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Expression for genes affiliated with Chancroid

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chancroid

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Pathways for genes affiliated with Chancroid

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Compounds for genes affiliated with Chancroid

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44Novoseek
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Compounds related to Chancroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pyruvate449.3HSPD1, PRDX6, GBA
2polysaccharide449.1CMAS, GBA, HSPD1
3vegf448.7HSPD1, HGS, WT1, CD36
4cysteine448.7GBA, CD36, PRDX6, WT1, HSPD1
5serine448.1WARS, PRDX6, CD36, GBA, WT1

GO Terms for genes affiliated with Chancroid

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16Gene Ontology
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Biological processes related to Chancroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:0327559.8CD36, HSPD1
2positive regulation of interleukin-12 productionGO:0327359.5CD36, HSPD1

Products for genes affiliated with Chancroid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chancroid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet