MCID: CHN002
MIFTS: 38

Chancroid malady

Rare diseases, Infectious diseases, Skin diseases, Reproductive diseases categories

Aliases & Classifications for Chancroid

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Aliases & Descriptions for Chancroid:

Name: Chancroid 10 45 47 12 36
Ulcus Molle, Skin 10
Chancroid Bubo 10
 
Ducrey's Chancre 10
Chancroids 65


Classifications:



External Ids:

Disease Ontology10 DOID:13778
ICD9CM29 099.0
MeSH36 D002602
ICD1027 A57

Summaries for Chancroid

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NIH Rare Diseases:45 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards based summary: Chancroid, also known as ulcus molle, skin, is related to lymphogranuloma venereum and granuloma inguinale, and has symptoms including painful An important gene associated with Chancroid is CD36 (CD36 Molecule (Thrombospondin Receptor)), and among its related pathways is Hematopoietic cell lineage. The drug erythromycin pwdr has been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node.

Disease Ontology:10 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.

Wikipedia:68 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Related Diseases for Chancroid

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Graphical network of diseases related to Chancroid:



Diseases related to chancroid

Symptoms for Chancroid

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Symptoms:

 10
  • painful

Drugs & Therapeutics for Chancroid

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Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AzithromycinapprovedPhase 330983905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
2
Penicillin GapprovedPhase 32561-33-65904
Synonyms:
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(5R,6R)-Benzylpenicillin
(Phenylmethyl)penicillin
(Phenylmethyl)penicillinic acid
113-98-4 (mono-potassium salt)
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid
4-27-00-05861 (Beilstein Handbook Reference)
46609_FLUKA
46609_RIEDEL
6-(2-Phenylacetamido)penicillanic acid
6-(2-phenylacetamido)penicillanic acid
61-33-6
69-57-8 (mono-hydrochloride salt)
AB00384263
AC-14408
AC1L1LDX
AC1LD0NQ
AC1Q2CBJ
AR-1K9813
Abbocillin
Ayercillin
BPBio1_001206
BRD-K55191674-236-03-7
BRD-K55191674-237-02-7
BRN 0044740
BSPBio_001096
BSPBio_002183
Bencilpenicilina
Bencilpenicilina [Spanish]
Benzopenicillin
Benzyl penicillin
Benzyl-6-aminopenicillinic acid
Benzylpenicillin
Benzylpenicillin (INN)
Benzylpenicillin G
Benzylpenicillin [INN:BAN]
Benzylpenicillin potassium
Benzylpenicillin potassium (JP15)
Benzylpenicillin potassium salt
Benzylpenicillin sodium
Benzylpenicilline
Benzylpenicilline [French]
Benzylpenicillinic acid
Benzylpenicillinum
Benzylpenicillinum [Latin]
Bicillin
Bicillin (*Benzathine Salt, Tetrahydrate*)
Bio-0602
C05551
C16H18N2O4S
CHEBI:18208
CHEBI:51354
CHEBI:7963
CHEMBL1223
CHEMBL29
CID443084
CID5904
CID640429
Cillora
Cilloral
Cilopen
Compocillin G
Cosmopen
Crysticillin 300 A.S.
D01053
D02336
DB01053
DivK1c_000316
Dropcillin
EINECS 200-506-3
Free benzylpenicillin
Free penicillin G
Free penicillin II
Free penicillin ii
Galofak
Gelacillin
HMS1920F12
 
HMS2091N12
HMS500P18
HSDB 3166
I06-1083
IDI1_000316
KBio1_000316
KBio2_001413
KBio2_003981
KBio2_006549
KBio3_001683
KBioGR_000942
KBioSS_001413
LS-149836
LS-195224
Liquacillin
MLS000069426
MLS000766897
MLS001032123
MLS001076462
MLS001173382
Megacillin
MolPort-002-511-679
MolPort-003-666-255
NCGC00021679-03
NCGC00021679-04
NCGC00159348-02
NChemBio.2007.21-comp4
NINDS_000316
NSC 193396
P1772
P7794_SIGMA
P8721_SIAL
PCG
PENICILLIN-G
PENK_SIAL
PENK_SIGMA
PG
PNN
Pencillin G
Penicillin
Penicillin G
Penicillin G Potassium
Penicillin G potassium
Penicillin G potassium (USP)
Penicillin G potassium salt
Penicillin potassium G, crystalline
Penicillin-G potassium
Pfizerpen
Pfizerpen (TN)
Pharmacillin
Phenylacetamidopenicillanic acid
Phenylacetyl-6-aminopenicillanic acid
Pradupen
Prestwick0_001078
Prestwick1_001078
Prestwick2_001078
Prestwick3_001078
SMR000059004
SMR000538912
SPBio_000475
SPBio_002998
SPECTRUM1500465
ST51052951
Sodium benzylpenicillin
Sodium penicillin
Specilline G
Spectrum2_000518
Spectrum3_000542
Spectrum4_000471
Spectrum5_001108
Spectrum_000933
UNII-Q42T66VG0C
Ursopen
ZINC03871701
benzylpenicilline potassique
nchembio.177-comp1
nchembio.252-comp1
penicillin g
potassium 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
3Penicillin G ProcainePhase 325
4Penicillin G BenzathinePhase 325

Interventional clinical trials:

idNameStatusNCT IDPhase
1Male Circumcision for HIV Prevention in Rakai, UgandaCompletedNCT00425984Phase 3
2Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New GuineaActive, not recruitingNCT01955252Phase 3

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Chancroid

Genetic Tests for Chancroid

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Anatomical Context for Chancroid

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MalaCards organs/tissues related to Chancroid:

33
Skin, Lymph node, Testes, Cervix

FMA organs/tissues related to Chancroid:

16
Skin of the genitals

Animal Models for Chancroid or affiliated genes

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Publications for Chancroid

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Articles related to Chancroid:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
2
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. (22100216)
2012
3
Chancroid transmission dynamics: a mathematical modeling approach. (21842439)
2011
4
Chancroid and human immunodeficiency virus infection--a review. (18173591)
2008
5
Chancroid. (17151046)
2006
6
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. (16552053)
2006
7
Co-occurrence of chancroid and gonorrhea. (17241572)
2006
8
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
9
Eradicating chancroid. (11584729)
2001
10
Diagnostic tests for chancroid. (10858718)
2000
11
Chancroid: from clinical practice to basic science. (12240879)
2000
12
Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States. (9180178)
1997
13
Alterations in sample preparation increase sensitivity of PCR assay for diagnosis of chancroid. (7790433)
1995
14
In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid. (8363390)
1993
15
Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. (8452188)
1993
16
Treatment of chancroid with a single dose of spectinomycin. (1411847)
1992
17
Chancroid in Dallas: new lessons from an old disease. (1882362)
1991
18
Isolation of anaerobes from bubo associated with chancroid. (1680792)
1991
19
Chancroid: a review for the family practitioner. (1956085)
1991
20
Recent advances in sexually transmitted diseases: reflections on the Center for Disease Control's new sexually transmitted diseases treatment guidelines from the viewpoint of a private practitioner: human immunodeficiency virus (HIV), genital ulcers, chancroid, and syphilis. (2158416)
1990
21
Imported pedal chancroid: case report. (2753511)
1989
22
Chancroid. A newly important sexually transmitted disease. (2802648)
1989
23
Recent developments in sexually transmitted diseases: chancroid--epidemiology, diagnosis, and treatment. (2667898)
1989
24
A comparison of single-dose spectinomycin with five days of trimethoprim-sulfamethoxazole for the treatment of chancroid. (2956702)
1987
25
The diagnosis and treatment of chancroid. (3782534)
1986
26
Single-dose therapy with trimethoprim-sulfametrole for chancroid in females. (3764627)
1986
27
Advances in the diagnosis and management of chancroid. (3532370)
1986
28
Chancroid or chancroidal ulcers. (3979640)
1985
29
Trimethoprim sulphamoxole in the treatment of chancroid. Comparison of two single dose treatment regimens with a five day regimen. (3876325)
1985
30
Treatment of chancroid with enoxacin. (2416179)
1985
31
Chancroid--Massachusetts. (3932837)
1985
32
Chancroidal ulcers that are not chancroid. Cause and epidemiology. (6326691)
1984
33
A clinical variant of chancroid resembling granuloma inguinale. (6639108)
1983
34
Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity. (6601847)
1983
35
Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. (6139629)
1983
36
Chancroid: diagnosis and treatment. (6978893)
1982
37
Bacteriological study of chancroid. (6983497)
1982
38
Chancroid in the male. (13453119)
1957
39
Intramuscular oxytetracycline (terramycin) in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (13363371)
1956
40
VDRL chancroid studies. IV. Experimental chancroid, prophylaxis and treatment. (13292899)
1956
41
Chancroid in Africa. (14862634)
1951
42
Aureomycin in the treatment of chancroid; a report of three cases. (15398709)
1950
43
Studies in the laboratory diagnosis of chancroid disease; preliminary report. (18881809)
1948
44
Streptomycin in experimental chancroid. (20281481)
1947
45
Studies on Chancroid: I. Observations on the Histology with an Evaluation of Biopsy as a Diagnostic Procedure. (19970872)
1946
46
Studies on chancroid; the Ducrey bacillus; growth requirements and inhibition by antibiotic agents. (21013803)
1946
47
Chancroid disease and its treatment. (20993881)
1946
48
Studies on chancroid; observations on the histology with an evaluation of biopsy as a diagnostic procedure. (21018106)
1946
49
Chancroid; granuloma inguinale; clinical and laboratory aspects epidemiology, and treatment. (20292085)
1945
50
TREATMENT OF CHANCROID WITH SULPHANILAMIDE. (20781468)
1938

Variations for Chancroid

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Expression for genes affiliated with Chancroid

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Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

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Pathways related to Chancroid according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD36, CD4

GO Terms for genes affiliated with Chancroid

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Cellular components related to Chancroid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.1CD36, CD4, HSPD1
2cell surfaceGO:00099868.8CD36, CD4, HSPD1

Biological processes related to Chancroid according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.0CD36, HSPD1
2positive regulation of T cell activationGO:00508709.8CD4, HSPD1
3positive regulation of interleukin-6 productionGO:00327559.7CD36, HSPD1
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7CD36, CD4
5MyD88-dependent toll-like receptor signaling pathwayGO:00027559.6CD36, HSPD1
6T cell activationGO:00421109.5CD4, HSPD1
7viral processGO:00160328.9CD4, HSPD1, RPL31

Sources for Chancroid

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet