MCID: CHN002
MIFTS: 39

Chancroid malady

Categories: Rare diseases, Infectious diseases, Skin diseases, Reproductive diseases

Aliases & Classifications for Chancroid

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Aliases & Descriptions for Chancroid:

Name: Chancroid 10 45 47 12 36
Ulcus Molle, Skin 10
 
Chancroids 65

Classifications:



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Disease Ontology10 DOID:13778
ICD1027 A57
ICD9CM29 099.0
MeSH36 D002602
UMLS65 C0007947

Summaries for Chancroid

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NIH Rare Diseases:45 Chancroid is a bacterial infection that is spread through sexual contact. it is caused by a type of bacteria called haemophilus ducreyi. chancroid is characterized by a small bump on the genital which becomes a painful ulcer. men may have just one ulcer, but women often develop four or more. about half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. in some cases, the nodes will break through the skin and cause draining abscesses. the swollen lymph nodes and abscesses are often called buboes. chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. large lymph node swellings need to be drained, either with a needle or local surgery. last updated: 12/4/2012

MalaCards based summary: Chancroid, also known as ulcus molle, skin, is related to amyloidosis and lymphoma, and has symptoms including painful An important gene associated with Chancroid is CD36 (CD36 Molecule), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drug erythromycin pwdr has been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node, and related mouse phenotype endocrine/exocrine gland.

Disease Ontology:10 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.

Wikipedia:68 Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection... more...

Related Diseases for Chancroid

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Graphical network of the top 20 diseases related to Chancroid:



Diseases related to chancroid

Symptoms for Chancroid

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Symptoms:

 10
  • painful

Drugs & Therapeutics for Chancroid

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Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AzithromycinapprovedPhase 332283905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
2
Penicillin GapprovedPhase 32661-33-65904
Synonyms:
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(5R,6R)-Benzylpenicillin
(Phenylmethyl)penicillin
(Phenylmethyl)penicillinic acid
113-98-4 (mono-potassium salt)
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid
4-27-00-05861 (Beilstein Handbook Reference)
46609_FLUKA
46609_RIEDEL
6-(2-Phenylacetamido)penicillanic acid
6-(2-phenylacetamido)penicillanic acid
61-33-6
69-57-8 (mono-hydrochloride salt)
AB00384263
AC-14408
AC1L1LDX
AC1LD0NQ
AC1Q2CBJ
AR-1K9813
Abbocillin
Ayercillin
BPBio1_001206
BRD-K55191674-236-03-7
BRD-K55191674-237-02-7
BRN 0044740
BSPBio_001096
BSPBio_002183
Bencilpenicilina
Bencilpenicilina [Spanish]
Benzopenicillin
Benzyl penicillin
Benzyl-6-aminopenicillinic acid
Benzylpenicillin
Benzylpenicillin (INN)
Benzylpenicillin G
Benzylpenicillin [INN:BAN]
Benzylpenicillin potassium
Benzylpenicillin potassium (JP15)
Benzylpenicillin potassium salt
Benzylpenicillin sodium
Benzylpenicilline
Benzylpenicilline [French]
Benzylpenicillinic acid
Benzylpenicillinum
Benzylpenicillinum [Latin]
Bicillin
Bicillin (*Benzathine Salt, Tetrahydrate*)
Bio-0602
C05551
C16H18N2O4S
CHEBI:18208
CHEBI:51354
CHEBI:7963
CHEMBL1223
CHEMBL29
CID443084
CID5904
CID640429
Cillora
Cilloral
Cilopen
Compocillin G
Cosmopen
Crysticillin 300 A.S.
D01053
D02336
DB01053
DivK1c_000316
Dropcillin
EINECS 200-506-3
Free benzylpenicillin
Free penicillin G
Free penicillin II
Free penicillin ii
Galofak
Gelacillin
HMS1920F12
 
HMS2091N12
HMS500P18
HSDB 3166
I06-1083
IDI1_000316
KBio1_000316
KBio2_001413
KBio2_003981
KBio2_006549
KBio3_001683
KBioGR_000942
KBioSS_001413
LS-149836
LS-195224
Liquacillin
MLS000069426
MLS000766897
MLS001032123
MLS001076462
MLS001173382
Megacillin
MolPort-002-511-679
MolPort-003-666-255
NCGC00021679-03
NCGC00021679-04
NCGC00159348-02
NChemBio.2007.21-comp4
NINDS_000316
NSC 193396
P1772
P7794_SIGMA
P8721_SIAL
PCG
PENICILLIN-G
PENK_SIAL
PENK_SIGMA
PG
PNN
Pencillin G
Penicillin
Penicillin G
Penicillin G Potassium
Penicillin G potassium
Penicillin G potassium (USP)
Penicillin G potassium salt
Penicillin potassium G, crystalline
Penicillin-G potassium
Pfizerpen
Pfizerpen (TN)
Pharmacillin
Phenylacetamidopenicillanic acid
Phenylacetyl-6-aminopenicillanic acid
Pradupen
Prestwick0_001078
Prestwick1_001078
Prestwick2_001078
Prestwick3_001078
SMR000059004
SMR000538912
SPBio_000475
SPBio_002998
SPECTRUM1500465
ST51052951
Sodium benzylpenicillin
Sodium penicillin
Specilline G
Spectrum2_000518
Spectrum3_000542
Spectrum4_000471
Spectrum5_001108
Spectrum_000933
UNII-Q42T66VG0C
Ursopen
ZINC03871701
benzylpenicilline potassique
nchembio.177-comp1
nchembio.252-comp1
penicillin g
potassium 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
3Penicillin G BenzathinePhase 326
4Penicillin G ProcainePhase 326
5Dermatologic AgentsPhase 34555
6Antibiotics, AntitubercularPhase 35971
7Anti-Bacterial AgentsPhase 39140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Male Circumcision for HIV Prevention in Rakai, UgandaCompletedNCT00425984Phase 3
2Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New GuineaActive, not recruitingNCT01955252Phase 3

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: chancroid

Genetic Tests for Chancroid

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Anatomical Context for Chancroid

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MalaCards organs/tissues related to Chancroid:

33
Skin, Lymph node, Breast, Lung, Bone, Heart, Endothelial

FMA organs/tissues related to Chancroid:

16
Skin of the genitals

Animal Models for Chancroid or affiliated genes

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MGI Mouse Phenotypes related to Chancroid:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4CD36, CD4, RPL31, WT1

Publications for Chancroid

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Articles related to Chancroid:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
A MDP model for breast and ovarian cancer intervention strategies for BRCA1/2 mutation carriers. (24771600)
2015
2
CNS lymphoma in a patient with Shwachman Diamond syndrome. (24307640)
2014
3
Alteration of plasma phospholipid fatty acid profile in patients with septic shock. (23954620)
2013
4
Comparative antimicrobial efficacy of Metapex, Metronidazole, BioPure MTAD, Aztreonam on Bacteroides fragilis and Propionibacterium acne. (23956535)
2013
5
Novel treatments of asthma and allergic diseases. (24287269)
2013
6
Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children's oncology group. (23440556)
2013
7
Utility of skin biopsy in management of small fiber neuropathy. (23553795)
2013
8
Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion. (22556336)
2012
9
Re: Laparoendoscopic single-site surgery versus conventional laparoscopic varicocele ligation in men with palpable varicocele: a randomized, clinical study. (23141269)
2012
10
ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth. (21725599)
2011
11
JAK2-V617F mutation in patients with myeloproliferative neoplasms: association with FLT3-ITD mutation]. (21180092)
2010
12
Purification and characterization of mammalian glucose transporters expressed in Pichia pastoris. (19883765)
2010
13
Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines. (19682499)
2009
14
Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner. (19366867)
2009
15
Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells. (18835323)
2008
16
Comparison of real time two-dimensional with live/real time three-dimensional transesophageal echocardiography in the evaluation of mitral valve prolapse and chordae rupture. (18986397)
2008
17
Prognostic significance of CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's Lymphoma]. (19000453)
2008
18
An unexpected new role of mutant Ras: perturbation of human embryonic development. (17211612)
2007
19
Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia. (17507447)
2007
20
Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism. (18000558)
2007
21
Partial hypoxanthine-guanine phosphoribosyl transferase deficiency without elevated urinary hypoxanthine excretion. (17129743)
2007
22
A medical therapy for aortic valve sclerosis and aortic valve stenosis? Rationale of the ASSIST study (Asymptomatic aortic Sclerosis/Stenosis: Influence of STatins): a large, observational, prospective, multicenter study of the Italian Society of Cardiovascular Echography. (16801806)
2006
23
A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. (16643654)
2006
24
Tachykinins and the control of prolactin secretion. (16930771)
2006
25
The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. (15958519)
2005
26
The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases: meta-analysis of randomized controlled clinical trials. (15511250)
2004
27
Potential adjunctive therapies in adolescents with type 1 diabetes mellitus. (15511128)
2004
28
Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. (14565825)
2003
29
Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia. (12163196)
2002
30
UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. (11928814)
2002
31
Non-inversion factor VIII mutations in 80 hemophilia A families including 24 with alloimmune responses. (11858487)
2002
32
Botulinum toxin treatment for spasmodic dysphonia: percutaneous versus transoral approach. (9617512)
1998
33
Vitronectin decreases microvascular endothelial cell apoptosis. (9525473)
1998
34
Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. (9703761)
1998
35
A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation. (9287331)
1997
36
Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter. (9016563)
1997
37
Cdc2 and mitogen-activated protein kinases modulate DNA binding properties of the putative transcriptional regulator Chironomus high mobility group protein I. (9341202)
1997
38
Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site. (8721682)
1996
39
Myocardial infarction and nitric oxide. (8901487)
1996
40
Characterization of the mouse gene for the alpha 1 chain of type XVIII collagen (Col18a1) reveals that the three variant N-terminal polypeptide forms are transcribed from two widely separated promoters. (8838808)
1996
41
A preliminary report of the safety and efficacy of fluvastatin for hypercholesterolemia in renal transplant patients receiving cyclosporine. (7604782)
1995
42
Prevalence of Borrelia burgdorferi antibodies in Bell's palsy in a metropolitan area of northern Italy. (10774420)
1994
43
Baculovirus-directed expression of human prostatic steroid 5 alpha-reductase 1 in an active form. (8664165)
1993
44
The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction. (8441379)
1993
45
Carrier detection and prenatal diagnosis of X-linked agammaglobulinemia. (1642281)
1992
46
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth. (1281201)
1992
47
M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture. (2352188)
1990
48
Molybdenum cofactor deficiency in a patient previously characterized as deficient in sulfite oxidase. (3219233)
1988
49
Anterior spinal artery syndrome with chronic traumatic aortic aneurysm. (7065767)
1982
50
Hyperglycinuria in a family with autosomal dominantly inherited cataract. (4430153)
1974

Variations for Chancroid

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Expression for genes affiliated with Chancroid

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Search GEO for disease gene expression data for Chancroid.

Pathways for genes affiliated with Chancroid

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Pathways related to Chancroid according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5CD36, CD4
29.5CD36, CD4

GO Terms for genes affiliated with Chancroid

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Biological processes related to Chancroid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:00327359.9CD36, HSPD1
2positive regulation of T cell activationGO:00508709.6CD4, HSPD1
3T cell activationGO:00421109.5CD4, HSPD1
4positive regulation of interleukin-6 productionGO:00327559.3CD36, HSPD1

Sources for Chancroid

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet