MCID: CHN002
MIFTS: 39

Chancroid

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Chancroid

MalaCards integrated aliases for Chancroid:

Name: Chancroid 12 72 49 51 41 14
Ulcus Molle, Skin 12
Chancroids 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13778
ICD10 32 A57
ICD9CM 34 099.0
MeSH 41 D002602
UMLS 69 C0007947

Summaries for Chancroid

NIH Rare Diseases : 49 Chancroid is a bacterial infection that is spread through sexual contact. It is caused by a type of bacteria called Haemophilus ducreyi. Chancroid is characterized by a small bump on the genital which becomes a painful ulcer. Men may have just one ulcer, but women often develop four or more. About half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. In some cases, the nodes will break through the skin and cause draining abscesses. The swollen lymph nodes and abscesses are often called buboes. Chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. Large lymph node swellings need to be drained, either with a needle or local surgery. Last updated: 12/4/2012

MalaCards based summary : Chancroid, also known as ulcus molle, skin, is related to lymphogranuloma venereum and granuloma inguinale, and has symptoms including painful An important gene associated with Chancroid is CD36 (CD36 Molecule), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Penicillin G and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, skin and lymph node.

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted_by sexual contact. The infection has symptom painful and soft ulcers.

Wikipedia : 72 Chancroid (/ˈʃæŋkrɔɪd/ SHANG-kroyd) (also known as soft chancre and ulcus molle) is a bacterial sexually... more...

Related Diseases for Chancroid

Diseases related to Chancroid via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 lymphogranuloma venereum 10.4
2 granuloma inguinale 10.4
3 syphilis 10.2
4 genital herpes 10.0
5 sennetsu fever 10.0 HSPD1 HSPE1
6 herpes simplex 10.0
7 leukodystrophy, hypomyelinating, 4 9.9 HSPD1 HSPE1
8 thrombasthenia 9.9 CD36 VTN
9 bartonellosis 9.9 HSPD1 HSPE1
10 carrion's disease 9.9 HSPD1 HSPE1
11 human immunodeficiency virus type 1 9.8
12 mungan syndrome 9.8
13 neutropenia 9.8
14 bacterial vaginosis 9.8
15 primary syphilis 9.8
16 molluscum contagiosum 9.8
17 mycobacterium gordonae 9.8 DLAT HSPD1
18 leprosy 3 9.7 HSPD1 HSPE1
19 mycobacterium tuberculosis 1 9.6 HSPD1 HSPE1

Graphical network of the top 20 diseases related to Chancroid:



Diseases related to Chancroid

Symptoms & Phenotypes for Chancroid

Symptoms:

12
  • painful

Drugs & Therapeutics for Chancroid

Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
2
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
3 Dermatologic Agents Phase 3
4 Penicillin G Benzathine Phase 3
5 Penicillin G Procaine Phase 3
6 Anti-Bacterial Agents Phase 3
7 Antibiotics, Antitubercular Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
2 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: chancroid

Genetic Tests for Chancroid

Anatomical Context for Chancroid

The Foundational Model of Anatomy Ontology organs/tissues related to Chancroid:

18
Skin Of The Genitals

MalaCards organs/tissues related to Chancroid:

38
Skin, Lymph Node, Testes, Cervix

Publications for Chancroid

Articles related to Chancroid:

(show top 50) (show all 273)
# Title Authors Year
1
2017 European guideline for the management of chancroid. ( 28081686 )
2017
2
Other sexually transmitted diseases chancroid and donovanosis. ( 27107782 )
2016
3
First case of chancroid in 14 years at the largest STI clinic in Paris, France. ( 26378189 )
2015
4
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. ( 24559566 )
2014
5
Chancroid - desperate patient makes own diagnosis. ( 24535694 )
2014
6
The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid. ( 24844153 )
2014
7
UK National Guideline for the management of chancroid 2014. ( 25080286 )
2014
8
Virtual screening of phytochemicals to novel targets in Haemophilus ducreyi towards the treatment of Chancroid. ( 25258485 )
2014
9
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. ( 22100216 )
2012
10
Etiologic pattern of genital ulcers in Lusaka, Zambia: has chancroid been eliminated? ( 23001266 )
2012
11
Chancroid transmission dynamics: a mathematical modeling approach. ( 21842439 )
2011
12
European guideline for the management of chancroid, 2011. ( 21571970 )
2011
13
Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid. ( 21646451 )
2011
14
Chancroid in an HIV-negative woman in the Midwestern United States. ( 19926434 )
2011
15
A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin. ( 20191200 )
2009
16
Chancroid and human immunodeficiency virus infection--a review. ( 18173591 )
2008
17
Cutaneous chancroid in a visitor from Vanuatu. ( 18412810 )
2008
18
Chancroid. ( 17151046 )
2006
19
Co-occurrence of chancroid and gonorrhea. ( 17241572 )
2006
20
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. ( 16552053 )
2006
21
Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid. ( 16622201 )
2006
22
Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. ( 16581731 )
2006
23
Treatment of chancroid in resource-poor countries. ( 15918786 )
2005
24
The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid. ( 15876546 )
2005
25
Chancroid: contemporary appraisal. ( 12653911 )
2003
26
Specificity of antibodies directed against the cytolethal distending toxin of Haemophilus ducreyi in patients with chancroid. ( 12927521 )
2003
27
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. ( 14636203 )
2003
28
Chancroid: clinical manifestations, diagnosis, and management. ( 12576620 )
2003
29
Immunopathogenesis of Haemophilus ducreyi infection (chancroid). ( 11895928 )
2002
30
Erythema nodosum induced by chancroid. ( 12407252 )
2002
31
Chancroid: an update. ( 17656857 )
2002
32
Eradicating chancroid. ( 11584729 )
2001
33
Update on the experimental human model for chancroid infection. ( 10667906 )
2000
34
Chancroid in the United Kingdom. ( 10858704 )
2000
35
Thiamphenicol in the treatment of chancroid. A study of 1,128 cases. ( 10887371 )
2000
36
Chancroid: from clinical practice to basic science. ( 12240879 )
2000
37
Diagnostic tests for chancroid. ( 10858718 )
2000
38
Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. ( 10479178 )
1999
39
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. ( 9884340 )
1999
40
Treatment of chancroid, 1997. ( 10028106 )
1999
41
Immune cells are required for cutaneous ulceration in a swine model of chancroid. ( 10456960 )
1999
42
National guideline for the management of chancroid. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). ( 10616383 )
1999
43
The use of experimental animal and human models in the study of chancroid pathogenesis. ( 10215110 )
1999
44
Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid. ( 10496915 )
1999
45
A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya. ( 10558945 )
1999
46
A comparative study of therapeutic response of patients with clinical chancroid to ciprofloxacin, erythromycin, and cotrimoxazole. ( 9662762 )
1998
47
An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection. ( 9806035 )
1998
48
Chancroid. ( 21390754 )
1998
49
Comparison of culture media for the laboratory diagnosis of chancroid. ( 9822303 )
1998
50
Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States. ( 9180178 )
1997

Variations for Chancroid

Expression for Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for Chancroid

Pathways related to Chancroid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 VTN WT1

GO Terms for Chancroid

Cellular components related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 8.8 DLAT HSPD1 HSPE1

Biological processes related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 CD36 VTN
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.32 HSPD1 HSPE1
3 response to unfolded protein GO:0006986 9.26 HSPD1 HSPE1
4 positive regulation of interleukin-6 production GO:0032755 9.16 CD36 HSPD1
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.96 CD36 HSPD1
6 positive regulation of interleukin-12 production GO:0032735 8.62 CD36 HSPD1

Molecular functions related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.56 HSPD1 HSPE1 RPL31 WT1
2 unfolded protein binding GO:0051082 9.32 HSPD1 HSPE1
3 chaperone binding GO:0051087 9.16 HSPD1 HSPE1
4 scavenger receptor activity GO:0005044 8.96 CD36 VTN
5 high-density lipoprotein particle binding GO:0008035 8.62 CD36 HSPD1

Sources for Chancroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....