Summaries for Chancroid

Sources:
6Disease Ontology, 30NIH Rare Diseases, 44Wikipedia, 22MalaCards
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NIH Rare Diseases: Chancroid is a bacterial infection that is spread through sexual contact. It is caused by a type of bacteria called Haemophilus ducreyi. Chancroid is characterized by a small bump on the genital which becomes a painful ulcer. Men may have just one ulcer, but women often develop four or more. About half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. In some cases, the nodes will break through the skin and cause draining abscesses. The swollen lymph nodes and abscesses are often called buboes. Chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. Large lymph node swellings need to be drained, either with a needle or local surgery.30

MalaCards: Chancroid, also known as chancroid (disorder), is related to syphilis and trachoma, and has symptoms including painful An important gene associated with Chancroid is CDB2 (corneal dystrophy of Bowman layer type II (Thiel-Behnke)). The drugs erythromycin pwdr [va product] and erythromycin estolate and the compounds pyruvate and cysteine have been mentioned in the context of this disorder. Affiliated tissues include skin of the genitals, lymph node and skin.

Disease Ontology: A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in haemophilus ducreyi, which is transmitted by sexual contact. the infection has symptom painful and soft ulcers.6

Wikipedia: Chancroid (also known as soft chancre and ulcus molle) is a bacterial sexually transmitted infection...44 more...

Aliases & Descriptions for Chancroid

Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM
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Aliases & Descriptions:

chancroid 6 30 8 32
chancroid (disorder) 6
chancroid & bubo 6
ulcus molle, skin 6
ducrey's chancre 6
chancroids 43

External Ids:

SNOMED-CT40 266213004, 154391003, 266143009 87429008, 186945008, more
ICD9CM19 099.0

Related Diseases for Chancroid

Sources:
13GeneCards, 14GeneDecks
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Diseases related to chancroid by text searches and GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis12.6WARS, WT1
2trachoma12.3WARS, HSPD1
3pancytopenia12.1WT1, GBA
4connective tissue disease12.0CD36, HSPD1
5neurodegeneration11.5GBA, HGS, HSPD1, WARS
6cataract11.4PRDX6, WT1, HSPD1, CD36
7down syndrome11.2PRDX6, WT1, HSPD1, CD36
8twinning11.2CD36, HSPD1, WT1, GBA
9myeloma10.7GBA, WT1, HSPD1, CD36, WARS
10alzheimer's disease10.4PRDX6, WT1, HSPD1, CD36, CMAS, WARS
11adenocarcinoma10.2HGS, PRDX6, WT1, HSPD1, CD36, WARS

Graphical network of the top 20 diseases related to chancroid:



Graphical network of diseases related to chancroid

Clinical Features for Chancroid

Sources:
6Disease Ontology
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Symptoms: painful.6

Drugs & Therapeutics for Chancroid

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for chancroid

Drug clinical trials:

Search ClinicalTrials for chancroid

Search NIH Clinical Center for chancroid

Search CenterWatch for chancroid

Inferred drug relations via UMLS/NDF-RT:

43 28 ceftriaxone, ceftriaxone sodium, erythromycin, erythromycin estolate, erythromycin ethylsuccinate, erythromycin gluceptate, erythromycin lactobionate, erythromycin pwdr [va product], erythromycin stearate

Genetic Tests for Chancroid

Anatomical Context for Chancroid

Sources:
11FMA, 22MalaCards
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MalaCards organs/tissues related to chancroid:

22
Lymph node, Skin

FMA organs/tissues related to chancroid:

11
Skin of the genitals

Phenotypes for genes affiliated with Chancroid

Publications for genes affiliated with Chancroid

Sources:
35PubMed
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Articles related to chancroid:

idTitleAuthorsYearAffiliating Genes
1Expression of Haemophilus ducreyi collagen binding ou ter membrane protein NcaA is required for virulence in swine and human challeng e models of chancroid. (16622201)Fulcher R.A.... Kawula T.H.2006CD36

Expression for genes affiliated with Chancroid

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Chancroid

Pathways for genes affiliated with Chancroid

Compounds for genes affiliated with Chancroid

Sources:
32Novoseek
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Compounds related to chancroid according to GeneDecks:

idCompoundScoreTop Affiliating Genes
1pyruvate32 8.9HSPD1, PRDX6, GBA
2cysteine32 7.3CD36, HSPD1, WT1, PRDX6, GBA

GO Terms for genes affiliated with Chancroid

Sources:
12Gene Ontology
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Biological processes related to chancroid according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:0327559.0CD36, HSPD1
2positive regulation of interleukin-12 productionGO:0327358.7CD36, HSPD1

Sources for Chancroid

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS