Aliases & Classifications for Cheilitis

Aliases & Descriptions for Cheilitis:

Name: Cheilitis 12 29 14

Classifications:



External Ids:

Disease Ontology 12 DOID:1762
ICD10 33 K13.0
MeSH 42 D002613
NCIt 47 C79545
UMLS 69 C0007971

Summaries for Cheilitis

Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to angular cheilitis and cheilitis glandularis. An important gene associated with Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are TNFR1 Pathway and Apoptosis Modulation and Signaling. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 71 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
id Related Disease Score Top Affiliating Genes
1 angular cheilitis 12.3
2 cheilitis glandularis 12.2
3 actinic cheilitis 12.2
4 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.1
5 melkersson-rosenthal syndrome 11.7
6 orofacial granulomatosis 11.1
7 immunodeficiency 12 10.8
8 actinic prurigo polymorphic light eruption, hereditary 10.8
9 rommen mueller sybert syndrome 10.3 MDM2 TP53
10 functionless pituitary adenoma 10.3 MDM2 TP53
11 breast epithelioid hemangioma 10.2 CDKN1A TP53
12 inverted follicular keratosis 10.2 CDKN1A TP53
13 familial hypopituitarism 10.2 MSH2 TP53
14 perineural angioma 10.2 CDKN1A TP53
15 endometrial squamous cell carcinoma 10.2 MDM2 TP53
16 crohn's disease 10.2
17 squamous cell carcinoma 10.2
18 aorta atresia 10.1 MMP9 MSH2
19 urinary tract obstruction 10.1 CDKN1A MDM2
20 cervical verrucous carcinoma 10.1 CDKN1A MDM2 TP53
21 extraocular retinoblastoma 10.1 CDKN1A MDM2 TP53
22 integumentary system benign neoplasm 10.1 CDKN1A MDM2 TP53
23 post-surgical hypoinsulinemia 10.1 CDKN1A MDM2 TP53
24 malignant spindle cell melanoma 10.1 CDKN1A MSH2 TP53
25 hidradenoma 10.1 MDM2 MSH2 TP53
26 nasopharyngeal carcinoma 10.1 CDKN1A MDM2 TP53
27 thoracic outlet syndrome 10.1 CDKN1A MDM2 TP53
28 prostate cancer, hereditary, x-linked 1 10.1 CDKN1A MSH2 TP53
29 brain meningioma 10.1 MMP9 TP53
30 house allergic alveolitis 10.1 MDM2 TP53
31 dysembryoplastic neuroepithelial tumor 10.1 CDKN1A MSH2 TP53
32 thanatophoric dysplasia, type ii 10.1 CDKN1A MDM2 TP53
33 coronary stenosis 10.1 MDM2 TP53
34 glucose-6-phosphate translocase deficiency 10.1 CDKN1A MDM2 TP53
35 epithelioid malignant peripheral nerve sheath tumor 10.1 MMP9 SERPINB5
36 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 10.1 MDM2 MMP9 TP53
37 maxillary sinus cholesteatoma 10.1 CDKN1A MMP9 TP53
38 lattice corneal dystrophy 10.1 CDKN1A MMP9 TP53
39 lymphangitis 10.1 KRT6A TMEM79 TP53
40 dermatitis 10.1
41 cholesteatoma of middle ear 10.0 KRT6A TMEM79
42 mediastinum angiosarcoma 10.0 MDM2 SERPINB5 TP53
43 hypotrichosis 8 10.0 MDM2 MMP9 TP53
44 glucosephosphate isomerase deficiency 10.0 MDM2 MMP9 TP53
45 brain stem medulloblastoma 10.0 SERPINB5 TP53
46 brain stem angioblastoma 10.0 MDM2 TP53
47 muscular dystrophy-dystroglycanopathy , type b, 2 10.0 CDKN1A MDM2 MSH2 TP53
48 spastic paraplegia 1 10.0 MDM2 TNF TP53
49 papilledema 9.9 KRT6A TNF
50 in situ pulmonary adenocarcinoma 9.9 CDKN1A MDM2 MMP9 TP53

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis

Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDKN1A MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 MSH2 SERPINB5 SUMO1 TNF TP53 CAST
2 growth/size/body region MP:0005378 10.01 CDKN1A MDM2 MMP9 SERPINB5 SUMO1 TMEM79
3 digestive/alimentary MP:0005381 9.98 CDKN1A MDM2 MMP9 MSH2 SUMO1 TNF
4 hematopoietic system MP:0005397 9.97 TMEM79 TNF TP53 CAST CDKN1A MDM2
5 immune system MP:0005387 9.92 CAST CDKN1A MDM2 MMP9 MSH2 TMEM79
6 adipose tissue MP:0005375 9.89 CDKN1A SERPINB5 TMEM79 TNF TP53
7 craniofacial MP:0005382 9.85 CDKN1A MDM2 SUMO1 TNF TP53
8 integument MP:0010771 9.8 CDKN1A MDM2 MMP9 MSH2 TMEM79 TNF
9 limbs/digits/tail MP:0005371 9.63 CAST CDKN1A MDM2 MMP9 TNF TP53
10 mortality/aging MP:0010768 9.61 CAST CDKN1A MDM2 MMP9 MSH2 SERPINB5
11 neoplasm MP:0002006 9.1 CDKN1A MDM2 MMP9 MSH2 TNF TP53

Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Interferon Inducers Phase 4
5 interferons Phase 4
6 Methyl 5-aminolevulinate Phase 4,Phase 1
7 Dermatologic Agents Phase 4,Phase 1
8 Photosensitizing Agents Phase 4,Phase 1
9
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
10 Calcineurin Inhibitors Phase 2
11 Immunosuppressive Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4
4 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

id Genetic test Affiliating Genes
1 Cheilitis 29

Anatomical Context for Cheilitis

MalaCards organs/tissues related to Cheilitis:

39
Skin, Testes, Salivary Gland, T Cells, Tongue

Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 536)
id Title Authors Year
1
Allergic contact cheilitis in children and improvement with patch testing. ( 28050593 )
2017
2
Allergic contact cheilitis caused by olaflur in toothpaste. ( 27957754 )
2017
3
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
4
Cheilitis glandularis: Case report with respect to immunohistochemical findings. ( 26816670 )
2016
5
Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. ( 27502182 )
2016
6
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
7
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
8
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
9
Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report. ( 27385520 )
2016
10
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. ( 26981737 )
2016
11
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
12
Allergic contact cheilitis and hand dermatitis caused by a toothpaste. ( 26899811 )
2016
13
Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone. ( 27628958 )
2016
14
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
15
Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease. ( 27017505 )
2016
16
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
17
A case of allergic contact cheilitis caused by propolis and honey. ( 26899810 )
2016
18
Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products. ( 27003364 )
2016
19
Glycerin Borax Treatment of Exfoliative Cheilitis Induced by Sodium Lauryl Sulfate: a Case Report. ( 27789914 )
2016
20
Cheilitis granulomatosa. ( 27990408 )
2016
21
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
22
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
23
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
24
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
25
Granulomatous Cheilitis Associated With Crohn's Disease. ( 27125706 )
2016
26
Clinically granulomatous cheilitis with plasma cells. ( 27057489 )
2016
27
Clinical features, cytology and bacterial culture results in dogs with and without cheilitis and comparison of three sampling techniques. ( 27019393 )
2016
28
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
29
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
30
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
31
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
32
Resident Rounds: Part III - Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis. ( 26885796 )
2016
33
Cheilitis caused by to mint-containing toothpastes. ( 27620130 )
2016
34
Granulomatous cheilitis: a stiff upper lip. ( 26562278 )
2015
35
Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. ( 25683118 )
2015
36
Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature. ( 26164836 )
2015
37
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
38
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015
39
Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale. ( 26395167 )
2015
40
Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy. ( 26568994 )
2015
41
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2015
42
Favorable response to composite treatment including infliximab in a case of granulomatous cheilitis with Crohn's disease. ( 25809090 )
2015
43
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2015
44
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
45
Leishmaniasis recidiva cutis of the lips mimicking granulomatous cheilitis. ( 25814756 )
2015
46
Contact allergy in cheilitis. ( 26547761 )
2015
47
Granulomatous cheilitis with intralymphatic histiocytosis possibly associated with calcium deposition caused by chronic inflammation owing to dental metals and periodontitis. ( 25482731 )
2015
48
Chronic cheilitis caused by acrylates used as an adhesive for an orthodontic brace. ( 25603970 )
2015
49
Lip Lesions: Lichen Planus vs. Solar Cheilitis. ( 26146909 )
2015
50
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015

Variations for Cheilitis

Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 50)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 MMP9 SUMO1 TNF TP53
2
Show member pathways
12.7 CDKN1A MDM2 TNF TP53
3
Show member pathways
12.56 CDKN1A MDM2 MSH2 TP53
4
Show member pathways
12.53 CDKN1A MDM2 SUMO1 TP53
5 12.5 CDKN1A MDM2 MMP9 MSH2 TP53
6
Show member pathways
12.47 CDKN1A MSH2 TNF TP53
7 12.37 CDKN1A MDM2 MSH2 TP53
8 12.33 CDKN1A MDM2 MMP9 SERPINB5 TP53
9
Show member pathways
12.25 CDKN1A MDM2 SERPINB5 TP53
10
Show member pathways
12.23 CDKN1A MDM2 MSH2 TP53
11
Show member pathways
12.2 CDKN1A MDM2 TP53
12 12.19 CDKN1A MDM2 TP53
13 12.18 CDKN1A MDM2 TP53
14
Show member pathways
12.14 CDKN1A MDM2 TP53
15 12.1 CDKN1A MDM2 MMP9 TP53
16
Show member pathways
12.08 CDKN1A MDM2 TP53
17 12.07 CDKN1A MDM2 MMP9 TNF TP53
18 12.04 MDM2 MSH2 TP53
19 12.01 CDKN1A MDM2 TP53
20
Show member pathways
11.99 CDKN1A MDM2 TP53
21 11.97 CDKN1A SUMO1 TP53
22 11.96 CDKN1A TNF TP53
23 11.94 MMP9 SUMO1 TNF TP53
24 11.94 CDKN1A MMP9 MSH2 TNF TP53
25 11.92 MMP9 TNF TP53
26 11.89 CDKN1A MDM2 TP53
27 11.87 CDKN1A MDM2 TP53
28 11.84 CDKN1A MDM2 TP53
29 11.84 CDKN1A MMP9 TNF TP53
30 11.76 CDKN1A MDM2 SUMO1
31 11.74 CDKN1A MDM2 TP53
32
Show member pathways
11.73 CDKN1A MDM2 TP53
33 11.69 CDKN1A MDM2 TP53
34 11.68 CDKN1A MDM2 MSH2 SERPINB5 TP53
35 11.6 CDKN1A MDM2 MMP9 TP53
36 11.57 CDKN1A MDM2 MSH2 TP53
37 11.56 CDKN1A MDM2 SUMO1 TP53
38
Show member pathways
11.48 MDM2 SUMO1 TP53
39 11.47 CDKN1A MDM2 MSH2 SERPINB5 TP53
40 11.44 CDKN1A TNF TP53
41 11.36 CDKN1A MDM2 TP53
42 11.22 CDKN1A MDM2 MSH2 TP53
43 11.21 CDKN1A TP53
44 11.21 MDM2 TP53
45 11.19 MDM2 TP53
46 11.02 MDM2 TP53
47 10.72 CDKN1A TP53
48 10.67 MDM2 SUMO1
49
Show member pathways
10.49 CDKN1A TP53
50
Show member pathways
10.27 CDKN1A MDM2 SUMO1 TP53

GO Terms for Cheilitis

Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 8.92 CDKN1A MDM2 SUMO1 TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.87 MDM2 SUMO1 TNF TP53
2 negative regulation of apoptotic process GO:0043066 9.85 CDKN1A MDM2 MMP9 TP53
3 extracellular matrix organization GO:0030198 9.79 MMP9 SERPINB5 TNF
4 negative regulation of gene expression GO:0010629 9.73 CDKN1A MDM2 TNF
5 cell cycle arrest GO:0007050 9.7 CDKN1A MSH2 TP53
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.61 CDKN1A TP53
7 cellular response to ionizing radiation GO:0071479 9.6 CDKN1A TP53
8 cellular response to cadmium ion GO:0071276 9.59 MMP9 SUMO1
9 intrinsic apoptotic signaling pathway GO:0097193 9.58 CDKN1A TP53
10 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.58 MMP9 TP53
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.58 CDKN1A MDM2 TP53
12 positive regulation of protein complex assembly GO:0031334 9.54 SUMO1 TNF
13 positive regulation of protein export from nucleus GO:0046827 9.51 MDM2 TP53
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 CDKN1A TP53
15 determination of adult lifespan GO:0008340 9.48 MSH2 TP53
16 replicative senescence GO:0090399 9.46 CDKN1A TP53
17 positive regulation of programmed cell death GO:0043068 9.43 CDKN1A TNF
18 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.43 CDKN1A MSH2 TP53
19 signal transduction by p53 class mediator GO:0072331 9.37 CDKN1A TP53
20 cellular response to gamma radiation GO:0071480 9.33 CDKN1A MDM2 TP53
21 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
22 response to X-ray GO:0010165 9.13 CDKN1A MSH2 TP53
23 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MDM2 MMP9 TNF

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 MDM2 MMP9 TMEM79 TNF TP53
2 disordered domain specific binding GO:0097718 9.37 MDM2 TP53
3 SUMO transferase activity GO:0019789 9.32 MDM2 SUMO1
4 enzyme binding GO:0019899 9.26 MDM2 MSH2 SUMO1 TP53
5 ubiquitin protein ligase binding GO:0031625 8.92 CDKN1A MDM2 SUMO1 TP53
6 protein binding GO:0005515 10 CAST CDKN1A KRT6A MDM2 MMP9 MSH2

Sources for Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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