Aliases & Classifications for Cheilitis

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Aliases & Descriptions for Cheilitis:

Name: Cheilitis 11 13 25 66

Classifications:



External Ids:

Disease Ontology11 DOID:1762
ICD1028 K13.0
MeSH37 D002613
NCIt43 C79545

Summaries for Cheilitis

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Disease Ontology:11 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary: Cheilitis is related to oral lichen planus and angular cheilitis, and has symptoms including dry skin, warm skin and burning sensation of skin. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Oncogene Induced Senescence. Affiliated tissues include skin, breast and testes, and related mouse phenotypes are neoplasm and limbs/digits/tail.

Wikipedia:69 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1oral lichen planus29.3MMP9, TP53
2angular cheilitis12.3
3cheilitis glandularis12.3
4actinic cheilitis12.2
5peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads12.1
6melkersson-rosenthal syndrome11.6
7orofacial granulomatosis10.6
8chromosome 7p duplication10.6MDM2, TP53
9median neuropathy10.6MDM2, TP53
10pylorus cancer10.6MALT1, TP53
11ampulla of vater squamous cell carcinoma10.5MDM2, TP53
12prostate calculus10.5MDM2, TP53
13familial renal oncocytoma10.5FGFR3, TP53
14kidney sarcoma10.5MDM2, TP53
15scrapie10.5FGFR3, TP53
16intrahepatic bile duct adenoma10.5FGFR3, TP53
17vaginal yolk sac tumor10.5MDM2, TP53
18bile duct disease10.5MDM2, TP53
19bladder verrucous squamous cell carcinoma10.5MDM2, TP53
20stampe sorensen syndrome10.5MDM2, TP53
21spinal cord glioma10.5MDM2, TP53
22early myoclonic encephalopathy10.5MDM2, TP53
23hypoglossal nerve neoplasm10.5MDM2, TP53
24emerinopathy10.4MDM2, TP53
25hypersensitivity reaction type iv disease10.4FGFR3, TP53
26colver steer godman syndrome10.4MSH2, TP53
27vulvar sebaceous carcinoma10.4MDM2, TP53
28multidrug-resistant tuberculosis10.4FGFR3, TP53
29central nervous system rhabdomyosarcoma10.4MDM2, TP53
30clove syndrome, somatic10.3FGFR3, TP53
31l-cell glucagon-like peptide producing tumor10.3MSH2, TP53
32crohn's disease10.3
33drug-induced hepatitis10.3MALT1, MDM2, TP53
34grade iii astrocytoma10.2FGFR3, MDM2, TP53
35periapical granuloma10.2MSH2, TP53
36dermatitis10.2
37smoking as a quantitative trait locus 110.2MALT1, MDM2, TP53
38ladd syndrome10.1FGFR3, MDM2, TP53
39cervical cancer, somatic10.1FGFR3, MDM2, TP53
40brain ischemia10.1MMP9, TP53
41prostate embryonal rhabdomyosarcoma10.1MDM2, MSH2, TP53
42stomatitis10.1
43prostate cancer, hereditary, x-linked 110.1FGFR3, MSH2, TP53
44hidrocystoma10.1MDM2, MSH2, TP53
45malignant giant cell tumor of the tendon sheath10.0MMP9, TP53
46contact dermatitis10.0
47vulvitis10.0
48multiple carboxylase deficiency10.0MDM2, SUMO1, TP53
49antidepressant or antipsychotic toxicity or dose selection10.0MMP9, TP53
50acne10.0

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to cheilitis

Symptoms for Cheilitis

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UMLS symptoms related to Cheilitis:


dry skin, warm skin, burning sensation of skin, pain of skin, macule, chapping of lips, peau d'orange surface of breast, sore lip, macerated skin (finding), yellow complexion, rash lips, pigmentation lip, lip redness, skin discomfort, painful scar, application site papules, oral mucosa atrophy, eyelid margin crusting, eyelid pain, injection site dryness, eyelid skin dryness, pathergy reaction

Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aminolevulinic acidPhase 4, Phase 1150106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
2interferonsPhase 42112
3
ImiquimodPhase 413599011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
ZINC19632912
Zartra
Zyclara
imiquimod
4
TacrolimusPhase 21058104987-11-3445643, 439492
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
Anhydrous tacrolimus
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
 
FR900506
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus anhydrous
Tacrolimus hydrate
Tacrolimus, anhydrous
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's DiseaseCompletedNCT01233570Phase 2
5Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

id Genetic test Affiliating Genes
1 Cheilitis25

Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

34
Skin, Breast, Testes, Salivary gland, Tongue, T cells

Animal Models for Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Cheilitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5FGFR3, MDM2, MMP9, MSH2, TP53
2MP:00053718.5CAST, FGFR3, MDM2, MMP9, TP53
3MP:00053817.8FGFR3, MDM2, MMP9, MSH2, SUMO1, TP53
4MP:00053877.5CAST, FGFR3, MALT1, MDM2, MMP9, MSH2
5MP:00053977.3CAST, FGFR3, MALT1, MDM2, MMP9, MSH2
6MP:00053847.2CAST, FGFR3, MDM2, MMP9, MSH2, SERPINB5
7MP:00107686.7CAST, FGFR3, MDM2, MMP9, MSH2, SERPINB5

Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Resident Rounds: Part III - Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis. (26885796)
2016
2
Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products. (27003364)
2016
3
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
4
Isotretinoin and Vitiligo: Can Chronic Cheilitis Cause Koebnerization? (25781892)
2015
5
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
6
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. (25039599)
2014
7
How do I manage a patient with angular cheilitis? (23763743)
2013
8
Granulomatous cheilitis with granulomatous vulvitis: a rare association. (24177613)
2013
9
Contact cheilitis caused by candelilla wax contained in lipstick. (23869737)
2013
10
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
11
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
12
Cheilitis glandularis: clinico-histopathological diagnostic criteria. (21029266)
2011
13
Successful treatment of cheilitis granulomatosa with intralesional injection of triamcinolone. (19845820)
2010
14
Actinic cheilitis: a treatment review. (20964646)
2010
15
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
16
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
17
Successful treatment of plasma cell cheilitis with topical calcineurin inhibitors. (19958456)
2009
18
Cheilitis glandularis progressing to squamous cell carcinoma in an hiv-infected patient: case report. (18402312)
2007
19
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. (17640230)
2007
20
Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa. (16172304)
2005
21
Cheilitis granulomatosa of Melkersson-Rosenthal syndrome: treatment with intralesional corticosteroid injections. (14980194)
2004
22
Cheilitis glandularis: a case report. (15040488)
2004
23
Exfoliative cheilitis successfully treated with topical tacrolimus. (15270904)
2004
24
Miescher's cheilitis granulomatosa. A presentation of five cases. (15580120)
2004
25
Case report: exfoliative cheilitis managed with antidepressant medication. (15612458)
2004
26
Cheilitis glandularis: an unusual histopathologic presentation. (12627102)
2003
27
A yoga teacher with persistent cheilitis. (12800469)
2003
28
Nickel-induced angular cheilitis due to orthodontic braces. (12868984)
2003
29
Cheilitis granulomatosa: overview of 13 patients with long-term follow-up--results of management. (12066767)
2002
30
Eruptive cheilitis: a new adverse effect in reactive HIV-positive patients subjected to high activity antiretroviral therapy (HAART). Presentation of six clinical cases. (11488127)
2001
31
Recurrent allergic contact dermatitis and cheilitis due to castor oil. (10703646)
2000
32
Acquired linear anetoderma following angular cheilitis. (9666860)
1998
33
Actinic cheilitis. A treatment review. (9107289)
1997
34
Ulcerous granulomatous cheilitis with lymphatic invasion caused by Scopulariopsis brevicaulis infection. (7962740)
1994
35
Allergic contact cheilitis related to university studies. (8088159)
1994
36
Treatment of plasma cell cheilitis with griseofulvin. (8176022)
1994
37
Actinic cheilitis. (8308614)
1993
38
Cheilitis glandularis. (9791264)
1992
39
Minocycline in granulomatous cheilitis: experience with 6 cases. (1446091)
1992
40
Oral medicine in practice: angular cheilitis. (2069827)
1991
41
Carbon dioxide laser vermilionectomy for chronic actinic cheilitis. (2487875)
1989
42
Kveim test reactivity in Melkersson-Rosenthal syndrome (cheilitis granulomatosa). (2416173)
1985
43
Cheilitis glandularis--a disorder of ductal ectasia. (3980837)
1985
44
Phototoxic and contact toxic reactions of the exocarp of sweet oranges: a common cause of cheilitis? (6861482)
1983
45
Cheilitis glandularis. (6930075)
1980
46
Photosensitive cheilitis. Clinical and pathogenetic considerations. (5134900)
1971
47
Cheilitis glandularis. (5091868)
1971
48
Denture sore mouth and angular cheilitis--a case report and review of literature. (5268428)
1970
49
Cheilitis due to coffee. (13079301)
1953
50
Case of Cheilitis. (19982214)
1922

Variations for Cheilitis

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Expression for genes affiliated with Cheilitis

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Search GEO for disease gene expression data for Cheilitis.

Pathways for genes affiliated with Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.8MDM2, TP53
29.8MDM2, TP53
39.8MDM2, TP53
4
Show member pathways
9.7MSH2, TP53
5
Show member pathways
9.7MDM2, SUMO1
6
Show member pathways
9.4MDM2, MSH2, TP53
7
Show member pathways
9.4MDM2, MSH2, TP53
89.4MDM2, MSH2, TP53
9
Show member pathways
9.4MDM2, SUMO1, TP53
109.4MDM2, SUMO1, TP53
119.4MDM2, SUMO1, TP53
129.3MDM2, MMP9, TP53
139.3MDM2, MMP9, TP53
14
Show member pathways
9.3FGFR3, MDM2, TP53
159.2MMP9, MSH2, TP53
16
Show member pathways
9.2MDM2, SERPINB5, TP53
17
Show member pathways
8.8FGFR3, MMP9, SERPINB5
18
Show member pathways
8.8MDM2, MSH2, SERPINB5, TP53
198.8MDM2, MSH2, SERPINB5, TP53
208.8FGFR3, MDM2, MMP9, TP53
218.4FGFR3, MDM2, MMP9, MSH2, TP53
228.1FGFR3, MDM2, MMP9, SERPINB5, TP53

GO Terms for genes affiliated with Cheilitis

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Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.4MDM2, SUMO1, TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1determination of adult lifespanGO:000834010.3MSH2, TP53
2negative regulation of cell cycle arrestGO:007115710.3CAST, MDM2
3positive regulation of protein export from nucleusGO:004682710.2MDM2, TP53
4response to X-rayGO:001016510.2MSH2, TP53
5response to antibioticGO:004667710.1MDM2, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0MSH2, TP53
7protein sumoylationGO:00169259.8MDM2, SUMO1, TP53
8positive regulation of vascular smooth muscle cell proliferationGO:19047079.6MDM2, MMP9
9positive regulation of release of cytochrome c from mitochondriaGO:00902009.3MMP9, TP53
10negative regulation of apoptotic processGO:00430668.5MALT1, MDM2, MMP9, TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.5CAST, MALT1, TP53
2protein bindingGO:00055155.8CAST, FGFR3, KRT6A, MALT1, MDM2, MMP9

Sources for Cheilitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet