Aliases & Classifications for Cheilitis

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Aliases & Descriptions for Cheilitis:

Name: Cheilitis 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:1762
ICD1027 K13.0
MeSH36 D002613
NCIt42 C79545
UMLS65 C0007971

Summaries for Cheilitis

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Disease Ontology:10 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary: Cheilitis is related to factitious disorder and angular cheilitis, and has symptoms including pathergy reaction, eyelid skin dryness and injection site dryness. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Aurora A signaling. Affiliated tissues include skin, breast and prostate, and related mouse phenotypes are digestive/alimentary and cellular.

Wikipedia:68 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1factitious disorder24.3CAST, IFNA2, KRT10, KRT16, KRT6A, MDM2
2angular cheilitis12.3
3cheilitis glandularis12.2
4actinic cheilitis12.2
5peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads12.1
6peeling skin-leukonuchia-acral punctate keratoses-cheilitis-knuckle pads syndrome11.9
7melkersson-rosenthal syndrome11.6
8subglottic angioma10.7MDM2, TP53
9spindle cell liposarcoma10.6MDM2, TP53
10chronic duodenal ileus10.6MDM2, TP53
11middle ear squamous cell carcinoma10.6MDM2, TP53
12pulmonary immaturity10.6MDM2, TP53
13familial congenital fourth cranial nerve palsy10.6MSH2, TP53
14common bile duct disease10.6MDM2, TP53
15myocardium cancer10.6KRT6A, TP53
16soft tissue sarcoma childhood10.6MDM2, TP53
17merrf syndrome10.5MDM2, TP53
18schwannoma of twelfth cranial nerve10.5MDM2, TP53
19colonic l-cell glucagon-like peptide producing tumor10.5MSH2, TP53
20sebaceous breast carcinoma10.5MDM2, TP53
21breast adenomyoepithelial adenosis10.5MDM2, TP53
22liver rhabdomyosarcoma10.5MDM2, TP53
23lipomatosis10.5MSH2, TP53
24anterior spinal artery syndrome10.4MDM2, TP53
25autosomal dominant complex spastic paraplegia type 9a10.4MMP9, TP53
26hypertensive heart disease10.4KRT16, KRT6A
27adult astrocytic tumour10.4MDM2, TP53
28vulvar clear cell hidradenocarcinoma10.3KRT10, TP53
29crohn's disease10.3
30bacterial vaginosis10.3MDM2, MSH2, TP53
31benign mesenchymoma10.3KRT10, TP53
32herpes simplex10.3MDM2, SUMO1, TP53
33placental insufficiency10.2MDM2, MSH2, TP53
34juvenile astrocytoma10.2MDM2, TP53
35clove syndrome, somatic10.2KRT10, TP53
36hepatocellular adenoma10.2MDM2, MMP9, TP53
37homocystinuria10.2MMP9, TP53
38cell type cancer10.2MDM2, MMP9, TP53
39small cell cancer of the lung, somatic10.2MDM2, MMP9, TP53
40chancroid10.2IFNA2, TP53
41dermatitis10.2
42gliosarcoma10.2MDM2, MMP9, TP53
43hypothalamic disease10.2MMP9, MSH2, TP53
44tenosynovitis of foot and ankle10.2MMP9, MSH2, TP53
45cervical endometrial stromal sarcoma10.2MDM2, SERPINB5, TP53
46gliomatosis peritonei10.2MDM2, MMP9, TP53
47cervical cancer, somatic10.1MDM2, MMP9, TP53
48sclerosteosis 110.1KRT10, KRT16
49stomatitis10.1
50bowenoid papulosis10.1KRT10, KRT16

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to cheilitis

Symptoms for Cheilitis

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UMLS symptoms related to Cheilitis:


pathergy reaction, eyelid skin dryness, injection site dryness, eyelid pain, eyelid margin crusting, oral mucosa atrophy, application site papules, painful scar, skin discomfort, lip redness, pigmentation lip, rash lips, yellow complexion, macerated skin (finding), sore lip, peau d'orange surface of breast, chapping of lips, macule, pain of skin, burning sensation of skin, warm skin, dry skin

Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Imiquimodapproved, investigationalPhase 413199011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
I06-0624
 
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
imiquimod
2
Aminolevulinic acidapprovedPhase 4, Phase 1142106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulan Kerastick
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
3Immunologic FactorsPhase 4, Phase 218483
4Photosensitizing AgentsPhase 4, Phase 1374
5Adjuvants, ImmunologicPhase 41783
6Dermatologic AgentsPhase 4, Phase 14555
7Methyl 5-aminolevulinatePhase 4, Phase 152
8interferonsPhase 41930
9
Tacrolimusapproved, investigationalPhase 21023104987-11-3445643, 439492, 445647
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
8-DEETHYL-8-[but-3-enyl]-ascomycin
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
FR900506
 
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
Hecoria
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus Hydrate
Tacrolimus anhydrous
Tacrolimus hydrate
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
10Calcineurin InhibitorsPhase 21223
11Immunosuppressive AgentsPhase 210422

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisNot yet recruitingNCT02409732Phase 4
4Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's DiseaseCompletedNCT01233570Phase 2
5Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

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Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

33
Skin, Breast, Prostate, B cells, Liver, Brain, T cells

Animal Models for Cheilitis or affiliated genes

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MGI Mouse Phenotypes related to Cheilitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.1KRT16, MDM2, MMP9, MSH2, SUMO1, TP53
2MP:00053846.6CAST, KRT16, MDM2, MMP9, MSH2, SERPINB5

Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. (25683118)
2015
2
Recurrent cheilitis and lip oedema caused by (meth)acrylates present in ultraviolet-curable nail lacquer. (25682777)
2015
3
Clinicopathological profile and management of 161 cases of actinic cheilitis. (26375219)
2015
4
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. (26179312)
2015
5
Regulatory T cells in the actinic cheilitis. (25060152)
2014
6
How do I manage a patient with angular cheilitis? (23763743)
2013
7
Granulomatous cheilitis with granulomatous vulvitis: a rare association. (24177613)
2013
8
Comparative study on the microbiological features of angular cheilitis in HIV seropositive and HIV seronegative patients from South India. (24574650)
2013
9
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. (22714758)
2012
10
Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip. (22917688)
2012
11
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic cheilitis: a retrospective evaluation of 29 patients. (22370573)
2012
12
Crohn's disease revealed by a cheilitis granulomatosa with favorable evolution by perfusions of infliximab: report of a case and review of the literature. (21809492)
2011
13
Photoletter to the editor: Exfoliative cheilitis associated with titanium dental implants and mercury amalgam. (22408710)
2011
14
Organised angular cheilitis as the initial sign of Crohn's disease in two children. (21243320)
2011
15
Successful treatment of cheilitis granulomatosa with intralesional injection of triamcinolone. (19845820)
2010
16
Actinic cheilitis: evolution to squamous cell carcinoma after carbon dioxide laser vaporization. A study of 43 cases. (19418331)
2010
17
Actinic cheilitis: a treatment review. (20964646)
2010
18
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (19327639)
2009
19
Successful treatment of plasma cell cheilitis with topical calcineurin inhibitors. (19958456)
2009
20
Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases. (18489592)
2008
21
Oral Pathology Quiz #61. Case number 1. Actinic cheilitis. (19177961)
2008
22
Factitious cheilitis: a case report. (18226274)
2008
23
Cheilitis glandularis progressing to squamous cell carcinoma in an hiv-infected patient: case report. (18402312)
2007
24
Cheilitis granulomatosa of Melkersson-Rosenthal syndrome: treatment with intralesional corticosteroid injections. (14980194)
2004
25
Cheilitis glandularis: a case report. (15040488)
2004
26
Cheilitis glandularis: an unusual histopathologic presentation. (12627102)
2003
27
A yoga teacher with persistent cheilitis. (12800469)
2003
28
Eruptive cheilitis: a new adverse effect in reactive HIV-positive patients subjected to high activity antiretroviral therapy (HAART). Presentation of six clinical cases. (11488127)
2001
29
Granulomatous cheilitis and Crohn's disease. (11331931)
2001
30
Recurrent allergic contact dermatitis and cheilitis due to castor oil. (10703646)
2000
31
Angular cheilitis after tonsillectomy. (10472460)
1999
32
Acquired linear anetoderma following angular cheilitis. (9666860)
1998
33
Cheilitis granulomatosa treated with metronidazole. (8534947)
1995
34
Ulcerous granulomatous cheilitis with lymphatic invasion caused by Scopulariopsis brevicaulis infection. (7962740)
1994
35
Allergic contact cheilitis related to university studies. (8088159)
1994
36
Treatment of plasma cell cheilitis with griseofulvin. (8176022)
1994
37
Allergic contact cheilitis from a lipstick containing oxybenzone. (1451504)
1992
38
Case #5. Angular cheilitis. (1410625)
1992
39
Cheilitis glandularis. (9791264)
1992
40
Minocycline in granulomatous cheilitis: experience with 6 cases. (1446091)
1992
41
Cheilitis--part II. (2700683)
1989
42
Persistent swelling of the lower lip. Cheilitis granulomatosa. (3178252)
1988
43
Kveim test reactivity in Melkersson-Rosenthal syndrome (cheilitis granulomatosa). (2416173)
1985
44
Clinical observation on the treatment of exfoliative cheilitis with traditional Chinese medicine. (6570507)
1984
45
Chronic granulomatous cheilitis and its relationship to Crohn's disease. (6579479)
1983
46
Erosive cheilitis related to prochlorperazine maleate. (6958296)
1982
47
Solar cheilitis. (7338591)
1981
48
Cheilitis glandularis. (6930075)
1980
49
Staphylococcal cheilitis in the guinea-pig. (853732)
1977
50
Cheilitis as predominant symptom of pellagra. (14789438)
1950

Variations for Cheilitis

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Expression for genes affiliated with Cheilitis

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Search GEO for disease gene expression data for Cheilitis.

Pathways for genes affiliated with Cheilitis

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GO Terms for genes affiliated with Cheilitis

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Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00057309.2MDM2, SUMO1, TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:00063029.8MSH2, TP53
2intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.6MSH2, TP53
3intermediate filament cytoskeleton organizationGO:00451049.6KRT16, KRT6A
4nucleotide-excision repairGO:00062899.6SUMO1, TP53

Sources for Cheilitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet