Aliases & Classifications for Cheilitis

MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 14

Classifications:



External Ids:

Disease Ontology 12 DOID:1762
ICD10 33 K13.0
MeSH 42 D002613
NCIt 47 C79545
UMLS 69 C0007971

Summaries for Cheilitis

Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to angular cheilitis and cheilitis glandularis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and Chks in Checkpoint Regulation. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 72 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 angular cheilitis 12.3
2 cheilitis glandularis 12.2
3 actinic cheilitis 12.2
4 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.1
5 melkersson-rosenthal syndrome 11.7
6 actinic prurigo 11.1
7 orofacial granulomatosis 11.1
8 immunodeficiency 12 10.7
9 ichthyosis follicularis atrichia photophobia syndrome 10.7
10 rnase t2-deficient leukoencephalopathy 10.6 MDM2 TP53
11 rectum squamous cell carcinoma 10.6 MDM2 TP53
12 vulvar liposarcoma 10.6 MDM2 TP53
13 pylorus cancer 10.5 MALT1 TP53
14 rete testis adenoma 10.5 CDKN1A TP53
15 ureter urothelial papilloma 10.5 CDKN1A TP53
16 congenital granular cell tumor 10.5 CDKN1A TP53
17 breast epithelioid hemangioma 10.5 MDM2 TP53
18 endodermal sinus tumor 10.5 MDM2 TP53
19 secondary pulmonary hemosiderosis 10.5 MDM2 TP53
20 fallopian tube adenomatoid tumor 10.5 CDKN1A MDM2
21 ascaridiasis 10.5 MDM2 TP53
22 lymphopenia 10.5 MDM2 TP53
23 sparse hair ptosis mental retardation 10.4 MDM2 TP53
24 neurofibroma of the heart 10.4 KRT6A TP53
25 bladder squamous cell carcinoma 10.4 MDM2 TP53
26 biliary dyskinesia 10.3 MDM2 TP53
27 drug-induced hepatitis 10.3 MALT1 MDM2 TP53
28 enamel hypoplasia cataract hydrocephaly 10.3 MDM2 TP53
29 brain ischemia 10.3 MMP9 TP53
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 MMP9 MSH2
31 lung clear cell-sugar-tumor 10.2 CDKN1A MDM2 TP53
32 unilateral retinoblastoma 10.2 CDKN1A MDM2 TP53
33 familial episodic pain syndrome 10.2 MSH2 TP53
34 apocrine adenoma 10.2 MDM2 MSH2 TP53
35 pharynx cancer 10.2 CDKN1A MDM2 TP53
36 post-surgical hypoinsulinemia 10.2 CDKN1A MDM2 TP53
37 small cell sarcoma 10.2 CDKN1A MDM2 TP53
38 crohn's disease 10.2
39 nasopharyngeal carcinoma 10.2 CDKN1A MDM2 TP53
40 hand dermatosis 10.2 CDKN1A MSH2 TP53
41 ladd syndrome 10.2 CDKN1A MDM2 TP53
42 vulvar keratoacanthoma-like carcinoma 10.2 MSH2 TP53
43 squamous cell carcinoma 10.2
44 malignant giant cell tumor 10.1 MMP9 TP53
45 giant cell glioblastoma 10.1 CDKN1A MDM2 TP53
46 acquired hemangioma 10.1 ITGA3 MMP9
47 glomus tympanicum tumor 10.1 CDKN1A MDM2 TP53
48 c-p angle neurinoma 10.1 MDM2 TP53
49 dermatitis 10.0
50 phalanx chondroma 10.0 SERPINB5 TP53

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis

Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDKN1A MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 CAST CDKN1A ITGA3 MDM2 MMP9 MSH2
2 digestive/alimentary MP:0005381 9.95 CDKN1A ITGA3 MDM2 MMP9 MSH2 SUMO1
3 immune system MP:0005387 9.92 CAST CDKN1A ITGA3 MALT1 MDM2 MMP9
4 hematopoietic system MP:0005397 9.91 CDKN1A MALT1 MDM2 MMP9 MSH2 TP53
5 integument MP:0010771 9.73 CDKN1A ITGA3 MDM2 MMP9 MSH2 TP53
6 limbs/digits/tail MP:0005371 9.63 CAST CDKN1A ITGA3 MDM2 MMP9 TP53
7 mortality/aging MP:0010768 9.61 CAST CDKN1A ITGA3 MDM2 MMP9 MSH2
8 neoplasm MP:0002006 9.1 CDKN1A ITGA3 MDM2 MMP9 MSH2 TP53

Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 interferons Phase 4
4 Methyl 5-aminolevulinate Phase 4,Phase 1
5 Adjuvants, Immunologic Phase 4
6 Dermatologic Agents Phase 4,Phase 1
7 Photosensitizing Agents Phase 4,Phase 1
8 Interferon Inducers Phase 4
9
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
10 Immunosuppressive Agents Phase 2
11 Calcineurin Inhibitors Phase 2
12
Midazolam Approved, Illicit 59467-70-8 4192

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
6 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Not yet recruiting NCT03224715

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

id Genetic test Affiliating Genes
1 Cheilitis 29

Anatomical Context for Cheilitis

MalaCards organs/tissues related to Cheilitis:

39
Skin, Testes, Salivary Gland, T Cells, Tongue

Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 547)
id Title Authors Year
1
Allergic contact cheilitis in children and improvement with patch testing. ( 28050593 )
2017
2
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
3
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. ( 28794568 )
2017
4
Chronic cheilitis: Faecal calprotectin test a way to diagnose oral Crohn's disease. ( 28731524 )
2017
5
A surprising granulomatous cheilitis. ( 28712755 )
2017
6
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
7
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
8
Allergic contact cheilitis caused by olaflur in toothpaste. ( 27957754 )
2017
9
i>?Development i>?i>?ofi>? i>?i>?a facescan 3D facial reconstruction technology methodA for quantitative evaluationA of cheilitis granulomatosa. ( 28465526 )
2017
10
Granulomatous cheilitis mimicking angioedema. ( 28632806 )
2017
11
Miescher's cheilitis: Surgical management and long term outcome of an extremely severe case. ( 28192771 )
2017
12
Allergic contact cheilitis from anethole-containing toothpastes: a practical solution. ( 28214382 )
2017
13
Recurrent angular cheilitis after secukinumab injections. ( 28620989 )
2017
14
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
15
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
16
Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products. ( 27003364 )
2016
17
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
18
Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone. ( 27628958 )
2016
19
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
20
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
21
Granulomatous Cheilitis Associated With Crohn's Disease. ( 27125706 )
2016
22
Cheilitis glandularis: Case report with respect to immunohistochemical findings. ( 26816670 )
2016
23
Cheilitis granulomatosa. ( 27990408 )
2016
24
Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report. ( 27385520 )
2016
25
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
26
Clinical features, cytology and bacterial culture results in dogs with and without cheilitis and comparison of three sampling techniques. ( 27019393 )
2016
27
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
28
A case of allergic contact cheilitis caused by propolis and honey. ( 26899810 )
2016
29
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
30
Glycerin Borax Treatment of Exfoliative Cheilitis Induced by Sodium Lauryl Sulfate: a Case Report. ( 27789914 )
2016
31
Granulomatous cheilitis with gingival enlargement. ( 28474637 )
2016
32
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
33
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
34
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
35
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
36
Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. ( 27502182 )
2016
37
Resident Rounds: Part III - Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis. ( 26885796 )
2016
38
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
39
Cheilitis caused by to mint-containing toothpastes. ( 27620130 )
2016
40
Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease. ( 27017505 )
2016
41
Allergic contact cheilitis and hand dermatitis caused by a toothpaste. ( 26899811 )
2016
42
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. ( 26981737 )
2016
43
Clinically granulomatous cheilitis with plasma cells. ( 27057489 )
2016
44
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
45
Leishmaniasis recidiva cutis of the lips mimicking granulomatous cheilitis. ( 25814756 )
2015
46
Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy. ( 26568994 )
2015
47
Isotretinoin and Vitiligo: Can Chronic Cheilitis Cause Koebnerization? ( 25781892 )
2015
48
Herpetic cheilitis. ( 26354224 )
2015
49
Aspects of contact cheilitis: analysis of 38 cases. ( 25765961 )
2015
50
Lip Lesions: Lichen Planus vs. Solar Cheilitis. ( 26146909 )
2015

Variations for Cheilitis

Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 43)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 CDKN1A MALT1 MDM2 TP53
2
Show member pathways
12.54 CDKN1A MDM2 MSH2 TP53
3
Show member pathways
12.52 CDKN1A MDM2 SUMO1 TP53
4
Show member pathways
12.45 CDKN1A ITGA3 MSH2 TP53
5 12.4 CDKN1A ITGA3 MDM2 MMP9 MSH2 TP53
6 12.34 CDKN1A MDM2 MSH2 TP53
7 12.31 CDKN1A MDM2 MMP9 SERPINB5 TP53
8
Show member pathways
12.21 CDKN1A MDM2 SERPINB5 TP53
9
Show member pathways
12.18 CDKN1A MDM2 TP53
10 12.17 CDKN1A MDM2 TP53
11 12.16 CDKN1A MDM2 TP53
12 12.13 CDKN1A MDM2 MMP9 TP53
13
Show member pathways
12.12 CDKN1A MDM2 TP53
14
Show member pathways
12.08 CDKN1A ITGA3 MDM2 TP53
15 12.07 CDKN1A MDM2 MMP9 TP53
16 12.03 MDM2 MSH2 TP53
17 11.98 MMP9 SUMO1 TP53
18 11.98 CDKN1A MMP9 MSH2 TP53
19 11.95 CDKN1A SUMO1 TP53
20 11.88 CDKN1A MDM2 TP53
21 11.88 CDKN1A MMP9 TP53
22 11.86 CDKN1A MDM2 TP53
23 11.86 CDKN1A MDM2 SUMO1 TP53
24 11.83 CDKN1A MDM2 TP53
25 11.73 CDKN1A MDM2 SUMO1
26 11.71 CDKN1A ITGA3 TP53
27 11.71 CDKN1A MDM2 TP53
28
Show member pathways
11.7 CDKN1A MDM2 TP53
29 11.67 CDKN1A MDM2 MSH2 SERPINB5 TP53
30 11.65 CDKN1A MDM2 TP53
31 11.57 CDKN1A MDM2 MMP9 TP53
32 11.53 CDKN1A MDM2 MSH2 TP53
33 11.48 CDKN1A MDM2 MSH2 SERPINB5 TP53
34
Show member pathways
11.44 MDM2 SUMO1 TP53
35 11.31 CDKN1A MDM2 TP53
36 11.22 CDKN1A MDM2 MSH2 TP53
37 11.19 CDKN1A TP53
38 11.19 MDM2 TP53
39 11.17 MDM2 TP53
40 11.01 MDM2 TP53
41 10.7 CDKN1A TP53
42 10.65 MDM2 SUMO1
43
Show member pathways
10.27 CDKN1A MDM2 SUMO1 TP53

GO Terms for Cheilitis

Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.35 CDKN1A MALT1 MDM2 SUMO1 TP53
2 nuclear body GO:0016604 8.92 CDKN1A MDM2 SUMO1 TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.76 ITGA3 MMP9 SERPINB5
2 negative regulation of apoptotic process GO:0043066 9.72 CDKN1A MALT1 MDM2 MMP9 TP53
3 cell cycle arrest GO:0007050 9.7 CDKN1A MSH2 TP53
4 response to antibiotic GO:0046677 9.6 MDM2 TP53
5 cellular response to ionizing radiation GO:0071479 9.59 CDKN1A TP53
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.58 CDKN1A TP53
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.58 CDKN1A MDM2 TP53
8 cellular response to cadmium ion GO:0071276 9.57 MMP9 SUMO1
9 intrinsic apoptotic signaling pathway GO:0097193 9.56 CDKN1A TP53
10 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.55 MMP9 TP53
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.54 MDM2 MMP9
12 positive regulation of protein export from nucleus GO:0046827 9.49 MDM2 TP53
13 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 CDKN1A TP53
14 determination of adult lifespan GO:0008340 9.46 MSH2 TP53
15 replicative senescence GO:0090399 9.43 CDKN1A TP53
16 signal transduction by p53 class mediator GO:0072331 9.37 CDKN1A TP53
17 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
18 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
19 morphogenesis of an epithelium GO:0002009 9.21 SERPINB5
20 cellular response to gamma radiation GO:0071480 9.13 CDKN1A MDM2 TP53
21 response to X-ray GO:0010165 8.8 CDKN1A MSH2 TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.46 MDM2 MSH2 SUMO1 TP53
2 disordered domain specific binding GO:0097718 9.37 MDM2 TP53
3 SUMO transferase activity GO:0019789 9.26 MDM2 SUMO1
4 protease binding GO:0002020 9.13 ITGA3 MALT1 TP53
5 ubiquitin protein ligase binding GO:0031625 8.92 CDKN1A MDM2 SUMO1 TP53
6 protein binding GO:0005515 10.06 CAST CDKN1A ITGA3 KRT6A MALT1 MDM2

Sources for Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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