Aliases & Classifications for Cheilitis

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Aliases & Descriptions for Cheilitis:

Name: Cheilitis 11 27 13

Classifications:



External Ids:

Disease Ontology11 DOID:1762
ICD1030 K13.0
MeSH39 D002613
NCIt45 C79545

Summaries for Cheilitis

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Disease Ontology:11 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary: Cheilitis is related to angular cheilitis and cheilitis glandularis. An important gene associated with Cheilitis is TP53 (Tumor Protein P53), and among its related pathways are Oncogene Induced Senescence and Aurora A signaling. Affiliated tissues include skin, testes and salivary gland, and related mouse phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and craniofacial.

Wikipedia:71 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1angular cheilitis12.3
2cheilitis glandularis12.2
3actinic cheilitis12.2
4peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads12.1
5melkersson-rosenthal syndrome11.7
6orofacial granulomatosis11.1
7immunodeficiency 1210.8
8actinic prurigo polymorphic light eruption, hereditary10.8
9rommen mueller sybert syndrome10.3MDM2, TP53
10functionless pituitary adenoma10.3MDM2, TP53
11breast epithelioid hemangioma10.2CDKN1A, TP53
12inverted follicular keratosis10.2CDKN1A, TP53
13familial hypopituitarism10.2MSH2, TP53
14perineural angioma10.2CDKN1A, TP53
15endometrial squamous cell carcinoma10.2MDM2, TP53
16crohn's disease10.2
17squamous cell carcinoma10.2
18aorta atresia10.1MMP9, MSH2
19urinary tract obstruction10.1CDKN1A, MDM2
20cervical verrucous carcinoma10.1CDKN1A, MDM2, TP53
21extraocular retinoblastoma10.1CDKN1A, MDM2, TP53
22integumentary system benign neoplasm10.1CDKN1A, MDM2, TP53
23post-surgical hypoinsulinemia10.1CDKN1A, MDM2, TP53
24malignant spindle cell melanoma10.1CDKN1A, MSH2, TP53
25hidradenoma10.1MDM2, MSH2, TP53
26nasopharyngeal carcinoma10.1CDKN1A, MDM2, TP53
27thoracic outlet syndrome10.1CDKN1A, MDM2, TP53
28prostate cancer, hereditary, x-linked 110.1CDKN1A, MSH2, TP53
29brain meningioma10.1MMP9, TP53
30house allergic alveolitis10.1MDM2, TP53
31dysembryoplastic neuroepithelial tumor10.1CDKN1A, MSH2, TP53
32thanatophoric dysplasia, type ii10.1CDKN1A, MDM2, TP53
33coronary stenosis10.1MDM2, TP53
34glucose-6-phosphate translocase deficiency10.1CDKN1A, MDM2, TP53
35epithelioid malignant peripheral nerve sheath tumor10.1MMP9, SERPINB5
36progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 310.1MDM2, MMP9, TP53
37maxillary sinus cholesteatoma10.1CDKN1A, MMP9, TP53
38lattice corneal dystrophy10.1CDKN1A, MMP9, TP53
39lymphangitis10.1KRT6A, TMEM79, TP53
40dermatitis10.1
41cholesteatoma of middle ear10.0KRT6A, TMEM79
42mediastinum angiosarcoma10.0MDM2, SERPINB5, TP53
43hypotrichosis 810.0MDM2, MMP9, TP53
44glucosephosphate isomerase deficiency10.0MDM2, MMP9, TP53
45brain stem medulloblastoma10.0SERPINB5, TP53
46brain stem angioblastoma10.0MDM2, TP53
47muscular dystrophy-dystroglycanopathy , type b, 210.0CDKN1A, MDM2, MSH2, TP53
48spastic paraplegia 110.0MDM2, TNF, TP53
49papilledema9.9KRT6A, TNF
50in situ pulmonary adenocarcinoma9.9CDKN1A, MDM2, MMP9, TP53

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to cheilitis

Symptoms & Phenotypes for Cheilitis

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GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-39.4CDKN1A, MDM2, MSH2, SUMO1, TP53

MGI Mouse Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

41 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CDKN1A, MDM2, SUMO1, TNF, TP53
2MP:00053758.6CDKN1A, SERPINB5, TMEM79, TNF, TP53
3MP:00053718.4CAST, CDKN1A, MDM2, MMP9, TNF, TP53
4MP:00053818.1CDKN1A, MDM2, MMP9, MSH2, SUMO1, TNF
5MP:00107718.0CDKN1A, MDM2, MMP9, MSH2, TMEM79, TNF
6MP:00020067.7CDKN1A, MDM2, MMP9, MSH2, TNF, TP53
7MP:00053977.6CAST, CDKN1A, MDM2, MMP9, MSH2, TMEM79
8MP:00053877.6CAST, CDKN1A, MDM2, MMP9, MSH2, TMEM79
9MP:00053787.4CDKN1A, MDM2, MMP9, SERPINB5, SUMO1, TMEM79
10MP:00053847.3CAST, CDKN1A, MDM2, MMP9, MSH2, SERPINB5
11MP:00107687.1CAST, CDKN1A, MDM2, MMP9, MSH2, SERPINB5

Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Imiquimodapproved, investigationalPhase 414099011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
ZINC19632912
Zartra
Zyclara
imiquimod
2
Aminolevulinic acidapprovedPhase 4, Phase 1165106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid
3Interferon InducersPhase 4294
4Photosensitizing AgentsPhase 4, Phase 1492
5Adjuvants, ImmunologicPhase 42554
6Dermatologic AgentsPhase 4, Phase 15806
7Methyl 5-aminolevulinatePhase 4, Phase 160
8interferonsPhase 42175
9
Tacrolimusapproved, investigationalPhase 21102104987-11-3445643, 439492
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
Anhydrous tacrolimus
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
 
FR900506
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus anhydrous
Tacrolimus hydrate
Tacrolimus, anhydrous
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
10Calcineurin InhibitorsPhase 21622
11Immunosuppressive AgentsPhase 213086

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic TherapyCompletedNCT00849992Phase 4
2Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the LipCompletedNCT00868088Phase 4
3Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic CheilitisActive, not recruitingNCT02409732Phase 4
4Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's DiseaseCompletedNCT01233570Phase 2
5Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic CheilitisCompletedNCT02198469Phase 1

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

id Genetic test Affiliating Genes
1 Cheilitis27

Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

36
Skin, Testes, Salivary gland, T cells, Tongue

Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Cheilitis associated with Microcytic Hypochromic AnA (20914937)
mia.
2
Allergic contact cheilitis in children and improvement with patch testing. (28050593)
2017
3
Allergic contact cheilitis caused by olaflur in toothpaste. (27957754)
2017
4
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. (27778327)
2017
5
Cheilitis glandularis: Case report with respect to immunohistochemical findings. (26816670)
2016
6
Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. (27502182)
2016
7
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. (27241280)
2016
8
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. (27867726)
2016
9
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. (27579741)
2016
10
Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report. (27385520)
2016
11
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. (26981737)
2016
12
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. (27222882)
2016
13
Allergic contact cheilitis and hand dermatitis caused by a toothpaste. (26899811)
2016
14
Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone. (27628958)
2016
15
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. (27759902)
2016
16
Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease. (27017505)
2016
17
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. (27981067)
2016
18
A case of allergic contact cheilitis caused by propolis and honey. (26899810)
2016
19
Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products. (27003364)
2016
20
Glycerin Borax Treatment of Exfoliative Cheilitis Induced by Sodium Lauryl Sulfate: a Case Report. (27789914)
2016
21
Cheilitis granulomatosa. (27990408)
2016
22
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. (27420649)
2016
23
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. (27513668)
2016
24
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. (27029007)
2016
25
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. (26920763)
2016
26
Granulomatous Cheilitis Associated With Crohn's Disease. (27125706)
2016
27
Clinically granulomatous cheilitis with plasma cells. (27057489)
2016
28
Clinical features, cytology and bacterial culture results in dogs with and without cheilitis and comparison of three sampling techniques. (27019393)
2016
29
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. (27864997)
2016
30
Optical diagnosis of actinic cheilitis by infrared spectroscopy. (27491855)
2016
31
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. (27159259)
2016
32
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. (26842232)
2016
33
Resident Rounds: Part III - Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis. (26885796)
2016
34
Cheilitis caused by to mint-containing toothpastes. (27620130)
2016
35
Granulomatous cheilitis: a stiff upper lip. (26562278)
2015
36
Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. (25683118)
2015
37
Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature. (26164836)
2015
38
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. (26515234)
2015
39
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. (26677980)
2015
40
Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale. (26395167)
2015
41
Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy. (26568994)
2015
42
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. (26711374)
2015
43
Favorable response to composite treatment including infliximab in a case of granulomatous cheilitis with Crohn's disease. (25809090)
2015
44
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. (26264639)
2015
45
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. (25545762)
2015
46
Leishmaniasis recidiva cutis of the lips mimicking granulomatous cheilitis. (25814756)
2015
47
Contact allergy in cheilitis. (26547761)
2015
48
Granulomatous cheilitis with intralymphatic histiocytosis possibly associated with calcium deposition caused by chronic inflammation owing to dental metals and periodontitis. (25482731)
2015
49
Chronic cheilitis caused by acrylates used as an adhesive for an orthodontic brace. (25603970)
2015
50
Lip Lesions: Lichen Planus vs. Solar Cheilitis. (26146909)
2015

Variations for Cheilitis

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Expression for genes affiliated with Cheilitis

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Search GEO for disease gene expression data for Cheilitis.

Pathways for genes affiliated with Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathwaysScoreTop Affiliating Genes
19.9MDM2, TP53
29.9MDM2, TP53
39.9MDM2, TP53
49.8MDM2, SUMO1
5
Show member pathways
9.6CDKN1A, TP53
69.6MDM2, MSH2, TP53
79.6CDKN1A, TP53
89.6CDKN1A, TP53
9
Show member pathways
9.5MDM2, SUMO1, TP53
109.3CDKN1A, MDM2, TP53
119.3CDKN1A, MDM2, TP53
129.3CDKN1A, MDM2, TP53
139.3CDKN1A, MDM2, TP53
14
Show member pathways
9.3CDKN1A, MDM2, TP53
159.3CDKN1A, MDM2, TP53
169.3CDKN1A, MDM2, TP53
179.3CDKN1A, MDM2, TP53
189.3CDKN1A, MDM2, TP53
19
Show member pathways
9.3CDKN1A, MDM2, TP53
20
Show member pathways
9.3CDKN1A, MDM2, TP53
21
Show member pathways
9.3CDKN1A, MDM2, TP53
229.3CDKN1A, MDM2, TP53
23
Show member pathways
9.3CDKN1A, MDM2, TP53
24
Show member pathways
9.2CDKN1A, SUMO1, TP53
259.1CDKN1A, MDM2, SUMO1
26
Show member pathways
8.9CDKN1A, MDM2, MSH2, TP53
27
Show member pathways
8.9CDKN1A, MDM2, MSH2, TP53
288.9CDKN1A, MDM2, MSH2, TP53
298.9CDKN1A, MDM2, MSH2, TP53
308.9CDKN1A, MDM2, MSH2, TP53
318.9MMP9, TNF, TP53
32
Show member pathways
8.9CDKN1A, MDM2, SUMO1, TP53
338.9CDKN1A, MDM2, SUMO1, TP53
34
Show member pathways
8.9CDKN1A, MDM2, SUMO1, TP53
35
Show member pathways
8.8CDKN1A, MDM2, MMP9, TP53
368.8CDKN1A, MDM2, MMP9, TP53
378.7CDKN1A, TNF, TP53
38
Show member pathways
8.7CDKN1A, MDM2, SERPINB5, TP53
398.7CDKN1A, TNF, TP53
40
Show member pathways
8.5MMP9, SUMO1, TNF, TP53
418.5MMP9, SUMO1, TNF, TP53
428.5CDKN1A, MDM2, MMP9, MSH2, TP53
43
Show member pathways
8.4CDKN1A, MDM2, TNF, TP53
44
Show member pathways
8.4CDKN1A, MDM2, MSH2, SERPINB5, TP53
45
Show member pathways
8.4CDKN1A, MSH2, TNF, TP53
468.4CDKN1A, MDM2, MSH2, SERPINB5, TP53
478.3CDKN1A, MMP9, TNF, TP53
488.3CDKN1A, MDM2, MMP9, SERPINB5, TP53
498.0CDKN1A, MDM2, MMP9, TNF, TP53
508.0CDKN1A, MMP9, MSH2, TNF, TP53

GO Terms for genes affiliated with Cheilitis

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Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166048.9CDKN1A, MDM2, SUMO1, TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1cellular response to actinomycin DGO:007271710.6MDM2, TP53
2determination of adult lifespanGO:000834010.6MSH2, TP53
3positive regulation of protein export from nucleusGO:004682710.4MDM2, TP53
4cellular response to cadmium ionGO:007127610.3MMP9, SUMO1
5cellular response to ionizing radiationGO:007147910.3CDKN1A, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.3CDKN1A, TP53
7intrinsic apoptotic signaling pathwayGO:009719310.3CDKN1A, TP53
8positive regulation of release of cytochrome c from mitochondriaGO:009020010.2MMP9, TP53
9positive regulation of reactive oxygen species metabolic processGO:200037910.1CDKN1A, TP53
10cellular response to gamma radiationGO:007148010.0CDKN1A, MDM2, TP53
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.0CDKN1A, MDM2, TP53
12cell cycle arrestGO:000705010.0CDKN1A, MSH2, TP53
13intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0CDKN1A, MSH2, TP53
14replicative senescenceGO:009039910.0CDKN1A, TP53
15positive regulation of protein complex assemblyGO:00313349.8SUMO1, TNF
16positive regulation of programmed cell deathGO:00430689.6CDKN1A, TNF
17signal transduction by p53 class mediatorGO:00723319.6CDKN1A, TP53
18negative regulation of apoptotic processGO:00430669.5CDKN1A, MDM2, MMP9, TP53
19negative regulation of gene expressionGO:00106299.4CDKN1A, MDM2, TNF
20extracellular matrix organizationGO:00301989.4MMP9, SERPINB5, TNF
21response to X-rayGO:00101659.4CDKN1A, MSH2, TP53
22positive regulation of vascular smooth muscle cell proliferationGO:19047079.3MDM2, MMP9, TNF
23negative regulation of transcription, DNA-templatedGO:00458929.2MDM2, SUMO1, TNF, TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1disordered domain specific bindingGO:009771810.7MDM2, TP53
2SUMO transferase activityGO:001978910.4MDM2, SUMO1
3enzyme bindingGO:001989910.0MDM2, MSH2, SUMO1, TP53
4identical protein bindingGO:00428028.9MDM2, MMP9, TMEM79, TNF, TP53
5ubiquitin protein ligase bindingGO:00316258.9CDKN1A, MDM2, SUMO1, TP53
6protein bindingGO:00055156.1CAST, CDKN1A, KRT6A, MDM2, MMP9, MSH2

Sources for Cheilitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet