MCID: CHL056
MIFTS: 54

Cheilitis malady

Summaries for Cheilitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cheilitis (pronounced /kaɪˈlaɪtɪs/) is inflammation of the lips. This inflammation may include the... more...

MalaCards: Cheilitis, also known as cheilitis nos, is related to crohn's disease and squamous cell carcinoma. An important gene associated with Cheilitis is SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and p53 signaling pathway. The compounds estrogen and pdtc have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Cheilitis

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

cheilitis 8 60
cheilitis nos 8


External Ids:

Disease Ontology8 DOID:1762
NCIt39 C79545
MeSH34 D002613

Related Diseases for Cheilitis

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17GeneCards, 18GeneDecks
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Diseases related to Cheilitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease30.7TNF
2squamous cell carcinoma30.6MDM2, PTGS2, ERCC1, FGFR3, MSH2, TP53
3actinic keratosis30.0TP53
4periodontitis30.0MMP9
5leukemia30.0TNF, APEX1, MDM2, STAT3, CD1A, CDKN1A
6acute leukemia29.8MSH2
7neutropenia29.8STAT3
8kawasaki disease29.8MMP9
9tuberculosis29.8TNF, CD1A
10sarcoidosis29.8TNF
11melkersson-rosenthal syndrome10.6
12actinic cheilitis10.3
13dermatitis10.3
14contact dermatitis10.3
15stomatitis10.3
16cheilitis glandularis10.3
17vulvitis10.2
18allergic contact dermatitis10.2
19gingivitis10.2
20glossitis10.2
21chronic granulomatous disease10.0
22acne10.0
23angioedema10.0
24gingival disease10.0
25keratosis10.0
26lip cancer10.0
27systemic lupus erythematosus10.0PDCD1
28cervical intraepithelial neoplasia10.0MKI67
29dilated cardiomyopathy10.0CHKB
30testicular cancer10.0ERCC1
31deficiency anemia10.0CHKB
32leiomyoma10.0MKI67
33meningioma10.0MKI67
34polymyositis10.0CHKB
35letterer-siwe disease10.0CD1A
36leukoplakia10.0MKI67
37dermatomyositis10.0CHKB
38smooth muscle tumor10.0MKI67
39cholesteatoma10.0MMP9
40bronchiolitis10.0APEX1
41histiocytosis10.0CD1A
42bladder transitional cell papilloma10.0FGFR3
43pulmonary disease, chronic obstructive10.0MMP9
44skin disease10.0MMP9
45root resorption10.0CTNNBIP1
46pituitary adenoma10.0MKI67
47endometriosis10.0PTGS2
48hepatitis b10.0STAT3
49pulmonary fibrosis10.0MMP9
50sjogren's syndrome10.0BAX

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to cheilitis

Clinical Features for Cheilitis

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Drugs & Therapeutics for Cheilitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cheilitis

Search CenterWatch for Cheilitis

Genetic Tests for Cheilitis

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Anatomical Context for Cheilitis

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32MalaCards
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MalaCards organs/tissues related to Cheilitis:

32
Skin, Testes, Salivary gland, Tongue

Animal Models for Cheilitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cheilitis:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.5FGFR3, PDCD1
2MP:000539110.4FGFR3, PDCD1
3MP:000538010.2CTNNBIP1, SERPINB5
4MP:000537510.2ERCC1
5MP:00053769.8APEX1, CHKB, CD274, FGFR3
6MP:00036319.6CTNNBIP1, STAT3, CHKB, BAX, CDKN1A
7MP:00020069.4PDCD1, TNF, MDM2, CDKN1A, FGFR3, MMP9
8MP:00053909.4FGFR3, PDCD1, CTNNBIP1, STAT3, CHKB, BAX
9MP:00107719.3MDM2, STAT3, CDKN1A, MMP9, PTGS2, ERCC1
10MP:00053699.3PDCD1, APEX1, MDM2, CHKB, BAX, CDKN1A
11MP:00053799.2TNF, APEX1, STAT3, BAX, CDKN1A, TP53
12MP:00053829.1CTNNBIP1, MDM2, CDKN1A, FGFR3, TP53, TNF
13MP:00053859.0APEX1, MDM2, STAT3, CDKN1A, PTGS2, TP53
14MP:00053898.9APEX1, STAT3, BAX, CDKN1A, FGFR3, MMP9
15MP:00053708.8PDCD1, TNF, APEX1, MDM2, STAT3, CDKN1A
16MP:00053888.8CTNNBIP1, STAT3, BAX, CDKN1A, FGFR3, MMP9
17MP:00030128.8TP53, PTGS2, FGFR3, CDKN1A, CD274, MDM2
18MP:00053818.5TNF, CTNNBIP1, MDM2, STAT3, CDKN1A, FGFR3
19MP:00053788.2TNF, APEX1, MDM2, STAT3, BAX, CDKN1A
20MP:00053868.1BAX, CHKB, STAT3, MDM2, TNF, CD274
21MP:00053978.0PDCD1, TNF, MDM2, STAT3, BAX, CD274
22MP:00053877.8BAX, STAT3, MDM2, APEX1, TNF, PDCD1
23MP:00053847.4BAX, STAT3, MDM2, CTNNBIP1, APEX1, TNF
24MP:00107687.4BAX, STAT3, MDM2, CTNNBIP1, APEX1, TNF

Publications for Cheilitis

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50PubMed
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Articles related to Cheilitis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
How do I manage a patient with angular cheilitis? (23763743)
2013
2
Oral medicine case book 51: actinic cheilitis in a patient with oculocutaneous albinism. (23971281)
2013
3
Cheilitis glandularis: immunohistochemical expression of protein water channels (aquaporins) in minor labial salivary glands. (23294169)
2013
4
Topical photodynamic therapy may not be effective for actinic cheilitis despite repeated treatments. (24201136)
2013
5
Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). (24001384)
2013
6
Photodynamic therapy in actinic cheilitis: clinical and anatomopathological evaluation of 19 patients. (22714758)
2012
7
Angular cheilitis, part 1: local etiologies. (21838086)
2011
8
Actinic cheilitis among agricultural workers in Campinas, Brazil. (21485236)
2011
9
Cheilitis glandularis: two case reports of asian-Japanese men and literature review of Japanese cases. (21991474)
2011
10
Cheilitis granulomatosa. (22031641)
2011
11
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. (21085813)
2010
12
Contact cheilitis in a saxophonist. (20233554)
2010
13
Miescher cheilitis and myelomonocytic leukemia: a fortuitous association or a rare paraneoplastic syndrome? (20218814)
2010
14
Plasma-cell cheilitis: successful treatment with intralesional injections of corticosteroids. (18795938)
2009
15
Toothpaste allergy as a cause of cheilitis in Israeli patients. (19426615)
2009
16
Asymptomatic, edematous upper lip in a 39-year-old woman. Cheilitis granulomatosa (CG). (19153350)
2009
17
Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. (18674950)
2009
18
p53 and MDM2 protein expression in actinic cheilitis. (19082401)
2008
19
Granulomatous cheilitis successfully treated with roxithromycin. (18419685)
2008
20
Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis. (18234540)
2008
21
Recurrent lower lip swelling in a 62-year-old African American female. Cheilitis glandularis. (19022139)
2008
22
Granulomatous cheilitis in an HIV positive patient on HAART therapy. (18779107)
2008
23
A new modality in the treatment of actinic cheilitis using the Er:YAG laser. (17506137)
2007
24
Actinic cheilitis: histologic study of the entire vermilion and comparison with previous biopsy. (17381801)
2007
25
Allergic contact cheilitis induced by repeated contact with propolis-enriched honey. (15209822)
2004
26
Plasma cell cheilitis. (14678543)
2004
27
Erythematous swelling of the lip associated with SjAPgren's syndrome and mimicking cheilitis granulomatosa. (11280465)
2001
28
2 cases of allergic contact cheilitis from sodium lauryl sulfate in toothpaste. (10703642)
2000
29
Peracute gangrenous mastitis and cheilitis associated with enterotoxin-secreting Staphylococcus aureus in a goat. (7728725)
1995
30
Case report: cheilitis granulomatosa with periodontitis. (8586766)
1995
31
Granulomatous cheilitis in two children with sarcoidosis. (8408818)
1993
32
Association between cheilitis granulomatosa and Crohn's disease. (8496438)
1993
33
Minocycline in granulomatous cheilitis: experience with 6 cases. (1446091)
1992
34
Carbon dioxide laser treatment of actinic cheilitis. (1536077)
1992
35
Circumoral dermatitis and cheilitis caused by tartar control dentifrices. (2164535)
1990
36
Cheilitis--part II. (2700683)
1989
37
Recurrence of angular cheilitis. (3166200)
1988
38
Treatment of angular cheilitis. The significance of microbial analysis, antimicrobial treatment, and interfering factors. (3063051)
1988
39
Prevention of the "prickling sensation" following surgery for actinic cheilitis. (3385051)
1988
40
Microscopically proven cure of actinic cheilitis by CO2 laser. (3431329)
1987
41
Angular cheilitis: a clinical and microbial study. (3088236)
1986
42
Cheilitis antedating Crohn's disease: case report and literature update of oral lesions. (6481118)
1984
43
Phototoxic and contact toxic reactions of the exocarp of sweet oranges: a common cause of cheilitis? (6861482)
1983
44
Cheilitis glandularis. (6954441)
1982
45
Cheilitis glandularis. (6930075)
1980
46
Cheilitis glandularis treated by injection of intralesional triamcinolone. (1010613)
1976
47
Plasma cell cheilitis. (4422015)
1974
48
Acquired cheilitis glandularis simplex. Case report. (4689679)
1973
49
Cheilitis glandularis, heterotopic salivary glands and squamous cell carcinoma of the lip. (13935463)
1962
50
Cheilitis glandularis apostematosa. (14370767)
1955

Genetic Variations for Cheilitis

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Expression for genes affiliated with Cheilitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for genes affiliated with Cheilitis

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Sources:
49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 51QIAGEN, 12EMD Millipore, 55SinoBiological, 4Cell Signaling Technology, 52R&D Systems, 53Reactome
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Pathways related to Cheilitis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TP53, MSH2
2
Hide members
9.9MDM2, BAX, SERPINB5
3
Hide members
9.9FGFR3, BAX, MDM2
49.9MSH2, STAT3, APEX1
59.9APEX1, MDM2, TP53
69.8CDKN1A, TP53, MDM2
79.8TP53, CDKN1A, MDM2
89.8MMP9, PTGS2, CDKN1A
9
Hide members
9.8STAT3, TP53, FGFR3
109.8TP53, BAX, MMP9
119.8TP53, STAT3, MDM2
129.8TP53, BAX, CDKN1A
139.8CDKN1A, BAX, TNF
149.8BAX, TNF, STAT3
15
Hide members
9.7BAX, TNF, TP53
169.7MMP9, PTGS2, SERPINB5, FGFR3
179.6SERPINB5, CDKN1A, TP53, BAX
18
Transcription P53 signaling pathway
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9.6MDM2, TP53, CDKN1A, APEX1
199.6MDM2, CDKN1A, FGFR3, TP53
20
Hide members
9.6CDKN1A, FGFR3, TP53, MDM2
219.6TP53, MSH2, BAX, MDM2
229.6MDM2, TP53, MMP9, CDKN1A
239.6CDKN1A, TP53, BAX, MDM2
24
Hide members
9.6MDM2, CDKN1A, TP53, BAX
259.6MDM2, CDKN1A, TP53, BAX
26
Hide members
9.6CDKN1A, TP53, BAX, MDM2
279.6CDKN1A, MDM2, STAT3, TP53
28
Hide members
9.6STAT3, TP53, MDM2, CDKN1A
29
Hide members
9.6TP53, MDM2, CDKN1A, STAT3
309.6TP53, APEX1, TNF, MMP9
31
Hide members
9.5STAT3, BAX, TNF, CDKN1A
32
Hide members
9.5STAT3, PTGS2, TP53, BAX
33
Hide members
9.5MDM2, CDKN1A, MSH2, APEX1, ERCC1
34
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.5TNF, BAX, CDKN1A, TP53
359.5TNF, CDKN1A, STAT3, TP53
36
Hide members
9.5MMP9, CDKN1A, STAT3, MDM2, FGFR3
37
Hide members
9.4STAT3, BAX, TP53, MDM2, MSH2
389.4MDM2, STAT3, BAX, TP53, CDKN1A
399.3MSH2, TP53, BAX, MDM2, SERPINB5, CDKN1A
40
Hide members
9.2MKI67, MDM2, APEX1, CDKN1A, MSH2, ERCC1
41
Hide members
9.2STAT3, MSH2, BAX, TP53, CDKN1A, MDM2
42
Hide members
9.2TNF, MDM2, BAX, FGFR3, MMP9, TP53
439.1TNF, TP53, MMP9, CDKN1A, STAT3, MDM2
449.1TP53, MDM2, CDKN1A, TNF, PTGS2, BAX
45
Hide members
9.1TNF, CDKN1A, STAT3, BAX, TP53, MMP9
46
Hide members
8.9BAX, FGFR3, MDM2, STAT3, TP53, CDKN1A
47
Hide members
8.9CDKN1A, BAX, TP53, PTGS2, FGFR3, STAT3
488.8MDM2, TP53, STAT3, MMP9, CDKN1A, FGFR3
49
Hide members
8.7TNF, MDM2, BAX, TP53, STAT3, PTGS2
508.6BAX, MDM2, STAT3, CDKN1A, FGFR3, MMP9

Compounds for genes affiliated with Cheilitis

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Cheilitis according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHKB
2pdtc4410.6MMP9, SERPINB5
3h2o24410.2CHKB, CDKN1A, APEX1
4etoposide44 49 59 1113.1ERCC1, BAX, MDM2
510-hydroxycamptothecin4410.0CDKN1A, MDM2, BAX, TP53
6tamoxifen44 49 28 1113.0MKI67, CDKN1A, SERPINB5, CHKB
7vincristine44 49 1112.0BAX, MKI67, ERCC1
8noxa449.9TP53, MDM2, BAX, CDKN1A
9dexamethasone44 49 28 1112.9STAT3, PTGS2, MMP9, MDM2
10flavopiridol44 1110.7TP53, CDKN1A, BAX, STAT3, MDM2
11triptolide449.7BAX, TNF, TP53, PTGS2
12sulindac44 1110.7PTGS2, STAT3, CDKN1A, BAX, TP53
13ns 39844 5910.7PTGS2, CDKN1A, TNF, MMP9
14bortezomib44 1110.7CDKN1A, TP53, STAT3, BAX, FGFR3
15gefitinib44 49 1111.7CDKN1A, STAT3, MMP9, PTGS2, MDM2
16parthenolide44 210.7TNF, STAT3, MMP9, PTGS2, TP53
17melphalan44 1110.7ERCC1, TP53, TNF, FGFR3, CHKB, MDM2
18indole-3-carbinol449.6TP53, CDKN1A, STAT3, BAX
19gemcitabine44 49 1111.6TP53, ERCC1, PTGS2, BAX, APEX1, CDKN1A
20celecoxib44 59 28 49 11 2414.6MMP9, CDKN1A, BAX, MKI67, PTGS2
21docetaxel44 49 59 1112.6CDKN1A, MDM2, TP53, STAT3, BAX, ERCC1
22irinotecan44 49 1111.6MDM2, BAX, MKI67, TP53, CDKN1A, ERCC1
23paclitaxel44 49 1111.6STAT3, MDM2, BAX, CDKN1A, ERCC1, TP53
24ciglitazone44 2810.5STAT3, BAX, CDKN1A, TNF, PTGS2, MMP9
25arsenite44 2410.5BAX, TP53, MMP9, MDM2, STAT3, CDKN1A
26mg 13244 5910.5TNF, STAT3, BAX, CDKN1A, TP53, MDM2
27methotrexate44 49 1111.4MKI67, CHKB, MDM2, TNF, MMP9, ERCC1
28camptothecin44 59 1111.4MDM2, BAX, CDKN1A, APEX1, TP53
29dutp449.4TP53, MKI67, BAX, MDM2
30lactacystin449.4ERCC1, MMP9, TP53, CDKN1A, MDM2, STAT3
31adpribose449.4APEX1, BAX, CDKN1A, TNF, TP53, STAT3
32thymidylate449.3TP53, ERCC1, MSH2, CDKN1A, MKI67, BAX
33troglitazone44 28 59 1112.3TNF, BAX, CDKN1A, MMP9, PTGS2
34sulforaphane449.3PTGS2, CDKN1A, BAX, APEX1
35sp 60012544 5910.3TP53, CDKN1A, BAX, STAT3, MDM2, TNF
36serine449.2MMP9, MSH2, STAT3, MKI67, APEX1, TNF
37sb 20358044 5910.2BAX, TNF, STAT3, CDKN1A, MMP9, PTGS2
38genistein44 28 59 2 11 2414.2TNF, STAT3, CDKN1A, MDM2, PTGS2, BAX
39pd 98,059449.2MDM2, STAT3, CDKN1A, MMP9, ERCC1, BAX
405fluorouracil449.1TP53, ERCC1, MSH2, CDKN1A, MKI67, BAX
41curcumin449.1STAT3, BAX, CDKN1A, TP53, MDM2, PTGS2
42ly294002449.1TP53, STAT3, TNF, PTGS2, MMP9, CDKN1A
43actinomycin d449.1CDKN1A, TP53, TNF, PTGS2, MDM2, STAT3
44thymidine44 2410.0MKI67, CHKB, TNF, ERCC1, TP53, MDM2
45n acetylcysteine449.0BAX, CHKB, CDKN1A, PTGS2, TP53, APEX1
46doxorubicin44 49 1110.9MSH2, FGFR3, ERCC1, MKI67, BAX, TP53
47nitric oxide44 11 2410.8TNF, CHKB, MDM2, MKI67, CD274, PTGS2
48cisplatin44 49 59 1111.6MDM2, STAT3, BAX, MKI67, CDKN1A, MSH2
49paraffin448.4MKI67, MDM2, STAT3, CHKB, BAX, CDKN1A
50vegf448.1TP53, TNF, SERPINB5, ERCC1, PTGS2, MMP9

GO Terms for genes affiliated with Cheilitis

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Sources:
16Gene Ontology
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Cellular components related to Cheilitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.2MDM2, STAT3, CDKN1A, ERCC1, TP53, APEX1
2cytoplasmGO:0057377.7TP53, APEX1, CTNNBIP1, MDM2, STAT3, CHKB

Biological processes related to Cheilitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generationGO:03162210.2PTGS2, TNF
2transformed cell apoptotic processGO:00692710.2BAX, TNF
3germ cell developmentGO:00728110.2ERCC1, MSH2, BAX
4positive regulation of programmed cell deathGO:04306810.2CDKN1A, TNF
5response to X-rayGO:01016510.2MSH2, ERCC1, TP53
6double-strand break repairGO:00630210.1MSH2, ERCC1, TP53
7mitotic cell cycle arrestGO:07185010.1CDKN1A, TP53
8cellular response to UVGO:03464410.1BAX, PTGS2, TP53
9response to salt stressGO:00965110.1TP53, BAX, TNF
10positive regulation of protein oligomerizationGO:03246110.1BAX, TP53
11intrinsic apoptotic signaling pathwayGO:09719310.1TP53, CDKN1A, BAX
12positive regulation of neuron apoptotic processGO:04352510.0TP53, BAX, TNF
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.0MDM2, CDKN1A, TP53
14DNA recombinationGO:0063109.9ERCC1, KIN, APEX1
15cellular response to hypoxiaGO:0714569.8MDM2, PTGS2, TP53
16response to DNA damage stimulusGO:0069749.7BAX, CDKN1A, KIN, TP53
17determination of adult lifespanGO:0083409.7MSH2, TP53
18negative regulation of apoptotic processGO:0430669.6MDM2, CDKN1A, FGFR3, ERCC1, TP53
19DNA repairGO:0062819.6ERCC1, MSH2, KIN, APEX1
20modulation by virus of host morphology or physiologyGO:0190489.6MDM2, STAT3, BAX, KIN, TP53
21neurotrophin TRK receptor signaling pathwayGO:0480119.6FGFR3, CDKN1A, STAT3, MDM2
22response to drugGO:0424939.5TNF, APEX1, MDM2, STAT3, CDKN1A, PTGS2
23positive regulation of apoptotic processGO:0430659.5TP53, PTGS2, MMP9, FGFR3, BAX, TNF
24negative regulation of transcription from RNA polymerase II promoterGO:0001229.4TNF, CTNNBIP1, MDM2, STAT3, FGFR3, TP53

Molecular functions related to Cheilitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.8APEX1, ERCC1, TP53
2enzyme bindingGO:0198999.6TP53, PTGS2, MSH2, MDM2
3identical protein bindingGO:0428029.1TNF, MDM2, BAX, MMP9, TP53
4protein bindingGO:0055156.8TP53, PDCD1, TNF, APEX1, CTNNBIP1, MDM2

Products for genes affiliated with Cheilitis

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  • Antibodies
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Sources for Cheilitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet