Aliases & Classifications for Cheilitis

MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 28 14

Classifications:



External Ids:

Disease Ontology 12 DOID:1762
ICD10 32 K13.0
MeSH 41 D002613
NCIt 46 C79545
UMLS 69 C0007971

Summaries for Cheilitis

Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to actinic cheilitis and oral squamous cell carcinoma. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Endometrial cancer and Downstream signaling events of B Cell Receptor (BCR). The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 33.3 CDKN1A MDM2 MSH2 TP53
2 oral squamous cell carcinoma 29.0 CDKN1A MDM2 MMP9 TP53
3 lip cancer 28.9 CDKN1A MDM2 MSH2 SUMO1 TP53
4 angular cheilitis 12.4
5 cheilitis glandularis 12.4
6 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.2
7 melkersson-rosenthal syndrome 11.8
8 actinic prurigo 11.2
9 orofacial granulomatosis 11.2
10 immunodeficiency 12 10.9
11 ichthyosis follicularis atrichia photophobia syndrome 10.9
12 ring chromosome 7 10.4 MDM2 TP53
13 sclerosing liposarcoma 10.4 MDM2 TP53
14 anal squamous cell carcinoma 10.4 MDM2 TP53
15 periosteal osteogenic sarcoma 10.3 MDM2 TP53
16 invasive bladder transitional cell carcinoma 10.3 CDKN1A TP53
17 dedifferentiated liposarcoma 10.3 MDM2 TP53
18 bladder transitional cell papilloma 10.3 CDKN1A TP53
19 atypical follicular adenoma 10.3 CDKN1A TP53
20 gliomatosis cerebri 10.3 MDM2 TP53
21 soft tissue sarcoma 10.3 MDM2 TP53
22 crohn's disease 10.3
23 nodular ganglioneuroblastoma 10.3 CDKN1A MDM2
24 suppressor of tumorigenicity 3 10.3 CDKN1A TP53
25 small cell sarcoma 10.3 MDM2 TP53
26 squamous cell carcinoma 10.3
27 myxosarcoma 10.3 MDM2 TP53
28 embryonal sarcoma 10.2 MDM2 TP53
29 cellular schwannoma 10.2 MDM2 TP53
30 cerebral primitive neuroectodermal tumor 10.2 MSH2 TP53
31 diffuse large b-cell lymphoma 10.2 MALT1 MDM2 TP53
32 brain glioblastoma multiforme 10.2 MMP9 TP53
33 familial colorectal cancer 10.2 MSH2 TP53
34 dermatitis 10.1
35 anal fistula 10.1 MMP9 MSH2
36 malignant mesenchymoma 10.1 CDKN1A MDM2 TP53
37 retinal cancer 10.1 CDKN1A MDM2 TP53
38 sensory system cancer 10.1 CDKN1A MDM2 TP53
39 ocular cancer 10.1 CDKN1A MDM2 TP53
40 nervous system cancer 10.1 CDKN1A MDM2 TP53
41 keratoacanthoma 10.1 CDKN1A MSH2 TP53
42 li-fraumeni syndrome 10.1 CDKN1A MDM2 TP53
43 pigmented villonodular synovitis 10.1 MMP9 TP53
44 testicular germ cell tumor 10.1 CDKN1A MSH2 TP53
45 villous adenocarcinoma 10.0 ITGA3 MMP9
46 stomatitis 10.0
47 bone squamous cell carcinoma 10.0 SERPINB5 TP53
48 contact dermatitis 10.0
49 gingivitis 10.0
50 vulvitis 10.0

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis

Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDKN1A MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 MDM2 TP53 CAST MMP9 CDKN1A MSH2
2 hematopoietic system MP:0005397 9.97 MDM2 CAST MMP9 CDKN1A MSH2 SERPINB5
3 digestive/alimentary MP:0005381 9.95 TP53 MMP9 CDKN1A MSH2 ITGA3 SUMO1
4 immune system MP:0005387 9.92 MDM2 CAST MMP9 CDKN1A MSH2 ITGA3
5 integument MP:0010771 9.8 MDM2 CAST MMP9 CDKN1A MSH2 ITGA3
6 mortality/aging MP:0010768 9.65 MDM2 TP53 CAST MMP9 CDKN1A MSH2
7 limbs/digits/tail MP:0005371 9.63 MDM2 CAST MMP9 CDKN1A ITGA3 TP53
8 neoplasm MP:0002006 9.1 MDM2 MMP9 CDKN1A MSH2 ITGA3 TP53

Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Interferon Inducers Phase 4
5 interferons Phase 4
6 Methyl 5-aminolevulinate Phase 4,Phase 1
7 Dermatologic Agents Phase 4,Phase 1
8 Photosensitizing Agents Phase 4,Phase 1
9
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
10 Calcineurin Inhibitors Phase 2
11 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
5 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
6 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
7 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 28

Anatomical Context for Cheilitis

MalaCards organs/tissues related to Cheilitis:

38
Skin, Testes, Salivary Gland, T Cells, Tongue

Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 557)
# Title Authors Year
1
A favorable response to omalizumab in a patient with cheilitis granulomatosa. ( 29426753 )
2018
2
Granulomatous cheilitis mimicking angioedema. ( 28632806 )
2017
3
Allergic contact cheilitis in children and improvement with patch testing. ( 28050593 )
2017
4
Cheilitis ( 29262127 )
2017
5
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
6
Miescher's cheilitis: Surgical management and long term outcome of an extremely severe case. ( 28192771 )
2017
7
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. ( 28794568 )
2017
8
Successful treatment of childhood cheilitis granulomatosa with infliximab. ( 28985456 )
2017
9
Cheilitis Granulomatosa (Miescher Melkersson Rosenthal Syndrome) ( 29261927 )
2017
10
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
11
Coexistence of Cheilitis Glandularis and Lichen Planus: Remarkable Response to Anti-inflammatory Treatments. ( 28979035 )
2017
12
Angular cheilitis: A clinical and microbial study. ( 29256466 )
2017
13
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
14
Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases. ( 28966508 )
2017
15
Erfolgreiche Behandlung einer Cheilitis granulomatosa mit Infliximab bei Kindern. ( 29228481 )
2017
16
A surprising granulomatous cheilitis. ( 28712755 )
2017
17
Chronic cheilitis: Faecal calprotectin test a way to diagnose oral Crohn's disease. ( 28731524 )
2017
18
Allergic contact cheilitis caused by olaflur in toothpaste. ( 27957754 )
2017
19
Recurrent angular cheilitis after secukinumab injections. ( 28620989 )
2017
20
i>?Development i>?i>?ofi>? i>?i>?a facescan 3D facial reconstruction technology methodA for quantitative evaluationA of cheilitis granulomatosa. ( 28465526 )
2017
21
Allergic Contact Cheilitis From a Variety of Lip Balm Ingredients. ( 29039219 )
2017
22
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
23
Allergic contact cheilitis from anethole-containing toothpastes: a practical solution. ( 28214382 )
2017
24
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
25
Granulomatous Cheilitis Associated With Crohn's Disease. ( 27125706 )
2016
26
Clinically granulomatous cheilitis with plasma cells. ( 27057489 )
2016
27
Resident Rounds: Part III - Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis. ( 26885796 )
2016
28
Cheilitis caused by to mint-containing toothpastes. ( 27620130 )
2016
29
Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. ( 27502182 )
2016
30
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
31
A case of allergic contact cheilitis caused by propolis and honey. ( 26899810 )
2016
32
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
33
Cheilitis glandularis: Case report with respect to immunohistochemical findings. ( 26816670 )
2016
34
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
35
Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products. ( 27003364 )
2016
36
Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report. ( 27385520 )
2016
37
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
38
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
39
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
40
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
41
Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone. ( 27628958 )
2016
42
Granulomatous cheilitis with gingival enlargement. ( 28474637 )
2016
43
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
44
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
45
Cheilitis granulomatosa. ( 27990408 )
2016
46
Clinical features, cytology and bacterial culture results in dogs with and without cheilitis and comparison of three sampling techniques. ( 27019393 )
2016
47
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
48
Allergic contact cheilitis and hand dermatitis caused by a toothpaste. ( 26899811 )
2016
49
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
50
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. ( 26981737 )
2016

Variations for Cheilitis

Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CDKN1A MDM2 MMP9 MSH2 TP53
2
Show member pathways
12.61 CDKN1A MALT1 MDM2 TP53
3 12.6 CDKN1A ITGA3 MDM2 MMP9 MSH2 TP53
4
Show member pathways
12.56 CDKN1A MDM2 MSH2 TP53
5
Show member pathways
12.53 CDKN1A MDM2 SUMO1 TP53
6
Show member pathways
12.46 CDKN1A ITGA3 MSH2 TP53
7
Show member pathways
12.44 CDKN1A MDM2 MMP9 TP53
8 12.35 CDKN1A MDM2 MSH2 TP53
9 12.31 CDKN1A MDM2 MMP9 SERPINB5 TP53
10
Show member pathways
12.21 CDKN1A MDM2 SERPINB5 TP53
11 12.18 CDKN1A MDM2 TP53
12 12.17 CDKN1A MDM2 TP53
13
Show member pathways
12.14 CDKN1A MDM2 TP53
14 12.13 CDKN1A MDM2 MMP9 TP53
15 12.08 CDKN1A MDM2 MMP9 TP53
16 12.06 CDKN1A MDM2 TP53
17
Show member pathways
12.06 CDKN1A ITGA3 MDM2 TP53
18 12.04 MDM2 MSH2 TP53
19
Show member pathways
12.04 CDKN1A MDM2 TP53
20 11.99 MMP9 SUMO1 TP53
21 11.98 CDKN1A MMP9 MSH2 TP53
22 11.97 CDKN1A SUMO1 TP53
23 11.9 CDKN1A MDM2 TP53
24 11.89 CDKN1A MMP9 TP53
25 11.87 CDKN1A MDM2 TP53
26 11.86 CDKN1A MDM2 SUMO1 TP53
27 11.84 CDKN1A MDM2 TP53
28 11.76 CDKN1A ITGA3 TP53
29 11.74 CDKN1A MDM2 SUMO1
30 11.72 CDKN1A MDM2 TP53
31
Show member pathways
11.71 CDKN1A MDM2 TP53
32 11.67 CDKN1A MDM2 MSH2 SERPINB5 TP53
33 11.66 CDKN1A MDM2 TP53
34 11.53 CDKN1A MDM2 MMP9 TP53
35 11.49 CDKN1A MDM2 MSH2 TP53
36 11.47 CDKN1A MDM2 MSH2 SERPINB5 TP53
37
Show member pathways
11.44 MDM2 SUMO1 TP53
38 11.31 CDKN1A MDM2 TP53
39 11.22 CDKN1A MDM2 MSH2 TP53
40 11.21 CDKN1A TP53
41 11.2 MDM2 TP53
42 11.18 MDM2 TP53
43 11.02 MDM2 TP53
44 10.72 CDKN1A TP53
45 10.66 MDM2 SUMO1
46
Show member pathways
10.46 CDKN1A TP53
47
Show member pathways
10.27 CDKN1A MDM2 SUMO1 TP53

GO Terms for Cheilitis

Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.35 CDKN1A MALT1 MDM2 SUMO1 TP53
2 nuclear body GO:0016604 8.92 CDKN1A MDM2 SUMO1 TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.79 ITGA3 MMP9 SERPINB5
2 negative regulation of apoptotic process GO:0043066 9.77 CDKN1A MALT1 MDM2 MMP9 TP53
3 response to drug GO:0042493 9.76 CDKN1A ITGA3 MDM2 TP53
4 cell cycle arrest GO:0007050 9.73 CDKN1A MSH2 TP53
5 cellular response to reactive oxygen species GO:0034614 9.63 MMP9 TP53
6 cellular response to ionizing radiation GO:0071479 9.62 CDKN1A TP53
7 response to antibiotic GO:0046677 9.61 MDM2 TP53
8 intrinsic apoptotic signaling pathway GO:0097193 9.61 CDKN1A TP53
9 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.61 CDKN1A MDM2 TP53
10 cellular response to cadmium ion GO:0071276 9.6 MMP9 SUMO1
11 positive regulation of reactive oxygen species metabolic process GO:2000379 9.59 CDKN1A TP53
12 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.58 MMP9 TP53
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 MDM2 MMP9
14 morphogenesis of an epithelium GO:0002009 9.57 KRT6A SERPINB5
15 response to hyperoxia GO:0055093 9.55 CDKN1A TP53
16 positive regulation of protein export from nucleus GO:0046827 9.54 MDM2 TP53
17 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.52 CDKN1A TP53
18 determination of adult lifespan GO:0008340 9.51 MSH2 TP53
19 cellular response to heat GO:0034605 9.5 CDKN1A SUMO1 TP53
20 replicative senescence GO:0090399 9.49 CDKN1A TP53
21 response to UV-B GO:0010224 9.48 MSH2 TP53
22 signal transduction by p53 class mediator GO:0072331 9.4 CDKN1A TP53
23 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
24 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
25 cellular response to gamma radiation GO:0071480 9.13 CDKN1A MDM2 TP53
26 response to X-ray GO:0010165 8.8 CDKN1A MSH2 TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.54 MSH2 SUMO1 TP53
2 enzyme binding GO:0019899 9.46 MDM2 MSH2 SUMO1 TP53
3 disordered domain specific binding GO:0097718 9.4 MDM2 TP53
4 SUMO transferase activity GO:0019789 9.26 MDM2 SUMO1
5 protease binding GO:0002020 9.13 ITGA3 MALT1 TP53
6 ubiquitin protein ligase binding GO:0031625 8.92 CDKN1A MDM2 SUMO1 TP53
7 protein binding GO:0005515 10.06 CAST CDKN1A ITGA3 KRT6A MALT1 MDM2

Sources for Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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