MCID: CHC001
MIFTS: 60

Chickenpox malady

Infectious diseases, Skin diseases categories
Download this MalaCard

Summaries for Chickenpox

About this section
Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Chickenpox is an infection caused by the varicella-zoster virus. most cases are in children under age 15, but older children and adults can get it. it spreads very easily from one person to another. the classic symptom of chickenpox is an uncomfortable, itchy rash. the rash turns into fluid-filled blisters and eventually into scabs. it usually shows up on the face, chest, and back and then spreads to the rest of the body. other symptoms include fever headache tiredness loss of appetite chickenpox is usually mild and lasts 5 to 10 days. calamine lotions and oatmeal baths can help with itching. acetaminophen can treat the fever. do not use aspirin for chickenpox; that combination can cause reye syndrome. chickenpox can sometimes cause serious problems. adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. they may need to take antiviral medicines. once you catch chickenpox, the virus usually stays in your body. you probably will not get chickenpox again, but the virus can cause shingles in adults. a chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. centers for disease control and prevention

MalaCards: Chickenpox, also known as varicella, is related to herpes zoster and pneumonia, and has symptoms including blisters, sore throat and headache. An important gene associated with Chickenpox is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways is Primary immunodeficiency. The drugs acyclovir and acyclovir sodium and the compounds s 100 and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and tonsil, and related mouse phenotypes are no phenotypic analysis and normal.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. the infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

CDC:4 Chickenpox is a very contagious disease caused by the varicella-zoster virus (VZV). It causes a blister-like rash, itching, tiredness, and fever. The rash appears first on the trunk and face and can spread over the entire body causing between 250 and 500 itchy blisters…

Wikipedia:65 Chickenpox is a highly contagious disease caused by primary infection with varicella zoster virus (VZV).... more...

Aliases & Classifications for Chickenpox

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Chickenpox

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chickenpox via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 353)
idRelated DiseaseScoreTop Affiliating Genes
1herpes zoster30.9DNAJC28, CD4
2pneumonia30.7MUC1, CD4, CD79A
3purpura30.6CD79A
4meningoencephalitis30.5CD4, CD79A
5measles30.5CD79A, CD4
6fasciitis30.4ACTC1
7thrombophlebitis30.3APOH
8mumps30.3CD79A, CD4
9protein c deficiency30.3APOH, PROS1
10tetanus30.2CD79A, CD4
11toxoplasmosis30.2CD4, CD79A
12vasculitis30.1CD79A, PROS1, APOH
13protein s deficiency30.1APOH, PROS1
14neuropathy30.0CD79A, CD4
15hepatitis b30.0GPT, CD4, CD79A
16gastritis29.9CD79A, CD4
17pulmonary embolism29.9PROS1, APOH
18venous thrombosis29.9APOH, PROS1
19cryptosporidiosis29.8CD4, CD79A
20meningitis29.8CD4, CD79A
21diphtheria29.8CD79A, CD4
22thrombocytopenia29.8CD79A, CD4, APOH, GPT
23ipex syndrome29.8CD79A, CD4, GPT
24thrombophilia29.8APOH, PROS1
25syphilis29.8APOH, CD4, CD79A
26infectious mononucleosis29.7CD4, CD79A
27lupus erythematosus29.7APOH, PROS1, CD79A
28systemic lupus erythematosus29.7CD79A, CD4, APOH
29rheumatoid arthritis29.7CD79A, CD4, APOH
30retinitis10.4
31encephalitis10.4
32keratitis10.3
33purpura fulminans10.3
34toxic shock syndrome10.2
35acute lymphocytic leukemia10.2
36hepatitis10.2
37smallpox10.2
38varicella virus antenatal infection10.2
39hematopoietic stem cell transplantation10.2
40streptococcal toxic-shock syndrome10.2
41rubella10.2
42necrotizing fasciitis10.2
43arthritis10.2
44neuritis10.2
45optic neuritis10.2
46bell's palsy10.2
47stromal keratitis10.2
48glomus tumor10.1ACTC1
49geniculate herpes zoster10.1
50acute retinal necrosis syndrome10.1

Graphical network of the top 20 diseases related to Chickenpox:



Diseases related to chickenpox

Symptoms for Chickenpox

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • blisters
  • sore throat
  • headache
  • fever
  • nausea
  • myalgia
  • anorexia

Drugs & Therapeutics for Chickenpox

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Chickenpox

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Chickenpox

About this section

Anatomical Context for Chickenpox

About this section
Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Chickenpox:

33
Skin, Tonsil, Testes, Liver, T cells, Breast, Lung, Eye

FMA organs/tissues related to Chickenpox:

14
Skin

Animal Models for Chickenpox or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Chickenpox:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.2CD79A, CD4, PROS1, MUC1
2MP:00028737.7CD79A, CD4, ACTC1, PROS1, MUC1
3MP:00053767.1APOH, MUC1, PROS1, ACTC1, CD4, CD79A

Publications for Chickenpox

About this section
Sources:
52PubMed
See all sources

Articles related to Chickenpox:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Natural alteration of antibody titers in a patient with immunoglobulin A deficiency after chickenpox over a 10-year period. (22181566)
2011
2
Retinitis and optic neuritis in a child with chickenpox: case report and review of literature. (20622712)
2010
3
Hemorrhagic Pericarditis in a child with primary varicella infection (chickenpox). (19332925)
2009
4
Exposition to chickenpox of two children with autoinflammatory syndromes under treatment with anakinra. (18172653)
2008
5
Chickenpox in adults - clinical management. (18555533)
2008
6
Chickenpox: very low mortality in France and the USA. (17460860)
2007
7
Occupationally related outbreak of chickenpox in an intensive care unit. (17709931)
2007
8
Acute retinal necrosis complicating chickenpox in a healthy adult--a case report and review of literature. (17984490)
2007
9
Delayed internal ophthalmoplegia and amblyopia following chickenpox. (16691403)
2006
10
Chickenpox in a geriatric patient. (16686890)
2006
11
Should acyclovir be prescribed for immunocompetent children presenting with chickenpox? (15908639)
2005
12
Delayed disseminated Staphylococcus aureus infection following chickenpox. (15151591)
2004
13
Managing shingles and postherpetic neuralgia. Reactivation of the chickenpox virus causes severe pain and rash in older adults. (15153382)
2004
14
A household study of chickenpox in Guinea-Bissau: intensity of exposure is a determinant of severity. (12423611)
2002
15
Chickenpox. (12603904)
2002
16
Deaths from chickenpox. Healthcare workers should not be forgotten. (11887882)
2002
17
Chickenpox vaccine snapped up instantly. (11894640)
2002
18
The magnitude of variation in temperature within a year has an effect on the seasonal variations of chickenpox incidence in Japan. (11349977)
2001
19
Serotesting versus presumptive varicella vaccination of adolescents with a negative or uncertain history of chickenpox. (11137902)
2001
20
Cost effectiveness of vaccination strategies in adults without a history of chickenpox. (10924649)
2000
21
New vaccine information materials for hepatitis B, Haemophilus influenzae type b (Hib), and varicella (chickenpox) vaccines, and revised vaccine information materials for measles, mumps, rubella (MMR) vaccines. Centers for Disease Control and Prevention (CDC), Department of Health and Human Services. Notice. (10557592)
1999
22
Managing exposure to chickenpox during pregnancy. New program. (9585843)
1998
23
Hemolytic anemia associated with cold agglutinin during chickenpox and a review of the literature. (9544167)
1998
24
Molecular biology of varicella-zoster virus. A review prepared for the UK Advisory Group on Chickenpox. (9514102)
1998
25
Acute childhood hemiplegia associated with chickenpox. (9568925)
1998
26
A boy with chickenpox whose fingers peeled. (9635952)
1998
27
Chickenpox immunisation in New Zealand. (9734530)
1998
28
Licensed preparations against hepatitis A and chickenpox: vaccine update--Part 2. (9051961)
1996
29
Surgical implications of necrotizing fasciitis in children with chickenpox. (8863250)
1996
30
The protective effect of immunologic boosting against zoster: an analysis in leukemic children who were vaccinated against chickenpox. (8568309)
1996
31
Acyclovir in chickenpox. (8660091)
1996
32
Acyclovir for childhood chickenpox. Cost is unjustified. (7833700)
1995
33
Chickenpox: an error in diagnosis by Hermann Boerhaave? (11616372)
1995
34
Immunisation against chickenpox. (7827547)
1995
35
Childhood vaccination against chickenpox: an analysis of benefits and costs. (8201469)
1994
36
Anti-epileptic therapy and fatal chickenpox. (8290426)
1993
37
Chickenpox in pregnancy. Pneumonitis more severe. (8518662)
1993
38
Chickenpox stroke in an adult. (8414047)
1993
39
Chickenpox in pregnancy. Acyclovir for uncomplicated chickenpox? (8357401)
1993
40
Purpura fulminans due to protein S deficiency following chickenpox. (1386247)
1992
41
Low antibody avidity in elderly chickenpox patients. (1321222)
1992
42
Subconjunctival hemorrhage in chickenpox. (2041675)
1991
43
Orchitis in chickenpox. (2282240)
1990
44
Chickenpox pneumonia: an association with pregnancy. (2330558)
1990
45
Chickenpox: where do we stand with treatment? (2319406)
1990
46
Transmission of chickenpox in a school setting prior to the observed exanthem. (2556025)
1989
47
Should children in renal failure be immunised against chickenpox before receiving a renal transplant. (2642094)
1989
48
Antiviral treatment in chickenpox and herpes zoster. (3339143)
1988
49
Treatment and prognosis of chickenpox in adult renal transplant recipients on cyclosporin. (3122120)
1987
50
Infantile herpes zoster ophthalmicus and acute hemiparesis following intrauterine chickenpox. (3498130)
1987

Variations for Chickenpox

About this section

Expression for genes affiliated with Chickenpox

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chickenpox

Search GEO for disease gene expression data for Chickenpox.

Pathways for genes affiliated with Chickenpox

About this section
Sources:
50PathCards, 30KEGG
See all sources

Pathways related to Chickenpox according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0CD79A, CD4

Compounds for genes affiliated with Chickenpox

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Chickenpox according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1s 1004510.1MUC1, ACTC1
2mucicarmine4510.1ACTC1, MUC1
3b 723459.9ACTC1, MUC1
4nash459.9GPT, ACTC1
5gluten459.9APOH, CD79A
6methanol45 2410.8APOH, ACTC1
7lactulose459.7CD79A, GPT
8clarithromycin45 1110.6GPT, CD79A
9isoniazid45 51 1111.6CD79A, GPT
10cardiolipin45 1110.6CD79A, APOH
11reticulin459.5CD79A, ACTC1, MUC1
12biotin45 24 1111.5CD79A, ACTC1, MUC1
13galactose459.5APOH, MUC1, CD79A
14sialic acid459.5APOH, MUC1, CD79A
15folate459.4CD79A, MUC1, APOH
16phospholipid459.4PROS1, MUC1, APOH
17ethanol45 51 24 1112.4GPT, APOH, MUC1
18ivig459.4CD79A, APOH, GPT
19warfarin45 51 24 1112.4CD79A, APOH, GPT
20vitamin b12459.4GPT, APOH, CD79A
21azathioprine45 3 51 1112.4CD79A, APOH, GPT
22dihydrotestosterone45 29 24 1112.4CD79A, PROS1, MUC1
23prednisolone45 29 1111.4CD79A, APOH, GPT
24valproate459.3CD79A, GPT
25hyaluronic acid45 2410.3CD79A, MUC1, GPT
26phosphorus459.3APOH, GPT
27glycogen45 2410.3ACTC1, MUC1, GPT
28fibrinogen459.2GPT, APOH, CD79A
29vitamin d459.1CD79A, PROS1, GPT
30hemocyanin459.1MUC1, CD4, CD79A
31mannan459.1MUC1, CD4, CD79A
32steroid459.0APOH, PROS1, ACTC1, CD79A
33mannose459.0APOH, CD4, CD79A
34testosterone45 61 24 1112.0MUC1, PROS1, ACTC1, CD79A
35paraffin459.0CD79A, ACTC1, MUC1
36estrogen459.0CD79A, ACTC1, MUC1, APOH
37methotrexate51 45 1111.0CD79A, MUC1, APOH, GPT
38dexamethasone45 51 29 1112.0MUC1, PROS1, ACTC1, CD79A
39neopterin458.9CD79A, CD4, GPT
40polysaccharide458.9MUC1, CD4, CD79A
41progesterone45 29 61 24 1112.9APOH, MUC1, ACTC1, CD4
42arginine458.8CD79A, PROS1, APOH, GPT
43glucose458.8GPT, APOH, MUC1, PROS1, ACTC1
44formaldehyde45 249.7CD79A, CD4, ACTC1, MUC1
45vegf458.7APOH, MUC1, PROS1, ACTC1, CD79A
46heparin45 29 24 1111.6APOH, PROS1, CD4, CD79A
47glutamate458.4CD79A, CD4, APOH, GPT
48cholesterol45 29 24 1111.3GPT, APOH, MUC1, PROS1, CD4
49calcium45 51 24 1111.2APOH, MUC1, PROS1, ACTC1, CD4
50creatinine458.2CD79A, GPT, APOH, MUC1, PROS1, ACTC1

GO Terms for genes affiliated with Chickenpox

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Chickenpox according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6PROS1, MUC1

Molecular functions related to Chickenpox according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.3CD4, APOH

Products for genes affiliated with Chickenpox

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chickenpox

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet