CHIK
MCID: CHK001
MIFTS: 44

Chikungunya (CHIK) malady

Infectious category

Summaries for Chikungunya

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Chikungunya (Pronunciation: \chik-en-gun-ye click to hear pronunciation) fever is a viral disease transmitted to humans by the bite of infected mosquitoes. Chikungunya virus is a member of the genus Alphavirus, in the family Togaviridae. Chikungunya fever is diagnosed based on symptoms, physical findings (e.g., joint swelling), laboratory testing, and the possibility of exposure to infected mosquitoes. There is no specific treatment for chikungunya fever; care is based on symptoms. Chikungunya fever is not usually fatal. Steps to prevent infection with chikungunya virus include use of insect repellent, protective clothing, and staying in areas with screens. Chikungunya virus was first isolated from the blood of a febrile patient in Tanzania in 1953, and has since been cited as the cause of numerous human epidemics in many areas of Africa and Asia and most recently in limited areas of Europe. Chikungunya virus is not currently found in the United States.

MalaCards: Chikungunya, also known as chikungunya virus infection, is related to yellow fever and venezuelan equine encephalitis, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is MT-ND5 (mitochondrially encoded NADH dehydrogenase 5), and among its related pathways is Influenza A. The compounds alanine and zinc have been mentioned in the context of this disorder. Affiliated tissues include joint, whole blood and brain.

Disease Ontology:8 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia:64 Chikungunya (in the Makonde language \"that which bends up\") virus (CHIKV) is an arthropod-borne virus,... more...

Aliases & Classifications for Chikungunya

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
chikungunya:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

chikungunya 8 43 10 49
chikungunya virus infection 43 61
chikungunya fever 8 43
arbovirus a chikungunya type 43
chikv infection 43
chik 43


External Ids:

Disease Ontology8 DOID:0050012
ICD10 via Orphanet26 A92.0
ICD1025 A92.0

Related Diseases for Chikungunya

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Clinical Features for Chikungunya

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • fever
  • arthralgia
  • maculopapular rash

Drugs & Therapeutics for Chikungunya

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chikungunya

Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Search CenterWatch for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Chikungunya:

33
Whole blood, Brain, Liver, Salivary gland, Skin, Monocytes, T cells

FMA organs/tissues related to Chikungunya:

14
Joint

Animal Models for Chikungunya or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Chikungunya

Sources:
51PubMed
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Articles related to Chikungunya:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Chikungunya Vaccine Candidate is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically-monitored Disease Following a Single Dose. (24403555)
2014
2
Anti-Chikungunya Viral Activities of Aplysiatoxin-Related Compounds from the Marine Cyanobacterium Trichodesmium erythraeum. (24394406)
2014
3
Functional Crosstalk between Distant Domains of Chikungunya Virus Non-Structural Protein 2 Is Decisive For Its RNA-Modulating Activity. (24407286)
2014
4
Outbreak of chikungunya virus infection, Vanimo, Papua New Guinea. (23965757)
2013
5
Administration of E2 and NS1 siRNAs inhibit chikungunya virus replication in vitro and protects mice infected with the virus. (24040429)
2013
6
The 2005-2007 Chikungunya epidemic in RAcunion: ambiguous etiologies, memories, and meaning-making. (23406067)
2013
7
Identification of structural motifs in the E2 glycoprotein of Chikungunya involved in virus-host interaction. (23025271)
2013
8
Chikungunya virus: an update on antiviral development and challenges. (23684571)
2013
9
Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins. (23911992)
2013
10
Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. (23201456)
2013
11
Evidence for endemic chikungunya virus infections in Bandung, Indonesia. (24205417)
2013
12
Reemergence of chikungunya virus in Bo, Sierra Leone. (23764023)
2013
13
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. (23380636)
2013
14
Chikungunya virus infection: an overview. (23912863)
2013
15
High efficiency of temperate Aedes albopictus to transmit chikungunya and dengue viruses in the Southeast of France. (23527259)
2013
16
Photochemical inactivation of chikungunya virus in human apheresis platelet components by amotosalen and UVA light. (23530077)
2013
17
Use of human monoclonal antibodies to treat Chikungunya virus infection. (23125446)
2013
18
Travelers as sentinels for chikungunya fever, Brazil. (22377013)
2012
19
Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. (22837213)
2012
20
Coinfection with dengue and chikungunya--a case report. (23738415)
2012
21
NMR structure, localization, and vesicle fusion of Chikungunya virus fusion peptide. (22978677)
2012
22
US Military contributions to the global response to pandemic chikungunya. (22940380)
2012
23
Post chikungunya brain stem encephalitis. (23029750)
2012
24
Neurodevelopmental outcome of neonates with vertically transmitted Chikungunya fever with encephalopathy. (22484743)
2012
25
Impaired quality of life after chikungunya virus infection: a 2-year follow-up study. (22427407)
2012
26
Risk for emergence of dengue and chikungunya virus in Israel. (22305194)
2012
27
Chikungunya outbreak--Cambodia, February-March 2012. (22992571)
2012
28
Infection by chikungunya virus modulates the expression of several proteins in Aedes aegypti salivary glands. (23153178)
2012
29
Cutaneous manifestations of Chikungunya fever: significance. (22484757)
2012
30
Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study. (21767452)
2012
31
The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry. (22889614)
2012
32
Recombinant CHIK virus E1 coat protein of 11 KDa with antigenic domains for the detection of Chikungunya. (21798263)
2011
33
A study of Chikungunya outbreak in Delhi. (23781642)
2011
34
The invaders: phylogeography of dengue and chikungunya viruses Aedes vectors, on the South West islands of the Indian Ocean. (21827872)
2011
35
Entomological study of chikungunya infections in the State of Kelantan, Malaysia. (21727669)
2011
36
Chikungunya in Southeast Asia: understanding the emergence and finding solutions. (21775183)
2011
37
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis. (21881117)
2011
38
Stability of yellow fever virus under recombinatory pressure as compared with chikungunya virus. (21826243)
2011
39
Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence. (22174678)
2011
40
Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells. (21762510)
2011
41
Chikungunya virus, southeastern France. (21529410)
2011
42
Different lineages of Chikungunya virus in Equatorial Guinea in 2002 and 2006. (20207882)
2010
43
Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus. (19725768)
2010
44
Diagnosis of Chikungunya fever in an Indian population by an indirect enzyme-linked immunosorbent assay protocol based on an antigen detection assay: a prospective cohort study. (20007365)
2010
45
Evaluation of Chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks. (20651930)
2010
46
Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice. (20665754)
2010
47
Dengue and chikungunya infections in travelers. (20581669)
2010
48
Development of field-based real-time reverse transcription-polymerase chain reaction assays for detection of Chikungunya and O'nyong-nyong viruses in mosquitoes. (19815886)
2009
49
Failure to demonstrate experimental vertical transmission of the epidemic strain of Chikungunya virus in Aedes albopictus from La RAcunion Island, Indian Ocean. (19722089)
2009
50
Presence of autoimmune antibody in chikungunya infection. (19997520)
2009

Genetic Variations for Chikungunya

Expression for genes affiliated with Chikungunya

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

Sources:
30KEGG
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Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6OAS3, FURIN, RSAD2, MAVS, C1QBP

Compounds for genes affiliated with Chikungunya

Sources:
45Novoseek, 24HMDB
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Compounds related to Chikungunya according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine459.6MAP3K14, MIF, ABCB7, FURIN, MT-ND5
2zinc45 2410.2FURIN, ABCB7, MIF, SH2D3A, C1QBP

GO Terms for genes affiliated with Chikungunya

Sources:
16Gene Ontology
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Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.3OAS3, IFI44L, PHB, DDX60, SH2D3C, MAP3K14

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral genome replicationGO:0450719.9MAVS, RSAD2, OAS3
2response to virusGO:0096159.9OAS3, RSAD2, DDX60
3defense response to virusGO:0516079.5OAS3, RSAD2, MAVS, DDX60, IFI44L
4innate immune responseGO:0450879.1C1QBP, DDX60, MAVS, MIF, RSAD2

Products for genes affiliated with Chikungunya

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chikungunya

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet