CK
MCID: CHK001
MIFTS: 51

Chikungunya (CK) malady

Genetic diseases, Rare diseases, Infectious diseases, Neuronal diseases, Fetal diseases, Bone diseases categories
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Summaries for Chikungunya

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Disease Ontology:8 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

MalaCards based summary: Chikungunya, also known as ck syndrome, is related to myocardial infarction and acute myocardial infarction, and has symptoms including An important gene associated with Chikungunya is NSDHL (NAD(P) dependent steroid dehydrogenase-like), and among its related pathways are Influenza A and Hepatitis C. Affiliated tissues include joint, monocytes and testes, and related mouse phenotype cardiovascular system.

CDC:3 Click here to view a Digital Press Kit on chikungunya from the CDC News Room.

Wikipedia:65 Chikungunya (/?t??k?n???nj?/CHI-k?n-GUUN-y?; Makonde for \"that which bends up\") is an infection caused... more...

Description from OMIM:46 300831

Aliases & Classifications for Chikungunya

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 46OMIM, 10DISEASES, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Chikungunya, Aliases & Descriptions:

Name: Chikungunya 8 42 10 48
Ck Syndrome 46 48 62
Chikungunya Virus Infection 42 62
Chikungunya Fever 8 42
Ck 42 20
 
X-Linked Intellectual Disability - Microcephaly - Cortical Malformation - Thin Habitus 48
Arbovirus a Chikungunya Type 42
Chikv Infection 42
Chik 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
ck syndrome:
Inheritance: X-linked recessive; Prevalence: <1/1000000; Age of onset: Neonatal/infancy
chikungunya:
Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:0050012
OMIM46 300831
ICD10 via Orphanet26 A92.0
ICD1025 A92.0

Related Diseases for Chikungunya

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Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Symptoms for Chikungunya

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Symptoms by clinical synopsis from OMIM:

300831

Clinical features from OMIM:

300831

HPO human phenotypes related to Chikungunya:

(show all 33)
id Description Frequency HPO Source Accession
1 high palate HP:0000218
2 microcephaly HP:0000252
3 malar flattening HP:0000272
4 narrow face HP:0000275
5 long face HP:0000276
6 retrognathia HP:0000278
7 epicanthus HP:0000286
8 micrognathia HP:0000347
9 posteriorly rotated ears HP:0000358
10 prominent nasal bridge HP:0000426
11 strabismus HP:0000486
12 upslanted palpebral fissure HP:0000582
13 dental crowding HP:0000678
14 aggressive behavior HP:0000718
15 irritability HP:0000737
16 delayed speech and language development HP:0000750
17 hyperactivity HP:0000752
18 intellectual disability HP:0001249
19 seizures HP:0001250
20 global developmental delay HP:0001263
21 generalized hypotonia HP:0001290
22 pachygyria HP:0001302
23 joint hypermobility HP:0001382
24 x-linked recessive inheritance HP:0001419
25 slender build HP:0001533
26 polymicrogyria HP:0002126
27 sleep disturbance HP:0002360
28 scoliosis HP:0002650
29 kyphosis HP:0002808
30 abnormal cortical bone morphology HP:0003103
31 hyperlordosis HP:0003307
32 almond-shaped palpebral fissure HP:0007874
33 abnormality of digit HP:0011297

Drugs & Therapeutics for Chikungunya

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Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

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Genetic tests related to Chikungunya:

id Genetic test Affiliating Genes
1 Ck Syndrome20

Anatomical Context for Chikungunya

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MalaCards organs/tissues related to Chikungunya:

32
Monocytes, Testes, Eye, Salivary gland, Bone, Brain, Liver, Skin, T cells

FMA organs/tissues related to Chikungunya:

14
Joint

Animal Models for Chikungunya or affiliated genes

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MGI Mouse Phenotypes related to Chikungunya:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7MAVS, NSDHL, ABCB7

Publications for Chikungunya

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Articles related to Chikungunya:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012. (24499011)
2014
2
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication. (25282648)
2014
3
Chikungunya virus nsP2-mediated host shut-off disables the unfolded protein response. (25395592)
2014
4
Concurrent outbreaks of dengue, chikungunya and Zika virus infections - an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014. (25345518)
2014
5
Genomes to hits in silico - a country path today, a highway tomorrow: a case study of chikungunya. (23260020)
2013
6
Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces. (24009512)
2013
7
Development of a high-throughput antiviral assay for screening inhibitors of chikungunya virus and generation of drug-resistant mutations in cultured cells. (23821286)
2013
8
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. (23275491)
2013
9
Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. (24129946)
2013
10
Outbreak of chikungunya virus infection, Vanimo, Papua New Guinea. (23965757)
2013
11
Travel-Associated Chikungunya Cases in South Korea during 2009-2010. (24159550)
2013
12
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. (23936572)
2013
13
Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation. (24126361)
2013
14
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. (23864632)
2013
15
Travelers as sentinels for chikungunya fever, Brazil. (22377013)
2012
16
High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand. (22188545)
2012
17
Chikungunya myeloradiculopathy: a rare complication. (23326078)
2012
18
Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae). (21750871)
2012
19
Chikungunya virus infection of corneal grafts. (22706183)
2012
20
Differential diagnosis of Chikungunya, dengue viral infection and other acute febrile illnesses in children. (22301475)
2012
21
Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. (22837213)
2012
22
Coinfection with dengue and chikungunya--a case report. (23738415)
2012
23
Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus. (22546647)
2012
24
Chikungunya virus infection, a threat to public health. (22561790)
2012
25
Prevalence of chikungunya in urban field practice area of a private medical college, chennai. (21976797)
2011
26
Isolation and molecular characterization of Chikungunya virus from the Andaman and Nicobar archipelago, India: evidence of an East, Central, and South African genotype. (22136155)
2011
27
Chikungunya virus: host pathogen interaction. (21412934)
2011
28
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. (21811589)
2011
29
Chikungunya epidemic-related mortality. (21073766)
2011
30
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. (22014740)
2011
31
Clinical Profile of Chikungunya Patients during the Epidemic of 2007 in Kerala, India. (21887052)
2011
32
Competitive suppression between chikungunya and dengue virus in Aedes albopictus c6/36 cell line. (22299407)
2011
33
Exposure to chikungunya virus and adult longevity in Aedes aegypti (L.) and Aedes albopictus (Skuse). (20618649)
2010
34
Different lineages of Chikungunya virus in Equatorial Guinea in 2002 and 2006. (20207882)
2010
35
Urological manifestations of Chikungunya fever: A single centre experience. (20981198)
2010
36
Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus. (19725768)
2010
37
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. (20952847)
2010
38
CHIKVPRO - a protein sequence annotation database for chikungunya virus. (21346870)
2010
39
First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality! (21040155)
2010
40
Reemergence of Chikungunya virus in Indian Subcontinent. (23637474)
2010
41
Tracing the path of Chikungunya virus--evolution and adaptation. (20654736)
2010
42
Chikungunya virus infection during pregnancy, Reunion, France, 2006. (20202416)
2010
43
Suppressing Aedes albopictus, an emerging vector of dengue and chikungunya viruses, by a novel combination of a monomolecular film and an insect-growth regulator. (20439963)
2010
44
Breeding potential of Aedes albopictus (Skuse, 1895) in chikungunya affected areas of Kerala, India. (21245624)
2010
45
Whole-genome characterisation of Chikungunya virus from Aedes albopictus collected in Thailand. (20507700)
2010
46
Chikungunya: an emerging and spreading arthropod-borne viral disease. (20009275)
2009
47
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak. (19857273)
2009
48
A suspicion of chikungunya leading to a diagnosis of angioimmunoblastic T-cell lymphoma. (19173091)
2009
49
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. (20003320)
2009
50
Immuno-biology of Chikungunya and implications for disease intervention. (19737625)
2009

Variations for Chikungunya

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Clinvar genetic disease variations for Chikungunya:

6
id Gene Name Type Significance SNP ID Assembly Location
1NSDHLNM_001129765.1(NSDHL): c.1098dupT (p.Arg367Serfs)duplicationPathogenicrs121909834GRCh37Chr X, 152037636: 152037637
2NSDHLNM_001129765.1(NSDHL): c.696_698delGAA (p.Lys232del)deletionPathogenicrs121909833GRCh37Chr X, 152036124: 152036126

Expression for genes affiliated with Chikungunya

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Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1MAVS, OAS3
29.1MAVS, OAS3

Compounds for genes affiliated with Chikungunya

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GO Terms for genes affiliated with Chikungunya

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Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.5NSDHL, OAS3

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.1MAVS, OAS3
2negative regulation of viral genome replicationGO:0450718.8MAVS, OAS3

Products for genes affiliated with Chikungunya

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  • Proteins
  • Lysates

Sources for Chikungunya

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet