CK
MCID: CHK001
MIFTS: 54

Chikungunya (CK) malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Chikungunya

Aliases & Descriptions for Chikungunya:

Name: Chikungunya 12 50 56 41 14
Chikungunya Fever 12 50 3 69
Ck 50 3
Arbovirus a Chikungunya Type 50
Chikungunya Virus Infection 50
Chikv Infection 50
Chik 50

Characteristics:

Orphanet epidemiological data:

56
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
Orphanet 56 ORPHA324625
ICD10 via Orphanet 34 A92.0
ICD10 33 A92.0

Summaries for Chikungunya

MedlinePlus : 41 chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and zika virus. rarely, it can spread from mother to newborn around the time of birth. it may also possibly spread through infected blood. there have been outbreaks of chikungunya virus in africa, asia, europe, the indian and pacific oceans, the caribbean, and central and south america. most people who are infected will have symptoms, which can be severe. they usually start 3-7 days after being bitten by an infected mosquito. the most common symptoms are fever and joint pain. other symptoms may include headache, muscle pain, joint swelling, and rash. most people feel better within a week. in some cases, however, the joint pain may last for months. people at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. a blood test can show whether you have chikungunya virus. there are no vaccines or medicines to treat it. drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. the best way to prevent chikungunya infection is to avoid mosquito bites: use insect repellent wear clothes that cover your arms, legs, and feet stay in places that have air conditioning or that use window and door screens centers for disease control and prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to measles and rift valley fever, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs chloroquine and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and monocytes, and related phenotype is hematopoietic system.

CDC : 3 Click here to view a Digital Press Kit on chikungunya from the CDC News Room.

Disease Ontology : 12 A viral infectious disease that results_in infection located in joint, has material basis in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia : 71 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
id Related Disease Score Top Affiliating Genes
1 measles 29.6 IL1B IL6 TNF
2 rift valley fever 29.6 IL1B IL6 TNF
3 neuropathy 29.4 IL1B IL6 TNF
4 choroiditis 29.4 IL1B IL6 TNF
5 rheumatoid arthritis 28.7 CCL5 CD40LG IL1B IL6 MIF TNF
6 ck syndrome 12.3
7 hypermethioninemia with deficiency of s-adenosylhomocysteine hydrolase 10.8
8 child syndrome 10.8
9 isolated hyperckemia 10.8
10 myocardial infarction 10.3
11 oculomotor nerve paralysis 10.2 IL1B IL6
12 acute myocardial infarction 10.2
13 common peroneal nerve lesion 10.2 IL1B IL6
14 intussusception 10.2 IL1B TNF
15 dyslexia 5 10.2 IL6 TNF
16 hereditary elliptocytosis 10.2 BST2 OAS1 OAS3
17 aortic atherosclerosis 10.2 IL6 TNF
18 degenerative disc disease 10.2 IL6 TNF
19 tau syndrome 10.2 IL1B TNF
20 stocco dos santos syndrome 10.1 IL1B TNF
21 arthritis 10.1
22 breast apocrine carcinoma in situ 10.1 CCL5 IL1B IL6
23 unilateral multicystic dysplastic kidney 10.1 IL6 TNF
24 anal paget's disease 10.1 IL1B IL6 TNF
25 bipolar i disorder 10.1 IL1B IL6 TNF
26 tinea capitis 10.1 IL1B IL6 TNF
27 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL1B IL6 TNF
28 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
29 mikulicz disease 10.1 IL1B IL6 TNF
30 acquired thrombocytopenia 10.1 IL1B IL6 TNF
31 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL1B IL6 TNF
32 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.1 CCL5 IL6 TNF
33 gonococcal endophthalmia 10.1 IL1B IL6 TNF
34 ectodermal dysplasia bartalos type 10.1 IL1B IL6 TNF
35 migraine with aura 10.1 IL1B IL6 TNF
36 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1B IL6 TNF
37 keratoconus 10.1 IL1B IL6 TNF
38 motility-related diarrhea 10.1 IL1B IL6 TNF
39 splenic artery aneurysm 10.1 IL1B IL6 TNF
40 inappropriate adh syndrome 10.1 IL1B IL6 TNF
41 central nervous system lymphoma 10.1 IL1B IL6 TNF
42 labyrinthitis 10.1 IL1B IL6 TNF
43 pancreas lymphoma 10.1 IL1B IL6 TNF
44 thymic neuroendocrine carcinoma 10.1 IL6 TNF
45 blepharochalasis 10.1 IL1B IL6 TNF
46 chordoid meningioma 10.1 IL1B IL6 TNF
47 nasopharyngitis 10.1 IL1B IL6 TNF
48 erb-duchenne and dejerine-klumpke palsies 10.1 CCL5 IL6 TNF
49 infancy electroclinical syndrome 10.1 IL1B IL6 TNF
50 stenosis of lacrimal sac 10.1 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 MIF TNF CCL5 CD40LG DDX58 IL1B

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
2 Anti-Inflammatory Agents Phase 3
3 Anti-Inflammatory Agents, Non-Steroidal Phase 3
4 Antirheumatic Agents Phase 3
5 Analgesics Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Anthelmintics Phase 3
8 Anti-Infective Agents Phase 3
9 Antimalarials Phase 3
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Chloroquine diphosphate Phase 3 50-63-5
13 Peripheral Nervous System Agents Phase 3
14 Antibodies Phase 1, Phase 2
15 gamma-Globulins Phase 1, Phase 2
16 Immunoglobulins Phase 1, Phase 2
17 Immunoglobulins, Intravenous Phase 1, Phase 2
18 Rho(D) Immune Globulin Phase 1, Phase 2
19 Pharmaceutical Solutions Phase 2
20 Vaccines Phase 2,Phase 1
21
Mechlorethamine Approved 51-75-2 4033
22
Methotrexate Approved 1959-05-2, 59-05-2 126941
23
Methylprednisolone Approved, Vet_approved 83-43-2 6741
24
Pantoprazole Approved 102625-70-7 4679
25
Prednisolone Approved, Vet_approved 50-24-8 5755
26
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
27
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
28 Antimetabolites
29 Antimetabolites, Antineoplastic
30 Dermatologic Agents
31 Folic Acid Antagonists
32 Immunosuppressive Agents
33 Methylprednisolone acetate
34 Methylprednisolone Hemisuccinate
35 Nucleic Acid Synthesis Inhibitors
36 Prednisolone acetate
37 Prednisolone hemisuccinate
38 Prednisolone phosphate
39 Vitamin B Complex
40 Folate Nutraceutical
41 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Recruiting NCT02861586 Phase 2
5 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Active, not recruiting NCT02562482 Phase 2
6 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Not yet recruiting NCT03101111 Phase 2
7 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
8 Phase I Trial of Measles Vectored Chikungungya Vaccine Not yet recruiting NCT03028441 Phase 1
9 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
10 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952
11 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
12 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
13 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
14 Zika and Microcephaly: Case-control Study Completed NCT02741882
15 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Recruiting NCT02714985
16 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Recruiting NCT02174341
17 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Recruiting NCT02901509
18 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Recruiting NCT02831699
19 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
20 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
21 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
22 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444
23 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Active, not recruiting NCT02281123
24 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Active, not recruiting NCT03090685
25 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Active, not recruiting NCT03058471
26 Chikungunya Arthritis in the Americas Not yet recruiting NCT02463968
27 Applying Wolbachia to Eliminate Dengue Not yet recruiting NCT03055585
28 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Not yet recruiting NCT03106714

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

MalaCards organs/tissues related to Chikungunya:

39
Testes, Heart, Monocytes, T Cells, Bone, Brain, Salivary Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

18
Joint

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 654)
id Title Authors Year
1
Epidemiology of Chikungunya Virus Outbreaks in Guadeloupe and Martinique, 2014: An Observational Study in Volunteer Blood Donors. ( 28081120 )
2017
2
Toxicity of ar-curcumene and epi-I^-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors. ( 27918946 )
2017
3
Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. ( 28067803 )
2017
4
Spectral characterisation, antiviral activities, in silico ADMET and molecular docking of the compounds isolated from Tectona grandis to chikungunya virus. ( 28063412 )
2017
5
Do Two Screening Tools for Chikungunya Virus Infection that were Developed among Younger Population Work Equally as Well in Patients Aged over 65 Years? ( 28056031 )
2017
6
Impaired NK cell functionality and increased TNF-I+ production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis. ( 28213049 )
2017
7
Epidemic outbreak of Chikungunya in two neighboring towns in the Colombian Caribbean: a survival analysis. ( 28074128 )
2017
8
Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain. ( 28077641 )
2017
9
Chikungunya Infection in Hospitalized Febrile Infants Younger Than 3 Months of Age. ( 28060043 )
2017
10
Glutathionylation of chikungunya nsP2 protein affects protease activity. ( 27984114 )
2017
11
Resolution of a Chikungunya Outbreak in a Prospective Cohort, Cebu, Philippines, 2012-2014. ( 27649081 )
2016
12
High yield expression and purification of Chikungunya virus E2 recombinant protein and its evaluation for serodiagnosis. ( 27180040 )
2016
13
Activities of proteasome and m-calpain are essential for Chikungunya virus replication. ( 27206501 )
2016
14
Chikungunya fever outbreak in Rio de Janeiro, Brazil: Ultrasonographic aspects of musculoskeletal complications. ( 27619412 )
2016
15
Western Blot Detection of Human Anti-Chikungunya Virus Antibody with Recombinant Envelope 2 Protein. ( 27180586 )
2016
16
Structure-function relationship of Chikungunya nsP2 protease: A comparative study with papain. ( 28054451 )
2016
17
Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. ( 27581733 )
2016
18
Simultaneous detection of Zika, Chikungunya and Dengue viruses by a multiplex real-time RT-PCR assay. ( 27614319 )
2016
19
Comprehensive Genome-Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus. ( 27654297 )
2016
20
Chikungunya Virus Infection Manifesting as Intermediate Uveitis. ( 28010143 )
2016
21
Chikungunya Fever With Seizures, Myocarditis, and Severe Thrombocytopenia in a Child With Osteosarcoma. ( 27128980 )
2016
22
Pharmacologic management of pain in patients with Chikungunya: a guideline. ( 28001212 )
2016
23
Molecular Characterisation of Clinical Isolates of Chikungunya Virus: A Study from Tertiary Care Hospitals in Southern India. ( 27134872 )
2016
24
Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus. ( 27190548 )
2016
25
Chikungunya Virus Disease: An Emerging Challenge for the Rheumatologist. ( 27219309 )
2016
26
Reduced Incidence of Chikungunya Virus Infection in Communities with Ongoing Aedes Aegypti Mosquito Trap Intervention Studies - Salinas and Guayama, Puerto Rico, November 2015-February 2016. ( 27171600 )
2016
27
Sequential Chikungunya and Zika Virus Infections in a Traveler from Honduras. ( 27601517 )
2016
28
A chikungunya fever vaccine utilizing an insect-specific virus platform. ( 27991917 )
2016
29
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. ( 27105216 )
2016
30
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. ( 27177310 )
2016
31
Imported Chikungunya fever case in Greece in June 2014 and public health response. ( 27159571 )
2016
32
Chikungunya virus-associated encephalitis: A cohort study on La RAcunion Island, 2005-2009. ( 27217467 )
2016
33
Chikungunya Fever Cases Identified in the Veterans Health Administration System, 2014. ( 27144588 )
2016
34
Early clearance of Chikungunya virus in children is associated with a strong innate immune response. ( 27180811 )
2016
35
Leukemoid Reaction in Chikungunya Fever. ( 27437276 )
2016
36
Chikungunya and Coronary Artery Bypass Graft Surgery. ( 28082029 )
2016
37
Carpal Tunnel Syndrome after Chikungunya Infection. ( 27989767 )
2016
38
Antiviral activity of the combination of interferon and ribavirin against chikungunya virus: are the results conclusive? ( 28003356 )
2016
39
Febrile or Exanthematous Illness Associated with Zika, Dengue, and Chikungunya Viruses, Panama. ( 27139219 )
2016
40
Chikungunya virus infections among travellers returning to Spain, 2008 to 2014. ( 27631156 )
2016
41
Fatal leptospirosis and chikungunya co-infection: Do not forget leptospirosis during chikungunya outbreaks. ( 27413690 )
2016
42
A comparison of compliance rates with anti-vectorial protective measures during travel to regions with dengue or chikungunya activity, and regions endemic for Plasmodium falciparum malaria. ( 27378367 )
2016
43
Characterization of a Chikungunya virus strain isolated from banked patients' sera. ( 27590311 )
2016
44
Inhibition of chikungunya virus by picolinate that targets viral capsid protein. ( 27614702 )
2016
45
Vector Competence of Aedes aegypti and Aedes polynesiensis Populations from French Polynesia for Chikungunya Virus. ( 27144888 )
2016
46
Impact of Autocidal Gravid Ovitraps on Chikungunya Virus Incidence in Aedes aegypti (Diptera: Culicidae) in Areas With and Without Traps. ( 28031347 )
2016
47
Viremia and Clinical Presentation in Nicaraguan Patients Infected with Zika Virus, Chikungunya Virus, and Dengue Virus. ( 27578819 )
2016
48
Erratum: Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil. ( 27635304 )
2016
49
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. ( 28039020 )
2016
50
A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint. ( 28001232 )
2016

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 48)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 BST2 CCL5 CD209 CD40LG DDX58 IL1B
2
Show member pathways
12.97 BST2 CCL5 CD40LG DDX58 IL1B IL6
3
Show member pathways
12.84 CCL5 DDX58 IL1B IL6 MAVS TNF
4
Show member pathways
12.84 CCL5 CD209 IL1B IL6 MAVS OAS1
5
Show member pathways
12.64 CCL5 DDX58 IL1B IL6 MAVS TNF
6
Show member pathways
12.62 CD40LG IL1B IL6 TNF
7
Show member pathways
12.46 BST2 DDX58 OAS1 OAS3
8
Show member pathways
12.37 CD40LG IL1B IL6 TNF
9 12.36 CCL5 CD40LG DDX58 IL1B MAVS OAS1
10
Show member pathways
12.28 CCL5 IL1B IL6 TNF
11
Show member pathways
12.23 IL1B IL6 MIF TNF
12 12.2 CD209 IL1B IL6 TNF
13 11.99 IL6 MIF TNF
14 11.97 IL1B IL6 MIF TNF
15
Show member pathways
11.97 CCL5 CD209 DDX58 IL1B IL6 MAVS
16 11.95 DDX58 MAVS OAS1 OAS3 TNF
17 11.93 CD209 IL6 TNF
18 11.92 IL1B IL6 TNF
19 11.91 CCL5 IL1B IL6 TNF
20
Show member pathways
11.88 IL1B IL6 TNF
21 11.85 IL1B IL6 TNF
22 11.84 CD40LG DDX58 IL1B TNF
23 11.83 IL1B IL6 TNF
24 11.82 IL1B IL6 TNF
25 11.8 CCL5 IL1B IL6 TNF
26 11.72 IL1B IL6 TNF
27 11.72 CD209 IL1B IL6 TNF
28 11.68 CD40LG IL6 TNF
29
Show member pathways
11.64 BST2 IL1B IL6 OAS1 OAS3 TNF
30 11.6 CCL5 IL1B IL6 TNF
31
Show member pathways
11.57 CD40LG IL1B IL6 MIF TNF
32 11.56 IL1B IL6 TNF
33 11.47 IL1B IL6 TNF
34 11.47 CCL5 IL1B IL6 TNF
35 11.45 CD40LG IL1B IL6 TNF
36 11.35 IL1B IL6 TNF
37 11.34 IL1B IL6 TNF
38 11.34 CCL5 IL1B IL6
39 11.29 IL1B IL6 TNF
40 11.27 IL1B IL6 TNF
41 11.25 IL1B IL6 TNF
42 11.14 CCL5 CD40LG IL1B IL6 TNF
43
Show member pathways
11.11 DDX58 MAVS OAS1
44 11.05 IL1B TNF
45 11.04 IL6 TNF
46 10.97 IL6 TNF
47 10.89 IL1B TNF
48 10.86 IL1B IL6

GO Terms for Chikungunya

Cellular components related to Chikungunya according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL5 CD209 CD40LG IL1B IL6 MIF
2 external side of plasma membrane GO:0009897 9.56 CD209 CD40LG IL6 TNF
3 extracellular space GO:0005615 9.5 CCL5 CD40LG IL1B IL6 MIF OAS3
4 cell surface GO:0009986 9.1 BST2 CD209 CD40LG MIF PHB TNF

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show all 48)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 CD209 DDX58 MAVS MIF OAS1 OAS3
2 positive regulation of gene expression GO:0010628 9.97 DDX58 IL1B IL6 PHB TNF
3 innate immune response GO:0045087 9.95 BST2 CD209 DDX58 MAVS MIF OAS1
4 inflammatory response GO:0006954 9.93 CCL5 CD40LG IL1B IL6 MIF TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 BST2 IL1B MAVS TNF
6 immune response GO:0006955 9.91 CCL5 CD40LG IL1B IL6 OAS1 OAS3
7 positive regulation of protein phosphorylation GO:0001934 9.89 IL1B MAVS MIF TNF
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 CCL5 IL6 MIF PHB TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 CD40LG IL1B IL6 TNF
10 cellular response to organic cyclic compound GO:0071407 9.84 CCL5 IL1B TNF
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 IL6 MIF TNF
12 regulation of insulin secretion GO:0050796 9.83 CCL5 IL1B TNF
13 type I interferon signaling pathway GO:0060337 9.82 BST2 OAS1 OAS3
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 CCL5 IL6 TNF
15 humoral immune response GO:0006959 9.81 BST2 IL6 TNF
16 positive regulation of T cell proliferation GO:0042102 9.8 CCL5 CD40LG IL1B IL6
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B IL6 TNF
18 protein kinase B signaling GO:0043491 9.73 CCL5 IL1B TNF
19 positive regulation of interleukin-6 production GO:0032755 9.73 DDX58 IL1B IL6 TNF
20 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.72 DDX58 IL1B IL6 MAVS TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL5 IL1B TNF
22 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B TNF
23 positive regulation of defense response to virus by host GO:0002230 9.7 DDX58 MAVS
24 positive regulation of JAK-STAT cascade GO:0046427 9.7 CCL5 IL6
25 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
26 leukocyte cell-cell adhesion GO:0007159 9.7 CCL5 CD209 CD40LG
27 positive regulation of chemokine production GO:0032722 9.69 IL6 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
29 positive regulation of transcription factor import into nucleus GO:0042993 9.69 DDX58 MAVS
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
32 positive regulation of protein import into nucleus, translocation GO:0033160 9.68 IL6 MAVS
33 positive regulation of interferon-alpha production GO:0032727 9.68 DDX58 MAVS
34 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
35 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 DDX58 IL1B
36 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
37 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
38 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.64 IL6 TNF
39 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
40 defense response to virus GO:0051607 9.63 BST2 DDX58 IL6 MAVS OAS1 OAS3
41 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
42 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
43 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.61 MIF TNF
44 RIG-I signaling pathway GO:0039529 9.58 DDX58 MAVS
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
46 positive regulation of interleukin-8 production GO:0032757 9.56 DDX58 IL1B MAVS TNF
47 response to virus GO:0009615 9.43 BST2 CCL5 DDX58 OAS1 OAS3 TNF
48 negative regulation of viral genome replication GO:0045071 9.1 BST2 CCL5 MAVS OAS1 OAS3 TNF

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.33 DDX58 OAS1 OAS3
2 cytokine activity GO:0005125 9.1 CCL5 CD40LG IL1B IL6 MIF TNF
3 2-5-oligoadenylate synthetase activity GO:0001730 8.96 OAS1 OAS3

Sources for Chikungunya

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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