CHIK
MCID: CHK001
MIFTS: 48

Chikungunya (CHIK) malady

Infectious diseases category

Summaries for Chikungunya

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Chikungunya (pronunciation: \chik-en-gun-ye click to hear pronunciation) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. Chikungunya virus is not currently found in the United States. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

MalaCards: Chikungunya, also known as chikungunya virus infection, is related to yellow fever and venezuelan equine encephalitis, and has symptoms including maculopapular rash, arthralgia and fever. An important gene associated with Chikungunya is MT-ND5 (mitochondrially encoded NADH dehydrogenase 5), and among its related pathways is Influenza A. The compounds alanine and zinc have been mentioned in the context of this disorder. Affiliated tissues include joint, monocytes and testes.

Disease Ontology:8 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia:63 Chikungunya (in the Makonde language \"that which bends up\") virus (CHIKV) is an arthropod-borne virus,... more...

Aliases & Classifications for Chikungunya

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
chikungunya:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

chikungunya 8 42 10 48
chikungunya virus infection 42 60
chikungunya fever 8 42
arbovirus a chikungunya type 42
chikv infection 42
chik 42


External Ids:

Disease Ontology8 DOID:0050012
ICD10 via Orphanet26 A92.0
ICD1025 A92.0

Related Diseases for Chikungunya

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Clinical Features for Chikungunya

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8Disease Ontology
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Symptoms:

8
  • maculopapular rash
  • arthralgia
  • fever

Drugs & Therapeutics for Chikungunya

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chikungunya

Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Search CenterWatch for Chikungunya

Genetic Tests for Chikungunya

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Anatomical Context for Chikungunya

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Chikungunya:

32
Monocytes, Testes, Eye, Salivary gland, T cells, Skin, Liver, Brain

FMA organs/tissues related to Chikungunya:

14
Joint

Animal Models for Chikungunya or affiliated genes

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Publications for Chikungunya

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50PubMed
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Articles related to Chikungunya:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
A Novel Poxvirus-based Vaccine (MVA-CHIKV) is Highly Immunogenic and Protects Mice against Chikungunya Infection. (24403588)
2014
2
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. (23275491)
2013
3
Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation. (24126361)
2013
4
Production of recombinant Chikungunya virus envelope 2 protein in Escherichia coli. (24337252)
2013
5
Differential proteome analysis of chikungunya virus infection on host cells. (23593481)
2013
6
A Wolbachia wMel transinfection in Aedes albopictus is not detrimental to host fitness and inhibits Chikungunya virus. (23556030)
2013
7
Infection of Aedes albopictus with chikungunya virus rectally administered by enema. (23249139)
2013
8
Climate change effects on Chikungunya transmission in Europe: geospatial analysis of vector's climatic suitability and virus' temperature requirements. (24219507)
2013
9
Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library. (24205414)
2013
10
Infection of myofibers contributes to the increased pathogenicity during infection with an epidemic strain of Chikungunya Virus. (24335291)
2013
11
The threat of chikungunya in Oceania. (24015365)
2013
12
Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. (23350006)
2013
13
Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat? (23176378)
2013
14
A metapopulation model for chikungunya including populations mobility on a large-scale network. (23154189)
2013
15
Isolation of infectious chikungunya virus and dengue virus using anionic polymer-coated magnetic beads. (23669102)
2013
16
Surveillance for West Nile, dengue, and chikungunya virus infections, Veneto Region, Italy, 2010. (22469230)
2012
17
The cell biology of Chikungunya virus infection. (22686853)
2012
18
Optimal control of chikungunya disease: larvae reduction, treatment and prevention. (22901069)
2012
19
Production, characterization, and application of monoclonal antibodies specific to recombinant (E2) structural protein in antigen-capture ELISA for clinical diagnosis of Chikungunya virus. (22420756)
2012
20
Molecular investigations of chikungunya virus during outbreaks in Orissa, Eastern India in 2010. (22484761)
2012
21
pH-dependent entry of chikungunya virus into Aedes albopictus cells. (22386853)
2012
22
Construction of an infectious Chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites. (22673932)
2012
23
Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. (22833339)
2012
24
Chikungunya virus: host pathogen interaction. (21412934)
2011
25
Clinical Profile of Chikungunya Patients during the Epidemic of 2007 in Kerala, India. (21887052)
2011
26
Competitive suppression between chikungunya and dengue virus in Aedes albopictus c6/36 cell line. (22299407)
2011
27
Domestic and Environmental Factors of Chikungunya-affected Families in Thiruvananthapuram (Rural) District of Kerala, India. (21572606)
2011
28
Post-chikungunya chronic arthritis. (21751640)
2011
29
Rapid spread of chikungunya virus infection in Orissa: India. (21441687)
2011
30
Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff. (20962078)
2011
31
Apropos "chikungunya fever in the United States: a fifteen-year review of cases". (21498388)
2011
32
Evidence of acute rickettsioses among patients presumed to have chikungunya fever during the chikungunya outbreak in Sri Lanka. (22019568)
2011
33
Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses. (20881210)
2011
34
Prevalence of malaria, dengue, and chikungunya significantly associated with mosquito breeding sites. (23610486)
2011
35
Phylogeny and homologous recombination in Chikungunya viruses. (21925290)
2011
36
Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study. (21235760)
2011
37
Tracing the path of Chikungunya virus--evolution and adaptation. (20654736)
2010
38
An approach towards peptide-based antibody detection for diagnosis of Chikungunya infection. (20550431)
2010
39
Field evaluation of clinical features during chikungunya outbreak in Mayotte, 2005-2006. (20214759)
2010
40
Evaluation of a rapid assay for detection of IgM antibodies to chikungunya. (20578487)
2010
41
Differential protein modulation in midguts of Aedes aegypti infected with chikungunya and dengue 2 viruses. (20957153)
2010
42
Association of ABO blood groups with Chikungunya virus. (20579367)
2010
43
Development of a quantitative competitive reverse transcription polymerase chain reaction (QC-RT-PCR) for detection and quantitation of Chikungunya virus. (20054667)
2010
44
Wolbachia modulates Chikungunya replication in Aedes albopictus. (20345686)
2010
45
Molecular characterization of Chikungunya virus during an outbreak in South India. (20966558)
2010
46
Clinical features and epidemiology of chikungunya infection in Singapore. (19710977)
2009
47
Chikungunya Fever - epidemic in rural maharashtra. (20165644)
2009
48
Recently introduced Aedes albopictus in Corsica is competent to Chikungunya virus and in a lesser extent to dengue virus. (19725926)
2009
49
IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity. (19156204)
2009
50
Bilateral macular choroiditis following Chikungunya virus infection. (17479113)
2007

Genetic Variations for Chikungunya

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Expression for genes affiliated with Chikungunya

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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29KEGG
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Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6OAS3, FURIN, RSAD2, MAVS, C1QBP

Compounds for genes affiliated with Chikungunya

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44Novoseek, 24HMDB
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Compounds related to Chikungunya according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine449.6MAP3K14, MIF, ABCB7, FURIN, MT-ND5
2zinc44 2410.2FURIN, ABCB7, MIF, SH2D3A, C1QBP

GO Terms for genes affiliated with Chikungunya

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16Gene Ontology
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Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.3OAS3, IFI44L, PHB, DDX60, SH2D3C, MAP3K14

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral genome replicationGO:0450719.9MAVS, RSAD2, OAS3
2response to virusGO:0096159.9OAS3, RSAD2, DDX60
3defense response to virusGO:0516079.5OAS3, RSAD2, MAVS, DDX60, IFI44L
4innate immune responseGO:0450879.1C1QBP, DDX60, MAVS, MIF, RSAD2

Products for genes affiliated with Chikungunya

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chikungunya

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet