CK
MCID: CHK001
MIFTS: 50

Chikungunya (CK) malady

Genetic diseases, Rare diseases, Infectious diseases, Neuronal diseases, Fetal diseases, Bone diseases categories

Summaries for Chikungunya

About this section
Sources:
9Disease Ontology, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
CDC:4 Click here to view a Digital Press Kit on chikungunya from the CDC News Room. Chikungunya (pronunciation: \chik-en-gun-ye click to hear pronunciation) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

MalaCards: Chikungunya, also known as chikungunya virus infection, is related to myocardial infarction and acute myocardial infarction, and has symptoms including arthralgia, maculopapular rash and fever. An important gene associated with Chikungunya is NSDHL (NAD(P) dependent steroid dehydrogenase-like), and among its related pathways are Influenza A and Hepatitis C. Affiliated tissues include joint, monocytes and testes, and related mouse phenotype cardiovascular system.

Disease Ontology:9 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia:66 Chikungunya (English pronunciation: /?t??k?n?g???/ CHI-k?n-GUUN-y?; Makonde for \"that which bends up\")... more...

Description from OMIM:48 300831

Aliases & Classifications for Chikungunya

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 21GeneTests, 48OMIM, 11DISEASES, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

50
ck syndrome:
Inheritance: X-linked recessive; Prevalence: <1/1000000; Age of onset: Neonatal/infancy
chikungunya:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

chikungunya 9 44 11 50
chikungunya virus infection 44 63
chikungunya fever 9 44
ck syndrome 48 50
ck 44 21
x-linked intellectual disability - microcephaly - cortical malformation - thin habitus 50
arbovirus a chikungunya type 44
chikv infection 44
chik 44


External Ids:

Disease Ontology9 DOID:0050012
OMIM48 300831
ICD10 via Orphanet27 A92.0
ICD1026 A92.0

Related Diseases for Chikungunya

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Symptoms for Chikungunya

About this section
Sources:
48OMIM, 9Disease Ontology
See all sources

Symptoms by clinical synopsis from OMIM:

300831

Clinical features from OMIM:

300831

Symptoms:

9
  • arthralgia
  • maculopapular rash
  • fever

Drugs & Therapeutics for Chikungunya

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Chikungunya

Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Search CenterWatch for Chikungunya

Genetic Tests for Chikungunya

About this section
Sources:
21GeneTests
See all sources

Genetic tests related to Chikungunya:

id Genetic test Affiliating Genes
1 Ck Syndrome21

Anatomical Context for Chikungunya

About this section
Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Chikungunya:

34
Monocytes, Testes, Salivary gland, Eye, T cells, Skin, Liver, Brain

FMA organs/tissues related to Chikungunya:

15
Joint

Animal Models for Chikungunya or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Chikungunya:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7MAVS, NSDHL, ABCB7

Publications for Chikungunya

About this section
Sources:
53PubMed
See all sources

Articles related to Chikungunya:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Genomes to hits in silico - a country path today, a highway tomorrow: a case study of chikungunya. (23260020)
2013
2
Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces. (24009512)
2013
3
Development of a high-throughput antiviral assay for screening inhibitors of chikungunya virus and generation of drug-resistant mutations in cultured cells. (23821286)
2013
4
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. (23275491)
2013
5
Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. (24129946)
2013
6
Outbreak of chikungunya virus infection, Vanimo, Papua New Guinea. (23965757)
2013
7
Travel-Associated Chikungunya Cases in South Korea during 2009-2010. (24159550)
2013
8
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. (23936572)
2013
9
Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation. (24126361)
2013
10
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. (23864632)
2013
11
Chikungunya virus infection, Brazzaville, Republic of Congo, 2011. (23968609)
2013
12
Travelers as sentinels for chikungunya fever, Brazil. (22377013)
2012
13
High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand. (22188545)
2012
14
Chikungunya myeloradiculopathy: a rare complication. (23326078)
2012
15
Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae). (21750871)
2012
16
Chikungunya virus infection of corneal grafts. (22706183)
2012
17
Differential diagnosis of Chikungunya, dengue viral infection and other acute febrile illnesses in children. (22301475)
2012
18
Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. (22837213)
2012
19
Coinfection with dengue and chikungunya--a case report. (23738415)
2012
20
Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus. (22546647)
2012
21
Chikungunya virus-induced autophagy delays caspase-dependent cell death. (22508836)
2012
22
NMR structure, localization, and vesicle fusion of Chikungunya virus fusion peptide. (22978677)
2012
23
Prevalence of chikungunya in urban field practice area of a private medical college, chennai. (21976797)
2011
24
Isolation and molecular characterization of Chikungunya virus from the Andaman and Nicobar archipelago, India: evidence of an East, Central, and South African genotype. (22136155)
2011
25
Chikungunya virus: host pathogen interaction. (21412934)
2011
26
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. (21811589)
2011
27
Chikungunya epidemic-related mortality. (21073766)
2011
28
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. (22014740)
2011
29
Clinical Profile of Chikungunya Patients during the Epidemic of 2007 in Kerala, India. (21887052)
2011
30
Competitive suppression between chikungunya and dengue virus in Aedes albopictus c6/36 cell line. (22299407)
2011
31
Exposure to chikungunya virus and adult longevity in Aedes aegypti (L.) and Aedes albopictus (Skuse). (20618649)
2010
32
Different lineages of Chikungunya virus in Equatorial Guinea in 2002 and 2006. (20207882)
2010
33
Urological manifestations of Chikungunya fever: A single centre experience. (20981198)
2010
34
Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus. (19725768)
2010
35
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. (20952847)
2010
36
CHIKVPRO - a protein sequence annotation database for chikungunya virus. (21346870)
2010
37
First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality! (21040155)
2010
38
Reemergence of Chikungunya virus in Indian Subcontinent. (23637474)
2010
39
Tracing the path of Chikungunya virus--evolution and adaptation. (20654736)
2010
40
Chikungunya virus infection during pregnancy, Reunion, France, 2006. (20202416)
2010
41
Suppressing Aedes albopictus, an emerging vector of dengue and chikungunya viruses, by a novel combination of a monomolecular film and an insect-growth regulator. (20439963)
2010
42
Breeding potential of Aedes albopictus (Skuse, 1895) in chikungunya affected areas of Kerala, India. (21245624)
2010
43
Whole-genome characterisation of Chikungunya virus from Aedes albopictus collected in Thailand. (20507700)
2010
44
Chikungunya: an emerging and spreading arthropod-borne viral disease. (20009275)
2009
45
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak. (19857273)
2009
46
A suspicion of chikungunya leading to a diagnosis of angioimmunoblastic T-cell lymphoma. (19173091)
2009
47
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. (20003320)
2009
48
Immuno-biology of Chikungunya and implications for disease intervention. (19737625)
2009
49
Chikungunya virus isolated from a returnee to Japan from Sri Lanka: isolation of two sub-strains with different characteristics. (19861623)
2009
50
Sporadic cases of chikungunya, RAcunion Island, August 2009. (19728980)
2009

Variations for Chikungunya

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Chikungunya:

1
id Gene Name Type Significance SNP ID Assembly Location
1NSDHLNM_001129765.1(NSDHL): c.1098dupT (p.Arg367Serfs)duplicationPathogenicrs121909834GRCh37Chr X, 152037636: 152037637
2NSDHLNM_001129765.1(NSDHL): c.696_698delGAA (p.Lys232del)deletionPathogenicrs121909833GRCh37Chr X, 152036124: 152036126

Expression for genes affiliated with Chikungunya

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

About this section
Sources:
51PathCards, 31KEGG
See all sources

Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1MAVS, OAS3
29.1MAVS, OAS3

Compounds for genes affiliated with Chikungunya

About this section

GO Terms for genes affiliated with Chikungunya

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.5NSDHL, OAS3

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.1MAVS, OAS3
2negative regulation of viral genome replicationGO:0450718.8MAVS, OAS3

Products for genes affiliated with Chikungunya

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chikungunya

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet