CHIK
MCID: CHK001
MIFTS: 48

Chikungunya (CHIK) malady

Infectious diseases category

Summaries for Chikungunya

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Chikungunya (pronunciation: \chik-en-gun-ye click to hear pronunciation) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. Chikungunya virus is not currently found in the United States. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

MalaCards: Chikungunya, also known as chikungunya virus infection, is related to yellow fever and venezuelan equine encephalitis, and has symptoms including maculopapular rash, arthralgia and fever. An important gene associated with Chikungunya is MT-ND5 (mitochondrially encoded NADH dehydrogenase 5), and among its related pathways is Influenza A. The compounds alanine and zinc have been mentioned in the context of this disorder. Affiliated tissues include joint, monocytes and testes.

Disease Ontology:8 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia:63 Chikungunya (in the Makonde language \"that which bends up\") virus (CHIKV) is an arthropod-borne virus,... more...

Aliases & Classifications for Chikungunya

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
chikungunya:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

chikungunya 8 42 10 48
chikungunya virus infection 42 60
chikungunya fever 8 42
arbovirus a chikungunya type 42
chikv infection 42
chik 42


External Ids:

Disease Ontology8 DOID:0050012
ICD10 via Orphanet26 A92.0
ICD1025 A92.0

Related Diseases for Chikungunya

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Clinical Features for Chikungunya

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8Disease Ontology
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Symptoms:

8
  • maculopapular rash
  • arthralgia
  • fever

Drugs & Therapeutics for Chikungunya

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chikungunya

Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Search CenterWatch for Chikungunya

Genetic Tests for Chikungunya

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Anatomical Context for Chikungunya

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Chikungunya:

32
Monocytes, Testes, Salivary gland, Eye, T cells, Brain, Liver, Skin

FMA organs/tissues related to Chikungunya:

14
Joint

Animal Models for Chikungunya or affiliated genes

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Publications for Chikungunya

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50PubMed
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Articles related to Chikungunya:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Analysis of antibody response (IgM, IgG, IgG3) to Chikungunya virus using panel of peptides derived from envelope protein for serodiagnosis. (24088615)
2014
2
Antibody Kinetics in Infants Exposed to Chikungunya Virus Infection During Pregnancy Reveals Absence of Congenital Infection. (24338351)
2014
3
Travel-Associated Chikungunya Cases in South Korea during 2009-2010. (24159550)
2013
4
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. (23864632)
2013
5
Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy. (23811281)
2013
6
Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response. (24131709)
2013
7
The role of environmental variables on Aedes albopictus biology and chikungunya epidemiology. (23916332)
2013
8
High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand. (22188545)
2012
9
Chikungunya virus infection of corneal grafts. (22706183)
2012
10
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication. (23215460)
2012
11
Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study. (22496701)
2012
12
Rapid spread of chikungunya virus following its resurgence during 2006 in West Bengal, India. (22265077)
2012
13
An outbreak of chikungunya in Jamshedpur, Jharkhand in 2011. (23287142)
2012
14
Inactivation of Chikungunya virus by 1,5 iodonapthyl azide. (23210745)
2012
15
Cell-based analysis of Chikungunya virus E1 protein in membrane fusion. (22520648)
2012
16
Viperin restricts chikungunya virus replication and pathology. (23160199)
2012
17
Mapping interactions of Chikungunya virus nonstructural proteins. (22951312)
2012
18
Evaluation of two IgM rapid immunochromatographic tests during circulation of Asian lineage Chikungunya virus. (23082554)
2012
19
Detection of Chikungunya virus in wild populations of Aedes albopictus in Kerala State, India. (22925018)
2012
20
Maiden outbreak of chikungunya in Dongguan city, Guangdong province, China: epidemiological characteristics. (22916166)
2012
21
A case of bilateral Chikungunya neuroretinitis. (21881835)
2012
22
Mouse macrophage innate immune response to Chikungunya virus infection. (23253140)
2012
23
Transmission potential of two chimeric Chikungunya vaccine candidates in the urban mosquito vectors, Aedes aegypti and Ae. albopictus. (21633043)
2011
24
Outbreak of Chikungunya in the Republic of Congo and the global picture. (21727642)
2011
25
ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. (22028657)
2011
26
Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes. (21518887)
2011
27
In vivo imaging of chikungunya virus in mice and Aedes mosquitoes using a Renilla luciferase clone. (21668347)
2011
28
Cell-based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors. (21619896)
2011
29
Breeding potential of Aedes albopictus (Skuse, 1895) in chikungunya affected areas of Kerala, India. (21245624)
2010
30
Chikungunya: a potentially emerging epidemic? (20436958)
2010
31
Entire genome characterization of Chikungunya virus from the 2008-2009 outbreaks in Thailand. (20962712)
2010
32
Chikungunya virus arthritis in adult wild-type mice. (20519386)
2010
33
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. (20686047)
2010
34
Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore. (19955565)
2010
35
Chikungunya rash. (20431165)
2010
36
Chikungunya and dengue virus antibodies in a traveller with severe arthralgia returning from India. (20646955)
2010
37
Mucocutaneous manifestations of Chikungunya fever. (20418982)
2010
38
Detection of viral antigen, IgM and IgG antibodies in cerebrospinal fluid of Chikungunya patients with neurological complications. (20704763)
2010
39
Chikungunya. (20513548)
2010
40
Broad reactive monoclonal antibodies for rapid identification of enteroviruses show cross-reactivity with chikungunya virus infected cells. (20614726)
2010
41
Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. (20404274)
2010
42
Molecular insight into the specific binding of ADP-ribose to the nsP3 macro domains of chikungunya and Venezuelan equine encephalitis viruses: molecular dynamics simulations and free energy calculations. (21036084)
2010
43
Chikungunya: an emerging and spreading arthropod-borne viral disease. (20009275)
2009
44
Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunya. (19748424)
2009
45
Focus on Chikungunya pathophysiology in human and animal models. (19737626)
2009
46
The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus. (19056102)
2009
47
A report of 21 cases of rheumatoid arthritis following Chikungunya fever. A mean follow-up of two years. (19945329)
2009
48
A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium. (20064373)
2009
49
Outbreak of chikungunya in Johor Bahru, Malaysia: clinical and laboratory features of hospitalized patients. (20527272)
2009
50
Chikungunya, an epidemic arbovirosis. (17448935)
2007

Genetic Variations for Chikungunya

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Expression for genes affiliated with Chikungunya

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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29KEGG
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Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6OAS3, FURIN, RSAD2, MAVS, C1QBP

Compounds for genes affiliated with Chikungunya

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44Novoseek, 24HMDB
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Compounds related to Chikungunya according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine449.6MT-ND5, MAP3K14, MIF, ABCB7, FURIN
2zinc44 2410.2C1QBP, SH2D3A, MIF, ABCB7, FURIN

GO Terms for genes affiliated with Chikungunya

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16Gene Ontology
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Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.3OAS3, IFI44L, PHB, DDX60, SH2D3C, MAP3K14

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral genome replicationGO:0450719.9OAS3, RSAD2, MAVS
2response to virusGO:0096159.9DDX60, RSAD2, OAS3
3defense response to virusGO:0516079.5IFI44L, DDX60, MAVS, RSAD2, OAS3
4innate immune responseGO:0450879.1C1QBP, DDX60, MAVS, MIF, RSAD2

Products for genes affiliated with Chikungunya

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chikungunya

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet