CHIK
MCID: CHK001
MIFTS: 48

Chikungunya (CHIK) malady

Infectious diseases category

Summaries for Chikungunya

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Chikungunya (pronunciation: \chik-en-gun-ye click to hear pronunciation) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. Chikungunya virus is not currently found in the United States. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

MalaCards: Chikungunya, also known as chikungunya virus infection, is related to yellow fever and venezuelan equine encephalitis, and has symptoms including maculopapular rash, arthralgia and fever. An important gene associated with Chikungunya is MT-ND5 (mitochondrially encoded NADH dehydrogenase 5), and among its related pathways is Influenza A. The compounds alanine and zinc have been mentioned in the context of this disorder. Affiliated tissues include joint, monocytes and testes.

Disease Ontology:8 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

Wikipedia:63 Chikungunya (in the Makonde language \"that which bends up\") virus (CHIKV) is an arthropod-borne virus,... more...

Aliases & Classifications for Chikungunya

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
chikungunya:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

chikungunya 8 42 10 48
chikungunya virus infection 42 60
chikungunya fever 8 42
arbovirus a chikungunya type 42
chikv infection 42
chik 42


External Ids:

Disease Ontology8 DOID:0050012
ICD10 via Orphanet26 A92.0
ICD1025 A92.0

Related Diseases for Chikungunya

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Clinical Features for Chikungunya

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8Disease Ontology
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Symptoms:

8
  • maculopapular rash
  • arthralgia
  • fever

Drugs & Therapeutics for Chikungunya

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chikungunya

Drug clinical trials:

Search ClinicalTrials for Chikungunya

Search NIH Clinical Center for Chikungunya

Search CenterWatch for Chikungunya

Genetic Tests for Chikungunya

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Anatomical Context for Chikungunya

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Chikungunya:

32
Monocytes, Testes, Eye, Salivary gland, T cells, Skin, Liver, Brain

FMA organs/tissues related to Chikungunya:

14
Joint

Animal Models for Chikungunya or affiliated genes

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Publications for Chikungunya

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50PubMed
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Articles related to Chikungunya:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
An agent-based model driven by tropical rainfall to understand the spatio-temporal heterogeneity of a chikungunya outbreak. (23958228)
2014
2
Application of real-time RT-PCR in vector surveillance and assessment of replication kinetics of an emerging novel ECSA genotype of Chikungunya virus in Aedes aegypti. (23850695)
2013
3
HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India. (23710940)
2013
4
Development of rapid, sensitive one-tube duplex RT-PCR assay for specific and differential diagnosis of Chikungunya and dengue. (23896021)
2013
5
A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2. (22983165)
2013
6
An essential role of antibodies in the control of Chikungunya virus infection. (23670192)
2013
7
Characterization of the Complete Genome of Chikungunya in Zhejiang, China, Using a Modified Virus Discovery Method Based on cDNA-AFLP. (24367579)
2013
8
Underdiagnosis of chikungunya virus infections in symptomatic dutch travelers returning from the Indian ocean area. (23279230)
2013
9
A new challenge for hospitals in southeast France: monitoring local populations of Aedes albopictus to prevent nosocomial transmission of dengue or chikungunya. (23687863)
2013
10
Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae). (21750871)
2012
11
Chikungunya virus-induced autophagy delays caspase-dependent cell death. (22508836)
2012
12
Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against chikungunya virus. (22884660)
2012
13
Chikungunya outbreak in Guangdong Province, China, 2010. (22377135)
2012
14
Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology. (22418724)
2012
15
Deciphering the differential response of two human fibroblast cell lines following Chikungunya virus infection. (22992396)
2012
16
Chikungunya fever. (22560378)
2012
17
Mathematical studies on the sterile insect technique for the Chikungunya disease and Aedes albopictus. (22038083)
2012
18
A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. (22647698)
2012
19
Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. (22670036)
2012
20
Aedes albopictus (Diptera: Culicidae) population size survey in the 2007 chikungunya outbreak area in Italy. II: Estimating epidemic thresholds. (22493859)
2012
21
Genetic diversity of Chikungunya virus, India 2006-2010: evolutionary dynamics and serotype analyses. (22246833)
2012
22
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock. (22761364)
2012
23
Molecular epidemiology of Chikungunya virus: mutation in E1 gene region. (22782121)
2012
24
The first dominant co-circulation of both dengue and chikungunya viruses during the post-monsoon period of 2010 in Delhi, India. (21906409)
2012
25
Expression of plasmid-based shRNA against the E1 and nsP1 genes effectively silenced Chikungunya virus replication. (23056297)
2012
26
Prevalence of chikungunya in urban field practice area of a private medical college, chennai. (21976797)
2011
27
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. (21811589)
2011
28
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. (22014740)
2011
29
Differential proteome analysis of Chikungunya virus-infected new-born mice tissues reveal implication of stress, inflammatory and apoptotic pathways in disease pathogenesis. (21472854)
2011
30
Chikungunya fever: focus on peripheral markers of pathogenesis. (21288810)
2011
31
Treatment practices & laboratory investigations during chikungunya outbreaks in South India. (21623042)
2011
32
Impact of Chikungunya virus infection on oral health status: an observational study. (22124070)
2011
33
Surveillance of the chikungunya vector Aedes albopictus (Skuse) in Emilia-Romagna (northern Italy): organizational and technical aspects of a large scale monitoring system. (21635648)
2011
34
Chikungunya virus outbreak in Kerala, India, 2007: a seroprevalence study. (22241110)
2011
35
Utility of multiplex reverse transcriptase-polymerase chain reaction for diagnosis and serotypic characterization of dengue and chikungunya viruses in clinical samples. (21865001)
2011
36
Chikungunya virus infection during pregnancy, Reunion, France, 2006. (20202416)
2010
37
Diagnosis and management of imported Chikungunya fever in Taiwan: a case report. (20466336)
2010
38
Serum IL-18 and IL-18BP levels in patients with Chikungunya virus infection. (20121409)
2010
39
HLA class I restriction as a possible driving force for Chikungunya evolution. (20195467)
2010
40
Vector competence of Florida mosquitoes for chikungunya virus. (21175954)
2010
41
Chikungunya fever from Malaysia. (20190493)
2010
42
Outbreak of chikungunya fever, Dakshina Kannada District, South India, 2008. (20889860)
2010
43
Sporadic cases of chikungunya, RAcunion Island, August 2009. (19728980)
2009
44
Assessing the risk of importing dengue and chikungunya viruses to the European Union. (21352765)
2009
45
Replication cycle of chikungunya: a re-emerging arbovirus. (19732931)
2009
46
Impact of Chikungunya virus infection on health status and quality of life: a retrospective cohort study. (19911058)
2009
47
Investigations on possible role of MIF gene polymorphism in progression of chikungunya infection into cases of acute flaccid paralysis and chronic arthropathy. (19417556)
2009
48
Acute myocarditis due to Chikungunya virus assessed by contrast-enhanced MRI. (17692962)
2007
49
Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. (16700631)
2006
50
Chikungunya fever as a risk factor for endemic Burkitt's lymphoma in Malawi. (11198662)
2000

Genetic Variations for Chikungunya

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Expression for genes affiliated with Chikungunya

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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29KEGG
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Pathways related to Chikungunya according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6OAS3, FURIN, RSAD2, MAVS, C1QBP

Compounds for genes affiliated with Chikungunya

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44Novoseek, 24HMDB
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Compounds related to Chikungunya according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine449.6MAP3K14, MIF, ABCB7, FURIN, MT-ND5
2zinc44 2410.2FURIN, ABCB7, MIF, SH2D3A, C1QBP

GO Terms for genes affiliated with Chikungunya

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16Gene Ontology
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Cellular components related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.3OAS3, IFI44L, PHB, DDX60, SH2D3C, MAP3K14

Biological processes related to Chikungunya according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral genome replicationGO:0450719.9MAVS, RSAD2, OAS3
2response to virusGO:0096159.9OAS3, RSAD2, DDX60
3defense response to virusGO:0516079.5OAS3, RSAD2, MAVS, DDX60, IFI44L
4innate immune responseGO:0450879.1C1QBP, DDX60, MAVS, MIF, RSAD2

Products for genes affiliated with Chikungunya

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chikungunya

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet