MCID: CHK001
MIFTS: 61

Chikungunya

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 72 49 55 40 14
Chikungunya Fever 12 49 3 69
Ck 49 3
Arbovirus a Chikungunya Type 49
Chikungunya Virus Infection 49
Chikv Infection 49
Chik 49

Characteristics:

Orphanet epidemiological data:

55
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
Orphanet 55 ORPHA324625
UMLS via Orphanet 70 C0008055
ICD10 via Orphanet 33 A92.0
ICD10 32 A92.0
UMLS 69 C0008055

Summaries for Chikungunya

MedlinePlus : 40 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to dengue virus and encephalitis, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs chloroquine and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results_in infection located in joint, has material basis in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Chikungunya (pronunciation: chik-en-gun-ye) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

Wikipedia : 72 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 dengue virus 32.4 DDX58 OAS3 RSAD2
2 encephalitis 29.7 CCL5 DDX58 IL1B RSAD2
3 japanese encephalitis 29.7 CCL5 DDX58 TNF
4 myocarditis 29.6 CD40LG IL6 TNF
5 neuritis 29.6 CCL5 IL1B TNF
6 arthritis 29.5 IL18 IL1B IL6 TNF
7 hemorrhagic fever 29.5 CD40LG IL6 TNF
8 myocardial infarction 29.5 CCL5 CD40LG IL1B IL6 TNF
9 rheumatic disease 29.4 CD40LG IL1B TNF
10 anterior uveitis 29.4 IL6 TNF
11 meningoencephalitis 29.4 CCL5 CD40LG IL6
12 leptospirosis 29.2 CD40LG IL1B IL6 TNF
13 stomatitis 29.1 BST2 DDX58 IL1B RSAD2
14 malaria 28.0 CCL5 CD40LG IL18 IL1B IL6 TNF
15 rheumatoid arthritis 27.9 CCL5 CD40LG IL18 IL1B IL6 TNF
16 psoriasis 27.7 CCL5 DDX58 IL18 IL1B IL6 TNF
17 asthma 27.5 CCL5 CD40LG IL18 IL1B IL6 TNF
18 systemic lupus erythematosus 27.5 CCL5 CD40LG IL18 IL1B IL6 TNF
19 ck syndrome 12.5
20 isolated hyperckemia 10.9
21 chylomicron retention disease 10.9
22 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.9
23 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency 10.9
24 myopathy, vacuolar, with casq1 aggregates 10.9
25 phosphoglycerate mutase deficiency 10.9
26 welander distal myopathy, swedish type 10.9
27 west nile encephalitis 10.4 BST2 OAS3
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
29 critical limb ischemia 10.4 IL6 TNF
30 streptococcal toxic-shock syndrome 10.4 IL6 TNF
31 null-cell leukemia 10.3 IL6 TNF
32 acute myocardial infarction 10.3
33 obesity-hypoventilation syndrome 10.3 CCL5 IL6
34 polyposis, gastric 10.3 IL1B TNF
35 retinitis pigmentosa 55 10.3 IL6 TNF
36 recurrent corneal erosion 10.3 IL1B IL6
37 bagassosis 10.3 IL1B IL6
38 staphylococcal toxic shock syndrome 10.2 IL1B TNF
39 periodontitis, chronic 10.2 IL1B IL6
40 kashin-beck disease 10.2 IL1B TNF
41 glossitis 10.2 IL6 TNF
42 trench fever 10.2 CD40LG TNF
43 encephalitozoonosis 10.2 CD40LG TNF
44 rheumatoid lung disease 10.2 CD40LG TNF
45 miller fisher syndrome 10.2 CD40LG TNF
46 vulvar vestibulitis syndrome 10.2 IL1B TNF
47 scorpion envenomation 10.2 CCL5 IL6 TNF
48 avian influenza 10.2 DDX58 IL6 TNF
49 polyclonal hypergammaglobulinemia 10.2 CD40LG IL6
50 filariasis 10.1 CCL5 IL6 TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


pruritus, fever

MGI Mouse Phenotypes related to Chikungunya:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CCL5 NDST1 CD40LG DDX58 RSAD2 TLR8
2 homeostasis/metabolism MP:0005376 9.9 MAVS NDST1 CD40LG PHB DDX58 RSAD2
3 digestive/alimentary MP:0005381 9.8 MAVS NDST1 DDX58 IL18 TNF IL6
4 immune system MP:0005387 9.7 CCL5 NDST1 CD40LG DDX58 RSAD2 TLR8
5 integument MP:0010771 9.17 MAVS CD40LG PHB IL18 TNF IL1B

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Anti-Inflammatory Agents Phase 3
3 Anti-Inflammatory Agents, Non-Steroidal Phase 3
4 Antirheumatic Agents Phase 3
5 Chloroquine diphosphate Phase 3 50-63-5
6 Analgesics Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Anthelmintics Phase 3
9 Peripheral Nervous System Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Antimalarials Phase 3
12 Antiprotozoal Agents Phase 3
13 Antiparasitic Agents Phase 3
14 Rho(D) Immune Globulin Phase 1, Phase 2
15 gamma-Globulins Phase 1, Phase 2
16 Immunoglobulins Phase 1, Phase 2
17 Immunoglobulins, Intravenous Phase 1, Phase 2
18 Antibodies Phase 1, Phase 2
19 Vaccines Phase 2,Phase 1
20 Pharmaceutical Solutions Phase 2
21
Mechlorethamine Approved, Investigational 51-75-2 4033
22
Methotrexate Approved 1959-05-2, 59-05-2 126941
23
Pantoprazole Approved 102625-70-7 4679
24
Prednisolone Approved, Vet_approved 50-24-8 5755
25
Methylprednisolone Approved, Vet_approved 83-43-2 6741
26
leucovorin Approved, Nutraceutical 58-05-9 143 6006
27
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
28 Prednisolone acetate
29 Methylprednisolone acetate
30 Methylprednisolone Hemisuccinate
31 Folic Acid Antagonists
32 Nucleic Acid Synthesis Inhibitors
33 Dermatologic Agents
34 Vitamin B Complex
35 Prednisolone hemisuccinate
36 Immunosuppressive Agents
37 Prednisolone phosphate
38 Antimetabolites
39 Antimetabolites, Antineoplastic
40 Folate Nutraceutical
41 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3 Chloroquine
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Recruiting NCT03101111 Phase 2
5 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Active, not recruiting NCT02861586 Phase 2
6 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Active, not recruiting NCT02562482 Phase 2
7 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
8 Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Subjects Recruiting NCT03325075 Phase 1
9 Phase I Trial of Measles Vectored Chikungungya Vaccine Recruiting NCT03028441 Phase 1
10 Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Not yet recruiting NCT03382964 Phase 1
11 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
12 Chikungunya Arthritis in the Americas Completed NCT02463968
13 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685
14 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
15 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952
16 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
17 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
18 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
19 Zika and Microcephaly: Case-control Study Completed NCT02741882
20 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Recruiting NCT02174341
21 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Recruiting NCT02901509
22 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Recruiting NCT02831699
23 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
24 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
25 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
26 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363
27 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
28 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
29 Non Randomized Comparative Study With Control Recruiting NCT03294824
30 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
31 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444
32 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
33 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Active, not recruiting NCT03058471 Methotrexate;NSAID;Steroids
34 Applying Wolbachia to Eliminate Dengue Not yet recruiting NCT03055585
35 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
36 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Suspended NCT02714985

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

18
Joint

MalaCards organs/tissues related to Chikungunya:

38
Testes, Heart, Monocytes, T Cells, Bone, Brain, Salivary Gland

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 707)
# Title Authors Year
1
Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones. ( 29406692 )
2018
2
Clinical Profile, Intensive Care Unit Course, and Outcome of Patients Admitted in Intensive Care Unit with Chikungunya. ( 29422725 )
2018
3
Anti-viral Activities of<i>Oroxylum indicum</i>Extracts on Chikungunya Virus Infection. ( 29434399 )
2018
4
Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community. ( 29410416 )
2018
5
Case Report: An Acute Chikungunya Infection and a Recent Secondary Dengue Infection in a Peripartum Case in Ecuador. ( 29363451 )
2018
6
An Assessment of Household and Individual-Level Mosquito Prevention Methods during the Chikungunya Virus Outbreak in the United States Virgin Islands, 2014-2015. ( 29405105 )
2018
7
Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases. ( 29435366 )
2018
8
Emergence and treatment of chikungunya arthritis. ( 29389830 )
2018
9
Acute inflammatory arthritis: Methotrexate for chronic chikungunya arthritis? ( 29416137 )
2018
10
Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity. ( 29382880 )
2018
11
A summary of the imported cases of Chikungunya fever in Japan from 2006 to June 2016. ( 29394382 )
2018
12
Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil. ( 29404420 )
2018
13
Co-circulation and simultaneous co-infection of dengue, chikungunya, and zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border. ( 29382300 )
2018
14
Chikungunya: A rheumatologist's perspective. ( 29431292 )
2018
15
The Burden of Chikungunya Virus Infection: The Need for Systematic and Geriatric-Specific Epidemiological Monitoring. ( 29437206 )
2018
16
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. ( 29415070 )
2018
17
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. ( 29432457 )
2018
18
Effect of Chikungunya Virus Infection on Individuals and the Healthcare System. ( 29437205 )
2018
19
Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations. ( 29425199 )
2018
20
Spread of Chikungunya Virus East/Central/South African Genotype in Northeast Brazil. ( 28930031 )
2017
21
Long-term Chikungunya Sequelae in CuraAsao: Burden, Determinants, and a Novel Classification Tool. ( 28931219 )
2017
22
Clinical Spectrum of Chikungunya in Pakistan. ( 28924518 )
2017
23
Toxicity of ar-curcumene and epi-I^-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors. ( 27918946 )
2017
24
Third cranial nerve palsy and Chikungunya virus infection. ( 29271691 )
2017
25
Chikungunya Virus-Induced Arthritis: Role of Host and Viral Factors in the Pathogenesis. ( 28910194 )
2017
26
Chikungunya Virus Infection: Why Should U.S. Geriatricians Be Aware of It? ( 28940385 )
2017
27
Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain. ( 28077641 )
2017
28
Third Cranial Nerve Palsy after a Chikungunya Virus Infection. ( 29135313 )
2017
29
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection. ( 28404855 )
2017
30
Chikungunya Fever Presenting as Life Threatening Thrombotic Thrombocytopenic Purpura. ( 28792176 )
2017
31
Fever, marked tachycardia and vesiculobullous rash in an infant with Chikungunya fever. ( 28942395 )
2017
32
Post-Chikungunya Rheumatic Disease in a 13-Year-Old Boy. ( 28884916 )
2017
33
Atypical Clinical Presentations of Acute Phase Chikungunya Virus Infection in Older Adults. ( 28940357 )
2017
34
Association of toll-like receptor polymorphisms with susceptibility to chikungunya virus infection. ( 28888110 )
2017
35
Chikungunya Infection in Hospitalized Febrile Infants Younger Than 3 Months of Age. ( 28060043 )
2017
36
Impaired NK cell functionality and increased TNF-I+ production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis. ( 28213049 )
2017
37
Chikungunya Virus Infection Associated with Encephalitis and Anterior Uveitis. ( 29020499 )
2017
38
At the advancing front of Chikungunya fever in Asia: Two imported cases in Hong Kong with novel amino acid changes. ( 28918988 )
2017
39
Image Gallery: Flagellate bullous exanthem in chikungunya. ( 29052889 )
2017
40
Chikungunya in Kidney Transplant Recipients. A series of cases. ( 28941631 )
2017
41
Concurrent Infection with Plasmodium vivax and the Dengue and Chikungunya Viruses in a Paediatric Patient from New Delhi, India in 2016. ( 28910810 )
2017
42
Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil. ( 28930027 )
2017
43
Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. ( 28067803 )
2017
44
Glutathionylation of chikungunya nsP2 protein affects protease activity. ( 27984114 )
2017
45
Genital Aphthous Ulcers and a Case of Suspected Chikungunya: A Short Clinical Case. ( 28915309 )
2017
46
Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus. ( 28942824 )
2017
47
Epidemic outbreak of Chikungunya in two neighboring towns in the Colombian Caribbean: a survival analysis. ( 28074128 )
2017
48
Do Two Screening Tools for Chikungunya Virus Infection that were Developed among Younger Population Work Equally as Well in Patients Aged over 65 Years? ( 28056031 )
2017
49
Sensitivity and detection of chikungunya viral genetic material using several PCR-based approaches. ( 28954066 )
2017
50
Chikungunya: A crippling virus hits Karachi, Sindh. ( 28924300 )
2017

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 BST2 CCL5 CD40LG DDX58 IL18 IL1B
2
Show member pathways
13.35 CCL5 CD40LG IL18 IL1B IL6 TLR8
3
Show member pathways
13.25 CCL5 CD40LG IL18 IL1B IL6 TNF
4
Show member pathways
13.11 BST2 CCL5 CD40LG DDX58 IL18 IL1B
5
Show member pathways
12.88 CCL5 IL18 IL1B IL6 MAVS OAS3
6
Show member pathways
12.67 CD40LG IL1B IL6 TLR8 TNF
7
Show member pathways
12.67 CCL5 DDX58 IL18 IL1B IL6 MAVS
8
Show member pathways
12.55 IL18 IL1B IL6 TNF
9
Show member pathways
12.54 IL18 IL1B IL6 TNF
10
Show member pathways
12.53 DDX58 IL6 MAVS TNF
11
Show member pathways
12.5 BST2 DDX58 OAS3 RSAD2
12
Show member pathways
12.5 CCL5 IL1B IL6 TLR8 TNF
13
Show member pathways
12.39 CD40LG IL1B IL6 TNF
14
Show member pathways
12.3 CCL5 IL1B IL6 TNF
15
Show member pathways
12.3 CCL5 DDX58 IL18 IL1B IL6 MAVS
16 12.27 CCL5 CD40LG DDX58 IL1B MAVS RSAD2
17 12.21 IL18 IL1B IL6 TNF
18
Show member pathways
12.16 IL1B IL6 TLR8 TNF
19 12.05 DDX58 MAVS OAS3 TNF
20 11.97 IL1B IL6 TNF
21 11.96 IL18 IL1B IL6 TNF
22 11.93 CCL5 IL1B IL6 TNF
23
Show member pathways
11.93 IL18 IL1B IL6 TLR8 TNF
24 11.87 IL1B IL6 TNF
25 11.86 IL1B IL6 TNF
26 11.85 IL1B IL6 TNF
27 11.85 CD40LG DDX58 IL1B TNF
28
Show member pathways
11.83 IL1B IL6 TLR8
29 11.83 CCL5 IL18 IL1B IL6 TNF
30 11.8 IL18 IL1B IL6
31 11.76 IL18 IL1B TNF
32 11.74 IL1B IL6 TNF
33 11.72 IL1B IL6 TNF
34 11.67 CCL5 IL1B IL6 TNF
35 11.66 CD40LG IL6 TNF
36
Show member pathways
11.66 CD40LG IL1B IL6 TNF
37 11.59 IL18 IL1B IL6 TNF
38 11.51 IL18 IL1B TNF
39 11.48 IL1B IL6 TNF
40 11.46 CCL5 IL18 IL1B IL6 TNF
41 11.41 CD40LG IL18 IL1B IL6 TNF
42 11.38 IL18 IL1B IL6 TNF
43
Show member pathways
11.38 BST2 IL18 IL1B IL6 OAS3 RSAD2
44 11.36 IL1B IL6 TNF
45 11.35 CCL5 IL1B IL6
46 11.33 IL18 IL1B IL6 TNF
47 11.29 IL1B IL6 TNF
48 11.27 IL1B IL6 TNF
49 11.11 CCL5 CD40LG IL18 IL1B IL6 TNF
50 11.1 IL18 IL1B TNF

GO Terms for Chikungunya

Cellular components related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL5 CD40LG IL18 IL1B IL6 OAS3

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 CCL5 IL18 IL1B TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 BST2 IL1B MAVS TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG IL1B IL6 TNF
4 inflammatory response GO:0006954 9.86 CCL5 CD40LG IL18 IL1B IL6 NDST1
5 regulation of insulin secretion GO:0050796 9.85 CCL5 IL1B TNF
6 cellular response to organic cyclic compound GO:0071407 9.85 CCL5 IL18 IL1B TNF
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 CCL5 IL18 IL6
8 type I interferon signaling pathway GO:0060337 9.83 BST2 OAS3 RSAD2
9 positive regulation of T cell proliferation GO:0042102 9.83 CCL5 CD40LG IL1B IL6
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 DDX58 IL1B IL6 MAVS TNF
11 humoral immune response GO:0006959 9.81 BST2 IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 CCL5 IL18 IL6 TNF
13 protein kinase B signaling GO:0043491 9.79 CCL5 IL1B TNF
14 positive regulation of interleukin-6 production GO:0032755 9.78 DDX58 IL1B IL6 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL1B TNF
16 positive regulation of NF-kappaB import into nucleus GO:0042346 9.74 IL18 IL1B TNF
17 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
18 positive regulation of JAK-STAT cascade GO:0046427 9.71 CCL5 IL6
19 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
20 positive regulation of transcription factor import into nucleus GO:0042993 9.71 DDX58 MAVS
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
22 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 MAVS
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL5 IL18 IL1B TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
26 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 MAVS
27 defense response to virus GO:0051607 9.7 BST2 DDX58 IL6 MAVS OAS3 RSAD2
28 neutrophil activation GO:0042119 9.69 CCL5 IL18
29 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
30 positive regulation of tumor necrosis factor secretion GO:1904469 9.68 DDX58 MAVS
31 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR8 TNF
33 positive regulation of interferon-alpha secretion GO:1902741 9.67 DDX58 MAVS
34 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 DDX58 IL18 IL1B
35 positive regulation of interleukin-8 production GO:0032757 9.67 DDX58 IL1B MAVS TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
37 interleukin-6 production GO:0032635 9.66 IL18 IL1B
38 positive regulation of response to cytokine stimulus GO:0060760 9.65 DDX58 MAVS
39 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.64 IL6 RSAD2
40 positive regulation of interferon-beta secretion GO:0035549 9.63 DDX58 MAVS
41 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
42 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
43 positive regulation of interleukin-6 secretion GO:2000778 9.62 DDX58 IL1B MAVS TLR8
44 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 IL1B TNF
46 response to virus GO:0009615 9.5 BST2 CCL5 DDX58 OAS3 RSAD2 TLR8
47 negative regulation of viral genome replication GO:0045071 9.1 BST2 CCL5 MAVS OAS3 RSAD2 TNF
48 positive regulation of transcription by RNA polymerase II GO:0045944 10.17 DDX58 IL18 IL1B IL6 MAVS TNF
49 immune system process GO:0002376 10.05 DDX58 MAVS OAS3 RSAD2 TLR8
50 innate immune response GO:0045087 10.05 BST2 DDX58 MAVS OAS3 RSAD2 TLR8

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 BST2 CCL5 CD40LG DDX58 IL18 IL1B
2 double-stranded RNA binding GO:0003725 9.13 DDX58 OAS3 TLR8
3 cytokine activity GO:0005125 9.1 CCL5 CD40LG IL18 IL1B IL6 TNF

Sources for Chikungunya

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