MCID: CHK001
MIFTS: 47

Chikungunya malady

Rare diseases, Infectious diseases, Bone diseases categories

Aliases & Classifications for Chikungunya

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 28ICD10 via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Chikungunya:

Name: Chikungunya 10 45 12 51
Chikungunya Fever 10 45 2
Chikungunya Virus Infection 45 65
Arbovirus a Chikungunya Type 45
 
Chikv Infection 45
Chik 45
Ck 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
chikungunya:
Prevalence: <1/1000000 (France); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:0050012
Orphanet51 324625
ICD10 via Orphanet28 A92.0
ICD1027 A92.0

Summaries for Chikungunya

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Disease Ontology:10 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

MalaCards based summary: Chikungunya, also known as chikungunya fever, is related to acquired immunodeficiency syndrome and dengue shock syndrome, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3, 100kDa), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include joint, bone and monocytes, and related mouse phenotypes are hematopoietic system and mortality/aging.

CDC:2 Click here to view a Digital Press Kit on chikungunya from the CDC News Room.

Wikipedia:68 Chikungunya (/ˌtʃɪkənˈɡʌnjə/CHI-kən-GUUN-yə; Makonde for \"that which bends up\") is an... more...

Related Diseases for Chikungunya

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Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.3CCL5, IL1B, IL6
2dengue shock syndrome30.0CD40LG, DDX58
3rheumatoid arthritis29.9CCL5, CD40LG, IL18, IL1B, IL6
4asthma29.5CCL5, CD40LG, IL18, IL1B, IL6
5malaria29.5CCL5, CD40LG, HSP90AA1, IL18, IL1B, IL6
6myocardial infarction10.6
7acute myocardial infarction10.6
8arthritis10.6
9ck syndrome10.6
10viral infectious disease10.4
11encephalitis10.3
12diabetic ketoacidosis10.3IL1B, IL6
13plantar nerve lesion10.3IL1B, IL6
14larynx sarcoma10.3IL1B, IL6
15wissler's syndrome10.3IL1B, IL6
16chorioamnionitis10.3IL1B, IL6
17glossopharyngeal nerve disease10.3IL1B, IL6
18hyperthyroxinemia10.3IL1B, IL6
19intermediate cell type choroid melanoma10.3IL1B, IL6
20hepatic angiomyolipoma10.3IL1B, IL6
21vaginal glandular tumor10.3IL1B, IL6
22familiar fallopian tube carcinoma10.3IL1B, IL6
23vascular cancer10.3IL1B, IL6
24lacrimal gland adenocarcinoma10.3IL1B, IL6
25breast cancer10.3
26ischemia10.3
27plantar fasciitis10.3IL18, IL6
28withdrawal disorder10.2BST2, OAS3
29familial mediterranean fever, ar10.2
30yellow fever10.2
31chronic pain10.2
32breast epithelioid hemangioma10.2IL18, IL6
33gingival overgrowth10.2IL1B, IL6
34early-onset, autosomal dominant alzheimer disease10.2IL1B, IL6
35kartagener syndrome10.2IL1B, IL6
36cinca syndrome10.2IL18, IL1B
37acute disseminated encephalomyelitis10.2IL18, IL6
38endophthalmitis10.2IL1B, IL6
39protozoal dysentery10.2CD40LG, IL6
40cerebellar astrocytoma10.2CD40LG, IL6
41loeffler syndrome10.2CCL5, IL6
42intestinal impaction10.2CD40LG, IL6
43collagenous colitis10.2CD40LG, IL1B
44lung cancer10.2
45adenoma10.2
46muscular dystrophy10.2
47acute female pelvic peritonitis10.2IL1B, IL6
48intracranial embolism10.2CD40LG, IL18
49anterior cerebral artery infarction10.2CD40LG, IL6
50arthropathy10.2

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Symptoms for Chikungunya

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Symptoms:

 10
  • fever
  • arthralgia
  • maculopapular rash

Drugs & Therapeutics for Chikungunya

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Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
chloroquineapprovedPhase 313754-05-72719
Synonyms:
( -)-Chloroquine
(+)-Chloroquine
(-)-Chloroquine
(R)-(-)-Chloroquine
3377 RP opalate
3545-67-3
50-63-5
54-05-7
56598-66-4
58175-86-3
58175-87-4
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline
7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
AB00053436
AC1L1EB8
AC1Q2ZA7
AC1Q2ZA8
Amokin
Aralen
Aralen HCl
Arechin
Arechine
Arequin
Arolen
Arthrochin
Artrichin
Avlochlor
Avloclor
BPBio1_000655
BRD-A91699651-065-01-1
BRN 0482809
BSPBio_000595
BSPBio_002001
Bemaco
Bemaphate
Bemasulph
Benaquin
Bipiquin
C07625
C18H26ClN3
CCRIS 3439
CHEBI:3638
CHEMBL76
CID2719
CQ
CU-01000012392-2
Capquin
Chemochin
Chingamin
Chloraquine
Chlorochin
Chlorochine
Chlorochinum
Chloroin
Chloroquin
Chloroquina
Chloroquine
Chloroquine (USP/INN)
Chloroquine (VAN)
Chloroquine Bis-Phosphoric Acid
Chloroquine Phosphate
Chloroquine [USAN:INN:BAN]
Chloroquine phosphate
Chloroquinium
Chloroquinum
Chloroquinum [INN-Latin]
Chlorquin
Cidanchin
Clorochina
Clorochina [DCIT]
Cloroquina
Cloroquina [INN-Spanish]
Cocartrit
D02366
DB00608
Dawaquin
Delagil
Dichinalex
DivK1c_000404
EINECS 200-191-2
Elestol
Gontochin
Gontochin phosphate
HMS2090O03
HSDB 3029
Heliopar
Hydroxychloroquine Sulfate
IDI1_000404
Imagon
Ipsen 225
 
Iroquine
KBio1_000404
KBio2_000592
KBio2_003160
KBio2_005728
KBio3_001221
KBioGR_000778
KBioSS_000592
Khingamin
Klorokin
LS-141726
Lapaquin
Lopac0_000296
Malaquin
Malaquin (*Diphosphate*)
Malaren
Malarex
Mesylith
Miniquine
MolMap_000009
MolPort-001-783-623
N(4)-(7-chloro-4-Quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
NCGC00015256-04
NCGC00162120-01
NCI60_000894
NINDS_000404
NSC 187208
NSC14050
NSC187208
Neochin
Nivachine
Nivaquine
Nivaquine B
Nivaquine b
Pfizerquine
Plaquenil
Prestwick0_000548
Prestwick1_000548
Prestwick2_000548
Prestwick3_000548
Quinachlor
Quinagamin
Quinagamine
Quinercyl
Quingamine
Quinilon
Quinoscan
RP 3377
RP-3377
Resochen
Resochin
Resoquina
Resoquine
Reumachlor
Reumaquin
Rivoquine
Ro 01-6014/N2
Ronaquine
Roquine
SMP2_000034
SN 6718
SN-7618
SPBio_000174
SPBio_002516
ST 21
ST 21 (pharmaceutical)
Sanoquin
Silbesan
Siragan
Solprina
Sopaquin
Spectrum2_000127
Spectrum3_000341
Spectrum4_000279
Spectrum5_000707
Spectrum_000132
Tanakan
Tanakene
Tresochin
Trochin
UNII-886U3H6UFF
W 7618
WIN 244
WLN: T66 BNJ EMY1&3N2&2 IG
chloroquine
nchembio.215-comp4
nchembio.368-comp8
nchembio.87-comp17
{4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
2AnthelminticsPhase 3363
3Chloroquine diphosphatePhase 313750-63-5
4Rho(D) Immune GlobulinPhase 1, Phase 2198
5Immunoglobulins, IntravenousPhase 1, Phase 2203

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya DiseaseTerminatedNCT00391313Phase 3
2Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy AdultsRecruitingNCT02562482Phase 2
3Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous ImmunoglobulinsRecruitingNCT02230163Phase 1, Phase 2
4Chikungunya Virus Vaccine Trial in Healthy AdultsCompletedNCT01489358Phase 1
5The Pilot Study of Chikungunya Virus Infections in Southern TaiwanRecruitingNCT02174341
6Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV InfectionRecruitingNCT02553369
7A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet ComponentsRecruitingNCT02305732
8Pilot Survey of Dengue Fever in Solomon IslandsRecruitingNCT01868399
9Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of CongoRecruitingNCT02656862
10Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With ChikungunyaActive, not recruitingNCT02281123
11Chikungunya Arthritis in the AmericasNot yet recruitingNCT02463968

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

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Anatomical Context for Chikungunya

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MalaCards organs/tissues related to Chikungunya:

33
Bone, Monocytes, Testes, T cells, Salivary gland, Eye, Brain

FMA organs/tissues related to Chikungunya:

16
Joint

Animal Models for Chikungunya or affiliated genes

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MGI Mouse Phenotypes related to Chikungunya:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.1BST2, CCL5, CD40LG, DDX58, IL18, IL1B
2MP:00107686.4CD40LG, DDX58, HSP90AA1, IL18, IL1B, IL6
3MP:00053876.3BST2, CCL5, CD40LG, DDX58, HSP90AA1, IL18

Publications for Chikungunya

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Articles related to Chikungunya:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Development of a Real-Time Cell Analysing (RTCA) method as a fast and accurate screen for the selection of chikungunya virus replication inhibitors. (26553263)
2015
2
Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012. (24499011)
2014
3
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication. (25282648)
2014
4
Chikungunya virus nsP2-mediated host shut-off disables the unfolded protein response. (25395592)
2014
5
Genomes to hits in silico - a country path today, a highway tomorrow: a case study of chikungunya. (23260020)
2013
6
Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces. (24009512)
2013
7
Development of a high-throughput antiviral assay for screening inhibitors of chikungunya virus and generation of drug-resistant mutations in cultured cells. (23821286)
2013
8
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. (23275491)
2013
9
Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. (24129946)
2013
10
Outbreak of chikungunya virus infection, Vanimo, Papua New Guinea. (23965757)
2013
11
Travel-Associated Chikungunya Cases in South Korea during 2009-2010. (24159550)
2013
12
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. (23936572)
2013
13
Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation. (24126361)
2013
14
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. (23864632)
2013
15
Travelers as sentinels for chikungunya fever, Brazil. (22377013)
2012
16
High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand. (22188545)
2012
17
Chikungunya myeloradiculopathy: a rare complication. (23326078)
2012
18
Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae). (21750871)
2012
19
Chikungunya virus infection of corneal grafts. (22706183)
2012
20
Differential diagnosis of Chikungunya, dengue viral infection and other acute febrile illnesses in children. (22301475)
2012
21
Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. (22837213)
2012
22
Coinfection with dengue and chikungunya--a case report. (23738415)
2012
23
Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus. (22546647)
2012
24
Chikungunya virus infection, a threat to public health. (22561790)
2012
25
Prevalence of chikungunya in urban field practice area of a private medical college, chennai. (21976797)
2011
26
Isolation and molecular characterization of Chikungunya virus from the Andaman and Nicobar archipelago, India: evidence of an East, Central, and South African genotype. (22136155)
2011
27
Chikungunya virus: host pathogen interaction. (21412934)
2011
28
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. (21811589)
2011
29
Chikungunya epidemic-related mortality. (21073766)
2011
30
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. (22014740)
2011
31
Clinical Profile of Chikungunya Patients during the Epidemic of 2007 in Kerala, India. (21887052)
2011
32
Competitive suppression between chikungunya and dengue virus in Aedes albopictus c6/36 cell line. (22299407)
2011
33
Exposure to chikungunya virus and adult longevity in Aedes aegypti (L.) and Aedes albopictus (Skuse). (20618649)
2010
34
Different lineages of Chikungunya virus in Equatorial Guinea in 2002 and 2006. (20207882)
2010
35
Urological manifestations of Chikungunya fever: A single centre experience. (20981198)
2010
36
Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus. (19725768)
2010
37
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. (20952847)
2010
38
CHIKVPRO - a protein sequence annotation database for chikungunya virus. (21346870)
2010
39
First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality! (21040155)
2010
40
Reemergence of Chikungunya virus in Indian Subcontinent. (23637474)
2010
41
Tracing the path of Chikungunya virus--evolution and adaptation. (20654736)
2010
42
Chikungunya virus infection during pregnancy, Reunion, France, 2006. (20202416)
2010
43
Suppressing Aedes albopictus, an emerging vector of dengue and chikungunya viruses, by a novel combination of a monomolecular film and an insect-growth regulator. (20439963)
2010
44
Breeding potential of Aedes albopictus (Skuse, 1895) in chikungunya affected areas of Kerala, India. (21245624)
2010
45
Whole-genome characterisation of Chikungunya virus from Aedes albopictus collected in Thailand. (20507700)
2010
46
Chikungunya: an emerging and spreading arthropod-borne viral disease. (20009275)
2009
47
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak. (19857273)
2009
48
A suspicion of chikungunya leading to a diagnosis of angioimmunoblastic T-cell lymphoma. (19173091)
2009
49
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. (20003320)
2009
50
Immuno-biology of Chikungunya and implications for disease intervention. (19737625)
2009

Variations for Chikungunya

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Expression for genes affiliated with Chikungunya

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Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL1B, IL6
29.8IL1B, IL6
39.7CCL5, IL6
49.5CCL5, HSP90AA1
59.5IL18, IL1B
69.5IL18, IL1B
79.4CCL5, IL1B, IL6
89.4CCL5, IL1B, IL6
99.2IL18, IL1B, IL6
10
Salmonella infection (KEGG)
Show member pathways
9.2IL18, IL1B, IL6
11
Show member pathways
9.2IL18, IL1B, IL6
129.2IL18, IL1B, IL6
139.2IL18, IL1B, IL6
148.8CD40LG, DDX58, IL1B
158.7CCL5, IL18, IL1B, IL6
16
Show member pathways
8.5BST2, IL18, IL1B, IL6, OAS3
178.4CCL5, CD40LG, DDX58, IL1B
188.3CD40LG, IL18, IL1B, IL6
19
Show member pathways
8.3CCL5, DDX58, IL18, IL1B, IL6
20
Show member pathways
8.2CCL5, HSP90AA1, IL18, IL1B, IL6
21
Show member pathways
8.0CCL5, DDX58, IL18, IL1B, IL6, OAS3
22
Show member pathways
7.8CD40LG, HSP90AA1, IL18, IL1B, IL6
23
Show member pathways
7.4CCL5, CD40LG, HSP90AA1, IL18, IL1B, IL6
24
Show member pathways
6.4BST2, CD40LG, DDX58, HSP90AA1, IL18, IL1B

GO Terms for genes affiliated with Chikungunya

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Cellular components related to Chikungunya according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.1CCL5, CD40LG, IL18, IL1B, IL6, OAS3

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-6GO:007135410.5IL6, PHB
2positive regulation of fever generationGO:003162210.3CCL5, IL1B
3cellular response to lipidGO:007139610.3CCL5, IL1B
4glycoprotein metabolic processGO:000910010.3IL1B, PCSK6
5positive regulation of JAK-STAT cascadeGO:004642710.2CCL5, IL6
6positive regulation of interleukin-8 productionGO:003275710.2DDX58, IL1B
7positive regulation of NF-kappaB import into nucleusGO:004234610.1IL18, IL1B
8negative regulation of viral genome replicationGO:004507110.0BST2, CCL5, OAS3
9response to antibioticGO:004667710.0HSP90AA1, IL6
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.0IL18, IL6
11positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9DDX58, IL1B, IL6
12response to glucocorticoidGO:00513849.9CCL5, IL1B, IL6
13response to organic cyclic compoundGO:00140709.8CCL5, IL1B, IL6
14defense response to virusGO:00516079.8BST2, IL6, OAS3
15response to lipopolysaccharideGO:00324969.8CCL5, IL1B, IL6
16leukocyte cell-cell adhesionGO:00071599.8CCL5, CD40LG
17positive regulation of interleukin-6 productionGO:00327559.7DDX58, IL1B, IL6
18positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.7DDX58, IL18, IL1B
19lipopolysaccharide-mediated signaling pathwayGO:00316639.7CCL5, IL18, IL1B
20positive regulation of T cell proliferationGO:00421029.6CCL5, IL1B, IL6
21positive regulation of nitric oxide biosynthetic processGO:00454299.6HSP90AA1, IL1B, IL6
22response to heatGO:00094089.6HSP90AA1, IL1B, IL6
23cellular response to organic cyclic compoundGO:00714079.5CCL5, IL18, IL1B
24response to cytokineGO:00340979.4CCL5, IL6, PHB
25positive regulation of ERK1 and ERK2 cascadeGO:00703749.3CCL5, IL1B, IL6, PHB
26cytokine-mediated signaling pathwayGO:00192219.2BST2, IL1B, IL6, OAS3
27cell-cell signalingGO:00072679.2BST2, CCL5, IL18, IL1B
28cellular response to lipopolysaccharideGO:00712229.2CCL5, IL18, IL1B, IL6
29response to virusGO:00096159.1BST2, CCL5, DDX58, OAS3
30agingGO:00075689.1CCL5, IL1B, IL6
31response to drugGO:00424939.0CCL5, IL1B, IL6, PHB
32inflammatory responseGO:00069548.3CCL5, CD40LG, IL18, IL1B, IL6
33positive regulation of gene expressionGO:00106288.3CCL5, DDX58, IL18, IL1B, IL6
34immune responseGO:00069558.0CCL5, CD40LG, IL18, IL1B, IL6, OAS3

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3CD40LG, IL18, IL1B, IL6

Sources for Chikungunya

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet