MCID: CHK001
MIFTS: 49

Chikungunya malady

Categories: Rare diseases, Infectious diseases, Bone diseases

Aliases & Classifications for Chikungunya

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Aliases & Descriptions for Chikungunya:

Name: Chikungunya 11 46 13 52 36
Chikungunya Fever 11 46 2 66
Ck 46 2
Arbovirus a Chikungunya Type 46
 
Chikungunya Virus Infection 46
Chikv Infection 46
Chik 46

Characteristics:

Orphanet epidemiological data:

52
chikungunya:
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:0050012
Orphanet52 ORPHA324625
ICD10 via Orphanet29 A92.0
ICD1028 A92.0

Summaries for Chikungunya

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MedlinePlus:36 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and zika virus. rarely, it can spread from mother to newborn around the time of birth. it may also possibly spread through infected blood. there have been outbreaks of chikungunya virus in africa, asia, europe, the indian and pacific oceans, the caribbean, and central and south america. most people who are infected will have symptoms, which can be severe. they usually start 3-7 days after being bitten by an infected mosquito. the most common symptoms are fever and joint pain. other symptoms may include headache, muscle pain, joint swelling, and rash. most people feel better within a week. in some cases, however, the joint pain may last for months. people at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. a blood test can show whether you have chikungunya virus. there are no vaccines or medicines to treat it. drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. the best way to prevent chikungunya infection is to avoid mosquito bites: use insect repellent wear clothes that cover your arms, legs, and feet stay in places that have air conditioning or that use window and door screens centers for disease control and prevention

MalaCards based summary: Chikungunya, also known as chikungunya fever, is related to oral candidiasis and systemic lupus erythematosus, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include joint, testes and heart, and related mouse phenotype hematopoietic system.

Disease Ontology:11 A viral infectious disease that results in infection located in joint, has material basis in chikungunya virus, which is transmitted by aedes mosquito bite. the infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC:2 Click here to view a Digital Press Kit on chikungunya from the CDC News Room.

Wikipedia:69 Chikungunya is an infection caused by the chikungunya virus. Symptoms include the sudden onset of fever... more...

Related Diseases for Chikungunya

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Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1oral candidiasis29.2IL18, IL1B, IL6, MIF
2systemic lupus erythematosus28.5CCL5, CD40LG, IL18, IL6
3asthma28.1CCL5, CD40LG, IL18, IL1B, IL6
4malaria28.1CCL5, CD40LG, IL18, IL1B, IL6, MIF
5rheumatoid arthritis27.9CCL5, CD40LG, IL18, IL1B, IL6, MIF
6ck syndrome12.4
7isolated hyperckemia10.9
8corneal deposit10.7IL1B, IL6
9tarsal tunnel syndrome10.7IL1B, IL6
10scrotum paget's disease10.7IL1B, IL6
11hemoglobinopathy10.7IL1B, IL6
12melorheostosis10.7IL1B, IL6
13infancy electroclinical syndrome10.7IL1B, IL6
14hypothyroidism10.7IL1B, IL6
15autoimmune polyendocrine syndrome10.7IL1B, IL6
16kaposi sarcoma10.7IL6, MIF
17skin disease10.7IL1B, IL6
18scarlet fever10.7IL1B, IL6
19subglottis neoplasm10.6IL1B, IL6
20lung occult adenocarcinoma10.6IL1B, IL6
21neuroaxonal dystrophy10.6BST2, OAS3
22inflammatory spondylopathy10.6IL1B, IL6
23ocular cancer10.6IL1B, IL6
24ethmoid sinus cancer10.6IL6, MIF
25periodic paralyses10.6IL1B, IL6
26paraneoplastic polyneuropathy10.6IL1B, IL6
27scn8a encephalopathy10.6IL1B, IL6
28philophthalmiasis10.6IL1B, IL6
29thoracic aortic aneurysm10.5IL1B, IL6
30ulcerative colitis10.5IL1B, IL6
31ampulla of vater neoplasm10.5IL1B, IL6
32monoclonal paraproteinemia10.5CD40LG, IL6
33disease_ontology10.5CD40LG, IL6
34benign mammary dysplasia10.5CCL5, IL6
35renal artery disease10.5IL1B, IL6
36cyclothymic disorder10.5CD40LG, IL6
37ileocolitis10.4CD40LG, IL1B
38sweat gland cancer10.4CD40LG, IL6
39myocardial infarction10.4
40african histoplasmosis10.4CD40LG, IL1B
41silo filler's disease10.4IL18, IL1B
42acute myocardial infarction10.4
43echinococcosis10.4IL1B, IL6
44pulmonary alveolar proteinosis10.3CD40LG, MIF
45arteriolosclerosis10.3IL18, IL6
46epididymis adenomatoid tumor10.3CD40LG, IL6
47neurofibroma of the esophagus10.3IL18, IL6
48renal cell carcinoma 410.3IL18, IL6
49leukostasis10.3CD40LG, IL6
50familial dupuytren contracture10.3IL18, IL1B

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to chikungunya

Symptoms for Chikungunya

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Symptoms:

 11
  • f
  • a
  • m

Drugs & Therapeutics for Chikungunya

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Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Chloroquine diphosphatePhase 314550-63-5
2
chloroquinePhase 314554-05-72719
Synonyms:
( -)-Chloroquine
(+)-Chloroquine
(-)-Chloroquine
(R)-(-)-Chloroquine
3377 RP opalate
3545-67-3
50-63-5
54-05-7
56598-66-4
58175-86-3
58175-87-4
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline
7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
AB00053436
AC1L1EB8
AC1Q2ZA7
AC1Q2ZA8
Amokin
Aralen
Aralen HCl
Arechin
Arechine
Arequin
Arolen
Arthrochin
Artrichin
Avlochlor
Avloclor
BPBio1_000655
BRD-A91699651-065-01-1
BRN 0482809
BSPBio_000595
BSPBio_002001
Bemaco
Bemaphate
Bemasulph
Benaquin
Bipiquin
C07625
C18H26ClN3
CCRIS 3439
CHEBI:3638
CHEMBL76
CID2719
CQ
CU-01000012392-2
Capquin
Chemochin
Chingamin
Chloraquine
Chlorochin
Chlorochine
Chlorochinum
Chloroin
Chloroquin
Chloroquina
Chloroquine
Chloroquine (USP/INN)
Chloroquine (VAN)
Chloroquine Bis-Phosphoric Acid
Chloroquine Phosphate
Chloroquine [USAN:INN:BAN]
Chloroquine phosphate
Chloroquinium
Chloroquinum
Chloroquinum [INN-Latin]
Chlorquin
Cidanchin
Clorochina
Clorochina [DCIT]
Cloroquina
Cloroquina [INN-Spanish]
Cocartrit
D02366
DB00608
Dawaquin
Delagil
Dichinalex
DivK1c_000404
EINECS 200-191-2
Elestol
Gontochin
Gontochin phosphate
HMS2090O03
HSDB 3029
Heliopar
Hydroxychloroquine Sulfate
IDI1_000404
Imagon
 
Ipsen 225
Iroquine
KBio1_000404
KBio2_000592
KBio2_003160
KBio2_005728
KBio3_001221
KBioGR_000778
KBioSS_000592
Khingamin
Klorokin
LS-141726
Lapaquin
Lopac0_000296
Malaquin
Malaquin (*Diphosphate*)
Malaren
Malarex
Mesylith
Miniquine
MolMap_000009
MolPort-001-783-623
N(4)-(7-chloro-4-Quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
NCGC00015256-04
NCGC00162120-01
NCI60_000894
NINDS_000404
NSC 187208
NSC14050
NSC187208
Neochin
Nivachine
Nivaquine
Nivaquine B
Pfizerquine
Plaquenil
Prestwick0_000548
Prestwick1_000548
Prestwick2_000548
Prestwick3_000548
Quinachlor
Quinagamin
Quinagamine
Quinercyl
Quingamine
Quinilon
Quinoscan
RP 3377
RP-3377
Resochen
Resochin
Resoquina
Resoquine
Reumachlor
Reumaquin
Rivoquine
Ro 01-6014/N2
Ronaquine
Roquine
SMP2_000034
SN 6718
SN-7618
SPBio_000174
SPBio_002516
ST 21
ST 21 (pharmaceutical)
Sanoquin
Silbesan
Siragan
Solprina
Sopaquin
Spectrum2_000127
Spectrum3_000341
Spectrum4_000279
Spectrum5_000707
Spectrum_000132
Tanakan
Tanakene
Tresochin
Trochin
UNII-886U3H6UFF
W 7618
WIN 244
WLN: T66 BNJ EMY1&3N2&2 IG
chloroquine
nchembio.215-comp4
nchembio.368-comp8
nchembio.87-comp17
{4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya DiseaseTerminatedNCT00391313Phase 3
2Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy AdultsRecruitingNCT02562482Phase 2
3Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous ImmunoglobulinsRecruitingNCT02230163Phase 1, Phase 2
4Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya VaccineNot yet recruitingNCT02861586Phase 2
5Chikungunya Virus Vaccine Trial in Healthy AdultsCompletedNCT01489358Phase 1
6Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV InfectionCompletedNCT02553369
7RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus InfectionRecruitingNCT02714985
8The Pilot Study of Chikungunya Virus Infections in Southern TaiwanRecruitingNCT02174341
9Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 YearsRecruitingNCT02901509
10The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in MexicoRecruitingNCT02831699
11A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet ComponentsRecruitingNCT02305732
12Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)RecruitingNCT02794181
13Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
14Zika and Microcephaly: Case-control StudyRecruitingNCT02741882
15Pilot Survey of Dengue Fever in Solomon IslandsRecruitingNCT01868399
16Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of CongoRecruitingNCT02656862
17An Open Label Study of IgG Fc Glycan Composition in Human ImmunityRecruitingNCT01967238
18Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With ChikungunyaActive, not recruitingNCT02281123
19Chikungunya Arthritis in the AmericasNot yet recruitingNCT02463968

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

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Anatomical Context for Chikungunya

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MalaCards organs/tissues related to Chikungunya:

34
Testes, Heart, Monocytes, T cells, Bone, Eye, Salivary gland

FMA organs/tissues related to Chikungunya:

17
Joint

Animal Models for Chikungunya or affiliated genes

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MGI Mouse Phenotypes related to Chikungunya:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.9CCL5, CD40LG, DDX58, IL18, IL1B, IL6

Publications for Chikungunya

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Articles related to Chikungunya:

(show top 50)    (show all 633)
idTitleAuthorsYear
1
Febrile or Exanthematous Illness Associated with Zika, Dengue, and Chikungunya Viruses, Panama. (27139219)
2016
2
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. (27105216)
2016
3
Resolution of a Chikungunya Outbreak in a Prospective Cohort, Cebu, Philippines, 2012-2014. (27649081)
2016
4
A virus-like particle vaccine elicits broad neutralizing antibody responses in humans to all Chikungunya virus genotypes. (27655868)
2016
5
Molecular Characterisation of Clinical Isolates of Chikungunya Virus: A Study from Tertiary Care Hospitals in Southern India. (27134872)
2016
6
Development of a Real-Time Cell Analysing (RTCA) method as a fast and accurate screen for the selection of chikungunya virus replication inhibitors. (26553263)
2015
7
Chikungunya virus pathogenesis and immunity. (25897810)
2015
8
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication. (25282648)
2014
9
Chikungunya virus nsP2-mediated host shut-off disables the unfolded protein response. (25395592)
2014
10
An agent-based model driven by tropical rainfall to understand the spatio-temporal heterogeneity of a chikungunya outbreak. (23958228)
2014
11
Next Generation Sequencing Reveals Regulation of Distinct Aedes microRNAs during Chikungunya Virus Development. (24421911)
2014
12
Chikungunya: acute Fever, rash and debilitating arthralgias in a returning traveler from haiti. (25345984)
2014
13
Genomes to hits in silico - a country path today, a highway tomorrow: a case study of chikungunya. (23260020)
2013
14
Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces. (24009512)
2013
15
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. (23275491)
2013
16
Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. (24129946)
2013
17
Outbreak of chikungunya virus infection, Vanimo, Papua New Guinea. (23965757)
2013
18
Travel-Associated Chikungunya Cases in South Korea during 2009-2010. (24159550)
2013
19
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. (23936572)
2013
20
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. (23864632)
2013
21
Nonstructural protein 2 (nsP2) of Chikungunya virus (CHIKV) enhances protective immunity mediated by a CHIKV envelope protein expressing DNA Vaccine. (23409931)
2013
22
Chikungunya-related arthritis: case report and review of the literature. (23608542)
2013
23
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. (24069479)
2013
24
Production of recombinant Chikungunya virus envelope 2 protein in Escherichia coli. (24337252)
2013
25
Administration of E2 and NS1 siRNAs inhibit chikungunya virus replication in vitro and protects mice infected with the virus. (24040429)
2013
26
The 2005-2007 Chikungunya epidemic in RAcunion: ambiguous etiologies, memories, and meaning-making. (23406067)
2013
27
Travelers as sentinels for chikungunya fever, Brazil. (22377013)
2012
28
Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae). (21750871)
2012
29
Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus. (22546647)
2012
30
Chikungunya outbreak in Guangdong Province, China, 2010. (22377135)
2012
31
Post chikungunya brain stem encephalitis. (23029750)
2012
32
Prevalence of chikungunya in urban field practice area of a private medical college, chennai. (21976797)
2011
33
Isolation and molecular characterization of Chikungunya virus from the Andaman and Nicobar archipelago, India: evidence of an East, Central, and South African genotype. (22136155)
2011
34
Chikungunya virus: host pathogen interaction. (21412934)
2011
35
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. (21811589)
2011
36
Chikungunya epidemic-related mortality. (21073766)
2011
37
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. (22014740)
2011
38
Clinical Profile of Chikungunya Patients during the Epidemic of 2007 in Kerala, India. (21887052)
2011
39
Competitive suppression between chikungunya and dengue virus in Aedes albopictus c6/36 cell line. (22299407)
2011
40
The chikungunya disease: modeling, vector and transmission global dynamics. (21070789)
2011
41
Different lineages of Chikungunya virus in Equatorial Guinea in 2002 and 2006. (20207882)
2010
42
Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus. (19725768)
2010
43
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. (20952847)
2010
44
CHIKVPRO - a protein sequence annotation database for chikungunya virus. (21346870)
2010
45
Reemergence of Chikungunya virus in Indian Subcontinent. (23637474)
2010
46
Tracing the path of Chikungunya virus--evolution and adaptation. (20654736)
2010
47
Whole-genome characterisation of Chikungunya virus from Aedes albopictus collected in Thailand. (20507700)
2010
48
Immuno-biology of Chikungunya and implications for disease intervention. (19737625)
2009
49
Sporadic cases of chikungunya, RAcunion Island, August 2009. (19728980)
2009
50
Assessing the risk of importing dengue and chikungunya viruses to the European Union. (21352765)
2009

Variations for Chikungunya

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Expression for genes affiliated with Chikungunya

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Search GEO for disease gene expression data for Chikungunya.

Pathways for genes affiliated with Chikungunya

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Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL1B, IL6
29.7IL1B, IL6
39.5IL6, MIF
49.3CCL5, IL1B, IL6
59.3CCL5, IL1B, IL6
69.2IL18, IL1B
79.2IL18, IL1B
89.2CD209, IL1B, IL6
99.2CD40LG, DDX58, IL1B
109.1IL1B, IL6, MIF
11
Show member pathways
9.1IL1B, IL6, MIF
12
Show member pathways
8.9IL18, IL1B, IL6
13
Show member pathways
8.9IL18, IL1B, IL6
148.9IL18, IL1B, IL6
158.9IL18, IL1B, IL6
16
Show member pathways
8.9CCL5, DDX58, IL1B, IL6
178.7CCL5, CD40LG, DDX58, IL1B
188.5CCL5, IL18, IL1B, IL6
19
Show member pathways
8.5CCL5, IL18, IL1B, IL6
20
Show member pathways
8.5CCL5, IL18, IL1B, IL6
218.4CD40LG, IL18, IL1B, IL6
22
Show member pathways
8.4CD40LG, IL18, IL1B, IL6
23
Show member pathways
8.4CD209, IL18, IL1B, IL6
248.4CD209, IL18, IL1B, IL6
25
Show member pathways
8.3BST2, IL18, IL1B, IL6, OAS3
26
Show member pathways
8.1CCL5, DDX58, IL18, IL1B, IL6
277.9CCL5, CD40LG, IL18, IL1B, IL6
28
Show member pathways
7.3CCL5, CD209, DDX58, IL18, IL1B, IL6
29
Show member pathways
6.6BST2, CD209, CD40LG, DDX58, IL18, IL1B

GO Terms for genes affiliated with Chikungunya

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Cellular components related to Chikungunya according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099867.9BST2, CD209, CD40LG, MIF, PHB
2extracellular spaceGO:00056157.0CCL5, CD40LG, IL18, IL1B, IL6, MIF

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generationGO:003162210.2CCL5, IL1B
2positive regulation of JAK-STAT cascadeGO:004642710.1CCL5, IL6
3positive regulation of interleukin-8 productionGO:003275710.0DDX58, IL1B
4negative regulation of viral genome replicationGO:004507110.0BST2, CCL5, OAS3
5positive regulation of NF-kappaB import into nucleusGO:00423469.9IL18, IL1B
6positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7DDX58, IL1B, IL6
7positive regulation of interleukin-6 productionGO:00327559.7DDX58, IL1B, IL6
8defense response to virusGO:00516079.6BST2, IL6, OAS3
9positive regulation of NF-kappaB transcription factor activityGO:00510929.6CD40LG, IL1B, IL6
10leukocyte cell-cell adhesionGO:00071599.6CCL5, CD209, CD40LG
11lipopolysaccharide-mediated signaling pathwayGO:00316639.4CCL5, IL18, IL1B
12response to virusGO:00096159.2BST2, CCL5, DDX58, OAS3
13cellular response to organic cyclic compoundGO:00714079.2CCL5, IL18, IL1B
14positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.2DDX58, IL18, IL1B
15positive regulation of phosphorylationGO:00423279.1CCL5, MIF
16innate immune responseGO:00450878.9BST2, CD209, DDX58, MIF
17positive regulation of T cell proliferationGO:00421028.9CCL5, CD40LG, IL1B, IL6
18cell-cell signalingGO:00072678.7BST2, CCL5, IL18, IL1B
19positive regulation of gene expressionGO:00106288.4DDX58, IL18, IL1B, IL6
20positive regulation of ERK1 and ERK2 cascadeGO:00703748.4CCL5, IL1B, IL6, MIF, PHB
21inflammatory responseGO:00069547.6CCL5, CD40LG, IL18, IL1B, IL6, MIF

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.3CCL5, MIF
2cytokine activityGO:00051257.8CD40LG, IL18, IL1B, IL6, MIF

Sources for Chikungunya

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet