Childhood Absence Epilepsy malady

Disease Ontology: A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.⁶

MalaCards: Childhood Absence Epilepsy, also known as petit mal seizure, is related to febrile seizures and febrile convulsions. An important gene associated with Childhood Absence Epilepsy is CACNA1H (calcium channel, voltage-dependent, T type, alpha 1H subunit), and among its related pathways are Neuronal System and Benzodiazepine Pathway, Pharmacodynamics. The drugs trimethadione and divalproex and the compounds Ethchlorvynol and Butalbital have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and nervous system.

Wikipedia: Childhood absence epilepsy (CAE), also known as pyknolepsy, is an idiopathic generalized epilepsy which...⁴⁴ more...

Aliases & Descriptions:

childhood absence epilepsy 6 32 petit mal seizure 6

absence epilepsy 43 pyknolepsy 6

Disease types for childhood absence epilepsy family:

epilepsy, childhood absence, susceptibility to, 2	epilepsy, childhood absence, susceptibility to, 4
epilepsy, childhood absence, susceptibility to, 5	epilepsy, childhood absence, susceptibility to, 6
epilepsy, childhood absence, 1

Diseases related to childhood absence epilepsy by text searches and GeneDecks gene sharing:

(show all 37)

id	Related Disease	Score	Top Affiliating Genes
1	febrile seizures	31.1	CHRNA4, GABRG2
2	febrile convulsions	29.5	CHRNA4, GABRG2
3	convulsions	28.9	GABRG2, GABBR1, CHRNA4, LGI4
4	juvenile myoclonic epilepsy	28.4	GABRA1, CLCN2
5	juvenile absence epilepsy	27.5	GABRB3, GABRA5, GABRA1, GABRG2, CACNA1H, CACNG3
6	absence epilepsy	26.9	GABRB3, GABRA5, CACNA1H, GABRA1, GABRG2, CACNA1I
7	seizures	26.5	DHFR, SLC2A1, ECA1, GABBR1, GABRG2, GABRA1
8	neuronitis	22.7	GABRG2, CACNA1G, SLC2A1, GABRA1, DHFR, CACNA1H
9	benign familial neonatal-infantile seizures	13.3	CHRNA4, GABRG2
10	autosomal dominant nocturnal frontal lobe epilepsy	13.3	CHRNA4, GABRG2
11	idiopathic generalized epilepsy	13.2	CACNA1H, CLCN2
12	merrf syndrome	13.2	CHRNA4, GABRG2
13	generalized epilepsy with febrile seizures plus	13.2	GABRG2, CHRNA4
14	epilepsies, partial	13.1	CHRNA4, GABRG2
15	angelman syndrome	12.9	GABRA5, GABRA1, GABRG2, GABRB3
16	autism spectrum disorder	12.8	GABRB3, CACNA1H, CHRNA4, GABRA5
17	mood disorder	12.7	GABBR1, GABRG2, GABRA1, GRIK1
18	focal epilepsy	12.6	CLCN2, GABRG2
19	autistic disorder	12.6	GABRB3, GRIK1, GABRA5
20	bipolar disorder	12.4	GABRG2, GABRB3, GRIK1, CHRNA4, GABRA1, GABRA5
21	temporal lobe epilepsy	12.3	GABRA5, GABRB3, GABBR1, GRIK1, LGI4
22	alcohol dependence	12.3	GRIK1, GABRB3, GABRA5, GABRA1, GABRG2, GABBR1
23	anorexia nervosa	12.0	GABBR1, GABRG2, GABRA1, GABRB3, KHDRBS3, GABRA5
24	pharyngitis	12.0	CACNA1H, CACNA1I, CACNA1G, KCNK9, CHRNA4
25	down syndrome	11.7	GABRG2, CHRNA4, GRIK1, DHFR, GABBR1
26	epilepsy syndrome	11.4	CHRNA4, SLC2A1, GABBR1, GABRG2, GABRB3, CLCN2
27	cerebritis	10.8	SLC2A1, GABRB3, CHRNA4, GRIK1, DHFR, GABBR1
28	schizophrenia	10.0	DHFR, CHRNA4, GABRB3, GABRA5, GABRA1, GABRG2
29	early onset absence epilepsy	7.8
30	epilepsy, childhood absence, 1	6.6
31	twinning	6.6
32	ataxia	5.7
33	cramps	5.7
34	episodic ataxia	5.7
35	migraine	5.7
36	migraine with aura	5.7
37	succinic semialdehyde dehydrogenase deficiency	5.7

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 clonazepam, divalproex, divalproex sodium, ethosuximide, mephobarbital, methsuximide, phensuximide, trimethadione, valproate sodium, valproic acid

MGI Mouse Phenotypes related to childhood absence epilepsy:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	8.4	GABRA5, GABRA1, SLC2A1, CACNA1G, CHRNA4, KCNK9
2	nervous system phenotype	MP:0003631	7.0	CLCN2, GABRG2, GABBR1, SLC2A1, CACNA1H, CACNG3
3	behavior/neurological phenotype	MP:0005386	6.6	GABBR1, GABRG2, GABRA1, GABRA5, GABRB3, SLC2A1

Articles related to childhood absence epilepsy:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. (18514161)	Tanaka M.... Delgado-Escueta A.V.	2008	GABRB3
2	Linkage and mutational analysis of CLCN2 in childhood absence epilepsy. (17580110)	Everett K.... Gardiner M.	2007	CLCN2
3	The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. (17215393)	Vitko I.... Perez-Reyes E.	2007	CACNA1H
4	Common polymorphisms in the CACNA1H gene associated with childhood absence epilepsy in Chinese Han population. (17156077)	Liang J.... Wu X.	2007	CACNA1H
5	Linkage and association analysis of CACNG3 in childhood absence epilepsy. (17264864)	Everett K.V.... Gardiner M.	2007	CACNG3
6	A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity. (16835263)	Urak L.... Fuchs K.	2006	GABRB3
7	Evaluation of CACNA1H in European patients with childhood absence epilepsy. (16504478)	Chioza B.... Gardiner R.M.	2006	CACNA1H
8	CACNA1I is not associated with childhood absence epilepsy in the Chinese Han population. (16939858)	Wang J.... Wu X.	2006	CACNA1I
9	New variants in the CACNA1H gene identified in childhood absence epilepsy. (16905256)	Liang J.... Wu X.	2006	CACNA1H
10	T-type calcium channel gene-CACNA1H is a susceptibility gene to childhood absence epilepsy (15833171)	Lu J.J.... Wu X.R.	2005	CACNA1H
11	Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. (15888660)	Vitko I.... Perez-Reyes E.	2005	CACNA1H
12	Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy. (14729682)	Khosravani H.... Zamponi G.W.	2004	CACNA1H
13	The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum. (15470132)	Kang J.Q.... Macdonald R.L.	2004	GABRG2
14	Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy. (14505228)	Gu W.... Steinlein O.K.	2004	LGI4
15	Case-control study and transmission/disequilibrium tests of the genes encoding GABRA5 and GABRB3 in a Chinese population affected by childhood absence epilepsy. (15498372)	Lu J.J.... Wu X.R.	2004	GABRB3, GABRA5
16	T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population. (12676336)	Chen Y.... Wu X.	2003	CACNA1G
17	Association between genetic variation of CACNA1H and childhood absence epilepsy. (12891677)	Chen Y.... Wu X.	2003	CACNA1H
18	The gene encoding GABBR1 is not associated with childhood absence epilepsy in the Chinese Han population. (12770685)	Lu J.... Wu X.	2003	GABBR1
19	Linkage analysis between childhood absence epilepsy and genes encoding GABAA and GABAB receptors, voltage-dependent calcium channels, and the ECA1 region on chromosome 8q. (11904235)	Robinson R.... Gardiner R.M.	2002	GABBR1, ECA1
20	A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. (12117362)	Kananura C.... Steinlein O.K.	2002	GABRG2
21	Association analysis of childhood absence epilepsy by microsatellite DNA. (12194792)	Lu J.... Wu X.	2002	GABRB3
22	Mutation screen of the GABA(A) receptor gamma 2 subunit gene in Chinese patients with childhood absence epilepsy. (12384214)	Lu J.... Wu X.	2002	GABRG2
23	Case-control study and transmission/disequilibrium test of childhood absence epilepsy (12048673)	Lu J.... Wu X.	2002	GABRB3, GABRA5
24	T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients. (11463515)	Sugimoto Y.... Yamakawa K.	2001	CELF2, KHDRBS3
25	Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. (11326275)	Wallace R.H.... Berkovic S.F.	2001	GABRG2
26	Childhood absence epilepsy in 8q24: refinement of candidate region and construction of physical map. (10995568)	Sugimoto Y.... Yamakawa K.	2000	ECA1
27	Exclusion of the JRK/JH8 gene as a candidate for human childhood absence epilepsy mapped on 8q24. (10510981)	Morita R.... Yamakawa K.	1999	ECA1
28	Possible association between childhood absence epilepsy and the gene encoding GABRB3. (10509183)	Feucht M.... Aschauer H.	1999	GABRA5
29	JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24. (9675132)	Morita R.... Yamakawa K.	1998	JRK
30	Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24. (9758624)	Fong G.C.... Delgado-Escueta A.V.	1998	ECA1

Genes related to childhood absence epilepsy according to GeneCards:

(show all 20)

id	Symbol	Description	Score	GeneCards Section Context
1	CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	11.1	Publications, Summaries
2	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.1	Summaries
3	JRK	jerky homolog (mouse)	11.1	Functions, Publications, Summaries
4	CACNG3	calcium channel, voltage-dependent, gamma subunit 3	11.1	Summaries, Publications
5	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.0	Publications
6	GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	11.0	Publications
7	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	11.0	Publications
8	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	11.0
9	KCNK9	potassium channel, subfamily K, member 9	11.0
10	GRIK1	glutamate receptor, ionotropic, kainate 1	11.0
11	ECA1	epilepsy, childhood absence 1	11.0	Publications
12	LGI4	leucine-rich repeat LGI family, member 4	11.0	Publications
13	CLCN2	chloride channel, voltage-sensitive 2	11.0	Publications
14	CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	11.0	Publications
15	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
16	CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	11.0	Publications
17	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	11.0	Publications
18	CELF2	CUGBP, Elav-like family member 2	11.0	Publications
19	DHFR	dihydrofolate reductase	11.0
20	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0

Pathways related to childhood absence epilepsy according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Neuronal System38	9.8	GABRB3, GABRA5, GABRA1, GABRG2, CACNG3
2	Benzodiazepine Pathway, Pharmacodynamics34	9.8	GABRG2, GABRA1
3	Synaptic transmission- ion currents10	9.7	CACNA1H, CACNA1I, CACNA1G
4	nNOS Signaling in Skeletal Muscle36	9.7	CACNA1H, CACNG3, CACNA1I, CACNA1G
5	DREAM Repression and Dynorphin Expression36	9.7	CACNA1H, CACNG3, CACNA1I, CACNA1G
6	Fc-Gamma-RIIB Signaling in B-Cells36	9.7	CACNA1G, CACNA1I, CACNG3, CACNA1H
7	Fc-GammaR Pathway36	9.7	CACNA1G, CACNA1I, CACNG3, CACNA1H
8	CCR5 Pathway in Macrophages36	9.7	CACNA1G, CACNA1I, CACNG3, CACNA1H
9	BMP Pathway36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
10	Caspase Cascade36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
11	Transcription CREB pathway10	9.6	CACNA1G, CACNA1I, CACNG3, CACNA1H
12	Fc-EpsilonRI Pathway36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
13	PDGF Pathway36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
14	Androgen Signaling36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
15	Transcription_CREB pathway41	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
16	GABA signaling in brain10	9.6	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1
17	Calcium channels10	9.6	CACNA1H, CACNA1I, CACNA1G, CHRNA4
18	Calpain Protease Regulates Cellular Mechanics36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
19	Celecoxib Pathway, Pharmacodynamics34	9.6	CACNA1H, CACNA1I, CACNA1G
20	GHRH Signaling36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
21	G-Beta Gamma Signaling36	9.6	CACNA1G, CACNA1I, CACNG3, CACNA1H
22	PKC-Theta Pathway36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
23	NFAT Signaling and Lymphocyte Interactions36	9.6	CACNA1G, CACNA1I, CACNG3, CACNA1H
24	ITK and TCR Signaling36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1G
25	IGF1R Signaling36	9.6	CACNA1G, CACNA1I, CACNG3, CACNA1H
26	Presenilin-Mediated Signaling36	9.5	CACNA1H, CACNG3, CACNA1I, CACNA1G
27	TCR Signaling36	9.5	CACNA1H, CACNG3, CACNA1I, CACNA1G
28	CRHR Pathway36	9.5	CACNA1H, CACNG3, CACNA1I, CACNA1G
29	all-trans-Retinoic Acid Signaling in Brain36	9.5	CACNA1G, CACNA1I, CACNG3, CACNA1H
30	NFAT and Cardiac Hypertrophy36	9.5	CACNA1G, CACNA1I, CACNG3, CACNA1H
31	Chemokine Signaling36	9.5	CACNA1H, CACNG3, CACNA1I, CACNA1G
32	Sweet Taste Signaling36	9.4	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9
33	Melatonin Signaling36	9.4	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9
34	Cellular Effects of Sildenafil36	9.4	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9
35	Signaling Involved in Cardiac Hypertrophy36	9.4	CACNA1G, CACNA1I, CACNG3, CACNA1H
36	Intracellular Calcium Signaling36	9.3	CACNA1H, CACNG3, CACNA1G, GRIK1, CHRNA4
37	IP3 Pathway36	9.3	CACNA1H, CACNG3, CACNA1I, CACNA1G
38	CREB Pathway36	9.3	CACNA1H, CACNG3, CACNA1I, CACNA1G, GRIK1
39	Rap1 Pathway36	9.3	CACNA1G, CACNA1I, CACNG3, CACNA1H
40	MAPK signaling pathway20	9.2	CACNA1G, CACNA1I, CACNG3, CACNA1H
41	GnRH Signaling36	9.1	CACNA1H, CACNG3, CACNA1I, CACNA1G
42	Neuroactive ligand-receptor interaction20	9.1	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1, GRIK1
43	PKA Signaling36	9.1	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9, CLCN2
44	Activation of cAMP-Dependent PKA36	9.0	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9, CLCN2
45	cAMP Pathway36	9.0	CACNA1H, CACNG3, CACNA1I, CACNA1G, KCNK9, CLCN2
46	Sperm Motility36	8.7	KCNK9, GABRB3, GABRA5, GABRA1, GABRG2, CACNA1H

Compounds related to childhood absence epilepsy according to GeneDecks:

(show top 50)    (show all 66)

id	Compound	Score	Top Affiliating Genes
1	Ethchlorvynol9 9	11.1	GABRB3, GABRA5, GABRA1
2	Butalbital9 9	11.1	CHRNA4, GABRA1, GABRA5
3	Heptabarbital9 9	11.1	CHRNA4, GABRA1, GABRA5
4	Metharbital9 9	11.1	CHRNA4, GABRA1, GABRA5
5	Talbutal9 9	11.1	CHRNA4, GABRA1, GABRA5
6	Barbituric acid derivative9 9	11.1	GABRA5, GABRA1, CHRNA4
7	Aprobarbital9 9	11.1	CHRNA4, GABRA1, GABRA5
8	Barbital9 9	11.1	CHRNA4, GABRA1, GABRA5
9	Butabarbital9 9	11.0	CHRNA4, GABRA1, GABRA5
10	Halazepam9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
11	Fludiazepam9 9	11.0	GABRG2, GABRA1, GABRA5, GABRB3
12	Cinolazepam9 9	11.0	GABRG2, GABRA1, GABRA5, GABRB3
13	(+)-bicuculline42	10.0	GABRG2, GABRA1, GABRA5, GABRB3
14	Butethal9 9	11.0	CHRNA4, GABRA1, GABRA5
15	sr 95531 hydrobromide42	10.0	GABRG2, GABRA1, GABRA5, GABRB3
16	Prazepam9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
17	Adinazolam9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
18	estazolam32 9 9	12.0	GABRB3, GABRA5, GABRA1, GABRG2
19	quazepam32 9 9	12.0	GABRB3, GABRA5, GABRA1, GABRG2
20	Clotiazepam9 9	11.0	GABRG2, GABRA1, GABRA5, GABRB3
21	Clorazepate9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
22	Oxazepam9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
23	nitrazepam32 9 9	12.0	GABRB3, GABRA5, GABRA1, GABRG2
24	clobazam34 32 9 9	13.0	GABRB3, GABRA5, GABRA1, GABRG2
25	flurazepam32 9 9	12.0	GABRG2, GABRA1, GABRA5, GABRB3
26	bromazepam32 9 9	12.0	GABRB3, GABRA5, GABRA1, GABRG2
27	Methylphenobarbital9 9	11.0	GABRA5, GABRA1, CHRNA4
28	Temazepam9 9	11.0	GABRB3, GABRA5, GABRA1, GABRG2
29	lorazepam32 34 9 9	13.0	GABRB3, GABRA5, GABRA1, GABRG2
30	amobarbital32 9 9	11.9	GABRA5, GABRA1, CHRNA4
31	chlordiazepoxide32 9 9	11.9	GABRB3, GABRA5, GABRA1, GABRG2
32	triazolam32 9 9	11.9	GABRG2, GABRA1, GABRA5, GABRB3
33	alprazolam32 9 9	11.9	GABRB3, GABRA5, GABRA1, GABRG2
34	Secobarbital9 9	10.9	GABRA5, GABRA1, CHRNA4
35	flunarizine dihydrochloride42	9.8	CACNA1I, CACNA1H, CACNA1G
36	efonidipine hydrochloride monoethanolate42	9.8	CACNA1G, CACNA1I, CACNA1H
37	nnc 55-0396 dihydrochloride42	9.8	CACNA1H, CACNA1G, CACNA1I
38	mibefradil dihydrochloride42	9.8	CACNA1G, CACNA1I, CACNA1H
39	hexobarbital32 9 9	11.8	CHRNA4, GABRA1, GABRA5
40	midazolam32 9 9	11.8	GABRB3, GABRA5, GABRA1, GABRG2
41	l-655,708 42	9.7	GABRB3, GABRA5, GABRG2
42	clonazepam32 9 9	11.6	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1
43	muscimol32 42	10.6	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1
44	chlorine32 18	10.6	CLCN2, GABRG2, GABRA1, GABRA5, GABRB3
45	flunarizine32 9 9	11.6	CACNA1H, CACNA1I, CACNA1G
46	primidone32 9 9	11.5	CHRNA4, GABRA1, GABRA5
47	Cinnarizine9 9	10.5	CACNA1H, CACNA1I, CACNA1G
48	pentobarbital32 9 9	11.3	GABRA5, GABRA1, GABBR1, SLC2A1, CHRNA4
49	diazepam32 34 9 9	12.1	SLC2A1, GABBR1, GABRG2, GABRA1, GABRA5, GABRB3
50	gaba32 42	9.8	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1, SLC2A1

Cellular components related to childhood absence epilepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chloride channel complex	GO:034707	9.3	GABRB3, GABRA5, GABRA1, GABRG2, CLCN2
2	voltage-gated calcium channel complex	GO:005891	9.1	CACNA1H, CACNG3, CACNA1I, CACNA1G
3	integral to plasma membrane	GO:005887	8.9	GABRA5, GABRA1, GABRG2, GABBR1, GRIK1, GABRB3
4	postsynaptic membrane	GO:045211	8.8	CHRNA4, GRIK1, GABBR1, GABRG2, GABRA1, GABRA5
5	cell junction	GO:030054	8.6	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1, GRIK1
6	plasma membrane	GO:005886	7.3	GABRB3, GABRA5, GABRA1, GABRG2, GABBR1, SLC2A1

Biological processes related to childhood absence epilepsy according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission, GABAergic	GO:051932	10.1	GABRG2, GABRA1
2	calcium ion import	GO:070509	9.9	CACNA1G, CACNA1H
3	cochlea development	GO:090102	9.9	KCNK9, GABRA5
4	regulation of membrane potential	GO:042391	9.8	CACNA1H, CACNA1G, CHRNA4
5	ion transmembrane transport	GO:034220	9.7	GABRG2, GABRA1, GABRA5, GABRB3
6	gamma-aminobutyric acid signaling pathway	GO:007214	9.6	GABRA5, GABRA1, GABRG2, GABBR1
7	calcium ion transport	GO:006816	9.3	CHRNA4, CACNA1I, CACNG3
8	transmembrane transport	GO:055085	9.1	GABRB3, GABRA5, GABRA1, GABRG2, SLC2A1
9	transport	GO:006810	8.1	GABRB3, GABRA5, GABRA1, GABRG2, CACNA1H, CACNA1I
10	synaptic transmission	GO:007268	8.0	KCNK9, GABRB3, GABRA5, GABRA1, GABRG2, GABBR1

Molecular functions related to childhood absence epilepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:097110	9.9	CACNA1G, CACNA1H
2	GABA-A receptor activity	GO:004890	9.7	GABRG2, GABRA1, GABRA5, GABRB3
3	extracellular ligand-gated ion channel activity	GO:005230	9.5	GABRB3, GABRA5, GABRA1, GABRG2
4	low voltage-gated calcium channel activity	GO:008332	9.5	CACNA1G, CACNA1I, CACNA1H
5	chloride channel activity	GO:005254	9.3	GABRG2, GABRA1, GABRA5, GABRB3