MCID: CHL109
MIFTS: 32

Childhood Apraxia of Speech malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Childhood Apraxia of Speech

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Aliases & Descriptions for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech 45 51
Developmental Verbal Dyspraxia 45 51
Speech and Language Disorder with Orofacial Dyspraxia 51
Articulation Disorders, Developmental 65
Developmental Apraxia of Speech 45
Apraxia, Developmental Verbal 65
 
Developmental Verbal Apraxia 45
Apraxia, Articulatory 65
Articulatory Apraxia 45
Das 45
Cas 51

Characteristics:

Orphanet epidemiological data:

51
developmental verbal dyspraxia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 209908
UMLS65 C0236828, C3495144, C0750927

Summaries for Childhood Apraxia of Speech

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NIH Rare Diseases:45 Childhood apraxia of speech occurs in children and is present from birth. it appears to be more common in boys than girls. children with this condition have difficulty planning and producing the precise, refined, and specific movements of the tongue, lips, jaw, and palate that are necessary for intelligible speech. the underlying cause is unknown. some researchers believe that childhood apraxia of speech is related to a child's overall language development. others believe it is a neurological disorder that affects the brain's ability to send the proper signals to move the muscles involved in speech. however, brain imaging and other studies have not found evidence of specific brain lesions or differences in brain structure in children with this condition. some children with childhood apraxia of speech have family members who have a history of communication disorders or other learning diaabilities. this observation and recent research findings suggest that genetic factors may play a role. treatment of childhood apraxia of speech involves speech therapy with a speech-language pathologist. those with more severe cases will require more therapy than those with mild cases. the goal of therapy is to increase speech production and intelligibility. in some cases, augmentative and alternative forms of communication may be needed. last updated: 1/4/2016

MalaCards based summary: Childhood Apraxia of Speech, also known as developmental verbal dyspraxia, is related to richieri costa da silva syndrome and pancreatic cancer, and has symptoms including other speech disturbances, specific learning problem and compensatory articulatory substitution. An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include tongue, brain and heart.

Wikipedia:68 Developmental verbal dyspraxia (DVD), also known as childhood apraxia of speech (CAS) and developmental... more...

Related Diseases for Childhood Apraxia of Speech

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Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:



Diseases related to childhood apraxia of speech

Symptoms for Childhood Apraxia of Speech

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UMLS symptoms related to Childhood Apraxia of Speech:


other speech disturbances, specific learning problem, compensatory articulatory substitution, aprosodia

Drugs & Therapeutics for Childhood Apraxia of Speech

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Stuttering and Apraxia of Speech: the Efficacy of an Intervention ProgramCompletedNCT01097161

Search NIH Clinical Center for Childhood Apraxia of Speech

Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

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MalaCards organs/tissues related to Childhood Apraxia of Speech:

33
Tongue, Brain, Heart, Prostate, Breast, T cells, B cells

Animal Models for Childhood Apraxia of Speech or affiliated genes

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Publications for Childhood Apraxia of Speech

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Articles related to Childhood Apraxia of Speech:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. (27120335)
2016
2
Telehealth delivery of Rapid Syllable Transitions (ReST) treatment for childhood apraxia of speech. (27161038)
2016
3
Expanding the phenotypic profile of Kleefstra syndrome: A female with low-average intelligence and childhood apraxia of speech. (26833960)
2016
4
Volubility, consonant, and syllable characteristics in infants and toddlers later diagnosed with childhood apraxia of speech: A pilot study. (25934424)
2015
5
Oral Articulatory Control in Childhood Apraxia of Speech. (25951237)
2015
6
Differential diagnosis of children with suspected childhood apraxia of speech. (25480674)
2015
7
A Randomized Controlled Trial for children with Childhood Apraxia of Speech comparing Rapid Syllable Transition Treatment and the Nuffield Dyspraxia Programme (3rd edition). (25807891)
2015
8
Treatment intensity and childhood apraxia of speech. (25581372)
2015
9
The role of candidate-gene CNTNAP2 in childhood apraxia of speech and specific language impairment. (26097074)
2015
10
Cognitive functions in Childhood Apraxia of Speech. (25675214)
2015
11
Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children. (26552038)
2015
12
Orthographically sensitive treatment for dysprosody in children with childhood apraxia of speech using ReST intervention. (24694312)
2014
13
Motor-based intervention protocols in treatment of childhood apraxia of speech (CAS). (25313348)
2014
14
Impact of speech-generating devices on the language development of a child with childhood apraxia of speech: a case study. (24773213)
2014
15
Ultrasound biofeedback treatment for persisting childhood apraxia of speech. (23813207)
2013
16
Treating speech subsystems in childhood apraxia of speech with tactual input: the PROMPT approach. (23813194)
2013
17
Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech. (23339324)
2013
18
Dual copy number variants involving 16p11 and 6q22 in a case of childhood apraxia of speech and pervasive developmental disorder. (22909776)
2013
19
Early development in infants at risk of childhood apraxia of speech: a longitudinal investigation. (23573797)
2013
20
Associations among measures of sequential processing in motor and linguistics tasks in adults with and without a family history of childhood apraxia of speech: a replication study. (23339292)
2013
21
Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. (24083349)
2013
22
Associations between caregiving, social support, and well-being among parents of children with childhood apraxia of speech. (22928745)
2013
23
Childhood Apraxia of Speech (CAS) in two patients with 16p11.2 microdeletion syndrome. (22909774)
2013
24
Childhood apraxia of speech without intellectual deficit in a patient with cri du chat syndrome. (22510527)
2012
25
Prelinguistic communication development in children with childhood apraxia of speech: a retrospective analysis. (22257070)
2012
26
Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. (22766611)
2012
27
Mismatch negativity responses in children with a diagnosis of childhood apraxia of speech (CAS). (22564903)
2012
28
Encoding, memory, and transcoding deficits in Childhood Apraxia of Speech. (22489736)
2012
29
Random versus blocked practice in treatment for childhood apraxia of speech. (22207698)
2012
30
Clear as mud: another look at autism, childhood apraxia of speech and auditory processing. (22450249)
2012
31
The importance of production frequency in therapy for childhood apraxia of speech. (21330650)
2011
32
Lexical and phonological development in children with childhood apraxia of speech--a commentary on Stoel-Gammon's 'Relationships between lexical and phonological development in young children'. (20950498)
2011
33
Prevalence and phenotype of childhood apraxia of speech in youth with galactosemia. (20966389)
2011
34
Aerodynamic indices of velopharyngeal function in childhood apraxia of speech. (20136498)
2010
35
Through the magnifying glass: Underlying literacy deficits and remediation potential in childhood apraxia of speech. (20380250)
2010
36
Childhood apraxia of speech and multiple phonological disorders in Cairo-Egyptian Arabic speaking children: language, speech, and oro-motor differences. (20202694)
2010
37
Speech motor development in childhood apraxia of speech: generating testable hypotheses by neurocomputational modeling. (20424469)
2010
38
A Cochrane review of treatment for childhood apraxia of speech. (19156019)
2009
39
Results of the Sensory Profile in children with suspected childhood apraxia of speech. (19401932)
2009
40
Computational neural modeling of speech motor control in childhood apraxia of speech (CAS). (19951927)
2009
41
Phonological awareness and early reading development in childhood apraxia of speech (CAS). (19234970)
2009
42
Treatment of childhood apraxia of speech: clinical decision making in the use of nonspeech oral motor exercises. (19058115)
2008
43
Breakpoint localization using array-CGH in three siblings with an unbalanced 4q;16q translocation and childhood apraxia of speech (CAS). (18671280)
2008
44
Childhood apraxia of speech: children at risk for persistent reading and spelling disorder. (17340382)
2007
45
Consonant and syllable structure patterns in childhood apraxia of speech: developmental change in three children. (16469328)
2006
46
Phonological awareness intervention for children with childhood apraxia of speech. (17079224)
2006
47
School-age follow-up of children with childhood apraxia of speech. (15191325)
2004
48
Diagnostic Assessment of Childhood Apraxia of Speech Using Automatic Speech Recognition (ASR) Methods. (17066124)
2004
49
A diagnostic marker for childhood apraxia of speech: the coefficient of variation ratio. (14608800)
2003
50
A diagnostic marker for childhood apraxia of speech: the lexical stress ratio. (14608799)
2003

Variations for Childhood Apraxia of Speech

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Expression for genes affiliated with Childhood Apraxia of Speech

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Search GEO for disease gene expression data for Childhood Apraxia of Speech.

Pathways for genes affiliated with Childhood Apraxia of Speech

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GO Terms for genes affiliated with Childhood Apraxia of Speech

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Sources for Childhood Apraxia of Speech

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet