MCID: CHL109
MIFTS: 27

Childhood Apraxia of Speech malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Childhood Apraxia of Speech

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Aliases & Descriptions for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech 51
Speech and Language Disorder with Orofacial Dyspraxia 51
 
Developmental Verbal Dyspraxia 51
Cas 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
speech and language disorder with orofacial dyspraxia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy


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Orphanet51 209908

Summaries for Childhood Apraxia of Speech

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Wikipedia:68 Developmental verbal dyspraxia (DVD), also known as childhood apraxia of speech (CAS) and developmental... more...

MalaCards based summary: Childhood Apraxia of Speech, also known as speech and language disorder with orofacial dyspraxia, is related to apraxia and breast cancer. An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include tongue and brain, and related mouse phenotype no phenotypic analysis.

Related Diseases for Childhood Apraxia of Speech

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Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:



Diseases related to childhood apraxia of speech

Symptoms for Childhood Apraxia of Speech

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Drugs & Therapeutics for Childhood Apraxia of Speech

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Apraxia of Speech: Comparison of EPG Treatment (Tx) and Sound Production Treatment (SPT)Not yet recruitingNCT02554513Phase 1
2Central Mechanisms in Speech Motor Control Studied With H215O PETCompletedNCT00001308

Search NIH Clinical Center for Childhood Apraxia of Speech

Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

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MalaCards organs/tissues related to Childhood Apraxia of Speech:

33
Tongue, Brain

Animal Models for Childhood Apraxia of Speech or affiliated genes

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MGI Mouse Phenotypes related to Childhood Apraxia of Speech:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1ERC1, FOXP2

Publications for Childhood Apraxia of Speech

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Articles related to Childhood Apraxia of Speech:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Volubility, consonant, and syllable characteristics in infants and toddlers later diagnosed with childhood apraxia of speech: A pilot study. (25934424)
2015
2
Oral Articulatory Control in Childhood Apraxia of Speech. (25951237)
2015
3
Differential diagnosis of children with suspected childhood apraxia of speech. (25480674)
2015
4
A Randomized Controlled Trial for children with Childhood Apraxia of Speech comparing Rapid Syllable Transition Treatment and the Nuffield Dyspraxia Programme (3rd edition). (25807891)
2015
5
Treatment intensity and childhood apraxia of speech. (25581372)
2015
6
The role of candidate-gene CNTNAP2 in childhood apraxia of speech and specific language impairment. (26097074)
2015
7
Cognitive functions in Childhood Apraxia of Speech. (25675214)
2015
8
Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children. (26552038)
2015
9
Orthographically sensitive treatment for dysprosody in children with childhood apraxia of speech using ReST intervention. (24694312)
2014
10
Motor-based intervention protocols in treatment of childhood apraxia of speech (CAS). (25313348)
2014
11
Impact of speech-generating devices on the language development of a child with childhood apraxia of speech: a case study. (24773213)
2014
12
Using randomized variable practice in the treatment of childhood apraxia of speech. (25017177)
2014
13
Ultrasound biofeedback treatment for persisting childhood apraxia of speech. (23813207)
2013
14
Treating speech subsystems in childhood apraxia of speech with tactual input: the PROMPT approach. (23813194)
2013
15
Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech. (23339324)
2013
16
Dual copy number variants involving 16p11 and 6q22 in a case of childhood apraxia of speech and pervasive developmental disorder. (22909776)
2013
17
Early development in infants at risk of childhood apraxia of speech: a longitudinal investigation. (23573797)
2013
18
Associations among measures of sequential processing in motor and linguistics tasks in adults with and without a family history of childhood apraxia of speech: a replication study. (23339292)
2013
19
Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. (24083349)
2013
20
Associations between caregiving, social support, and well-being among parents of children with childhood apraxia of speech. (22928745)
2013
21
Childhood Apraxia of Speech (CAS) in two patients with 16p11.2 microdeletion syndrome. (22909774)
2013
22
Childhood apraxia of speech without intellectual deficit in a patient with cri du chat syndrome. (22510527)
2012
23
Prelinguistic communication development in children with childhood apraxia of speech: a retrospective analysis. (22257070)
2012
24
Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. (22766611)
2012
25
Mismatch negativity responses in children with a diagnosis of childhood apraxia of speech (CAS). (22564903)
2012
26
Encoding, memory, and transcoding deficits in Childhood Apraxia of Speech. (22489736)
2012
27
Random versus blocked practice in treatment for childhood apraxia of speech. (22207698)
2012
28
Clear as mud: another look at autism, childhood apraxia of speech and auditory processing. (22450249)
2012
29
The importance of production frequency in therapy for childhood apraxia of speech. (21330650)
2011
30
Lexical and phonological development in children with childhood apraxia of speech--a commentary on Stoel-Gammon's 'Relationships between lexical and phonological development in young children'. (20950498)
2011
31
Prevalence and phenotype of childhood apraxia of speech in youth with galactosemia. (20966389)
2011
32
Aerodynamic indices of velopharyngeal function in childhood apraxia of speech. (20136498)
2010
33
Through the magnifying glass: Underlying literacy deficits and remediation potential in childhood apraxia of speech. (20380250)
2010
34
Childhood apraxia of speech and multiple phonological disorders in Cairo-Egyptian Arabic speaking children: language, speech, and oro-motor differences. (20202694)
2010
35
Speech motor development in childhood apraxia of speech: generating testable hypotheses by neurocomputational modeling. (20424469)
2010
36
Evaluation of a combined treatment approach for childhood apraxia of speech. (20345262)
2010
37
A treatment for dysprosody in childhood apraxia of speech. (20798323)
2010
38
A Cochrane review of treatment for childhood apraxia of speech. (19156019)
2009
39
Results of the Sensory Profile in children with suspected childhood apraxia of speech. (19401932)
2009
40
Computational neural modeling of speech motor control in childhood apraxia of speech (CAS). (19951927)
2009
41
Phonological awareness and early reading development in childhood apraxia of speech (CAS). (19234970)
2009
42
Treatment of childhood apraxia of speech: clinical decision making in the use of nonspeech oral motor exercises. (19058115)
2008
43
Breakpoint localization using array-CGH in three siblings with an unbalanced 4q;16q translocation and childhood apraxia of speech (CAS). (18671280)
2008
44
Childhood apraxia of speech: children at risk for persistent reading and spelling disorder. (17340382)
2007
45
Consonant and syllable structure patterns in childhood apraxia of speech: developmental change in three children. (16469328)
2006
46
Phonological awareness intervention for children with childhood apraxia of speech. (17079224)
2006
47
School-age follow-up of children with childhood apraxia of speech. (15191325)
2004
48
Diagnostic Assessment of Childhood Apraxia of Speech Using Automatic Speech Recognition (ASR) Methods. (17066124)
2004
49
A diagnostic marker for childhood apraxia of speech: the coefficient of variation ratio. (14608800)
2003
50
A diagnostic marker for childhood apraxia of speech: the lexical stress ratio. (14608799)
2003

Variations for Childhood Apraxia of Speech

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Clinvar genetic disease variations for Childhood Apraxia of Speech:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FOXP2NM_148898.3(FOXP2): c.1733G> A (p.Arg578His)single nucleotide variantPathogenicrs121908377GRCh37Chr 7, 114302130: 114302130
2FOXP2NM_148898.3(FOXP2): c.1057C> T (p.Arg353Ter)single nucleotide variantPathogenicrs121908378GRCh37Chr 7, 114282671: 114282671

Expression for genes affiliated with Childhood Apraxia of Speech

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Search GEO for disease gene expression data for Childhood Apraxia of Speech.

Pathways for genes affiliated with Childhood Apraxia of Speech

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GO Terms for genes affiliated with Childhood Apraxia of Speech

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Biological processes related to Childhood Apraxia of Speech according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription, DNA-templatedGO:00063559.1ERC1, FOXP2

Sources for Childhood Apraxia of Speech

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet