MCID: CHL109
MIFTS: 25

Childhood Apraxia of Speech malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Childhood Apraxia of Speech

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Aliases & Descriptions for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech 45 51
Developmental Verbal Dyspraxia 45 51
Speech and Language Disorder with Orofacial Dyspraxia 51
Articulation Disorders, Developmental 65
Developmental Apraxia of Speech 45
Apraxia, Developmental Verbal 65
 
Developmental Verbal Apraxia 45
Apraxia, Articulatory 65
Articulatory Apraxia 45
Das 45
Cas 51

Characteristics:

Orphanet epidemiological data:

51
developmental verbal dyspraxia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 209908
UMLS65 C0236828, C3495144, C0750927

Summaries for Childhood Apraxia of Speech

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NIH Rare Diseases:45 Childhood apraxia of speech occurs in children and is present from birth. it appears to be more common in boys than girls. children with this condition have difficulty planning and producing the precise, refined, and specific movements of the tongue, lips, jaw, and palate that are necessary for intelligible speech. the underlying cause is unknown. some researchers believe that childhood apraxia of speech is related to a child's overall language development. others believe it is a neurological disorder that affects the brain's ability to send the proper signals to move the muscles involved in speech. however, brain imaging and other studies have not found evidence of specific brain lesions or differences in brain structure in children with this condition. some children with childhood apraxia of speech have family members who have a history of communication disorders or other learning diaabilities. this observation and recent research findings suggest that genetic factors may play a role. treatment of childhood apraxia of speech involves speech therapy with a speech-language pathologist. those with more severe cases will require more therapy than those with mild cases. the goal of therapy is to increase speech production and intelligibility. in some cases, augmentative and alternative forms of communication may be needed. last updated: 1/4/2016

MalaCards based summary: Childhood Apraxia of Speech, also known as developmental verbal dyspraxia, is related to richieri costa da silva syndrome and erythrokeratodermia variabilis et progressiva. An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include tongue, brain and breast.

Wikipedia:68 Developmental verbal dyspraxia (DVD), also known as childhood apraxia of speech (CAS) and developmental... more...

Related Diseases for Childhood Apraxia of Speech

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Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:



Diseases related to childhood apraxia of speech

Symptoms for Childhood Apraxia of Speech

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Drugs & Therapeutics for Childhood Apraxia of Speech

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Stuttering and Apraxia of Speech: the Efficacy of an Intervention ProgramCompletedNCT01097161

Search NIH Clinical Center for Childhood Apraxia of Speech

Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

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MalaCards organs/tissues related to Childhood Apraxia of Speech:

33
Tongue, Brain, Breast, T cells, Lung, Bone, B cells

Animal Models for Childhood Apraxia of Speech or affiliated genes

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Publications for Childhood Apraxia of Speech

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Articles related to Childhood Apraxia of Speech:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. (26183516)
2015
2
Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment. (26386811)
2015
3
Long-term disease control and toxicity outcomes following surgery and intensity modulated radiation therapy (IMRT) in pediatric craniopharyngioma. (25542650)
2015
4
Linear nevus sebaceous syndrome. (25506177)
2014
5
Multiple myeloma maintenance therapy: A review of the pharmacologic treatment. (24395544)
2014
6
Syncytin-1 and its receptor is present in human gametes. (24687878)
2014
7
Is there something called adult onset atopic dermatitis in India? (23442451)
2013
8
Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). (24054860)
2013
9
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection. (24026329)
2013
10
Dual-energy CT angiography for assessment of regional pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: initial experience. (21343493)
2011
11
Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells. (21116120)
2010
12
Sapropterin. Phenylketonuria: for a minority of patients. (20738029)
2010
13
Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization. (19638589)
2009
14
Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. (18607617)
2008
15
Freezing point depression of water in phospholipid membranes: a solid-state NMR study. (18991419)
2008
16
Contribution of gluconeogenesis and glycogenolysis to hepatic glucose production in acromegaly before and after pituitary microsurgery. (18393170)
2008
17
Optic neuritis due to solvent abuse. (18392432)
2008
18
Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri. (18762406)
2008
19
Wood charcoal and activated carbon dust pneumoconiosis in three workers. (17315177)
2007
20
Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis. (17880530)
2007
21
Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. (17606223)
2007
22
Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha). (16769036)
2006
23
Signal transduction in natural killer cells. (16329184)
2006
24
Granular cell tumor of the scrotum. (16150233)
2005
25
Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases. (15987446)
2005
26
G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. (15843435)
2005
27
Spontaneous apical lung herniation presenting as a neck lump in a patient with Ehlers-Danlos syndrome. (15789797)
2005
28
Humoral immune response in prostate cancer patients after immunization with gene-based vaccines that encode for a protein that is proteasomally degraded. (15641767)
2005
29
Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. (15004007)
2004
30
A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida. (15211708)
2004
31
Coordinated diagnostic approach for adult obstructive lung disease in primary care. (16701672)
2004
32
Possible influence of glutathione S-transferase GSTT1 null genotype on age of onset of sporadic colorectal adenocarcinoma. (12682546)
2003
33
Possible role of DNA hypomethylation in the induction of SLE: relationship to the transcription of human endogenous retroviruses. (14740452)
2003
34
Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. (12815195)
2003
35
Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication. (11956210)
2002
36
Phase II study of a high-dose ifosfamide-based chemotherapy regimen with growth factor rescue in recurrent aggressive NHL. High response rates and limited toxicity, but limited impact on long-term survival. (11313669)
2001
37
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate. (11763416)
2001
38
Human recombinant anti-HER2 monoclonal antibody--a new targeted treatment in breast cancer]. (11770175)
2001
39
Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? (9769134)
1998
40
Expression of Epstein-Barr virus BMRF-2 and BDLF-3 genes in hairy leukoplakia. (9400989)
1997
41
Decreased beta2-adrenergic receptor density on peripheral blood mononuclear cells in myasthenia gravis. (9237804)
1997
42
A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels. (8612769)
1996
43
Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. (8738722)
1996
44
Patient-administered sequential spirometry in healthy volunteers and patients with alpha 1-antitrypsin deficiency. (8736204)
1996
45
Interferon-gamma-stimulated and GTP-binding-proteins-mediated phospholipase A2 activation in human neuroblasts. (8397512)
1993
46
Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes. (8432768)
1993
47
Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1. (8507218)
1993
48
Characterization of the progression signal for human T-cell proliferation provided by monoclonal antibodies to the CD3-TCR complex. (8500271)
1993
49
Expression of T cell receptors alpha beta and gamma delta in the ileal mucosa of patients with Crohn's disease and with spondylarthropathy. (1424287)
1992
50
Puerperal Fever: In What Way It May Originate from Erysipelas, and How Communicable. (20794391)
1848

Variations for Childhood Apraxia of Speech

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Expression for genes affiliated with Childhood Apraxia of Speech

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Search GEO for disease gene expression data for Childhood Apraxia of Speech.

Pathways for genes affiliated with Childhood Apraxia of Speech

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GO Terms for genes affiliated with Childhood Apraxia of Speech

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Sources for Childhood Apraxia of Speech

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet