MCID: CHL109
MIFTS: 26

Childhood Apraxia of Speech malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Childhood Apraxia of Speech

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Aliases & Descriptions for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech 47 53
Developmental Verbal Dyspraxia 47 53
Speech and Language Disorder with Orofacial Dyspraxia 53
Articulation Disorders, Developmental 67
Developmental Apraxia of Speech 47
Apraxia, Developmental Verbal 67
 
Developmental Verbal Apraxia 47
Apraxia, Articulatory 67
Articulatory Apraxia 47
Das 47
Cas 53

Characteristics:

Orphanet epidemiological data:

53
developmental verbal dyspraxia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet53 ORPHA209908

Summaries for Childhood Apraxia of Speech

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MalaCards based summary: Childhood Apraxia of Speech, also known as developmental verbal dyspraxia, is related to richieri costa da silva syndrome and foxp2-related speech and language disorders, and has symptoms including aprosodia, compensatory articulatory substitution and specific learning problem. An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2).

Related Diseases for Childhood Apraxia of Speech

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Diseases related to Childhood Apraxia of Speech via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1richieri costa da silva syndrome11.8
2foxp2-related speech and language disorders11.7
3scott syndrome11.2
4gastric cancer11.2
5pancreatic cancer11.2
6spinocerebellar ataxia 3611.1
7erythrokeratodermia variabilis et progressiva11.0
8myotonia with skeletal abnormalities and mental retardation10.9
9intellectual disability - hypoplastic corpus callosum - preauricular tag10.9
10apraxia10.8
11arthrogryposis, distal, type 2b10.8
12arthrogryposis, distal, type 510.8
13amyloidosis, hereditary, transthyretin-related10.8
14occipital horn syndrome10.8
15phosphohydroxylysinuria10.8
16orthostatic intolerance10.7
17daneman davy mancer syndrome10.7
18allergic encephalomyelitis9.9
19leukemia9.9
20mutism9.9CNTNAP2, FOXP2
21galactosemia9.8
22kleefstra syndrome9.8
23cri-du-chat syndrome9.8
24sleep apnea9.8
25obstructive sleep apnea9.8
26pervasive developmental disorder9.8
27specific language impairment9.8
28neuronitis9.8
29scoliosis9.8CNTNAP2, FOXP2
30meningitis9.8
31tinea manuum9.8CNTNAP2, FOXP2
32acne9.7
33arthritis9.7
34aseptic meningitis9.7
35periodic limb movement disorder9.7CNTNAP2, FOXP2
36sexual disorder9.7CNTNAP2, FOXP2
37pheochromocytoma9.6
38atopy9.6
39asthma9.6
40birdshot chorioretinopathy9.6
41mumps9.6
42megaesophagus9.6
43acute pancreatitis9.6
44pancreatitis9.6
45diabetic macular edema9.6
46allergic asthma9.6
47cardiomyopathy9.6
48ataxia9.6
49endotheliitis9.6
50tendinopathy9.6CNTNAP2, FOXP2

Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:



Diseases related to childhood apraxia of speech

Symptoms for Childhood Apraxia of Speech

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UMLS symptoms related to Childhood Apraxia of Speech:


aprosodia, compensatory articulatory substitution, specific learning problem, other speech disturbances

Drugs & Therapeutics for Childhood Apraxia of Speech

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Stuttering and Apraxia of Speech: the Efficacy of an Intervention ProgramCompletedNCT01097161
2Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168

Search NIH Clinical Center for Childhood Apraxia of Speech

Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

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Animal Models for Childhood Apraxia of Speech or affiliated genes

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Publications for Childhood Apraxia of Speech

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Articles related to Childhood Apraxia of Speech:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach. (27882295)
2016
2
Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. (27120335)
2016
3
A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2. (26763793)
2016
4
Articulatory Control in Childhood Apraxia of Speech in a Novel Word-Learning Task. (27750297)
2016
5
Childhood apraxia of speech: A survey of praxis and typical speech characteristics. (27241138)
2016
6
Telehealth delivery of Rapid Syllable Transitions (ReST) treatment for childhood apraxia of speech. (27161038)
2016
7
Oral Articulatory Control in Childhood Apraxia of Speech. (25951237)
2015
8
Differential diagnosis of children with suspected childhood apraxia of speech. (25480674)
2015
9
Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children. (26552038)
2015
10
Reliance on auditory feedback in children with childhood apraxia of speech. (25662298)
2015
11
Simultaneous natural speech and AAC interventions for children with childhood apraxia of speech: lessons from a speech-language pathologist focus group. (25664542)
2015
12
Volubility, consonant, and syllable characteristics in infants and toddlers later diagnosed with childhood apraxia of speech: A pilot study. (25934424)
2015
13
A Randomized Controlled Trial for children with Childhood Apraxia of Speech comparing Rapid Syllable Transition Treatment and the Nuffield Dyspraxia Programme (3rd edition). (25807891)
2015
14
Treatment intensity and childhood apraxia of speech. (25581372)
2015
15
Motor-based intervention protocols in treatment of childhood apraxia of speech (CAS). (25313348)
2014
16
Rapid Syllable Transitions (ReST) treatment for Childhood Apraxia of Speech: The effect of lower dose-Frequency. (25052390)
2014
17
A systematic review of treatment outcomes for children with childhood apraxia of speech. (24686844)
2014
18
Orthographically sensitive treatment for dysprosody in children with childhood apraxia of speech using ReST intervention. (24694312)
2014
19
Ultrasound biofeedback treatment for persisting childhood apraxia of speech. (23813207)
2013
20
Treating speech subsystems in childhood apraxia of speech with tactual input: the PROMPT approach. (23813194)
2013
21
Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech. (23339324)
2013
22
Associations among measures of sequential processing in motor and linguistics tasks in adults with and without a family history of childhood apraxia of speech: a replication study. (23339292)
2013
23
Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. (24083349)
2013
24
Childhood apraxia of speech without intellectual deficit in a patient with cri du chat syndrome. (22510527)
2012
25
Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. (22766611)
2012
26
Mismatch negativity responses in children with a diagnosis of childhood apraxia of speech (CAS). (22564903)
2012
27
Feedback frequency in treatment for childhood apraxia of speech. (22442284)
2012
28
A comparison of two treatments for childhood apraxia of speech: methods and treatment protocol for a parallel group randomised control trial. (22863021)
2012
29
Prelinguistic communication development in children with childhood apraxia of speech: a retrospective analysis. (22257070)
2012
30
The importance of production frequency in therapy for childhood apraxia of speech. (21330650)
2011
31
Prevalence and phenotype of childhood apraxia of speech in youth with galactosemia. (20966389)
2011
32
Lexical and phonological development in children with childhood apraxia of speech--a commentary on Stoel-Gammon's 'Relationships between lexical and phonological development in young children'. (20950498)
2011
33
Childhood apraxia of speech and multiple phonological disorders in Cairo-Egyptian Arabic speaking children: language, speech, and oro-motor differences. (20202694)
2010
34
Speech motor development in childhood apraxia of speech: generating testable hypotheses by neurocomputational modeling. (20424469)
2010
35
Aerodynamic indices of velopharyngeal function in childhood apraxia of speech. (20136498)
2010
36
Through the magnifying glass: Underlying literacy deficits and remediation potential in childhood apraxia of speech. (20380250)
2010
37
A Cochrane review of treatment for childhood apraxia of speech. (19156019)
2009
38
Results of the Sensory Profile in children with suspected childhood apraxia of speech. (19401932)
2009
39
Treatment of childhood apraxia of speech: clinical decision making in the use of nonspeech oral motor exercises. (19058115)
2008
40
Breakpoint localization using array-CGH in three siblings with an unbalanced 4q;16q translocation and childhood apraxia of speech (CAS). (18671280)
2008
41
Obstructive sleep apnea, seizures, and childhood apraxia of speech. (18486825)
2008
42
Childhood apraxia of speech: children at risk for persistent reading and spelling disorder. (17340382)
2007
43
Consonant and syllable structure patterns in childhood apraxia of speech: developmental change in three children. (16469328)
2006
44
Phonological awareness intervention for children with childhood apraxia of speech. (17079224)
2006
45
Timing errors in two children with suspected childhood apraxia of speech (sCAS) during speech and music-related tasks. (15704499)
2005
46
Diagnostic Assessment of Childhood Apraxia of Speech Using Automatic Speech Recognition (ASR) Methods. (17066124)
2004
47
Family pedigrees of children with suspected childhood apraxia of speech. (15013731)
2004
48
School-age follow-up of children with childhood apraxia of speech. (15191325)
2004
49
A diagnostic marker for childhood apraxia of speech: the lexical stress ratio. (14608799)
2003
50
A diagnostic marker for childhood apraxia of speech: the coefficient of variation ratio. (14608800)
2003

Variations for Childhood Apraxia of Speech

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Expression for genes affiliated with Childhood Apraxia of Speech

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Search GEO for disease gene expression data for Childhood Apraxia of Speech.

Pathways for genes affiliated with Childhood Apraxia of Speech

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GO Terms for genes affiliated with Childhood Apraxia of Speech

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Biological processes related to Childhood Apraxia of Speech according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex developmentGO:00219879.0CNTNAP2, FOXP2
2vocal learningGO:00422978.9CNTNAP2, FOXP2

Sources for Childhood Apraxia of Speech

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet