MCID: CHL010
MIFTS: 33

Childhood Kidney Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Childhood Kidney Cell Carcinoma

MalaCards integrated aliases for Childhood Kidney Cell Carcinoma:

Name: Childhood Kidney Cell Carcinoma 12 14
Pediatric Renal Cell Carcinoma 12
Childhood Renal Cell Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4454
NCIt 47 C6568
UMLS 69 C1333001

Summaries for Childhood Kidney Cell Carcinoma

MalaCards based summary : Childhood Kidney Cell Carcinoma, also known as pediatric renal cell carcinoma, is related to waardenburg syndrome/ocular albinism, digenic and large intestine adenocarcinoma, and has symptoms including flank pain An important gene associated with Childhood Kidney Cell Carcinoma is TPM3 (Tropomyosin 3), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related phenotypes are cellular and mortality/aging

Related Diseases for Childhood Kidney Cell Carcinoma

Diseases related to Childhood Kidney Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 waardenburg syndrome/ocular albinism, digenic 10.6 MITF TFE3
2 large intestine adenocarcinoma 10.6 MLH1 MSH2
3 optic nerve sheath meningioma 10.6 MLH1 MSH2
4 benign fibrous mesothelioma 10.6 MLH1 MSH2
5 psoriasis 10.6 MLH1 MSH2
6 cataract 27, nuclear progressive 10.6 MLH1 MSH2
7 waardenburg syndrome, type 3 10.6 MITF PAX3
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 MLH1 MSH2
9 angelman syndrome due to a point mutation 10.5 MITF TFE3
10 melanoma, cutaneous malignant 8 10.5 MITF PAX3
11 thyroid gland disease 10.5 MLH1 MSH2
12 mismatch repair cancer syndrome 10.4 MLH1 MSH2 PAX3
13 y-linked disease 10.4 MLH1 MSH2 PAX3
14 lymphoplasmacytic lymphoma 10.4 MLH1 MSH2 TSC2
15 eccrine papillary adenocarcinoma 10.3 ALK EML4
16 tyrosinemia 10.3 MITF PAX3 TFE3
17 melanocytic nevus syndrome, congenital, somatic 10.3 MLH1 MSH2
18 mixed extragonadal germ cell cancer 10.3 ALK EML4 TPM3
19 46xy sex reversal 5 10.2 ASPSCR1 MLH1 TFE3
20 neurofibromatosis, familial spinal 10.1 MLH1 MSH2 TSC2
21 biliary papillomatosis 10.1 MITF PAX3
22 breast adenoid cystic carcinoma 10.0 ALK EML4
23 malignant biphasic mesothelioma 10.0 PRCC TFE3
24 renal cell carcinoma 9.9
25 central nervous system rhabdomyosarcoma 9.8 FOXO1 PAX3 TFE3
26 mediastinum rhabdomyosarcoma 9.4 ASPSCR1 FOXO1 PAX3 TFE3
27 renal cell carcinoma, papillary 9.4 ASPSCR1 MITF PRCC TFE3 TFEB
28 bernard-soulier syndrome, type c 8.9 ASPSCR1 MITF PAX2 PRCC TFE3 TFEB
29 multilocular clear cell renal cell carcinoma 4.6 ALK ASPSCR1 EML4 F3 FOXO1 GPX7

Graphical network of the top 20 diseases related to Childhood Kidney Cell Carcinoma:



Diseases related to Childhood Kidney Cell Carcinoma

Symptoms & Phenotypes for Childhood Kidney Cell Carcinoma

UMLS symptoms related to Childhood Kidney Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Childhood Kidney Cell Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 F3 FOXO1 GPX7 MITF MLH1 MSH2
2 mortality/aging MP:0010768 10.1 ALK F3 FOXO1 GPX7 MITF MLH1
3 integument MP:0010771 10.02 PAX3 TFE3 TFEB TSC2 ALK F3
4 embryo MP:0005380 9.97 F3 FOXO1 MITF PAX2 PAX3 TFEB
5 neoplasm MP:0002006 9.76 ALK F3 FOXO1 GPX7 MLH1 MSH2
6 pigmentation MP:0001186 9.43 PAX3 TFE3 TFEB ALK MITF PAX2
7 vision/eye MP:0005391 9.23 ALK F3 MITF MLH1 PAX2 PAX3

Drugs & Therapeutics for Childhood Kidney Cell Carcinoma

Drugs for Childhood Kidney Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
4
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
5
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
6
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
7
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
8
Sulfamethoxazole Approved Phase 3 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
10
Doxil Approved June 1999 Phase 3,Phase 2 31703
11 Alkylating Agents Phase 3,Phase 2,Phase 1
12 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14 Anti-Infective Agents Phase 3,Phase 2,Phase 1
15 Antimitotic Agents Phase 3,Phase 2
16 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
17 Antirheumatic Agents Phase 3,Phase 2,Phase 1
18 Etoposide phosphate Phase 3,Phase 2,Phase 1
19 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
20 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Adjuvants, Immunologic Phase 3,Phase 1
23
Melphalan Approved Phase 2,Phase 1 148-82-3 4053 460612
24
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
25
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
26
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
27
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
28 Thiotepa Approved Phase 2,Phase 1 52-24-4 5453
29
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
30
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
31
Vidarabine Approved Phase 1, Phase 2 24356-66-9 32326 21704
32
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
33
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
34
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
35
Camptothecin Experimental Phase 2 7689-03-4
36
Docetaxel Approved May 1996, Investigational Phase 1, Phase 2 114977-28-5 148124 9877265
37 Antimetabolites Phase 1, Phase 2
38 Antimetabolites, Antineoplastic Phase 1, Phase 2
39 Calcineurin Inhibitors Phase 1, Phase 2
40 Dermatologic Agents Phase 1, Phase 2
41 topoisomerase I inhibitors Phase 2
42 Androgens Phase 1, Phase 2
43 Liver Extracts Phase 2,Phase 1
44 Antifungal Agents Phase 1, Phase 2
45 Antiviral Agents Phase 1, Phase 2
46 Cyclosporins Phase 1, Phase 2
47 Vidarabine Phosphate Phase 1, Phase 2
48 Isophosphamide mustard Phase 1, Phase 2
49 Protein Kinase Inhibitors Phase 1, Phase 2
50 Cola Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney Unknown status NCT00025103 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;melphalan;vincristine sulfate
3 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
4 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
5 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
6 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Active, not recruiting NCT00027820 Phase 1, Phase 2 Fludarabine Phosphate;Cyclosporine;Mycophenolate Mofetil
7 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
8 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
9 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
10 Vaccine Trial for Clear Cell Sarcoma, Pediatric Renal Cell Carcinoma, Alveolar Soft Part Sarcoma and Children With Stage IV Melanoma Active, not recruiting NCT00258687 Phase 1
11 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
12 A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors Withdrawn NCT01182883 Phase 1 IMC-A12;Temsirolimus
13 Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia Unknown status NCT00295997 busulfan;cyclophosphamide;fludarabine phosphate;methotrexate;mycophenolate mofetil;tacrolimus
14 Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Active, not recruiting NCT00005799 fludarabine phosphate;cyclosporine;mycophenolate mofetil
15 Studying Tumor Tissue Samples From Patients Who Have Undergone Surgery for Localized Kidney Cancer Withdrawn NCT00908739
16 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095

Search NIH Clinical Center for Childhood Kidney Cell Carcinoma

Genetic Tests for Childhood Kidney Cell Carcinoma

Anatomical Context for Childhood Kidney Cell Carcinoma

MalaCards organs/tissues related to Childhood Kidney Cell Carcinoma:

39
Kidney, Liver, Bone, Bone Marrow

Publications for Childhood Kidney Cell Carcinoma

Variations for Childhood Kidney Cell Carcinoma

Cosmic variations for Childhood Kidney Cell Carcinoma:

9 (show all 21)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM25676 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 6
2 COSM27269 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176L 6
3 COSM30474 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 6
4 COSM26594 RNF144A kidney,NS,carcinoma,renal cell c.410C>T p.A137V 6
5 COSM26987 RGS7 kidney,NS,carcinoma,renal cell c.169T>C p.F57L 6
6 COSM26614 RABGAP1 kidney,NS,carcinoma,renal cell c.1533T>A p.H511Q 6
7 COSM30530 PTPN22 kidney,NS,carcinoma,renal cell c.209G>C p.R70P 6
8 COSM27618 KMT2A kidney,NS,carcinoma,renal cell c.5711C>T p.A1904V 6
9 COSM30502 ITPR3 kidney,NS,carcinoma,renal cell c.4574G>T p.C1525F 6
10 COSM28415 DOCK1 kidney,NS,carcinoma,renal cell c.1306G>T p.D436Y 6
11 COSM30531 COPS4 kidney,NS,carcinoma,renal cell c.385G>C p.G129R 6
12 COSM25654 CDC5L kidney,NS,carcinoma,renal cell c.1196G>A p.R399Q 6
13 COSM30471 ARHGAP20 kidney,NS,carcinoma,renal cell c.1355A>G p.D452G 6
14 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 5
15 COSM17983 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.500G>A p.R167Q 5
16 COSM17957 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.292T>G p.Y98D 5
17 COSM14382 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 5
18 COSM14305 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 5
19 COSM17875 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.234T>G p.N78K 5
20 COSM14425 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-2A>T p.? 5
21 COSM52899 PBRM1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3805A>T p.K1269* 5

Expression for Childhood Kidney Cell Carcinoma

Search GEO for disease gene expression data for Childhood Kidney Cell Carcinoma.

Pathways for Childhood Kidney Cell Carcinoma

GO Terms for Childhood Kidney Cell Carcinoma

Cellular components related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 ASPSCR1 FOXO1 MITF MLH1 MSH2 PAX3

Biological processes related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 FOXO1 MITF PAX2 PAX3 TFE3 TFEB
2 positive regulation of transcription, DNA-templated GO:0045893 9.43 FOXO1 MITF PAX2 PAX3 TFE3 TFEB
3 somatic hypermutation of immunoglobulin genes GO:0016446 9.4 MLH1 MSH2
4 isotype switching GO:0045190 9.37 MLH1 MSH2
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 MLH1 MSH2
6 somatic recombination of immunoglobulin gene segments GO:0016447 9.26 MLH1 MSH2
7 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MLH1 MSH2
8 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Childhood Kidney Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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