MCID: CHL061
MIFTS: 49

Childhood Leukemia malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Childhood Leukemia

Aliases & Descriptions for Childhood Leukemia:

Name: Childhood Leukemia 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7757
NCIt 47 C4989
UMLS 69 C1332977

Summaries for Childhood Leukemia

MedlinePlus : 41 leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards based summary : Childhood Leukemia is related to hemophagocytic lymphohistiocytosis and acute lymphocytic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Childhood Leukemia is TCF3 (Transcription Factor 3), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Elliotts B Solution and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A leukemia that occurs in children.

Wikipedia : 71 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Related Diseases for Childhood Leukemia

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 29.2 ETV6 KMT2A PTPN11 RUNX1
2 acute lymphocytic leukemia 28.9 ETV6 KMT2A MLLT1 MLLT3 MTHFR RUNX1
3 leukemia 10.8
4 pediatric t-cell leukemia 10.8
5 med13l syndrome 10.7
6 rnase t2-deficient leukoencephalopathy 10.3 ETV6 KMT2A
7 comt-related pain sensitivity alteration 10.2 ETV6 RUNX1
8 plasmodium vivax malaria 10.2 PBX1 RUNX1
9 lymphomatoid granulomatosis 10.2 ETV6 KMT2A RUNX1
10 chondromyxoid fibroma 10.2 KMT2A MLLT3
11 adducted thumbs dundar type 10.2 ETV6 KMT2A RUNX1
12 tmem216-related meckel syndrome 10.2 HFE TFRC
13 lymphoma 10.1
14 nephrotic syndrome type 11 10.1 KMT2A MLLT1 MLLT3
15 lymphoblastic leukemia 10.1
16 phosphoserine phosphatase deficiency 10.1 ETV6 KMT2A RUNX1 TCF3
17 acute myocardial infarction 10.1 ETV6 MTHFR NQO1 RUNX1
18 adult acute lymphocytic leukemia 10.1 ETV6 MTHFR RUNX1
19 actinobacillosis 10.1 ETV6 PTPN11 RUNX1
20 hyperphosphatasia with mental retardation syndrome 2 10.1 ETV6 KMT2A PBX1 RUNX1 TCF3
21 warburg micro syndrome 3 10.1 MTHFR TFRC
22 milker's nodule 10.0 ETV6 KMT2A PTPN11 RUNX1
23 leukemia, acute myeloid 9.8 ETV6 KMT2A NQO1 PTPN11 RUNX1 TFRC
24 cranioectodermal dysplasia 1 9.8 ETV6 KMT2A MLLT1 MLLT3 PTPN11 RUNX1
25 liver disease 9.8 ETV6 MLLT1 MLLT3 MTHFR PBX1 PTPN11
26 hematopoietic stem cell transplantation 9.8
27 glucocorticoid resistance 9.7
28 arthritis 9.7
29 cerebritis 9.7
30 influenza 9.7
31 rheumatoid arthritis 9.6
32 hodgkin lymphoma 9.6
33 hemochromatosis 9.6
34 osteonecrosis 9.6
35 brain cancer 9.6
36 cytomegalic inclusion disease 9.6
37 back pain 9.6
38 amblyopia 9.5 ARID5B CYP1A1 ETV6 MLLT1 MTHFR PBX1
39 obesity 9.4
40 attention deficit-hyperactivity disorder 9.4
41 ataxia-telangiectasia 9.4
42 acute leukemia 9.4
43 hepatitis 9.4
44 severe combined immunodeficiency 9.4
45 thrombosis 9.4
46 osteomyelitis 9.4
47 gastric ulcer 9.4
48 pericardial effusion 9.4
49 testicular leukemia 9.4
50 down syndrome 9.4

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to Childhood Leukemia

Symptoms & Phenotypes for Childhood Leukemia

UMLS symptoms related to Childhood Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Childhood Leukemia:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 RUNX1 TCF3 TFRC ACTG1 ARID5B CYP1A1
2 homeostasis/metabolism MP:0005376 10.35 PTPN11 RUNX1 TCF3 TFRC CASP14 CYP1A1
3 hematopoietic system MP:0005397 10.34 NQO1 PBX1 PTPN11 RUNX1 TCF3 TFRC
4 immune system MP:0005387 10.27 ARID5B CYP1A1 ETV6 HFE KMT2A MLLT1
5 cellular MP:0005384 10.26 ARID5B ETV6 HFE KMT2A NQO1 PBX1
6 mortality/aging MP:0010768 10.2 ACTG1 ARID5B CYP1A1 EAF2 ETV6 HFE
7 integument MP:0010771 10.17 CASP14 EAF2 ETV6 KMT2A MTHFR NQO1
8 embryo MP:0005380 10.14 ETV6 KMT2A MLLT3 PBX1 PTPN11 RUNX1
9 endocrine/exocrine gland MP:0005379 10.13 ARID5B CYP1A1 EAF2 ETV6 PBX1 PTPN11
10 digestive/alimentary MP:0005381 10.09 ACTG1 ARID5B ETV6 HFE PBX1 PTPN11
11 liver/biliary system MP:0005370 10.07 CYP1A1 HFE KMT2A MLLT1 NQO1 PBX1
12 limbs/digits/tail MP:0005371 9.95 HFE KMT2A MTHFR PBX1 PTPN11 TCF3
13 neoplasm MP:0002006 9.91 MLLT1 MLLT3 NQO1 PTPN11 RUNX1 TCF3
14 no phenotypic analysis MP:0003012 9.85 CYP1A1 ETV6 HFE KMT2A MLLT3 MTHFR
15 normal MP:0002873 9.65 CYP1A1 ETV6 HFE KMT2A MLLT1 PBX1
16 reproductive system MP:0005389 9.23 TCF3 AKR1C3 ARID5B EAF2 KMT2A MTHFR

Drugs & Therapeutics for Childhood Leukemia

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Elliotts B Solution 17 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical Approved October 1996

Drugs for Childhood Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 429)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
4
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
5
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
6
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
7
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
10
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
12
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
13
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
14
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
16
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
17
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
20
Arsenic trioxide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1327-53-3 518740
21
Oprelvekin Approved, Investigational Phase 4 145941-26-0
22
Azathioprine Approved Phase 4 446-86-6 2265
23
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
24
Tretinoin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 302-79-4 5538
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
26
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
27
Ethylene Phase 4 74-85-1 6325
28 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
29 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1177-87-3
30 Imatinib Mesylate Phase 4,Phase 3,Phase 2,Phase 1 123596
31 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
32 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
34
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
37 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
38 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
42 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Hormones Phase 4,Phase 3,Phase 2,Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
46 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
49 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
50 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 759)
id Name Status NCT ID Phase
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4
2 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4
4 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
5 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4
6 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
7 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4
8 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
9 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4
10 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
11 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4
12 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4
13 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4
14 A Study for Improving the Outcome of Childhood Acute Promyeloid Leukemia Enrolling by invitation NCT02200978 Phase 4
15 Treating Patients With Childhood Acute Myeloid Leukemia With Interleukin-2 Unknown status NCT00149162 Phase 3
16 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3
17 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3
18 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3
19 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3
20 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3
21 Donor Stem Cell Transplant With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome Unknown status NCT00047268 Phase 3
22 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3
23 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3
24 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3
25 Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, Stage II, or Stage III Childhood Liver Cancer Unknown status NCT00652132 Phase 3
26 Imatinib Mesylate With or Without Interferon Alfa or Cytarabine Compared With Interferon Alfa Followed by Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia Unknown status NCT00055874 Phase 3
27 Treatment of Acute Lymphoblastic Leukemia in Children Unknown status NCT00400946 Phase 3
28 Chemotherapy, Interferon, and Bone Marrow Transplantation in Treating Patients With Chronic Myelogenous Leukemia Unknown status NCT00002771 Phase 3
29 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3
30 Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia Unknown status NCT00025402 Phase 3
31 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia Unknown status NCT00002926 Phase 3
32 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3
33 Quality of Life in Patients Who Have Undergone Previous Treatment for Primitive Neuroectodermal Tumors Unknown status NCT00278239 Phase 3
34 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3
35 Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma Unknown status NCT00379457 Phase 3
36 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3
37 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3
38 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3
39 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia Completed NCT00866918 Phase 3
40 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3
41 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3
42 Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia Completed NCT00015873 Phase 3
43 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3
44 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia Completed NCT00003436 Phase 3
45 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase Completed NCT00819351 Phase 3
46 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3
47 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3
48 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3
49 Treatment of Children and Adolescents With Refractory or Relapsed Acute Myeloid Leukemia Completed NCT00186966 Phase 3
50 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

MalaCards organs/tissues related to Childhood Leukemia:

39
Bone, Bone Marrow, Heart, Lymph Node, Brain, B Cells, Myeloid

Publications for Childhood Leukemia

Articles related to Childhood Leukemia:

(show top 50) (show all 629)
id Title Authors Year
1
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. ( 27783932 )
2017
2
Trends in childhood leukemia incidence over two decades from 1992 to 2013. ( 27778348 )
2017
3
Residential Proximity to Gasoline Stations and Risk of Childhood Leukemia. ( 27923798 )
2017
4
Immune Dysfunction After Completion of Childhood Leukemia Therapy. ( 27820131 )
2017
5
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia. ( 27726029 )
2017
6
Microstructure alterations in the Hypothalamus in cranially radiated Childhood Leukemia survivors but not in Craniopharyngioma patients unaffected by hypothalamic damage. ( 28502079 )
2017
7
Aberrant AML1 gene expression in the diagnosis of childhood leukemias not characterized by AML1-involved cytogenetic abnormalities. ( 28349830 )
2017
8
Impact of Ego-resilience and Family Function on Quality of Life in Childhood Leukemia Survivors. ( 28032062 )
2016
9
Residential mobility and the risk of childhood leukemia. ( 26830898 )
2016
10
A review of risk factors for childhood leukemia. ( 27735044 )
2016
11
Foreword: Childhood Leukemia and Primary Prevention. ( 27968953 )
2016
12
Genetic abnormalities associated with the relapse of childhood leukemia. ( 27498739 )
2016
13
Childhood leukemia and population mixing. ( 27804055 )
2016
14
Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study. ( 27318855 )
2016
15
A Phase I Study of Quizartinib Combined With Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. ( 26920889 )
2016
16
Home remodeling and risk of childhood leukemia. ( 28065451 )
2016
17
Childhood Leukemia: A Preventable Disease. ( 27940977 )
2016
18
Immunity in young adult survivors of childhood leukemia is more similar to elderly rather than age-matched controls: Role of cytomegalovirus (CMV). ( 27129782 )
2016
19
Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis. ( 26589707 )
2016
20
Background radiation and childhood leukemia: A nationwide register-based case-control study. ( 27405274 )
2016
21
Employment in French young adult survivors of childhood leukemia: an LEA study (for Leucemies de l'Enfant et de l'Adolescent-childhood and adolescent leukemia). ( 27185246 )
2016
22
Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. ( 26941364 )
2016
23
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. ( 26755588 )
2016
24
Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk. ( 27054704 )
2016
25
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia. ( 26708601 )
2016
26
Addressing behavioral impacts of childhood leukemia: A feasibility pilot randomized controlled trial of a group videoconferencing parenting intervention. ( 27697278 )
2016
27
Early childhood leukemia incidence trends in Brazil. ( 26925506 )
2016
28
A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California. ( 27494537 )
2016
29
Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium. ( 26991812 )
2016
30
Significant Association of Interleukin-10 Polymorphisms with Childhood Leukemia Susceptibility in Taiwan. ( 27107085 )
2016
31
Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). ( 27063976 )
2016
32
Acute childhood leukemia in India: Where are we going, where have we been? ( 27606303 )
2016
33
Breastfeeding, Other Early Life Exposures and Childhood Leukemia and Lymphoma. ( 27352124 )
2016
34
Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community. ( 27693118 )
2016
35
Matrix Metalloproteinase-1 Genotype Contributes to the Risk of Non-solid Tumor in Childhood Leukemia. ( 27798872 )
2016
36
Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia. ( 26951206 )
2016
37
Childhood Leukemia and Primary Prevention. ( 27968954 )
2016
38
A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study. ( 27271226 )
2016
39
Incidence and survival of childhood leukemia in Recife, Brazil: A population-based analysis. ( 28000427 )
2016
40
Associations between Metabolic Risk Factors and the Hypothalamic Volume in Childhood Leukemia Survivors Treated with Cranial Radiotherapy. ( 26824435 )
2016
41
Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. ( 27294727 )
2016
42
Preterm Birth and Subsequent Risk of Acute Childhood Leukemia: a Meta-Analysis of Observational Studies. ( 27595399 )
2016
43
Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study. ( 27858183 )
2016
44
Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group. ( 26914030 )
2016
45
Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium. ( 27492895 )
2016
46
Early Posttherapy Hospitalizations Among Survivors of Childhood Leukemia and Lymphoma. ( 26925709 )
2016
47
Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood. ( 27498291 )
2016
48
Childhood leukemia incidence in California: High and rising in the Hispanic population. ( 27351365 )
2016
49
Ophthalmic manifestations ofA relapsing acute childhood leukemia. ( 25890837 )
2015
50
Genes and childhood leukemia. ( 25748621 )
2015

Variations for Childhood Leukemia

Expression for Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for Childhood Leukemia

Pathways related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.75 NQO1 PBX1 RUNX1 TCF3
2 11.42 ETV6 KMT2A MLLT1 MLLT3 PBX1 RUNX1
3 10.54 AKR1C3 CYP1A1

GO Terms for Childhood Leukemia

Cellular components related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 HFE-transferrin receptor complex GO:1990712 8.96 HFE TFRC
2 transcription elongation factor complex GO:0008023 8.8 EAF2 MLLT1 MLLT3
3 nucleus GO:0005634 10 ACTG1 AKR1C3 ARID5B CASP14 EAF2 ETV6

Biological processes related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 EAF2 ETV6 KMT2A PBX1 RUNX1 TCF3
2 regulation of transcription, DNA-templated GO:0006355 9.85 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
3 transcription, DNA-templated GO:0006351 9.65 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
4 anterior/posterior pattern specification GO:0009952 9.54 KMT2A MLLT3 PBX1
5 transcription elongation from RNA polymerase II promoter GO:0006368 9.5 EAF2 MLLT1 MLLT3
6 embryonic hemopoiesis GO:0035162 9.4 KMT2A PBX1
7 hematopoietic stem cell proliferation GO:0071425 9.26 ETV6 RUNX1
8 transcription from RNA polymerase II promoter GO:0006366 9.17 EAF2 ETV6 KMT2A MLLT1 MLLT3 PBX1

Molecular functions related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ACTG1 ARID5B CASP14 CYP1A1 EAF2 ETV6
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.92 ARID5B EAF2 ETV6 RUNX1

Sources for Childhood Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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