MCID: CHL061
MIFTS: 38

Childhood Leukemia malady

Cancer diseases category
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Summaries for Childhood Leukemia

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards: Childhood Leukemia is related to leukemia and lymphoblastic leukemia. An important gene associated with Childhood Leukemia is TCF3 (transcription factor 3), and among its related pathways is Defensins. Affiliated tissues include bone, bone marrow and heart.

Disease Ontology:8 A leukemia that occurs in children.

Wikipedia:65 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Aliases & Classifications for Childhood Leukemia

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Sources:
8Disease Ontology, 34MedlinePlus, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

childhood leukemia 8 34 62


External Ids:

Disease Ontology8 DOID:7757
NCIt40 C4989

Related Diseases for Childhood Leukemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to childhood leukemia

Symptoms for Childhood Leukemia

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Drugs & Therapeutics for Childhood Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Childhood Leukemia

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

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Anatomical Context for Childhood Leukemia

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33MalaCards
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MalaCards organs/tissues related to Childhood Leukemia:

33
Bone, Bone marrow, Heart, Lymph node, Brain, B cells, Testes, T cells, Myeloid, Thyroid, Lung, Pituitary

Animal Models for Childhood Leukemia or affiliated genes

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Publications for Childhood Leukemia

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52PubMed
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Articles related to Childhood Leukemia:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Genetic predispositions to childhood leukemia. (23926459)
2013
2
Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. (23645686)
2013
3
Nutrition in early life and risk of childhood leukemia: a case-control study in Greece. (23179662)
2013
4
Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia. (24093751)
2013
5
Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. (22653976)
2012
6
Intellectual functioning of childhood leukemia survivors--relation to Tau protein--a marker of white matter injury. (23154429)
2012
7
In vitro fertilization and risk of childhood leukemia in Greece and Sweden. (21618418)
2012
8
Fulminant Clostridium perfringens sepsis during induction chemotherapy in childhood leukemia. (22631574)
2012
9
Back pain among long-term survivors of childhood leukemia. (23108003)
2012
10
Childhood leukemia--risk factors and the need for an interdisciplinary research agenda. (21958912)
2011
11
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
12
Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. (21618410)
2011
13
Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk. (21067287)
2010
14
Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia. (20617153)
2010
15
Constitutional mismatch repair deficiency and childhood leukemia/lymphoma--report on a novel biallelic MSH6 mutation. (20015892)
2010
16
Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium. (20582937)
2010
17
Genetic variation in the folate metabolic pathway and risk of childhood leukemia. (20101025)
2010
18
Questionable increase of childhood leukemia in Basrah, Iraq. (20705960)
2010
19
Re: "NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis". (19332427)
2009
20
Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia. (19590698)
2009
21
MRI of central nervous system abnormalities in childhood leukemia. (19517377)
2009
22
An evaluation of exposure metrics in an epidemiologic study on radio and television broadcast transmitters and the risk of childhood leukemia. (19025781)
2009
23
Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia. (17905612)
2008
24
Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage. (18575824)
2008
25
Case-control studies compare "apples and pears": Proposal for a retrospective cohort study in the USA of vaccination history in relation to subsequent childhood leukemia. (18774234)
2008
26
EMFs and childhood leukemia. (17687419)
2007
27
Exposure to magnetic fields and survival after diagnosis of childhood leukemia: a German cohort study. (17548680)
2007
28
Mutational analysis of the cell cycle inhibitor Kip1/p27 in childhood leukemia. (16526056)
2006
29
Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. (16620967)
2006
30
Molecular biomarkers for the study of childhood leukemia. (15967214)
2005
31
Aetiology of childhood leukemia. (16059922)
2005
32
Use of medication during pregnancy and risk of childhood leukemia (Canada). (15577295)
2004
33
Animal models for the study of childhood leukemia: considerations for model identification and optimization to identify potential risk factors. (15204718)
2004
34
Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukemia? (21432262)
2002
35
Low plasma levels of hemostatic proteins during the induction phase in children with acute lymphoblastic leukemia: A retrospective study by the JACLS. Japan Association of Childhood Leukemia Study. (11982900)
2002
36
Estimation of population attributable fractions from fitted incidence ratios and exposure survey data, with an application to electromagnetic fields and childhood leukemia. (11252596)
2001
37
A case-control pilot study of traffic exposures and early childhood leukemia using a geographic information system. (11170118)
2001
38
Do studies of wire code and childhood leukemia point towards or away from magnetic fields as the causal agent? (11170119)
2001
39
The potential impact of bias in studies of residential exposure to magnetic fields and childhood leukemia. (11170116)
2001
40
Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival. (11472578)
2001
41
Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein. (11001911)
2000
42
Childhood leukemia presenting with back pain and vertebral compression fractures. (10220099)
1999
43
Lineage switch in childhood leukemia with monosomy 7 and reverse of lineage switch in severe combined immunodeficient mice. (10340398)
1999
44
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group. (9718378)
1998
45
Facing the challenge of childhood leukemia. (9663133)
1998
46
Prevalence and natural history of hepatitis C infection in patients cured of childhood leukemia. (9373275)
1997
47
Childhood leukemia in Belarus before and after the Chernobyl accident. (8792453)
1996
48
Posttrauma symptoms in childhood leukemia survivors and their parents. (8849502)
1996
49
Is childhood leukemia the price of modernity? (7752249)
1995
50
CNS chemoradiotherapy of childhood leukemia: the plot thickens but the ending bodes well. (7595696)
1995

Variations for Childhood Leukemia

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Expression for genes affiliated with Childhood Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for genes affiliated with Childhood Leukemia

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50PathCards, 55Reactome
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Pathways related to Childhood Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.0DEFB127, DEFB118, DEFA4, DEFA6, DEFB126, DEFB119

Compounds for genes affiliated with Childhood Leukemia

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GO Terms for genes affiliated with Childhood Leukemia

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16Gene Ontology
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Cellular components related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.5DEFA4, DEFA6
2extracellular regionGO:0055767.1C8G, DEFB119, DEFB126, DEFA6, DEFA4, DEFB118

Biological processes related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to fungusGO:0508329.5DEFA4, DEFA6
2antibacterial humoral responseGO:0197319.4DEFA4, DEFA6
3killing of cells of other organismGO:0316409.2DEFA4, DEFA6
4defense response to bacteriumGO:0427429.1DEFB127, DEFB118, DEFB126, DEFB119
5innate immune responseGO:0450878.5DEFA6, DEFA4, DEFB118, DEFB127, C8G

Products for genes affiliated with Childhood Leukemia

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Sources for Childhood Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet