MCID: CHL061
MIFTS: 46

Childhood Leukemia malady

Summaries for Childhood Leukemia

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards: Childhood Leukemia is related to acute leukemia and acute lymphoblastic leukemia, childhood. An important gene associated with Childhood Leukemia is CDA (cytidine deaminase), and among its related pathways are Antimetabolite Pathway - Folate Cycle, Pharmacodynamics and Metabolism of vitamins and cofactors. The compounds methotrexate and tetrahydrofolate have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A leukemia that occurs in children.

Wikipedia:64 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Aliases & Classifications for Childhood Leukemia

Sources:
8Disease Ontology, 34MedlinePlus, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

childhood leukemia 8 34 61


External Ids:

Disease Ontology8 DOID:7757
NCIt40 C4989

Related Diseases for Childhood Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.0CDKN2B, DNTT, HFE, FPGS, CDA
2acute lymphoblastic leukemia, childhood30.8TYMS, SLC19A1, FPGS, CDKN2B, DNTT, HFE
3arthritis30.2HFE
4lymphoblastic lymphoma30.2DNTT, CDKN2B
5hemochromatosis30.1HFE, HAMP
6acute lymphocytic leukemia29.9CDA, HFE, TYMS, DNTT, CDKN2B, TCF3
7down syndrome29.8SLC19A1, MTRR
8t-cell leukemia10.4
9central nervous system leukemia10.2
10brain cancer10.2
11glucocorticoid resistance10.2
12hodgkin lymphoma, childhood10.1
13hematopoietic stem cell transplantation10.1
14neonatal leukemia10.1
15juvenile rheumatoid arthritis10.1
16cytomegalic inclusion disease10.1
17back pain10.1
18sepsis10.1
19leukemia10.0HFE, SLC19A1, FPGS, CDA, CDKN2B, DNTT
20breast cancer10.0TYMS, MTRR, FPGS, CASP14, SLC19A1, TPD52L2
21precursor t-cell acute lymphoblastic leukemia10.0DNTT, TYMS, SLC19A1, FPGS, CDKN2B
22non-small cell lung carcinoma10.0SLC19A1, TYMS, CDKN2B, CDA, FPGS
23neural tube defects10.0SLC19A1, TYMS, SHMT1, MTRR
24rheumatoid arthritis10.0HFE, DNTT, FPGS, SLC19A1
25hematologic cancer10.0CDA, CDKN2B, HFE, DNTT
26colorectal cancer10.0TYMS, SLC19A1, SHMT1, MTRR, FPGS
27folic acid deficiency anemia10.0SLC19A1, FPGS, TYMS
28leukemia, acute nonlymphocytic10.0FPGS, DNTT, TYMS
29adult acute lymphocytic leukemia10.0TYMS, CDKN2B, SHMT1
30hyperhomocysteinemia10.0MTRR, TYMS, SLC19A1
31deficiency anemia10.0TYMS, HFE, HAMP
32stomach cancer10.0SLC19A1, CDKN2B, TYMS
33burkitt's lymphoma10.0SLC19A1, TYMS, DNTT, SHMT1, CDKN2B
34myelodysplastic syndromes10.0HFE, DNTT, CDKN2B
35spina bifida10.0MTRR, SLC19A1
36colon cancer10.0SLC19A1, FPGS, CDKN2B, TYMS
37prostate cancer10.0HFE, CDKN2B, EAF2
38hemochromatosis type 210.0HFE, HAMP
39adenocarcinoma10.0TYMS
40ovarian cancer10.0TYMS, HFE
41hepatocellular carcinoma10.0CDKN2B, HFE
42lung cancer10.0TYMS
43sarcoma10.0FPGS
44myeloma10.0CDKN2B, DNTT
45retinoblastoma10.0TYMS, CDKN2B, TFPT
46adenoma10.0HFE
47psoriasis10.0CASP14
48attention deficit hyperactivity disorder9.9
49precursor b lymphoblastic lymphoma/leukemia9.9
50hepatitis c9.9

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to childhood leukemia

Clinical Features for Childhood Leukemia

Drugs & Therapeutics for Childhood Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Childhood Leukemia

Drug clinical trials:

Search ClinicalTrials for Childhood Leukemia

Search NIH Clinical Center for Childhood Leukemia

Search CenterWatch for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

Animal Models for Childhood Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Childhood Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.2HAMP, HFE, CBX8, DNTT, CDKN2B, SLC19A1
2MP:000537611.1CASP14, HAMP, MTRR, SHMT1, HFE, CDKN2B

Publications for Childhood Leukemia

Sources:
51PubMed
See all sources

Articles related to Childhood Leukemia:

(show top 50)    (show all 1362)
idTitleAuthorsYear
1
Using a bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. (24367687)
2013
2
HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia. (23472968)
2013
3
Lineage classification of childhood acute lymphoblastic leukemia according to the EGIL recommendations: results of the ALL-BFM 2000 trial. (23700065)
2013
4
WT1 microdeletion and slowly progressing focal glomerulosclerosis in a patient with male pseudohermaphroditism, childhood leukemia, Wilms tumor and cerebellar angioblastoma. (23618379)
2013
5
Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study. (24038890)
2013
6
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. (24141364)
2013
7
Environmental radon exposure and childhood leukemia. (22852813)
2012
8
Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. (22589484)
2012
9
Lineage switch in childhood acute leukemia: an unusual event with poor outcome. (22685031)
2012
10
Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (21606961)
2011
11
Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia. (21784522)
2011
12
An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. (21270240)
2011
13
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia. (21987080)
2011
14
Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL). (20510681)
2010
15
Heart transplant in a childhood leukemia survivor: a case report. (20199376)
2010
16
Childhood leukemia. (20516235)
2010
17
Alternaria sinusitis in children with acute myeloid leukemia: case reports from the Childhood Acute Myeloid Leukemia Infection Research Group. (20001237)
2010
18
Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. (21098271)
2010
19
Polymorphisms in innate immunity genes and risk of childhood leukemia. (20438785)
2010
20
Genome-wide association study of childhood acute lymphoblastic leukemia in Korea. (20189245)
2010
21
Good early treatment response in childhood acute lymphoblastic leukemia is associated with Bax nuclear accumulation and PARP cleavage. (19478700)
2009
22
JAK mutations in high-risk childhood acute lymphoblastic leukemia. (19470474)
2009
23
Scholastic achievements of childhood leukemia patients: a nationwide, register-based study. (17687156)
2007
24
Are elevated serum levels of IGFBP-2 after intensive chemotherapy of childhood acute lymphoblastic leukemia a risk factor of relapse? (18217408)
2007
25
Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (15201966)
2004
26
Animal models for the study of childhood leukemia: considerations for model identification and optimization to identify potential risk factors. (15204718)
2004
27
Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. (15114597)
2004
28
The expression of CD19 in 210 cases of childhood acute leukemia and its significance]. (15144712)
2004
29
Breastfeeding and the risk of childhood leukemia: a meta-analysis. (15504444)
2004
30
RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia. (14990973)
2004
31
Increasing incidence of childhood leukemia in Northwest Italy, 1975-98. (12712449)
2003
32
Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the disease. (12883040)
2003
33
Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukemia? (21432262)
2002
34
In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia. (12010814)
2002
35
Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). (11899114)
2002
36
Facial palsy, an unusual presenting feature of childhood leukemia. (12160979)
2002
37
Immune escape mechanisms of childhood ALL and a potential countering role for DC-like leukemia cells. (12006212)
2002
38
In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37 degrees C, but not with affinity determined at room temperature. (12200716)
2002
39
MDM2 and p53 in childhood acute lymphoblastic leukemia: higher expression in childhood leukemias with poor prognosis compared to long-term survivors. (11764099)
2001
40
Fine characterization of childhood and adult acute lymphoblastic leukemia (ALL) by a proB and preB surrogate light chain-specific mAb and a proposal for a new B cell ALL classification. (11187899)
2000
41
Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada. (10454069)
1999
42
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group. (9718378)
1998
43
Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. (9399648)
1997
44
Childhood leukemia and electromagnetic fields: results of a population-based case-control study in Germany. (9134240)
1997
45
Adult and childhood acute lymphoblastic leukemia: clinico-biological differences based on CD34 antigen expression. (9107079)
1997
46
Posttrauma symptoms in childhood leukemia survivors and their parents. (8849502)
1996
47
In vitro chemosensitivity assessed with the MTT assay in childhood acute non-lymphoblastic leukemia. (7475276)
1995
48
Trends and geographical distribution of childhood leukemia in Greece in relation to the Chernobyl accident. (8091154)
1994
49
Heterogeneity of acute "undifferentiated" leukemia of childhood: ultrastructural, immunophenotypic, and karyotypic analyses. (2309978)
1990
50
Electron microscopic studies on leukemic cells in suspension culture in childhood acute monocytic leukemia. (284701)
1979

Genetic Variations for Childhood Leukemia

Expression for genes affiliated with Childhood Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for genes affiliated with Childhood Leukemia

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Childhood Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Childhood Leukemia according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1methotrexate45 50 1113.5MTRR, SHMT1, TYMS, DNTT, CDKN2B, FPGS
2tetrahydrofolate4511.4SLC19A1, FPGS, TYMS, SHMT1, MTRR
3dihydrofolate4511.4SLC19A1, FPGS, CDKN2B, TYMS, SHMT1
4purine45 2412.4SHMT1, TYMS, DNTT, FPGS, SLC19A1
5thymidylate4511.4MTRR, SHMT1, TYMS, FPGS, SLC19A1
6folate4511.3MTRR, SHMT1, TYMS, FPGS, SLC19A1
7cisplatin45 50 60 1114.3CASP14, TYMS, DNTT, CDA, SLC19A1
8aspartate4511.3CASP14, TFPT, MTRR, HFE, DNTT
9cytarabine45 50 1113.2TYMS, CDKN2B, CDA, FPGS
10ag 20344511.2TYMS, FPGS, SLC19A1
11edatrexate4511.2TYMS, FPGS, SLC19A1
12lometrexol4511.2TYMS, FPGS, SLC19A1
131843u894511.2TYMS, FPGS, SLC19A1
14b vitamins4511.2MTRR, SHMT1, TYMS
15aminopterin45 1112.2TYMS, FPGS, SLC19A1
16trimetrexate45 1112.2TYMS, FPGS, SLC19A1
17zd93314511.2TYMS, FPGS, SLC19A1
18tomudex4511.2SLC19A1, FPGS, TYMS
19aicar45 11 2413.1SLC19A1, FPGS, TYMS
20methionine4511.1SLC19A1, FPGS, SHMT1, MTRR
21leucovorin45 50 1113.1TYMS, FPGS, SLC19A1
22probenecid45 29 60 50 1115.1SLC19A1, DNTT, TYMS
23pyrimidine45 2412.1FPGS, CDA, TYMS
24Pralatrexate1111.1TYMS, FPGS
25raltitrexed50 1112.1TYMS, FPGS
26metoprine4511.1TYMS, SLC19A1
27ag 3314511.0TYMS, SLC19A1
28pt5234511.0SLC19A1, TYMS
29ag 3374511.0SLC19A1, TYMS
30serine4511.0CDKN2B, TFPT
31hdmtx4511.0SLC19A1, FPGS
32glycinamide ribonucleotide45 1112.0TYMS, FPGS
33gemcitabine45 50 1113.0FPGS, CDA, TYMS
34thiophene4511.0FPGS, TYMS
35deoxyribonucleotide4511.0DNTT, SHMT1
36quinazoline4511.0FPGS, SLC19A1
37p0034511.0CDKN2B, HFE, MTRR
38ara-ctp4511.0CDA, TYMS
395-methyltetrahydrofolate45 1111.9MTRR, SLC19A1
40pteridine4510.9FPGS, SLC19A1
41dttp4510.9TYMS, DNTT
42dcmp45 2411.9TYMS, CDA
43homocysteine45 2411.9SLC19A1, SHMT1, MTRR
44dichloromethane4510.8CDA, TYMS
45Tetrahydrofolic acid11 2411.8FPGS, SHMT1
46s-adenosylmethionine45 11 2412.7SLC19A1, SHMT1, MTRR
47capecitabine45 50 1112.7TYMS, CDA
48deoxyuridine45 2411.7CDA, TYMS
49triphosphate45 2411.6TYMS, DNTT
505-methylthioadenosine4510.4CDKN2B, TYMS

GO Terms for genes affiliated with Childhood Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.4TFPT, MTRR, SHMT1, TYMS, DNTT, CDKN2B
2ELL-EAF complexGO:03278310.4EAF1, EAF2

Biological processes related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid metabolic processGO:04665510.7SLC19A1, FPGS, SHMT1
2water-soluble vitamin metabolic processGO:00676710.7MTRR, SHMT1, FPGS, SLC19A1
3pyrimidine nucleobase metabolic processGO:00620610.7CDA, TYMS
4vitamin metabolic processGO:00676610.5SLC19A1, FPGS, SHMT1, MTRR

Molecular functions related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00554210.7SLC19A1, TYMS
2protein homodimerization activityGO:04280310.6TPD52L2, TCF3, CDA, TYMS, SHMT1

Products for genes affiliated with Childhood Leukemia

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  • Antibodies

Sources for Childhood Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet