MCID: CHL061
MIFTS: 52

Childhood Leukemia malady

Summaries for Childhood Leukemia

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards: Childhood Leukemia is related to leukemia and acute leukemia. An important gene associated with Childhood Leukemia is CDA (cytidine deaminase), and among its related pathways are Antimetabolite Pathway - Folate Cycle, Pharmacodynamics and Metabolism of vitamins and cofactors. The compounds methotrexate and tetrahydrofolate have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and b cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A leukemia that occurs in children.

Wikipedia:63 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Aliases & Classifications for Childhood Leukemia

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8Disease Ontology, 33MedlinePlus, 60UMLS, 39NCIt
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Aliases & Descriptions:

childhood leukemia 8 33 60


External Ids:

Disease Ontology8 DOID:7757
NCIt39 C4989

Related Diseases for Childhood Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9TCF3, TFPT, HFE, TYMS, DNTT, CDKN2B
2acute leukemia31.0HFE, DNTT, CDKN2B, CDA, FPGS
3arthritis30.2HFE
4rheumatoid arthritis30.1HFE, DNTT, FPGS, SLC19A1
5hemochromatosis30.0HAMP, HFE
6acute lymphocytic leukemia29.8HFE, TYMS, DNTT, CDKN2B, CDA, FPGS
7lymphoblastic leukemia10.5
8central nervous system leukemia10.2
9brain cancer10.1
10influenza10.1
11non-hodgkin lymphoma10.0
12cerebritis10.0
13neonatal leukemia10.0
14juvenile rheumatoid arthritis10.0
15meningioma10.0
16acute lymphoblastic leukemia, childhood10.0HFE, TYMS, DNTT, CDKN2B, FPGS, SLC19A1
17breast cancer10.0CASP14, MTRR, SHMT1, TYMS, FPGS, SLC19A1
18precursor t-cell acute lymphoblastic leukemia10.0TYMS, DNTT, CDKN2B, FPGS, SLC19A1
19non-small cell lung carcinoma10.0TYMS, CDKN2B, CDA, FPGS, SLC19A1
20neural tube defects10.0SLC19A1, TYMS, SHMT1, MTRR
21hematologic cancer10.0CDA, CDKN2B, DNTT, HFE
22colorectal cancer10.0MTRR, SHMT1, TYMS, FPGS, SLC19A1
23folic acid deficiency anemia10.0SLC19A1, FPGS, TYMS
24leukemia, acute nonlymphocytic10.0FPGS, DNTT, TYMS
25adult acute lymphocytic leukemia10.0SHMT1, TYMS, CDKN2B
26hyperhomocysteinemia10.0SLC19A1, TYMS, MTRR
27deficiency anemia10.0HAMP, HFE, TYMS
28stomach cancer10.0SLC19A1, CDKN2B, TYMS
29burkitt's lymphoma10.0SHMT1, TYMS, DNTT, CDKN2B, SLC19A1
30myelodysplastic syndromes10.0CDKN2B, DNTT, HFE
31spina bifida10.0SLC19A1, MTRR
32colon cancer10.0TYMS, CDKN2B, FPGS, SLC19A1
33prostate cancer10.0EAF2, CDKN2B, HFE
34hemochromatosis type 210.0HAMP, HFE
35adenocarcinoma10.0TYMS
36ovarian cancer10.0TYMS, HFE
37down syndrome10.0MTRR, SLC19A1
38hepatocellular carcinoma10.0CDKN2B, HFE
39lung cancer10.0TYMS
40sarcoma10.0FPGS
41myeloma10.0DNTT, CDKN2B
42retinoblastoma10.0TFPT, TYMS, CDKN2B
43adenoma10.0HFE
44lymphoblastic lymphoma10.0CDKN2B, DNTT
45psoriasis10.0CASP14
46attention deficit hyperactivity disorder9.9
47acute thyroiditis9.9
48hepatitis c9.9
49hemophagocytic lymphohistiocytosis9.9
50osteonecrosis9.9

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to childhood leukemia

Clinical Features for Childhood Leukemia

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Drugs & Therapeutics for Childhood Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood Leukemia

Drug clinical trials:

Search ClinicalTrials for Childhood Leukemia

Search NIH Clinical Center for Childhood Leukemia

Search CenterWatch for Childhood Leukemia

Genetic Tests for Childhood Leukemia

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Anatomical Context for Childhood Leukemia

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32MalaCards
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MalaCards organs/tissues related to Childhood Leukemia:

32
Myeloid, Bone, B cells, Bone marrow, T cells, Heart, Lymph node, Monocytes, Lung, Brain, Endothelial, Testes, Liver, Breast, Thyroid, Spleen, Tongue, Pituitary

Animal Models for Childhood Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Childhood Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.2HFE, CBX8, DNTT, CDKN2B, SLC19A1, TCF3
2MP:000537611.1LAT2, CASP14, HAMP, MTRR, SHMT1, HFE

Publications for Childhood Leukemia

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50PubMed
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Articles related to Childhood Leukemia:

(show top 50)    (show all 1360)
idTitleAuthorsYear
1
Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. (24045615)
2014
2
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells. (24052107)
2014
3
Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. (23645686)
2013
4
GSTM1 and GSTT1 null polymorphisms and childhood acute leukemia risk: evidence from 26 case-control studies. (24194954)
2013
5
Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. (22653976)
2012
6
Lack of association between MTHFR C677T and A1298C polymorphisms and risk of childhood acute lymphoblastic leukemia in the Kurdish population from Western Iran. (22017305)
2012
7
Intrauterine growth and childhood leukemia and lymphoma risk. (23146059)
2012
8
Multidrug resistance-associated protein 1 predicts relapse in Iranian childhood acute lymphoblastic leukemia. (22901208)
2012
9
Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases. (23049407)
2012
10
Magnetic resonance imaging in childhood leukemia survivors treated with cranial radiotherapy: a cross sectional, single center study. (21671360)
2011
11
Prognostic impact of t(1;19)/ TCF3-PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin-Frankfurt-MA1nster-based protocols. (21534874)
2011
12
TET2 mutations in childhood leukemia. (21042320)
2011
13
Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. (20944149)
2010
14
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. (19953649)
2010
15
Fms-like tyrosine kinase 3 mutations in childhood acute leukemias and their association with prognosis. (21133602)
2010
16
Radiation-induced meningiomas: a shadow in the success story of childhood leukemia. (19179425)
2009
17
Surviving childhood leukemia: career, family, and future expectations. (18174532)
2008
18
Tumor associated antigen PRAME is a marker of favorable prognosis in childhood acute myeloid leukemia patients and modifies the expression of S100A4, Hsp 27, p21, IL-8 and IGFBP-2 in vitro and in vivo. (18452107)
2008
19
Expression of cyclin A in childhood acute leukemia and its significance]. (19176011)
2008
20
Transformation of childhood MDS-refractory anemia to acute lymphoblastic leukemia. (17921857)
2007
21
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. (17255265)
2007
22
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. (17071479)
2006
23
Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. (16894525)
2006
24
Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. (16548914)
2006
25
Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases. (16552772)
2006
26
Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. (16182364)
2006
27
Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures. (17049456)
2006
28
Study on clinical and biological characteristics of childhood acute leukemia with MLL gene rearrangements]. (16383239)
2005
29
Molecular biomarkers for the study of childhood leukemia. (15967214)
2005
30
Proteomic analysis of childhood leukemia. (16136170)
2005
31
Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. (16028218)
2005
32
Genes predict childhood leukemia outcome. (15970261)
2005
33
Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. (15356655)
2004
34
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia. (14770434)
2004
35
Childhood leukemia, military aviation facilities, and population mixing. (15471717)
2004
36
Childhood leukemia: electric and magnetic fields as possible risk factors. (12782499)
2003
37
The potential impact of bias in studies of residential exposure to magnetic fields and childhood leukemia. (11170116)
2001
38
Reversible erythrocyte skeleton destabilization is modulated by beta-spectrin phosphorylation in childhood leukemia. (11237068)
2001
39
Evidence on the infectious etiology of childhood leukemia: the role of low herd immunity (Greece). (11552712)
2001
40
Maternal pesticide exposure and childhood leukemia. (11021627)
2000
41
Neonatal level of thyroid-stimulating hormone and acute childhood leukemia. (11054681)
2000
42
Genetic susceptibility to childhood acute lymphoblastic leukemia. (10953966)
2000
43
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. (10995007)
2000
44
Analysis of cyclin D1 in de novo and relapsed childhood acute lymphoblastic leukemia. (10216470)
1999
45
The relationship between the expression of transferrin receptors (TfR) on leukemia cells and the cell proliferation and iron metabolism status in childhood acute leukemias]. (11601239)
1999
46
Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. (8637234)
1996
47
Is childhood leukemia the price of modernity? (7752249)
1995
48
Expression of myeloperoxidase mRNA by leukemic cells from childhood acute lymphoblastic leukemia. (8394481)
1993
49
A comparison of two regimens for high-risk acute lymphocytic leukemia in childhood. A Pediatric Oncology Group Study. (2910421)
1989
50
Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study. (2778483)
1989

Genetic Variations for Childhood Leukemia

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Expression for genes affiliated with Childhood Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for genes affiliated with Childhood Leukemia

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49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Childhood Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Childhood Leukemia according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1methotrexate44 49 1113.5MTRR, SHMT1, TYMS, DNTT, CDKN2B, FPGS
2tetrahydrofolate4411.4SLC19A1, FPGS, TYMS, SHMT1, MTRR
3dihydrofolate4411.4SLC19A1, FPGS, CDKN2B, TYMS, SHMT1
4purine44 2412.4SHMT1, TYMS, DNTT, FPGS, SLC19A1
5thymidylate4411.4MTRR, SHMT1, TYMS, FPGS, SLC19A1
6folate4411.3MTRR, SHMT1, TYMS, FPGS, SLC19A1
7cisplatin44 49 59 1114.3CASP14, TYMS, DNTT, CDA, SLC19A1
8aspartate4411.3CASP14, TFPT, MTRR, HFE, DNTT
9cytarabine44 49 1113.2TYMS, CDKN2B, CDA, FPGS
10ag 20344411.2TYMS, FPGS, SLC19A1
11edatrexate4411.2TYMS, FPGS, SLC19A1
12lometrexol4411.2TYMS, FPGS, SLC19A1
131843u894411.2TYMS, FPGS, SLC19A1
14b vitamins4411.2MTRR, SHMT1, TYMS
15aminopterin44 1112.2TYMS, FPGS, SLC19A1
16trimetrexate44 1112.2TYMS, FPGS, SLC19A1
17zd93314411.2TYMS, FPGS, SLC19A1
18tomudex4411.2SLC19A1, FPGS, TYMS
19aicar44 11 2413.1SLC19A1, FPGS, TYMS
20methionine4411.1SLC19A1, FPGS, SHMT1, MTRR
21leucovorin44 49 1113.1TYMS, FPGS, SLC19A1
22probenecid44 28 59 49 1115.1SLC19A1, DNTT, TYMS
23pyrimidine44 2412.1FPGS, CDA, TYMS
24Pralatrexate1111.1TYMS, FPGS
25raltitrexed49 1112.1TYMS, FPGS
26metoprine4411.1TYMS, SLC19A1
27ag 3314411.0TYMS, SLC19A1
28pt5234411.0SLC19A1, TYMS
29ag 3374411.0SLC19A1, TYMS
30serine4411.0CDKN2B, TFPT
31hdmtx4411.0SLC19A1, FPGS
32glycinamide ribonucleotide44 1112.0TYMS, FPGS
33gemcitabine44 49 1113.0FPGS, CDA, TYMS
34thiophene4411.0FPGS, TYMS
35deoxyribonucleotide4411.0DNTT, SHMT1
36quinazoline4411.0FPGS, SLC19A1
37p0034411.0CDKN2B, HFE, MTRR
38ara-ctp4411.0CDA, TYMS
395-methyltetrahydrofolate44 1111.9MTRR, SLC19A1
40pteridine4410.9FPGS, SLC19A1
41dttp4410.9TYMS, DNTT
42dcmp44 2411.9TYMS, CDA
43homocysteine44 2411.9SLC19A1, SHMT1, MTRR
44dichloromethane4410.8CDA, TYMS
45Tetrahydrofolic acid11 2411.8FPGS, SHMT1
46s-adenosylmethionine44 11 2412.7SLC19A1, SHMT1, MTRR
47capecitabine44 49 1112.7TYMS, CDA
48deoxyuridine44 2411.7CDA, TYMS
49triphosphate44 2411.6TYMS, DNTT
505-methylthioadenosine4410.4CDKN2B, TYMS

GO Terms for genes affiliated with Childhood Leukemia

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16Gene Ontology
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Cellular components related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.4CASP14, TFPT, MTRR, SHMT1, TYMS, DNTT
2ELL-EAF complexGO:03278310.4EAF2, EAF1

Biological processes related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid metabolic processGO:04665510.7SLC19A1, FPGS, SHMT1
2water-soluble vitamin metabolic processGO:00676710.7MTRR, SHMT1, FPGS, SLC19A1
3pyrimidine nucleobase metabolic processGO:00620610.7CDA, TYMS
4vitamin metabolic processGO:00676610.5SLC19A1, FPGS, SHMT1, MTRR

Molecular functions related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00554210.7SLC19A1, TYMS
2protein homodimerization activityGO:04280310.6TPD52L2, TCF3, CDA, TYMS, SHMT1

Products for genes affiliated with Childhood Leukemia

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Sources for Childhood Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet