MCID: CHL061
MIFTS: 52

Childhood Leukemia malady

Summaries for Childhood Leukemia

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards: Childhood Leukemia is related to leukemia and acute leukemia. An important gene associated with Childhood Leukemia is CDA (cytidine deaminase), and among its related pathways are Antimetabolite Pathway - Folate Cycle, Pharmacodynamics and Metabolism of vitamins and cofactors. The compounds methotrexate and tetrahydrofolate have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and b cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A leukemia that occurs in children.

Wikipedia:63 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Aliases & Classifications for Childhood Leukemia

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8Disease Ontology, 33MedlinePlus, 60UMLS, 39NCIt
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Aliases & Descriptions:

childhood leukemia 8 33 60


External Ids:

Disease Ontology8 DOID:7757
NCIt39 C4989

Related Diseases for Childhood Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9TCF3, TFPT, HFE, TYMS, DNTT, CDKN2B
2acute leukemia31.0HFE, DNTT, CDKN2B, CDA, FPGS
3arthritis30.2HFE
4rheumatoid arthritis30.1HFE, DNTT, FPGS, SLC19A1
5hemochromatosis30.0HAMP, HFE
6acute lymphocytic leukemia29.8HFE, TYMS, DNTT, CDKN2B, CDA, FPGS
7lymphoblastic leukemia10.5
8central nervous system leukemia10.2
9brain cancer10.1
10influenza10.1
11non-hodgkin lymphoma10.0
12cerebritis10.0
13neonatal leukemia10.0
14juvenile rheumatoid arthritis10.0
15meningioma10.0
16acute lymphoblastic leukemia, childhood10.0HFE, TYMS, DNTT, CDKN2B, FPGS, SLC19A1
17breast cancer10.0CASP14, MTRR, SHMT1, TYMS, FPGS, SLC19A1
18precursor t-cell acute lymphoblastic leukemia10.0TYMS, DNTT, CDKN2B, FPGS, SLC19A1
19non-small cell lung carcinoma10.0TYMS, CDKN2B, CDA, FPGS, SLC19A1
20neural tube defects10.0SLC19A1, TYMS, SHMT1, MTRR
21hematologic cancer10.0CDA, CDKN2B, DNTT, HFE
22colorectal cancer10.0MTRR, SHMT1, TYMS, FPGS, SLC19A1
23folic acid deficiency anemia10.0SLC19A1, FPGS, TYMS
24leukemia, acute nonlymphocytic10.0FPGS, DNTT, TYMS
25adult acute lymphocytic leukemia10.0SHMT1, TYMS, CDKN2B
26hyperhomocysteinemia10.0SLC19A1, TYMS, MTRR
27deficiency anemia10.0HAMP, HFE, TYMS
28stomach cancer10.0SLC19A1, CDKN2B, TYMS
29burkitt's lymphoma10.0SHMT1, TYMS, DNTT, CDKN2B, SLC19A1
30myelodysplastic syndromes10.0CDKN2B, DNTT, HFE
31spina bifida10.0SLC19A1, MTRR
32colon cancer10.0TYMS, CDKN2B, FPGS, SLC19A1
33prostate cancer10.0EAF2, CDKN2B, HFE
34hemochromatosis type 210.0HAMP, HFE
35adenocarcinoma10.0TYMS
36ovarian cancer10.0TYMS, HFE
37down syndrome10.0MTRR, SLC19A1
38hepatocellular carcinoma10.0CDKN2B, HFE
39lung cancer10.0TYMS
40sarcoma10.0FPGS
41myeloma10.0DNTT, CDKN2B
42retinoblastoma10.0TFPT, TYMS, CDKN2B
43adenoma10.0HFE
44lymphoblastic lymphoma10.0CDKN2B, DNTT
45psoriasis10.0CASP14
46attention deficit hyperactivity disorder9.9
47acute thyroiditis9.9
48hepatitis c9.9
49hemophagocytic lymphohistiocytosis9.9
50osteonecrosis9.9

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to childhood leukemia

Clinical Features for Childhood Leukemia

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Drugs & Therapeutics for Childhood Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood Leukemia

Drug clinical trials:

Search ClinicalTrials for Childhood Leukemia

Search NIH Clinical Center for Childhood Leukemia

Search CenterWatch for Childhood Leukemia

Genetic Tests for Childhood Leukemia

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Anatomical Context for Childhood Leukemia

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32MalaCards
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MalaCards organs/tissues related to Childhood Leukemia:

32
Myeloid, Bone, B cells, Bone marrow, T cells, Heart, Lymph node, Monocytes, Lung, Brain, Endothelial, Liver, Testes, Tongue, Breast, Thyroid, Spleen, Pituitary

Animal Models for Childhood Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Childhood Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.2HFE, CBX8, DNTT, CDKN2B, SLC19A1, TCF3
2MP:000537611.1LAT2, CASP14, HAMP, MTRR, SHMT1, HFE

Publications for Childhood Leukemia

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50PubMed
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Articles related to Childhood Leukemia:

(show top 50)    (show all 1360)
idTitleAuthorsYear
1
Minimal residual disease-based risk stratification in chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction. (23936021)
2013
2
Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms. (23404349)
2013
3
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. (23996088)
2013
4
DNA repair gene XRCC1 polymorphisms and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis. (23997527)
2013
5
Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a metaanalysis. (24060443)
2013
6
Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium. (23754574)
2013
7
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. (23007406)
2012
8
Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil. (21888617)
2012
9
Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia. (21254377)
2012
10
Higher urinary excretion of inorganic phosphate during early induction chemotherapy predicts a good prognosis in childhood acute leukemia. (21423043)
2011
11
Pharmacogenomics of cytarabine in childhood leukemia. (22118048)
2011
12
Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia. (20617153)
2010
13
Treating childhood leukemia without cranial irradiation. (19780213)
2009
14
Transient hyperglycemia during childhood acute lymphocytic leukemia chemotherapy: an old event revisited. (19701154)
2009
15
P-glycoprotein activity predicts outcome in childhood acute lymphoblastic leukemia. (19564743)
2009
16
Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage. (18575824)
2008
17
Detection of human cyclin C gene expression in childhood acute lymphocytic leukemia using real-time fluorescence quantitative PCR]. (18289462)
2008
18
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. (18202291)
2008
19
CpG island methylator phenotype and childhood leukemia. (16914562)
2006
20
Childhood leukemia--new advances and challenges. (15295054)
2004
21
Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. (14991750)
2004
22
Preliminary results of evaluation of progress in chemotherapy for childhood leukemia patients employing Fourier-transform infrared microspectroscopy and cluster analysis. (12819636)
2003
23
Correspondence re: R. Varon et al., Mutations in the Nijmegen breakage syndrome gene (NBS1) in childhood acute lymphoblastic leukemia. Cancer Res., 61: 3570-3572, 2001. (14559852)
2003
24
Identification of gene expression profiles that segregate patients with childhood leukemia. (12374679)
2002
25
AML1 amplification in a case of childhood acute lymphoblastic leukemia. (12393286)
2002
26
Contact voltage measured in residences: implications to the association between magnetic fields and childhood leukemia. (12210565)
2002
27
Critical windows of exposure to household pesticides and risk of childhood leukemia. (12204832)
2002
28
Estimation of population attributable fractions from fitted incidence ratios and exposure survey data, with an application to electromagnetic fields and childhood leukemia. (11252596)
2001
29
Do studies of wire code and childhood leukemia point towards or away from magnetic fields as the causal agent? (11170119)
2001
30
Olfactory neuroblastoma as a second malignant neoplasm in a patient previously treated for childhood acute leukemia. (11594709)
2001
31
Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. (11468150)
2001
32
Autologous bone marrow transplantation for childhood acute lymphoblastic leukemia: a novel combined approach consisting of ex vivo marrow purging, modulation of multi-drug resistance, induction of autograft vs leukemia effect, and post-transplant immuno- and chemotherapy (PTIC). (11281383)
2001
33
Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction. (11705851)
2001
34
Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein. (11001911)
2000
35
Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia. (10891465)
2000
36
Childhood leukemia presenting with back pain and vertebral compression fractures. (10220099)
1999
37
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia. (10071127)
1999
38
Residential magnetic fields and childhood leukemia: a meta-analysis. (9842375)
1998
39
Prognostic implications of cyclins (D1, E, A), cyclin-dependent kinases (CDK2, CDK4) and tumor-suppressor genes (pRB, p16INK4A) in childhood acute lymphoblastic leukemia. (9355972)
1997
40
Residual clones in childhood leukemia. (9213774)
1997
41
The need for exposure grouping strategies in studies of magnetic fields and childhood leukemia. (9229220)
1997
42
Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood. (9053478)
1997
43
Expression of lung resistance-related protein (LRP) in initial and relapsed childhood acute lymphoblastic leukemia. (9311441)
1997
44
Demodicidosis in childhood acute lymphoblastic leukemia; an opportunistic infection occurring with immunosuppression. (7472831)
1995
45
Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow transplantation with ex vivo purging and systemic IL-2 infusion: unsuccessful prediction of subsequent relapse. (8535317)
1995
46
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. (7812005)
1995
47
Aetiology of childhood leukemia. (8048837)
1994
48
Effect of high-dose methotrexate on plasma hypoxanthine and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma in childhood. (1434805)
1992
49
Childhood undifferentiated leukemia with early erythroid markers and c-myb duplication. (1708434)
1991
50
Central nervous system leukemia and solid tumors of childhood. Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). (4288265)
1966

Genetic Variations for Childhood Leukemia

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Expression for genes affiliated with Childhood Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for genes affiliated with Childhood Leukemia

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49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Childhood Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Childhood Leukemia according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1methotrexate44 49 1113.5MTRR, SHMT1, TYMS, DNTT, CDKN2B, FPGS
2tetrahydrofolate4411.4SLC19A1, FPGS, TYMS, SHMT1, MTRR
3dihydrofolate4411.4SLC19A1, FPGS, CDKN2B, TYMS, SHMT1
4purine44 2412.4SHMT1, TYMS, DNTT, FPGS, SLC19A1
5thymidylate4411.4MTRR, SHMT1, TYMS, FPGS, SLC19A1
6folate4411.3MTRR, SHMT1, TYMS, FPGS, SLC19A1
7cisplatin44 49 59 1114.3CASP14, TYMS, DNTT, CDA, SLC19A1
8aspartate4411.3CASP14, TFPT, MTRR, HFE, DNTT
9cytarabine44 49 1113.2TYMS, CDKN2B, CDA, FPGS
10ag 20344411.2TYMS, FPGS, SLC19A1
11edatrexate4411.2TYMS, FPGS, SLC19A1
12lometrexol4411.2TYMS, FPGS, SLC19A1
131843u894411.2TYMS, FPGS, SLC19A1
14b vitamins4411.2MTRR, SHMT1, TYMS
15aminopterin44 1112.2TYMS, FPGS, SLC19A1
16trimetrexate44 1112.2TYMS, FPGS, SLC19A1
17zd93314411.2TYMS, FPGS, SLC19A1
18tomudex4411.2SLC19A1, FPGS, TYMS
19aicar44 11 2413.1SLC19A1, FPGS, TYMS
20methionine4411.1SLC19A1, FPGS, SHMT1, MTRR
21leucovorin44 49 1113.1TYMS, FPGS, SLC19A1
22probenecid44 28 59 49 1115.1SLC19A1, DNTT, TYMS
23pyrimidine44 2412.1FPGS, CDA, TYMS
24Pralatrexate1111.1TYMS, FPGS
25raltitrexed49 1112.1TYMS, FPGS
26metoprine4411.1TYMS, SLC19A1
27ag 3314411.0TYMS, SLC19A1
28pt5234411.0SLC19A1, TYMS
29ag 3374411.0SLC19A1, TYMS
30serine4411.0CDKN2B, TFPT
31hdmtx4411.0SLC19A1, FPGS
32glycinamide ribonucleotide44 1112.0TYMS, FPGS
33gemcitabine44 49 1113.0FPGS, CDA, TYMS
34thiophene4411.0FPGS, TYMS
35deoxyribonucleotide4411.0DNTT, SHMT1
36quinazoline4411.0FPGS, SLC19A1
37p0034411.0CDKN2B, HFE, MTRR
38ara-ctp4411.0CDA, TYMS
395-methyltetrahydrofolate44 1111.9MTRR, SLC19A1
40pteridine4410.9FPGS, SLC19A1
41dttp4410.9TYMS, DNTT
42dcmp44 2411.9TYMS, CDA
43homocysteine44 2411.9SLC19A1, SHMT1, MTRR
44dichloromethane4410.8CDA, TYMS
45Tetrahydrofolic acid11 2411.8FPGS, SHMT1
46s-adenosylmethionine44 11 2412.7SLC19A1, SHMT1, MTRR
47capecitabine44 49 1112.7TYMS, CDA
48deoxyuridine44 2411.7CDA, TYMS
49triphosphate44 2411.6TYMS, DNTT
505-methylthioadenosine4410.4CDKN2B, TYMS

GO Terms for genes affiliated with Childhood Leukemia

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16Gene Ontology
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Cellular components related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.4TFPT, MTRR, SHMT1, TYMS, DNTT, CDKN2B
2ELL-EAF complexGO:03278310.4EAF1, EAF2

Biological processes related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid metabolic processGO:04665510.7SLC19A1, FPGS, SHMT1
2water-soluble vitamin metabolic processGO:00676710.7MTRR, SHMT1, FPGS, SLC19A1
3pyrimidine nucleobase metabolic processGO:00620610.7CDA, TYMS
4vitamin metabolic processGO:00676610.5SLC19A1, FPGS, SHMT1, MTRR

Molecular functions related to Childhood Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00554210.7SLC19A1, TYMS
2protein homodimerization activityGO:04280310.6TPD52L2, TCF3, CDA, TYMS, SHMT1

Products for genes affiliated with Childhood Leukemia

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Sources for Childhood Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet