MCID: CHL061
MIFTS: 50

Childhood Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Childhood Leukemia

MalaCards integrated aliases for Childhood Leukemia:

Name: Childhood Leukemia 12 40 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7757
NCIt 46 C4989
UMLS 69 C1332977

Summaries for Childhood Leukemia

MedlinePlus : 40 Leukemia is cancer of the white blood cells. It is the most common type of childhood cancer. Your blood cells form in your bone marrow. White blood cells help your body fight infection. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. Leukemia can develop quickly or slowly. Acute leukemia is a fast growing type while chronic leukemia grows slowly. Children with leukemia usually have one of the acute types. Symptoms include Infections Fever Loss of appetite Tiredness Easy bruising or bleeding Swollen lymph nodes Night sweats Shortness of breath Pain in the bones or joints Risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. Treatment often cures childhood leukemia. Treatment options include chemotherapy, other drug therapy and radiation. In some cases bone marrow and blood stem cell transplantation might help. NIH: National Cancer Institute

MalaCards based summary : Childhood Leukemia is related to acute lymphoblastic leukemia, childhood and leukemia, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Childhood Leukemia is TCF3 (Transcription Factor 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Doxorubicin Pathway, Pharmacokinetics. The drugs Elliotts B Solution and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are growth/size/body region and hematopoietic system

Disease Ontology : 12 A leukemia that occurs in children.

Wikipedia : 72 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Related Diseases for Childhood Leukemia

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 31.4 ETV6 MTHFR NQO1 RUNX1
2 leukemia 30.4 ETV6 KMT2A MLLT1 MLLT3 PBX1 PTPN11
3 lymphoblastic leukemia 29.6 ARID5B CYP1A1 ETV6 MLLT1 PBX1 RUNX1
4 acute lymphocytic leukemia 29.4 ETV6 MTHFR RUNX1 TP53
5 acute leukemia 28.9 ETV6 KMT2A MLLT1 MLLT3 MTHFR RUNX1
6 leukemia, acute myeloid 28.3 ETV6 KMT2A MLLT1 MLLT3 PTPN11 RUNX1
7 pediatric t-cell leukemia 10.9
8 ring chromosome 21 10.4 ETV6 KMT2A
9 platelet disorder, familial, with associated myeloid malignancy 10.3 ETV6 RUNX1
10 lymphoid leukemia 10.3 ETV6 KMT2A RUNX1
11 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 ETV6 KMT2A RUNX1
12 lymphoma 10.2
13 acute myeloid leukemia with t(9;11)(p22;q23) 10.2 KMT2A MLLT3
14 differentiated thyroid carcinoma 10.1 ETV6 MTHFR TP53
15 cryptogenic cirrhosis 10.1 HFE MTHFR
16 hematologic cancer 10.0 ETV6 KMT2A PTPN11 RUNX1
17 bone marrow cancer 9.9 ETV6 PTPN11 RUNX1
18 aging 9.9
19 hematopoietic stem cell transplantation 9.9
20 leukemia, acute lymphoblastic 3 9.8 ETV6 KMT2A PBX1 RUNX1 TCF3 TP53
21 glucocorticoid resistance, generalized 9.7
22 arthritis 9.7
23 osteonecrosis 9.7
24 cerebritis 9.7
25 influenza 9.7
26 rheumatoid arthritis 9.6
27 down syndrome 9.6
28 hemochromatosis, type 1 9.6
29 lymphoma, hodgkin, classic 9.6
30 lymphoma, non-hodgkin, familial 9.6
31 meningioma, familial 9.6
32 episodic pain syndrome, familial, 1 9.6
33 brain cancer 9.6
34 hereditary wilms' tumor 9.6
35 juvenile rheumatoid arthritis 9.6
36 cytomegalic inclusion disease 9.6
37 back pain 9.6
38 myelodysplastic syndrome 9.5 ETV6 KMT2A NQO1 PTPN11 RUNX1 TFRC
39 leukemia, acute lymphoblastic 9.5 ARID5B ETV6 KMT2A MLLT3 MTHFR PBX1
40 blood group, i system 9.5
41 multiple sclerosis 9.5
42 fibrosis of extraocular muscles, congenital, 1 9.5
43 attention deficit-hyperactivity disorder 9.5
44 hypercalciuria, absorptive, 2 9.5
45 myositis 9.5
46 noonan syndrome 1 9.5
47 sturge-weber syndrome 9.5
48 ataxia-telangiectasia 9.5
49 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.5
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.5

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to Childhood Leukemia

Symptoms & Phenotypes for Childhood Leukemia

UMLS symptoms related to Childhood Leukemia:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Childhood Leukemia:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 MTHFR KMT2A NQO1 PBX1 MLLT3 ACTG1
2 hematopoietic system MP:0005397 10.37 NQO1 PBX1 MLLT1 MLLT3 KMT2A AKR1C3
3 homeostasis/metabolism MP:0005376 10.32 MTHFR KMT2A NQO1 PBX1 HFE AKR1C3
4 cellular MP:0005384 10.3 KMT2A NQO1 HFE ARID5B ETV6 PBX1
5 immune system MP:0005387 10.3 KMT2A NQO1 PBX1 MLLT1 MLLT3 ETV6
6 cardiovascular system MP:0005385 10.22 KMT2A EAF2 ETV6 CYP1A1 PBX1 RUNX1
7 mortality/aging MP:0010768 10.22 KMT2A PBX1 MLLT1 MLLT3 MTHFR EAF2
8 embryo MP:0005380 10.19 KMT2A PBX1 MLLT3 ETV6 RUNX1 PTPN11
9 endocrine/exocrine gland MP:0005379 10.18 EAF2 ARID5B ETV6 CYP1A1 PBX1 RUNX1
10 digestive/alimentary MP:0005381 10.15 PBX1 HFE ACTG1 ARID5B ETV6 PTPN11
11 integument MP:0010771 10.13 MTHFR KMT2A NQO1 PBX1 EAF2 ETV6
12 liver/biliary system MP:0005370 10.11 NQO1 PBX1 MLLT1 KMT2A CYP1A1 HFE
13 limbs/digits/tail MP:0005371 10.01 MTHFR KMT2A PBX1 ARID5B HFE PTPN11
14 neoplasm MP:0002006 9.96 KMT2A NQO1 MLLT1 MLLT3 EAF2 ETV6
15 no phenotypic analysis MP:0003012 9.9 KMT2A MLLT3 MTHFR ETV6 CYP1A1 HFE
16 normal MP:0002873 9.7 KMT2A PBX1 MLLT1 ETV6 CYP1A1 HFE
17 reproductive system MP:0005389 9.28 MTHFR KMT2A PBX1 EAF2 AKR1C3 ARID5B

Drugs & Therapeutics for Childhood Leukemia

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Elliotts B Solution 17 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical October 1996

Drugs for Childhood Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Thioguanine Approved Phase 4,Phase 1 154-42-7 2723601
3 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
4 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
5 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
6 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
7 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
8 6-Mercaptopurine Phase 4,Phase 1
9
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
10
Cytarabine Approved, Investigational Phase 3,Phase 1,Phase 2 147-94-4 6253
11
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 50-02-2 5743
12
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2 23214-92-8 31703
13
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
14
Hydrocortisone Approved, Vet_approved Phase 3,Phase 1 50-23-7 657311 5754
15
Ifosfamide Approved Phase 3 3778-73-2 3690
16
Levoleucovorin Approved, Investigational Phase 3,Phase 1 68538-85-2
17
Methotrexate Approved Phase 3,Phase 1,Phase 2,Early Phase 1 1959-05-2, 59-05-2 126941
18
Vinblastine Approved Phase 3 865-21-4 241903 13342
19 Thiotepa Approved, Investigational Phase 3 52-24-4 5453
20
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
21
alemtuzumab Approved, Investigational Phase 3 216503-57-0
22
Chlorambucil Approved Phase 3 305-03-3 2708
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 59-30-3 6037
24
leucovorin Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Early Phase 1 58-05-9 143 6006
25
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
27
Butyric Acid Experimental, Investigational Phase 3,Phase 1 107-92-6 264
28
Doxil Approved June 1999 Phase 3,Phase 1,Phase 2 31703
29 Alkylating Agents Phase 3,Phase 2,Phase 1
30 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
31 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
32 Antidotes Phase 3
33 Antiemetics Phase 3,Phase 1,Phase 2
34 Anti-Infective Agents Phase 3,Phase 1,Phase 2
35 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
36 Antimitotic Agents Phase 3,Phase 1,Phase 2
37 Antineoplastic Agents, Hormonal Phase 3,Phase 1,Phase 2
38 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
39 Antiviral Agents Phase 3,Phase 1,Phase 2
40 Autonomic Agents Phase 3,Phase 1,Phase 2
41 BB 1101 Phase 3,Phase 1,Phase 2,Early Phase 1
42 Calcium, Dietary Phase 3,Phase 1
43 Cortisol succinate Phase 3,Phase 1
44 Dermatologic Agents Phase 3,Phase 1,Phase 2,Early Phase 1
45 Dexamethasone acetate Phase 3,Phase 1,Phase 2,Early Phase 1 1177-87-3
46 Etoposide phosphate Phase 3,Phase 2,Phase 1
47 Folic Acid Antagonists Phase 3,Phase 1,Phase 2,Early Phase 1
48 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
49 glucocorticoids Phase 3,Phase 1,Phase 2
50 Hormone Antagonists Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 52)

# Name Status NCT ID Phase Drugs
1 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
2 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;therapeutic hydrocortisone;vinblastine sulfate
3 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3 Chemotherapy and antibodies
4 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
5 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
6 Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) Completed NCT00440726 Phase 1, Phase 2 bortezomib (Velcade);dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;vincristine
7 T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML) Terminated NCT00939653 Phase 2 clofarabine;etoposide;cyclophosphamide;filgrastim;cytarabine
8 A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Terminated NCT01483690 Phase 1, Phase 2 Decitabine;Vorinostat;Vincristine;Dexamethasone;Mitoxantrone;Pegaspargase;Methotrexate
9 Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia Terminated NCT01158885 Phase 2 Clofarabine;Cytarabine;Methotrexate;Cytarabine
10 Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Terminated NCT00981799 Phase 1, Phase 2 Nelarabine;Etoposide;Cyclophosphamide;Methotrexate;Filgrastim
11 Study of IRNEA (Irinotecan, Etoposide, Cytarabine) for Refractory or Relapsed Acute Leukemia in Children and Adolescents Unknown status NCT01239485 Phase 1 Irinotecan
12 Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. Completed NCT01041508 Phase 1 Clofarabine;Cyclosporins;Mycophenolate mofetil
13 Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies Completed NCT01900509 Phase 1 Bendamustine;Clofarabine;Etoposide;Etoposide phosphate;Dexamethasone
14 A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML Completed NCT01861002 Phase 1 Azacytidine;Fludarabine;Cytarabine
15 A Phase I Study of AC220 for Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia Completed NCT01411267 Phase 1 AC220;Cytarabine;Etoposide;Methotrexate
16 A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Completed NCT01321346 Phase 1 Panobinostat;Cytarabine;Panobinostat
17 Monitoring and Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children Recruiting NCT02484261 Phase 1 Bortezomib;Pravastatin
18 Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome Recruiting NCT02676323 Phase 1 Panobinostat;Fludarabine;Cytarabine;Intrathecal Triples;Leucovorin
19 Epigenetic Reprogramming in Relapse/Refractory AML Recruiting NCT03263936 Phase 1 Decitabine;Vorinostat;Filgrastim (G-CSF);Fludarabine;Cytarabine
20 Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL Recruiting NCT02879643 Phase 1 Marqibo in combination with UK ALL R3
21 A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma Recruiting NCT01614197 Phase 1 Temsirolimus;Etoposide;Etoposide;Cyclophosphamide;Methotrexate;Hydrocortisone;Cytarabine
22 Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia Recruiting NCT02303821 Phase 1 Carfilzomib;Dexamethasone;Mitoxantrone;PEG-asparaginase;Vincristine;Intrathecal (IT) Methotrexate;Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate);6-Mercaptopurine;Cyclophosphamide;Cytarabine;Daunorubicin
23 Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML Recruiting NCT02091245 Phase 1 KPT-330
24 Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) Terminated NCT00928200 Phase 1 Erwinase;Vincristine;Dexamethasone;Doxorubicin;Cytarabine;Methotrexate;Triple Intrathecal Therapy
25 ABT-751 With Chemotherapy for Relapsed Pediatric ALL Terminated NCT00439296 Phase 1 ABT-751;dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;cyclophosphamide;6-thioguanine
26 Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia Terminated NCT01743807 Phase 1 GNKG168
27 EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) Terminated NCT01186328 Phase 1 EZN-3042;Cytarabine;Doxorubicin;Prednisone;Vincristine;Pegaspargase;Methotrexate
28 Prevalence of Psychocognitive Impairments in Adolescents Surviving Childhood Leukemia : LEA-PsyCog Unknown status NCT01741662
29 The Metabolic Syndrome Among Leukemia Survivors: Physiopathological Analysis Unknown status NCT02696304
30 A Drug Monitoring Study on PEG-asparaginase Treatment in Children Diagnosed Acute Lymphoblastic Leukaemia Unknown status NCT01272440
31 Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study Unknown status NCT02644044 Early Phase 1 Intrathecal methotrexate
32 Implementation of Innovative Techniques in Routine Diagnosis of Childhood Acute Leukemia: Analysis of Genome and Transcriptome by Micro-array Unknown status NCT02038361
33 Case-Control Study of Pesticides and Childhood Leukemia Completed NCT00342888
34 Molecular Epidemiology of Childhood Leukemia (Aka The California Childhood Leukemia Study) Completed NCT00015587
35 PACE-CALL: A Weight Control Intervention for Survivors of Childhood Leukemia Completed NCT01171599
36 Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell Transplant Completed NCT00920842
37 Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia Completed NCT02528435
38 Urban Environmental Exposures and Childhood Cancer Completed NCT00505141
39 PACE CALL: Weight Loss Study for Childhood Leukemia Survivors Completed NCT01253720
40 Pharmacokinetics of Asparaginase and Antibody Formation in Interfant-06 Completed NCT01025804
41 Aerobic and Strengthening Exercise for Acute Leukemia Completed NCT00766311
42 Zometa Study in Pediatric Acute Lymphoblastic Leukemia Completed NCT01656512 zolendronic acid;calcium & vitamin D
43 N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors Recruiting NCT01913093
44 Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome Recruiting NCT02859389
45 Multi-centre Prospective Cohort of Childhood Leukaemia: Determinants of Health and Quality of Life of the Patients After Treatment for an Acute Leukaemia During Childhood or Adolescence - LEA Recruiting NCT01756599
46 Comparing the Impact of Cancer on Quality of Life Between Survivors of Childhood Solid Tumors and Leukemia Recruiting NCT03430752
47 Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL) Recruiting NCT01094392
48 PRecISion Medicine for Children With Cancer Recruiting NCT03336931
49 Exercise and QUality Diet After Leukemia: The EQUAL Study Active, not recruiting NCT02244411
50 Symptom Clusters in Children With Leukemia Enrolling by invitation NCT01708421

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

MalaCards organs/tissues related to Childhood Leukemia:

38
Bone, Bone Marrow, Heart, Lymph Node, Brain, T Cells, B Cells

Publications for Childhood Leukemia

Articles related to Childhood Leukemia:

(show top 50) (show all 660)
# Title Authors Year
1
Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors' cohort: A comparison with controls from the French population. ( 29351982 )
2018
2
A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from TACL consortium. ( 29339403 )
2018
3
Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. ( 29105081 )
2018
4
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
5
Neurocognitive Consequences of Childhood Leukemia and Its Treatment. ( 29398801 )
2018
6
Residential Proximity to Gasoline Stations and Risk of Childhood Leukemia. ( 27923798 )
2017
7
Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion. ( 28129329 )
2017
8
Comparative analyses of studies of childhood leukemia and magnetic fields, radon and gamma radiation. ( 28586320 )
2017
9
Brain structure, working memory and response inhibition in childhood leukemia survivors. ( 28239531 )
2017
10
Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies. ( 29099685 )
2017
11
Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing. ( 28154091 )
2017
12
Geographical Distribution and Cluster Detection of Childhood Leukemia in the Metropolitan Area of Guadalajara, Mexico. ( 28613286 )
2017
13
TACL'ing supportive care needs in pediatric early phase clinical trials for acute leukemia: A report from the therapeutic advances in childhood leukemia & lymphoma (TACL) consortium supportive care committee. ( 29190169 )
2017
14
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia. ( 27726029 )
2017
15
Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. ( 28900736 )
2017
16
Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL): Overview and introduction to the proceedings of the 2016 TACL investigator meeting. ( 29120691 )
2017
17
Early vaccination protects against childhood leukemia: A systematic review and meta-analysis. ( 29167460 )
2017
18
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. ( 27783932 )
2017
19
Microstructure alterations in the Hypothalamus in cranially radiated Childhood Leukemia survivors but not in Craniopharyngioma patients unaffected by hypothalamic damage. ( 28502079 )
2017
20
Infectious Agents in Childhood Leukemia. ( 29157671 )
2017
21
Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. ( 28169879 )
2017
22
Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Nonmyeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia Consortium Study. ( 28396162 )
2017
23
The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia. ( 29102926 )
2017
24
Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group. ( 29190164 )
2017
25
Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia. ( 29187444 )
2017
26
Clinical Presentation, Prognostic Factors, and Outcome in Neutropenic Enteropathy of Childhood Leukemia. ( 29293190 )
2017
27
Immune Dysfunction After Completion of Childhood Leukemia Therapy. ( 27820131 )
2017
28
Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster. ( 28446785 )
2017
29
Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study. ( 28850735 )
2017
30
Aberrant AML1 gene expression in the diagnosis of childhood leukemias not characterized by AML1-involved cytogenetic abnormalities. ( 28349830 )
2017
31
Trends in childhood leukemia incidence over two decades from 1992 to 2013. ( 27778348 )
2017
32
Novel agents for the treatment of childhood leukemia: an update. ( 28740405 )
2017
33
Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. ( 29017430 )
2017
34
50 Years Ago in The Journal of Pediatrics: Prevention and Management of Acute Hyperuricemia in Childhood Leukemia. ( 29173302 )
2017
35
Impact of Ego-resilience and Family Function on Quality of Life in Childhood Leukemia Survivors. ( 28032062 )
2016
36
Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy. ( 28476197 )
2016
37
Preterm Birth and Subsequent Risk of Acute Childhood Leukemia: a Meta-Analysis of Observational Studies. ( 27595399 )
2016
38
A review of risk factors for childhood leukemia. ( 27735044 )
2016
39
Early childhood leukemia incidence trends in Brazil. ( 26925506 )
2016
40
Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. ( 26941364 )
2016
41
Childhood leukemia incidence in California: High and rising in the Hispanic population. ( 27351365 )
2016
42
Associations between Metabolic Risk Factors and the Hypothalamic Volume in Childhood Leukemia Survivors Treated with Cranial Radiotherapy. ( 26824435 )
2016
43
Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study. ( 27318855 )
2016
44
Residential mobility and the risk of childhood leukemia. ( 26830898 )
2016
45
Acute childhood leukemia in India: Where are we going, where have we been? ( 27606303 )
2016
46
Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group. ( 26914030 )
2016
47
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. ( 26755588 )
2016
48
Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. ( 27294727 )
2016
49
Environmental Exposure and Risk of Childhood Leukemia: An Overview. ( 28476188 )
2016
50
Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium. ( 27492895 )
2016

Variations for Childhood Leukemia

Expression for Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for Childhood Leukemia

Pathways related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 ETV6 KMT2A MLLT1 MLLT3 PBX1 RUNX1
2
Show member pathways
10.73 AKR1C3 NQO1 TP53

GO Terms for Childhood Leukemia

Cellular components related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ARID5B EAF2 KMT2A MLLT1 MLLT3 PBX1
2 HFE-transferrin receptor complex GO:1990712 9.16 HFE TFRC
3 transcription elongation factor complex GO:0008023 8.8 EAF2 MLLT1 MLLT3
4 nucleus GO:0005634 10.1 ACTG1 AKR1C3 ARID5B EAF2 ETV6 KMT2A

Biological processes related to Childhood Leukemia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.9 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.87 EAF2 ETV6 KMT2A PBX1 RUNX1 TCF3
3 positive regulation of transcription, DNA-templated GO:0045893 9.73 EAF2 KMT2A MLLT3 RUNX1 TCF3 TP53
4 transcription, DNA-templated GO:0006351 9.7 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
5 regulation of hematopoietic stem cell differentiation GO:1902036 9.63 KMT2A RUNX1 TCF3
6 anterior/posterior pattern specification GO:0009952 9.61 KMT2A MLLT3 PBX1
7 transcription elongation from RNA polymerase II promoter GO:0006368 9.58 EAF2 MLLT1 MLLT3
8 adrenal gland development GO:0030325 9.51 ARID5B PBX1
9 response to hyperoxia GO:0055093 9.49 CYP1A1 TP53
10 embryonic hemopoiesis GO:0035162 9.48 KMT2A PBX1
11 hematopoietic stem cell proliferation GO:0071425 9.37 ETV6 RUNX1
12 transcription by RNA polymerase II GO:0006366 9.23 EAF2 ETV6 KMT2A MLLT1 MLLT3 PBX1

Molecular functions related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 ACTG1 ARID5B C1QC CYP1A1 EAF2 ETV6
2 DNA binding GO:0003677 9.81 ARID5B ETV6 KMT2A MLLT1 PBX1 RUNX1
3 transcription regulatory region DNA binding GO:0044212 9.56 ARID5B KMT2A RUNX1 TP53
4 lysine-acetylated histone binding GO:0070577 9.32 KMT2A MLLT3
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.1 ARID5B EAF2 ETV6 PBX1 RUNX1 TP53

Sources for Childhood Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....