MCID: CHL061
MIFTS: 48

Childhood Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Childhood Leukemia

MalaCards integrated aliases for Childhood Leukemia:

Name: Childhood Leukemia 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7757
NCIt 47 C4989
UMLS 69 C1332977

Summaries for Childhood Leukemia

MedlinePlus : 41 leukemia is cancer of the white blood cells. it is the most common type of childhood cancer. your blood cells form in your bone marrow. white blood cells help your body fight infection. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. leukemia can develop quickly or slowly. acute leukemia is a fast growing type while chronic leukemia grows slowly. children with leukemia usually have one of the acute types. symptoms include infections fever loss of appetite tiredness easy bruising or bleeding swollen lymph nodes night sweats shortness of breath pain in the bones or joints risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. treatment often cures childhood leukemia. treatment options include chemotherapy, other drug therapy and radiation. in some cases bone marrow and blood stem cell transplantation might help. nih: national cancer institute

MalaCards based summary : Childhood Leukemia is related to leukemia and pediatric t-cell leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Childhood Leukemia is TCF3 (Transcription Factor 3), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Elliotts B Solution and Asparaginase have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are growth/size/body region and hematopoietic system

Disease Ontology : 12 A leukemia that occurs in children.

Wikipedia : 72 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Related Diseases for Childhood Leukemia

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 leukemia 10.8
2 pediatric t-cell leukemia 10.8
3 ring chromosome 5 10.6 ETV6 KMT2A
4 deafness, autosomal recessive 8/10 10.6 ETV6 RUNX1
5 lymphoma, small cleaved-cell, diffuse 10.5 ETV6 KMT2A RUNX1
6 acute necrotizing encephalopathy 10.5 ETV6 KMT2A RUNX1
7 familial bicuspid aortic valve 10.4 KMT2A MLLT3
8 timothy syndrome type 2 10.4 HFE TFRC
9 non-distal trisomy 10q 10.3 ETV6 MTHFR TP53
10 acute myocardial infarction 10.3 ETV6 MTHFR RUNX1 TP53
11 myopia, autosomal 10.1 KMT2A MLLT1 MLLT3
12 lymphoma 10.1
13 acute monocytic leukemia 10.1 ETV6 MTHFR NQO1 RUNX1
14 lymphoblastic leukemia 10.1
15 gastric cancer, somatic 10.1 MTHFR RUNX1 TP53
16 nelson syndrome 10.1 ETV6 PTPN11 RUNX1
17 hemolytic anemia 10.1 ETV6 KMT2A PTPN11 RUNX1
18 astrocytoma 10.1 CYP1A1 TP53
19 septicemic plague 10.0 CYP1A1 NQO1 TP53
20 preeclampsia/eclampsia 3 9.9 ETV6 KMT2A PBX1 RUNX1 TCF3 TP53
21 hematopoietic stem cell transplantation 9.8
22 glucocorticoid resistance 9.7
23 arthritis 9.7
24 cerebritis 9.7
25 influenza 9.7
26 rheumatoid arthritis 9.6
27 hodgkin lymphoma 9.6
28 hemochromatosis 9.6
29 osteonecrosis 9.6
30 brain cancer 9.6
31 cytomegalic inclusion disease 9.6
32 back pain 9.6
33 leukemia, acute myeloid 9.5 ETV6 KMT2A NQO1 PTPN11 RUNX1 TFRC
34 suppression amblyopia 9.4 ARID5B CYP1A1 ETV6 MLLT1 PBX1 RUNX1
35 acute lymphoblastic leukemia, childhood 9.4 ETV6 KMT2A MLLT1 MLLT3 MTHFR RUNX1
36 liver cirrhosis 9.4 ETV6 MLLT1 MLLT3 PBX1 PTPN11 RUNX1
37 obesity 9.4
38 attention deficit-hyperactivity disorder 9.4
39 ataxia-telangiectasia 9.4
40 down syndrome 9.4
41 acute leukemia 9.4
42 acute lymphocytic leukemia 9.4
43 hemophagocytic lymphohistiocytosis 9.4
44 hepatitis 9.4
45 severe combined immunodeficiency 9.4
46 thrombosis 9.4
47 osteomyelitis 9.4
48 gastric ulcer 9.4
49 pericardial effusion 9.4
50 testicular leukemia 9.4

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to Childhood Leukemia

Symptoms & Phenotypes for Childhood Leukemia

UMLS symptoms related to Childhood Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Childhood Leukemia:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 MLLT3 MTHFR NQO1 PBX1 PTPN11 RUNX1
2 hematopoietic system MP:0005397 10.37 ARID5B CYP1A1 ETV6 HFE KMT2A MLLT1
3 homeostasis/metabolism MP:0005376 10.32 AKR1C3 ARID5B CYP1A1 ETV6 HFE KMT2A
4 cellular MP:0005384 10.3 TP53 PTPN11 RUNX1 TCF3 TFRC ARID5B
5 immune system MP:0005387 10.3 ARID5B CYP1A1 ETV6 HFE KMT2A MLLT1
6 cardiovascular system MP:0005385 10.22 CYP1A1 EAF2 ETV6 KMT2A PBX1 PTPN11
7 mortality/aging MP:0010768 10.22 ACTG1 ARID5B CYP1A1 EAF2 ETV6 HFE
8 embryo MP:0005380 10.19 TFRC TP53 ETV6 KMT2A MLLT3 PBX1
9 endocrine/exocrine gland MP:0005379 10.18 ARID5B CYP1A1 EAF2 ETV6 PBX1 PTPN11
10 integument MP:0010771 10.17 PBX1 PTPN11 RUNX1 TCF3 TFRC TP53
11 digestive/alimentary MP:0005381 10.15 ACTG1 ARID5B ETV6 HFE PBX1 PTPN11
12 liver/biliary system MP:0005370 10.11 CYP1A1 HFE KMT2A MLLT1 NQO1 PBX1
13 limbs/digits/tail MP:0005371 10.01 ARID5B HFE KMT2A MTHFR PBX1 PTPN11
14 neoplasm MP:0002006 9.96 EAF2 ETV6 KMT2A MLLT1 MLLT3 NQO1
15 no phenotypic analysis MP:0003012 9.9 MLLT3 MTHFR PTPN11 RUNX1 TCF3 TFRC
16 normal MP:0002873 9.7 TFRC TP53 CYP1A1 ETV6 HFE KMT2A
17 reproductive system MP:0005389 9.28 AKR1C3 ARID5B EAF2 KMT2A MTHFR PBX1

Drugs & Therapeutics for Childhood Leukemia

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Elliotts B Solution 17 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical October 1996

Drugs for Childhood Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 360)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
3
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
7
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
8
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
11
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
12
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
15
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
16
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
17
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
18
Oprelvekin Approved, Investigational Phase 4 145941-26-0
19
Arsenic trioxide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1327-53-3 518740
20
Azathioprine Approved Phase 4 446-86-6 2265
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
22
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
23
Tretinoin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 302-79-4 5538
24
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
25 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
27 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1177-87-3
29 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
30 Antibodies Phase 4,Phase 3,Phase 1,Phase 2
31
Ethylene Phase 4 74-85-1 6325
32 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2
33 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
34 Hormones Phase 4,Phase 3,Phase 2,Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
36 Imatinib Mesylate Phase 4,Phase 3,Phase 2,Phase 1 123596
37 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
41 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
42 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
44 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
45 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
47
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
48 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
49 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 556)

id Name Status NCT ID Phase Drugs
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
2 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
5 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
6 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
7 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
8 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
9 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
10 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
11 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
12 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
13 A Study for Improving the Outcome of Childhood Acute Promyeloid Leukemia Enrolling by invitation NCT02200978 Phase 4 ATO;RIF;ATRA;mitoxantrone;Ara-C;MTX;6MP
14 Treating Patients With Childhood Acute Myeloid Leukemia With Interleukin-2 Unknown status NCT00149162 Phase 3 proleukin
15 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
16 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;therapeutic hydrocortisone;vinblastine sulfate
17 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
18 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
19 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
20 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
21 Donor Stem Cell Transplant With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome Unknown status NCT00047268 Phase 3 cytarabine;mercaptopurine
22 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
23 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;prednisone;vincristine sulfate
24 Imatinib Mesylate With or Without Interferon Alfa or Cytarabine Compared With Interferon Alfa Followed by Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia Unknown status NCT00055874 Phase 3 cytarabine;hydroxyurea;imatinib mesylate
25 Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, Stage II, or Stage III Childhood Liver Cancer Unknown status NCT00652132 Phase 3 cisplatin;sodium thiosulfate
26 Chemotherapy, Interferon, and Bone Marrow Transplantation in Treating Patients With Chronic Myelogenous Leukemia Unknown status NCT00002771 Phase 3 busulfan;cytarabine;hydroxyurea;idarubicin
27 Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia Unknown status NCT00025402 Phase 3 busulfan;cyclophosphamide;cytarabine;etoposide;hydroxyurea;idarubicin
28 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
29 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia Unknown status NCT00002926 Phase 3 cytarabine;etoposide;idarubicin
30 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
31 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
32 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3 Chemotherapy and antibodies
33 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
34 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia Completed NCT00866918 Phase 3 arsenic trioxide;mitoxantrone hydrochloride;idarubicin;tretinoin;cytarabine;mercaptopurine tablet;methotrexate
35 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3 cytarabine;dexamethasone;etoposide;idarubicin;ifosfamide;leucovorin calcium;mesna;pegaspargase;therapeutic hydrocortisone;thioguanine;vincristine sulfate;Methotrexate
36 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
37 Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia Completed NCT00015873 Phase 3 asparaginase;cytarabine;mercaptopurine;methotrexate;prednisolone;vincristine sulfate
38 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
39 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia Completed NCT00003436 Phase 3 amsacrine;asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;methotrexate;mitoxantrone hydrochloride;therapeutic hydrocortisone
40 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase Completed NCT00819351 Phase 3 PEG Asparaginase at six weeks interval;PEG Asparaginase at two weeks interval
41 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3 dexamethasone;asparaginase;Asparaginase;cyclophosphamide;cytarabine;daunorubicin;doxorubicin;Etoposide;Ifosfamide;mercaptopurine;Methotrexate;prednisone;thioguanine;Vincristine;Vindesine
42 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
43 Treatment of Children and Adolescents With Refractory or Relapsed Acute Myeloid Leukemia Completed NCT00186966 Phase 3 Fludarabine, Cytarabine, Liposomal daunorubicin (DaunoXome);Etoposide, Thioguanine, Cyclophosphamide, Busulfan, Melphalan
44 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
45 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
46 Sleep, Fatigue, and Dexamethosone in Children With Leukemia Completed NCT00075101 Phase 3 Dexamethosone
47 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
48 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
49 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00005596 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
50 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002744 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

MalaCards organs/tissues related to Childhood Leukemia:

39
Myeloid, Bone, Bone Marrow, T Cells, B Cells, Brain, Heart

Publications for Childhood Leukemia

Articles related to Childhood Leukemia:

(show top 50) (show all 644)
id Title Authors Year
1
Novel agents for the treatment of childhood leukemia: an update. ( 28740405 )
2017
2
Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster. ( 28446785 )
2017
3
Comparative analyses of studies of childhood leukemia and magnetic fields, radon and gamma radiation. ( 28586320 )
2017
4
Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Nonmyeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia Consortium Study. ( 28396162 )
2017
5
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. ( 27783932 )
2017
6
Brain structure, working memory and response inhibition in childhood leukemia survivors. ( 28239531 )
2017
7
Trends in childhood leukemia incidence over two decades from 1992 to 2013. ( 27778348 )
2017
8
Microstructure alterations in the Hypothalamus in cranially radiated Childhood Leukemia survivors but not in Craniopharyngioma patients unaffected by hypothalamic damage. ( 28502079 )
2017
9
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia. ( 27726029 )
2017
10
Residential Proximity to Gasoline Stations and Risk of Childhood Leukemia. ( 27923798 )
2017
11
Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. ( 28169879 )
2017
12
Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study. ( 28850735 )
2017
13
Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. ( 28900736 )
2017
14
Aberrant AML1 gene expression in the diagnosis of childhood leukemias not characterized by AML1-involved cytogenetic abnormalities. ( 28349830 )
2017
15
Immune Dysfunction After Completion of Childhood Leukemia Therapy. ( 27820131 )
2017
16
Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing. ( 28154091 )
2017
17
Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion. ( 28129329 )
2017
18
Geographical Distribution and Cluster Detection of Childhood Leukemia in the Metropolitan Area of Guadalajara, Mexico. ( 28613286 )
2017
19
Incidence and survival of childhood leukemia in Recife, Brazil: A population-based analysis. ( 28000427 )
2016
20
Associations between Metabolic Risk Factors and the Hypothalamic Volume in Childhood Leukemia Survivors Treated with Cranial Radiotherapy. ( 26824435 )
2016
21
Early Posttherapy Hospitalizations Among Survivors of Childhood Leukemia and Lymphoma. ( 26925709 )
2016
22
A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California. ( 27494537 )
2016
23
Foreword: Childhood Leukemia and Primary Prevention. ( 27968953 )
2016
24
Preterm Birth and Subsequent Risk of Acute Childhood Leukemia: a Meta-Analysis of Observational Studies. ( 27595399 )
2016
25
Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study. ( 27318855 )
2016
26
Acute childhood leukemia in India: Where are we going, where have we been? ( 27606303 )
2016
27
Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis. ( 26589707 )
2016
28
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. ( 26755588 )
2016
29
Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community. ( 27693118 )
2016
30
Home remodeling and risk of childhood leukemia. ( 28065451 )
2016
31
Breastfeeding, Other Early Life Exposures and Childhood Leukemia and Lymphoma. ( 27352124 )
2016
32
Significant Association of Interleukin-10 Polymorphisms with Childhood Leukemia Susceptibility in Taiwan. ( 27107085 )
2016
33
A review of risk factors for childhood leukemia. ( 27735044 )
2016
34
Childhood Leukemia and Primary Prevention. ( 27968954 )
2016
35
Impact of Ego-resilience and Family Function on Quality of Life in Childhood Leukemia Survivors. ( 28032062 )
2016
36
Genetic abnormalities associated with the relapse of childhood leukemia. ( 27498739 )
2016
37
A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study. ( 27271226 )
2016
38
Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). ( 27063976 )
2016
39
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia. ( 26708601 )
2016
40
Matrix Metalloproteinase-1 Genotype Contributes to the Risk of Non-solid Tumor in Childhood Leukemia. ( 27798872 )
2016
41
Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy. ( 28476197 )
2016
42
Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk. ( 27054704 )
2016
43
A Phase I Study of Quizartinib Combined With Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. ( 26920889 )
2016
44
Childhood leukemia incidence in California: High and rising in the Hispanic population. ( 27351365 )
2016
45
Residential mobility and the risk of childhood leukemia. ( 26830898 )
2016
46
Addressing behavioral impacts of childhood leukemia: A feasibility pilot randomized controlled trial of a group videoconferencing parenting intervention. ( 27697278 )
2016
47
Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study. ( 27858183 )
2016
48
Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium. ( 26991812 )
2016
49
Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. ( 27294727 )
2016
50
Copy Number Alterations Associated with Acute Lymphoblastic Leukemia in Mexican Children. A report from The Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia. ( 28476198 )
2016

Variations for Childhood Leukemia

Expression for Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for Childhood Leukemia

Pathways related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.95 NQO1 PBX1 RUNX1 TCF3
2 11.48 ETV6 KMT2A MLLT1 MLLT3 PBX1 RUNX1
3
Show member pathways
10.73 AKR1C3 NQO1 TP53

GO Terms for Childhood Leukemia

Cellular components related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.65 ARID5B EAF2 KMT2A MLLT1 MLLT3 PBX1
2 HFE-transferrin receptor complex GO:1990712 9.16 HFE TFRC
3 transcription elongation factor complex GO:0008023 8.8 EAF2 MLLT1 MLLT3
4 nucleus GO:0005634 10.1 ACTG1 AKR1C3 ARID5B EAF2 ETV6 KMT2A

Biological processes related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.9 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.87 EAF2 ETV6 KMT2A PBX1 RUNX1 TCF3
3 transcription, DNA-templated GO:0006351 9.7 ARID5B EAF2 ETV6 KMT2A MLLT1 MLLT3
4 positive regulation of transcription, DNA-templated GO:0045893 9.65 EAF2 KMT2A RUNX1 TCF3 TP53
5 anterior/posterior pattern specification GO:0009952 9.58 KMT2A MLLT3 PBX1
6 transcription elongation from RNA polymerase II promoter GO:0006368 9.54 EAF2 MLLT1 MLLT3
7 embryonic hemopoiesis GO:0035162 9.46 KMT2A PBX1
8 hematopoietic stem cell proliferation GO:0071425 9.43 ETV6 RUNX1
9 transcription from RNA polymerase II promoter GO:0006366 9.23 EAF2 ETV6 KMT2A MLLT1 MLLT3 PBX1
10 adrenal gland development GO:0030325 9.18 PBX1

Molecular functions related to Childhood Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.61 ARID5B ETV6 KMT2A MLLT1 PBX1 RUNX1
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 ARID5B EAF2 ETV6 RUNX1 TP53
3 lysine-acetylated histone binding GO:0070577 8.96 KMT2A
4 protein binding GO:0005515 10.09 ACTG1 ARID5B CYP1A1 EAF2 ETV6 HFE

Sources for Childhood Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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