MCID: CHL018
MIFTS: 42

Childhood Medulloblastoma malady

Rare diseases, Cancer diseases categories
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Summaries for Childhood Medulloblastoma

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MalaCards: Childhood Medulloblastoma, also known as medulloblastoma, childhood, is related to medulloblastoma and primitive neuroectodermal tumor. An important gene associated with Childhood Medulloblastoma is BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)), and among its related pathways are Neural Crest Differentiation and ErbB signaling pathway. The compounds hrgbeta1 and 15-deoxy-delta-12,14-prostaglandin j2 have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thyroid, and related mouse phenotypes are pigmentation and tumorigenesis.

Aliases & Classifications for Childhood Medulloblastoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS, 45Novoseek, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

childhood medulloblastoma 8 43 10
medulloblastoma, childhood 43 62
pediatric medulloblastoma 8
medulloblastoma childhood 45


External Ids:

Disease Ontology8 DOID:3869
NCIt40 C3997
MeSH35 D008527

Related Diseases for Childhood Medulloblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Childhood Medulloblastoma:



Diseases related to childhood medulloblastoma

Symptoms for Childhood Medulloblastoma

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Drugs & Therapeutics for Childhood Medulloblastoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Childhood Medulloblastoma

Search NIH Clinical Center for Childhood Medulloblastoma

Genetic Tests for Childhood Medulloblastoma

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Anatomical Context for Childhood Medulloblastoma

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33MalaCards
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MalaCards organs/tissues related to Childhood Medulloblastoma:

33
Bone, Brain, Thyroid, Testes, Parietal lobe

Animal Models for Childhood Medulloblastoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Childhood Medulloblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9ERBB3, MYC, TFAP2A
2MP:00020068.4EPHX1, MYC, BAP1, ERBB3
3MP:00053818.4TFAP2A, MYC, SSTR2, ERBB3
4MP:00053808.3TFAP2A, MYC, BAP1, ERBB3
5MP:00053858.1ERBB3, BAP1, SSTR2, MYC, TFAP2A
6MP:00053767.7ERBB3, BAP1, SSTR2, MYC, EPHX1

Publications for Childhood Medulloblastoma

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52PubMed
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Articles related to Childhood Medulloblastoma:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. (24276042)
2014
2
A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma. (23292496)
2013
3
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. (22054800)
2012
4
Chemotherapy dose-intensity and survival for childhood medulloblastoma. (22993333)
2012
5
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile. (22826514)
2012
6
Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cells. (22980291)
2012
7
Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. (23095827)
2012
8
Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study. (22994552)
2012
9
An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. (22389292)
2012
10
A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. (22153558)
2012
11
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. (21317922)
2011
12
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes. (21367970)
2011
13
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)
2010
14
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. (20978505)
2010
15
Childhood medulloblastoma: current status of biology and treatment. (20297854)
2010
16
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone-a critical review. (20689605)
2009
17
Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers. (19221477)
2009
18
Examination of somatostatin receptor expression in recurrent childhood medulloblastomas]. (19068462)
2008
19
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. (17254356)
2007
20
Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. (17473196)
2007
21
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. (17601681)
2007
22
The results of the treatment of childhood medulloblastoma with radiotherapy at Kaunas University of Medicine Hospital in 1994-2000. (16467610)
2006
23
Current treatment approaches to early childhood medulloblastoma. (16893348)
2006
24
Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. (15937648)
2005
25
Retrospective family study of childhood medulloblastoma. (15759260)
2005
26
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. (16258095)
2005
27
Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. (16110011)
2005
28
Prognostic significance of anaplasia and angiogenesis in childhood medulloblastoma: a pediatric oncology group study. (15462497)
2004
29
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
30
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. (14695141)
2003
31
Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. (11990307)
2002
32
Expression of C-myc and N-myc protein in adulthood and childhood medulloblastomas and prognostic analysis]. (12733375)
2001
33
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. (11391800)
2001
34
Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. (11483340)
2001
35
Ophthalmic complications of childhood medulloblastoma. (10611584)
2000
36
Childhood medulloblastoma in Denmark 1960-1984. A population-based retrospective study. (10066017)
1999
37
Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. (9893634)
1998
38
Expression of the c-Myc protein in childhood medulloblastoma. (9482408)
1998
39
Mitotic percentage index: a new prognostic factor for childhood medulloblastoma. (9274443)
1997
40
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. (9307291)
1997
41
Chemotherapy for Childhood Medulloblastoma and Primitive Neuroectodermal Tumors. (10388020)
1996
42
No preferential loss of one parental allele of chromosome 17p13.3 in childhood medulloblastoma. (7591234)
1995
43
Radiotherapy and adjuvant chemotherapy for childhood medulloblastoma. The Royal Marsden Hospital experience. (7502224)
1995
44
Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. (8043463)
1994
45
Partial transmission block radiotherapy technique for childhood medulloblastoma. (8428261)
1993
46
Childhood medulloblastoma. (1448667)
1992
47
DNA content and other prognostic features in childhood medulloblastoma. Proposal of a scoring system. (1739930)
1992
48
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)
1990
49
Evaluation of treatment for childhood medulloblastoma, with special reference to combination therapy with interferon and radiation. (2448687)
1987
50
The incidence of late endocrine dysfunction following irradiation for childhood medulloblastoma. (3721935)
1986

Variations for Childhood Medulloblastoma

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Expression for genes affiliated with Childhood Medulloblastoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Medulloblastoma

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Pathways for genes affiliated with Childhood Medulloblastoma

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 54R&D Systems
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Pathways related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MYC, TFAP2A
2
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.5ERBB3, MYC
39.5ERBB3, MYC

Compounds for genes affiliated with Childhood Medulloblastoma

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1hrgbeta1459.8ERBB3, MYC
215-deoxy-delta-12,14-prostaglandin j2459.7MYC, TFAP2A
3gemcitabine45 51 1111.6ERBB3, MYC
4phorbol459.5MYC, TFAP2A
5p00001459.4EPHX1, TFAP2A
6tcdd459.4EPHX1, TFAP2A
7cytosine45 2410.3SSTR2, TFAP2A
8phenobarbital45 29 51 1112.3MYC, EPHX1
9rapamycin459.3TFAP2A, MYC, ERBB3
10ornithine45 2410.2MYC, TFAP2A
11paraffin459.1ERBB3, SSTR2, MYC
12phosphotyrosine459.1ERBB3, SSTR2, TFAP2A
13forskolin45 51 1111.0TFAP2A, SSTR2, ERBB3
14progesterone45 29 61 24 1113.0TFAP2A, SSTR2, ERBB3
15cisplatin45 51 61 1111.9MYC, EPHX1, TFAP2A
16vegf458.7ERBB3, SSTR2, MYC, TFAP2A
17steroid458.5TFAP2A, EPHX1, ERBB3
18oligonucleotide458.5TFAP2A, EPHX1, MYC, ERBB3
19phosphatidylinositol458.5TFAP2A, EPHX1, MYC, ERBB3
20tamoxifen45 51 29 1111.4ERBB3, SSTR2, MYC, EPHX1
21estrogen457.9TFAP2A, EPHX1, MYC, SSTR2, ERBB3
22tyrosine457.9TFAP2A, EPHX1, MYC, SSTR2, ERBB3

GO Terms for genes affiliated with Childhood Medulloblastoma

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16Gene Ontology
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Biological processes related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.4ERBB3, TFAP2A
2negative regulation of cell proliferationGO:0082858.7BAP1, SSTR2, TFAP2A

Molecular functions related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.6ERBB3, BAP1, RAB18, SSTR2, MYC, TFAP2A

Products for genes affiliated with Childhood Medulloblastoma

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Sources for Childhood Medulloblastoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet