MCID: CHL018
MIFTS: 42

Childhood Medulloblastoma malady

Summaries for Childhood Medulloblastoma

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32MalaCards
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MalaCards: Childhood Medulloblastoma, also known as medulloblastoma, childhood, is related to medulloblastoma and adult medulloblastoma. An important gene associated with Childhood Medulloblastoma is PCDHGA10 (protocadherin gamma subfamily A, 10), and among its related pathways are ErbB signaling pathway and Akt Signaling Pathway . The compounds hrgbeta1 and phosphotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and thyroid, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Aliases & Classifications for Childhood Medulloblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 34MeSH
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Aliases & Descriptions:

childhood medulloblastoma 8 42 10
medulloblastoma, childhood 42 60
pediatric medulloblastoma 8
medulloblastoma childhood 44


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Disease Ontology8 DOID:3869
NCIt39 C3997
MeSH34 D008527

Related Diseases for Childhood Medulloblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Childhood Medulloblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.5TFAP2A, SSTR2, HRAS, MYC, PDGFRA, ERBB3
2adult medulloblastoma10.3
3primitive neuroectodermal tumor10.3
4pediatric ependymoma10.3
5brain medulloblastoma10.2
6thyroiditis10.2
7cerebritis10.0
8supratentorial primitive neuroectodermal tumor10.0
9atypical teratoid rhabdoid tumor10.0
10nevoid basal cell carcinoma syndrome10.0
11adult syndrome10.0
12hepatitis a10.0
13astrocytoma10.0
14basal cell carcinoma10.0
15brain cancer10.0
16hepatitis10.0
17hypothyroidism10.0
18spinal cancer10.0
19large cell medulloblastoma10.0PHF20, RAB18
20prolactinoma10.0SSTR2
21pituitary tumors10.0SSTR2, TFAP2A
22rhabdomyosarcoma10.0ERBB3, PDGFRA
23neurofibromatosis10.0PDGFRA, HRAS
24lung cancer10.0HRAS, MYC, ERBB3
25papillary carcinoma10.0HRAS, ERBB3, SSTR2
26non-small cell lung carcinoma10.0TFAP2A, MYC, HRAS, ERBB3
27pineoblastoma10.0OR4C12, PCDHGA10
28sarcoma10.0ERBB3, HRAS, SSTR2, PDGFRA
29prostate cancer10.0TFAP2A, MYC, HRAS, ERBB3, BMP7
30melanoma10.0PDGFRA, TFAP2A, SSTR2, MYC, HRAS, ERBB3
31colorectal cancer10.0MYC, ERBB3, HRAS, TFAP2A
32colon cancer10.0SSTR2, HRAS, TFAP2A, ERBB3, MYC
33malignant glioma10.0HRAS, SSTR2, TFAP2A, BMP7, PDGFRA, ERBB3
34embryonal cancer10.0PDGFRA, TFAP2A, BMP7
35glioblastoma multiforme10.0ERBB3, TFAP2A, MYC, HRAS, PDGFRA
36ovarian cancer10.0BMP7, ERBB3, HRAS, MYC, PDGFRA, SSTR2
37hepatocellular carcinoma10.0ERBB3, HRAS, SSTR2, TFAP2A, MYC, BMP7
38adenocarcinoma10.0ERBB3, MYC, TFAP2A, HRAS, SSTR2

Graphical network of the top 20 diseases related to Childhood Medulloblastoma:



Diseases related to childhood medulloblastoma

Clinical Features for Childhood Medulloblastoma

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Drugs & Therapeutics for Childhood Medulloblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Childhood Medulloblastoma

Drug clinical trials:

Search ClinicalTrials for Childhood Medulloblastoma

Search NIH Clinical Center for Childhood Medulloblastoma

Search CenterWatch for Childhood Medulloblastoma

Genetic Tests for Childhood Medulloblastoma

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Anatomical Context for Childhood Medulloblastoma

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32MalaCards
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MalaCards organs/tissues related to Childhood Medulloblastoma:

32
Brain, Bone, Thyroid, Testes, Parietal lobe

Animal Models for Childhood Medulloblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Childhood Medulloblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.1ERBB3, MYC, TFAP2A, BMP7, PDGFRA
2MP:00030129.8CACNG8, PDGFRA, PHF20, BAP1, MYC, HRAS
3MP:00053829.8PDGFRA, BMP7, TFAP2A, PHF20, MYC, HRAS
4MP:00053859.7PDGFRA, BMP7, TFAP2A, SSTR2, BAP1, MYC
5MP:00028739.7PDGFRA, BMP7, TFAP2A, MYC, H2AFY, HRAS
6MP:00053889.7PDGFRA, BMP7, TFAP2A, CROCC, HRAS, ERBB3
7MP:00053819.5PDGFRA, BMP7, TFAP2A, SSTR2, MYC, ERBB3
8MP:00053789.4CACNG8, PDGFRA, BMP7, TFAP2A, BAP1, MYC
9MP:00036319.4KLC1, CACNG8, PDGFRA, BMP7, TFAP2A, CROCC

Publications for Childhood Medulloblastoma

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50PubMed
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Articles related to Childhood Medulloblastoma:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma. (23292496)
2013
2
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. (22054800)
2012
3
Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study. (22661588)
2012
4
Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cells. (22980291)
2012
5
Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. (23095827)
2012
6
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. (21317922)
2011
7
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes. (21367970)
2011
8
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. (20921458)
2011
9
Progress in sequencing human cancer genomes: advancements in childhood medulloblastoma. (21900800)
2011
10
Intellectual impairment after treatment for medulloblastoma and astrocytoma in childhood: the Brazilian experience. (21941143)
2011
11
Risk-adapted chemotherapy in childhood medulloblastoma. (21554052)
2011
12
Childhood medulloblastoma. (21129995)
2011
13
Intact language skills and semantic processing speed following the use of fractionated cranial irradiation therapy for the treatment of childhood medulloblastoma: a 4-year follow-up study. (21207315)
2011
14
Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma. (22218450)
2011
15
Recurrence in childhood medulloblastoma. (21069427)
2011
16
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)
2010
17
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. (20978505)
2010
18
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. (20940197)
2010
19
A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report. (19149892)
2009
20
Examination of somatostatin receptor expression in recurrent childhood medulloblastomas]. (19068462)
2008
21
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. (17254356)
2007
22
Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. (17473196)
2007
23
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. (17601681)
2007
24
Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma. (18050040)
2007
25
Current treatment approaches to early childhood medulloblastoma. (16893348)
2006
26
Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma. (16997071)
2006
27
Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma. (15637691)
2005
28
White matter anisotropy in childhood medulloblastoma survivors: association with neurotoxicity risk factors. (16040920)
2005
29
Survivin expression in childhood medulloblastomas: a possible diagnostic and prognostic marker. (15646811)
2004
30
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
31
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. (14695141)
2003
32
Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival. (12729144)
2003
33
Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma. (11750844)
2002
34
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. (11391800)
2001
35
Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. (11483340)
2001
36
MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma. (11489822)
2001
37
Intracranial calcifications in childhood medulloblastoma: relation to nevoid basal cell carcinoma syndrome. (10782799)
2000
38
Childhood medulloblastoma in Denmark 1960-1984. A population-based retrospective study. (10066017)
1999
39
Correlation of the Health Utilities Index Mark 2 cognition scale and neuropsychological functioning among survivors of childhood medulloblastoma. (10679878)
1999
40
Childhood medulloblastoma: progress and future challenges. (10206522)
1999
41
Expression of the c-Myc protein in childhood medulloblastoma. (9482408)
1998
42
Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study. (9586884)
1998
43
Chemotherapy for Childhood Medulloblastoma and Primitive Neuroectodermal Tumors. (10388020)
1996
44
Radiotherapy and adjuvant chemotherapy for childhood medulloblastoma. The Royal Marsden Hospital experience. (7502224)
1995
45
Preirradiation chemotherapy including "eight drugs in 1 day" regimen and high-dose methotrexate in childhood medulloblastoma: results of the M7 French Cooperative Study. (7897523)
1995
46
Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. (7623725)
1995
47
Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. (8043463)
1994
48
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)
1990
49
Elevated c-myc expression in childhood medulloblastomas. (2198527)
1990
50
Chemotherapy of childhood medulloblastoma. (937282)
1976

Genetic Variations for Childhood Medulloblastoma

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Expression for genes affiliated with Childhood Medulloblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Medulloblastoma

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Pathways for genes affiliated with Childhood Medulloblastoma

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29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems, 59Tocris Bioscience, 51QIAGEN, 12EMD Millipore
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Pathways related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2MYC, HRAS, ERBB3
210.2ERBB3, MYC, PDGFRA
3
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10.1HRAS, MYC, PDGFRA
410.1HRAS, MYC, PDGFRA
510.1MYC, TFAP2A, BMP7
6
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10.0ERBB3, HRAS, MYC, PDGFRA
7
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10.0ERBB3, HRAS, MYC, PDGFRA
8
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10.0PDGFRA, MYC, HRAS, ERBB3
910.0PDGFRA, MYC, HRAS, ERBB3
10
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10.0CACNG8, PDGFRA, MYC, HRAS
11
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10.0ERBB3, HRAS, PDGFRA, CACNG8
12
Development Ligand-independent activation of ESR1 and ESR2
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10.0ERBB3, HRAS, PDGFRA, CACNG8
1310.0PDGFRA, HRAS, RAB11FIP3, ERBB3
14
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9.9PDGFRA, BMP7, MYC, HRAS, ERBB3
15
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9.9CACNG8, PDGFRA, BMP7, HRAS, ERBB3
16
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9.9CACNG8, PDGFRA, BMP7, HRAS, ERBB3
17
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9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3
18
Hide members
9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3
19
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9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3

Compounds for genes affiliated with Childhood Medulloblastoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1hrgbeta14410.3MYC, ERBB3
2phosphotyrosine4410.1PDGFRA, TFAP2A, SSTR2, HRAS, ERBB3
3paraffin4410.1PDGFRA, SSTR2, MYC, HRAS, ERBB3
4gemcitabine44 49 1112.1MYC, HRAS, ERBB3
5rapamycin4410.1ERBB3, HRAS, MYC, TFAP2A, BMP7, PDGFRA
6thymidine44 2411.0HRAS, MYC, SSTR2, BMP7, PDGFRA
7vegf449.9PDGFRA, BMP7, TFAP2A, SSTR2, MYC, HRAS
8progesterone44 59 28 11 2413.9ERBB3, HRAS, SSTR2, TFAP2A, BMP7
9estrogen449.9PDGFRA, BMP7, TFAP2A, SSTR2, MYC, HRAS
10oligonucleotide449.6ERBB3, HRAS, MYC, TFAP2A, PDGFRA
11calcium44 49 11 2412.6PDGFRA, BMP7, TFAP2A, SSTR2, PCDHGA10, HRAS

GO Terms for genes affiliated with Childhood Medulloblastoma

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16Gene Ontology
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Cellular components related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:03525310.2CROCC, KLC1

Biological processes related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:00828510.1HRAS, BAP1, SSTR2, TFAP2A
2negative regulation of neuron apoptotic processGO:04352410.0ERBB3, HRAS, NRBP2
3positive regulation of cell migrationGO:0303359.8PDGFRA, TFAP2A, HRAS

Molecular functions related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.8ERBB3, PDGFRA, BMP7, TFAP2A, PHF20, CROCC

Products for genes affiliated with Childhood Medulloblastoma

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Sources for Childhood Medulloblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet