MCID: CHL018
MIFTS: 42

Childhood Medulloblastoma malady

Rare diseases, Cancer diseases categories
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Summaries for Childhood Medulloblastoma

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MalaCards based summary: Childhood Medulloblastoma, also known as medulloblastoma, childhood, is related to medulloblastoma and large cell medulloblastoma. An important gene associated with Childhood Medulloblastoma is BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)), and among its related pathways are Neural Crest Differentiation and ErbB signaling pathway. The compounds hrgbeta1 and 15-deoxy-delta-12,14-prostaglandin j2 have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thyroid, and related mouse phenotypes are pigmentation and tumorigenesis.

Aliases & Classifications for Childhood Medulloblastoma

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Childhood Medulloblastoma, Aliases & Descriptions:

Name: Childhood Medulloblastoma 8 42 10
Medulloblastoma, Childhood 42 62
 
Pediatric Medulloblastoma 8
Medulloblastoma Childhood 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3869
MeSH34 D008527
NCIt39 C3997

Related Diseases for Childhood Medulloblastoma

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Graphical network of the top 20 diseases related to Childhood Medulloblastoma:



Diseases related to childhood medulloblastoma

Symptoms for Childhood Medulloblastoma

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Drugs & Therapeutics for Childhood Medulloblastoma

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Drug clinical trials:

Search ClinicalTrials for Childhood Medulloblastoma

Search NIH Clinical Center for Childhood Medulloblastoma

Genetic Tests for Childhood Medulloblastoma

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Anatomical Context for Childhood Medulloblastoma

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MalaCards organs/tissues related to Childhood Medulloblastoma:

32
Bone, Brain, Thyroid, Testes, Parietal lobe

Animal Models for Childhood Medulloblastoma or affiliated genes

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MGI Mouse Phenotypes related to Childhood Medulloblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9ERBB3, MYC, TFAP2A
2MP:00020068.4EPHX1, MYC, BAP1, ERBB3
3MP:00053818.4TFAP2A, MYC, SSTR2, ERBB3
4MP:00053808.3TFAP2A, MYC, BAP1, ERBB3
5MP:00053858.1ERBB3, BAP1, SSTR2, MYC, TFAP2A
6MP:00053767.7ERBB3, BAP1, SSTR2, MYC, EPHX1

Publications for Childhood Medulloblastoma

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Articles related to Childhood Medulloblastoma:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. (24276042)
2014
2
Ovarian function in survivors of childhood medulloblastoma: Impact of reduced dose craniospinal irradiation and high-dose chemotherapy with autologous stem cell rescue. (25346052)
2014
3
A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma. (23292496)
2013
4
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. (22054800)
2012
5
Chemotherapy dose-intensity and survival for childhood medulloblastoma. (22993333)
2012
6
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile. (22826514)
2012
7
Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cells. (22980291)
2012
8
Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. (23095827)
2012
9
Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study. (22994552)
2012
10
An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. (22389292)
2012
11
A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. (22153558)
2012
12
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. (21317922)
2011
13
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes. (21367970)
2011
14
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)
2010
15
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. (20978505)
2010
16
Childhood medulloblastoma: current status of biology and treatment. (20297854)
2010
17
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone-a critical review. (20689605)
2009
18
Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers. (19221477)
2009
19
Examination of somatostatin receptor expression in recurrent childhood medulloblastomas]. (19068462)
2008
20
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. (17254356)
2007
21
Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. (17473196)
2007
22
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. (17601681)
2007
23
The results of the treatment of childhood medulloblastoma with radiotherapy at Kaunas University of Medicine Hospital in 1994-2000. (16467610)
2006
24
Current treatment approaches to early childhood medulloblastoma. (16893348)
2006
25
Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. (15937648)
2005
26
Retrospective family study of childhood medulloblastoma. (15759260)
2005
27
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. (16258095)
2005
28
Prognostic significance of anaplasia and angiogenesis in childhood medulloblastoma: a pediatric oncology group study. (15462497)
2004
29
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
30
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. (14695141)
2003
31
Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. (11990307)
2002
32
Expression of C-myc and N-myc protein in adulthood and childhood medulloblastomas and prognostic analysis]. (12733375)
2001
33
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. (11391800)
2001
34
Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. (11483340)
2001
35
Ophthalmic complications of childhood medulloblastoma. (10611584)
2000
36
Childhood medulloblastoma in Denmark 1960-1984. A population-based retrospective study. (10066017)
1999
37
Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. (9893634)
1998
38
Expression of the c-Myc protein in childhood medulloblastoma. (9482408)
1998
39
Mitotic percentage index: a new prognostic factor for childhood medulloblastoma. (9274443)
1997
40
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. (9307291)
1997
41
Chemotherapy for Childhood Medulloblastoma and Primitive Neuroectodermal Tumors. (10388020)
1996
42
No preferential loss of one parental allele of chromosome 17p13.3 in childhood medulloblastoma. (7591234)
1995
43
Radiotherapy and adjuvant chemotherapy for childhood medulloblastoma. The Royal Marsden Hospital experience. (7502224)
1995
44
Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. (8043463)
1994
45
Partial transmission block radiotherapy technique for childhood medulloblastoma. (8428261)
1993
46
Childhood medulloblastoma. (1448667)
1992
47
DNA content and other prognostic features in childhood medulloblastoma. Proposal of a scoring system. (1739930)
1992
48
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)
1990
49
Evaluation of treatment for childhood medulloblastoma, with special reference to combination therapy with interferon and radiation. (2448687)
1987
50
The incidence of late endocrine dysfunction following irradiation for childhood medulloblastoma. (3721935)
1986

Variations for Childhood Medulloblastoma

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Expression for genes affiliated with Childhood Medulloblastoma

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Expression patterns in normal tissues for genes affiliated with Childhood Medulloblastoma

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Pathways for genes affiliated with Childhood Medulloblastoma

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Pathways related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MYC, TFAP2A
2
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5ERBB3, MYC
39.5ERBB3, MYC

Compounds for genes affiliated with Childhood Medulloblastoma

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Compounds related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1hrgbeta1449.8ERBB3, MYC
215-deoxy-delta-12,14-prostaglandin j2449.7MYC, TFAP2A
3gemcitabine44 50 1111.6ERBB3, MYC
4phorbol449.5MYC, TFAP2A
5p00001449.4EPHX1, TFAP2A
6tcdd449.4EPHX1, TFAP2A
7cytosine44 2410.3SSTR2, TFAP2A
8phenobarbital44 28 50 1112.3MYC, EPHX1
9rapamycin449.3TFAP2A, MYC, ERBB3
10ornithine44 2410.2MYC, TFAP2A
11paraffin449.1ERBB3, SSTR2, MYC
12phosphotyrosine449.1ERBB3, SSTR2, TFAP2A
13forskolin44 50 1111.0TFAP2A, SSTR2, ERBB3
14progesterone44 28 61 24 1113.0TFAP2A, SSTR2, ERBB3
15cisplatin44 50 61 1111.9MYC, EPHX1, TFAP2A
16vegf448.7ERBB3, SSTR2, MYC, TFAP2A
17steroid448.5TFAP2A, EPHX1, ERBB3
18oligonucleotide448.5TFAP2A, EPHX1, MYC, ERBB3
19phosphatidylinositol448.5TFAP2A, EPHX1, MYC, ERBB3
20tamoxifen44 50 28 1111.4ERBB3, SSTR2, MYC, EPHX1
21estrogen447.9TFAP2A, EPHX1, MYC, SSTR2, ERBB3
22tyrosine447.9TFAP2A, EPHX1, MYC, SSTR2, ERBB3

GO Terms for genes affiliated with Childhood Medulloblastoma

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Biological processes related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.4ERBB3, TFAP2A
2negative regulation of cell proliferationGO:0082858.7BAP1, SSTR2, TFAP2A

Molecular functions related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.6ERBB3, BAP1, RAB18, SSTR2, MYC, TFAP2A

Products for genes affiliated with Childhood Medulloblastoma

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Sources for Childhood Medulloblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet