MCID: CHL018
MIFTS: 47

Childhood Medulloblastoma

Categories: Rare diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Childhood Medulloblastoma

MalaCards integrated aliases for Childhood Medulloblastoma:

Name: Childhood Medulloblastoma 12 50 14
Medulloblastoma, Childhood 50 69
Pediatric Medulloblastoma 12
Medulloblastoma Childhood 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3869
MeSH 42 D008527
NCIt 47 C3997
UMLS 69 C0278510

Summaries for Childhood Medulloblastoma

MalaCards based summary : Childhood Medulloblastoma, also known as medulloblastoma, childhood, is related to medulloblastoma and pharynx carcinoma in situ, and has symptoms including headache, vomiting and gait ataxia. An important gene associated with Childhood Medulloblastoma is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Pathways in cancer and Development ERBB-family signaling. The drugs Cisplatin and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Childhood Medulloblastoma

Diseases related to Childhood Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
id Related Disease Score Top Affiliating Genes
1 medulloblastoma 10.6
2 pharynx carcinoma in situ 10.6 MYC MYCN
3 signet ring basal cell carcinoma 10.6 MYC PTCH1
4 juxtacortical osteosarcoma 10.5 MYC MYCN
5 vulvar keratoacanthoma-like carcinoma 10.4 MYC MYCN
6 melanotic medulloblastoma 10.3 MYC MYCN
7 homocystinuria due to defect in methylation cbl g 10.3 GLI2 PTCH1
8 camptocormism 10.3 GLI2 PTCH1
9 sporadic pheochromocytoma 10.3 GLI2 PTCH1
10 celosomia 10.3 GLI2 PTCH1
11 idiopathic syringomyelia 10.3 DDX3X MYC
12 small cell sarcoma 10.3 MYC MYCN PTCH1
13 laryngotracheoesophageal cleft type 2 10.2 GLI2 PTCH1
14 laryngotracheoesophageal cleft type 4 10.2 GLI2 PTCH1
15 large intestine lipoma 10.2 PTCH1 SUFU
16 isolated facial myokymia 10.2 GLI2 PTCH1
17 imperforate anus 10.0 GLI2 MYCN
18 oral antidiabetic drugs toxicity or dose selection 10.0 PTCH1 SUFU
19 functional colonic disease 9.9 GLI2 PTCH1 SUFU
20 pelizaeus-merzbacher disease in female carriers 9.9 GLI2 PTCH1 SUFU
21 basal cell nevus syndrome 9.9 GLI2 PTCH1 SUFU
22 orchitis 9.8 GLI2 PTCH1 SUFU
23 thyroiditis 9.7
24 macular dystrophy, patterned, 3 9.7 GLI2 PTCH1
25 hepatitis 9.6
26 hypothyroidism 9.6
27 atypical teratoid rhabdoid tumor 9.6
28 basal cell carcinoma 9.6
29 cerebritis 9.6
30 supratentorial primitive neuroectodermal tumor 9.6
31 ependymoma 9.6
32 radiation induced cancer 9.6
33 glioblastoma 3 9.1 ERBB4 MYC MYCN NTRK3 PTCH1 SUFU
34 skin hemangioma 9.0 GLI2 MYC MYCN NTRK3 PTCH1 SUFU
35 thrombophlebitis 6.2 DDX3X ERBB3 ERBB4 GLI2 MYC MYCN

Graphical network of the top 20 diseases related to Childhood Medulloblastoma:



Diseases related to Childhood Medulloblastoma

Symptoms & Phenotypes for Childhood Medulloblastoma

UMLS symptoms related to Childhood Medulloblastoma:


headache, vomiting, gait ataxia

MGI Mouse Phenotypes related to Childhood Medulloblastoma:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 ERBB3 ERBB4 GLI2 MYC MYCN NTRK3
2 cardiovascular system MP:0005385 10.15 DDX3X ERBB3 ERBB4 MYC MYCN NTRK3
3 growth/size/body region MP:0005378 10.15 DDX3X ERBB3 GLI2 MYC MYCN NTRK3
4 mortality/aging MP:0010768 10.13 DDX3X ERBB3 ERBB4 GLI2 MYC MYCN
5 embryo MP:0005380 10.11 DDX3X ERBB3 ERBB4 GLI2 MYC MYCN
6 nervous system MP:0003631 10.11 MYCN NTRK3 PRDM13 PTCH1 SH3GL1 SUFU
7 craniofacial MP:0005382 10.01 GLI2 MYC MYCN PTCH1 SUFU ERBB4
8 digestive/alimentary MP:0005381 10 ERBB3 GLI2 MYC MYCN PTCH1 SUFU
9 normal MP:0002873 9.96 DDX3X ERBB3 ERBB4 GLI2 MYC MYCN
10 integument MP:0010771 9.95 ERBB3 ERBB4 GLI2 MYC PTCH1 SUFU
11 muscle MP:0005369 9.95 PTCH1 DDX3X ERBB3 ERBB4 GLI2 MYC
12 limbs/digits/tail MP:0005371 9.85 SUFU GLI2 MYC MYCN PTCH1
13 no phenotypic analysis MP:0003012 9.8 GLI2 MYC MYCN NTRK3 PTCH1 SUFU
14 respiratory system MP:0005388 9.56 ERBB3 ERBB4 GLI2 MYCN NTRK3 PTCH1
15 pigmentation MP:0001186 9.46 ERBB3 MYC PTCH1 SUFU
16 vision/eye MP:0005391 9.1 NTRK3 PRDM13 PTCH1 SUFU GLI2 MYCN

Drugs & Therapeutics for Childhood Medulloblastoma

Drugs for Childhood Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Lomustine Approved Phase 3,Phase 2,Phase 1 13010-47-4 3950
3
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
4
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
7
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2 85622-93-1 5394
10 Thiotepa Approved Phase 3,Phase 2,Phase 1 52-24-4 5453
11
Levoleucovorin Approved Phase 3,Phase 2 68538-85-2
12
Mesna Approved Phase 3,Phase 2,Phase 1 3375-50-6 598
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
14
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
15
Ondansetron Approved Phase 3 99614-02-5 4595
16
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
17
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
18
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
20
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
21 Alkylating Agents Phase 3,Phase 2,Phase 1
22 Antimitotic Agents Phase 3,Phase 2,Phase 1
23 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
24 Antimetabolites Phase 3,Phase 2
25 Antimetabolites, Antineoplastic Phase 3,Phase 2
26 Antirheumatic Agents Phase 3,Phase 2,Phase 1
27 Dermatologic Agents Phase 3,Phase 2,Phase 1
28 Etoposide phosphate Phase 3,Phase 2,Phase 1
29 Folic Acid Antagonists Phase 3,Phase 2
30 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
31 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
33 Vitamin B Complex Phase 3,Phase 2
34 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
35 Protective Agents Phase 3,Phase 2,Phase 1
36 Liver Extracts Phase 3,Phase 2,Phase 1
37 Antidotes Phase 3,Phase 2,Phase 1
38 Calcium, Dietary Phase 3,Phase 2
39 Micronutrients Phase 3,Phase 2
40 Trace Elements Phase 3,Phase 2
41 Vitamins Phase 3
42 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
43 Anti-Infective Agents Phase 3,Phase 2,Phase 1
44 Antioxidants Phase 3,Phase 1,Phase 2
45 Antitubercular Agents Phase 3,Phase 1,Phase 2
46 Chelating Agents Phase 3,Phase 1,Phase 2
47 sodium thiosulfate Phase 3,Phase 1,Phase 2
48 Antiemetics Phase 3,Phase 1
49 Autonomic Agents Phase 3,Phase 1
50 BB 1101 Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 137)

id Name Status NCT ID Phase Drugs
1 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Unknown status NCT00053872 Phase 3 cisplatin;lomustine;vincristine sulfate
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
3 Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma Completed NCT00085735 Phase 3 Cisplatin;Cyclophosphamide;Lomustine;Vincristine Sulfate
4 Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma Completed NCT00336024 Phase 3 etoposide;cyclophosphamide;cisplatin;carboplatin;thiotepa;methotrexate;leucovorin calcium;vincristine sulfate
5 Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor Completed NCT00006461 Phase 3 cisplatin;cyclophosphamide;vincristine sulfate;etoposide
6 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Completed NCT00002875 Phase 3 cisplatin;cyclophosphamide;lomustine;mesna;vincristine sulfate
7 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
8 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
9 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3 Vincristine Sulfate;Carboplatin;Cisplatin;Cyclophosphamide;Isotretinoin
10 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
11 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
12 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
13 Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery Unknown status NCT00276666 Phase 2 cisplatin;lomustine;vincristine sulfate
14 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
15 High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood Unknown status NCT00180791 Phase 2 Etoposide, carboplatin, melphalan, cisplatin, thiotepa
16 Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma Completed NCT01239316 Phase 2 Vismodegib
17 Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-Metastatic Desmoplastic Medulloblastoma Completed NCT02017964 Phase 2 Vincristine Sulfate;Cyclophosphamide;Methotrexate;Etoposide;Carboplatin
18 Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma Completed NCT00003573 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
19 Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor Completed NCT00003211 Phase 2 amifostine trihydrate;cisplatin;cyclophosphamide;vincristine sulfate
20 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors Completed NCT00025077 Phase 2 carboplatin;cyclophosphamide;thiotepa
21 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Completed NCT00002594 Phase 2 cyclophosphamide;melphalan
22 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2 Oxaliplatin
23 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Completed NCT00381797 Phase 2 Irinotecan Hydrochloride
24 Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors Completed NCT00003203 Phase 2 carboplatin;cisplatin;cyclophosphamide;vincristine sulfate
25 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma Completed NCT00070525 Phase 2 tipifarnib
26 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors Completed NCT00095940 Phase 1, Phase 2 lapatinib ditosylate
27 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
28 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
29 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
30 Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment Completed NCT00005811 Phase 2 topotecan hydrochloride
31 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
32 Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors Completed NCT00003846 Phase 2 carboplatin;cyclophosphamide;thiotepa;vincristine sulfate
33 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
34 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
35 Lobradimil and Carboplatin in Treating Children With Brain Tumors Completed NCT00019422 Phase 2 carboplatin;lobradimil
36 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
37 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
38 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
39 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
40 Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors Completed NCT00002463 Phase 2 MOPP Regimen;Leucovorin Calcium;Mechlorethamine Hydrochloride;Methotrexate;Prednisone;Procarbazine Hydrochloride;Vincristine Sulfate
41 Docetaxel in Treating Children With Recurrent Solid Tumors Completed NCT00002825 Phase 2 docetaxel
42 Phenylacetate in Treating Children With Recurrent or Progressive Brain Tumors Completed NCT00003241 Phase 2 phenylacetate
43 Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2 Intra thecal methotrexate;topotecan;cyclophosphamide
44 WEE1 Inhibitor MK-1775 and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Recruiting NCT02095132 Phase 1, Phase 2 Irinotecan Hydrochloride;WEE1 Inhibitor AZD1775
45 A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma Recruiting NCT01878617 Phase 2 Cyclophosphamide;Cisplatin;Vincristine;Vismodegib;Pemetrexed;Gemcitabine
46 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
47 Pediatric MATCH: PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations Recruiting NCT03213678 Phase 2 PI3K/mTOR Inhibitor LY3023414
48 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
49 Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions Recruiting NCT03213704 Phase 2 Larotrectinib
50 Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) Recruiting NCT02624388 Phase 2 Genistein;Placebo

Search NIH Clinical Center for Childhood Medulloblastoma

Genetic Tests for Childhood Medulloblastoma

Anatomical Context for Childhood Medulloblastoma

MalaCards organs/tissues related to Childhood Medulloblastoma:

39
Brain, Bone, Bone Marrow, Testes, Spinal Cord, T Cells, Endothelial

Publications for Childhood Medulloblastoma

Articles related to Childhood Medulloblastoma:

(show top 50) (show all 127)
id Title Authors Year
1
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. ( 28545823 )
2017
2
Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia. ( 28717752 )
2017
3
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. ( 27040285 )
2016
4
The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma. ( 27785591 )
2016
5
Long-term safety of growth hormone replacement therapy after childhood medulloblastoma and PNET: it is time to set aside old concerns. ( 27770281 )
2016
6
Evolving molecular era of childhood medulloblastoma: time to revisit therapy. ( 26617331 )
2016
7
Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. ( 28039368 )
2016
8
Childhood medulloblastoma. ( 27375228 )
2016
9
Evidence of high mortality in long term survivors of childhood medulloblastoma. ( 25557108 )
2015
10
The use of 5-ALA to assist complete removal of residual non-enhancing part of childhood medulloblastoma: a case report. ( 26070965 )
2015
11
CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma. ( 26290144 )
2015
12
Ovarian function in survivors of childhood medulloblastoma: Impact of reduced dose craniospinal irradiation and high-dose chemotherapy with autologous stem cell rescue. ( 25346052 )
2014
13
Treatment developments and the unfolding of the quality of life discussion in childhood medulloblastoma: a review. ( 24569911 )
2014
14
The biologic era of childhood medulloblastoma and clues to novel therapies. ( 24754593 )
2014
15
Germline Mutations in SUFU Cause Gorlin Syndrome-Associated Childhood Medulloblastoma and Redefine the Risk Associated With PTCH1 Mutations. ( 25403219 )
2014
16
Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. ( 24276042 )
2014
17
NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. ( 24708907 )
2014
18
miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma. ( 23970061 )
2013
19
A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma. ( 23292496 )
2013
20
Treatment options for childhood medulloblastoma. ( 24069828 )
2013
21
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. ( 22054800 )
2012
22
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma. ( 22139329 )
2012
23
Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study. ( 22994552 )
2012
24
Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. ( 23095827 )
2012
25
Chemotherapy dose-intensity and survival for childhood medulloblastoma. ( 22993333 )
2012
26
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile. ( 22826514 )
2012
27
A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. ( 22153558 )
2012
28
An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. ( 22389292 )
2012
29
Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma. ( 22350379 )
2012
30
Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cells. ( 22980291 )
2012
31
Childhood medulloblastoma. ( 21129995 )
2011
32
Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma. ( 22218450 )
2011
33
Carboplatin and ototoxicity: hearing loss rates among survivors of childhood medulloblastoma. ( 20931205 )
2011
34
Intact language skills and semantic processing speed following the use of fractionated cranial irradiation therapy for the treatment of childhood medulloblastoma: a 4-year follow-up study. ( 21207315 )
2011
35
Integrated analysis of miRNA and mRNA expression in childhood medulloblastoma compared with neural stem cells. ( 21931624 )
2011
36
Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma. ( 20845476 )
2011
37
Progress in sequencing human cancer genomes: advancements in childhood medulloblastoma. ( 21900800 )
2011
38
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. ( 21317922 )
2011
39
Recurrence in childhood medulloblastoma. ( 21069427 )
2011
40
Expression of Oa8P-methylguanine-DNA methyltransferase in childhood medulloblastoma. ( 20820873 )
2011
41
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. ( 20921458 )
2011
42
Risk-adapted chemotherapy in childhood medulloblastoma. ( 21554052 )
2011
43
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes. ( 21367970 )
2011
44
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. ( 20940197 )
2010
45
Childhood medulloblastoma: current status of biology and treatment. ( 20297854 )
2010
46
A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma. ( 19806481 )
2010
47
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. ( 20053783 )
2010
48
Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease. ( 20652577 )
2010
49
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. ( 20978505 )
2010
50
A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report. ( 19149892 )
2009

Variations for Childhood Medulloblastoma

Expression for Childhood Medulloblastoma

Search GEO for disease gene expression data for Childhood Medulloblastoma.

Pathways for Childhood Medulloblastoma

Pathways related to Childhood Medulloblastoma according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1 12.22 GLI2 MYC PTCH1 SUFU
2
Show member pathways
12.18 ERBB3 ERBB4 MYC
3
Show member pathways
12.01 GLI2 PTCH1 SUFU
4
Show member pathways
11.95 ERBB3 ERBB4 MYC
5 11.84 GLI2 PTCH1 SUFU
6
Show member pathways
11.77 ERBB3 ERBB4 MYC NTRK3
7
Show member pathways
11.65 GLI2 PTCH1 SUFU
8 11.56 ERBB3 ERBB4 MYC PTCH1
9 11.09 GLI2 PTCH1
10
Show member pathways
10.91 GLI2 PTCH1
11 10.45 ERBB3 ERBB4 NTRK3
12 9.85 MYC MYCN

GO Terms for Childhood Medulloblastoma

Cellular components related to Childhood Medulloblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ciliary base GO:0097546 8.96 GLI2 SUFU
2 receptor complex GO:0043235 8.8 ERBB3 ERBB4 NTRK3

Biological processes related to Childhood Medulloblastoma according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 DDX3X ERBB4 GLI2 MYC
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.91 GLI2 MYC PRDM13 PTCH1 SUFU
3 positive regulation of transcription, DNA-templated GO:0045893 9.83 ERBB4 GLI2 MYC MYCN PTCH1
4 peptidyl-tyrosine phosphorylation GO:0018108 9.77 ERBB3 ERBB4 NTRK3
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.73 ERBB3 ERBB4 NTRK3
6 heart development GO:0007507 9.67 ERBB3 ERBB4 GLI2 NTRK3
7 positive regulation of cell proliferation GO:0008284 9.65 ERBB4 GLI2 MYC MYCN NTRK3
8 dorsal/ventral pattern formation GO:0009953 9.64 GLI2 PTCH1
9 negative regulation of osteoblast differentiation GO:0045668 9.64 PTCH1 SUFU
10 ERBB2 signaling pathway GO:0038128 9.63 ERBB3 ERBB4
11 mammary gland development GO:0030879 9.63 GLI2 PTCH1
12 regulation of cell motility GO:2000145 9.62 ERBB3 ERBB4
13 positive regulation of mesenchymal cell proliferation GO:0002053 9.62 MYC MYCN
14 branching morphogenesis of an epithelial tube GO:0048754 9.61 GLI2 MYCN
15 regulation of smoothened signaling pathway GO:0008589 9.59 GLI2 PTCH1
16 negative regulation of smoothened signaling pathway GO:0045879 9.58 PTCH1 SUFU
17 spinal cord motor neuron differentiation GO:0021522 9.57 GLI2 PTCH1
18 dorsal/ventral neural tube patterning GO:0021904 9.55 GLI2 PTCH1
19 negative regulation of ERBB signaling pathway GO:1901185 9.54 ERBB3 ERBB4
20 mammary gland epithelial cell differentiation GO:0060644 9.52 ERBB4 PTCH1
21 negative regulation of astrocyte differentiation GO:0048712 9.49 MYCN NTRK3
22 negative regulation of cell division GO:0051782 9.48 MYC PTCH1
23 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.46 GLI2 PTCH1
24 mammary gland duct morphogenesis GO:0060603 9.4 GLI2 PTCH1
25 spinal cord dorsal/ventral patterning GO:0021513 9.32 GLI2 SUFU
26 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.16 GLI2 SUFU
27 positive regulation of gene expression GO:0010628 9.02 DDX3X ERBB3 MYC MYCN NTRK3
28 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 8.96 GLI2 SUFU
29 regulation of transcription, DNA-templated GO:0006355 10.13 DDX3X ERBB4 GLI2 MYC MYCN PRDM13

Molecular functions related to Childhood Medulloblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.33 ERBB3 ERBB4 NTRK3
2 transcription factor binding GO:0008134 9.26 DDX3X GLI2 MYC SUFU
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 ERBB3 ERBB4 NTRK3

Sources for Childhood Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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37 KEGG
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60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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