MCID: CHL018
MIFTS: 42

Childhood Medulloblastoma malady

Summaries for Childhood Medulloblastoma

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MalaCards: Childhood Medulloblastoma, also known as medulloblastoma, childhood, is related to medulloblastoma and adult medulloblastoma. An important gene associated with Childhood Medulloblastoma is PCDHGA10 (protocadherin gamma subfamily A, 10), and among its related pathways are ErbB signaling pathway and Akt Signaling Pathway . The compounds hrgbeta1 and phosphotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and thyroid, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Aliases & Classifications for Childhood Medulloblastoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 34MeSH
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Aliases & Descriptions:

childhood medulloblastoma 8 42 10
medulloblastoma, childhood 42 60
pediatric medulloblastoma 8
medulloblastoma childhood 44


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Disease Ontology8 DOID:3869
NCIt39 C3997
MeSH34 D008527

Related Diseases for Childhood Medulloblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Childhood Medulloblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.5TFAP2A, SSTR2, HRAS, MYC, PDGFRA, ERBB3
2adult medulloblastoma10.3
3primitive neuroectodermal tumor10.3
4pediatric ependymoma10.3
5brain medulloblastoma10.2
6thyroiditis10.2
7cerebritis10.0
8supratentorial primitive neuroectodermal tumor10.0
9atypical teratoid rhabdoid tumor10.0
10nevoid basal cell carcinoma syndrome10.0
11adult syndrome10.0
12hepatitis a10.0
13astrocytoma10.0
14basal cell carcinoma10.0
15brain cancer10.0
16hepatitis10.0
17hypothyroidism10.0
18spinal cancer10.0
19large cell medulloblastoma10.0PHF20, RAB18
20prolactinoma10.0SSTR2
21pituitary tumors10.0SSTR2, TFAP2A
22rhabdomyosarcoma10.0ERBB3, PDGFRA
23neurofibromatosis10.0PDGFRA, HRAS
24lung cancer10.0HRAS, MYC, ERBB3
25papillary carcinoma10.0HRAS, ERBB3, SSTR2
26non-small cell lung carcinoma10.0TFAP2A, MYC, HRAS, ERBB3
27pineoblastoma10.0OR4C12, PCDHGA10
28sarcoma10.0ERBB3, HRAS, SSTR2, PDGFRA
29prostate cancer10.0TFAP2A, MYC, HRAS, ERBB3, BMP7
30melanoma10.0PDGFRA, TFAP2A, SSTR2, MYC, HRAS, ERBB3
31colorectal cancer10.0MYC, ERBB3, HRAS, TFAP2A
32colon cancer10.0SSTR2, HRAS, TFAP2A, ERBB3, MYC
33malignant glioma10.0HRAS, SSTR2, TFAP2A, BMP7, PDGFRA, ERBB3
34embryonal cancer10.0PDGFRA, TFAP2A, BMP7
35glioblastoma multiforme10.0ERBB3, TFAP2A, MYC, HRAS, PDGFRA
36ovarian cancer10.0BMP7, ERBB3, HRAS, MYC, PDGFRA, SSTR2
37hepatocellular carcinoma10.0ERBB3, HRAS, SSTR2, TFAP2A, MYC, BMP7
38adenocarcinoma10.0ERBB3, MYC, TFAP2A, HRAS, SSTR2

Graphical network of the top 20 diseases related to Childhood Medulloblastoma:



Diseases related to childhood medulloblastoma

Clinical Features for Childhood Medulloblastoma

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Drugs & Therapeutics for Childhood Medulloblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Childhood Medulloblastoma

Drug clinical trials:

Search ClinicalTrials for Childhood Medulloblastoma

Search NIH Clinical Center for Childhood Medulloblastoma

Search CenterWatch for Childhood Medulloblastoma

Genetic Tests for Childhood Medulloblastoma

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Anatomical Context for Childhood Medulloblastoma

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32MalaCards
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MalaCards organs/tissues related to Childhood Medulloblastoma:

32
Brain, Bone, Thyroid, Testes, Parietal lobe

Animal Models for Childhood Medulloblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Childhood Medulloblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.1TFAP2A, BMP7, ERBB3, MYC, PDGFRA
2MP:00030129.8HRAS, CACNG8, PDGFRA, BAP1, MYC, PHF20
3MP:00053829.8TFAP2A, BMP7, PDGFRA, PHF20, MYC, HRAS
4MP:00053859.7ERBB3, PDGFRA, BMP7, TFAP2A, SSTR2, BAP1
5MP:00028739.7MYC, ERBB3, HRAS, H2AFY, PDGFRA, BMP7
6MP:00053889.7PDGFRA, BMP7, TFAP2A, CROCC, HRAS, ERBB3
7MP:00053819.5MYC, PDGFRA, BMP7, TFAP2A, SSTR2, ERBB3
8MP:00053789.4CACNG8, HRAS, MYC, ERBB3, BAP1, KLC1
9MP:00036319.4ERBB3, HRAS, MYC, CROCC, TFAP2A, BMP7

Publications for Childhood Medulloblastoma

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50PubMed
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Articles related to Childhood Medulloblastoma:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. (24276042)
2014
2
Successful Treatment of Metastatic Relapse of Medulloblastoma in Childhood With Single Session Stereotactic Radiosurgery: A Report of 3 Cases. (23459380)
2013
3
Treatment options for childhood medulloblastoma. (24069828)
2013
4
miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma. (23970061)
2013
5
Chemotherapy dose-intensity and survival for childhood medulloblastoma. (22993333)
2012
6
An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. (22389292)
2012
7
A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. (22153558)
2012
8
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. (22184287)
2011
9
Inhibin B and anti-MA1llerian hormone as markers of gonadal function after treatment for medulloblastoma or posterior fossa ependymoma during childhood. (21168856)
2011
10
Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients. (22069434)
2011
11
Carboplatin and ototoxicity: hearing loss rates among survivors of childhood medulloblastoma. (20931205)
2011
12
Risk stratification of medulloblastoma: a paradigm for future childhood brain tumor management strategies. (21128022)
2011
13
Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma. (20845476)
2011
14
Childhood medulloblastoma: current status of biology and treatment. (20297854)
2010
15
Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers. (19221477)
2009
16
RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells. (19134217)
2009
17
Longterm treatment results of childhood medulloblastoma by craniospinal irradiation in supine position. (17203894)
2007
18
Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. (15937648)
2005
19
Retrospective family study of childhood medulloblastoma. (15759260)
2005
20
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. (15758008)
2005
21
Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. (16000568)
2005
22
Prognostic significance of anaplasia and angiogenesis in childhood medulloblastoma: a pediatric oncology group study. (15462497)
2004
23
Past, current and future protocols for combined modality therapy in childhood medulloblastoma. (12597352)
2003
24
Are childhood and adult medulloblastomas different? A comparative study of clinicopathological features, proliferation index and apoptotic index. (12222838)
2002
25
Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. (11990307)
2002
26
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. (11391800)
2001
27
Prognostic factors and secondary malignancies in childhood medulloblastoma. (11878577)
2001
28
Angiogenic profile of childhood primitive neuroectodermal brain tumours/medulloblastomas. (11597385)
2001
29
Ophthalmic complications of childhood medulloblastoma. (10611584)
2000
30
Vasoactive intestinal peptide (VIP) and VIP receptors: gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood. (10188714)
1999
31
Fas (APO-1, CD95) receptor expression and new options for immunotherapy in childhood medulloblastomas. (10652626)
1999
32
Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. (9893634)
1998
33
Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. (9737241)
1998
34
Mitotic percentage index: a new prognostic factor for childhood medulloblastoma. (9274443)
1997
35
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. (9307291)
1997
36
Childhood medulloblastoma in Ontario, 1977-1987: population-based results. (7494506)
1996
37
Carboplatin in childhood medulloblastoma/PNET: feasibility of an in vivo sensitivity test in an "up-front" study. (7838041)
1995
38
Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma. (7880726)
1995
39
Multidrug resistance gene expression in childhood medulloblastoma: correlation with clinical outcome and DNA ploidy in 29 patients. (8743996)
1995
40
Partial transmission block radiotherapy technique for childhood medulloblastoma. (8428261)
1993
41
DNA content--a prognostic factor in childhood medulloblastoma? (8260190)
1993
42
Is there a danger in delaying radiotherapy in childhood medulloblastoma? (8220953)
1993
43
Childhood medulloblastoma. (1448667)
1992
44
DNA content and other prognostic features in childhood medulloblastoma. Proposal of a scoring system. (1739930)
1992
45
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)
1990
46
Evaluation of treatment for childhood medulloblastoma, with special reference to combination therapy with interferon and radiation. (2448687)
1987
47
Childhood medulloblastoma presenting with hemorrhage. (6723428)
1984
48
Intracranial calcification in survivors of childhood medulloblastoma. (6830289)
1983
49
Intracranial calcification and childhood medulloblastoma. (6614987)
1983
50
Childhood medulloblastoma in Britain 1971-77: analysis of treatment and survival. (6652023)
1983

Genetic Variations for Childhood Medulloblastoma

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Expression for genes affiliated with Childhood Medulloblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood Medulloblastoma

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Pathways for genes affiliated with Childhood Medulloblastoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems, 59Tocris Bioscience, 51QIAGEN, 12EMD Millipore
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Pathways related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2MYC, HRAS, ERBB3
210.2ERBB3, MYC, PDGFRA
3
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10.1HRAS, MYC, PDGFRA
410.1HRAS, MYC, PDGFRA
510.1MYC, TFAP2A, BMP7
6
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10.0ERBB3, HRAS, MYC, PDGFRA
7
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10.0ERBB3, HRAS, MYC, PDGFRA
8
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10.0PDGFRA, MYC, HRAS, ERBB3
910.0PDGFRA, MYC, HRAS, ERBB3
10
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10.0CACNG8, PDGFRA, MYC, HRAS
11
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10.0ERBB3, HRAS, PDGFRA, CACNG8
12
Development Ligand-independent activation of ESR1 and ESR2
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10.0ERBB3, HRAS, PDGFRA, CACNG8
1310.0PDGFRA, HRAS, RAB11FIP3, ERBB3
14
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9.9PDGFRA, BMP7, MYC, HRAS, ERBB3
15
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9.9CACNG8, PDGFRA, BMP7, HRAS, ERBB3
16
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9.9CACNG8, PDGFRA, BMP7, HRAS, ERBB3
17
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9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3
18
Hide members
9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3
19
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9.8CACNG8, PDGFRA, BMP7, MYC, HRAS, ERBB3

Compounds for genes affiliated with Childhood Medulloblastoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1hrgbeta14410.3ERBB3, MYC
2phosphotyrosine4410.1HRAS, SSTR2, TFAP2A, PDGFRA, ERBB3
3paraffin4410.1MYC, SSTR2, ERBB3, PDGFRA, HRAS
4gemcitabine44 49 1112.1ERBB3, HRAS, MYC
5rapamycin4410.1PDGFRA, BMP7, TFAP2A, MYC, HRAS, ERBB3
6thymidine44 2411.0BMP7, MYC, SSTR2, PDGFRA, HRAS
7vegf449.9PDGFRA, BMP7, TFAP2A, SSTR2, MYC, HRAS
8progesterone44 59 28 11 2413.9SSTR2, TFAP2A, ERBB3, BMP7, HRAS
9estrogen449.9MYC, TFAP2A, ERBB3, HRAS, SSTR2, BMP7
10oligonucleotide449.6HRAS, MYC, TFAP2A, PDGFRA, ERBB3
11calcium44 49 11 2412.6ERBB3, SSTR2, HRAS, TFAP2A, BMP7, PDGFRA

GO Terms for genes affiliated with Childhood Medulloblastoma

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16Gene Ontology
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Cellular components related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:03525310.2CROCC, KLC1

Biological processes related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:00828510.1TFAP2A, SSTR2, BAP1, HRAS
2negative regulation of neuron apoptotic processGO:04352410.0NRBP2, HRAS, ERBB3
3positive regulation of cell migrationGO:0303359.8PDGFRA, TFAP2A, HRAS

Molecular functions related to Childhood Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.8ERBB3, PDGFRA, BMP7, TFAP2A, PHF20, CROCC

Products for genes affiliated with Childhood Medulloblastoma

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Sources for Childhood Medulloblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet