MCID: CHL078
MIFTS: 34

Childhood-Onset Schizophrenia malady

Categories: Rare diseases

Aliases & Classifications for Childhood-Onset Schizophrenia

Aliases & Descriptions for Childhood-Onset Schizophrenia:

Name: Childhood-Onset Schizophrenia 50 29
Schizophrenia, Childhood 69
Childhood Schizophrenia 50

Classifications:



Summaries for Childhood-Onset Schizophrenia

MalaCards based summary : Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and personality disorder. An important gene associated with Childhood-Onset Schizophrenia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Neuroscience and Biogenic Amine Synthesis. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe.

Related Diseases for Childhood-Onset Schizophrenia

Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 30.4 COMT DAOA GAD1 NRG1 PRL PRODH
2 personality disorder 29.6 COMT GAD1 NRG1
3 landau-kleffner syndrome 11.0
4 chromosome 16p11.2 deletion syndrome, 220kb 10.3 COMT PRODH
5 hypertrophic olivary degeneration 10.2 COMT PRODH
6 renpenning syndrome 10.2 COMT TPH1
7 unilateral hyperactive labyrinth 10.2 COMT GAD1
8 myopathy, distal, with early respiratory failure, autosomal dominant 10.2 COMT TPH1
9 deafness, autosomal recessive 29 10.2 GAD1 TPH1
10 multiple personality disorder 10.2 COMT TPH1
11 chronic eosinophilic pneumonia 10.2 COMT PRL
12 phaeohyphomycosis 10.2 GAD1 TPH1
13 testicular leydig cell tumor 10.1 COMT TPH1
14 haverhill fever 10.1 COMT PRL
15 carotid stenosis 10.1 COMT TPH1
16 cecal benign neoplasm 10.1 COMT TPH1
17 giant cell reparative granuloma 10.1 COMT NRG1
18 hepatitis d 10.1 COMT PRL TPH1
19 retinoblastoma 10.1 COMT PRL TPH1
20 keratosis 10.1 COMT TPH1
21 attention deficit-hyperactivity disorder 10.1
22 preeclampsia/eclampsia 5 10.1 COMT GAD1 TPH1
23 benign epilepsy with centrotemporal spikes 10.1 COMT DAOA TPH1
24 primary angle-closure glaucoma 10.0 COMT NRG1
25 rhinoscleroma 10.0 COMT NRG1 PRL
26 autism spectrum disorder 10.0
27 alzheimer disease 17 10.0 PRL TPH1
28 autistic disorder 9.9
29 mood disorder 9.7
30 cerebritis 9.7
31 mutism 9.7
32 neuronitis 9.7
33 hyperprolinemia 9.7
34 tardive dyskinesia 9.7
35 velocardiofacial syndrome 9.7
36 intellectual disability 9.7
37 early-onset schizophrenia 9.7
38 neutropenia 9.7
39 pervasive developmental disorder 9.7
40 schizotypal personality disorder 9.7
41 psychotic disorder 9.7
42 tic disorder 9.7
43 brain glioblastoma multiforme 9.6 COMT DAOA GAD1 NRG1 PRODH TPH1
44 chronic conjunctivitis 9.4 COMT DAOA GAD1 NRG1 PRL PRODH
45 chondrodysplasia lethal recessive 8.7 COMT DAOA GAD1 GPR153 NRG1 PRL

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to Childhood-Onset Schizophrenia

Symptoms & Phenotypes for Childhood-Onset Schizophrenia

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Drugs for Childhood-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4,Phase 2 113-45-1 4158
3
Clozapine Approved Phase 4 5786-21-0 2818
4
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
5
Cyproheptadine Approved Phase 4 129-03-3 2913
6
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
7
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
8 Neurotransmitter Agents Phase 4,Phase 2
9 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 2
11 Central Nervous System Stimulants Phase 4,Phase 2
12 Dopamine Agents Phase 4,Phase 2
13 Dopamine Uptake Inhibitors Phase 4,Phase 2
14 Antiemetics Phase 4
15 Antipsychotic Agents Phase 4,Phase 3
16 Autonomic Agents Phase 4,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 3
18 GABA Agents Phase 4
19 Gastrointestinal Agents Phase 4
20 Psychotropic Drugs Phase 4,Phase 3,Phase 2
21
Serotonin Phase 4,Phase 2 50-67-9 5202
22 Serotonin Agents Phase 4,Phase 2
23 Serotonin Antagonists Phase 4
24 Serotonin Uptake Inhibitors Phase 4,Phase 2
25 Tranquilizing Agents Phase 4,Phase 3
26 Anti-Allergic Agents Phase 4
27 Antipruritics Phase 4
28 Dermatologic Agents Phase 4
29 Histamine Antagonists Phase 4
30 Histamine H1 Antagonists Phase 4
31
Histamine Phosphate Phase 4 51-74-1 65513
32
Simvastatin Approved Phase 3 79902-63-9 54454
33 Antibodies Phase 3
34 gamma-Globulins Phase 3
35 Immunoglobulins Phase 3
36 Immunoglobulins, Intravenous Phase 3
37 Rho(D) Immune Globulin Phase 3
38 Anticholesteremic Agents Phase 3
39 Antimetabolites Phase 3
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
41 Hypolipidemic Agents Phase 3
42 Lipid Regulating Agents Phase 3
43
Amantadine Approved Phase 2 768-94-5 2130
44
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
45
Citalopram Approved Phase 2 59729-33-8 2771
46
Oxytocin Approved, Vet_approved Phase 1, Phase 2,Early Phase 1 50-56-6 439302 53477758
47
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
48 Analgesics Phase 2
49 Analgesics, Non-Narcotic Phase 2
50 Anti-Infective Agents Phase 2

Interventional clinical trials:

(show all 43)
id Name Status NCT ID Phase
1 Treating Drug-Resistant Childhood Schizophrenia Completed NCT00048828 Phase 4
2 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed NCT00001656 Phase 4
3 A Study of Combination Therapy in Children With ADHD Completed NCT01940978 Phase 4
4 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3
5 6-Year Follow-up of a Prevention Program for Bereaved Families Completed NCT01008189 Phase 3
6 15 Year Follow-up of New Beginnings Program for Divorced Families Completed NCT01407120 Phase 2, Phase 3
7 The Trauma Recovery and Empowerment Model for Treating Post-Traumatic Stress Disorder in Women Completed NCT00183716 Phase 3
8 Simvastatin Addition for Patients With Recent-onset Schizophrenia Recruiting NCT01999309 Phase 3
9 Amantadine Versus Ritalin in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) Unknown status NCT01099059 Phase 2
10 Carnitine as an Adjunct to Methylphenidate for the Treatment of Attention Deficit Hyperactivity Disorder Unknown status NCT01099072 Phase 2
11 Glycine to Treat Psychotic Disorders in Children Completed NCT00005658 Phase 2
12 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2
13 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2
14 A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood Dysregulation Recruiting NCT00794040 Phase 2
15 Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia Terminated NCT01712646 Phase 1, Phase 2
16 Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study Recruiting NCT01954680 Phase 1
17 Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia Terminated NCT00757497 Phase 1
18 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
19 Healthy Bodies, Healthy Kids Completed NCT01222494
20 Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes Completed NCT00108303
21 Healthy Brains & Behavior: Understanding and Treating Youth Aggression Completed NCT00842439
22 Oxcarbazepine Versus Placebo in Childhood Autism Completed NCT00467753
23 Psychosocial Training for Pediatric Health Care Providers Completed NCT00070876
24 A Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults Completed NCT01778478
25 Effect of Psychoeducation on Motivation to Change in Traumatized Alcoholics Completed NCT01323738
26 Brain Changes in Children and Adolescents With Behavioral Problems Completed NCT00104039
27 Detecting Risk of Suicide in a Pediatric Emergency Department Completed NCT00623493
28 Biomarkers of Cardiometabolic Risk in Children Treated With Antipsychotics: A Preliminary Study of Direct Measures Completed NCT00894738
29 Effectiveness of Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for Children With Post-traumatic Stress Disorder (TreatChildTrauma) Completed NCT01516827
30 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Recruiting NCT00001198
31 Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers Recruiting NCT00001246
32 Exploration and Characterization of Genetic and Phenotypic Profile of the"Schizotiste" Recruiting NCT02565524
33 A Randomized Controlled Trial of PCIT-ED for Preschool Depression Recruiting NCT02076425
34 Multi-center Imaging Genetics Studies in China Recruiting NCT02681822
35 Adult Study Oxytocin - Behavioral Recruiting NCT02567032 Early Phase 1
36 Adult Study Oxytocin - fMRI Recruiting NCT02566356 Early Phase 1
37 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Recruiting NCT02652988
38 Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria Recruiting NCT02415647
39 Screening for Childhood-Onset Psychotic Disorders Active, not recruiting NCT00049738
40 Adult Oxytocin Study Active, not recruiting NCT02577575 Early Phase 1
41 Oxytocin MEG Study Active, not recruiting NCT02568709 Early Phase 1
42 Antipsychotic Effects of Oxytocin Suspended NCT01621737
43 Effectiveness of Prolonged Exposure of PTSD in a Community Setting of PTSD Sufferers Withdrawn NCT00521768

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Genetic tests related to Childhood-Onset Schizophrenia:

id Genetic test Affiliating Genes
1 Childhood-Onset Schizophrenia 29

Anatomical Context for Childhood-Onset Schizophrenia

MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

39
Brain, Eye, Temporal Lobe, Testes, Cortex, Cerebellum

Publications for Childhood-Onset Schizophrenia

Articles related to Childhood-Onset Schizophrenia:

(show top 50) (show all 180)
id Title Authors Year
1
Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. ( 27566120 )
2016
2
Altered intra- and inter-network dynamics reflect symptom dimensions in childhood-onset schizophrenia. ( 26747855 )
2016
3
15q13.3 duplication in two patients with childhood-onset schizophrenia. ( 26968334 )
2016
4
DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 27829189 )
2016
5
A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia. ( 27626066 )
2016
6
Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. ( 26784704 )
2016
7
Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 25541139 )
2015
8
Childhood-onset schizophrenia case with 2.2A Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28. ( 25914809 )
2015
9
Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia. ( 26234702 )
2015
10
Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. ( 26493637 )
2015
11
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings. ( 25819937 )
2015
12
Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia. ( 25936396 )
2015
13
De novo variants in sporadic cases of childhood onset schizophrenia. ( 26508570 )
2015
14
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. ( 25019955 )
2014
15
Comparing Fractional Anisotropy in Patients With Childhood-Onset Schizophrenia, Their Healthy Siblings, and Normal Volunteers Through DTI. ( 25217482 )
2014
16
Common polygenic variation and risk for childhood-onset schizophrenia. ( 25510512 )
2014
17
Childhood-onset schizophrenia: what do we really know? ( 25750815 )
2014
18
Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers. ( 23782130 )
2013
19
Genetics of childhood-onset schizophrenia. ( 24012080 )
2013
20
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. ( 24391605 )
2013
21
Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. ( 23510445 )
2013
22
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. ( 21613381 )
2013
23
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. ( 23622854 )
2013
24
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. ( 23821644 )
2013
25
Evidence for Corticostriatal Dysfunction During Cognitive Skill Learning in Adolescent Siblings of Patients With Childhood-Onset Schizophrenia. ( 24162516 )
2013
26
Aspirin as an adjunctive treatment for childhood onset schizophrenia. ( 24138014 )
2013
27
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. ( 23682251 )
2013
28
Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings. ( 23154096 )
2013
29
High circulatory titer of platelet-associated autoantibodies in childhood onset schizophrenia and its diagnostic implications. ( 23881299 )
2013
30
Childhood onset schizophrenia and early onset schizophrenia spectrum disorders. ( 24012072 )
2013
31
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. ( 23770018 )
2013
32
Violence in childhood-onset schizophrenia. ( 25478126 )
2013
33
High rate of disease-related copy number variations in childhood onset schizophrenia. ( 23689535 )
2013
34
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 22945617 )
2012
35
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. ( 22675310 )
2012
36
A case report on the relationship between treatment-resistant childhood-onset schizophrenia and an abnormally enlarged cavum septum pellucidum combined with cavum vergae. ( 22613614 )
2012
37
17 years of treatment-resistant mutism in non-catatonic, childhood-onset schizophrenia: a rare case report. ( 22450644 )
2012
38
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
39
White matter integrity, language, and childhood onset schizophrenia. ( 22405729 )
2012
40
Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. ( 20955775 )
2011
41
Cerebellar development in childhood onset schizophrenia and non-psychotic siblings. ( 21803550 )
2011
42
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. ( 21620981 )
2011
43
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 21703497 )
2011
44
Childhood onset schizophrenia: high rate of visual hallucinations. ( 21703495 )
2011
45
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. ( 21245087 )
2011
46
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. ( 22032743 )
2011
47
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. ( 20479756 )
2011
48
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. ( 22147958 )
2010
49
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. ( 20347912 )
2010
50
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. ( 21031030 )
2010

Variations for Childhood-Onset Schizophrenia

Expression for Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for Childhood-Onset Schizophrenia

Pathways related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.64 COMT GAD1 TPH1
2
Show member pathways
10.14 COMT GAD1 TPH1

GO Terms for Childhood-Onset Schizophrenia

Cellular components related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.96 COMT NRG1
2 axon GO:0030424 8.8 COMT GAD1 NRG1

Biological processes related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 8.8 COMT GAD1 PRL

Sources for Childhood-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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