MCID: CHL078
MIFTS: 34

Childhood-Onset Schizophrenia malady

Rare diseases category

Summaries for Childhood-Onset Schizophrenia

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MalaCards based summary: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and attention deficit-hyperactivity disorder. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Nuclear signaling by ERBB4 and Biogenic Amine Synthesis. The compounds maoa and dihydrobiopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Childhood-Onset Schizophrenia

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Childhood-Onset Schizophrenia, Aliases & Descriptions:

Name: Childhood-Onset Schizophrenia 41
Schizophrenia, Childhood 60
 
Childhood Schizophrenia 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Childhood-Onset Schizophrenia

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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.3NOS1, COMT, PRL, DAOA
2attention deficit-hyperactivity disorder31.2COMT
3mood disorder29.3DAOA, TPH1, COMT, NRG1, GAD1, NOS1
4psychotic disorder28.7NOS1, DAOA, TPH1, PRL, COMT, NRG1
5generalized anxiety disorder10.4TPH1
6major depressive disorder and accelerated response to antidepressant drug treatment10.4TPH1
7autism spectrum disorder10.4
8autistic disorder10.3
9blindness10.3
10autoimmune polyendocrine syndrome type 110.2GAD1, TPH1
11neuroendocrine tumor10.2PRL
12substance dependence10.2COMT, TPH1
13obsessive-compulsive disorder10.2COMT, TPH1
14hyperphenylalaninemia10.2NOS1, TPH1
15landau-kleffner syndrome10.2
16panic disorder10.1TPH1, COMT
17neurotic disorder10.1NOS1, TPH1
18velocardiofacial syndrome10.1
19neutropenia10.1
20neuronitis10.1
21schizotypal personality disorder10.1
22mutism10.1
23cerebritis10.1
24personality disorder10.1
25pervasive developmental disorder10.1
26tic disorder10.1
27agenesis of the corpus callosum10.1
28hyperprolinemia10.1
29tardive dyskinesia10.1
30nicotine dependence, protection against10.1COMT, TPH1
31anxiety disorder10.0GAD1, COMT, TPH1
32alcohol dependence10.0TPH1, COMT, GAD1
33migraine10.0COMT, TPH1
34duchenne muscular dystrophy10.0NRG1, NOS1
35impotence10.0PRL, NOS1
36epilepsy syndrome9.9TPH1, GAD1, NOS1
37multiple sclerosis, disease progression, modifier of9.9GAD1, NRG1, COMT
38anorexia nervosa9.9TPH1, PRL, COMT
39hypoglycemia9.8GAD1, COMT, PRL
40prion disease9.8NRG1, NOS1
41ischemia9.8NRG1, GAD1, NOS1
42parkinson disease, late-onset9.7TPH1, COMT, GAD1, NOS1
43lung cancer9.7NOS1, NRG1, COMT
44melanoma9.7TPH1, COMT, NRG1, NOS1
45alzheimer disease9.5TPH1, COMT, NRG1, GAD1, NOS1
46bipolar disorder9.4DAOA, TPH1, COMT, NRG1, GAD1, NOS1
47breast cancer9.3PRL, COMT, NRG1, GAD1, NOS1

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Symptoms for Childhood-Onset Schizophrenia

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Drugs & Therapeutics for Childhood-Onset Schizophrenia

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Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

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Anatomical Context for Childhood-Onset Schizophrenia

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MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

31
Brain, Eye, Temporal lobe, Cortex, Cerebellum, Testes

Animal Models for Childhood-Onset Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5NOS1, GAD1, NRG1, TPH1
2MP:00053858.4NOS1, NRG1, COMT, TPH1
3MP:00053798.0NOS1, GAD1, NRG1, PRL
4MP:00053897.7PRL, COMT, NRG1, NOS1
5MP:00036317.5PRL, COMT, NRG1, GAD1, NOS1
6MP:00053867.3NOS1, GAD1, NRG1, COMT, PRL, TPH1
7MP:00053767.2TPH1, PRL, COMT, NRG1, GAD1, NOS1

Publications for Childhood-Onset Schizophrenia

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Articles related to Childhood-Onset Schizophrenia:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. (25019955)
2014
2
Childhood-onset schizophrenia: what do we really know? (25750815)
2014
3
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. (23682251)
2013
4
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. (23770018)
2013
5
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. (23622854)
2013
6
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. (24391605)
2013
7
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. (21613381)
2013
8
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. (22675310)
2012
9
White matter integrity, language, and childhood onset schizophrenia. (22405729)
2012
10
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. (22032743)
2011
11
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. (21703497)
2011
12
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. (20479756)
2011
13
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. (21245087)
2011
14
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. (21031030)
2010
15
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. (20347912)
2010
16
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. (22147958)
2010
17
The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent. (19302770)
2009
18
Childhood-onset schizophrenia: insights from neuroimaging studies. (20566189)
2008
19
Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. (17906336)
2008
20
Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder. (17879154)
2008
21
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
22
Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. (16818861)
2006
23
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia. (16763011)
2006
24
Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study. (15854790)
2005
25
Superior temporal gyrus differences in childhood-onset schizophrenia. (15653266)
2005
26
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. (14706940)
2004
27
Annotation: childhood-onset schizophrenia: clinical and treatment issues. (14982235)
2004
28
Olanzapine treatment in chronic drug-resistant childhood-onset schizophrenia: an open-label study. (14642019)
2003
29
Progressive loss of cerebellar volume in childhood-onset schizophrenia. (12505811)
2003
30
Differentiating childhood-onset schizophrenia from psychotic mood disorders. (11589532)
2001
31
Childhood-onset schizophrenia: research update. (11816313)
2001
32
Treatment of childhood-onset schizophrenia with olanzapine. (10933117)
2000
33
Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. (10742651)
2000
34
Obstetrical complications and childhood-onset schizophrenia. (10518182)
1999
35
The ESSEN study of childhood-onset schizophrenia: selected results. (10546980)
1999
36
Childhood-onset schizophrenia: a follow-up study. (10546978)
1999
37
Continuous-processing related ERPS in adult schizophrenia: continuity with childhood onset schizophrenia. (10349042)
1999
38
Why does postpsychotic IQ decline in childhood-onset schizophrenia? (10588420)
1999
39
Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. (10206241)
1999
40
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. (10401513)
1999
41
Childhood-onset schizophrenia associated with parkinsonism in a patient with a microdeletion of chromosome 22. (9787744)
1998
42
Attention deficits in childhood-onset schizophrenia: reaction time studies. (9505042)
1998
43
Pubertal development and onset of psychosis in childhood onset schizophrenia. (9172272)
1997
44
Cerebral glucose metabolism in childhood onset schizophrenia. (9437771)
1997
45
Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase. (9179938)
1995
46
Childhood-onset schizophrenia: the severity of premorbid course. (7592264)
1995
47
Annotation: childhood-onset schizophrenia. (7868633)
1994
48
Family-expressed emotion, childhood-onset depression, and childhood-onset schizophrenia spectrum disorders: is expressed emotion a nonspecific correlate of child psychopathology or a specific risk factor for depression? (8064026)
1994
49
Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. (2289947)
1990
50
The search for the psychobiological substrate of childhood onset schizophrenia. (3760409)
1986

Variations for Childhood-Onset Schizophrenia

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Expression for genes affiliated with Childhood-Onset Schizophrenia

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Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

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Pathways related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NRG1, PRL
2
Show member pathways
catecholamine biosynthesis36
9.1GAD1, COMT, TPH1
39.0TPH1, GAD1, NOS1
4
Show member pathways
8.5NOS1, GAD1, COMT, TPH1
5
Show member pathways
8.5NOS1, GAD1, COMT, TPH1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

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Compounds related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1maoa439.9TPH1, COMT
2dihydrobiopterin43 2410.8TPH1, NOS1
3fluvoxamine43 49 1211.8COMT, TPH1
4sepiapterin43 2410.8NOS1, TPH1
5pterin43 2410.8NOS1, TPH1
6l-amino acid439.7COMT, TPH1
7mdma439.6TPH1, PRL
85-hydroxytryptophan439.6TPH1, PRL
9tetrahydrobiopterin43 24 1211.6TPH1, NOS1
10fenfluramine43 28 1211.5PRL, TPH1
11mhpg439.5PRL, COMT
12s-nitroso-n-acetylpenicillamine439.4TPH1, NOS1
13pergolide43 28 1211.4COMT, PRL
14l-tryptophan49 28 43 24 1213.4PRL, TPH1
15pramipexole43 28 49 1212.4PRL, COMT
16cabergoline43 28 1211.4COMT, PRL
17methamphetamine43 49 1211.3TPH1, COMT, NOS1
18methionine439.3TPH1, COMT, GAD1
19mptp439.3NOS1, GAD1, COMT
20nicotine43 28 49 1212.3TPH1, COMT, NOS1
21valine439.3NOS1, COMT, TPH1
22apomorphine28 43 1211.2COMT, PRL
23valproate439.2GAD1, PRL
24carbidopa43 2810.2TPH1, PRL, COMT
25ascorbic acid43 2410.2NOS1, COMT, TPH1
26homovanillic acid43 2410.2TPH1, PRL, COMT
27paroxetine43 49 28 1212.2TPH1, PRL, COMT
28fluoxetine43 49 28 1212.0NOS1, PRL, TPH1
29proline439.0DAOA, COMT, NRG1, GAD1
30gnrh439.0GAD1, NRG1, PRL
31choline43 24 1210.9TPH1, COMT, GAD1, NOS1
32cocaine43 129.9NOS1, COMT, PRL
33gaba438.9NOS1, GAD1, NRG1, TPH1
34acetylcholine43 49 28 24 1212.9NOS1, GAD1, NRG1, TPH1
35bromocriptine43 28 1210.8COMT, PRL
36oxygen43 249.7TPH1, NRG1, GAD1, NOS1
37levodopa43 129.7GAD1, COMT, PRL, TPH1
38progesterone43 28 59 24 1212.7TPH1, PRL, NRG1, GAD1
39estradiol43 24 1210.6GAD1, COMT, PRL
405-hydroxytryptamine438.5NOS1, COMT, PRL, TPH1
41norepinephrine43 24 1210.5TPH1, PRL, COMT, NOS1
42arginine438.5TPH1, PRL, GAD1, NOS1
43clozapine43 28 49 1211.5PRL, COMT, GAD1, NOS1
44nmda43 289.4DAOA, COMT, NRG1, GAD1, NOS1
45tamoxifen43 49 28 1211.4PRL, COMT, NRG1, NOS1
46testosterone43 59 24 1211.4NOS1, NRG1, COMT, PRL
47cysteine438.3NOS1, GAD1, NRG1, COMT, TPH1
48glutamate438.0NOS1, GAD1, NRG1, COMT, TPH1, DAOA
49estrogen438.0TPH1, PRL, COMT, NRG1, NOS1
50dopamine43 28 24 1210.2NOS1, GAD1, NRG1, COMT, PRL, TPH1

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

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Biological processes related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00075659.1COMT, PRL
2neurotransmitter biosynthetic processGO:00421368.6NOS1, GAD1, COMT

Products for genes affiliated with Childhood-Onset Schizophrenia

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Sources for Childhood-Onset Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet