MCID: CHL078
MIFTS: 41

Childhood-Onset Schizophrenia malady

Rare diseases category

Summaries for Childhood-Onset Schizophrenia

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Wikipedia:64 Pediatric schizophrenia (also known as childhood schizophrenia, childhood-onset schizophrenia, and... more...

MalaCards based summary: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to attention deficit hyperactivity disorder and schizophrenia. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Nuclear signaling by ERBB4 and Biogenic Amine Synthesis. The compounds maoa and dihydrobiopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Childhood-Onset Schizophrenia

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Childhood-Onset Schizophrenia, Aliases & Descriptions:

Name: Childhood-Onset Schizophrenia 42 61
Schizophrenia, Childhood 61
 
Childhood Schizophrenia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Childhood-Onset Schizophrenia

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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.2COMT
2schizophrenia30.4DAOA, TPH1, PRL, COMT, NRG1, GAD1
3mood disorder29.3DAOA, TPH1, COMT, NRG1, GAD1, NOS1
4psychotic disorder28.7NOS1, DAOA, TPH1, PRL, COMT, NRG1
5generalized anxiety disorder10.4TPH1
6seasonal affective disorder10.4TPH1
7autism spectrum disorder10.4
8autistic disorder10.3
9blindness10.3
10autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2GAD1, TPH1
11neuroendocrine tumor10.2PRL
12substance dependence10.2COMT, TPH1
13obsessive-compulsive disorder10.2COMT, TPH1
14hyperphenylalaninemia10.2NOS1, TPH1
15landau-kleffner syndrome10.2
16bipolar disorder10.2NOS1, TPH1
17panic disorder10.1TPH1, COMT
18neutropenia10.1
19velocardiofacial syndrome10.1
20neuronitis10.1
21schizotypal personality disorder10.1
22mutism10.1
23cerebritis10.1
24personality disorder10.1
25pervasive developmental disorder10.1
26tic disorder10.1
27agenesis of the corpus callosum10.1
28hyperprolinemia10.1
29tardive dyskinesia10.1
30anxiety disorder10.0GAD1, COMT, TPH1
31migraine10.0COMT, TPH1
32duchenne muscular dystrophy10.0NRG1, NOS1
33impotence10.0PRL, NOS1
34epilepsy syndrome9.9TPH1, GAD1, NOS1
35multiple sclerosis9.9GAD1, NRG1, COMT
36anorexia nervosa9.9TPH1, PRL, COMT
37hypoglycemia9.8GAD1, COMT, PRL
38prion disease9.8NRG1, NOS1
39ischemia9.8NRG1, GAD1, NOS1
40parkinson's disease9.8TPH1, COMT, GAD1, NOS1
41non-small cell lung carcinoma9.7COMT, NRG1, NOS1
42lung cancer9.7NOS1, NRG1, COMT
43melanoma9.7TPH1, COMT, NRG1, NOS1
44schizoaffective disorder9.6NOS1, COMT, PRL, DAOA
45alzheimer's disease9.5TPH1, COMT, NRG1, GAD1, NOS1
46breast cancer9.3PRL, COMT, NRG1, GAD1, NOS1

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Symptoms for Childhood-Onset Schizophrenia

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Drugs & Therapeutics for Childhood-Onset Schizophrenia

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Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

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Anatomical Context for Childhood-Onset Schizophrenia

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MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

32
Brain, Eye, Temporal lobe, Cortex, Cerebellum, Testes

Animal Models for Childhood-Onset Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5NOS1, GAD1, NRG1, TPH1
2MP:00053858.4NOS1, NRG1, COMT, TPH1
3MP:00053798.0NOS1, GAD1, NRG1, PRL
4MP:00053897.7PRL, COMT, NRG1, NOS1
5MP:00036317.5PRL, COMT, NRG1, GAD1, NOS1
6MP:00053867.3NOS1, GAD1, NRG1, COMT, PRL, TPH1
7MP:00053767.2TPH1, PRL, COMT, NRG1, GAD1, NOS1

Publications for Childhood-Onset Schizophrenia

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Articles related to Childhood-Onset Schizophrenia:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. (25019955)
2014
2
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. (23682251)
2013
3
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. (23770018)
2013
4
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. (23622854)
2013
5
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. (24391605)
2013
6
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. (21613381)
2013
7
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. (22675310)
2012
8
White matter integrity, language, and childhood onset schizophrenia. (22405729)
2012
9
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. (22032743)
2011
10
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. (21703497)
2011
11
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. (20479756)
2011
12
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. (21245087)
2011
13
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. (21031030)
2010
14
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. (20347912)
2010
15
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. (22147958)
2010
16
The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent. (19302770)
2009
17
Childhood-onset schizophrenia: insights from neuroimaging studies. (20566189)
2008
18
Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. (17906336)
2008
19
Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder. (17879154)
2008
20
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
21
Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. (16818861)
2006
22
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia. (16763011)
2006
23
Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study. (15854790)
2005
24
Superior temporal gyrus differences in childhood-onset schizophrenia. (15653266)
2005
25
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. (14706940)
2004
26
Annotation: childhood-onset schizophrenia: clinical and treatment issues. (14982235)
2004
27
Olanzapine treatment in chronic drug-resistant childhood-onset schizophrenia: an open-label study. (14642019)
2003
28
Progressive loss of cerebellar volume in childhood-onset schizophrenia. (12505811)
2003
29
Differentiating childhood-onset schizophrenia from psychotic mood disorders. (11589532)
2001
30
Childhood-onset schizophrenia: research update. (11816313)
2001
31
Treatment of childhood-onset schizophrenia with olanzapine. (10933117)
2000
32
Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. (10742651)
2000
33
Obstetrical complications and childhood-onset schizophrenia. (10518182)
1999
34
The ESSEN study of childhood-onset schizophrenia: selected results. (10546980)
1999
35
Childhood-onset schizophrenia: a follow-up study. (10546978)
1999
36
Continuous-processing related ERPS in adult schizophrenia: continuity with childhood onset schizophrenia. (10349042)
1999
37
Why does postpsychotic IQ decline in childhood-onset schizophrenia? (10588420)
1999
38
Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. (10206241)
1999
39
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. (10401513)
1999
40
Detection of polyglutamine expansion in a new acidic protein: a candidate for childhood onset schizophrenia? (10089010)
1999
41
Childhood-onset schizophrenia associated with parkinsonism in a patient with a microdeletion of chromosome 22. (9787744)
1998
42
Attention deficits in childhood-onset schizophrenia: reaction time studies. (9505042)
1998
43
Pubertal development and onset of psychosis in childhood onset schizophrenia. (9172272)
1997
44
Cerebral glucose metabolism in childhood onset schizophrenia. (9437771)
1997
45
Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase. (9179938)
1995
46
Childhood-onset schizophrenia: the severity of premorbid course. (7592264)
1995
47
Annotation: childhood-onset schizophrenia. (7868633)
1994
48
Family-expressed emotion, childhood-onset depression, and childhood-onset schizophrenia spectrum disorders: is expressed emotion a nonspecific correlate of child psychopathology or a specific risk factor for depression? (8064026)
1994
49
Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. (2289947)
1990
50
The search for the psychobiological substrate of childhood onset schizophrenia. (3760409)
1986

Variations for Childhood-Onset Schizophrenia

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Expression for genes affiliated with Childhood-Onset Schizophrenia

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Expression patterns in normal tissues for genes affiliated with Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

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Pathways related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NRG1, PRL
2
Show member pathways
catecholamine biosynthesis37
9.1GAD1, COMT, TPH1
39.0TPH1, GAD1, NOS1
4
Show member pathways
8.5NOS1, GAD1, COMT, TPH1
5
Show member pathways
8.5NOS1, GAD1, COMT, TPH1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

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Compounds related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1maoa449.9TPH1, COMT
2dihydrobiopterin44 2510.8TPH1, NOS1
3fluvoxamine44 50 1211.8COMT, TPH1
4sepiapterin44 2510.8NOS1, TPH1
5pterin44 2510.8NOS1, TPH1
6l-amino acid449.7COMT, TPH1
7mdma449.6TPH1, PRL
85-hydroxytryptophan449.6TPH1, PRL
9tetrahydrobiopterin44 25 1211.6TPH1, NOS1
10fenfluramine44 29 1211.5PRL, TPH1
11mhpg449.5PRL, COMT
12s-nitroso-n-acetylpenicillamine449.4TPH1, NOS1
13pergolide44 29 1211.4COMT, PRL
14l-tryptophan50 29 44 25 1213.4PRL, TPH1
15pramipexole44 29 50 1212.4PRL, COMT
16cabergoline44 29 1211.4COMT, PRL
17methamphetamine44 50 1211.3TPH1, COMT, NOS1
18methionine449.3TPH1, COMT, GAD1
19mptp449.3NOS1, GAD1, COMT
20nicotine44 29 50 1212.3TPH1, COMT, NOS1
21valine449.3NOS1, COMT, TPH1
22apomorphine29 44 1211.2COMT, PRL
23valproate449.2GAD1, PRL
24carbidopa44 2910.2TPH1, PRL, COMT
25ascorbic acid44 2510.2NOS1, COMT, TPH1
26homovanillic acid44 2510.2TPH1, PRL, COMT
27paroxetine44 50 29 1212.2TPH1, PRL, COMT
28fluoxetine44 50 29 1212.0NOS1, PRL, TPH1
29proline449.0DAOA, COMT, NRG1, GAD1
30gnrh449.0GAD1, NRG1, PRL
31choline44 25 1210.9TPH1, COMT, GAD1, NOS1
32cocaine44 129.9NOS1, COMT, PRL
33gaba448.9NOS1, GAD1, NRG1, TPH1
34acetylcholine44 50 29 25 1212.9NOS1, GAD1, NRG1, TPH1
35bromocriptine44 29 1210.8COMT, PRL
36oxygen44 259.7TPH1, NRG1, GAD1, NOS1
37levodopa44 129.7GAD1, COMT, PRL, TPH1
38progesterone44 29 60 25 1212.7TPH1, PRL, NRG1, GAD1
39estradiol44 25 1210.6GAD1, COMT, PRL
405-hydroxytryptamine448.5NOS1, COMT, PRL, TPH1
41norepinephrine44 25 1210.5TPH1, PRL, COMT, NOS1
42arginine448.5TPH1, PRL, GAD1, NOS1
43clozapine44 29 50 1211.5PRL, COMT, GAD1, NOS1
44nmda44 299.4DAOA, COMT, NRG1, GAD1, NOS1
45tamoxifen44 50 29 1211.4PRL, COMT, NRG1, NOS1
46testosterone44 60 25 1211.4NOS1, NRG1, COMT, PRL
47cysteine448.3NOS1, GAD1, NRG1, COMT, TPH1
48glutamate448.0NOS1, GAD1, NRG1, COMT, TPH1, DAOA
49estrogen448.0TPH1, PRL, COMT, NRG1, NOS1
50dopamine44 29 25 1210.2NOS1, GAD1, NRG1, COMT, PRL, TPH1

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

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Biological processes related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.1COMT, PRL
2neurotransmitter biosynthetic processGO:0421368.6NOS1, GAD1, COMT

Products for genes affiliated with Childhood-Onset Schizophrenia

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Sources for Childhood-Onset Schizophrenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet