MCID: CHL078
MIFTS: 41

Childhood-Onset Schizophrenia malady

Rare diseases category

Summaries for Childhood-Onset Schizophrenia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pediatric schizophrenia (also known as childhood schizophrenia, childhood-onset schizophrenia, and... more...

MalaCards: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and attention deficit hyperactivity disorder. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Nuclear signaling by ERBB4 and Biogenic Amine Synthesis. The compounds maoa and dihydrobiopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Childhood-Onset Schizophrenia

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

childhood-onset schizophrenia 44
schizophrenia, childhood 63
childhood schizophrenia 44


Related Diseases for Childhood-Onset Schizophrenia

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18GeneCards, 19GeneDecks
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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.5DAOA, TPH1, PRL, NOS1, GAD1, COMT
2attention deficit hyperactivity disorder30.8COMT
3mood disorder30.0COMT, TPH1, NRG1, DAOA, NOS1, GAD1
4psychotic disorder29.8NOS1, PRL, TPH1, DAOA, NRG1, COMT
5autism spectrum disorder10.4
6autistic disorder10.3
7blindness10.3
8landau-kleffner syndrome10.1
9neuronitis10.1
10schizotypal personality disorder10.1
11mutism10.1
12velocardiofacial syndrome10.1
13cerebritis10.1
14intellectual disability10.1
15neutropenia10.1
16personality disorder10.1
17pervasive developmental disorder10.1
18tic disorder10.1
19hyperprolinemia10.1
20tardive dyskinesia10.1
21early-onset schizophrenia10.1
22generalized anxiety disorder10.1TPH1
23seasonal affective disorder10.1TPH1
24autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1GAD1, TPH1
25neuroendocrine tumor10.0PRL
26substance dependence10.0TPH1, COMT
27obsessive-compulsive disorder10.0TPH1, COMT
28hyperphenylalaninemia10.0NOS1, TPH1
29panic disorder10.0COMT, TPH1
30bipolar disorder10.0TPH1, NOS1
31migraine10.0TPH1, COMT
32anxiety disorder10.0COMT, GAD1, TPH1
33duchenne muscular dystrophy10.0NRG1, NOS1
34encephalomyelitis10.0GAD1, NRG1
35impotence10.0PRL, NOS1
36epilepsy syndrome10.0TPH1, NOS1, GAD1
37multiple sclerosis10.0COMT, GAD1, NRG1
38anorexia nervosa10.0COMT, TPH1, PRL
39hypoglycemia10.0PRL, GAD1, COMT
40prion disease10.0NRG1, NOS1
41ischemia10.0NRG1, NOS1, GAD1
42non-small cell lung carcinoma9.9COMT, NRG1, NOS1
43parkinson's disease9.9GAD1, NOS1, COMT, TPH1
44lung cancer9.9NOS1, COMT, NRG1
45melanoma9.9NRG1, COMT, TPH1, NOS1
46schizoaffective disorder9.9DAOA, PRL, COMT, NOS1
47alzheimer's disease9.9NOS1, NRG1, COMT, TPH1, GAD1
48breast cancer9.8NRG1, COMT, GAD1, NOS1, PRL

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Symptoms for Childhood-Onset Schizophrenia

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Drugs & Therapeutics for Childhood-Onset Schizophrenia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood-Onset Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Search CenterWatch for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

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Anatomical Context for Childhood-Onset Schizophrenia

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34MalaCards
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MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

34
Brain, Eye, Temporal lobe, Testes, Cortex, Cerebellum

Animal Models for Childhood-Onset Schizophrenia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5TPH1, NRG1, NOS1, GAD1
2MP:00053858.4NOS1, NRG1, COMT, TPH1
3MP:00053798.0NOS1, GAD1, NRG1, PRL
4MP:00053897.7PRL, COMT, NRG1, NOS1
5MP:00036317.5NOS1, GAD1, NRG1, COMT, PRL
6MP:00053867.3NOS1, GAD1, NRG1, COMT, PRL, TPH1
7MP:00053767.2GAD1, NRG1, COMT, TPH1, NOS1, PRL

Publications for Childhood-Onset Schizophrenia

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Sources:
53PubMed
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Articles related to Childhood-Onset Schizophrenia:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. (23682251)
2013
2
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. (23770018)
2013
3
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. (23622854)
2013
4
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. (24391605)
2013
5
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. (21613381)
2013
6
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. (22675310)
2012
7
White matter integrity, language, and childhood onset schizophrenia. (22405729)
2012
8
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. (22032743)
2011
9
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. (21703497)
2011
10
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. (20479756)
2011
11
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. (21245087)
2011
12
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. (21031030)
2010
13
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. (20347912)
2010
14
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. (22147958)
2010
15
The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent. (19302770)
2009
16
Childhood-onset schizophrenia: insights from neuroimaging studies. (20566189)
2008
17
Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. (17906336)
2008
18
Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder. (17879154)
2008
19
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
20
Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. (16818861)
2006
21
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia. (16763011)
2006
22
Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study. (15854790)
2005
23
Superior temporal gyrus differences in childhood-onset schizophrenia. (15653266)
2005
24
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. (14706940)
2004
25
Annotation: childhood-onset schizophrenia: clinical and treatment issues. (14982235)
2004
26
Olanzapine treatment in chronic drug-resistant childhood-onset schizophrenia: an open-label study. (14642019)
2003
27
Progressive loss of cerebellar volume in childhood-onset schizophrenia. (12505811)
2003
28
Differentiating childhood-onset schizophrenia from psychotic mood disorders. (11589532)
2001
29
Childhood-onset schizophrenia: research update. (11816313)
2001
30
Treatment of childhood-onset schizophrenia with olanzapine. (10933117)
2000
31
Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. (10742651)
2000
32
Obstetrical complications and childhood-onset schizophrenia. (10518182)
1999
33
The ESSEN study of childhood-onset schizophrenia: selected results. (10546980)
1999
34
Childhood-onset schizophrenia: a follow-up study. (10546978)
1999
35
Continuous-processing related ERPS in adult schizophrenia: continuity with childhood onset schizophrenia. (10349042)
1999
36
Why does postpsychotic IQ decline in childhood-onset schizophrenia? (10588420)
1999
37
Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. (10206241)
1999
38
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. (10401513)
1999
39
Detection of polyglutamine expansion in a new acidic protein: a candidate for childhood onset schizophrenia? (10089010)
1999
40
Childhood-onset schizophrenia associated with parkinsonism in a patient with a microdeletion of chromosome 22. (9787744)
1998
41
Attention deficits in childhood-onset schizophrenia: reaction time studies. (9505042)
1998
42
Pubertal development and onset of psychosis in childhood onset schizophrenia. (9172272)
1997
43
Cerebral glucose metabolism in childhood onset schizophrenia. (9437771)
1997
44
Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. (8931918)
1996
45
Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase. (9179938)
1995
46
Childhood-onset schizophrenia: the severity of premorbid course. (7592264)
1995
47
Annotation: childhood-onset schizophrenia. (7868633)
1994
48
Family-expressed emotion, childhood-onset depression, and childhood-onset schizophrenia spectrum disorders: is expressed emotion a nonspecific correlate of child psychopathology or a specific risk factor for depression? (8064026)
1994
49
Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. (2289947)
1990
50
The search for the psychobiological substrate of childhood onset schizophrenia. (3760409)
1986

Variations for Childhood-Onset Schizophrenia

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Expression for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG
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Pathways related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NRG1, PRL
2
Show member pathways
catecholamine biosynthesis39
9.1COMT, TPH1, GAD1
39.0NOS1, TPH1, GAD1
4
Show member pathways
8.5NOS1, GAD1, COMT, TPH1
5
Show member pathways
8.5NOS1, GAD1, COMT, TPH1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1maoa469.9COMT, TPH1
2dihydrobiopterin46 2510.8NOS1, TPH1
3fluvoxamine46 52 1211.8TPH1, COMT
4sepiapterin46 2510.8NOS1, TPH1
5pterin46 2510.8NOS1, TPH1
6l-amino acid469.7COMT, TPH1
7mdma469.6PRL, TPH1
85-hydroxytryptophan469.6TPH1, PRL
9tetrahydrobiopterin46 25 1211.6NOS1, TPH1
10fenfluramine46 30 1211.5TPH1, PRL
11mhpg469.5PRL, COMT
12s-nitroso-n-acetylpenicillamine469.4TPH1, NOS1
13pergolide46 30 1211.4PRL, COMT
14l-tryptophan52 30 46 25 1213.4PRL, TPH1
15pramipexole46 30 52 1212.4PRL, COMT
16cabergoline46 30 1211.4COMT, PRL
17methamphetamine46 52 1211.3NOS1, COMT, TPH1
18mptp469.3NOS1, COMT, GAD1
19methionine469.3GAD1, TPH1, COMT
20nicotine46 30 52 1212.3TPH1, NOS1, COMT
21valine469.3NOS1, TPH1, COMT
22apomorphine30 46 1211.2PRL, COMT
23valproate469.2GAD1, PRL
24carbidopa46 3010.2PRL, TPH1, COMT
25ascorbic acid46 2510.2COMT, TPH1, NOS1
26homovanillic acid46 2510.2TPH1, PRL, COMT
27paroxetine46 52 30 1212.2COMT, TPH1, PRL
28fluoxetine46 52 30 1212.0PRL, NOS1, TPH1
29proline469.0DAOA, COMT, NRG1, GAD1
30gnrh469.0GAD1, NRG1, PRL
31choline46 25 1210.9TPH1, COMT, GAD1, NOS1
32cocaine46 129.9PRL, COMT, NOS1
33gaba468.9NOS1, GAD1, NRG1, TPH1
34acetylcholine46 52 30 25 1212.9NOS1, TPH1, GAD1, NRG1
35bromocriptine46 30 1210.8COMT, PRL
36oxygen46 259.7NRG1, NOS1, GAD1, TPH1
37levodopa46 129.7GAD1, COMT, PRL, TPH1
38progesterone46 30 62 25 1212.7NRG1, GAD1, TPH1, PRL
39estradiol46 25 1210.6GAD1, COMT, PRL
405-hydroxytryptamine468.5TPH1, NOS1, COMT, PRL
41norepinephrine46 25 1210.5TPH1, NOS1, COMT, PRL
42arginine468.5NOS1, PRL, TPH1, GAD1
43clozapine46 30 52 1211.5NOS1, GAD1, COMT, PRL
44nmda46 309.4COMT, NRG1, DAOA, NOS1, GAD1
45tamoxifen46 52 30 1211.4NOS1, NRG1, COMT, PRL
46testosterone46 62 25 1211.4NOS1, COMT, PRL, NRG1
47cysteine468.3COMT, GAD1, NOS1, TPH1, NRG1
48glutamate468.0GAD1, NOS1, NRG1, COMT, TPH1, DAOA
49estrogen468.0NOS1, NRG1, COMT, TPH1, PRL
50dopamine46 30 25 1210.2GAD1, NRG1, COMT, PRL, TPH1, DAOA

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

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17Gene Ontology
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Biological processes related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.1COMT, PRL
2neurotransmitter biosynthetic processGO:0421368.6NOS1, GAD1, COMT

Products for genes affiliated with Childhood-Onset Schizophrenia

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Sources for Childhood-Onset Schizophrenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet