MCID: CHL078
MIFTS: 27

Childhood-Onset Schizophrenia malady

Summaries for Childhood-Onset Schizophrenia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pediatric schizophrenia (also known as childhood schizophrenia, childhood-onset schizophrenia, and... more...

MalaCards: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and attention deficit hyperactivity disorder. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Prolactin receptor signaling and Regulation of thyroid hormone activity. The compounds pergolide and dihydrobiopterin have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Childhood-Onset Schizophrenia

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

childhood-onset schizophrenia 42
schizophrenia, childhood 60
childhood schizophrenia 42


Related Diseases for Childhood-Onset Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.7NRG1, DAOA, TPH1, NOS1, PRODH, COMT
2attention deficit hyperactivity disorder30.6TPH1, COMT
3mood disorder30.3NRG1, DAOA, NOS1, TPH1, GAD1, COMT
4psychotic disorder30.3PRL, TPH1, NOS1, DAOA, NRG1, PRODH
5intellectual disability30.1UPF3B
6velocardiofacial syndrome30.1PRODH, COMT
7autism spectrum disorder10.3
8autistic disorder10.2
9landau-kleffner syndrome10.1
10cerebritis10.1
11neuronitis10.1
12schizotypal personality disorder10.1
13mutism10.1
14neutropenia10.1
15personality disorder10.1
16pervasive developmental disorder10.1
17tic disorder10.1
18borderline personality disorder10.0TPH1
19hyperprolinemia10.0PRODH
20irritable bowel syndrome10.0TPH1
21seasonal affective disorder10.0TPH1
22paranoid schizophrenia10.0COMT
23bulimia nervosa10.0COMT
24conduct disorder10.0COMT
25essential hypertension10.0COMT
26parkinson's disease10.0COMT
27autoimmune polyendocrine syndrome10.0TPH1
28stroke, ischemic10.0NRG1
29neuroepithelioma10.0NOS1
30autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.0TPH1, GAD1
31panic disorder10.0TPH1, COMT
32mental retardation10.0COMT, TPH1
33migraine10.0COMT, TPH1
34obsessive-compulsive disorder10.0COMT, TPH1
35bipolar disorder10.0TPH1, NOS1
36dementia10.0NOS1, COMT
37hyperphenylalaninemia10.0NOS1, TPH1
38obesity10.0COMT, NOS1
39impotence10.0NOS1, PRL
40substance dependence10.0COMT, TPH1
41anxiety disorder10.0TPH1, GAD1, COMT
42anorexia nervosa10.0PRL, COMT, TPH1
43hypoglycemia10.0COMT, GAD1, PRL
44epilepsy syndrome10.0GAD1, NOS1, TPH1
45ischemia10.0NRG1, NOS1, GAD1
46multiple sclerosis10.0COMT, NRG1, GAD1
47duchenne muscular dystrophy10.0NOS1, NRG1
48schizoaffective disorder10.0NOS1, DAOA, PRODH, PRL, COMT
49alzheimer's disease10.0COMT, NRG1, GAD1, TPH1, NOS1

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Clinical Features for Childhood-Onset Schizophrenia

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Drugs & Therapeutics for Childhood-Onset Schizophrenia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood-Onset Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Search CenterWatch for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

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Anatomical Context for Childhood-Onset Schizophrenia

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Animal Models for Childhood-Onset Schizophrenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6COMT, GAD1, PRODH, NRG1, NOS1, PRL
2MP:00053867.1TPH1, COMT, GAD1, PRL, PRODH, NRG1
3MP:00053766.9GAD1, PRL, PRODH, NRG1, NOS1, TPH1

Publications for Childhood-Onset Schizophrenia

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Genetic Variations for Childhood-Onset Schizophrenia

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Expression for genes affiliated with Childhood-Onset Schizophrenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9NRG1
2
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9.7TPH1, GAD1
39.7NOS1, PRODH
49.2TPH1, NOS1, GAD1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pergolide28 44 1112.3COMT
2dihydrobiopterin44 2411.0TPH1, NOS1
3sepiapterin44 2411.0NOS1, TPH1
4pterin44 2411.0TPH1, NOS1
5norepinephrine44 11 2412.0TPH1, PRL
6mdma4410.0PRL, TPH1
75-hydroxytryptophan4410.0TPH1, PRL
8maoa449.9COMT, TPH1
9fenfluramine28 44 1111.9TPH1, PRL
10tetrahydrobiopterin44 11 2411.9NOS1, TPH1
11l-tryptophan44 28 11 2412.9TPH1, PRL
12l-amino acid449.8TPH1, COMT
13mhpg449.8PRL, COMT
14s-nitroso-n-acetylpenicillamine449.8TPH1, NOS1
15pramipexole44 49 28 1112.7PRL, COMT
16tamoxifen44 49 28 1112.7COMT, NRG1
17gnrh449.7GAD1, NRG1
18cabergoline28 44 1111.7PRL, COMT
19apomorphine44 28 1111.6COMT, PRL
20valproate449.5PRL, GAD1
21methamphetamine44 49 1111.5COMT, NOS1, TPH1
22fluoxetine49 44 28 1112.5PRL, NOS1, TPH1
23carbidopa44 2810.5TPH1, PRL, COMT
24mptp449.5NOS1, GAD1, COMT
25risperidone28 44 49 59 11 2414.5PRL, COMT
26homovanillic acid44 2410.5COMT, PRL, TPH1
27paroxetine44 49 28 1112.5COMT, PRL, TPH1
28nicotine44 49 28 1112.5TPH1, NOS1, COMT
29valine449.5COMT, NOS1, TPH1
30bromocriptine28 44 1111.4COMT, PRL
31cocaine44 1110.4NOS1, PRL, COMT
32ascorbic acid44 2410.3TPH1, NOS1, COMT
33methionine449.3TPH1, GAD1, COMT
34pyridoxal 5-phosphate449.2GAD1, COMT
35nmda44 2810.2COMT, GAD1, DAOA, NOS1
36choline44 11 2411.1TPH1, NOS1, GAD1, COMT
37levodopa44 1110.1COMT, GAD1, PRL, TPH1
38gaba449.0TPH1, NOS1, NRG1, GAD1
395-hydroxytryptamine449.0COMT, PRL, NOS1, TPH1
40acetylcholine44 49 28 11 2413.0GAD1, NRG1, NOS1, TPH1
41clozapine44 28 49 1112.0NOS1, PRL, GAD1, COMT
42arginine448.9TPH1, NOS1, PRL, GAD1
43progesterone44 59 28 11 2412.9TPH1, NRG1, PRL, GAD1
44proline448.7DAOA, NRG1, PRODH, GAD1, COMT
45testosterone44 59 11 2411.7COMT, PRL, NRG1, NOS1
46oxygen44 249.5TPH1, NOS1, NRG1, GAD1
47cysteine448.5COMT, GAD1, NRG1, NOS1, TPH1
48estrogen448.4TPH1, NOS1, NRG1, PRL, COMT
49glutamate447.9COMT, GAD1, PRODH, NRG1, DAOA, NOS1
50dopamine44 28 11 2410.7TPH1, COMT, GAD1, PRL, NRG1, DAOA

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

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16Gene Ontology
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Biological processes related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1circadian rhythmGO:0076239.6PRL, TPH1
2multicellular organismal response to stressGO:0335559.4NOS1, PRL
3neurotransmitter biosynthetic processGO:0421369.1GAD1, NOS1, COMT
4response to drugGO:0424938.7GAD1, PRL, COMT

Products for genes affiliated with Childhood-Onset Schizophrenia

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Sources for Childhood-Onset Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet