MCID: CHL078
MIFTS: 41

Childhood-Onset Schizophrenia malady

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Summaries for Childhood-Onset Schizophrenia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pediatric schizophrenia (also known as childhood schizophrenia, childhood-onset schizophrenia, and... more...

MalaCards: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and attention deficit hyperactivity disorder. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Nuclear signaling by ERBB4 and Biogenic Amine Synthesis. The compounds maoa and dihydrobiopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Childhood-Onset Schizophrenia

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

childhood-onset schizophrenia 43
schizophrenia, childhood 62
childhood schizophrenia 43


Related Diseases for Childhood-Onset Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.5DAOA, TPH1, PRL, NOS1, GAD1, COMT
2attention deficit hyperactivity disorder30.8COMT
3mood disorder30.0COMT, TPH1, NRG1, DAOA, NOS1, GAD1
4psychotic disorder29.8NOS1, PRL, TPH1, DAOA, NRG1, COMT
5autism spectrum disorder10.4
6autistic disorder10.3
7blindness10.3
8landau-kleffner syndrome10.1
9neuronitis10.1
10schizotypal personality disorder10.1
11mutism10.1
12velocardiofacial syndrome10.1
13cerebritis10.1
14intellectual disability10.1
15neutropenia10.1
16personality disorder10.1
17pervasive developmental disorder10.1
18tic disorder10.1
19hyperprolinemia10.1
20tardive dyskinesia10.1
21early-onset schizophrenia10.1
22generalized anxiety disorder10.1TPH1
23seasonal affective disorder10.1TPH1
24autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1GAD1, TPH1
25neuroendocrine tumor10.0PRL
26substance dependence10.0TPH1, COMT
27obsessive-compulsive disorder10.0TPH1, COMT
28hyperphenylalaninemia10.0NOS1, TPH1
29panic disorder10.0COMT, TPH1
30bipolar disorder10.0TPH1, NOS1
31migraine10.0TPH1, COMT
32anxiety disorder10.0COMT, GAD1, TPH1
33duchenne muscular dystrophy10.0NRG1, NOS1
34encephalomyelitis10.0GAD1, NRG1
35impotence10.0PRL, NOS1
36epilepsy syndrome10.0TPH1, NOS1, GAD1
37multiple sclerosis10.0COMT, GAD1, NRG1
38anorexia nervosa10.0COMT, TPH1, PRL
39hypoglycemia10.0PRL, GAD1, COMT
40prion disease10.0NRG1, NOS1
41ischemia10.0NRG1, NOS1, GAD1
42non-small cell lung carcinoma9.9COMT, NRG1, NOS1
43parkinson's disease9.9GAD1, NOS1, COMT, TPH1
44lung cancer9.9NOS1, COMT, NRG1
45melanoma9.9NRG1, COMT, TPH1, NOS1
46schizoaffective disorder9.9DAOA, PRL, COMT, NOS1
47alzheimer's disease9.9NOS1, NRG1, COMT, TPH1, GAD1
48breast cancer9.8NRG1, COMT, GAD1, NOS1, PRL

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Symptoms for Childhood-Onset Schizophrenia

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Drugs & Therapeutics for Childhood-Onset Schizophrenia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

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Anatomical Context for Childhood-Onset Schizophrenia

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33MalaCards
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MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

33
Brain, Eye, Temporal lobe, Testes, Cortex, Cerebellum

Animal Models for Childhood-Onset Schizophrenia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5TPH1, NRG1, NOS1, GAD1
2MP:00053858.4NOS1, NRG1, COMT, TPH1
3MP:00053798.0NOS1, GAD1, NRG1, PRL
4MP:00053897.7PRL, COMT, NRG1, NOS1
5MP:00036317.5NOS1, GAD1, NRG1, COMT, PRL
6MP:00053867.3NOS1, GAD1, NRG1, COMT, PRL, TPH1
7MP:00053767.2GAD1, NRG1, COMT, TPH1, NOS1, PRL

Publications for Childhood-Onset Schizophrenia

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52PubMed
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Articles related to Childhood-Onset Schizophrenia:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. (23682251)
2013
2
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. (23770018)
2013
3
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. (23622854)
2013
4
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. (24391605)
2013
5
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. (21613381)
2013
6
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. (22675310)
2012
7
White matter integrity, language, and childhood onset schizophrenia. (22405729)
2012
8
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. (22032743)
2011
9
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. (21703497)
2011
10
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. (20479756)
2011
11
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. (21245087)
2011
12
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. (21031030)
2010
13
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. (20347912)
2010
14
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. (22147958)
2010
15
The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent. (19302770)
2009
16
Childhood-onset schizophrenia: insights from neuroimaging studies. (20566189)
2008
17
Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. (17906336)
2008
18
Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder. (17879154)
2008
19
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
20
Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. (16818861)
2006
21
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia. (16763011)
2006
22
Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study. (15854790)
2005
23
Superior temporal gyrus differences in childhood-onset schizophrenia. (15653266)
2005
24
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. (14706940)
2004
25
Annotation: childhood-onset schizophrenia: clinical and treatment issues. (14982235)
2004
26
Olanzapine treatment in chronic drug-resistant childhood-onset schizophrenia: an open-label study. (14642019)
2003
27
Progressive loss of cerebellar volume in childhood-onset schizophrenia. (12505811)
2003
28
Differentiating childhood-onset schizophrenia from psychotic mood disorders. (11589532)
2001
29
Childhood-onset schizophrenia: research update. (11816313)
2001
30
Treatment of childhood-onset schizophrenia with olanzapine. (10933117)
2000
31
Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. (10742651)
2000
32
Obstetrical complications and childhood-onset schizophrenia. (10518182)
1999
33
The ESSEN study of childhood-onset schizophrenia: selected results. (10546980)
1999
34
Childhood-onset schizophrenia: a follow-up study. (10546978)
1999
35
Continuous-processing related ERPS in adult schizophrenia: continuity with childhood onset schizophrenia. (10349042)
1999
36
Why does postpsychotic IQ decline in childhood-onset schizophrenia? (10588420)
1999
37
Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. (10206241)
1999
38
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. (10401513)
1999
39
Detection of polyglutamine expansion in a new acidic protein: a candidate for childhood onset schizophrenia? (10089010)
1999
40
Childhood-onset schizophrenia associated with parkinsonism in a patient with a microdeletion of chromosome 22. (9787744)
1998
41
Attention deficits in childhood-onset schizophrenia: reaction time studies. (9505042)
1998
42
Pubertal development and onset of psychosis in childhood onset schizophrenia. (9172272)
1997
43
Cerebral glucose metabolism in childhood onset schizophrenia. (9437771)
1997
44
Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. (8931918)
1996
45
Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase. (9179938)
1995
46
Childhood-onset schizophrenia: the severity of premorbid course. (7592264)
1995
47
Annotation: childhood-onset schizophrenia. (7868633)
1994
48
Family-expressed emotion, childhood-onset depression, and childhood-onset schizophrenia spectrum disorders: is expressed emotion a nonspecific correlate of child psychopathology or a specific risk factor for depression? (8064026)
1994
49
Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. (2289947)
1990
50
The search for the psychobiological substrate of childhood onset schizophrenia. (3760409)
1986

Variations for Childhood-Onset Schizophrenia

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Expression for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 5Cell Signaling Technology, 30KEGG
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Pathways related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NRG1, PRL
2
Show member pathways
catecholamine biosynthesis38
9.1COMT, TPH1, GAD1
39.0NOS1, TPH1, GAD1
4
Show member pathways
8.5NOS1, GAD1, COMT, TPH1
5
Show member pathways
8.5NOS1, GAD1, COMT, TPH1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1maoa459.9COMT, TPH1
2dihydrobiopterin45 2410.8NOS1, TPH1
3fluvoxamine45 51 1111.8TPH1, COMT
4sepiapterin45 2410.8NOS1, TPH1
5pterin45 2410.8NOS1, TPH1
6l-amino acid459.7COMT, TPH1
7mdma459.6PRL, TPH1
85-hydroxytryptophan459.6TPH1, PRL
9tetrahydrobiopterin45 24 1111.6NOS1, TPH1
10fenfluramine45 29 1111.5TPH1, PRL
11mhpg459.5PRL, COMT
12s-nitroso-n-acetylpenicillamine459.4TPH1, NOS1
13pergolide45 29 1111.4PRL, COMT
14l-tryptophan51 29 45 24 1113.4PRL, TPH1
15pramipexole45 29 51 1112.4PRL, COMT
16cabergoline45 29 1111.4COMT, PRL
17methamphetamine45 51 1111.3NOS1, COMT, TPH1
18mptp459.3NOS1, COMT, GAD1
19methionine459.3GAD1, TPH1, COMT
20nicotine45 29 51 1112.3TPH1, NOS1, COMT
21valine459.3NOS1, TPH1, COMT
22apomorphine29 45 1111.2PRL, COMT
23valproate459.2GAD1, PRL
24carbidopa45 2910.2PRL, TPH1, COMT
25ascorbic acid45 2410.2COMT, TPH1, NOS1
26homovanillic acid45 2410.2TPH1, PRL, COMT
27paroxetine45 51 29 1112.2COMT, TPH1, PRL
28fluoxetine45 51 29 1112.0PRL, NOS1, TPH1
29proline459.0DAOA, COMT, NRG1, GAD1
30gnrh459.0GAD1, NRG1, PRL
31choline45 24 1110.9TPH1, COMT, GAD1, NOS1
32cocaine45 119.9PRL, COMT, NOS1
33gaba458.9NOS1, GAD1, NRG1, TPH1
34acetylcholine45 51 29 24 1112.9NOS1, TPH1, GAD1, NRG1
35bromocriptine45 29 1110.8COMT, PRL
36oxygen45 249.7NRG1, NOS1, GAD1, TPH1
37levodopa45 119.7GAD1, COMT, PRL, TPH1
38progesterone45 29 61 24 1112.7NRG1, GAD1, TPH1, PRL
39estradiol45 24 1110.6GAD1, COMT, PRL
405-hydroxytryptamine458.5TPH1, NOS1, COMT, PRL
41norepinephrine45 24 1110.5TPH1, NOS1, COMT, PRL
42arginine458.5NOS1, PRL, TPH1, GAD1
43clozapine45 29 51 1111.5NOS1, GAD1, COMT, PRL
44nmda45 299.4COMT, NRG1, DAOA, NOS1, GAD1
45tamoxifen45 51 29 1111.4NOS1, NRG1, COMT, PRL
46testosterone45 61 24 1111.4NOS1, COMT, PRL, NRG1
47cysteine458.3COMT, GAD1, NOS1, TPH1, NRG1
48glutamate458.0GAD1, NOS1, NRG1, COMT, TPH1, DAOA
49estrogen458.0NOS1, NRG1, COMT, TPH1, PRL
50dopamine45 29 24 1110.2GAD1, NRG1, COMT, PRL, TPH1, DAOA

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

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16Gene Ontology
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Biological processes related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.1COMT, PRL
2neurotransmitter biosynthetic processGO:0421368.6NOS1, GAD1, COMT

Products for genes affiliated with Childhood-Onset Schizophrenia

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Sources for Childhood-Onset Schizophrenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet