MCID: CHL078
MIFTS: 37

Childhood-Onset Schizophrenia malady

Summaries for Childhood-Onset Schizophrenia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Pediatric schizophrenia (also known as childhood schizophrenia, childhood-onset schizophrenia, and... more...

MalaCards: Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to attention deficit hyperactivity disorder and hyperprolinemia. An important gene associated with Childhood-Onset Schizophrenia is DAOA (D-amino acid oxidase activator), and among its related pathways are Prolactin receptor signaling and Regulation of thyroid hormone activity. The compounds pergolide and dihydrobiopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Childhood-Onset Schizophrenia

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

childhood-onset schizophrenia 43
schizophrenia, childhood 61
childhood schizophrenia 43


Related Diseases for Childhood-Onset Schizophrenia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder30.7TPH1, COMT
2hyperprolinemia30.1PRODH
3velocardiofacial syndrome30.1PRODH, COMT
4autism spectrum disorder10.4
5early-onset schizophrenia10.4
6autistic disorder10.3
7landau-kleffner syndrome10.1
8schizotypal personality disorder10.1
9mutism10.1
10corpus callosum agenesis10.1
11tardive dyskinesia10.1
12schizophrenia 1310.1
13borderline personality disorder10.0TPH1
14irritable bowel syndrome10.0TPH1
15seasonal affective disorder10.0TPH1
16paranoid schizophrenia10.0COMT
17bulimia nervosa10.0COMT
18conduct disorder10.0COMT
19essential hypertension10.0COMT
20parkinson's disease10.0COMT
21autoimmune polyendocrine syndrome10.0TPH1
22stroke, ischemic10.0NRG1
23neuroepithelioma10.0NOS1
24autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.0TPH1, GAD1
25panic disorder10.0TPH1, COMT
26mental retardation10.0COMT, TPH1
27migraine10.0COMT, TPH1
28obsessive-compulsive disorder10.0COMT, TPH1
29dopa-responsive cervical dystonia10.0TPH1, NOS1
30dementia10.0NOS1, COMT
31hyperphenylalaninemia10.0NOS1, TPH1
32obesity10.0COMT, NOS1
33impotence10.0NOS1, PRL
34intellectual disability10.0UPF3B
35substance dependence10.0COMT, TPH1
36anxiety disorder10.0TPH1, GAD1, COMT
37anorexia nervosa10.0PRL, COMT, TPH1
38hypoglycemia10.0COMT, GAD1, PRL
39epilepsy syndrome10.0GAD1, NOS1, TPH1
40ischemia10.0NRG1, NOS1, GAD1
41multiple sclerosis10.0COMT, NRG1, GAD1
42duchenne muscular dystrophy10.0NOS1, NRG1
43schizoaffective disorder10.0NOS1, DAOA, PRODH, PRL, COMT
44alzheimer's disease10.0COMT, NRG1, GAD1, TPH1, NOS1
45mood disorder10.0NRG1, DAOA, NOS1, TPH1, GAD1, COMT
46bipolar disorder10.0NRG1, PRODH, DAOA, NOS1, TPH1, COMT
47psychotic disorder9.9PRL, TPH1, NOS1, DAOA, NRG1, PRODH
48schizophrenia9.9NRG1, DAOA, TPH1, NOS1, PRODH, COMT

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to childhood-onset schizophrenia

Clinical Features for Childhood-Onset Schizophrenia

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood-Onset Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Childhood-Onset Schizophrenia

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Search CenterWatch for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Anatomical Context for Childhood-Onset Schizophrenia

Sources:
33MalaCards
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MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

33
Brain, Cortex, Cerebellum, T cells, Cingulate cortex, Temporal lobe

Animal Models for Childhood-Onset Schizophrenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Childhood-Onset Schizophrenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6COMT, GAD1, PRODH, NRG1, NOS1, PRL
2MP:00053867.1TPH1, COMT, GAD1, PRL, PRODH, NRG1
3MP:00053766.9GAD1, PRL, PRODH, NRG1, NOS1, TPH1

Publications for Childhood-Onset Schizophrenia

Sources:
51PubMed
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Articles related to Childhood-Onset Schizophrenia:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Genetics of childhood-onset schizophrenia. (24012080)
2013
2
Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers. (23782130)
2013
3
Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. (23510445)
2013
4
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. (22675310)
2012
5
White matter integrity, language, and childhood onset schizophrenia. (22405729)
2012
6
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. (22214315)
2012
7
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. (22032743)
2011
8
Cerebellar development in childhood onset schizophrenia and non-psychotic siblings. (21803550)
2011
9
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. (21031030)
2010
10
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. (20347912)
2010
11
Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia. (19913390)
2010
12
Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. (19218893)
2009
13
Childhood-onset schizophrenia: insights from neuroimaging studies. (20566189)
2008
14
Sex chromosome anomalies in childhood onset schizophrenia: an update. (18800051)
2008
15
Total agenesis of the corpus callosum in a patient with childhood-onset schizophrenia. (18345433)
2007
16
Forty-two-years later: the outcome of childhood-onset schizophrenia. (16897595)
2007
17
Sleep disturbances in childhood-onset schizophrenia. (16730952)
2006
18
Hyperprolinemia is not associated with childhood onset schizophrenia. (16389584)
2006
19
Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study. (15854790)
2005
20
Superior temporal gyrus differences in childhood-onset schizophrenia. (15653266)
2005
21
Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members. (15653267)
2005
22
IQ stabilization in childhood-onset schizophrenia. (15913958)
2005
23
MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHD. (15685429)
2005
24
Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness? (15121482)
2004
25
Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. (15211625)
2004
26
Progressive loss of cerebellar volume in childhood-onset schizophrenia. (12505811)
2003
27
Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia. (12611841)
2003
28
Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia. (12544379)
2003
29
Corpus callosum development in childhood-onset schizophrenia. (12765750)
2003
30
Structural brain abnormalities specific to childhood-onset schizophrenia identified by neuroimaging techniques. (12075863)
2002
31
Childhood-onset schizophrenia: research update. (11816313)
2001
32
Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. (10742651)
2000
33
Lessons from childhood-onset schizophrenia. (10719143)
2000
34
Update on childhood-onset schizophrenia. (11122989)
2000
35
Olanzapine pharmacokinetics in pediatric and adolescent inpatients with childhood-onset schizophrenia. (10770461)
2000
36
Brain abnormalities observed in childhood-onset schizophrenia: a review of the structural magnetic resonance imaging literature. (10982495)
2000
37
Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. (10206241)
1999
38
Clinical and neurobiological correlates of cytogenetic abnormalities in childhood-onset schizophrenia. (10518169)
1999
39
Apolipoprotein E alleles in childhood-onset schizophrenia. (10206244)
1999
40
Childhood-onset schizophrenia: rare but worth studying. (10578456)
1999
41
Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents. (9549958)
1998
42
Childhood-onset schizophrenia: biological markers in relation to clinical characteristics. (8988960)
1997
43
The long-term course of childhood-onset schizophrenia: a 42-year followup. (9050117)
1997
44
Childhood-onset schizophrenia: the severity of premorbid course. (7592264)
1995
45
Annotation: childhood-onset schizophrenia. (7868633)
1994
46
Childhood-onset schizophrenia: timely neurobiological research. (7521867)
1994
47
Childhood-onset schizophrenia: history of the concept and recent studies. (7701279)
1994
48
The clinical presentation of childhood-onset schizophrenia. (7701273)
1994
49
Childhood-onset schizophrenia. (1352624)
1992
50
The search for the psychobiological substrate of childhood onset schizophrenia. (3760409)
1986

Genetic Variations for Childhood-Onset Schizophrenia

Expression for genes affiliated with Childhood-Onset Schizophrenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for genes affiliated with Childhood-Onset Schizophrenia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9NRG1
2
Hide members
9.7TPH1, GAD1
39.7NOS1, PRODH
49.2TPH1, NOS1, GAD1

Compounds for genes affiliated with Childhood-Onset Schizophrenia

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pergolide29 45 1112.3COMT
2dihydrobiopterin45 2411.0TPH1, NOS1
3sepiapterin45 2411.0TPH1, NOS1
4pterin45 2411.0NOS1, TPH1
5norepinephrine45 11 2412.0PRL, TPH1
6mdma4510.0TPH1, PRL
75-hydroxytryptophan459.9TPH1, PRL
8maoa459.9COMT, TPH1
9fenfluramine29 45 1111.9TPH1, PRL
10tetrahydrobiopterin45 11 2411.9NOS1, TPH1
11l-tryptophan45 29 11 2412.9TPH1, PRL
12l-amino acid459.8TPH1, COMT
13mhpg459.8COMT, PRL
14s-nitroso-n-acetylpenicillamine459.8TPH1, NOS1
15pramipexole45 50 29 1112.7PRL, COMT
16tamoxifen45 50 29 1112.7COMT, NRG1
17gnrh459.7GAD1, NRG1
18cabergoline29 45 1111.7COMT, PRL
19apomorphine45 29 1111.6PRL, COMT
20valproate459.5GAD1, PRL
21fluoxetine50 45 29 1112.5NOS1, TPH1, PRL
22methamphetamine45 50 1111.5TPH1, NOS1, COMT
23carbidopa45 2910.5PRL, COMT, TPH1
24mptp459.5GAD1, NOS1, COMT
25risperidone29 45 50 60 11 2414.5COMT, PRL
26homovanillic acid45 2410.5COMT, PRL, TPH1
27paroxetine45 50 29 1112.5PRL, TPH1, COMT
28nicotine45 50 29 1112.5TPH1, COMT, NOS1
29valine459.5COMT, NOS1, TPH1
30bromocriptine29 45 1111.4COMT, PRL
31cocaine45 1110.4COMT, PRL, NOS1
32ascorbic acid45 2410.3COMT, NOS1, TPH1
33methionine459.3GAD1, TPH1, COMT
34citalopram50 45 11 2412.3TPH1, PRL
35nmda45 2910.2DAOA, NOS1, GAD1, COMT
36choline45 11 2411.1COMT, GAD1, NOS1, TPH1
37levodopa45 1110.1TPH1, GAD1, COMT, PRL
38gaba459.0GAD1, NOS1, NRG1, TPH1
395-hydroxytryptamine459.0TPH1, NOS1, COMT, PRL
40acetylcholine45 50 29 11 2413.0TPH1, NOS1, GAD1, NRG1
41clozapine45 29 50 1112.0GAD1, PRL, COMT, NOS1
42arginine458.9GAD1, PRL, NOS1, TPH1
43progesterone45 60 29 11 2412.9NRG1, TPH1, PRL, GAD1
44proline458.7COMT, PRODH, NRG1, GAD1, DAOA
45testosterone45 60 11 2411.7PRL, COMT, NRG1, NOS1
46oxygen45 249.5NOS1, NRG1, GAD1, TPH1
47cysteine458.5NRG1, NOS1, TPH1, GAD1, COMT
48estrogen458.4PRL, NOS1, NRG1, TPH1, COMT
49glutamate457.9NRG1, COMT, PRODH, NOS1, TPH1, GAD1
50dopamine45 29 11 2410.7NRG1, NOS1, TPH1, PRL, GAD1, COMT

GO Terms for genes affiliated with Childhood-Onset Schizophrenia

Sources:
16Gene Ontology
See all sources

Biological processes related to Childhood-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1circadian rhythmGO:0076239.6TPH1, PRL
2multicellular organismal response to stressGO:0335559.4NOS1, PRL
3neurotransmitter biosynthetic processGO:0421369.1NOS1, GAD1, COMT
4response to drugGO:0424938.7COMT, GAD1, PRL

Products for genes affiliated with Childhood-Onset Schizophrenia

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  • Lysates
  • Antibodies

Sources for Childhood-Onset Schizophrenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet