MCID: CHL078
MIFTS: 31

Childhood-Onset Schizophrenia

Categories: Rare diseases

Aliases & Classifications for Childhood-Onset Schizophrenia

MalaCards integrated aliases for Childhood-Onset Schizophrenia:

Name: Childhood-Onset Schizophrenia 50 29
Schizophrenia, Childhood 69
Childhood Schizophrenia 50

Classifications:



Summaries for Childhood-Onset Schizophrenia

MalaCards based summary : Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to personality disorder and schizophrenia. An important gene associated with Childhood-Onset Schizophrenia is TPH1 (Tryptophan Hydroxylase 1), and among its related pathways/superpathways are Neuroscience and Biogenic Amine Synthesis. The drugs Clozapine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye.

Related Diseases for Childhood-Onset Schizophrenia

Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.6 COMT GAD1 NRG1
2 schizophrenia 28.2 COMT DAOA GAD1 GPR153 NRG1 PRL
3 landau-kleffner syndrome 10.8
4 renpenning syndrome 10.5 COMT TPH1
5 hypertrichosis lanuginosa congenita 10.5 COMT PRODH
6 myopathy, distal, with early respiratory failure, autosomal dominant 10.5 COMT TPH1
7 obsessive-compulsive personality disorder 10.5 COMT TPH1
8 placenta accreta 10.5 COMT TPH1
9 keratosis 10.4 COMT TPH1
10 chronic dacryoadenitis 10.4 COMT PRL
11 giant cell reparative granuloma 10.4 COMT NRG1
12 unilateral hyperactive labyrinth 10.4 COMT GAD1
13 carotid stenosis 10.4 COMT TPH1
14 phaeohyphomycosis 10.4 GAD1 TPH1
15 primary angle-closure glaucoma 10.3 COMT NRG1
16 cecal benign neoplasm 10.3 COMT TPH1
17 haverhill fever 10.3 COMT PRL
18 may-hegglin anomaly 10.2 COMT TPH1
19 colon mucinous adenocarcinoma 10.2 COMT PRL
20 aicardi-goutieres syndrome 2 10.2 COMT PRL TPH1
21 bladder flat intraepithelial lesion 10.2 PRL PRODH
22 rhinoscleroma 10.1 COMT NRG1 PRL
23 attention deficit-hyperactivity disorder 10.1
24 plague 10.0 COMT PRL
25 partial motor epilepsy 10.0 COMT DAOA TPH1
26 autism spectrum disorder 10.0
27 parkinson disease, late-onset 10.0 COMT GAD1 TPH1
28 parkinsonism-dystonia, infantile 9.9 COMT TPH1
29 autistic disorder 9.9
30 velocardiofacial syndrome 9.7
31 neutropenia 9.7
32 pervasive developmental disorder 9.7
33 schizotypal personality disorder 9.7
34 psychotic disorder 9.7
35 tic disorder 9.7
36 mood disorder 9.7
37 cerebritis 9.7
38 mutism 9.7
39 neuronitis 9.7
40 hyperprolinemia 9.7
41 tardive dyskinesia 9.7
42 intellectual disability 9.7
43 early-onset schizophrenia 9.7
44 bone fracture 8.9 COMT DAOA GAD1 NRG1 PRODH TPH1
45 chronic conjunctivitis 8.5 COMT DAOA GAD1 NRG1 PRL PRODH
46 chitty hall webb syndrome 6.5 COMT DAOA GAD1 GPR153 NRG1 PRL

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to Childhood-Onset Schizophrenia

Symptoms & Phenotypes for Childhood-Onset Schizophrenia

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Drugs for Childhood-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clozapine Approved Phase 4 5786-21-0 2818
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3 Antiemetics Phase 4
4 Antipsychotic Agents Phase 4
5 Autonomic Agents Phase 4
6 Central Nervous System Depressants Phase 4
7 GABA Agents Phase 4
8 Gastrointestinal Agents Phase 4
9 Neurotransmitter Agents Phase 4,Phase 2
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Psychotropic Drugs Phase 4
13
Serotonin Phase 4 50-67-9 5202
14 Serotonin Agents Phase 4
15 Serotonin Antagonists Phase 4
16 Serotonin Uptake Inhibitors Phase 4
17 Tranquilizing Agents Phase 4
18 Antibodies Phase 3
19 gamma-Globulins Phase 3
20 Immunoglobulins Phase 3
21 Immunoglobulins, Intravenous Phase 3
22 Rho(D) Immune Globulin Phase 3
23
Oxytocin Approved, Vet_approved Phase 1, Phase 2 50-56-6 439302 53477758
24
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
25 Oxytocics Phase 1, Phase 2
26
Epinephrine Approved, Vet_approved 51-43-4 5816
27 Racepinephrine Approved
28 Epinephryl borate

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Treating Drug-Resistant Childhood Schizophrenia Completed NCT00048828 Phase 4 Olanzapine;Clozapine
2 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed NCT00001656 Phase 4 Olanzapine;Clozapine
3 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3 Intravenous immunoglobulin
4 Glycine to Treat Psychotic Disorders in Children Completed NCT00005658 Phase 2 Glycine
5 Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia Terminated NCT01712646 Phase 1, Phase 2 Intranasal Oxytocin
6 Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia Terminated NCT00757497 Phase 1
7 Exploration and Characterization of Genetic and Phenotypic Profile of the"Schizotiste" Unknown status NCT02565524
8 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
9 Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers Recruiting NCT00001246
10 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Terminated NCT00001198
11 Screening for Childhood-Onset Psychotic Disorders Terminated NCT00049738

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Genetic tests related to Childhood-Onset Schizophrenia:

id Genetic test Affiliating Genes
1 Childhood-Onset Schizophrenia 29

Anatomical Context for Childhood-Onset Schizophrenia

MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

39
Brain, Temporal Lobe, Eye, Testes, Cortex, Cerebellum

Publications for Childhood-Onset Schizophrenia

Articles related to Childhood-Onset Schizophrenia:

(show top 50) (show all 180)
id Title Authors Year
1
DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 27829189 )
2016
2
Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. ( 26784704 )
2016
3
A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia. ( 27626066 )
2016
4
Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. ( 27566120 )
2016
5
Altered intra- and inter-network dynamics reflect symptom dimensions in childhood-onset schizophrenia. ( 26747855 )
2016
6
15q13.3 duplication in two patients with childhood-onset schizophrenia. ( 26968334 )
2016
7
Childhood-onset schizophrenia case with 2.2A Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28. ( 25914809 )
2015
8
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings. ( 25819937 )
2015
9
Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia. ( 25936396 )
2015
10
De novo variants in sporadic cases of childhood onset schizophrenia. ( 26508570 )
2015
11
Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia. ( 26234702 )
2015
12
Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. ( 26493637 )
2015
13
Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 25541139 )
2015
14
Comparing Fractional Anisotropy in Patients With Childhood-Onset Schizophrenia, Their Healthy Siblings, and Normal Volunteers Through DTI. ( 25217482 )
2014
15
Childhood-onset schizophrenia: what do we really know? ( 25750815 )
2014
16
Common polygenic variation and risk for childhood-onset schizophrenia. ( 25510512 )
2014
17
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. ( 25019955 )
2014
18
Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. ( 23510445 )
2013
19
Evidence for Corticostriatal Dysfunction During Cognitive Skill Learning in Adolescent Siblings of Patients With Childhood-Onset Schizophrenia. ( 24162516 )
2013
20
High circulatory titer of platelet-associated autoantibodies in childhood onset schizophrenia and its diagnostic implications. ( 23881299 )
2013
21
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. ( 23682251 )
2013
22
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. ( 23821644 )
2013
23
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. ( 21613381 )
2013
24
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. ( 23622854 )
2013
25
Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers. ( 23782130 )
2013
26
Violence in childhood-onset schizophrenia. ( 25478126 )
2013
27
Genetics of childhood-onset schizophrenia. ( 24012080 )
2013
28
Childhood onset schizophrenia and early onset schizophrenia spectrum disorders. ( 24012072 )
2013
29
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. ( 24391605 )
2013
30
Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings. ( 23154096 )
2013
31
High rate of disease-related copy number variations in childhood onset schizophrenia. ( 23689535 )
2013
32
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. ( 23770018 )
2013
33
Aspirin as an adjunctive treatment for childhood onset schizophrenia. ( 24138014 )
2013
34
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 22945617 )
2012
35
White matter integrity, language, and childhood onset schizophrenia. ( 22405729 )
2012
36
17 years of treatment-resistant mutism in non-catatonic, childhood-onset schizophrenia: a rare case report. ( 22450644 )
2012
37
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
38
A case report on the relationship between treatment-resistant childhood-onset schizophrenia and an abnormally enlarged cavum septum pellucidum combined with cavum vergae. ( 22613614 )
2012
39
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. ( 22675310 )
2012
40
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. ( 21245087 )
2011
41
Cerebellar development in childhood onset schizophrenia and non-psychotic siblings. ( 21803550 )
2011
42
Childhood onset schizophrenia: high rate of visual hallucinations. ( 21703495 )
2011
43
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. ( 21620981 )
2011
44
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. ( 22032743 )
2011
45
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. ( 20479756 )
2011
46
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 21703497 )
2011
47
Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. ( 20955775 )
2011
48
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. ( 20347912 )
2010
49
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. ( 21031030 )
2010
50
Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI. ( 22147958 )
2010

Variations for Childhood-Onset Schizophrenia

Expression for Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for Childhood-Onset Schizophrenia

Pathways related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.64 COMT GAD1 TPH1
2
Show member pathways
10.14 COMT GAD1 TPH1

GO Terms for Childhood-Onset Schizophrenia

Cellular components related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.96 COMT NRG1
2 axon GO:0030424 8.8 COMT GAD1 NRG1

Sources for Childhood-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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