MCID: CHL078
MIFTS: 35

Childhood-Onset Schizophrenia

Categories: Rare diseases

Aliases & Classifications for Childhood-Onset Schizophrenia

MalaCards integrated aliases for Childhood-Onset Schizophrenia:

Name: Childhood-Onset Schizophrenia 49 28
Schizophrenia, Childhood 69
Childhood Schizophrenia 49

Classifications:



External Ids:

UMLS 69 C0036346

Summaries for Childhood-Onset Schizophrenia

MalaCards based summary : Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to hyperprolinemia and personality disorder. An important gene associated with Childhood-Onset Schizophrenia is TPH1 (Tryptophan Hydroxylase 1), and among its related pathways/superpathways are Neuroscience and Biogenic Amine Synthesis. The drugs Olanzapine and Clozapine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye.

Wikipedia : 72 Childhood schizophrenia (also known as childhood-onset schizophrenia, and very early-onset... more...

Related Diseases for Childhood-Onset Schizophrenia

Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 hyperprolinemia 30.2 COMT PRODH
2 personality disorder 30.0 COMT TPH1
3 mood disorder 29.7 COMT DAOA TPH1
4 schizophrenia 29.1 COMT DAOA GAD1 GPR153 NRG1 PRL
5 psychotic disorder 28.5 COMT DAOA NRG1 PRL PRODH TPH1
6 landau-kleffner syndrome 10.9
7 brunner syndrome 10.3 COMT TPH1
8 kleine-levin hibernation syndrome 10.3 COMT TPH1
9 borderline personality disorder 10.3 COMT TPH1
10 mammographic density 10.3 COMT PRL
11 somatoform disorder 10.3 COMT TPH1
12 cannabis dependence 10.3 COMT NRG1
13 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.3 GAD1 TPH1
14 postpartum depression 10.3 COMT PRL
15 mental depression 10.3 COMT TPH1
16 conversion disorder 10.2 COMT GAD1
17 conduct disorder 10.2 COMT TPH1
18 autoimmune polyendocrine syndrome 10.2 GAD1 TPH1
19 bipolar i disorder 10.2 COMT NRG1
20 autism 10.2
21 attention deficit-hyperactivity disorder 10.1
22 substance abuse 10.1 COMT PRL
23 obsessive-compulsive disorder 10.1 COMT PRL TPH1
24 bulimia nervosa 2 10.1 COMT PRL
25 autism spectrum disorder 10.0
26 schizophreniform disorder 10.0 COMT NRG1 PRL
27 alcohol dependence 10.0 COMT GAD1 TPH1
28 breast disease 10.0 COMT PRL
29 disease of mental health 10.0 COMT GAD1 NRG1
30 tobacco addiction 9.9 COMT TPH1
31 parkinson disease, late-onset 9.8 COMT GAD1 TPH1
32 velocardiofacial syndrome 9.8
33 tardive dyskinesia 9.8
34 cognitive function 1, social 9.8
35 alacrima, achalasia, and mental retardation syndrome 9.8
36 neutropenia 9.8
37 pervasive developmental disorder 9.8
38 schizotypal personality disorder 9.8
39 tic disorder 9.8
40 cerebritis 9.8
41 mutism 9.8
42 neuronitis 9.8
43 early-onset schizophrenia 9.8
44 major depressive disorder 9.8 COMT GAD1 PRL TPH1
45 schizoaffective disorder 9.7 COMT DAOA PRL PRODH
46 bipolar disorder 8.8 COMT DAOA GAD1 NRG1 PRL PRODH

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to Childhood-Onset Schizophrenia

Symptoms & Phenotypes for Childhood-Onset Schizophrenia

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Drugs for Childhood-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
2
Clozapine Approved Phase 4 5786-21-0 2818
3
Serotonin Phase 4 50-67-9 5202
4 Central Nervous System Depressants Phase 4
5 Serotonin Agents Phase 4
6 Serotonin Antagonists Phase 4
7 Serotonin Uptake Inhibitors Phase 4
8 GABA Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 Neurotransmitter Agents Phase 4
11 Tranquilizing Agents Phase 4
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Antiemetics Phase 4
15 Psychotropic Drugs Phase 4
16 Antipsychotic Agents Phase 4
17 Autonomic Agents Phase 4
18 Rho(D) Immune Globulin Phase 3
19 gamma-Globulins Phase 3
20 Immunoglobulins Phase 3
21 Immunoglobulins, Intravenous Phase 3
22 Antibodies Phase 3
23
Oxytocin Approved, Vet_approved Phase 1, Phase 2 50-56-6 53477758 439302
24 Oxytocics Phase 1, Phase 2
25
Epinephrine Approved, Vet_approved 51-43-4 5816
26 Racepinephrine Approved 329-65-7
27 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treating Drug-Resistant Childhood Schizophrenia Completed NCT00048828 Phase 4 Olanzapine;Clozapine
2 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed NCT00001656 Phase 4 Olanzapine;Clozapine
3 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3 Intravenous immunoglobulin
4 Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia Terminated NCT01712646 Phase 1, Phase 2 Intranasal Oxytocin
5 Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia Terminated NCT00757497 Phase 1
6 Exploration and Characterization of Genetic and Phenotypic Profile of the"Schizotiste" Unknown status NCT02565524
7 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
8 Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers Recruiting NCT00001246
9 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Terminated NCT00001198
10 Screening for Childhood-Onset Psychotic Disorders Terminated NCT00049738

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Genetic tests related to Childhood-Onset Schizophrenia:

# Genetic test Affiliating Genes
1 Childhood-Onset Schizophrenia 28

Anatomical Context for Childhood-Onset Schizophrenia

MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

38
Brain, Temporal Lobe, Eye, Testes, Cortex, Cerebellum

Publications for Childhood-Onset Schizophrenia

Articles related to Childhood-Onset Schizophrenia:

(show top 50) (show all 181)
# Title Authors Year
1
Symptom dimensions and subgroups in childhood-onset schizophrenia. ( 29146021 )
2017
2
15q13.3 duplication in two patients with childhood-onset schizophrenia. ( 26968334 )
2016
3
Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. ( 26784704 )
2016
4
Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. ( 27566120 )
2016
5
DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 27829189 )
2016
6
Altered intra- and inter-network dynamics reflect symptom dimensions in childhood-onset schizophrenia. ( 26747855 )
2016
7
A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia. ( 27626066 )
2016
8
Childhood-onset schizophrenia case with 2.2A Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28. ( 25914809 )
2015
9
Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia. ( 26234702 )
2015
10
Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia. ( 25936396 )
2015
11
De novo variants in sporadic cases of childhood onset schizophrenia. ( 26508570 )
2015
12
Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. ( 26493637 )
2015
13
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings. ( 25819937 )
2015
14
Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 25541139 )
2015
15
Childhood-onset schizophrenia: what do we really know? ( 25750815 )
2014
16
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. ( 25019955 )
2014
17
Common polygenic variation and risk for childhood-onset schizophrenia. ( 25510512 )
2014
18
Comparing Fractional Anisotropy in Patients With Childhood-Onset Schizophrenia, Their Healthy Siblings, and Normal Volunteers Through DTI. ( 25217482 )
2014
19
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. ( 23682251 )
2013
20
High rate of disease-related copy number variations in childhood onset schizophrenia. ( 23689535 )
2013
21
Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings. ( 23154096 )
2013
22
Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers. ( 23782130 )
2013
23
High circulatory titer of platelet-associated autoantibodies in childhood onset schizophrenia and its diagnostic implications. ( 23881299 )
2013
24
Genetics of childhood-onset schizophrenia. ( 24012080 )
2013
25
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. ( 21613381 )
2013
26
Aspirin as an adjunctive treatment for childhood onset schizophrenia. ( 24138014 )
2013
27
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. ( 23770018 )
2013
28
Childhood onset schizophrenia and early onset schizophrenia spectrum disorders. ( 24012072 )
2013
29
Evidence for Corticostriatal Dysfunction During Cognitive Skill Learning in Adolescent Siblings of Patients With Childhood-Onset Schizophrenia. ( 24162516 )
2013
30
Violence in childhood-onset schizophrenia. ( 25478126 )
2013
31
Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. ( 23510445 )
2013
32
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. ( 23622854 )
2013
33
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. ( 24391605 )
2013
34
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. ( 23821644 )
2013
35
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 22945617 )
2012
36
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. ( 22675310 )
2012
37
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
38
17 years of treatment-resistant mutism in non-catatonic, childhood-onset schizophrenia: a rare case report. ( 22450644 )
2012
39
A case report on the relationship between treatment-resistant childhood-onset schizophrenia and an abnormally enlarged cavum septum pellucidum combined with cavum vergae. ( 22613614 )
2012
40
White matter integrity, language, and childhood onset schizophrenia. ( 22405729 )
2012
41
Cerebellar development in childhood onset schizophrenia and non-psychotic siblings. ( 21803550 )
2011
42
Childhood onset schizophrenia: high rate of visual hallucinations. ( 21703495 )
2011
43
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 21703497 )
2011
44
Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. ( 20955775 )
2011
45
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. ( 21245087 )
2011
46
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. ( 21620981 )
2011
47
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. ( 20479756 )
2011
48
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. ( 22032743 )
2011
49
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. ( 20347912 )
2010
50
Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. ( 21031030 )
2010

Variations for Childhood-Onset Schizophrenia

Expression for Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for Childhood-Onset Schizophrenia

Pathways related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 COMT GAD1 TPH1
2
Show member pathways
10.14 COMT GAD1 TPH1

GO Terms for Childhood-Onset Schizophrenia

Cellular components related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.96 COMT NRG1
2 axon GO:0030424 8.8 COMT GAD1 NRG1

Sources for Childhood-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....