JDM
MCID: CHL028
MIFTS: 31

Childhood Type Dermatomyositis (JDM) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Skin diseases, Muscle diseases categories
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Summaries for Childhood Type Dermatomyositis

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NIH Rare Diseases:42 Juvenile dermatomyositis has some similarities to adult dermatomyositis and polymyositis. it typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and contractures. children with juvenile dermatomyositis may have difficulty swallowing and breathing, and the heart may also be affected.  about 20 to 30 percent of children with juvenile dermatomyositis develop calcium deposits in the soft tissue. affected children may not show higher than normal levels of the muscle enzyme creatine kinase in their blood but have higher than normal levels of other muscle enzymes. last updated: 5/31/2011

MalaCards based summary: Childhood Type Dermatomyositis, also known as juvenile dermatomyositis, is related to arthritis and interstitial lung disease, and has symptoms including palpebral edema/periorbital edema, dry/squaly skin/exfoliation and cutaneous rash. Affiliated tissues include skin, heart and lung.

Aliases & Classifications for Childhood Type Dermatomyositis

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Childhood Type Dermatomyositis, Aliases & Descriptions:

Name: Childhood Type Dermatomyositis 30 8
Juvenile Dermatomyositis 8 42 48 62
Juvenile Polymyositis 42 48
Dermatomyositis, Childhood Type 62
Childhood Dermatomyositis 8
 
Juvenile Myositis 42
Juvenile Pm 48
Juvenile Dm 48
Jdm 42
Jpm 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
juvenile dermatomyositis:
Age of onset: Childhood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:14203
NCIt39 C27576
MeSH34 D003882
ICD10 via Orphanet26 M33.2, M33.0
SNOMED-CT57 1212005, 201446001
MESH via Orphanet35 C538250
UMLS via Orphanet63 C0263666, C2931785
ICD1025 M33.0

Related Diseases for Childhood Type Dermatomyositis

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Graphical network of the top 20 diseases related to Childhood Type Dermatomyositis:



Diseases related to childhood type dermatomyositis

Symptoms for Childhood Type Dermatomyositis

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Symptoms:

48 (show all 44)
  • palpebral edema/periorbital edema
  • dry/squaly skin/exfoliation
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • telangiectasiae of the skin
  • telangiectasiae of mucosae
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • periarticular tissue anomaly/extraarticular calcifications
  • autoimmunity/autoimmune reaction/autoantibodies
  • asthenia/fatigue/weakness
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic skin infection/ulcerations/ulcers/cancrum
  • skin photosensitivity
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • telangiectasic erythema/poikiloderma
  • alopecia
  • constipation
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • vascularitis/vasculitides/arteritis
  • hypotonia
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • articular/joint pain/arthralgia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • abnormal cry/voice/phonation disorder/nasal speech
  • cardiomyopathy/hypertrophic/dilated
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • angor pectoris/myocardial infarction
  • elocution disorders/dysarthria/dysphonia
  • abnormal emg/electromyogram/electropmyography
  • restricted joint mobility/joint stiffness/ankylosis
  • weight loss/loss of appetite/break in weight curve/general health alteration

HPO human phenotypes related to Childhood Type Dermatomyositis:

(show all 36)
id Description Frequency HPO Source Accession
1 chondrocalcinosis hallmark (90%) HP:0000934
2 dry skin hallmark (90%) HP:0000958
3 skin rash hallmark (90%) HP:0000988
4 muscle weakness hallmark (90%) HP:0001324
5 autoimmunity hallmark (90%) HP:0002960
6 myalgia hallmark (90%) HP:0003326
7 periorbital edema hallmark (90%) HP:0100539
8 mucosal telangiectasiae hallmark (90%) HP:0100579
9 teleangiectasia of the skin hallmark (90%) HP:0100585
10 pruritus typical (50%) HP:0000989
11 cutaneous photosensitivity typical (50%) HP:0000992
12 poikiloderma typical (50%) HP:0001029
13 muscular hypotonia typical (50%) HP:0001252
14 arthritis typical (50%) HP:0001369
15 flexion contracture typical (50%) HP:0001371
16 alopecia typical (50%) HP:0001596
17 constipation typical (50%) HP:0002019
18 restrictive lung disease typical (50%) HP:0002091
19 vasculitis typical (50%) HP:0002633
20 arthralgia typical (50%) HP:0002829
21 abnormality of temperature regulation typical (50%) HP:0004370
22 skin ulcer typical (50%) HP:0200042
23 limitation of joint mobility occasional (7.5%) HP:0001376
24 abnormality of the voice occasional (7.5%) HP:0001608
25 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
26 coronary artery disease occasional (7.5%) HP:0001677
27 abnormality of the pericardium occasional (7.5%) HP:0001697
28 weight loss occasional (7.5%) HP:0001824
29 abdominal pain occasional (7.5%) HP:0002027
30 respiratory insufficiency occasional (7.5%) HP:0002093
31 neurological speech impairment occasional (7.5%) HP:0002167
32 pulmonary fibrosis occasional (7.5%) HP:0002206
33 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
34 emg abnormality occasional (7.5%) HP:0003457
35 feeding difficulties in infancy occasional (7.5%) HP:0008872
36 arrhythmia occasional (7.5%) HP:0011675

Drugs & Therapeutics for Childhood Type Dermatomyositis

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Drug clinical trials:

Search ClinicalTrials for Childhood Type Dermatomyositis

Search NIH Clinical Center for Childhood Type Dermatomyositis

Genetic Tests for Childhood Type Dermatomyositis

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Anatomical Context for Childhood Type Dermatomyositis

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MalaCards organs/tissues related to Childhood Type Dermatomyositis:

32
Skin, Heart, Lung, Bone

Animal Models for Childhood Type Dermatomyositis or affiliated genes

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Publications for Childhood Type Dermatomyositis

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Variations for Childhood Type Dermatomyositis

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Expression for genes affiliated with Childhood Type Dermatomyositis

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Search GEO for disease gene expression data for Childhood Type Dermatomyositis.

Pathways for genes affiliated with Childhood Type Dermatomyositis

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Compounds for genes affiliated with Childhood Type Dermatomyositis

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GO Terms for genes affiliated with Childhood Type Dermatomyositis

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Products for genes affiliated with Childhood Type Dermatomyositis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Childhood Type Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet