JDM
MCID: CHL028
MIFTS: 33

Childhood Type Dermatomyositis (JDM) malady

Neuronal, Nephrological, Respiratory, Bone, Skin categories

Summaries for Childhood Type Dermatomyositis

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Juvenile dermatomyositis has some similarities to adult dermatomyositis and polymyositis. it typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and contractures. children with juvenile dermatomyositis may have difficulty swallowing and breathing, and the heart may also be affected.  about 20 to 30 percent of children with juvenile dermatomyositis develop calcium deposits in the soft tissue. affected children may not show higher than normal levels of the muscle enzyme creatine kinase in their blood but have higher than normal levels of other muscle enzymes. last updated: 5/31/2011

MalaCards: Childhood Type Dermatomyositis, also known as juvenile dermatomyositis, is related to arthritis and polymyositis, and has symptoms including feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia, constipation and elocution disorders/dysarthria/dysphonia. An important gene associated with Childhood Type Dermatomyositis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are Immune response NFAT in immune response and CD28 co-stimulation. Affiliated tissues include skin and heart.

Aliases & Classifications for Childhood Type Dermatomyositis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Respiratory, Bone, Skin


Characteristics (Orphanet epidemiological data):

49
juvenile dermatomyositis:
Age of onset: Childhood


Aliases & Descriptions:

childhood type dermatomyositis 8
juvenile dermatomyositis 8 43 49 61
juvenile polymyositis 43 49
dermatomyositis, childhood type 61
childhood dermatomyositis 8
juvenile myositis 43
juvenile dm 49
juvenile pm 49
jdm 43
jpm 43


External Ids:

Disease Ontology8 DOID:14203
MeSH35 D003882
NCIt40 C27576
ICD10 via Orphanet26 M33.2, M33.0
SNOMED-CT57 1212005, 201446001
SNOMED-CT via Orphanet58 1212005
UMLS via Orphanet62 C0263666, C2931785
ICD1025 M33.0

Related Diseases for Childhood Type Dermatomyositis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Childhood Type Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis10.5
2polymyositis10.4
3systemic lupus erythematosus10.3
4juvenile rheumatoid arthritis10.3
5juvenile scleroderma10.2
6mixed connective tissue disease10.0
7inclusion body myositis10.0
8myositis ossificans10.0
9oral candidiasis10.0
10n syndrome10.0
11vascular disease10.0
12idiopathic myopathy10.0
13epidermal nevus10.0
14pulmonary function10.0
15teratoma10.0
16rheumatic disease10.0
17fibrodysplasia ossificans progressiva10.0
18adult dermatomyositis10.0
19vitiligo10.0STX17

Graphical network of diseases related to Childhood Type Dermatomyositis:



Diseases related to childhood type dermatomyositis

Clinical Features for Childhood Type Dermatomyositis

Sources:
49Orphanet
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Symptoms:

49 (show all 44)
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • elocution disorders/dysarthria/dysphonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hypotonia
  • muscle weakness/flaccidity
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • asthenia/fatigue/weakness
  • fever/chilling
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • abnormal cry/voice/phonation disorder/nasal speech
  • lung fibrosis
  • cardiomyopathy/hypertrophic/dilated
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • telangiectasiae of the skin
  • skin photosensitivity
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • telangiectasiae of mucosae
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • periarticular tissue anomaly/extraarticular calcifications
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • vascularitis/vasculitides/arteritis
  • palpebral edema/periorbital edema
  • alopecia
  • telangiectasic erythema/poikiloderma

Drugs & Therapeutics for Childhood Type Dermatomyositis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Childhood Type Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Childhood Type Dermatomyositis

Search NIH Clinical Center for Childhood Type Dermatomyositis

Search CenterWatch for Childhood Type Dermatomyositis

Genetic Tests for Childhood Type Dermatomyositis

Anatomical Context for Childhood Type Dermatomyositis

Sources:
33MalaCards
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MalaCards organs/tissues related to Childhood Type Dermatomyositis:

33
Skin, Heart

Animal Models for Childhood Type Dermatomyositis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Childhood Type Dermatomyositis

Genetic Variations for Childhood Type Dermatomyositis

Expression for genes affiliated with Childhood Type Dermatomyositis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Childhood Type Dermatomyositis

Search GEO for disease gene expression data for Childhood Type Dermatomyositis.

Pathways for genes affiliated with Childhood Type Dermatomyositis

Sources:
12EMD Millipore, 54Reactome, 52QIAGEN, 30KEGG
See all sources

Pathways related to Childhood Type Dermatomyositis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response NFAT in immune response
Hide members
9.2HLA-DQA2, HLA-DQA1
2
Hide members
9.2HLA-DQA1, HLA-DQA2
3
Immune response ICOS pathway in T-helper cell
Hide members
9.2HLA-DQA1, HLA-DQA2
49.2HLA-DQA1, HLA-DQA2
5
Hide members
9.2HLA-DQA1, HLA-DQA2
69.2HLA-DQA1, HLA-DQA2
79.2HLA-DQA1, HLA-DQA2
89.2HLA-DQA1, HLA-DQA2
99.2HLA-DQA2, HLA-DQA1
10
Hide members
9.2HLA-DQA1, HLA-DQA2
11
Immune response Antigen presentation by MHC class II
Hide members
9.2HLA-DQA1, HLA-DQA2
129.2HLA-DQA2, HLA-DQA1
139.2HLA-DQA1, HLA-DQA2
149.2HLA-DQA1, HLA-DQA2
15
Hide members
9.2HLA-DQA1, HLA-DQA2
16
Hide members
8.7HLA-DQA1, HLA-DQA2, IFIT3

Compounds for genes affiliated with Childhood Type Dermatomyositis

GO Terms for genes affiliated with Childhood Type Dermatomyositis

Sources:
16Gene Ontology
See all sources

Cellular components related to Childhood Type Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DQA1, HLA-DQA2
2clathrin-coated endocytic vesicle membraneGO:0306699.4HLA-DQA2, HLA-DQA1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DQA1, HLA-DQA2
4transport vesicle membraneGO:0306589.2HLA-DQA2, HLA-DQA1
5endosome membraneGO:0100089.2HLA-DQA2, HLA-DQA1
6trans-Golgi network membraneGO:0325889.1HLA-DQA1, HLA-DQA2
7endocytic vesicle membraneGO:0306668.9HLA-DQA2, HLA-DQA1
8ER to Golgi transport vesicle membraneGO:0125078.9STX17, HLA-DQA2, HLA-DQA1
9lysosomal membraneGO:0057658.9STX17, HLA-DQA2, HLA-DQA1

Biological processes related to Childhood Type Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:0603339.2HLA-DQA1, HLA-DQA2
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.2HLA-DQA2, HLA-DQA1
3T cell costimulationGO:0312959.1HLA-DQA2, HLA-DQA1
4T cell receptor signaling pathwayGO:0508528.9HLA-DQA1, HLA-DQA2
5cytokine-mediated signaling pathwayGO:0192218.8HLA-DQA1, HLA-DQA2, IFIT3

Molecular functions related to Childhood Type Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.2HLA-DQA1, HLA-DQA2

Products for genes affiliated with Childhood Type Dermatomyositis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Childhood Type Dermatomyositis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet