Aliases & Classifications for Chlamydia

Summaries for Chlamydia

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to hepatitis and artery disease, and has symptoms including fever, pelvic pain and pruritus. An important gene associated with Chlamydia is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cellular

CDC : 3 Women under 25 and older women with risk factors need testing every year.

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 546)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.0 IFNG IL10 IL6 TNF
2 artery disease 30.0 CD40LG CD79A CRP
3 peripheral artery disease 29.7 IL10 TLR2 TNF
4 cholera 29.5 CD79A IL1B IL6
5 rosacea 29.5 IFNG IL10 IL1B
6 uveitis 29.4 CD40LG CD79A TNF
7 neuropathy 29.4 CRP CXCL8 IL1B IL6 TLR4 TNF
8 tuberculosis 29.3 CD40LG IL10 IL1B IL6 TNF
9 nasopharyngitis 29.0 CD79A CXCL8 IFNG IL1B IL6 TNF
10 choroiditis 29.0 CRP CXCL8 IL10 IL1B IL6 TLR4
11 acute chest syndrome 28.6 CD40LG CD79A CRP CXCL8 IFNG IL10
12 ornithosis 11.8
13 trachoma 11.5
14 inclusion conjunctivitis 11.3
15 lymphogranuloma venereum 11.3
16 reactive arthritis 11.1
17 pelvic inflammatory disease 11.1
18 proctitis 11.1
19 ophthalmia neonatorum 11.1
20 fitz-hugh-curtis syndrome 11.1
21 pseudomembranous conjunctivitis 10.7
22 pneumonia 10.6
23 intussusception 10.4 IL1B TNF
24 pyridoxal 5'-phosphate-dependent epilepsy 10.4 IL10 TNF
25 hidradenitis suppurativa 10.4 CXCL8 HSPD1 IL10
26 conidiobolomycosis 10.3 CXCL8 IL10 TNF
27 thymic neuroendocrine carcinoma 10.3 CXCL8 IL6 TNF
28 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IFNG IL10 TNF
29 neonatal hypoxic and ischemic brain injury 10.3 CXCL8 IL10 IL6
30 handl syndrome 10.3 CXCL8 TLR2 TNF
31 transient tic disorder 10.3 IL10 IL6 TNF
32 glucose intolerance 10.3 CXCL8 IFNG TNF
33 coronary arterial fistulas 10.3 CXCL8 IL10 TLR4
34 stocco dos santos syndrome 10.3 IFNG IL1B TNF
35 ulcerative proctitis 10.3 CXCL8 TLR2 TNF
36 oculomotor nerve paralysis 10.3 CXCL8 IL1B IL6
37 common peroneal nerve lesion 10.3 CXCL8 IL1B IL6
38 mycoplasmal pneumonia 10.3 CXCL8 TLR2 TNF
39 neurotic disorder 10.3 IFNG IL10 TNF
40 lepromatous leprosy 10.3 IFNG IL10 IL6
41 urethritis 10.3
42 unilateral multicystic dysplastic kidney 10.3 CRP IL6 TNF
43 anal paget's disease 10.3 IL1B IL6 TNF
44 orthostatic proteinuria 10.3 CXCL8 IL6 TNF
45 immunodeficiency due to a late component of complement deficiency 10.3 CXCL8 IFNG IL10
46 primary ciliary dyskinesia 10.3 IL10 IL6 TNF
47 bipolar i disorder 10.3 IL1B IL6 TNF
48 acute myeloid leukemia with recurrent genetic anomaly 10.3 IFNG IL10 TNF
49 swine influenza 10.3 CRP IL6 TNF
50 tinea capitis 10.3 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pelvic pain, pruritus

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 NOS2 CD40LG RAF1 CXCL8 TNF IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 CD40LG RAF1 CXCL8 TNF IL10 IL1B
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.49 CASP1 CD40LG CD79A HSPD1 IDO1 IFNG
2 cardiovascular system MP:0005385 10.47 TLR2 TLR4 TNF CASP1 CD40LG CRP
3 homeostasis/metabolism MP:0005376 10.45 CASP1 CD40LG CD79A CRP IDO1 IFNG
4 hematopoietic system MP:0005397 10.44 IL10 IL1B IL6 MAPK14 MCL1 NOS2
5 immune system MP:0005387 10.44 CASP1 CD40LG CD79A CRP IDO1 IFNG
6 integument MP:0010771 10.37 MCL1 NECTIN1 NOS2 RAC1 RAF1 TLR2
7 mortality/aging MP:0010768 10.36 MAPK14 MCL1 NECTIN1 NOS2 RAC1 RAF1
8 behavior/neurological MP:0005386 10.34 HSPD1 IFNG IL10 IL6 MAPK14 NECTIN1
9 endocrine/exocrine gland MP:0005379 10.34 CASP1 CD40LG IFNG IL10 IL6 MAPK14
10 growth/size/body region MP:0005378 10.33 HSPD1 TLR4 TNF IFNG IL10 IL6
11 nervous system MP:0003631 10.24 CASP1 CD40LG CD79A HSPD1 IFNG IL10
12 muscle MP:0005369 10.21 IDO1 IFNG IL10 IL6 MAPK14 NOS2
13 liver/biliary system MP:0005370 10.18 IFNG IL10 IL6 MAPK14 NOS2 RAF1
14 neoplasm MP:0002006 10.18 IL1B IL6 MAPK14 NOS2 RAF1 TLR2
15 digestive/alimentary MP:0005381 10.17 CASP1 IFNG IL10 IL6 NOS2 TLR2
16 craniofacial MP:0005382 10.12 IFNG IL10 NECTIN1 NOS2 RAC1 RAF1
17 reproductive system MP:0005389 10.07 CASP1 CD40LG HSPD1 IDO1 IFNG IL10
18 renal/urinary system MP:0005367 9.97 TLR4 CASP1 CD40LG CD79A IDO1 IFNG
19 respiratory system MP:0005388 9.81 IFNG IL10 IL6 MAPK14 NOS2 RAF1
20 skeleton MP:0005390 9.7 CD40LG IFNG IL10 IL1B IL6 MAPK14
21 vision/eye MP:0005391 9.23 IFNG IL10 IL6 NECTIN1 NOS2 RAF1

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 165)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 564-25-0 54671203
3
Lymecycline Approved Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
5
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
6
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
7
Cefixime Approved Phase 4,Phase 3 79350-37-1 54362 5362065
8
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
11
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
12
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
13
Menthol Approved Phase 4 2216-51-5 16666
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
18 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
19 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
20 Anti-HIV Agents Phase 4
21 Anti-Retroviral Agents Phase 4
22 Antiviral Agents Phase 4,Phase 3
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
25 Reverse Transcriptase Inhibitors Phase 4
26 Antitubercular Agents Phase 4,Phase 3,Phase 2
27 Contraceptive Agents Phase 4,Phase 3,Phase 2
28 Contraceptives, Oral Phase 4
29 Anthelmintics Phase 4,Phase 3
30 Antimitotic Agents Phase 4
31 Contraceptives, Oral, Combined Phase 4
32
Medroxyprogesterone Phase 4 520-85-4 10631
33 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
35 Contraceptive Agents, Male Phase 4
36 Carboxymethylcellulose Sodium Phase 4,Phase 2
37 Cathartics Phase 4,Phase 2
38 Laxatives Phase 4,Phase 2
39
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
40
Rifampin Approved Phase 3,Phase 2 13292-46-1 5458213 5381226
41
Erythromycin Approved, Vet_approved Phase 3,Phase 2 114-07-8 12560
42
Metronidazole Approved Phase 3 443-48-1 4173
43
Clarithromycin Approved Phase 3 81103-11-9 84029
44
Ethanol Approved Phase 3,Phase 1,Phase 2 64-17-5 702
45
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
46
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
47
Sulfadoxine Approved Phase 3 2447-57-6 17134
48
Iron Approved Phase 3 7439-89-6 23925
49
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
50
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743

Interventional clinical trials:

(show top 50) (show all 217)
id Name Status NCT ID Phase
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
2 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
3 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4
4 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
5 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4
6 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4
7 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4
8 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
9 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4
10 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4
11 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4
12 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
13 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4
14 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
15 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
16 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
17 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4
18 Expanded PrEP Implementation in Communities in NSW Recruiting NCT02870790 Phase 4
19 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4
20 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4
21 Water Uptake for Health in Amhara Pilot Active, not recruiting NCT02373657 Phase 4
22 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Active, not recruiting NCT01767506 Phase 4
23 Use of Abbott RealTime CT/NG to Detect Chlamydia Trachomatis [CT] & Neisseria Gonorrhoeae [NG] in Men Who Have Sex With Men [MSM] Terminated NCT01291264 Phase 4
24 Hormonal Contraception and Risk of Chlamydia and Gonorrhea Terminated NCT00091728 Phase 4
25 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4
26 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4
27 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4
28 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3
29 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
30 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
31 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3
32 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
33 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3
34 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3
35 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
36 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3
37 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3
38 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3
39 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3
40 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3
41 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3
42 HIV Prevention for African American Teens Completed NCT00279799 Phase 3
43 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3
44 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
45 HIV and STD Prevention for High-Risk, Inner-City, African American Youth Completed NCT00353405 Phase 3
46 A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom Completed NCT01223313 Phase 3
47 Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea Completed NCT01136850 Phase 3
48 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
49 Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth Completed NCT00131235 Phase 3
50 Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS) Completed NCT01239693 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

39
Testes, Endothelial, T Cells, Smooth Muscle, Monocytes, Prostate, Heart

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 1301)
id Title Authors Year
1
Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining. ( 28074107 )
2017
2
Analysis of laboratory testing results for Chlamydia trachomatis infection in an STI clinic in India: Need for extragenital screening. ( 28088589 )
2017
3
Impact of rectal gonorrhoea and chlamydia on HIV viral load in the rectum: potential significance for onward transmission. ( 28081680 )
2017
4
Comparative study in infertile couples with and without Chlamydia trachomatis genital infection. ( 28086915 )
2017
5
Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides. ( 28526018 )
2017
6
Chlamydia trachomatis-induced Fitz-Hugh-Curtis syndrome: a case report. ( 28057084 )
2017
7
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
8
Concordance of chlamydia infections of the rectum and urethra in same-sex male partnerships: a cross-sectional analysis. ( 28056825 )
2017
9
Perceived Patient Preference and Clinical Testing for Chlamydia and Gonorrhea in Females. ( 28081613 )
2017
10
Genital and Extragenital Gonorrhea and Chlamydia in Children and Adolescents Evaluated for Sexual Abuse. ( 28072668 )
2017
11
Topical tenofovir protects against vaginal SHIV infection in macaques co-infected with chlamydia trachomatis and trichomonas vaginalis. ( 28060011 )
2017
12
Comparison of self-collected meatal swabs with urine specimens for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in men. ( 28068218 )
2017
13
Proportion of Tubal Factor Infertility due to Chlamydia: Finite Mixture Modeling of Serum Antibody Titers. ( 28062393 )
2017
14
Clinical characteristics of genital chlamydia infection in pelvic inflammatory disease. ( 28086838 )
2017
15
Gonorrhea and chlamydia in the emergency department: Continued need for more focused treatment for men, women and pregnant women. ( 28073612 )
2017
16
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
17
Evidence for a Di-A/-oxo Diamond Core in the Mn(IV)/Fe(IV) Activation Intermediate of Ribonucleotide Reductase from Chlamydia trachomatis. ( 28075562 )
2017
18
The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. ( 28041929 )
2017
19
Treatment efficacy of azithromycin 1A g single dose versus doxycycline 100A mg twice daily for 7A days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. ( 28061753 )
2017
20
Higher organism load associated with failure of azithromycin to treat rectal chlamydia. ( 27180823 )
2016
21
Population-Based Study of Prediagnostic Antibodies to Chlamydia trachomatis in Relation to Adverse Pregnancy Outcome. ( 27196260 )
2016
22
The L2b real-time PCR targeting the pmpH gene of Chlamydia trachomatis used for the diagnosis of lymphogranuloma venereum is not specific to L2b strains. ( 27040805 )
2016
23
Population attributable fraction of pelvic inflammatory disease associated with chlamydia and gonorrhoea: a cross-sectional analysis of Australian sexual health clinic data. ( 27091729 )
2016
24
Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )
2016
25
Screening for genital chlamydia infection. ( 27623210 )
2016
26
Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF. ( 27436813 )
2016
27
Analysis of the Humoral Immune Response against Surface and Virulence-Associated Chlamydia abortus Proteins in Ovine and Human Abortion Using a Newly Developed Line Immunoassay. ( 27194684 )
2016
28
Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth. ( 26381674 )
2016
29
Targeted Disruption of Chlamydia trachomatis Invasion by in Trans Expression of Dominant Negative Tarp Effectors. ( 27602332 )
2016
30
Association between treatment for gonorrhoea and chlamydia and lower condom use in a cross-sectional study of female sex workers in southern India. ( 27194314 )
2016
31
The Chlamydia trachomatis Ctad1 invasin exploits the human integrin I^1 receptor for host cell entry. ( 26597572 )
2016
32
Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. ( 27227411 )
2016
33
Comparison of Workflow, Maintenance, and Consumables in the GeneXpert Infinity 80 and Panther Instruments While Testing for Chlamydia trachomatis and Neisseria gonorrhoeae. ( 27196259 )
2016
34
Manipulation of the Host Cell Cytoskeleton by Chlamydia. ( 27197645 )
2016
35
Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse. ( 26766527 )
2016
36
Characteristics Associated With Urethral and Rectal Gonorrhea and Chlamydia Diagnoses in a US National Sample of Gay and Bisexual Men: Results From the One Thousand Strong Panel. ( 26859803 )
2016
37
Low Prevalence of Conjunctival Infection with Chlamydia trachomatis in a Treatment-NaA^ve Trachoma-Endemic Region of the Solomon Islands. ( 27603015 )
2016
38
Can Chlamydia abortus be transmitted by embryo transfer in goats? ( 27341774 )
2016
39
Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells. ( 27134121 )
2016
40
One Face of Chlamydia trachomatis: The Infectious Elementary Body. ( 27197644 )
2016
41
Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. ( 26888658 )
2016
42
Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )
2016
43
The presence of Chlamydia phage PhiCPG1 capsid protein VP1 genes and antibodies in patients infected with Chlamydia trachomatis. ( 27213552 )
2016
44
Brief report: Associations between antecedent bacterial vaginosis and incident chlamydia and gonorrhea diagnoses, U.S. Army females, 2006-2012. ( 26930150 )
2016
45
Study of the prevalence and association of ocular chlamydial conjunctivitis in women with genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans attending outpatient clinic. ( 27588273 )
2016
46
Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages. ( 26912299 )
2016
47
Assessing Trends in Chlamydia Positivity and Gonorrhea Incidence and Their Associations With the Incidence of Pelvic Inflammatory Disease and Ectopic Pregnancy in Washington State, 1988-2010. ( 26656441 )
2016
48
Severe Proctitis Caused by Chlamydia trachomatis Serovars D. ( 27803429 )
2016
49
Erratum: prevalence of plasmid-bearing and plasmid-free chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia. ( 27215275 )
2016
50
Clinical, diagnostic and pathologic features of presumptive cases of Chlamydia pecorum-associated arthritis in Australian sheep flocks. ( 27608808 )
2016

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 CASP1 CD40LG CD79A CRP CXCL8 IFNG
2
Show member pathways
13.81 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
3
Show member pathways
13.66 CXCL8 IFNG IL10 IL1B IL6 MAPK14
4
Show member pathways
13.58 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
5
Show member pathways
13.54 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
6
Show member pathways
13.44 CASP1 CD40LG CXCL8 IL10 IL1B IL6
7
Show member pathways
13.36 CD79A IFNG IL1B MAPK14 RAC1 RAF1
8
Show member pathways
13.16 CASP1 CXCL8 IL1B IL6 MAPK14 NOS2
9
Show member pathways
13.04 MAPK14 NECTIN1 NOS2 RAC1 RAF1 TNF
10
Show member pathways
13.04 CD40LG CXCL8 HSPD1 IFNG IL10 IL1B
11
Show member pathways
13.01 CASP1 CD79A MAPK14 RAC1 RAF1 TNF
12
Show member pathways
13.01 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
13
Show member pathways
12.96 CXCL8 IFNG IL10 IL1B IL6 MAPK14
14
Show member pathways
12.9 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
15
Show member pathways
12.89 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
16 12.85 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
17
Show member pathways
12.84 CD40LG IL1B IL6 TLR2 TLR4 TNF
18
Show member pathways
12.81 CD40LG IFNG IL1B MAPK14 RAF1 TNF
19
Show member pathways
12.81 CD40LG CD79A IFNG IL10 RAC1 RAF1
20
Show member pathways
12.8 CASP1 CD40LG IL1B MAPK14 RAC1 RAF1
21
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 NOS2
22
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 MCL1
23 12.77 CXCL8 IL6 NOS2 RAC1 RAF1
24 12.75 IL6 MCL1 RAC1 RAF1 TLR2 TLR4
25 12.73 CD40LG CD79A IDO1 IFNG IL10 IL1B
26
Show member pathways
12.7 CD79A MAPK14 RAC1 RAF1 TNF
27
Show member pathways
12.62 CD40LG IFNG IL10 IL1B IL6 MAPK14
28
Show member pathways
12.61 IL1B MAPK14 NOS2 RAC1 RAF1
29
Show member pathways
12.54 CXCL8 IFNG IL1B IL6 MAPK14 TLR2
30
Show member pathways
12.49 CXCL8 MAPK14 NOS2 RAC1 RAF1
31 12.49 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
32
Show member pathways
12.47 CRP IFNG IL1B IL6 TNF
33
Show member pathways
12.45 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
34
Show member pathways
12.42 MAPK14 RAF1 TLR2 TLR4
35
Show member pathways
12.41 CXCL8 IL6 TLR2 TLR4 TNF
36
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
37 12.39 IFNG IL6 NOS2 TLR2 TLR4 TNF
38 12.38 CXCL8 HSPD1 IL10 IL1B IL6 TNF
39
Show member pathways
12.37 IFNG IL10 IL6 MCL1 RAF1
40
Show member pathways
12.37 CXCL8 IFNG IL10 IL1B IL6 TNF
41
Show member pathways
12.37 CXCL8 IFNG IL1B IL6 NOS2 TLR2
42
Show member pathways
12.36 CD40LG IFNG IL10 IL1B MAPK14 NOS2
43
Show member pathways
12.28 MAPK14 RAC1 RAF1 TNF
44 12.27 IFNG IL1B MAPK14 RAC1 TNF
45 12.25 HSPD1 IFNG IL10 IL1B IL6 MAPK14
46 12.23 IFNG IL1B MAPK14 RAC1 TNF
47
Show member pathways
12.21 IL10 IL6 MAPK14 RAF1
48
Show member pathways
12.21 IL1B MAPK14 RAF1 TLR2 TLR4
49 12.19 CXCL8 IL10 IL1B IL6 MCL1 NOS2
50 12.18 CXCL8 MAPK14 RAF1 TNF

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 CD40LG CRP CXCL8 HSPD1 IFNG IL10
2 extracellular region GO:0005576 9.7 CASP1 CD40LG CRP CXCL8 IFNG IL10
3 membrane raft GO:0045121 9.67 CD79A HSPD1 TLR2 TNF
4 lipopolysaccharide receptor complex GO:0046696 9.32 HSPD1 TLR4
5 external side of plasma membrane GO:0009897 9.1 CD40LG CD79A IFNG IL6 TLR4 TNF
6 cytoplasm GO:0005737 10.13 CASP1 CD79A HSPD1 IDO1 IFNG IL10

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.99 IL10 IL1B IL6 TNF
2 movement of cell or subcellular component GO:0006928 9.98 CXCL8 IFNG MAPK14 RAC1
3 cellular response to mechanical stimulus GO:0071260 9.97 CASP1 IL1B RAC1 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 CD40LG IL1B IL6 TLR2 TLR4 TNF
5 response to glucocorticoid GO:0051384 9.96 HSPD1 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.96 CRP IL6 TLR2 TNF
7 regulation of insulin secretion GO:0050796 9.95 IFNG IL1B NOS2 TNF
8 positive regulation of T cell proliferation GO:0042102 9.94 CD40LG IFNG IL1B IL6
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.93 IL6 RAF1 TNF
10 response to insulin GO:0032868 9.93 IL10 IL6 TLR2
11 B cell differentiation GO:0030183 9.93 CD40LG CD79A IL10
12 positive regulation of JNK cascade GO:0046330 9.93 IL1B TLR4 TNF
13 neutrophil chemotaxis GO:0030593 9.92 CXCL8 IFNG IL1B
14 positive regulation of inflammatory response GO:0050729 9.92 HSPD1 TLR2 TLR4
15 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
16 defense response to Gram-negative bacterium GO:0050829 9.91 IL6 NOS2 TLR4
17 positive regulation of interferon-gamma production GO:0032729 9.91 HSPD1 IL1B TLR4 TNF
18 positive regulation of tumor necrosis factor production GO:0032760 9.9 IFNG TLR2 TLR4
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.89 IL1B MCL1 TNF
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 HSPD1 TLR2 TLR4
21 positive regulation of cytokine secretion GO:0050715 9.87 CASP1 IL10 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TNF
23 B cell proliferation GO:0042100 9.87 CD40LG CD79A HSPD1 IL10
24 response to bacterium GO:0009617 9.86 CASP1 IL6 NOS2 TLR4
25 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL8 IFNG IL10 IL6 MAPK14 NOS2
26 defense response to protozoan GO:0042832 9.85 IFNG IL10 IL6
27 response to ATP GO:0033198 9.85 CASP1 HSPD1 IL1B
28 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B TLR2 TLR4 TNF
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG IL1B IL6 TLR4 TNF
30 positive regulation of interleukin-10 production GO:0032733 9.84 CD40LG HSPD1 TLR2 TLR4
31 negative regulation of growth of symbiont in host GO:0044130 9.83 IFNG IL10 TNF
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.83 IFNG IL1B TNF
33 positive regulation of NF-kappaB import into nucleus GO:0042346 9.83 IL1B TLR2 TLR4 TNF
34 response to molecule of bacterial origin GO:0002237 9.8 CXCL8 IL10 TLR2
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B MAPK14 TLR2 TLR4 TNF
36 positive regulation of interleukin-6 production GO:0032755 9.8 HSPD1 IL1B IL6 TLR2 TLR4 TNF
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.79 IFNG IL1B TNF
39 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR2 TLR4 TNF
40 negative regulation of lipid storage GO:0010888 9.77 CRP IL6 TNF
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.76 IFNG IL10 TLR4
42 cellular response to lipoteichoic acid GO:0071223 9.75 TLR2 TLR4
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.75 IFNG IL1B
44 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 TLR4 TNF
45 death-inducing signaling complex assembly GO:0071550 9.74 RAF1 TNF
46 endothelial cell apoptotic process GO:0072577 9.74 IL10 TNF
47 regulation of defense response to virus by host GO:0050691 9.74 IFNG IL1B
48 regulation of establishment of endothelial barrier GO:1903140 9.74 IL1B TNF
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.73 IL10 TNF
50 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.73 IFNG TLR4

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virion binding GO:0046790 9.32 CRP NECTIN1
2 cytokine activity GO:0005125 9.17 CD40LG CXCL8 IFNG IL10 IL1B IL6
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.13 HSPD1 TLR2 TLR4
5 protein binding GO:0005515 10.19 CASP1 CD40LG CD79A CRP CXCL8 HSPD1

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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48 NDF-RT
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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