Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 72 3 14
Chlamydial Infection 12 51
Chlamydia Trachomatis Infectious Disease 12
Chlamydia Infections 69
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 32 A56.2 A74.9
UMLS 69 C0008149

Summaries for Chlamydia

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to trachoma and pelvic inflammatory disease, and has symptoms including pruritus, pelvic pain and fever. An important gene associated with Chlamydia is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Women under 25 and older women with risk factors need testing every year.

Wikipedia : 72 Chlamydia infection, often simply known as chlamydia, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)
# Related Disease Score Top Affiliating Genes
1 trachoma 33.0 HSPD1 IDO1 IL10 TNF
2 pelvic inflammatory disease 31.8 CD40LG CRP HSPD1 TLR2 TLR4
3 reactive arthritis 31.5 CD79A CRP HSPD1 IFNG IL10 IL6
4 conjunctivitis 31.1 CXCL8 IFNG IL6
5 urethritis 30.8 CD40LG CD79A HSPD1
6 vaginitis 30.8 CXCL8 IL1B IL6
7 endometritis 30.8 IL1B IL6 TNF
8 arthritis 30.7 CXCL8 IFNG IL10 IL1B IL6 TNF
9 salpingitis 30.7 CD40LG CD79A HSPD1
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.5 HSPD1 IFNG IL10
11 arteries, anomalies of 30.5 CRP IL1B IL6 TNF
12 prostatitis 30.4 CXCL8 IL10 IL1B IL6 TNF
13 pharyngitis 30.4 CRP CXCL8 IL1B
14 ischemic heart disease 30.2 CRP IL6 TNF
15 spondyloarthropathy 30.1 IFNG IL10 IL6 TNF
16 hepatitis b 30.1 IFNG TLR2 TLR4 TNF
17 arteriosclerosis 30.1 CRP HSPD1 IL10 IL6
18 keratoconjunctivitis 30.1 CD79A CXCL8 IFNG TNF
19 mycobacterium chelonae 30.1 CXCL8 TLR2
20 chronic follicular conjunctivitis 30.1 CD79A IL1B
21 vulvovaginitis 30.0 CXCL8 HSPD1 IL10
22 acute transverse myelitis 30.0 CXCL8 IL10 IL6
23 acute salpingitis 30.0 CD40LG CD79A MCL1 TNF
24 keratitis, hereditary 30.0 IL1B TLR2 TLR4
25 poliomyelitis 30.0 IFNG IL10 TNF
26 pneumonia 30.0 CD40LG CRP CXCL8 IL10 IL1B IL6
27 rosacea 29.9 IL6 TLR2 TNF
28 avian influenza 29.9 CXCL8 IL6 TNF
29 campylobacteriosis 29.9 IFNG IL1B TLR4
30 rubella 29.9 CD40LG IL10 TNF
31 temporal arteritis 29.9 CD40LG CRP IFNG IL6
32 tympanosclerosis 29.9 NOS2 TLR4 TNF
33 neuritis 29.8 IFNG IL1B TNF
34 cytomegalovirus infection 29.8 CXCL8 IFNG IL10 IL6 TNF
35 transverse myelitis 29.8 CXCL8 IL10 IL6 TNF
36 adult respiratory distress syndrome 29.8 CXCL8 IL10 IL6 TNF
37 hemophagocytic lymphohistiocytosis 29.8 CXCL8 IFNG IL10 TNF
38 relapsing-remitting multiple sclerosis 29.8 IFNG IL10 IL6 TNF
39 coronary stenosis 29.7 CRP IL6 TLR4
40 lymphoma, mucosa-associated lymphoid type 29.7 CD40LG CD79A HSPD1
41 listeriosis 29.7 IDO1 IL10 IL6 TNF
42 respiratory failure 29.7 CRP CXCL8 IL10 TNF
43 erythema multiforme 29.7 CD79A IFNG TNF
44 cat-scratch disease 29.7 CD40LG HSPD1 IFNG
45 bacterial vaginosis 29.7 CXCL8 IL10 IL1B IL6 TLR2 TLR4
46 tonsillitis 29.6 CD79A CXCL8 IFNG IL1B IL6 TNF
47 bronchiolitis obliterans 29.6 CXCL8 IFNG IL10 IL6 TNF
48 mycobacterium tuberculosis 1 29.6 HSPD1 IFNG IL10 TLR2 TLR4 TNF
49 central nervous system disease 29.5 IFNG IL1B NOS2 TNF
50 gingivitis 29.5 CD79A CXCL8 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


pruritus, pelvic pain, fever

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 MCL1 NOS2 RAF1 TNF CASP1 CD40LG
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 MCL1 NOS2 RAF1 TNF CASP1 CD40LG
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.48 CASP1 CD40LG CD79A HSPD1 IDO1 IFNG
2 cardiovascular system MP:0005385 10.46 TLR4 TNF CD40LG CRP IDO1 IFNG
3 hematopoietic system MP:0005397 10.43 TLR2 TLR4 TNF CASP1 CD40LG CD79A
4 immune system MP:0005387 10.42 CRP IDO1 IFNG IL10 IL1B IL6
5 homeostasis/metabolism MP:0005376 10.41 IL1B IL6 MAPK14 NOS2 RAC1 RAF1
6 endocrine/exocrine gland MP:0005379 10.33 RAF1 TLR2 TNF CASP1 CD40LG IFNG
7 integument MP:0010771 10.32 CASP1 CD40LG IFNG IL10 IL1B IL6
8 growth/size/body region MP:0005378 10.31 IFNG IL10 IL1B HSPD1 IL6 MAPK14
9 mortality/aging MP:0010768 10.31 CASP1 CD40LG HSPD1 IFNG IL10 IL1B
10 nervous system MP:0003631 10.2 CASP1 CD40LG CD79A HSPD1 IFNG IL10
11 muscle MP:0005369 10.18 TLR4 TNF HSPD1 IDO1 IFNG IL10
12 digestive/alimentary MP:0005381 10.16 CASP1 IFNG IL10 IL6 NOS2 TLR2
13 liver/biliary system MP:0005370 10.16 CD79A IFNG IL10 IL6 MAPK14 NOS2
14 neoplasm MP:0002006 10.15 CASP1 CD79A IFNG IL10 IL1B IL6
15 craniofacial MP:0005382 10.11 IFNG IL10 IL1B NOS2 RAC1 RAF1
16 reproductive system MP:0005389 9.97 CASP1 CD40LG RAC1 HSPD1 TLR4 IDO1
17 renal/urinary system MP:0005367 9.91 CASP1 CD40LG CD79A IDO1 IFNG IL6
18 respiratory system MP:0005388 9.61 IFNG IL10 IL6 MAPK14 NOS2 RAF1
19 skeleton MP:0005390 9.36 TNF CD40LG IFNG IL10 IL1B IL6

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 53477736 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
5
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
6
Cefixime Approved, Investigational Phase 4,Phase 3 79350-37-1 5362065 54362
7
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
10
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 114-07-8 12560
11
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
12
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
13
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 46936176 6474909
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
18 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
19 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
20 Anti-HIV Agents Phase 4,Phase 3,Phase 2
21 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2
22 Antiviral Agents Phase 4,Phase 3,Phase 2
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
25 Reverse Transcriptase Inhibitors Phase 4,Phase 3
26
Tenofovir Phase 4,Phase 3,Phase 2 147127-20-6 464205
27 Antitubercular Agents Phase 4,Phase 3,Phase 2
28 Contraceptive Agents Phase 4,Phase 3
29 Contraceptives, Oral Phase 4
30 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
32 Erythromycin Estolate Phase 4,Phase 3,Phase 2
33 Erythromycin Ethylsuccinate Phase 4,Phase 3,Phase 2
34 Erythromycin stearate Phase 4,Phase 3,Phase 2
35 Anthelmintics Phase 4,Phase 3
36 Antimitotic Agents Phase 4
37 Contraceptives, Oral, Combined Phase 4
38
Medroxyprogesterone Phase 4 520-85-4 10631
39 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
41 Contraceptive Agents, Male Phase 4
42 Carboxymethylcellulose Sodium Phase 4,Phase 2
43 Cathartics Phase 4,Phase 2
44 Laxatives Phase 4,Phase 2
45
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
46
Rifampin Approved Phase 3,Phase 2 13292-46-1 5381226 5458213
47
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
48 silver nitrate Approved, Investigational Phase 3
49
Metronidazole Approved Phase 3 443-48-1 4173
50
Ethanol Approved Phase 3,Phase 1,Phase 2 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 246)

# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
3 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
4 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
5 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
6 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
7 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
8 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
9 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
10 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
11 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
12 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
13 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
14 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
15 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
16 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
17 Mortality Reduction After Oral Azithromycin: Morbidity Study Completed NCT02048007 Phase 4 Azithromycin;Placebo
18 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
19 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
20 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
21 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
22 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
23 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
24 Use of Abbott RealTime CT/NG to Detect Chlamydia Trachomatis [CT] & Neisseria Gonorrhoeae [NG] in Men Who Have Sex With Men [MSM] Terminated NCT01291264 Phase 4
25 Hormonal Contraception and Risk of Chlamydia and Gonorrhea Terminated NCT00091728 Phase 4 Depo Medroxyprogesterone acetate;Combined oral contraceptives
26 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
27 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
28 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
29 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
30 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
31 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
32 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3 Ophthalmic gel (placebo);Ganciclovir
33 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
34 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
35 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
36 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
37 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
38 Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
39 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
40 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
41 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
42 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
43 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
44 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
45 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
46 HIV Prevention for African American Teens Completed NCT00279799 Phase 3
47 HIV and STD Prevention for High-Risk, Inner-City, African American Youth Completed NCT00353405 Phase 3
48 A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom Completed NCT01223313 Phase 3
49 Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea Completed NCT01136850 Phase 3 chloroquine, sulphadoxine pyrimethamine, LLIN;azithromycin, sulphadoxine pyrimethamine, LLIN
50 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

38
Testes, Eye, Endothelial, T Cells, Prostate, Heart, Smooth Muscle

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 1471)
# Title Authors Year
1
Prevalence of<i>Chlamydia trachomatis</i>-Specific Antibodies before and after Mass Drug Administration for Trachoma in Community-Wide Surveys of Four Communities in Nepal. ( 29141720 )
2018
2
Chlamydia trachomatis genotypes A and B from urogenital specimens of patients in Spain: an organotropism-related gene and multilocus sequence typing study. ( 29427803 )
2018
3
Screening for Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Men Who Have Sex With Men: Diagnostic Accuracy of Nucleic Acid Amplification Test on Pooled Urine, Anorectal, and Pharyngeal Specimens. ( 29419710 )
2018
4
A preliminary survey of Chlamydia psittaci genotypes from native and introduced birds in New Zealand. ( 29447087 )
2018
5
Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort. ( 29293503 )
2018
6
Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-based Fusion Antigen CTH522 into Protein Nanoparticles. ( 29452143 )
2018
7
Chlamydia trachomatis and Adverse Pregnancy Outcomes: Meta-analysis of Patients With and Without Infection. ( 29417367 )
2018
8
Transformation of Chlamydia: Current approaches and impact on our understanding of chlamydial infection biology. ( 29409975 )
2018
9
Preparing for the Chlamydia and Gonorrhea Self-Test. ( 29420452 )
2018
10
Racial/ethnic disparities in the lifetime risk of Chlamydia trachomatis diagnosis and adverse reproductive health outcomes among women in King County, Washington. ( 29420716 )
2018
11
Fitz-Hugh-Curtis syndrome in a man positive for Chlamydia trachomatis. ( 29417387 )
2018
12
Pathology after<i>Chlamydia trachomatis</i>infection is driven by nonprotective immune cells that are distinct from protective populations. ( 29440378 )
2018
13
Risk of Pelvic Inflammatory Disease in Relation to Chlamydia and Gonorrhea Testing, Repeat Testing, and Positivity: A Population-Based Cohort Study. ( 29136127 )
2018
14
An Online Risk Index for the Cross-Sectional Prediction of New HIV Chlamydia, and Gonorrhea Diagnoses Across U.S. Counties and Across Years. ( 29427233 )
2018
15
Barriers and Facilitators of Partner Treatment of Chlamydia: A Qualitative Investigation with Prescribers and Community Pharmacists. ( 29419807 )
2018
16
Rising Chlamydia and Gonorrhoea Incidence and Associated Risk Factors Among Female Sex Workers in Australia: A Retrospective Cohort Study. ( 29420449 )
2018
17
Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs. ( 28930567 )
2018
18
Overfilled urine specimens for gonorrhea and chlamydia testing: Implications for practice. ( 29422146 )
2018
19
Prevalence of Chlamydia Trachomatis, Neisseria Gonorrhoeae, and Trichomonas Vaginalis Infection in Chilean Adolescents and Young Adults. ( 29409759 )
2018
20
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
21
Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. ( 29253201 )
2018
22
Detection of<i>Chlamydia trachomatis</i>in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis. ( 29431148 )
2018
23
Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease. ( 29426279 )
2018
24
Genital<i>Chlamydia trachomatis</i>infections in young adults - a school-based bio-behavioural study in urban areas, Poland, 2012 to 2015. ( 29439753 )
2018
25
Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions. ( 28945814 )
2017
26
Gonorrhea and chlamydia in the emergency department: Continued need for more focused treatment for men, women and pregnant women. ( 28073612 )
2017
27
Monitoring therapy success of urogenital Chlamydia trachomatis infections in women: A prospective observational cohort study. ( 28934342 )
2017
28
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria. ( 29110020 )
2017
29
Concordance of chlamydia infections of the rectum and urethra in same-sex male partnerships: a cross-sectional analysis. ( 28056825 )
2017
30
Analysis of laboratory testing results for Chlamydia trachomatis infection in an STI clinic in India: Need for extragenital screening. ( 28088589 )
2017
31
Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women. ( 28949051 )
2017
32
Follicular Conjunctivitis due to Chlamydia felis-Case Report, Review of the Literature and Improved Molecular Diagnostics. ( 28770201 )
2017
33
Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. ( 28951853 )
2017
34
Reduced-cost Chlamydia trachomatis-specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes. ( 28487054 )
2017
35
Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides. ( 28526018 )
2017
36
Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis. ( 28946931 )
2017
37
Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining. ( 28074107 )
2017
38
<i>Chlamydia trachomatis</i> versus common uropathogens as a cause of chronic bacterial prostatitis: Is there any difference? Results of a prospective parallel-cohort study. ( 29124247 )
2017
39
Authors'reply: Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe. ( 28449737 )
2017
40
Chlamydia trachomatis-induced Fitz-Hugh-Curtis syndrome: a case report. ( 28057084 )
2017
41
Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati. ( 28898240 )
2017
42
Neonates Born to Chlamydia-Positive Mothers. ( 28929792 )
2017
43
Detailed molecular epidemiology of Chlamydia trachomatis in the population of Southampton attending the genitourinary medicine clinic in 2012-13 reveals the presence of long established genotypes and transitory sexual networks. ( 28945766 )
2017
44
Fluorescence-Reported Allelic Exchange Mutagenesis Reveals a Role for Chlamydia trachomatis TmeA in Invasion That Is Independent of Host AHNAK. ( 28970272 )
2017
45
Severe Sepsis and Acute Myocardial Dysfunction in an Adolescent with Chlamydia Trachomatis Pelvic Inflammatory Disease: A Case Report. ( 29037929 )
2017
46
Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: a case-control study. ( 28947665 )
2017
47
Distribution of Chlamydia Trachomatis Genotypes in Infective Diseases of the Female Lower Genital Tract. ( 28918430 )
2017
48
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
49
Treatment efficacy of azithromycin 1A g single dose versus doxycycline 100A mg twice daily for 7A days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. ( 28061753 )
2017
50
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CASP1 CD40LG CD79A CRP CXCL8 IFNG
2
Show member pathways
13.95 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
3
Show member pathways
13.82 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
4
Show member pathways
13.67 CXCL8 IFNG IL10 IL1B IL6 MAPK14
5
Show member pathways
13.58 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
6
Show member pathways
13.54 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
7
Show member pathways
13.43 CASP1 CD40LG CXCL8 IL10 IL1B IL6
8
Show member pathways
13.37 CD79A IFNG IL1B MAPK14 RAC1 RAF1
9
Show member pathways
13.15 CASP1 CXCL8 IL1B IL6 MAPK14 NOS2
10
Show member pathways
13.11 IL6 MCL1 RAC1 RAF1 TLR2 TLR4
11
Show member pathways
13.04 MAPK14 NOS2 RAB14 RAC1 RAF1 TNF
12
Show member pathways
13.03 CD40LG CXCL8 HSPD1 IFNG IL10 IL1B
13
Show member pathways
13.02 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
14
Show member pathways
13 CASP1 CD79A MAPK14 RAC1 RAF1 TNF
15 12.97 CXCL8 IFNG IL6 NOS2 RAC1 RAF1
16
Show member pathways
12.97 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
17 12.9 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
18
Show member pathways
12.9 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
19
Show member pathways
12.84 CD40LG IL1B IL6 TLR2 TLR4 TNF
20
Show member pathways
12.82 CD40LG CD79A IFNG IL10 RAC1 RAF1
21
Show member pathways
12.81 CD40LG IFNG IL1B MAPK14 RAF1 TNF
22
Show member pathways
12.8 CASP1 CD40LG IL1B MAPK14 RAC1 RAF1
23
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 NOS2
24
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 MCL1
25
Show member pathways
12.77 CXCL8 IL6 MAPK14 RAC1 RAF1 TLR2
26 12.76 CD40LG CD79A IDO1 IFNG IL10 IL1B
27
Show member pathways
12.71 CD79A MAPK14 RAC1 RAF1 TNF
28
Show member pathways
12.63 CXCL8 IFNG IL10 IL1B IL6 MAPK14
29
Show member pathways
12.62 IL1B MAPK14 NOS2 RAC1 RAF1
30
Show member pathways
12.62 CD40LG IFNG IL10 IL1B IL6 MAPK14
31
Show member pathways
12.54 CXCL8 IFNG IL1B IL6 MAPK14 TLR2
32
Show member pathways
12.51 IFNG IL10 IL6 MCL1 RAF1
33
Show member pathways
12.49 CXCL8 MAPK14 NOS2 RAC1 RAF1
34 12.49 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
35
Show member pathways
12.48 CRP IFNG IL1B IL6 TNF
36
Show member pathways
12.44 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
37
Show member pathways
12.43 MAPK14 RAF1 TLR2 TLR4
38
Show member pathways
12.42 CXCL8 IL6 TLR2 TLR4 TNF
39
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
40 12.39 IFNG IL6 NOS2 TLR2 TLR4 TNF
41 12.38 CXCL8 HSPD1 IL10 IL1B IL6 TNF
42
Show member pathways
12.37 CASP1 IFNG IL1B TLR4 TNF
43
Show member pathways
12.37 CXCL8 IFNG IL10 IL1B IL6 TNF
44
Show member pathways
12.36 CXCL8 IFNG IL1B IL6 NOS2 TLR2
45
Show member pathways
12.36 CD40LG IFNG IL10 IL1B MAPK14 NOS2
46 12.35 CASP1 CD40LG MCL1 TNF
47 12.31 HSPD1 IFNG IL10 IL1B IL6 MAPK14
48 12.29 CXCL8 IL6 MAPK14 RAF1
49
Show member pathways
12.28 MAPK14 RAC1 RAF1 TNF
50 12.27 IFNG IL1B MAPK14 RAC1 TNF

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 CASP1 CD40LG CRP CXCL8 IFNG IL10
2 extracellular space GO:0005615 9.61 CD40LG CRP CXCL8 HSPD1 IFNG IL10
3 intracellular GO:0005622 9.32 CD40LG CXCL8 IFNG MAPK14 NOS2 RAB14
4 lipopolysaccharide receptor complex GO:0046696 9.26 HSPD1 TLR4

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.98 CD40LG IL6 RAC1 RAF1
2 activation of MAPK activity GO:0000187 9.98 IL1B MAPK14 TLR4 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.97 IL10 IL1B IL6 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.96 CRP IL6 TLR2 TNF
5 movement of cell or subcellular component GO:0006928 9.94 CXCL8 IFNG MAPK14 RAC1
6 cellular response to mechanical stimulus GO:0071260 9.93 CASP1 IL1B RAC1 TLR4
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 CD40LG IL1B IL6 TLR2 TLR4 TNF
8 regulation of insulin secretion GO:0050796 9.92 IFNG IL1B NOS2 TNF
9 regulation of inflammatory response GO:0050727 9.91 CASP1 TLR4 TNF
10 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR4 TNF
11 B cell differentiation GO:0030183 9.91 CD40LG CD79A IL10
12 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
13 positive regulation of T cell proliferation GO:0042102 9.9 CD40LG IL1B IL6
14 humoral immune response GO:0006959 9.9 IFNG IL6 TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 IL1B MCL1 TNF
16 positive regulation of interferon-gamma production GO:0032729 9.87 HSPD1 IL1B TLR4 TNF
17 response to bacterium GO:0009617 9.86 CASP1 NOS2 TLR4
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.86 HSPD1 TLR2 TLR4
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IFNG IL1B TLR4 TNF
20 response to lipopolysaccharide GO:0032496 9.86 CASP1 IDO1 IL10 IL1B MAPK14 NOS2
21 positive regulation of cytokine secretion GO:0050715 9.85 CASP1 IL10 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TNF
23 B cell proliferation GO:0042100 9.85 CD40LG CD79A HSPD1 IL10
24 positive regulation of interleukin-8 production GO:0032757 9.84 IL1B TLR2 TLR4 TNF
25 positive regulation of interleukin-10 production GO:0032733 9.83 CD40LG HSPD1 TLR2 TLR4
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.81 IL1B TLR2 TLR4 TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 IFNG IL1B TNF
28 positive regulation of macrophage activation GO:0043032 9.8 HSPD1 IL10 TLR4
29 positive regulation of chemokine production GO:0032722 9.8 IL6 TLR2 TLR4 TNF
30 positive regulation of interleukin-6 production GO:0032755 9.8 HSPD1 IL1B IL6 TLR2 TLR4 TNF
31 response to molecule of bacterial origin GO:0002237 9.78 CXCL8 IL10 TLR2
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
33 cellular response to lipoteichoic acid GO:0071223 9.77 MAPK14 TLR2 TLR4
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B MAPK14 TLR2 TLR4 TNF
35 negative regulation of lipid storage GO:0010888 9.76 CRP IL6 TNF
36 cellular response to lipopolysaccharide GO:0071222 9.76 CASP1 CXCL8 IL10 IL6 MAPK14 NOS2
37 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
38 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
39 death-inducing signaling complex assembly GO:0071550 9.73 RAF1 TNF
40 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
41 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 TLR4
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
44 interleukin-1 beta production GO:0032611 9.71 CASP1 IL1B
45 regulation of cytokine production involved in inflammatory response GO:1900015 9.71 MAPK14 NOS2
46 positive regulation of fever generation GO:0031622 9.71 IL1B TNF
47 regulation of immunoglobulin secretion GO:0051023 9.7 CD40LG TNF
48 sequestering of triglyceride GO:0030730 9.7 IL1B TNF
49 positive regulation of killing of cells of other organism GO:0051712 9.7 IFNG NOS2
50 receptor biosynthetic process GO:0032800 9.69 IL10 TNF

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CASP1 CD40LG CD79A CRP CXCL8 HSPD1
2 lipopolysaccharide binding GO:0001530 9.33 HSPD1 TLR2 TLR4
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 cytokine activity GO:0005125 9.17 CD40LG CXCL8 IFNG IL10 IL1B IL6

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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