Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 3 14
Chlamydial Infection 12 52
Chlamydia Trachomatis Infectious Disease 12
Chlamydia Infections 69
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 33 A56.2 A74.9

Summaries for Chlamydia

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to hepatitis b and atherosclerosis, and has symptoms including fever, pelvic pain and pruritus. An important gene associated with Chlamydia is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cellular

CDC : 3 Women under 25 and older women with risk factors need testing every year.

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
id Related Disease Score Top Affiliating Genes
1 hepatitis b 30.5 CXCL8 IFNG IL10 TNF
2 atherosclerosis 30.2 CXCL8 IFNG IL10 IL1B IL6 TNF
3 pityriasis rosea 30.1 IL6 TLR2 TNF
4 myelitis 30.1 IFNG IL10 IL6
5 hemophagocytic lymphohistiocytosis 30.0 IFNG IL10 IL6 TNF
6 alopecia 30.0 CXCL8 IL10 IL6 TNF
7 cholera 29.9 CD79A IL1B IL6
8 uveitis 29.6 CD40LG CD79A TNF
9 choroiditis 29.1 CRP CXCL8 IL10 IL1B IL6 TLR4
10 lymphoma 28.9 CD40LG CD79A IFNG IL10 IL1B IL6
11 asthma 28.6 CD40LG CD79A CXCL8 IFNG IL10 IL1B
12 nasopharyngitis 28.5 CASP1 CD40LG TLR2 TLR4 TNF
13 myocardial infarction 27.4 CASP1 CD40LG CRP IL10 IL1B IL6
14 acute chest syndrome 27.3 CD40LG CD79A CRP CXCL8 IFNG IL10
15 ornithosis 11.8
16 trachoma 11.5
17 inclusion conjunctivitis 11.3
18 lymphogranuloma venereum 11.3
19 reactive arthritis 11.2
20 pelvic inflammatory disease 11.1
21 proctitis 11.1
22 ophthalmia neonatorum 11.1
23 fitz-hugh-curtis syndrome 11.1
24 pure autonomic failure 10.9 IL10 TNF
25 mycobacterium marinum 10.9 CXCL8 HSPD1
26 mycobacterium malmoense 10.9 CXCL8 TLR2
27 acute ackee fruit intoxication 10.9 IL10 TNF
28 smarca4-deficient sarcoma of thorax 10.9 IL6 TNF
29 hidradenitis suppurativa 10.9 CXCL8 HSPD1 IL10
30 basidiobolomycosis 10.8 CXCL8 IL10 TNF
31 spirillary rat-bite fever 10.8 CXCL8 IL6 TNF
32 drug rash with eosinophilia and systemic symptoms 10.8 CXCL8 IL10 IL6
33 halal setton wang syndrome 10.8 CXCL8 TLR2 TNF
34 steatorrhea 10.8 CXCL8 IFNG TNF
35 distal monosomy 7q36 10.8 CXCL8 IFNG IL10
36 spindle cell hemangioma 10.8 IFNG IL10 TNF
37 congenital insensitivity to pain with hyperhidrosis 10.8 CXCL8 IL10 TLR4
38 sternal cleft 10.8 IFNG IL1B TNF
39 ethmoid sinus adenocarcinoma 10.8 IL10 IL6 TNF
40 mycobacterium kansasii 10.8 CXCL8 TLR2 TNF
41 oculomotor nerve paralysis 10.8 CXCL8 IL1B IL6
42 herpangina 10.8 IFNG IL10 IL6
43 common peroneal nerve lesion 10.8 CXCL8 IL1B IL6
44 tumefactive multiple sclerosis 10.8 CXCL8 TLR2 TNF
45 psychologic dyspareunia 10.8 IFNG IL10 TNF
46 myofascial pain syndrome 10.8 CXCL8 IL10 IL6
47 combined cellular and humoral immune defects with granulomas 10.8 HSPD1 IFNG IL10
48 epulis 10.8 CXCL8 IL1B TNF
49 primary biliary cirrhosis 10.8 IL10 IL6 TNF
50 acute monoblastic leukemia 10.8 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pelvic pain, pruritus

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 NOS2 RAF1 TNF CASP1 CD40LG CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 NOS2 RAF1 TNF CASP1 CD40LG CXCL8
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.46 CASP1 CD40LG CD79A HSPD1 IDO1 IFNG
2 cardiovascular system MP:0005385 10.44 CASP1 CD40LG CRP IDO1 IFNG IL10
3 hematopoietic system MP:0005397 10.43 TNF CASP1 CD40LG CD79A IDO1 IFNG
4 immune system MP:0005387 10.42 CASP1 CD40LG CD79A CRP IDO1 IFNG
5 homeostasis/metabolism MP:0005376 10.41 MAPK14 NOS2 RAC1 RAF1 TLR2 TLR4
6 integument MP:0010771 10.32 MAPK14 MCL1 NOS2 RAC1 RAF1 TLR2
7 endocrine/exocrine gland MP:0005379 10.31 CASP1 CD40LG IFNG IL10 IL6 MAPK14
8 mortality/aging MP:0010768 10.31 CASP1 CD40LG HSPD1 IFNG IL10 IL1B
9 nervous system MP:0003631 10.2 CASP1 CD40LG CD79A HSPD1 IFNG IL10
10 muscle MP:0005369 10.18 TNF HSPD1 IDO1 IFNG IL10 IL6
11 liver/biliary system MP:0005370 10.16 CD79A IFNG IL10 IL6 MAPK14 NOS2
12 digestive/alimentary MP:0005381 10.15 CASP1 IFNG IL10 IL6 NOS2 TLR2
13 neoplasm MP:0002006 10.15 MAPK14 NOS2 RAF1 TLR2 TLR4 TNF
14 reproductive system MP:0005389 9.97 CASP1 RAC1 CD40LG TLR4 HSPD1 TNF
15 renal/urinary system MP:0005367 9.91 CD79A IDO1 IFNG IL6 NOS2 TLR2
16 respiratory system MP:0005388 9.61 IFNG IL10 IL6 MAPK14 NOS2 RAF1
17 skeleton MP:0005390 9.36 CD40LG IFNG IL10 IL1B IL6 MAPK14

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 564-25-0 54671203
3
Lymecycline Approved Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
5
Emtricitabine Approved, Investigational Phase 4,Phase 2 143491-57-0 60877
6
Cefixime Approved Phase 4,Phase 3 79350-37-1 54362 5362065
7
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
10
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
11
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
12
Menthol Approved Phase 4 2216-51-5 16666
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
19 Anti-HIV Agents Phase 4,Phase 2
20 Anti-Retroviral Agents Phase 4,Phase 2
21 Antiviral Agents Phase 4,Phase 3,Phase 2
22 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
24 Reverse Transcriptase Inhibitors Phase 4
25
Tenofovir Phase 4,Phase 2 147127-20-6 464205
26 Antitubercular Agents Phase 4,Phase 3,Phase 2
27 Contraceptive Agents Phase 4,Phase 3,Phase 2
28 Contraceptives, Oral Phase 4
29 Anthelmintics Phase 4,Phase 3
30 Antimitotic Agents Phase 4
31 Contraceptives, Oral, Combined Phase 4
32
Medroxyprogesterone Phase 4 520-85-4 10631
33 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
35 Contraceptive Agents, Male Phase 4
36 Carboxymethylcellulose Sodium Phase 4,Phase 2
37 Cathartics Phase 4,Phase 2
38 Laxatives Phase 4,Phase 2
39
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
40
Rifampin Approved Phase 3,Phase 2 13292-46-1 5458213 5381226
41
Erythromycin Approved, Vet_approved Phase 3,Phase 2 114-07-8 12560
42 silver nitrate Approved Phase 3
43
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
44
Metronidazole Approved Phase 3 443-48-1 4173
45
Clarithromycin Approved Phase 3 81103-11-9 84029
46
Ethanol Approved Phase 3,Phase 1,Phase 2 64-17-5 702
47
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
48
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
49
Sulfadoxine Approved Phase 3 2447-57-6 17134
50
Iron Approved Phase 3 7439-89-6 23925

Interventional clinical trials:

(show top 50) (show all 227)

id Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
3 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
4 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
5 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
6 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
7 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
8 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
9 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
10 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
11 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
12 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
13 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
14 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
15 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
16 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
17 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
18 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
19 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
20 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4 Azithromycin;Placebo
21 Water Uptake for Health in Amhara Pilot Active, not recruiting NCT02373657 Phase 4
22 Use of Abbott RealTime CT/NG to Detect Chlamydia Trachomatis [CT] & Neisseria Gonorrhoeae [NG] in Men Who Have Sex With Men [MSM] Terminated NCT01291264 Phase 4
23 Hormonal Contraception and Risk of Chlamydia and Gonorrhea Terminated NCT00091728 Phase 4 Depo Medroxyprogesterone acetate;Combined oral contraceptives
24 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
25 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
26 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
27 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
28 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
29 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
30 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3 Ophthalmic gel (placebo);Ganciclovir
31 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
32 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
33 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
34 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
35 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
36 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
37 Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
38 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
39 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
40 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
41 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
42 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
43 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
44 HIV Prevention for African American Teens Completed NCT00279799 Phase 3
45 HIV and STD Prevention for High-Risk, Inner-City, African American Youth Completed NCT00353405 Phase 3
46 A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom Completed NCT01223313 Phase 3
47 Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea Completed NCT01136850 Phase 3 chloroquine, sulphadoxine pyrimethamine, LLIN;azithromycin, sulphadoxine pyrimethamine, LLIN
48 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
49 Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth Completed NCT00131235 Phase 3 Sulfadoxine-pyrimethamine treatment twice during pregnancy;Sulfadoxine-pyrimethamine at 4-week intervals;Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
50 Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS) Completed NCT01239693 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

39
Testes, Endothelial, Eye, T Cells, Prostate, Heart, Smooth Muscle

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 1341)
id Title Authors Year
1
Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs. ( 28930567 )
2018
2
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
3
Frequency and genotypes of Chlamydia trachomatis in patients attending the obstetrics and gynecology clinics in Jalisco, Mexico and correlation with sociodemographic, behavioral, and biological factors. ( 28915869 )
2017
4
Spatial clustering of high load ocular Chlamydia trachomatis infection in trachoma: a cross-sectional population-based study. ( 28472466 )
2017
5
Treatment efficacy of azithromycin 1A g single dose versus doxycycline 100A mg twice daily for 7A days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. ( 28061753 )
2017
6
Free-living and captive turtles and tortoises as carriers of new Chlamydia spp. ( 28950002 )
2017
7
Analysis of laboratory testing results for Chlamydia trachomatis infection in an STI clinic in India: Need for extragenital screening. ( 28088589 )
2017
8
Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line. ( 28913776 )
2017
9
Reduced-cost Chlamydia trachomatis-specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes. ( 28487054 )
2017
10
Topical tenofovir protects against vaginal SHIV infection in macaques co-infected with chlamydia trachomatis and trichomonas vaginalis. ( 28060011 )
2017
11
Qualitative interviews with healthcare staff in four European countries to inform adaptation of an intervention to increase chlamydia testing. ( 28951413 )
2017
12
Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis. ( 28946931 )
2017
13
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017
14
Chlamydia pneumoniae Induces Interferon Gamma Responses in Peripheral Blood Mononuclear Cells in Children with Allergic Asthma. ( 28480606 )
2017
15
Perceived Patient Preference and Clinical Testing for Chlamydia and Gonorrhea in Females. ( 28081613 )
2017
16
Genital and Extragenital Gonorrhea and Chlamydia in Children and Adolescents Evaluated for Sexual Abuse. ( 28072668 )
2017
17
Interventions for treating genital Chlamydia trachomatis infection in pregnancy. ( 28937705 )
2017
18
Distribution of Chlamydia Trachomatis Genotypes in Infective Diseases of the Female Lower Genital Tract. ( 28918430 )
2017
19
Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women. ( 28949051 )
2017
20
Chlamydia trachomatis-induced Fitz-Hugh-Curtis syndrome: a case report. ( 28057084 )
2017
21
Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides. ( 28526018 )
2017
22
Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: a case-control study. ( 28947665 )
2017
23
Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining. ( 28074107 )
2017
24
Impact of rectal gonorrhoea and chlamydia on HIV viral load in the rectum: potential significance for onward transmission. ( 28081680 )
2017
25
Follicular Conjunctivitis due to Chlamydia felis-Case Report, Review of the Literature and Improved Molecular Diagnostics. ( 28770201 )
2017
26
Concordance of chlamydia infections of the rectum and urethra in same-sex male partnerships: a cross-sectional analysis. ( 28056825 )
2017
27
Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe. ( 28449734 )
2017
28
Chlamydia trachomatis regulates innate immune barrier integrity and mediates cytokine and antimicrobial responses in human uterine ECC-1 epithelial cells. ( 28921726 )
2017
29
Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. ( 28951853 )
2017
30
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
31
Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation. ( 28576785 )
2017
32
Molecular characterization of lower vaginal swabs for Human papilloma virus in association with Chlamydia trachomatis infection in Cameroonian Women. ( 28919017 )
2017
33
Chlamydia trachomatis Is Responsible for Lipid Vacuolation in the Amniotic Epithelium of Fetal Gastroschisis. ( 28635162 )
2017
34
The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. ( 28041929 )
2017
35
Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati. ( 28898240 )
2017
36
A simple and rapid DNA extraction method for Chlamydia trachomatis detection from urogenital swabs. ( 28918068 )
2017
37
Authors'reply: Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe. ( 28449737 )
2017
38
Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions. ( 28945814 )
2017
39
Detailed molecular epidemiology of Chlamydia trachomatis in the population of Southampton attending the genitourinary medicine clinic in 2012-13 reveals the presence of long established genotypes and transitory sexual networks. ( 28945766 )
2017
40
Global survey of mRNA levels and decay rates of Chlamydia trachomatis trachoma and lymphogranuloma venereum biovars. ( 28795162 )
2017
41
Clinical characteristics of genital chlamydia infection in pelvic inflammatory disease. ( 28086838 )
2017
42
Evidence for a Di-A/-oxo Diamond Core in the Mn(IV)/Fe(IV) Activation Intermediate of Ribonucleotide Reductase from Chlamydia trachomatis. ( 28075562 )
2017
43
Keeping an Eye on Chlamydia and Gonorrhea Conjunctivitis in Infants in the United States, 2010-2015. ( 28809776 )
2017
44
Lycopene Inhibits Propagation of Chlamydia Infection. ( 28948060 )
2017
45
Development and evaluation of rapid novel isothermal amplification assays for important veterinary pathogens: Chlamydia psittaci and Chlamydia pecorum. ( 28929022 )
2017
46
Comparative study in infertile couples with and without Chlamydia trachomatis genital infection. ( 28086915 )
2017
47
Proportion of Tubal Factor Infertility due to Chlamydia: Finite Mixture Modeling of Serum Antibody Titers. ( 28062393 )
2017
48
Accuracy of tests used to detect infection with Chlamydia trachomatis in asymptomatic pregnant women: a systematic review. ( 28914654 )
2017
49
Neonates Born to Chlamydia-Positive Mothers. ( 28929792 )
2017
50
Syndromic management of sexually transmissible infections in resource-poor settings: a systematic review with meta-analysis of the abnormal vaginal discharge flowchart for Neisseria gonorrhoea and Chlamydia trachomatis. ( 28838352 )
2017

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CASP1 CD40LG CD79A CRP CXCL8 IFNG
2
Show member pathways
13.81 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
3
Show member pathways
13.66 CXCL8 IFNG IL10 IL1B IL6 MAPK14
4
Show member pathways
13.58 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
5
Show member pathways
13.54 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
6
Show member pathways
13.42 CASP1 CD40LG CXCL8 IL10 IL1B IL6
7
Show member pathways
13.37 CD79A IFNG IL1B MAPK14 RAC1 RAF1
8
Show member pathways
13.16 CASP1 CXCL8 IL1B IL6 MAPK14 NOS2
9
Show member pathways
13.04 MAPK14 NOS2 RAB14 RAC1 RAF1 TNF
10
Show member pathways
13.04 CD40LG CXCL8 HSPD1 IFNG IL10 IL1B
11
Show member pathways
13.01 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
12
Show member pathways
13 CASP1 CD79A MAPK14 RAC1 RAF1 TNF
13
Show member pathways
12.97 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
14
Show member pathways
12.95 CXCL8 IFNG IL10 IL1B IL6 MAPK14
15
Show member pathways
12.9 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
16 12.85 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
17
Show member pathways
12.84 CD40LG IL1B IL6 TLR2 TLR4 TNF
18 12.82 IL6 MCL1 RAC1 RAF1 TLR2 TLR4
19
Show member pathways
12.81 CD40LG IFNG IL1B MAPK14 RAF1 TNF
20
Show member pathways
12.81 CD40LG CD79A IFNG IL10 RAC1 RAF1
21
Show member pathways
12.8 CASP1 CD40LG IL1B MAPK14 RAC1 RAF1
22
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 NOS2
23
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 MCL1
24 12.77 CXCL8 IL6 NOS2 RAC1 RAF1
25 12.73 CD40LG CD79A IDO1 IFNG IL10 IL1B
26
Show member pathways
12.7 CD79A MAPK14 RAC1 RAF1 TNF
27
Show member pathways
12.62 CD40LG IFNG IL10 IL1B IL6 MAPK14
28
Show member pathways
12.61 IL1B MAPK14 NOS2 RAC1 RAF1
29
Show member pathways
12.54 CXCL8 IFNG IL1B IL6 MAPK14 TLR2
30 12.49 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
31
Show member pathways
12.48 CXCL8 MAPK14 NOS2 RAC1 RAF1
32
Show member pathways
12.44 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
33
Show member pathways
12.42 MAPK14 RAF1 TLR2 TLR4
34
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
35 12.39 IFNG IL6 NOS2 TLR2 TLR4 TNF
36 12.38 CXCL8 HSPD1 IL10 IL1B IL6 TNF
37
Show member pathways
12.37 IFNG IL10 IL6 MCL1 RAF1
38
Show member pathways
12.37 CXCL8 IFNG IL10 IL1B IL6 TNF
39
Show member pathways
12.36 CXCL8 IFNG IL1B IL6 NOS2 TLR2
40
Show member pathways
12.33 CD40LG IFNG IL10 IL1B MAPK14 NOS2
41 12.31 HSPD1 IFNG IL10 IL1B IL6 MAPK14
42
Show member pathways
12.28 MAPK14 RAC1 RAF1 TNF
43 12.26 IFNG IL1B MAPK14 RAC1 TNF
44 12.23 IFNG IL1B MAPK14 RAC1 TNF
45
Show member pathways
12.21 IL10 IL6 MAPK14 RAF1
46
Show member pathways
12.21 IL1B MAPK14 RAF1 TLR2 TLR4
47 12.21 CXCL8 IL10 IL1B IL6 MCL1 NOS2
48 12.18 CXCL8 MAPK14 RAF1 TNF
49 12.18 CD79A IFNG IL10 IL6 TNF
50 12.16 CXCL8 IFNG IL1B IL6 MAPK14 RAF1

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 CASP1 CD40LG CRP CXCL8 IFNG IL10
2 extracellular space GO:0005615 9.81 CD40LG CRP CXCL8 HSPD1 IFNG IL10
3 intracellular GO:0005622 9.56 CD40LG CXCL8 MAPK14 NOS2 RAB14 RAC1
4 lipopolysaccharide receptor complex GO:0046696 9.32 HSPD1 TLR4
5 external side of plasma membrane GO:0009897 9.1 CD40LG CD79A IFNG IL6 TLR4 TNF

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.98 CRP IL6 TLR2 TNF
2 movement of cell or subcellular component GO:0006928 9.97 CXCL8 IFNG MAPK14 RAC1
3 cellular response to mechanical stimulus GO:0071260 9.97 CASP1 IL1B RAC1 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 CD40LG IL1B IL6 TLR2 TLR4 TNF
5 regulation of insulin secretion GO:0050796 9.95 IFNG IL1B NOS2 TNF
6 positive regulation of T cell proliferation GO:0042102 9.94 CD40LG IFNG IL1B IL6
7 positive regulation of JNK cascade GO:0046330 9.93 IL1B TLR4 TNF
8 response to insulin GO:0032868 9.93 IL10 IL6 TLR2
9 response to glucocorticoid GO:0051384 9.93 IL10 IL6 TNF
10 B cell differentiation GO:0030183 9.92 CD40LG CD79A IL10
11 neutrophil chemotaxis GO:0030593 9.92 CXCL8 IFNG IL1B
12 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
13 positive regulation of tumor necrosis factor production GO:0032760 9.9 IFNG TLR2 TLR4
14 positive regulation of interferon-gamma production GO:0032729 9.9 HSPD1 IL1B TLR4 TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.89 IL1B MCL1 TNF
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 HSPD1 TLR2 TLR4
17 positive regulation of cytokine secretion GO:0050715 9.87 CASP1 IL10 TNF
18 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TNF
19 B cell proliferation GO:0042100 9.87 CD40LG CD79A HSPD1 IL10
20 response to bacterium GO:0009617 9.86 CASP1 IL6 NOS2 TLR4
21 defense response to protozoan GO:0042832 9.85 IFNG IL10 IL6
22 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B TLR2 TLR4 TNF
23 positive regulation of interleukin-10 production GO:0032733 9.84 CD40LG HSPD1 TLR2 TLR4
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.83 IFNG IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.83 IFNG IL10 TNF
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.83 IL1B TLR2 TLR4 TNF
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B IL6 TLR4 TNF
28 response to molecule of bacterial origin GO:0002237 9.81 CXCL8 IL10 TLR2
29 response to lipopolysaccharide GO:0032496 9.81 CASP1 IDO1 IL10 IL1B IL6 MAPK14
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 IL10 IL1B TNF
31 positive regulation of interleukin-6 production GO:0032755 9.8 HSPD1 IL1B IL6 TLR2 TLR4 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.79 IFNG IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.78 CRP IL6 TNF
34 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR2 TLR4 TNF
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B MAPK14 TLR2 TLR4 TNF
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.76 IFNG IL10 TLR4
37 regulation of defense response to virus by host GO:0050691 9.75 IFNG IL1B
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.74 IFNG IL1B
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF
40 death-inducing signaling complex assembly GO:0071550 9.74 RAF1 TNF
41 endothelial cell apoptotic process GO:0072577 9.74 IL10 TNF
42 regulation of establishment of endothelial barrier GO:1903140 9.74 IL1B TNF
43 regulation of cytokine production involved in inflammatory response GO:1900015 9.73 MAPK14 NOS2
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.73 IL10 TNF
45 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.73 IFNG TLR4
46 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.73 IL6 TNF
47 positive regulation of interleukin-12 production GO:0032735 9.73 CD40LG HSPD1 IDO1 IFNG TLR2 TLR4
48 positive regulation of fever generation GO:0031622 9.72 IL1B TNF
49 regulation of immunoglobulin secretion GO:0051023 9.72 CD40LG TNF
50 sequestering of triglyceride GO:0030730 9.72 IL1B TNF

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CD40LG CXCL8 IFNG IL10 IL1B IL6
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
3 lipopolysaccharide binding GO:0001530 9.13 HSPD1 TLR2 TLR4

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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