MCID: CHL065
MIFTS: 59

Cholangiocarcinoma malady

Liver diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Cholangiocarcinoma

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Cholangiocarcinoma, Aliases & Descriptions:

Name: Cholangiocarcinoma 30 9 11 43 47 60
Adult Primary Cholangiocellular Carcinoma 9 60
Adult Primary Cholangiocarcinoma 9
Bile Duct Carcinoma 60
 
Bile Duct Cancer 47
Cholangiosarcoma 9
Cca 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

47
cholangiocarcinoma:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:4947
NCIt38 C4436
MeSH33 D018281
Orphanet47 70567
SNOMED-CT55 70179006, 312104005
ICD10 via Orphanet26 C22.1
UMLS via Orphanet61 C0206698, C0740277
MESH via Orphanet34 D001650, D018281

Summaries for Cholangiocarcinoma

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Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

MalaCards based summary: Cholangiocarcinoma, also known as adult primary cholangiocellular carcinoma, is related to biliary papillomatosis and gallbladder cancer, and has symptoms including abnormality of urine homeostasis, biliary tract neoplasm and pruritus. An important gene associated with Cholangiocarcinoma is PTPN3 (protein tyrosine phosphatase, non-receptor type 3), and among its related pathways are IL-9 Signaling Pathways and O-linked glycosylation of mucins. The compounds trastuzumab and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and small intestine, and related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:9 A bile duct adenocarcinoma that has material basis in bile duct epithelial cells.

Related Diseases for Cholangiocarcinoma

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Diseases related to Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1biliary papillomatosis31.2MUC2
2gallbladder cancer31.2CDX2, CEACAM3, MUC2
3bile duct carcinoma31.0MAGEA3, CEACAM3
4renal cell carcinoma30.7KRT7
5primary biliary cirrhosis30.7KRT19, KRT7, MCL1
6bile duct adenoma30.6KRT19, KRT7
7colon adenocarcinoma30.6CDKN1B, KRT20, LGALS3, MUC5AC, MUC2
8spindle cell sarcoma30.6KRT7, MUC1
9liver cirrhosis30.5KRT19, MUC5AC, TIMP3, AFP
10lung squamous cell carcinoma30.5KRT19, TIMP3
11cystadenocarcinoma30.4CEACAM3, MUC5AC, MUC1, MUC2
12cystadenoma30.4KRT7, CEACAM3, VEGFC
13parathyroid adenoma30.3CDKN1B, LGALS3
14hepatocellular carcinoma30.2CDKN1B, CDX2, KRT19, KRT7, OGG1, MAGEA3
15colorectal cancer30.1CDKN1B, CDX2, KRT19, KRT20, LGALS3, CEACAM6
16glioblastoma30.0CDKN1B, MAGEA3, LGALS3, MCL1, TIMP3, VEGFC
17pancreatic cancer29.9CDX2, KRT19, KRT20, KRT7, CEACAM3, MUC5AC
18adenocarcinoma29.5CDKN1B, CDX2, KRT19, KRT20, KRT7, OGG1
19melanoma29.2CDKN1B, CDX2, MAGEA3, LGALS3, CEACAM3, MUC4
20adenoma29.2CDKN1B, CDX2, KRT19, KRT20, KRT7, OGG1
21breast cancer28.6CDKN1B, CDX2, KRT19, KRT7, OGG1, MAGEA3
22intrahepatic cholangiocarcinoma11.3
23hepatitis10.9
24cholangitis10.8
25sclerosing cholangitis10.8
26ampulla of vater carcinoma10.6MUC2
27inverted papilloma10.5KRT20
28nephrogenic adenoma10.5KRT7
29sertoli cell tumor10.5MUC1
30metanephric adenoma10.5KRT7
31hepatitis b10.5
32opisthorchiasis10.5
33papilloma10.5MUC5AC, MUC2
34ovarian brenner tumor10.5KRT20, KRT7
35pancreatitis10.5
36papillary adenocarcinoma10.5MUC1, MUC2
37contractural arachnodactyly, congenital10.5
38acinar cell carcinoma10.5KRT7, AFP
39mammary paget's disease10.5KRT20, KRT7, MUC1
40dry eye syndrome10.5MUC5AC, MUC4
41islet cell tumor10.5CEACAM3, AFP
42signet ring cell adenocarcinoma10.5KRT20, KRT7, MUC2
43epithelioid sarcoma10.5KRT7, MUC1
44secretory meningioma10.5KRT7, MUC1
45sertoli-leydig cell tumor10.5KRT7, MUC1, AFP
46abrikosov's tumor10.5KRT20, KRT7, MUC1
47bladder adenocarcinoma10.5CDX2, KRT20, KRT7
48thymic carcinoma10.5KRT7, CEACAM3, MUC1
49sarcoma, synovial10.5KRT19, KRT7, MUC1
50clonorchiasis10.5

Graphical network of the top 20 diseases related to Cholangiocarcinoma:



Diseases related to cholangiocarcinoma

Symptoms for Cholangiocarcinoma

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Symptoms:

 47 (show all 9)
  • hepatitis/icterus/cholestasis
  • abnormal colour of the urine/cholic/dark urines
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • pruritus/itching
  • asthenia/fatigue/weakness
  • acute abdominal pain/colic
  • anorexia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling

HPO human phenotypes related to Cholangiocarcinoma:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of urine homeostasis hallmark (90%) HP:0003110
2 biliary tract neoplasm hallmark (90%) HP:0100574
3 pruritus typical (50%) HP:0000989
4 weight loss occasional (7.5%) HP:0001824
5 abdominal pain occasional (7.5%) HP:0002027
6 anorexia occasional (7.5%) HP:0002039
7 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Cholangiocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Cholangiocarcinoma

Search NIH Clinical Center for Cholangiocarcinoma

Genetic Tests for Cholangiocarcinoma

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Anatomical Context for Cholangiocarcinoma

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MalaCards organs/tissues related to Cholangiocarcinoma:

31
Liver, Lymph node, Small intestine, Colon, Endothelial, Brain, T cells, Skeletal muscle, Thyroid, Ovary, Neutrophil, Spinal cord, Kidney, Lung, Pancreas, Breast, Prostate, Testis, Testes, Myeloid, Monocytes, Fetal liver

Animal Models for Cholangiocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Cholangiocarcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4CDKN1B, AFP, MUC2, MUC1, OGG1, KRT19
2MP:00107719.4CDKN1B, KRT19, LGALS3, MUC1, MCL1, TIMP3
3MP:00053819.4MUC2, MUC1, MUC5AC, LGALS3, KRT19, CDX2
4MP:00053799.2AFP, TIMP3, MUC2, MUC1, KRT19, CDX2
5MP:00053879.0VEGFC, PTPN3, TIMP3, MCL1, MUC2, MUC5AC
6MP:00053768.9VEGFC, AFP, TIMP3, MUC2, MUC1, MUC5AC
7MP:00053848.9TIMP3, MCL1, MUC2, LGALS3, OGG1, KRT7
8MP:00053858.9VEGFC, TIMP3, MUC2, LGALS3, KRT19, CDX2
9MP:00107688.6VEGFC, AFP, TIMP3, MCL1, MUC2, LGALS3

Publications for Cholangiocarcinoma

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Articles related to Cholangiocarcinoma:

(show top 50)    (show all 1489)
idTitleAuthorsYear
1
Impact of complications on long-term survival after resection of intrahepatic cholangiocarcinoma. (25903409)
2015
2
Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study. (24247752)
2014
3
Diagnosis and management of intrahepatic cholangiocarcinoma: A comprehensive update for the radiologist. (25240565)
2014
4
Integrins I+vI^6, I+6I^4 and I+3I^1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. (24552196)
2014
5
Prediction of the Postoperative Prognosis of Intrahepatic Cholangiocarcinoma (ICC): Importance of Preoperatively-Determined Anatomic Invasion Level and Number of Tumors. (24122559)
2013
6
Adjuvant chemotherapy in resectable cholangiocarcinoma patients. (23829232)
2013
7
Clinical significances of cancer stem cells markers in patients with intrahepatic cholangiocarcinoma who underwent hepatectomy. (23645762)
2013
8
Chemotherapy for cholangiocarcinoma: An update. (23919111)
2013
9
Pure laparoscopic right hepatectomy by anterior approach with hanging maneuver for large intrahepatic cholangiocarcinoma. (24170066)
2013
10
Hepatobiliary resection with concomitant resection of the inferior vena cava for advanced intrahepatic cholangiocarcinoma: report of a case. (22961194)
2013
11
Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma. (23145869)
2013
12
Comparison of computed tomography- and positron emission tomography-based radiotherapy planning in cholangiocarcinoma. (24051924)
2013
13
Factors affecting survival time of cholangiocarcinoma patients: a prospective study in Northeast Thailand. (23679246)
2013
14
Intrahepatic cholangiocarcinoma: impact of genetic hemochromatosis on outcome and overall survival after surgical resection. (23183056)
2013
15
Anticancer effect of arsenic trioxide on cholangiocarcinoma: in vitro experiments and in vivo xenograft mouse model. (23467906)
2013
16
Infiltration of peritumoural but tumour-free parenchyma with IgG4-positive plasma cells in hilar cholangiocarcinoma and pancreatic adenocarcinoma. (23602806)
2013
17
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
18
Clinicopathological significance of E-cadherin, I^-catenin and epidermal growth factor receptor expression in intrahepatic cholangiocarcinoma. (22281980)
2012
19
Treatment of recurrent intrahepatic cholangiocarcinoma. (23132419)
2012
20
Periductal infiltrating type of intrahepatic cholangiocarcinoma: a rare macroscopic type without any apparent mass. (22350300)
2012
21
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
22
Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma. (21607649)
2011
23
MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint. (21809359)
2011
24
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
25
Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma. (21347516)
2011
26
A case of intrahepatic cholangiocarcinoma with marked mucus production. (22128317)
2011
27
Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma. (21438129)
2011
28
Ubiquitin-specific protease 14 expression associated with intrahepatic cholangiocarcinoma cell differentiation. (21627382)
2011
29
Radiofrequency ablation of intrahepatic cholangiocarcinoma: preliminary experience. (20411389)
2010
30
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
31
The E-cadherin repressor slug and progression of human extrahepatic hilar cholangiocarcinoma. (20594328)
2010
32
The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival. (19626372)
2009
33
Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma. (19434454)
2009
34
Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma. (19582476)
2009
35
Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? (18329969)
2008
36
A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. (18081149)
2008
37
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. (18624901)
2008
38
Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma. (17955299)
2008
39
Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence. (18417680)
2008
40
Influence of hepatic resection margin on recurrence and survival in intrahepatic cholangiocarcinoma. (18685896)
2008
41
Indications for surgical treatment of intrahepatic cholangiocarcinoma with lymph node metastases. (18670844)
2008
42
14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma. (17391729)
2007
43
Relation of cholangiocarcinomas to clonorchiasis and bile duct stones. (15185021)
2004
44
Major hepatic resection for hilar cholangiocarcinoma: analysis of 46 patients. (15136352)
2004
45
A case of combined hepatocellular-cholangiocarcinoma with sarcomatous transformation and second primary colon cancer]. (15218348)
2004
46
Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. (12514785)
2002
47
Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. (12213730)
2002
48
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. (12143044)
2002
49
Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma. (8554130)
1996
50
Chronic postcolectomy pericholangitis and cholangiocarcinoma. (2995479)
1985

Variations for Cholangiocarcinoma

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Cosmic variations for Cholangiocarcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110690TP53biliary tract,bile duct,carcinoma,adenocarcinoma1

Expression for genes affiliated with Cholangiocarcinoma

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Search GEO for disease gene expression data for Cholangiocarcinoma.

Pathways for genes affiliated with Cholangiocarcinoma

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Pathways related to Cholangiocarcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
10.0CDKN1B, MUC1, MCL1
2
Show member pathways
9.8MUC5AC, MUC4, MUC1, MUC2
3
Show member pathways
9.6MUC2, MUC1, MUC4, MUC5AC, CDX2

Compounds for genes affiliated with Cholangiocarcinoma

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Compounds related to Cholangiocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1trastuzumab43 49 1212.0MUC4, CDKN1B, VEGFC, MUC1
2[alcl]4310.0MUC1, CDKN1B, MCL1
3mucicarmine439.9MUC1, CEACAM3, KRT7, KRT20
4galactose439.9CEACAM3, AFP, MUC2, MUC1, LGALS3
5gemcitabine43 49 1211.9MCL1, CEACAM6, MUC1, CDKN1B
612-o-tetradecanoylphorbol 13-acetate439.9MUC2, CDKN1B, MUC1, MCL1, TIMP3
7dmso439.8MUC5AC, MUC2, AFP, OGG1, CDKN1B, MUC1
8adriamycin439.8MUC1, CEACAM3, OGG1, KRT19, AFP
9actinomycin d439.7CDKN1B, MUC1, MUC2, MCL1, AFP
10carbohydrates439.7KRT19, MUC2, MUC1, MUC5AC, LGALS3, KRT7
11polysaccharide439.6MUC1, AFP, LGALS3, KRT7, MUC5AC
12paclitaxel43 49 1211.6PTPN3, KRT19, MCL1, AFP, CDKN1B
13pd 98,059439.6TIMP3, MUC5AC, CDKN1B, VEGFC, PTPN3, MUC2
14heparin43 28 24 1212.6AFP, VEGFC, TIMP3, PTPN3, LGALS3, CDKN1B
15cisplatin43 49 59 1212.6CDKN1B, AFP, MCL1, MUC1, LGALS3, KRT19
16estradiol43 24 1211.6KRT19, MUC1, AFP, TIMP3, CDKN1B, VEGFC
17formaldehyde43 2410.6KRT20, KRT7, LGALS3, MUC1, CDKN1B, KRT19
185fluorouracil439.6MCL1, AFP, MUC2, MUC1, CDKN1B, MUC5AC
19ribonucleic acid439.5VEGFC, TIMP3, MUC1, MUC5AC, KRT20, KRT19
20glutamate439.5MCL1, AFP, PTPN3, TIMP3, LGALS3, OGG1
21b 723439.5KRT20, KRT19, AFP, MUC1, CEACAM3, KRT7
22glycogen43 2410.5LGALS3, KRT7, AFP, MCL1, KRT19, CDKN1B
23ly294002439.5MCL1, TIMP3, MUC2, VEGFC, CDKN1B
24matrigel439.5KRT7, KRT19, LGALS3, MUC4, MUC1, TIMP3
25methotrexate49 43 1211.5MUC1, MUC5AC, AFP, MUC2, CDKN1B, KRT7
26threonine439.5PTPN3, AFP, CDKN1B, LGALS3, MUC5AC, MUC2
27cysteine439.5TIMP3, MUC2, PTPN3, MUC1, MUC5AC, LGALS3
28sialic acid439.4MUC2, KRT7, LGALS3, CEACAM3, MUC5AC, MUC1
29butyrate439.4MCL1, AFP, PTPN3, MUC2, MUC1, LGALS3
30cholesterol43 28 24 1212.3MUC4, MUC5AC, CDKN1B, MUC1, MUC2, PTPN3
31lipid439.3AFP, VEGFC, TIMP3, MCL1, MUC1, PTPN3
32wortmannin439.3PTPN3, TIMP3, MCL1, LGALS3, CDKN1B
33steroid439.3TIMP3, CEACAM3, CDX2, KRT19, MUC4, AFP
34thymidine43 2410.3CDKN1B, MUC1, CEACAM3, OGG1, KRT19, CDX2
35nitric oxide43 24 1211.3CDKN1B, MUC1, VEGFC, MUC5AC, CEACAM3, LGALS3
36dexamethasone43 49 28 1212.2MUC1, VEGFC, AFP, PTPN3, MUC5AC, MUC4
37hematoxylin439.2MUC2, MUC1, MUC5AC, CEACAM3, LGALS3, KRT7
38phosphatidylinositol439.1MUC4, CDKN1B, LGALS3, CEACAM6, MUC5AC, VEGFC
39serine439.1MUC2, MCL1, MUC5AC, LGALS3, OGG1, KRT19
40testosterone43 59 24 1212.0KRT19, KRT20, CDKN1B, VEGFC, AFP, TIMP3
41oligonucleotide438.8CDX2, OGG1, LGALS3, MAGEA3, VEGFC, AFP
42glucose438.7TIMP3, PTPN3, AFP, VEGFC, KRT19, CDKN1B
43retinoic acid43 249.6MUC2, CDKN1B, KRT19, AFP, TIMP3, MCL1
44vegf438.6KRT20, CEACAM3, MUC1, AFP, VEGFC, MCL1
45oxygen43 249.6VEGFC, KRT19, OGG1, LGALS3, CEACAM3, MUC5AC
46calcium43 49 24 1211.2KRT19, MCL1, CDX2, CEACAM6, CEACAM3, MUC5AC
47progesterone43 28 59 24 1212.1MUC4, CDKN1B, CDX2, KRT19, KRT20, VEGFC
48estrogen438.0LGALS3, CEACAM3, MUC5AC, MUC4, MUC1, MUC2
49tyrosine438.0MUC4, MUC1, MCL1, PTPN3, AFP, MUC5AC
50paraffin437.6KRT7, KRT20, KRT19, CDX2, CDKN1B, VEGFC

GO Terms for genes affiliated with Cholangiocarcinoma

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Cellular components related to Cholangiocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.7KRT19, KRT20, KRT7
2Golgi lumenGO:00057969.5MUC5AC, MUC4, MUC1, MUC2

Biological processes related to Cholangiocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of membrane protein ectodomain proteolysisGO:005104510.2TIMP3, PTPN3
2positive chemotaxisGO:005091810.1LGALS3, VEGFC
3maintenance of gastrointestinal epitheliumGO:003027710.0MUC4, MUC2
4O-glycan processingGO:00162669.9MUC5AC, MUC4, MUC1, MUC2
5negative regulation of mitotic cell cycleGO:00459309.8CDKN1B, PTPN3
6post-translational protein modificationGO:00436879.8MUC2, MUC1, MUC4, MUC5AC

Molecular functions related to Cholangiocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:004205610.1LGALS3, VEGFC
2protein bindingGO:00055157.4CDKN1B, VEGFC, PTPN3, TIMP3, MCL1, MUC2

Products for genes affiliated with Cholangiocarcinoma

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Sources for Cholangiocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet