Cholangiocarcinoma malady

Wikipedia: Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial...⁴⁴ more...

MalaCards: Cholangiocarcinoma, also known as adult primary cholangiocellular carcinoma, is related to intrahepatic cholangiocarcinoma and carcinoma. An important gene associated with Cholangiocarcinoma is KRT7 (keratin 7), and among its related pathways are ILK Signaling and Molecular Mechanisms of Cancer. The compounds serine and lipid have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and small intestine, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Descriptions:

cholangiocarcinoma 6 8 32 43 adult primary cholangiocellular carcinoma 6 43 cholangiocarcinoma (morphologic abnormality) 6

adult primary cholangiocarcinoma 6 cholangiosarcoma 6

Diseases related to cholangiocarcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 854)

id	Related Disease	Score	Top Affiliating Genes
1	intrahepatic cholangiocarcinoma	120.7	ZNF569, ZNF205, ZNF219, ZNF792, ZNF189, PICK1
2	carcinoma	76.7	ZNF189, PIK3CA, PIK3CG, NCAM1, PDCD4, RECK
3	prostatitis	61.0	PIK3CA, PIK3CG, LRRC26, KLHL20, NCAM1, PDCD4
4	hepatocellular carcinoma	60.7	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
5	adenocarcinoma	59.0	PIK3CA, PIK3CG, NCAM1, RECK, KIT, SFN
6	pancreatitis	57.8	PIK3CA, PIK3CG, LRRC26, NCAM1, RECK, KIT
7	leukemia	53.8	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
8	colon cancer	50.2	PIK3CA, PIK3CG, LRRC26, NCAM1, PDCD4, RECK
9	melanoma	47.6	PIK3CA, PIK3CG, NCAM1, RECK, KIT, SFN
10	hypoxia	43.3	PIK3CA, PIK3CG, KLHL20, PDCD4, RECK, KIT
11	hepatitis b	38.9	PIK3CA, PIK3CG, PCNA, RB1, SELE, SERPINA1
12	liver cancer	35.6	PIK3CG, RB1, SERPINB5, SERPINA1, NAT1, NAT2
13	cholangitis	34.8	PCNA, BIRC5, BCL2L11, SCT, MUC2, MUTYH
14	hepatitis	34.6	SERPINA1, FASLG, FAS, GPT, GPC3, F2
15	gallbladder carcinoma	34.5	PIK3CA, NCAM1, PCNA, SERPINB5, NAT2, VEGFA
16	sclerosing cholangitis	33.9	SCT, MUTYH, CEACAM3, CDKN2A, MICA, IL6
17	primary sclerosing cholangitis	33.7	SCT, MUTYH, CEACAM3, CDKN2A, MICA, IL6
18	liver cirrhosis	32.8	NCAM1, SERPINA1, SERPINA3, RAF1, RASSF1, SCT
19	herpes simplex	32.3	PIK3CA, PIK3CG, RECK, PCNA, VIM, VEGFA
20	pancreatic cancer	31.9	SERPINB5, VEGFA, RAF1, BIRC5, KDR, SCT
21	biliary tract cancer	31.8	KIT, SERPINA1, VIM, BRAF, VEGFA, BMP6
22	gastric cancer	31.8	ZNF189, PIK3CA, PIK3CG, LRRC23, PDCD4, RECK
23	bile duct carcinoma	31.6	PIK3CG, KIT, VEGFC, MYC, BCL2, MUC1
24	viral hepatitis	31.3	PCNA, SERPINA1, SERPINA3, UROD, MUC6, BAX
25	hepatitis c	31.3	SERPINA1, MTTP, IL6R, FAS, GPT, F2
26	jaundice	31.0	SELL, CLDN4, SCT, CEACAM3, FUT4, CD14
27	primary biliary cirrhosis	30.8	SELL, VDR, RARA, SCT, MCL1, GPT
28	bile duct cancer	30.8	NCAM1, VEGFA, BCL2, BAX, CEACAM3, FSCN1
29	neuronitis	30.6	PIK3CA, PICK1, PIK3CG, NCAM1, RECK, KIT
30	ptosis	30.2	BMF, BIRC5, PAWR, PARP1, BCL2, BCL2L11
31	t-cell leukemia	29.4	PIK3CG, MYC, RAF1, BIRC5, BCL2, BCL2L1
32	colorectal cancer	29.3	NAT1, NAT2, VDR, MTHFR, MSH2, MLH1
33	hemochromatosis	29.3	BTN3A1, SERPINA1, BMP6, UROD, LCN2, GSTP1
34	hypercalcemia	29.3	VIM, VDR, BMP6, SCT, MGP, IL6
35	thyroiditis	28.1	PIK3CA, PIK3CG, NCAM1, RECK, KIT, SFN
36	ovarian cancer	27.5	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
37	esophagitis	26.2	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
38	breast carcinoma	26.1	PIK3CA, PIK3CG, RECK, KIT, SFN, PCNA
39	lung carcinoma	24.7	PIK3CA, PIK3CG, NCAM1, RECK, PCNA, RB1
40	adenoma	24.3	PIK3CA, NCAM1, PDCD4, RECK, KIT, PCNA
41	cervicitis	24.1	PIK3CA, PIK3CG, PDCD4, RECK, KIT, SFN
42	malaria	23.8	PDCD4, RECK, CNOT1, KIAA1609, SFN, PCNA
43	alzheimer's disease	23.4	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIF20B
44	gonococcal synovitis	23.4	PIK3CA, PIK3CG, NCAM1, RECK, SELE, SELL
45	neuroblastoma	23.3	PIK3CA, PIK3CG, NCAM1, RECK, KIT, PCNA
46	ovarian carcinoma	23.1	PIK3CA, PIK3CG, PDCD4, RECK, KIT, PCNA
47	sarcoma	22.7	PIK3CA, PIK3CG, NCAM1, RECK, KIT, PCNA
48	fibrosis	22.6	PIK3CA, PIK3CG, RECK, KIT, PCNA, SELE
49	colon carcinoma	22.6	PIK3CA, PIK3CG, NCAM1, PDCD4, KIT, SELE
50	cholesterol	22.2	PIK3CA, PIK3CG, RECK, RB1, SELE, SELL

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cholangiocarcinoma:

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MGI Mouse Phenotypes related to cholangiocarcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	24.7	PIK3CA, PIK3CG, KIT, GCLM, RB1, RBL1
2	mortality/aging	MP:0010768	24.3	PIK3CA, NCAM1, PDCD4, RECK, SFN, GCLM
3	cellular phenotype	MP:0005384	23.7	PIK3CA, PICK1, PIK3CG, NCAM1, KIT, SFN
4	growth/size phenotype	MP:0005378	21.0	PIK3CA, PIK3CG, RECK, KIT, SFN, RB1
5	immune system phenotype	MP:0005387	20.2	PDCD4, KIT, SFN, RBL1, SELL, VIM
6	hematopoietic system phenotype	MP:0005397	18.3	KIT, SFN, PCNA, RBL1, BRAF, MYO1E
7	cardiovascular system phenotype	MP:0005385	18.2	PIK3CA, PIK3CG, RECK, KIT, RB1, RBL1
8	nervous system phenotype	MP:0003631	18.0	PICK1, RECK, KIT, RB1, RBL1, SERPINH1
9	reproductive system phenotype	MP:0005389	17.5	PIK3CA, PICK1, PDCD4, SFN, RBL1, NAT1
10	tumorigenesis	MP:0002006	17.2	PIK3CA, PDCD4, KIT, SFN, RB1, RBL1
11	behavior/neurological phenotype	MP:0005386	17.0	PIK3CA, NCAM1, KIT, RB1, RBL1, SELE
12	integument phenotype	MP:0010771	16.3	PIK3CG, RECK, KIT, SFN, RB1, RBL1
13	digestive/alimentary phenotype	MP:0005381	16.3	KIT, SFN, RB1, RBL1, BRAF, VEGFA
14	embryogenesis phenotype	MP:0005380	16.0	PIK3CA, RECK, KIT, SFN, RBL1, SERPINB5
15	skeleton phenotype	MP:0005390	14.9	PIK3CG, RECK, KIT, SFN, RB1, RBL1
16	normal phenotype	MP:0002873	14.7	RBL1, SELE, NAT1, BRAF, VEGFA, MYC
17	muscle phenotype	MP:0005369	14.7	PIK3CA, PIK3CG, KIT, RB1, RBL1, VIM
18	renal/urinary system phenotype	MP:0005367	14.6	PDCD4, KIT, BRAF, MYO1E, RARA, RARB
19	endocrine/exocrine gland phenotype	MP:0005379	14.4	PICK1, PDCD4, SFN, RBL1, SELL, PARL
20	vision/eye phenotype	MP:0005391	14.3	PIK3CA, NCAM1, KIT, SFN, RB1, RBL1
21	limbs/digits/tail phenotype	MP:0005371	13.9	RECK, KIT, SFN, RB1, RBL1, VEGFA
22	liver/biliary system phenotype	MP:0005370	13.9	RECK, KIT, SFN, RBL1, VEGFA, BID
23	no phenotypic analysis	MP:0003012	13.3	PCNA, RB1, RBL1, VEGFA, MYC, MYO1E
24	craniofacial phenotype	MP:0005382	12.4	KIT, RBL1, BMI1, LAMB3, XPA, L1CAM
25	pigmentation phenotype	MP:0001186	12.2	KIT, RB1, BRAF, MYC, RAD9A, BCL2
26	respiratory system phenotype	MP:0005388	12.1	SELL, BID, PARL, FUZ, CDK5, CD14
27	other phenotype	MP:0005395	12.0	RECK, SERPINH1, RARA, RARB, KDR, LAMC2
28	adipose tissue phenotype	MP:0005375	11.9	PIK3CA, RB1, RBL1, BRAF, MYC, BCL2
29	hearing/vestibular/ear phenotype	MP:0005377	11.8	KIT, SFN, RB1, VDR, MYC, RARA

Articles related to cholangiocarcinoma:

(show top 50)    (show all 399)

id	Title	Authors	Year	Affiliating Genes
1	Expression and clinical significance of hepatoma-deri ved growth factor as a prognostic factor in human hilar cholangiocarcinoma. (20848225)	Liu Y.F.... Xu K.S.	2011	HDGF
2	MicroRNA down-regulated in human cholangiocarcinoma c ontrol cell cycle through multiple targets involved in the G1/S checkpoint. (21809359)	Olaru A.V.... Selaru F.M.	2011	MIR494
3	A novel serum carbohydrate marker on mucin 5AC: value s for diagnostic and prognostic indicators for cholangiocarcinoma. (21287531)	Silsirivanit A.... Sakaguchi N.	2011	MUC5AC
4	Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. (21618579)	Fabris L.... Strazzabosco M.	2011	S100A4
5	Clinicopathologic significance of slug expression in human intrahepatic cholangiocarcinoma. (20503457)	Zhang K.J.... Zhang D.L.	2010	SNAI2
6	Alpha-fetoprotein producing cells act as cancer proge nitor cells in human cholangiocarcinoma. (20149523)	Ishii T.... Uemoto S.	2010	AFP
7	Circulating CD14(+) CD16(+) monocyte levels predict t issue invasive character of cholangiocarcinoma. (20636398)	Subimerb C.... Wongkham S.	2010	CD14, FCGR3A
8	Targeting the IL-6 dependent phenotype can identify n ovel therapies for cholangiocarcinoma. (21179572)	Braconi C.... Patel T.	2010	IL6
9	Transcriptional induction of minichromosome maintenan ce protein 7 (Mcm7) in human cholangiocarcinoma cells treated with Clonorchis s inensis excretory-secretory products. (20236609)	Kim D.W.... Seo S.B.	2010	MCM7
10	Gene expression profiling of cholangiocarcinoma-deriv ed fibroblast reveals alterations related to tumor progression and indicates pe riostin as a poor prognostic marker. (20096135)	Utispan K.... Thuwajit C.	2010	POSTN
11	PBK/TOPK in the differential diagnosis of cholangioca rcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma. (19954816)	He F.... Huang G.	2010	PBK
12	Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis. (19066964)	Kim Y.J.... Bae Y.M.	2009	PTGS2
13	Serum and bile biomarkers for cholangiocarcinoma. (19396965)	Alvaro D.	2009	MUC4
14	Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. (19082442)	Yeh C.N.... Chen M.F.	2009	MUC4
15	Rapamycin inhibits growth of cholangiocarcinoma cells. (19453019)	Okada T.... Kubota K.	2009	PTEN, PSMC4
16	CD10+ fibroblasts are more involved in the progressio n of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic chol angiocarcinoma. (19817893)	Nishihara Y.... Tsuneyoshi M.	2009	MME
17	The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. (19330734)	KirimlioA9lu H.... KirimlioA9lu V.	2009	MMP2, MMP9, MMP14
18	Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence. (18417680)	Vij K.... Wang H.L.	2008	AFP
19	Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? (18329969)	Chiu C.T.... Chen M.F.	2008	MUC2, CDX2, MUC5AC
20	Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas. (17550320)	Kim B.H.... Kang G.H.	2007	ARID4A
21	Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. (17527078)	Haas S.... Fischer H.P.	2007	NCAM1
22	Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma. (17640714)	Batmunkh E.... Kovalszky I.	2007	AGRN
23	An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas. (17239935)	DeHaan R.D.... Halling K.C.	2007	CDKN2A
24	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. (17165088)	Schmitz K.J.... Baba H.A.	2007	PTGS2
25	Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling. (17551669)	Zhang L.... Leng J.	2007	MAPK1
26	CA 19-9 and survival in advanced and unresectable pancreatic adenocarcinoma and cholangiocarcinoma. (19089662)	Ali C.W.... Highley M.S.	2007	CEACAM3
27	Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (16712791)	Wang A.G.... Kim N.S.	2006	EGFR, RARA, SPP1
28	Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma. (16792547)	Ohira S.... Nakanuma Y.	2006	TGFB1
29	Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. (16565491)	Ohira S.... Nakanuma Y.	2006	CXCR4, CXCL12
30	Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas. (16142313)	Tokumoto N.... Asahara T.	2005	CCND1
31	Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. (15884115)	Tepsiri N.... Tassaneeyakul W.	2005	GSTP1, ABCC1, ABCB1
32	Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. (15690474)	Sirica A.E.	2005	ERBB2, PTGS2, MUC1
33	Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance (16083599)	Zhang B.Y.... Wu L.Q.	2005	TGFBR2, TGFB1, SMAD4
34	The ratio of MMP-2 to TIMP-2 in hilar cholangiocarcinoma: a semi-quantitative study. (15567754)	Xiao M.... Chang W.L.	2004	MMP2, TIMP2
35	Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. (15213623)	Jan Y.Y.... Chen M.F.	2004	MUC1, MUC2, MUC5AC
36	Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma. (14656942)	Yeh C.N.... Chen M.F.	2004	ERBB2
37	Rhabdoid cholangiocarcinoma: a variant of cholangiocarcinoma with aggressive behavior. (15227745)	Lim B.J.... Park Y.N.	2004	VIM
38	Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement. (12654561)	Nagi P.... Yamamoto M.	2003	PTGS2, GRP
39	Alteration of the fragile histidine triad gene in intrahepatic cholangiocarcinoma. (12867802)	Koch E.... Ballhausen W.G.	2003	CTNNB1, FHIT
40	Bile from a patient with anomalous pancreaticobiliary ductal union promotes the proliferation of human cholangiocarcinoma cells via COX-2 pathway. (12717864)	Wu G.S.... Wang D.Y.	2003	PTGS2
41	Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. (12213730)	Lee S.... Kang G.H.	2002	CDH1, PTGS2, THBS1
42	COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. (11870367)	Nzeako U.C.... Gores G.J.	2002	PTGS2, TNFRSF10B, TNFRSF10A
43	Synchronous hepatocellular carcinoma and cholangiocarcinoma arising in two different dysplastic nodules. (12379757)	Kwon Y.... Yu E.	2002	KRT7
44	Correlation between expression of MUC1 core protein and outcome after surgery in mass-forming intrahepatic cholangiocarcinoma. (11920540)	Matsumura N.... Nakano M.	2002	MUC1
45	Comparing combined hepatocellular-cholangiocarcinoma and cholangiocarcinoma: a clinicopathological study. (12397714)	Lee C.C.... Chen G.H.	2002	SLPI
46	Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells. (12235080)	Okaro A.C.... Cotter F.E.	2002	BCL2L1, MCL1, TSPO
47	Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma. (11580146)	Momoi H.... Fukumoto M.	2001	MDM2
48	Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells. (10869285)	Yokomuro S.... Demetris A.J.	2000	HGF, IL6, IL6R
49	A human combined hepatocellular and cholangiocarcinoma cell line (KMCH-2) that shows the features of hepatocellular carcinoma or cholangiocarcinoma under different growth conditions. (8738727)	Yano H.... Kojiro M.	1996	ALB
50	The expression and significance of proliferating cell nuclear antigen/cyclin in cholangiocarcinoma and gallbladder carcinoma (8565737)	Yang Z.... Li Y.	1995	PCNA

Genes related to cholangiocarcinoma according to GeneCards:

(show top 50)    (show all 696)

id	Symbol	Description	Score	GeneCards Section Context
1	KRT7	keratin 7	11.0	Publications
2	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
3	MAGEA3	melanoma antigen family A, 3	11.0	Publications
4	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
5	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
6	KRT19	keratin 19	11.0	Publications
7	KRT20	keratin 20	11.0	Publications
8	MUC17	mucin 17, cell surface associated	11.0	Publications
9	MUC4	mucin 4, cell surface associated	11.0	Publications, UniProt Related
10	AFP	alpha-fetoprotein	11.0	Publications
11	ASPH	aspartate beta-hydroxylase	11.0	Publications
12	CDX2	caudal type homeobox 2	11.0	Publications
13	KRT18	keratin 18	11.0	Publications
14	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	11.0	Publications
15	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
16	CFLAR	CASP8 and FADD-like apoptosis regulator	11.0	Publications
17	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
18	MUC1	mucin 1, cell surface associated	11.0	Publications
19	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
20	THBS1	thrombospondin 1	11.0	Publications
21	VEGFC	vascular endothelial growth factor C	11.0	Publications
22	CCNB1	cyclin B1	11.0	Publications
23	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
24	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
25	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
26	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
27	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
28	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
29	GGT1	gamma-glutamyltransferase 1	11.0	Publications
30	NCAM1	neural cell adhesion molecule 1	11.0	Publications
31	PTK2	PTK2 protein tyrosine kinase 2	11.0	Publications
32	FHIT	fragile histidine triad	11.0	Publications
33	LINC00543	long intergenic non-protein coding RNA 543	10.9	Publications
34	APOC1P1	apolipoprotein C-I pseudogene 1	10.9	Publications
35	C17orf61	chromosome 17 open reading frame 61	10.9	Publications
36	LOC100506229	uncharacterized LOC100506229	10.9	Publications
37	TIGD2	tigger transposable element derived 2	10.9	Publications
38	C17orf65	chromosome 17 open reading frame 65	10.9	Publications
39	C17orf76-AS1	C17orf76 antisense RNA 1	10.9	Publications
40	C7orf55	chromosome 7 open reading frame 55	10.9	Publications
41	COX16	COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)	10.9	Publications
42	DMRTC1	DMRT-like family C1	10.9	Publications
43	HOXD-AS1	HOXD cluster antisense RNA 1	10.9	Publications
44	KRTCAP3	keratinocyte associated protein 3	10.9	Publications
45	LIMD2	LIM domain containing 2	10.9	Publications
46	LOC100505633	uncharacterized LOC100505633	10.9	Publications
47	NRARP	NOTCH-regulated ankyrin repeat protein	10.9	Publications
48	NUDT8	nudix (nucleoside diphosphate linked moiety X)-type motif 8	10.9	Publications
49	OVCA2	ovarian tumor suppressor candidate 2	10.9	Publications
50	PIH1D2	PIH1 domain containing 2	10.9	Publications

Pathways related to cholangiocarcinoma according to GeneDecks:

(show top 50)    (show all 269)

id	Pathway	Score	Top Affiliating Genes
1	ILK Signaling36	13.0	KIT, VIM, VEGFC, MYH1, MYO1E, MYO9A
2	Molecular Mechanisms of Cancer36	12.9	PIK3CG, RB1, RBL1, VEGFC, MYC, BMP6
3	Rho Family GTPases36	12.7	KIT, VIM, VEGFC, BMP6, RAF1, KDR
4	Pathways in cancer20	12.4	PIK3CA, PIK3CG, RB1, VEGFA, VEGFC, MYC
5	Apoptosis and Autophagy3	12.1	PDCD4, SERPINB5, MYC, BMF, BID, BIRC5
6	Pancreatic Adenocarcinoma36	12.1	KIT, RB1, BRAF, VEGFC, BMP6, RAF1
7	Focal adhesion20	12.0	PIK3CA, PIK3CG, BRAF, VEGFC, RAF1, KDR
8	Akt Signaling36	12.0	PIK3CG, KIT, VEGFC, RAF1, FLT4, FLT3
9	Cellular Apoptosis Pathway36	11.8	KIT, VEGFC, BMP6, BID, PAWR, KDR
10	Bladder cancer20	11.7	RB1, BRAF, VEGFA, VEGFC, MYC, RAF1
11	Breast Cancer Regulation by Stathmin136	11.7	RAF1, MAP2K2, MAP2K1, CCNB1, IGF1R, CALM1
12	PTEN Pathway36	11.7	KIT, BRAF, VEGFC, KDR, LAMB3, LAMC2
13	MAPK Signaling36	11.7	KIT, BRAF, VEGFC, MYC, BMP6, RAF1
14	eIF2 Pathway36	11.7	KIT, BRAF, VEGFC, BMP6, RAF1, FLT4
15	JAK-STAT Pathway36	11.7	KIT, VEGFC, MYC, BMP6, RAF1, KDR
16	TGF-Beta Pathway36	11.6	VEGFC, BMP6, KDR, BCL2, BAX, CDH1
17	Colorectal Cancer Metastasis36	11.6	BRAF, MYC, BIRC5, BCL2L1, BAX, MSH2
18	Mitochondrial Apoptosis36	11.6	KIT, VEGFC, BMP6, BID, KDR, BCL2
19	Renin-Angiotensin Pathway36	11.6	KIT, VEGFC, BMP6, RAF1, KDR, FLT4
20	Small cell lung cancer20	11.6	PIK3CA, PIK3CG, RB1, MYC, RARB, BCL2
21	Antioxidant Action of Vitamin-C36	11.5	KIT, VEGFC, MYH1, MYO1E, MYO9A, BMP6
22	ERK Signaling36	11.5	KIT, BRAF, VEGFC, MYC, BMP6, RAF1
23	Endometrial cancer20	11.5	PIK3CA, PIK3CG, BRAF, MYC, RAF1, CDH1
24	GSK3 Signaling36	11.5	KIT, VEGFC, BMP6, KDR, CDH2, CDH3
25	p38 Signaling36	11.5	KIT, VEGFC, BMP6, KDR, BCL2, BAX
26	Prostate cancer20	11.5	PIK3CA, PIK3CG, RB1, BRAF, RAF1, BCL2
27	Rac1 Pathway36	11.4	BMP6, RAF1, KDR, BAIAP2, ITGA4, FLT4
28	DHA Signaling36	11.4	KIT, VEGFC, BMP6, BID, KDR, BCL2
29	Estrogen Pathway36	11.4	KIT, BRAF, VEGFC, BMP6, RAF1, KDR
30	Apoptotic Pathways in Synovial Fibroblasts36	11.4	KIT, VEGFC, BMP6, KDR, CFLAR, FLT4
31	Melanoma20	11.4	PIK3CA, PIK3CG, RB1, BRAF, RAF1, CDKN2A
32	p53 Mediated Apoptosis36	11.4	KIT, VEGFC, BMP6, BID, KDR, BCL2
33	Nanog in Mammalian ESC Pluripotency36	11.4	KIT, BRAF, VEGFC, BMP6, RAF1, KDR
34	GPCR Pathway36	11.3	KIT, BRAF, VEGFC, BMP6, RAF1, KDR
35	Chronic myeloid leukemia20	11.3	PIK3CA, PIK3CG, RB1, BRAF, MYC, RAF1
36	Non-small cell lung cancer20	11.3	PIK3CA, PIK3CG, RB1, BRAF, RAF1, RASSF1
37	PPAR Pathway36	11.2	KIT, VEGFC, RAF1, ITGA4, FLT4, MET
38	p70S6K Signaling36	11.1	KIT, VEGFC, BMP6, RAF1, KDR, FLT4
39	Colorectal cancer20	11.1	PIK3CG, BRAF, MSH2, MAP2K1, CASP9, TGFB1
40	14-3-3 Induced Intracellular Signaling36	10.9	VEGFC, RAF1, FLT4, FLT3, MAP2K2, MAPK3
41	Sorafenib Pharmacodynamics34	10.9	PIK3CA, BRAF, RAF1, KDR, FLT4, FLT3
42	Glioblastoma Multiforme36	10.8	RB1, BRAF, RAF1, CDKN1B, MDM2, APC
43	Signal transduction_PTEN pathway41	10.8	PCNA, IGF1R, CASP9
44	Glioma20	10.7	PIK3CA, PIK3CG, RB1, BRAF, RAF1, MTOR
45	Endothelin-1 Signaling Pathway36	10.6	KIT, BRAF, MYC, BMP6, RAF1, FLT4
46	EGF Pathway36	10.6	BRAF, MYC, RAF1, MUC1, CDH1, MAP2K2
47	Pathway_PA16595942534	10.6	KIT, BRAF, RAF1, KDR, FLT4, FLT3
48	JNK Pathway36	10.5	KIT, BMP6, RAF1, KDR, BCL2, BAX
49	Acute myeloid leukemia20	10.3	PIK3CA, PIK3CG, KIT, BRAF, MYC, RARA
50	Signal transduction PTEN pathway10	10.2	PIK3CA, PCNA, RAF1, MTOR, MAP2K2, MAPK3

Compounds related to cholangiocarcinoma according to GeneDecks:

(show top 50)    (show all 479)

id	Compound	Score	Top Affiliating Genes
1	serine32	21.8	PIK3CA, PICK1, PIK3CG, NCAM1, RECK, KIT
2	lipid32	19.1	PIK3CA, PICK1, PIK3CG, NCAM1, RECK, RB1
3	estrogen32	18.8	PCNA, SERPINB5, SET, SERPINA1, SERPINA3, BSG
4	vegf32	17.8	PIK3CA, PIK3CG, NCAM1, RECK, KIT, PCNA
5	retinoic acid32 42 18	19.3	PIK3CA, PIK3CG, NCAM1, KIT, RB1, SELL
6	oxygen32 18	17.5	RB1, SERPINA1, SERPINA3, BID, BIRC5, PARP1
7	arginine32	15.3	PIK3CA, RECK, RBL1, SERPINA3, BRAF, VDR
8	glutamate32	14.8	PIK3CA, NCAM1, PCNA, VIM, BSG, BRAF
9	lactate32	14.7	PIK3CA, NCAM1, RECK, KIT, PCNA, SELE
10	iron32 18	15.7	RECK, SERPINA1, SERPINA3, VIM, UROD, BCO2
11	5fluorouracil32	14.4	PIK3CA, PIK3CG, KIT, PCNA, RB1, RBL1
12	superoxide32 18	15.3	PIK3CA, SFN, RB1, SELL, SERPINA3, BIRC5
13	wortmannin32 42	15.1	PIK3CA, PIK3CG, VIM, BRAF, RAF1, BIRC5
14	butyrate32	13.9	PCNA, RB1, VIM, VDR, MYC, BMP6
15	actinomycin d32	13.8	PIK3CA, PIK3CG, KIT, RB1, SELE, VIM
16	etoposide32 42 9 9	16.5	PIK3CA, PIK3CG, RECK, PCNA, RB1, SELE
17	p00232	13.5	KIT, RB1, SERPINB5, BRAF, BIRC5, MTHFR
18	h2o232	13.2	PIK3CG, SELL, SERPINA1, NAT1, BCL2L11, LGALS3
19	aspirin32 34 18	15.1	PCNA, SELE, SELL, SERPINB5, VDR, BMP6
20	agar32	13.1	PIK3CA, RB1, VIM, BRAF, RARA, RARB
21	lysine32	12.9	RECK, SET, SERPINA1, UROD, SCT, CHKA
22	dopamine32 9 18 9	15.7	PIK3CA, PICK1, NCAM1, SELE, SERPINA3, BMP6
23	pge232	12.6	SELE, RAF1, SCT, MUC5AC, CGB5, CD14
24	ly29400232	12.5	PIK3CA, PIK3CG, SELE, VEGFA, RARA, MUC2
25	5-aza-2deoxycytidine32	12.3	PCNA, SERPINB5, VIM, MYC, BMP6, RARB
26	fmlp32	12.3	PIK3CG, SELL, SERPINA3, VIM, LCN2, FUT4
27	nmda32 42	13.3	PIK3CA, PICK1, NCAM1, VIM, BCL2L1, CDK5
28	quercetin32 42 9 18 9	16.2	PIK3CA, PIK3CG, SELE, RAF1, BIRC5, PARP1
29	ag 147832	12.0	PIK3CA, PIK3CG, RAF1, MUC5AC, BAK1, CDKN1B
30	dutp32	11.9	PCNA, BIRC5, PARP1, BCL2, BCL2L1, LGALS3
31	mifepristone32 42 9 9	14.9	BIRC5, BCL2L1, MUC1, BAX, CGB, CGB5
32	geldanamycin32 9 9	13.8	PIK3CG, BRAF, VEGFA, RAF1, BIRC5, PARP1
33	phosphatidylserine32 9 9	13.8	RECK, SELE, VIM, BID, PARP1, BCL2
34	ceramide32	11.8	PIK3CA, RB1, RAF1, BID, PAWR, BCL2L1
35	phosphatidylcholine32	11.8	SELE, VIM, RAF1, CHKA, MUC5AC, MTTP
36	flavopiridol32 9 9	13.7	PIK3CG, KIT, RB1, RBL1, VEGFA, BID
37	aprotinin32 9 9	13.6	MMP2, MMP9, FGA, MB, MAP2K1, IGFBP5
38	cytosine32 18	12.6	SERPINB5, RASSF1, ATRX, CDH1, APC, MBD2
39	daunorubicin32 9 9	13.6	MYC, RAF1, BIRC5, BCL2, BCL2L1, BAX
40	suramin32 9 9	13.6	NCAM1, RECK, PCNA, VEGFA, BMP6, RAF1
41	melphalan32 9 9	13.6	BIRC5, BCL2L1, BCL2L11, CHKB, MMP2, GSTP1
42	rapamycin32 42	12.6	PIK3CG, KIT, RB1, SELL, VIM, BRAF
43	carboplatin32 34 9 9	14.4	RB1, VEGFA, BID, PARP1, KDR, BCL2
44	herbimycin a32 42	12.2	PIK3CG, SELE, SELL, MYC, BMP6, RAF1
45	phenobarbital32 9 9	13.2	PCNA, MYC, UROD, GPT, ALPP, HNF4A
46	rottlerin32 42	12.2	PIK3CG, PARP1, GRP, IL6R, MCL1, MAPK14
47	noxa32	11.0	BID, BIRC5, BCL2, BCL2L1, BCL2L11, BAK1
48	thapsigargin32 42	12.0	PIK3CG, PCNA, RAF1, BCL2, BCL2L1, BAK1
49	azathioprine32 34 9 9	13.8	PCNA, VIM, RARB, RASSF1, CHKB, MUC2
50	c2ceramide32	10.8	PIK3CG, PARP1, BCL2L1, BAX, CGB5, MAPK14

Cellular components related to cholangiocarcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	25.1	ZNF569, ZNF205, ZNF219, ZNF792, ZNF189, LRRC16A
2	cytoplasm	GO:005737	24.4	PICK1, PIK3CG, LRRC26, LRRC16A, KLHL20, PDCD4
3	cytosol	GO:005829	19.5	PIK3CA, PIK3CG, LRRC16A, PDCD4, CNOT1, PCM1
4	plasma membrane	GO:005886	18.2	PICK1, PIK3CG, NCAM1, RECK, KIT, SELE
5	extracellular region	GO:005576	16.3	NCAM1, SERPINA1, SERPINA3, VEGFA, VEGFC, CLSTN1
6	mitochondrion	GO:005739	15.2	PICK1, BSG, BID, CLTC, PARL, BCL2
7	extracellular space	GO:005615	15.0	KIT, SFN, SELE, SERPINB5, SERPINA1, VEGFA
8	nucleoplasm	GO:005654	14.2	KIF20B, PCNA, RB1, RBL1, SET, VDR
9	perinuclear region of cytoplasm	GO:048471	12.9	PICK1, KLHL20, SELE, SET, BCL10, MT3
10	Golgi lumen	GO:005796	12.3	MUC1, MUC17, MUC2, MUC3A, MUC4, MUC5AC
11	protein complex	GO:043234	12.0	PICK1, SET, MYC, BCL10, CDKN2A, CD63
12	cell surface	GO:009986	11.5	KLHL20, NCAM1, VEGFA, RARA, USP14, LGALS1
13	platelet alpha granule lumen	GO:031093	11.5	SERPINA1, VEGFA, VEGFC, FGA, F5, ALB

Biological processes related to cholangiocarcinoma according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	16.4	PIK3CA, PIK3CG, GCLM, BSG, NADSYN1, NAT1
2	cellular protein metabolic process	GO:044267	14.9	MUC1, MUC17, MUC2, MUC3A, MUC4, MUC5AC
3	apoptotic process	GO:006915	13.7	PDCD4, SFN, VIM, BRMS1, BMF, RAF1
4	blood coagulation	GO:007596	13.1	PIK3CA, PIK3CG, LRRC16A, SELL, SERPINA1, BSG
5	response to drug	GO:042493	12.9	GCLM, VEGFC, MYC, BCL2, LGALS1, BAK1
6	gene expression	GO:010467	12.8	CNOT1, RBL1, SET, VDR, MYC, RARA
7	cell proliferation	GO:008283	12.5	SFN, PCNA, RAF1, BCL2L1, CKS1B, BAK1
8	anti-apoptosis	GO:006916	12.4	PIK3CA, BRAF, BIRC5, BCL2, BCL2L1, MUC1
9	signal transduction	GO:007165	12.4	KIT, SFN, VEGFC, VDR, RARA, RARB
10	virus-host interaction	GO:019048	12.3	RB1, RBL1, VIM, KDR, BAX, CFLAR
11	negative regulation of apoptotic process	GO:043066	12.3	PIK3CG, KLHL20, BRAF, VEGFA, MYC, RAF1
12	positive regulation of apoptotic process	GO:043065	12.2	RARB, RAD9A, BID, PAWR, BCL2L11, UBD
13	negative regulation of cell proliferation	GO:008285	12.2	SFN, VDR, RARB, RAF1, RARRES3, CLMN
14	platelet activation	GO:030168	12.1	PIK3CA, PIK3CG, SERPINA1, VEGFA, VEGFC, RAF1
15	cell cycle arrest	GO:007050	12.1	KIF20B, RB1, MYC, RASSF1, MSH2, CDKN2B
16	response to hypoxia	GO:001666	11.9	SERPINA1, VEGFA, RAF1, BCL2, MT3, CD24
17	platelet degranulation	GO:002576	11.8	SERPINA1, VEGFA, VEGFC, CD63, FGA, F5
18	response to organic cyclic compound	GO:014070	11.8	SERPINA1, BAK1, MSH2, MET, ANXA1, CCND1
19	organ regeneration	GO:031100	11.8	BAAT, BAK1, MKI67, CCND1, CCKAR, F7
20	digestion	GO:007586	11.7	SCTR, MUC3A, MUC5AC, CCKBR, CCKAR, AKR1C1
21	negative regulation of neuron apoptotic process	GO:043524	11.7	GCLM, SET, BRAF, BCL2, BCL2L1, BAX
22	protein autophosphorylation	GO:046777	11.5	KIT, CLK4, KDR, MTOR, AURKA, CDK5
23	positive regulation of cell migration	GO:030335	11.5	VEGFA, KDR, MMP14, ILK, APC, MAP2K1
24	response to lipopolysaccharide	GO:032496	11.4	SELE, SERPINA1, BDKRB1, MMP9, IL18BP, FASLG
25	induction of apoptosis	GO:006917	11.4	PAWR, BCL10, BCL2L11, CIDEB, BAX, CDKN1B
26	induction of apoptosis by intracellular signals	GO:008629	11.3	MYC, BMF, BID, BCL2, BCL2L1, BCL2L11
27	response to estradiol stimulus	GO:032355	11.3	SERPINA1, VDR, RARA, BID, AURKA, MMP9
28	activation of pro-apoptotic gene products	GO:008633	11.3	MYC, BMF, BID, BCL2, BCL2L11, BAK1
29	response to cytokine stimulus	GO:034097	11.2	SERPINA1, BCL2, BCL2L1, IL6R, IL6ST, MCL1
30	positive regulation of protein kinase B signaling cascade	GO:051897	11.1	PIK3CG, MTOR, ILK, IGFBP5, F7, F3
31	release of cytochrome c from mitochondria	GO:001836	11.1	SFN, MYC, BID, BCL2, BCL2L1, BAK1
32	epidermal growth factor receptor signaling pathway	GO:007173	11.1	PIK3CA, RAF1, CLTC, UBA52, MTOR, CDKN1B
33	nerve growth factor receptor signaling pathway	GO:048011	11.1	PIK3CA, BRAF, RAF1, CLTC, ZFYVE27, BCL2L11
34	positive regulation of cell proliferation	GO:008284	11.1	KIT, VEGFA, VEGFC, MYC, RARA, BLOC1S2
35	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.1	MYC, BCL2L11, BAX, CDKN1B, CDKN2A, FASLG
36	striated muscle cell differentiation	GO:051146	11.0	RB1, CDH2, MAPK14, IGFBP5, HRAS, AKT1
37	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:043154	11.0	SFN, VEGFA, RAF1, BIRC5, MT3, CD44
38	response to glucocorticoid stimulus	GO:051384	11.0	IL6, FAS, MAP2K1, CCKAR, ALPL, TNF
39	positive regulation of protein phosphorylation	GO:001934	10.9	VEGFA, MT3, MTOR, FLT4, MAPK3, CCND1
40	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.9	KIT, KDR, FLT3, F2, F2R, F2RL1
41	fibroblast growth factor receptor signaling pathway	GO:008543	10.9	PIK3CA, BRAF, RAF1, UBA52, MTOR, CDKN1B
42	angiogenesis	GO:001525	10.9	PIK3CA, PIK3CG, VEGFA, VEGFC, KDR, MMP2
43	phosphatidylinositol-mediated signaling	GO:048015	10.8	PIK3CA, PCNA, UBE2C, MTOR, AURKA, CDKN1B
44	aging	GO:007568	10.8	VDR, BAK1, FAS, F3, CASP7, PTGS1
45	regulation of apoptotic process	GO:042981	10.7	KIAA1324, RAF1, BLOC1S2, BIRC5, LGALS1, UBA52
46	positive regulation of MAP kinase activity	GO:043406	10.7	PIK3CG, VEGFA, CD24, FLT3, ILK, AJUBA
47	positive regulation of endothelial cell proliferation	GO:001938	10.6	VEGFA, BMP6, KDR, MTOR, FLT4, ANG
48	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.6	BRAF, KDR, MT3, CD44, FLT4, MAPK3
49	activation of MAPKK activity	GO:000186	10.5	RAF1, MAP2K2, F2R, NRAS
50	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.4	VEGFA, VEGFC, KDR, FLT4, MAPK14, NRP1

Molecular functions related to cholangiocarcinoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	31.3	KRT8, CTNNB1, CTNNBL1, CTNND1, CTSB, PPIA
2	ATP binding	GO:005524	13.4	SRC, OAS1, PDGFRA, PDGFRB, C10orf2, EGFR
3	protein homodimerization activity	GO:042803	12.9	ABCG2, PDGFRA, PDGFB, NOS2, SMAD4, PTGS2
4	identical protein binding	GO:042802	12.3	TP63, TP53, ERBB2, AKT1, ALDOA, IGF1R
5	enzyme binding	GO:019899	12.1	PPARG, CTNNBL1, CTNNB1, CUTA, CYP1A2, CYB5A
6	receptor binding	GO:005102	11.7	CTNND1, SRC, TNFSF10, HLA-B, HNF4A, NOS2
7	growth factor activity	GO:008083	11.5	TGFB1, TFF1, CXCL1, CXCL12, NUDT6, CSF3
8	vascular endothelial growth factor-activated receptor activity	GO:005021	10.0	PDGFRB, PDGFRA, NRP1, FLT3, FLT4, KDR