CCA
MCID: CHL065
MIFTS: 61

Cholangiocarcinoma (CCA) malady

Liver, Cancer categories

Summaries for Cholangiocarcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial... more...

MalaCards: Cholangiocarcinoma, also known as adult primary cholangiocellular carcinoma, is related to hepatitis c and adenocarcinoma, and has symptoms including hepatitis/icterus/cholestasis, abnormal colour of the urine/cholic/dark urines and extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer. An important gene associated with Cholangiocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The compounds paraffin and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Cholangiocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
cholangiocarcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

cholangiocarcinoma 8 10 45 49 61
adult primary cholangiocellular carcinoma 8 61
adult primary cholangiocarcinoma 8
bile duct carcinoma 61
bile duct cancer 49
cholangiosarcoma 8
cca 49


External Ids:

Disease Ontology8 DOID:4947
MeSH35 D018281
NCIt40 C4436
MESH via Orphanet36 D018281, D001650
SNOMED-CT57 70179006, 312104005
ICD10 via Orphanet26 C22.1
SNOMED-CT via Orphanet58 312104005, 70179006
UMLS via Orphanet62 C0206698, C0740277

Related Diseases for Cholangiocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cholangiocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 264)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.0AFP, TIMP3
2adenocarcinoma30.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
3bladder carcinoma30.5KRT20, KRT19, MUC2, MAGEA3
4viral hepatitis30.4AFP
5adenoma30.4CEACAM3, LGALS3, KRT20, KRT7, KRT19, MCL1
6pancreatic ductal carcinoma30.2KRT20, KRT7, MUC5AC, MUC2
7pancreatitis, chronic30.2CEACAM3, MUC4, MUC5AC, MUC2
8biliary papillomatosis30.2MUC2
9biliary tract cancer30.1MUC4, MET
10bile duct carcinoma30.1CEACAM3, MAGEA3
11squamous cell carcinoma30.0CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
12colorectal cancer30.0CEACAM3, LGALS3, KRT20, KRT7, CFLAR, CDKN1B
13primary biliary cirrhosis30.0KRT7, KRT19, MCL1
14hepatitis b30.0AFP
15papillary carcinoma29.8CEACAM3, LGALS3, KRT20, KRT7, KRT19, CDKN1B
16neuroendocrine carcinoma29.8KRT20, KRT7, KRT19, CDX2, MUC1
17cystadenoma29.8CEACAM3, KRT7, VEGFC
18bile duct adenoma29.8KRT7, KRT19
19spindle cell sarcoma29.8KRT7, MUC1
20sclerosing cholangitis10.7
21primary sclerosing cholangitis10.7
22hepatitis c virus10.6
23opisthorchiasis10.5
24bile duct carcinoma in situ10.5
25congenital contractural arachnodactyly10.4
26adenosquamous bile duct carcinoma10.4
27squamous cell bile duct carcinoma10.4
28hepatitis e10.4
29clonorchiasis10.4
30choledochal cyst10.4
31hepatitis a10.4
32hepatitis d10.3
33bile duct adenocarcinoma10.3
34extrahepatic bile duct small cell adenocarcinoma10.3
35sarcomatous intrahepatic cholangiocarcinoma10.3
36intestinal schistosomiasis10.3
37whiplash10.3
38urinary schistosomiasis10.2
39ascariasis10.2
40hypercalcemia10.2
41klatskin's tumor10.2
42common bile duct neoplasm10.2
43mucinous adenocarcinoma10.2
44bile duct mucinous adenocarcinoma10.2
45bone carcinoma10.2
46cholecystolithiasis10.2
47liver carcinoma in situ10.2
48bile duct cysts10.2
49inflammatory myofibroblastic tumor10.2
50ileus10.2

Graphical network of the top 20 diseases related to Cholangiocarcinoma:



Diseases related to cholangiocarcinoma

Clinical Features for Cholangiocarcinoma

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 9)
  • hepatitis/icterus/cholestasis
  • abnormal colour of the urine/cholic/dark urines
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • pruritus/itching
  • asthenia/fatigue/weakness
  • acute abdominal pain/colic
  • anorexia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling

Drugs & Therapeutics for Cholangiocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cholangiocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cholangiocarcinoma

Search NIH Clinical Center for Cholangiocarcinoma

Search CenterWatch for Cholangiocarcinoma

Genetic Tests for Cholangiocarcinoma

Anatomical Context for Cholangiocarcinoma

Animal Models for Cholangiocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Cholangiocarcinoma

Sources:
51PubMed
See all sources

Articles related to Cholangiocarcinoma:

(show top 50)    (show all 1420)
idTitleAuthorsYear
1
Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan. (24420816)
2014
2
Aberrant expression of laminin I^2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma. (24124977)
2014
3
Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma? A literature review. (23979207)
2013
4
Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma. (24049014)
2013
5
Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9. (23446431)
2013
6
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
7
Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma. (23588885)
2013
8
High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery. (23132676)
2013
9
Three-dimensional Computed Tomographic Cholangiography as a Novel Diagnostic Tool for Evaluation of Bile Duct Invasion of Perihilar Cholangiocarcinoma. (24025264)
2013
10
Stage of hilar cholangiocarcinoma predicts recurrence of biliaryA obstruction in patients with metal stents. (23811239)
2013
11
High serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case-control study. (23760942)
2013
12
Determination of Chemical Composition of Gallbladder Stones and their Association with Induction of Cholangiocarcinoma. (24377514)
2013
13
Photodynamic therapy in unresectable cholangiocarcinoma: not for the uncommitted. (23964337)
2013
14
Advances in liver surgery for cholangiocarcinoma. (23563982)
2013
15
Cholangiocarcinoma developed in a patient with IgG4-related disease. (24009815)
2013
16
MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis. (23621247)
2013
17
Liver transplantation for perihilar cholangiocarcinoma. (23797134)
2013
18
Differentiating combined hepatocellular and cholangiocarcinoma from mass-forming intrahepatic cholangiocarcinoma using gadoxetic acid-enhanced MRI. (22730271)
2012
19
Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and UroVysiona8c fluorescent in situ hybridization. (22431323)
2012
20
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma. (22446018)
2012
21
Photodynamic therapy in cholangiocarcinoma. (23055215)
2012
22
Transarterial chemoembolization versus supportive therapy in the palliative treatment of unresectable intrahepatic cholangiocarcinoma. (21356394)
2011
23
Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma. (21674559)
2011
24
Many patients with primary sclerosing cholangitis and increased serum levels of carbohydrate antigen 19-9 do not have cholangiocarcinoma. (21334457)
2011
25
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
26
Yttrium-90 radiotherapy for unresectable intrahepatic cholangiocarcinoma: a preliminary assessment of this novel treatment option. (19876691)
2010
27
Surgery and chemotherapy for intrahepatic cholangiocarcinoma. (21160974)
2010
28
DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma. (20720444)
2010
29
Survival analysis of intrahepatic cholangiocarcinoma after resection. (20165987)
2010
30
p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. (19816939)
2010
31
Overexpression of adenovirus-mediated p27kip1 lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth. (19528460)
2009
32
Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification. (19212186)
2009
33
Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. (19621664)
2009
34
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. (18624901)
2008
35
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis. (18397431)
2008
36
Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. (18580211)
2008
37
An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas. (17239935)
2007
38
Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas. (17550320)
2007
39
Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. (17329257)
2007
40
MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma. (16124042)
2005
41
Inactivation of RASSF1A, the tumor suppressor gene at 3p21.3 in extrahepatic cholangiocarcinoma. (15761971)
2005
42
Cholangiocarcinoma in the distal bile duct: a probable etiologic association with choledocholithiasis. (16240231)
2005
43
Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma. (15742394)
2005
44
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. (16024633)
2005
45
A case of combined hepatocellular-cholangiocarcinoma with sarcomatous transformation and second primary colon cancer]. (15218348)
2004
46
Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. (11910351)
2002
47
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. (10212000)
1999
48
Immunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis. (9490278)
1998
49
Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinoma. (9762547)
1998
50
Methods in pathology. p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue sections. (8008749)
1994

Genetic Variations for Cholangiocarcinoma

Expression for genes affiliated with Cholangiocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangiocarcinoma

Search GEO for disease gene expression data for Cholangiocarcinoma.

Pathways for genes affiliated with Cholangiocarcinoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Cholangiocarcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Cholangiocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1paraffin4513.6TIMP3, CEACAM3, HGF, MET, VEGFC, MAGEA3
2tyrosine4513.6KRT20, KRT7, KRT19, CFLAR, MCL1, CDKN1B
3progesterone45 60 29 11 2417.3TIMP3, MET, AFP, VEGFC, CEACAM3, LGALS3
4retinoic acid45 2414.3TIMP3, HGF, MET, AFP, VEGFC, MUC2
5calcium45 50 11 2416.3MUC2, MUC5AC, MUC1, MUC4, CDX2, CFLAR
6oligonucleotide4513.2AFP, MET, OGG1, TIMP3, MCL1, CDKN1B
7oxygen45 2414.2TIMP3, HGF, OGG1, MET, AFP, VEGFC
8vegf4513.2KRT20, KRT7, LGALS3, CEACAM3, KRT19, CFLAR
9testosterone45 60 11 2415.8KRT7, AFP, CFLAR, MUC1, HGF, VEGFC
10thymidine45 2413.7CEACAM3, VEGFC, AFP, MET, HGF, OGG1
11glucose4512.7KRT19, MET, TIMP3, CEACAM3, KRT7, MUC2
12phosphatidylinositol4512.5CFLAR, MCL1, CDKN1B, MUC4, MUC5AC, VEGFC
135fluorouracil4512.3MUC5AC, CFLAR, MCL1, CDKN1B, MUC1, CEACAM3
14matrigel4512.3KRT7, KRT19, MUC4, MUC1, VEGFC, MET
15lipid4512.3MCL1, MUC1, VEGFC, CFLAR, AFP, KRT7
16pd 98,0594512.3MCL1, CDKN1B, MUC5AC, MUC2, VEGFC, MET
17glycogen45 2413.3MET, AFP, MUC1, HGF, MCL1, KRT19
18cisplatin45 50 60 1115.3MCL1, CDKN1B, LGALS3, KRT19, CFLAR, MUC1
19dexamethasone45 50 29 1115.3MCL1, CDKN1B, MUC4, MUC5AC, MUC2, AFP
20nitric oxide45 11 2414.2LGALS3, CEACAM3, CFLAR, MUC1, MUC5AC, MET
21threonine4512.2LGALS3, CFLAR, CDKN1B, MUC1, MUC5AC, MCL1
22hematoxylin4512.2MUC5AC, MUC2, KRT20, LGALS3, CEACAM3, MUC1
23methotrexate45 50 1114.2KRT7, CDKN1B, MUC1, MUC5AC, AFP, MUC2
24ly2940024512.1MUC2, CFLAR, VEGFC, MET, HGF, CDKN1B
25actinomycin d4512.1HGF, CFLAR, MCL1, CDKN1B, MET, AFP
26cysteine4512.1LGALS3, MET, MUC2, MUC5AC, CFLAR, MUC1
27cholesterol45 29 11 2415.0AFP, MET, MUC2, MUC5AC, MUC4, CDKN1B
28dmso4512.0HGF, MUC1, CDKN1B, MUC5AC, MUC2, AFP
29steroid4512.0CEACAM3, TIMP3, MET, MUC4, CDX2, KRT19
30ribonucleic acid4511.9KRT19, VEGFC, MET, MUC5AC, TIMP3, KRT20
3112-o-tetradecanoylphorbol 13-acetate4511.9HGF, TIMP3, MCL1, CDKN1B, MUC1, MUC2
32wortmannin4511.9TIMP3, LGALS3, CFLAR, CDKN1B, MET, MCL1
33doxorubicin45 50 1113.9CDKN1B, AFP, CFLAR, KRT20, CEACAM3, HGF
34adriamycin4511.9CEACAM3, CFLAR, AFP, MUC1, HGF, OGG1
35b 7234511.9KRT20, KRT19, AFP, CEACAM3, KRT7, MUC1
36serine4511.8MUC5AC, MUC2, AFP, CDKN1B, CFLAR, KRT19
37formaldehyde45 2412.7KRT19, CDKN1B, MUC1, KRT7, KRT20, LGALS3
38agar4511.7LGALS3, CDKN1B, MET, HGF, AFP, MUC1
39etoposide45 50 60 1114.6CDKN1B, MCL1, LGALS3, HGF, AFP, CFLAR
40estradiol45 11 2413.5CFLAR, VEGFC, AFP, TIMP3
41polysaccharide4511.4AFP, LGALS3, KRT7, MUC1, MUC5AC, HGF
42mucicarmine4511.4MUC1, KRT7, KRT20, CEACAM3
43paclitaxel45 50 1113.3HGF, CDKN1B, MCL1, CFLAR, KRT19, AFP
44carbohydrates4511.3KRT19, MUC5AC, MUC2
45sialic acid4511.2CEACAM3, KRT7
46butyrate4511.2MCL1, CDX2
47trastuzumab45 50 1113.1CDKN1B, MUC4, MUC1, VEGFC
48galactose4511.1CEACAM3, LGALS3, MUC2
49heparin45 29 11 2414.0CDKN1B, AFP, TIMP3
505-aza-2deoxycytidine4511.0CDX2, KRT7, CFLAR, MUC2, TIMP3

GO Terms for genes affiliated with Cholangiocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588211.0KRT20, KRT7, KRT19
2Golgi lumenGO:00579610.8MUC4, MUC1, MUC5AC, MUC2

Biological processes related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:01626611.2MUC4, MUC1, MUC5AC, MUC2
2post-translational protein modificationGO:04368711.1MUC4, MUC1, MUC5AC, MUC2
3negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.8MET, HGF
4myoblast proliferationGO:05145010.7HGF, MET
5regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.5MET, HGF

Molecular functions related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.9LGALS3, HGF, OGG1, MET, VEGFC, MAGEA3

Products for genes affiliated with Cholangiocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholangiocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet