CCA
MCID: CHL065
MIFTS: 73

Cholangiocarcinoma (CCA) malady

Liver diseases, Cancer diseases categories

Summaries for Cholangiocarcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

MalaCards: Cholangiocarcinoma, also known as adult primary cholangiocellular carcinoma, is related to hepatocellular carcinoma and hepatitis, and has symptoms including fever/chilling, hepatitis/icterus/cholestasis and pruritus/itching. An important gene associated with Cholangiocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The compounds paraffin and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and lymph node, and related mouse phenotypes are mortality/aging and cellular.

Description from OMIM:46 615619

Aliases & Classifications for Cholangiocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
cholangiocarcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

cholangiocarcinoma 8 10 44 48 46 60
adult primary cholangiocellular carcinoma 8 60
adult primary cholangiocarcinoma 8
bile duct carcinoma 60
bile duct cancer 48
cholangiosarcoma 8
cca 48


External Ids:

Disease Ontology8 DOID:4947
MeSH34 D018281
NCIt39 C4436
MESH via Orphanet35 D018281, D001650
SNOMED-CT56 70179006, 312104005
ICD10 via Orphanet26 C22.1
SNOMED-CT via Orphanet57 312104005, 70179006
UMLS via Orphanet61 C0206698, C0740277
OMIM46 615619

Related Diseases for Cholangiocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cholangiocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 283)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma31.2CEACAM3, KRT7, KRT19, CFLAR, MCL1, CDKN1B
2hepatitis31.2AFP, HGF
3hepatitis b30.7AFP
4adenocarcinoma30.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
5hepatitis c30.5AFP, TIMP3
6gallbladder cancer30.5CEACAM3, KRT7, CDKN1B, CDX2, MUC5AC, MUC2
7bladder carcinoma30.4KRT20, KRT19, MUC2, MAGEA3
8viral hepatitis30.4AFP
9adenoma30.3CEACAM3, LGALS3, KRT20, KRT7, KRT19, MCL1
10liver cirrhosis30.2AFP, HGF
11gastric adenocarcinoma30.2KRT20, KRT7, CFLAR, MCL1, CDX2, MUC4
12biliary papillomatosis30.2MUC2
13colon adenocarcinoma30.1LGALS3, KRT20, CFLAR, CDKN1B, MUC5AC, MUC2
14squamous cell carcinoma30.0CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
15colorectal cancer30.0CEACAM3, LGALS3, KRT20, KRT7, CFLAR, CDKN1B
16colon cancer30.0CEACAM3, LGALS3, KRT20, KRT19, CFLAR, CDKN1B
17primary biliary cirrhosis29.9KRT7, KRT19, MCL1
18bile duct carcinoma29.9CEACAM3, MAGEA3
19breast cancer29.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, MCL1
20lung cancer29.7CEACAM3, KRT20, KRT7, KRT19, CDX2, MUC4
21melanoma29.7CEACAM3, LGALS3, CFLAR, MCL1, CDKN1B, CDX2
22papillary carcinoma29.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, CDKN1B
23pancreatic cancer29.7CEACAM3, LGALS3, KRT19, CDX2, MUC4, MUC1
24neuroendocrine carcinoma29.7KRT20, KRT7, KRT19, CDX2, MUC1
25sarcoma29.7CFLAR, MUC1, MAGEA3, MET
26cystadenocarcinoma29.7CEACAM3, MUC1, MUC5AC, MUC2
27cystadenoma29.7CEACAM3, KRT7, VEGFC
28non-hodgkin lymphoma29.7CFLAR, MCL1, CDKN1B, OGG1
29bile duct adenoma29.7KRT7, KRT19
30inflammatory bowel disease29.7MUC2
31spindle cell sarcoma29.7KRT7, MUC1
32lung squamous cell carcinoma29.7KRT19, TIMP3
33intrahepatic cholangiocarcinoma11.2
34cholangitis10.7
35sclerosing cholangitis10.7
36hepatitis a10.5
37bile duct carcinoma in situ10.5
38opisthorchiasis10.4
39pancreatitis10.4
40congenital contractural arachnodactyly10.4
41adenosquamous bile duct carcinoma10.4
42squamous cell bile duct carcinoma10.4
43mucinous intrahepatic cholangiocarcinoma10.4
44clonorchiasis10.4
45choledochal cyst10.3
46schistosomiasis10.3
47extrahepatic bile duct small cell adenocarcinoma10.3
48extrahepatic bile duct adenocarcinoma10.3
49bile duct adenocarcinoma10.3
50sarcomatous intrahepatic cholangiocarcinoma10.2

Graphical network of the top 20 diseases related to Cholangiocarcinoma:



Diseases related to cholangiocarcinoma

Clinical Features for Cholangiocarcinoma

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

615619

Symptoms:

48 (show all 9)
  • fever/chilling
  • hepatitis/icterus/cholestasis
  • pruritus/itching
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • anorexia
  • abnormal colour of the urine/cholic/dark urines
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • asthenia/fatigue/weakness

Drugs & Therapeutics for Cholangiocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholangiocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cholangiocarcinoma

Search NIH Clinical Center for Cholangiocarcinoma

Search CenterWatch for Cholangiocarcinoma

Genetic Tests for Cholangiocarcinoma

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Anatomical Context for Cholangiocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Cholangiocarcinoma:

32
Liver, Small intestine, Lymph node, Colon, Endothelial, Brain, T cells, Kidney, Thyroid, Ovary, Skeletal muscle, Testis, Monocytes, Pancreas, Breast, Prostate, Myeloid, Lung, Fetal liver, Testes

Animal Models for Cholangiocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholangiocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7AFP, MET, OGG1, HGF, TIMP3, VEGFC
2MP:000538412.6MUC2, MET, OGG1, HGF, TIMP3, CDX2
3MP:000538512.2TIMP3, HGF, MET, VEGFC, MUC2, CDX2
4MP:000538712.0TIMP3, OGG1, MET, VEGFC, MUC2, MUC5AC
5MP:000538111.8MET, MUC2, MUC5AC, MUC1, CDX2, CDKN1B
6MP:000539711.8HGF, OGG1, MUC2, CDKN1B, MCL1, CFLAR
7MP:000200611.5KRT19, CDKN1B, MUC2, AFP, MET
8MP:000537611.4TIMP3, AFP, MUC2, MUC5AC, CDX2
9MP:000537911.3AFP, MUC2, CDX2, CDKN1B, KRT19
10MP:000537011.1TIMP3, HGF, OGG1, MET, MUC1, CDKN1B

Publications for Cholangiocarcinoma

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Sources:
50PubMed
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Articles related to Cholangiocarcinoma:

(show top 50)    (show all 1419)
idTitleAuthorsYear
1
Utility of immunocytochemistry in diagnosing leptomeningeal metastases from an intrahepatic cholangiocarcinoma. (23341095)
2014
2
Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. (24304591)
2013
3
The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma. (23688168)
2013
4
Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. (23772655)
2013
5
Left hepatic trisectionectomy for advanced perihilar cholangiocarcinoma. (23460314)
2013
6
Aberrant expression of GATA binding protein 6 correlates with poor prognosis and promotes metastasis in cholangiocarcinoma. (23313142)
2013
7
BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma. (24309328)
2013
8
Gross pathological classification of peripheral cholangiocarcinoma determines the efficacy of hepatectomy. (23001251)
2013
9
Distal Cholangiocarcinoma: Prognostic Factors after Curative Surgery. A Series of 84 Cases. (24025267)
2013
10
Transumbilical single-incision laparoscopic hepatectomy using precoagulation and clipless technique in a patient with combined hepatocellular-cholangiocarcinoma: a case report. (24105295)
2013
11
Two cases of humoral hypercalcemia of malignancy in metastatic cholangiocarcinoma. (23864848)
2013
12
Improvement of serum alkaline phosphatase to <1.5 upper limit of normal predicts better outcome and reduced risk of cholangiocarcinoma in primary sclerosing cholangitis. (23085647)
2013
13
Cholecystoduodenal drainage and gallstone removal in a patient with cholecystitis and unresectable cholangiocarcinoma. (23716085)
2013
14
Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma. (23446751)
2013
15
Comparison between resection and transplantation in combined hepatocellular and cholangiocarcinoma. (24157032)
2013
16
Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway. (24038588)
2013
17
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
18
Potential role of peroral cholangioscopy for preoperative diagnosis of cholangiocarcinoma. (23238382)
2012
19
Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma. (23091390)
2012
20
Alteration of galectin-1 during tumorigenesis of Opisthorchis viverrini infection-induced cholangiocarcinoma and its correlation with clinicopathology. (22373585)
2012
21
Transarterial hepatic yttrium-90 radioembolization in patients with unresectable intrahepatic cholangiocarcinoma: factors associated with prolonged survival. (21431970)
2012
22
Cytologic features of fibrolamellar carcinoma with mucin production: A rare variant of combined hepatocellular-cholangiocarcinoma. (23008149)
2012
23
Expression of Smad7 in cholangiocarcinoma: prognostic significance and implications for tumor metastasis. (23244128)
2012
24
Overexpression of ECM1 contributes to migration and invasion in cholangiocarcinoma cell. (22489696)
2012
25
Comparative proteomic profiling of human bile reveals SSP411 as a novel biomarker of cholangiocarcinoma. (23118872)
2012
26
Liver-intestine cadherin in intraepithelial neoplasia of intrahepatic cholangiocarcinoma. (22024075)
2011
27
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma. (21451941)
2011
28
Distal cholangiocarcinoma with coexistent biliary ascariasis. (23024544)
2011
29
Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and inflammatory bowel disease. (21502832)
2011
30
Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. (21618579)
2011
31
Cholangiocarcinoma and paraneoplastic hypercalcemia: a lethal combination revisited. (20531035)
2010
32
Identification of cellular targets in human intrahepatic cholangiocarcinoma using laser microdissection and accurate mass and time tag proteomics. (20513801)
2010
33
Extensive endothelial replacement by tumor cells in the portal system: an autopsy case of intrahepatic cholangiocarcinoma. (20618738)
2010
34
MicroRNA profiling of human intrahepatic cholangiocarcinoma cell lines reveals biliary epithelial cell-specific microRNAs. (19755794)
2009
35
Enhancement patterns of intrahepatic cholangiocarcinoma: comparison between contrast-enhanced ultrasound and contrast-enhanced CT. (18941048)
2008
36
Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters. (18595142)
2008
37
Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor. (17458614)
2007
38
Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma. (16792547)
2006
39
Hepatocellular carcinoma and cholangiocarcinoma are associated with high serum levels of hepatocyte growth factor. (16974053)
2006
40
Intrahepatic cholangiocarcinoma associated with central calcification and arterio-portal shunt. (16157980)
2005
41
Cholangiocarcinoma presenting with severe gastroparesis and pseudoachalasia. (16204907)
2005
42
Percutaneous ultrasound-guided radiofrequency ablation of intrahepatic cholangiocarcinoma. (16089307)
2005
43
Major hepatic resection for hilar cholangiocarcinoma: analysis of 46 patients. (15136352)
2004
44
Intrahepatic cholangiocarcinoma diagnosed preoperatively as hepatocellular carcinoma. (15282700)
2004
45
Serum and bile markers for cholangiocarcinoma. (15192787)
2004
46
Intrahepatic cholangiocarcinoma masked as fever of unknown origin. (15036199)
2004
47
MRI of clonorchiasis and cholangiocarcinoma. (9562062)
1998
48
Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma. (8554130)
1996
49
Cholangiocarcinoma in a type III choledochal cyst. (1661112)
1991
50
Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type. (2467436)
1988

Genetic Variations for Cholangiocarcinoma

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Expression for genes affiliated with Cholangiocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangiocarcinoma

Search GEO for disease gene expression data for Cholangiocarcinoma.

Pathways for genes affiliated with Cholangiocarcinoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Cholangiocarcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Cholangiocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1paraffin4413.6TIMP3, CEACAM3, HGF, MET, VEGFC, MAGEA3
2tyrosine4413.6KRT20, KRT7, KRT19, CFLAR, MCL1, CDKN1B
3progesterone44 59 28 11 2417.3TIMP3, MET, AFP, VEGFC, CEACAM3, LGALS3
4retinoic acid44 2414.3TIMP3, HGF, MET, AFP, VEGFC, MUC2
5calcium44 49 11 2416.3MUC2, MUC5AC, MUC1, MUC4, CDX2, CFLAR
6oligonucleotide4413.2AFP, MET, OGG1, TIMP3, MCL1, CDKN1B
7oxygen44 2414.2TIMP3, HGF, OGG1, MET, AFP, VEGFC
8vegf4413.2KRT20, KRT7, LGALS3, CEACAM3, KRT19, CFLAR
9testosterone44 59 11 2415.8KRT7, AFP, CFLAR, MUC1, HGF, VEGFC
10thymidine44 2413.7CEACAM3, VEGFC, AFP, MET, HGF, OGG1
11glucose4412.7KRT19, MET, TIMP3, CEACAM3, KRT7, MUC2
12phosphatidylinositol4412.5CFLAR, MCL1, CDKN1B, MUC4, MUC5AC, VEGFC
135fluorouracil4412.3MUC5AC, CFLAR, MCL1, CDKN1B, MUC1, CEACAM3
14matrigel4412.3KRT7, KRT19, MUC4, MUC1, VEGFC, MET
15lipid4412.3MCL1, MUC1, VEGFC, CFLAR, AFP, KRT7
16pd 98,0594412.3MCL1, CDKN1B, MUC5AC, MUC2, VEGFC, MET
17glycogen44 2413.3MET, AFP, MUC1, HGF, MCL1, KRT19
18cisplatin44 49 59 1115.3MCL1, CDKN1B, LGALS3, KRT19, CFLAR, MUC1
19dexamethasone44 49 28 1115.3MCL1, CDKN1B, MUC4, MUC5AC, MUC2, AFP
20nitric oxide44 11 2414.2LGALS3, CEACAM3, CFLAR, MUC1, MUC5AC, MET
21threonine4412.2LGALS3, CFLAR, CDKN1B, MUC1, MUC5AC, MCL1
22hematoxylin4412.2MUC5AC, MUC2, KRT20, LGALS3, CEACAM3, MUC1
23methotrexate44 49 1114.2KRT7, CDKN1B, MUC1, MUC5AC, AFP, MUC2
24ly2940024412.1MUC2, CFLAR, VEGFC, MET, HGF, CDKN1B
25actinomycin d4412.1HGF, CFLAR, MCL1, CDKN1B, MET, AFP
26cysteine4412.1LGALS3, MET, MUC2, MUC5AC, CFLAR, MUC1
27cholesterol44 28 11 2415.0AFP, MET, MUC2, MUC5AC, MUC4, CDKN1B
28dmso4412.0HGF, MUC1, CDKN1B, MUC5AC, MUC2, AFP
29steroid4412.0CEACAM3, TIMP3, MET, MUC4, CDX2, KRT19
30ribonucleic acid4411.9KRT19, VEGFC, MET, MUC5AC, TIMP3, KRT20
3112-o-tetradecanoylphorbol 13-acetate4411.9HGF, TIMP3, MCL1, CDKN1B, MUC1, MUC2
32wortmannin4411.9TIMP3, LGALS3, CFLAR, CDKN1B, MET, MCL1
33doxorubicin44 49 1113.9CDKN1B, AFP, CFLAR, KRT20, CEACAM3, HGF
34adriamycin4411.9CEACAM3, CFLAR, AFP, MUC1, HGF, OGG1
35b 7234411.9KRT20, KRT19, AFP, CEACAM3, KRT7, MUC1
36serine4411.8MUC5AC, MUC2, AFP, CDKN1B, CFLAR, KRT19
37formaldehyde44 2412.7KRT19, CDKN1B, MUC1, KRT7, KRT20, LGALS3
38agar4411.7LGALS3, CDKN1B, MET, HGF, AFP, MUC1
39etoposide44 49 59 1114.6CDKN1B, MCL1, LGALS3, HGF, AFP, CFLAR
40estradiol44 11 2413.5CFLAR, VEGFC, AFP, TIMP3
41polysaccharide4411.4AFP, LGALS3, KRT7, MUC1, MUC5AC, HGF
42mucicarmine4411.4MUC1, KRT7, KRT20, CEACAM3
43paclitaxel44 49 1113.3HGF, CDKN1B, MCL1, CFLAR, KRT19, AFP
44carbohydrates4411.3KRT19, MUC5AC, MUC2
45sialic acid4411.2CEACAM3, KRT7
46butyrate4411.2MCL1, CDX2
47trastuzumab44 49 1113.1CDKN1B, MUC4, MUC1, VEGFC
48galactose4411.1CEACAM3, LGALS3, MUC2
49heparin44 28 11 2414.0CDKN1B, AFP, TIMP3
505-aza-2deoxycytidine4411.0CDX2, KRT7, CFLAR, MUC2, TIMP3

GO Terms for genes affiliated with Cholangiocarcinoma

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16Gene Ontology
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Cellular components related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588211.0KRT20, KRT7, KRT19
2Golgi lumenGO:00579610.8MUC4, MUC1, MUC5AC, MUC2

Biological processes related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:01626611.2MUC4, MUC1, MUC5AC, MUC2
2post-translational protein modificationGO:04368711.1MUC5AC, MUC1, MUC4, MUC2
3negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.8MET, HGF
4myoblast proliferationGO:05145010.7MET, HGF
5regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.5MET, HGF

Molecular functions related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.9LGALS3, HGF, OGG1, MET, VEGFC, MAGEA3

Products for genes affiliated with Cholangiocarcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholangiocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet