CCA
MCID: CHL065
MIFTS: 73

Cholangiocarcinoma (CCA) malady

Liver diseases, Cancer diseases categories

Summaries for Cholangiocarcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

MalaCards: Cholangiocarcinoma, also known as adult primary cholangiocellular carcinoma, is related to hepatocellular carcinoma and hepatitis, and has symptoms including fever/chilling, hepatitis/icterus/cholestasis and pruritus/itching. An important gene associated with Cholangiocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The compounds paraffin and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and lymph node, and related mouse phenotypes are mortality/aging and cellular.

Description from OMIM:46 615619

Aliases & Classifications for Cholangiocarcinoma

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Sources:
60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
cholangiocarcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

cholangiocarcinoma 8 10 44 48 46 60
adult primary cholangiocellular carcinoma 8 60
adult primary cholangiocarcinoma 8
bile duct carcinoma 60
cholangiosarcoma 8
bile duct cancer 48
cca 48


External Ids:

Disease Ontology8 DOID:4947
MeSH34 D018281
NCIt39 C4436
MESH via Orphanet35 D018281, D001650
SNOMED-CT56 70179006, 312104005
ICD10 via Orphanet26 C22.1
SNOMED-CT via Orphanet57 312104005, 70179006
UMLS via Orphanet61 C0206698, C0740277
OMIM46 615619

Related Diseases for Cholangiocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cholangiocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 283)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma31.2CEACAM3, KRT7, KRT19, CFLAR, MCL1, CDKN1B
2hepatitis31.2AFP, HGF
3hepatitis b30.7AFP
4adenocarcinoma30.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
5hepatitis c30.5AFP, TIMP3
6gallbladder cancer30.5CEACAM3, KRT7, CDKN1B, CDX2, MUC5AC, MUC2
7bladder carcinoma30.4KRT20, KRT19, MUC2, MAGEA3
8viral hepatitis30.4AFP
9adenoma30.3CEACAM3, LGALS3, KRT20, KRT7, KRT19, MCL1
10liver cirrhosis30.2AFP, HGF
11gastric adenocarcinoma30.2KRT20, KRT7, CFLAR, MCL1, CDX2, MUC4
12biliary papillomatosis30.2MUC2
13colon adenocarcinoma30.1LGALS3, KRT20, CFLAR, CDKN1B, MUC5AC, MUC2
14squamous cell carcinoma30.0CEACAM3, LGALS3, KRT20, KRT7, KRT19, CFLAR
15colorectal cancer30.0CEACAM3, LGALS3, KRT20, KRT7, CFLAR, CDKN1B
16colon cancer30.0CEACAM3, LGALS3, KRT20, KRT19, CFLAR, CDKN1B
17primary biliary cirrhosis29.9KRT7, KRT19, MCL1
18bile duct carcinoma29.9CEACAM3, MAGEA3
19breast cancer29.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, MCL1
20lung cancer29.7CEACAM3, KRT20, KRT7, KRT19, CDX2, MUC4
21melanoma29.7CEACAM3, LGALS3, CFLAR, MCL1, CDKN1B, CDX2
22papillary carcinoma29.7CEACAM3, LGALS3, KRT20, KRT7, KRT19, CDKN1B
23pancreatic cancer29.7CEACAM3, LGALS3, KRT19, CDX2, MUC4, MUC1
24neuroendocrine carcinoma29.7KRT20, KRT7, KRT19, CDX2, MUC1
25sarcoma29.7CFLAR, MUC1, MAGEA3, MET
26cystadenocarcinoma29.7CEACAM3, MUC1, MUC5AC, MUC2
27cystadenoma29.7CEACAM3, KRT7, VEGFC
28non-hodgkin lymphoma29.7CFLAR, MCL1, CDKN1B, OGG1
29bile duct adenoma29.7KRT7, KRT19
30inflammatory bowel disease29.7MUC2
31spindle cell sarcoma29.7KRT7, MUC1
32lung squamous cell carcinoma29.7KRT19, TIMP3
33intrahepatic cholangiocarcinoma11.2
34cholangitis10.7
35sclerosing cholangitis10.7
36hepatitis a10.5
37bile duct carcinoma in situ10.5
38opisthorchiasis10.4
39pancreatitis10.4
40congenital contractural arachnodactyly10.4
41adenosquamous bile duct carcinoma10.4
42squamous cell bile duct carcinoma10.4
43mucinous intrahepatic cholangiocarcinoma10.4
44clonorchiasis10.4
45choledochal cyst10.3
46schistosomiasis10.3
47extrahepatic bile duct small cell adenocarcinoma10.3
48extrahepatic bile duct adenocarcinoma10.3
49bile duct adenocarcinoma10.3
50sarcomatous intrahepatic cholangiocarcinoma10.2

Graphical network of the top 20 diseases related to Cholangiocarcinoma:



Diseases related to cholangiocarcinoma

Clinical Features for Cholangiocarcinoma

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

615619

Symptoms:

48 (show all 9)
  • fever/chilling
  • hepatitis/icterus/cholestasis
  • pruritus/itching
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • anorexia
  • abnormal colour of the urine/cholic/dark urines
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • asthenia/fatigue/weakness

Drugs & Therapeutics for Cholangiocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholangiocarcinoma

Drug clinical trials:

Search ClinicalTrials for Cholangiocarcinoma

Search NIH Clinical Center for Cholangiocarcinoma

Search CenterWatch for Cholangiocarcinoma

Genetic Tests for Cholangiocarcinoma

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Anatomical Context for Cholangiocarcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cholangiocarcinoma:

32
Liver, Small intestine, Lymph node, Colon, Endothelial, Brain, T cells, Kidney, Thyroid, Ovary, Skeletal muscle, Testis, Monocytes, Pancreas, Breast, Prostate, Myeloid, Lung, Fetal liver, Testes

Animal Models for Cholangiocarcinoma or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cholangiocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7AFP, MET, OGG1, HGF, TIMP3, VEGFC
2MP:000538412.6MUC2, MET, OGG1, HGF, TIMP3, CDX2
3MP:000538512.2TIMP3, HGF, MET, VEGFC, MUC2, CDX2
4MP:000538712.0TIMP3, OGG1, MET, VEGFC, MUC2, MUC5AC
5MP:000538111.8MET, MUC2, MUC5AC, MUC1, CDX2, CDKN1B
6MP:000539711.8HGF, OGG1, MUC2, CDKN1B, MCL1, CFLAR
7MP:000200611.5KRT19, CDKN1B, MUC2, AFP, MET
8MP:000537611.4TIMP3, AFP, MUC2, MUC5AC, CDX2
9MP:000537911.3AFP, MUC2, CDX2, CDKN1B, KRT19
10MP:000537011.1TIMP3, HGF, OGG1, MET, MUC1, CDKN1B

Publications for Cholangiocarcinoma

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Sources:
50PubMed
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Articles related to Cholangiocarcinoma:

(show top 50)    (show all 1419)
idTitleAuthorsYear
1
Hepatobiliary resection with concomitant resection of the inferior vena cava for advanced intrahepatic cholangiocarcinoma: report of a case. (22961194)
2013
2
Infiltration of peritumoural but tumour-free parenchyma with IgG4-positive plasma cells in hilar cholangiocarcinoma and pancreatic adenocarcinoma. (23602806)
2013
3
Gene expression profiling of intrahepatic cholangiocarcinoma. (23534794)
2013
4
TROP2 correlates with microvessel density and poor prognosis in hilar cholangiocarcinoma. (23207686)
2013
5
Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a review of the literature. (23824556)
2013
6
Catheter tract recurrence after percutaneous biliary drainage for hilar cholangiocarcinoma. (23430001)
2013
7
Asbestos: a hidden player behind the cholangiocarcinoma increase? Findings from a case-control analysis. (23408245)
2013
8
Prevalence of nonalcoholic steatohepatitis among patients with resectable intrahepatic cholangiocarcinoma. (23355033)
2013
9
Penile metastasis from primary cholangiocarcinoma: the first case report. (24124668)
2013
10
Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma. (24062361)
2013
11
Distal fibula metastasis of cholangiocarcinoma. (23578566)
2013
12
An extended fluorescence in situ hybridization approach for the cytogenetic study of cholangiocarcinoma on endoscopic retrograde cholangiopancreatography brushing cytology preparations. (23845469)
2013
13
Transforming growth factor I^ neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide-treated rats. (23349909)
2013
14
CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. (23809433)
2013
15
Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma. (23167387)
2012
16
Predictive factors of recurrence for patients with intrahepatic cholangiocarcinoma after hepatectomy. (22369746)
2012
17
Radiological staging in patients with hilar cholangiocarcinoma: a systematic review and meta-analysis. (22919007)
2012
18
The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma. (22406361)
2012
19
A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model. (22248567)
2012
20
miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma. (21953056)
2012
21
Double primary cancers: intrahepatic cholangiocarcinoma with myocardial metastases and lung squamous cell carcinoma. (22975543)
2012
22
Surgical Approach for Long-term Survival of Patients With Intrahepatic Cholangiocarcinoma: A Multi-institutional Analysis of 434 Patients. (22910846)
2012
23
A novel serum carbohydrate marker on mucin 5AC: values for diagnostic and prognostic indicators for cholangiocarcinoma. (21287531)
2011
24
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. (21253578)
2011
25
Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma. (20545696)
2010
26
Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma. (20872971)
2010
27
Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. (20493868)
2010
28
Cytoplasmic overexpression with membrane accentuation of stratifin in intrahepatic mass-forming cholangiocarcinoma after hepatectomy: correlation with clinicopathologic features and patient survival. (20976731)
2010
29
Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis. (18835624)
2009
30
Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature. (19282767)
2009
31
Overlapping signature genes between hepatocellular carcinoma and intrahepatic cholangiocarcinoma. (19826380)
2009
32
Intrahepatic cholangiocarcinoma. (19247046)
2009
33
Endobiliary metastasis from rectal cancer mimicking intrahepatic cholangiocarcinoma: a case report and review of literature. (19921471)
2009
34
Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? (18329969)
2008
35
Do PPARgamma Ligands Suppress the Growth of Cholangiocarcinoma or the Cholangiohepatitis Induced by the Tumor? (18615198)
2008
36
Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts. (18329694)
2008
37
Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells. (17654480)
2008
38
Expression of mucin glycoproteins and cytokeratins in intrahepatic cholangiocarcinoma]. (19094709)
2008
39
A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene. (17051350)
2007
40
Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case. (16715430)
2006
41
The associated expression of Maspin and Bax proteins as a potential prognostic factor in intrahepatic cholangiocarcinoma. (17067385)
2006
42
Response to cetuximab and gemcitabine-oxaliplatin in an advanced case of intrahepatic cholangiocarcinoma. (16817335)
2006
43
Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions. (16116640)
2005
44
gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. (16357152)
2005
45
Proteomic analysis of cholangiocarcinoma cell line. (15048994)
2004
46
Combined hepatocellular and cholangiocarcinoma: a clinicopathologic study of 26 resected cases. (12913082)
2003
47
Immunohistochemically demonstrated lymph node micrometastasis and prognosis in patients with otherwise node-negative hilar cholangiocarcinoma. (12560778)
2003
48
Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide. (12587840)
2002
49
Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. (10646872)
2000
50
An immunohistochemical study of hepatic atypical adenomatous hyperplasia, hepatocellular carcinoma, and cholangiocarcinoma with alpha-fetoprotein, carcinoembryonic antigen, CA19-9, epithelial membrane antigen, and cytokeratins 18 and 19. (10365850)
1999

Genetic Variations for Cholangiocarcinoma

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Expression for genes affiliated with Cholangiocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangiocarcinoma

Search GEO for disease gene expression data for Cholangiocarcinoma.

Pathways for genes affiliated with Cholangiocarcinoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Cholangiocarcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Cholangiocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1paraffin4413.6TIMP3, CEACAM3, HGF, MET, VEGFC, MAGEA3
2tyrosine4413.6KRT20, KRT7, KRT19, CFLAR, MCL1, CDKN1B
3progesterone44 59 28 11 2417.3TIMP3, MET, AFP, VEGFC, CEACAM3, LGALS3
4retinoic acid44 2414.3TIMP3, HGF, MET, AFP, VEGFC, MUC2
5calcium44 49 11 2416.3MUC2, MUC5AC, MUC1, MUC4, CDX2, CFLAR
6oligonucleotide4413.2AFP, MET, OGG1, TIMP3, MCL1, CDKN1B
7oxygen44 2414.2TIMP3, HGF, OGG1, MET, AFP, VEGFC
8vegf4413.2KRT20, KRT7, LGALS3, CEACAM3, KRT19, CFLAR
9testosterone44 59 11 2415.8KRT7, AFP, CFLAR, MUC1, HGF, VEGFC
10thymidine44 2413.7CEACAM3, VEGFC, AFP, MET, HGF, OGG1
11glucose4412.7KRT19, MET, TIMP3, CEACAM3, KRT7, MUC2
12phosphatidylinositol4412.5CFLAR, MCL1, CDKN1B, MUC4, MUC5AC, VEGFC
135fluorouracil4412.3MUC5AC, CFLAR, MCL1, CDKN1B, MUC1, CEACAM3
14matrigel4412.3KRT7, KRT19, MUC4, MUC1, VEGFC, MET
15lipid4412.3MCL1, MUC1, VEGFC, CFLAR, AFP, KRT7
16pd 98,0594412.3MCL1, CDKN1B, MUC5AC, MUC2, VEGFC, MET
17glycogen44 2413.3MET, AFP, MUC1, HGF, MCL1, KRT19
18cisplatin44 49 59 1115.3MCL1, CDKN1B, LGALS3, KRT19, CFLAR, MUC1
19dexamethasone44 49 28 1115.3MCL1, CDKN1B, MUC4, MUC5AC, MUC2, AFP
20nitric oxide44 11 2414.2LGALS3, CEACAM3, CFLAR, MUC1, MUC5AC, MET
21threonine4412.2LGALS3, CFLAR, CDKN1B, MUC1, MUC5AC, MCL1
22hematoxylin4412.2MUC5AC, MUC2, KRT20, LGALS3, CEACAM3, MUC1
23methotrexate44 49 1114.2KRT7, CDKN1B, MUC1, MUC5AC, AFP, MUC2
24ly2940024412.1MUC2, CFLAR, VEGFC, MET, HGF, CDKN1B
25actinomycin d4412.1HGF, CFLAR, MCL1, CDKN1B, MET, AFP
26cysteine4412.1LGALS3, MET, MUC2, MUC5AC, CFLAR, MUC1
27cholesterol44 28 11 2415.0AFP, MET, MUC2, MUC5AC, MUC4, CDKN1B
28dmso4412.0HGF, MUC1, CDKN1B, MUC5AC, MUC2, AFP
29steroid4412.0CEACAM3, TIMP3, MET, MUC4, CDX2, KRT19
30ribonucleic acid4411.9KRT19, VEGFC, MET, MUC5AC, TIMP3, KRT20
3112-o-tetradecanoylphorbol 13-acetate4411.9HGF, TIMP3, MCL1, CDKN1B, MUC1, MUC2
32wortmannin4411.9TIMP3, LGALS3, CFLAR, CDKN1B, MET, MCL1
33doxorubicin44 49 1113.9CDKN1B, AFP, CFLAR, KRT20, CEACAM3, HGF
34adriamycin4411.9CEACAM3, CFLAR, AFP, MUC1, HGF, OGG1
35b 7234411.9KRT20, KRT19, AFP, CEACAM3, KRT7, MUC1
36serine4411.8MUC5AC, MUC2, AFP, CDKN1B, CFLAR, KRT19
37formaldehyde44 2412.7KRT19, CDKN1B, MUC1, KRT7, KRT20, LGALS3
38agar4411.7LGALS3, CDKN1B, MET, HGF, AFP, MUC1
39etoposide44 49 59 1114.6CDKN1B, MCL1, LGALS3, HGF, AFP, CFLAR
40estradiol44 11 2413.5CFLAR, VEGFC, AFP, TIMP3
41polysaccharide4411.4AFP, LGALS3, KRT7, MUC1, MUC5AC, HGF
42mucicarmine4411.4MUC1, KRT7, KRT20, CEACAM3
43paclitaxel44 49 1113.3HGF, CDKN1B, MCL1, CFLAR, KRT19, AFP
44carbohydrates4411.3KRT19, MUC5AC, MUC2
45sialic acid4411.2CEACAM3, KRT7
46butyrate4411.2MCL1, CDX2
47trastuzumab44 49 1113.1CDKN1B, MUC4, MUC1, VEGFC
48galactose4411.1CEACAM3, LGALS3, MUC2
49heparin44 28 11 2414.0CDKN1B, AFP, TIMP3
505-aza-2deoxycytidine4411.0CDX2, KRT7, CFLAR, MUC2, TIMP3

GO Terms for genes affiliated with Cholangiocarcinoma

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16Gene Ontology
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Cellular components related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588211.0KRT20, KRT7, KRT19
2Golgi lumenGO:00579610.8MUC4, MUC1, MUC5AC, MUC2

Biological processes related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:01626611.2MUC4, MUC1, MUC5AC, MUC2
2post-translational protein modificationGO:04368711.1MUC4, MUC1, MUC5AC, MUC2
3negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.8MET, HGF
4myoblast proliferationGO:05145010.7HGF, MET
5regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.5MET, HGF

Molecular functions related to Cholangiocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.9LGALS3, HGF, OGG1, MET, VEGFC, MAGEA3

Products for genes affiliated with Cholangiocarcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Cholangiocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet