MCID: CHL040
MIFTS: 30

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 46 C41617
UMLS 69 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to hepatitis and pancreatic mucinous cystadenoma, and has symptoms including malaise and abdominal pain. An important gene associated with Cholangiolocellular Carcinoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 hepatitis 10.3
2 pancreatic mucinous cystadenoma 10.2 EZH2 MUC1
3 hepatocellular carcinoma 10.2
4 gastrointestinal carcinoma 10.1 ABCB1 MUC1
5 cholangiocarcinoma 10.1
6 bile duct carcinoma 10.0 ABCC3 MUC1
7 small intestinal adenocarcinoma 10.0 MUC1 PROM1
8 malignant peritoneal mesothelioma 9.9 CDKN2A MUC1
9 mucinous bronchioloalveolar adenocarcinoma 9.9 CDKN2A MUC1
10 endometrial mucinous adenocarcinoma 9.9 CDKN2A MUC1
11 sarcomatoid mesothelioma 9.9 CDKN2A MUC1
12 pleomorphic liposarcoma 9.9 CDKN2A MUC1
13 ischemic fasciitis 9.9 CDKN2A MUC1
14 well-differentiated liposarcoma 9.9 CDKN2A MUC1
15 meningeal melanocytoma 9.9 CDKN2A MUC1
16 peritoneal mesothelioma 9.9 CDKN2A MUC1
17 biliary tract neoplasm 9.9 CDKN2A MUC1
18 hepatitis c virus 9.8
19 alcoholic liver cirrhosis 9.8
20 liver cirrhosis 9.8
21 sclerosing cholangitis 9.8
22 hepatitis c 9.8
23 viral hepatitis 9.8
24 intrahepatic cholangiocarcinoma 9.8
25 adenoma 9.8
26 cholangitis 9.8
27 acute lymphoblastic leukemia, childhood 9.8 ABCB1 CDKN2A
28 mucinous adenocarcinoma 9.8 CDKN2A MUC1
29 histiocytic sarcoma 9.8 CDKN2A MUC1
30 pancreatic ductal carcinoma 9.8 CDKN2A MUC1
31 chordoma 9.8 CDKN2A MUC1
32 gastric adenosquamous carcinoma 9.8 CDKN2A PROM1
33 neurofibroma 9.8 CDKN2A MUC1
34 cholecystitis 9.8 CDKN2A MUC1
35 leukemia, acute lymphoblastic 9.8 ABCB1 CDKN2A
36 female reproductive organ cancer 9.8 CDKN2A MUC1
37 malignant pleural mesothelioma 9.8 CDKN2A MUC1
38 mesothelioma, malignant 9.7 CDKN2A MUC1
39 acute lymphocytic leukemia 9.7 ABCB1 CDKN2A
40 malignant peripheral nerve sheath tumor 9.6 CDKN2A MUC1
41 gastrointestinal system cancer 9.6 CDKN2A PROM1
42 leukemia, acute myeloid 9.6 ABCB1 CDKN2A EZH2
43 gallbladder cancer 9.6 CDKN2A MUC1
44 plasmablastic lymphoma 9.6 ABCB1 CDKN2A MUC1
45 myeloma, multiple 9.6 ABCB1 CDKN2A
46 mantle cell lymphoma 9.4 CDKN2A EZH2
47 pancreas adenocarcinoma 9.4 CDKN2A MUC1 PROM1
48 pancreatic ductal adenocarcinoma 9.4 CDKN2A MUC1 PROM1
49 cell type cancer 9.4 CDKN2A MUC1 PROM1
50 bladder cancer 9.4 CDKN2A EZH2 MUC1

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


malaise, abdominal pain

GenomeRNAi Phenotypes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 ABCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.23 ABCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 ABCB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.23 ABCB1 ABCC3 EZH2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 EZH2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 ABCB1

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ABCB1 ABCC3 CDKN2A EZH2 PROM1
2 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

38
Liver

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show all 41)
# Title Authors Year
1
Skull metastasis from cholangiolocellular carcinoma. ( 28462886 )
2017
2
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. ( 28458143 )
2017
3
Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor. ( 29198012 )
2017
4
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. ( 28943584 )
2017
5
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. ( 28652894 )
2017
6
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. ( 28126467 )
2017
7
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. ( 28916905 )
2017
8
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. ( 28439650 )
2017
9
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. ( 27363839 )
2016
10
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. ( 27748735 )
2016
11
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. ( 28105354 )
2016
12
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. ( 27747442 )
2016
13
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 27878570 )
2016
14
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. ( 27345000 )
2016
15
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
16
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. ( 27344994 )
2016
17
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. ( 26157757 )
2015
18
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. ( 26179521 )
2015
19
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. ( 26414834 )
2015
20
Integrins I+vI^6, I+6I^4 and I+3I^1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. ( 24552196 )
2014
21
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. ( 24633664 )
2014
22
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
23
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. ( 25253466 )
2014
24
High expression of cancer stem cell markers in cholangiolocellular carcinoma. ( 23192764 )
2013
25
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. ( 24693685 )
2013
26
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. ( 22179577 )
2012
27
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. ( 23397537 )
2012
28
A case of a large cholangiolocellular carcinoma. ( 26189636 )
2011
29
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. ( 21344355 )
2011
30
Imaging of cholangiolocellular carcinoma of the liver. ( 19781883 )
2010
31
Cholangiolocellular carcinoma of the liver: imaging findings. ( 19820492 )
2009
32
A case of cholangiolocellular carcinoma asynchronously developing 3 years after the resection of hepatocellular carcinoma. ( 26192297 )
2009
33
A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. ( 19208040 )
2009
34
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. ( 18393293 )
2008
35
Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver:a case report. ( 18319561 )
2008
36
Synchronously resected double primary hepatic cancers - hepatocellular carcinoma and cholangiolocellular carcinoma. ( 17139434 )
2006
37
Clinicopathologic study on cholangiolocellular carcinoma. ( 11182037 )
2001
38
Cholangiolocellular carcinoma of the liver: CT and MR findings. ( 11045707 )
2000
39
Hepatic recurrence of cholangiolocellular carcinoma: report of a case. ( 8884337 )
1996
40
CHOLANGIOLOCELLULAR CARCINOMA OF THE LIVER. ( 14207070 )
1964
41
Cholangiolocellular carcinoma of the liver. ( 13663020 )
1959

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Cellular components related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ABCB1 MUC1 PROM1

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug transmembrane transport GO:0006855 8.96 ABCB1 ABCC3
2 xenobiotic transport GO:0042908 8.62 ABCB1 ABCC3

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.16 ABCB1 ABCC3
2 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.96 ABCB1 ABCC3
3 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.62 ABCB1 ABCC3

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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