MCID: CHL040
MIFTS: 29

Cholangiolocellular Carcinoma malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

Aliases & Descriptions for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 47 C41617
UMLS 69 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to hepatitis and nodular basal cell carcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit), and among its related pathways/superpathways are Glucose / Energy Metabolism and MicroRNAs in cancer. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Related Diseases for Cholangiolocellular Carcinoma

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

GenomeRNAi Phenotypes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 ABCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.23 ABCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 ABCB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.23 ABCB1 ABCC3 EZH2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 EZH2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 ABCB1

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 ABCB1 ABCC3 CDKN2A EZH2 PROM1
2 nervous system MP:0003631 9.35 ABCB1 ABCC1 CDKN2A EZH2 PROM1
3 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

39
Liver

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show all 32)
id Title Authors Year
1
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. ( 27363839 )
2016
2
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. ( 27344994 )
2016
3
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. ( 27747442 )
2016
4
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. ( 27345000 )
2016
5
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
6
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. ( 27748735 )
2016
7
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 27878570 )
2016
8
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. ( 26157757 )
2015
9
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. ( 26414834 )
2015
10
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. ( 26179521 )
2015
11
Integrins I+vI^6, I+6I^4 and I+3I^1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. ( 24552196 )
2014
12
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
13
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. ( 24633664 )
2014
14
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. ( 25253466 )
2014
15
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. ( 24693685 )
2013
16
High expression of cancer stem cell markers in cholangiolocellular carcinoma. ( 23192764 )
2013
17
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. ( 23397537 )
2012
18
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. ( 22179577 )
2012
19
A case of a large cholangiolocellular carcinoma. ( 26189636 )
2011
20
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. ( 21344355 )
2011
21
Imaging of cholangiolocellular carcinoma of the liver. ( 19781883 )
2010
22
A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. ( 19208040 )
2009
23
A case of cholangiolocellular carcinoma asynchronously developing 3 years after the resection of hepatocellular carcinoma. ( 26192297 )
2009
24
Cholangiolocellular carcinoma of the liver: imaging findings. ( 19820492 )
2009
25
Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver:a case report. ( 18319561 )
2008
26
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. ( 18393293 )
2008
27
Synchronously resected double primary hepatic cancers - hepatocellular carcinoma and cholangiolocellular carcinoma. ( 17139434 )
2006
28
Clinicopathologic study on cholangiolocellular carcinoma. ( 11182037 )
2001
29
Cholangiolocellular carcinoma of the liver: CT and MR findings. ( 11045707 )
2000
30
Hepatic recurrence of cholangiolocellular carcinoma: report of a case. ( 8884337 )
1996
31
CHOLANGIOLOCELLULAR CARCINOMA OF THE LIVER. ( 14207070 )
1964
32
Cholangiolocellular carcinoma of the liver. ( 13663020 )
1959

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

Pathways related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1 12.18 ABCB1 ABCC1 ABCC3
2 12.1 ABCB1 ABCC1 CDKN2A EZH2
3
Show member pathways
11.81 ABCB1 ABCC1 ABCC3
4 11.48 EZH2 PROM1
5 11.42 ABCB1 ABCC3
6
Show member pathways
11.3 ABCB1 ABCC1
7
Show member pathways
11.15 ABCB1 ABCC1
8 11.07 ABCB1 ABCC3
9 11.02 ABCB1 ABCC3
10 10.99 ABCC1 ABCC3
11
Show member pathways
10.86 ABCB1 ABCC3
12 10.82 ABCB1 ABCC1
13
Show member pathways
10.73 ABCB1 ABCC1 ABCC3
14 10.66 ABCB1 ABCC3
15 10.59 ABCB1 ABCC1 ABCC3
16 10.48 ABCB1 ABCC1
17 10.31 ABCB1 ABCC1 ABCC3
18 9.8 ABCB1 ABCC1 ABCC3

GO Terms for Cholangiolocellular Carcinoma

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.43 ABCB1 ABCC1 ABCC3
2 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.16 ABCC1 ABCC3
3 drug transmembrane transport GO:0006855 9.13 ABCB1 ABCC1 ABCC3
4 xenobiotic transport GO:0042908 8.8 ABCB1 ABCC1 ABCC3

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCB1 ABCC1 ABCC3
2 transporter activity GO:0005215 9.43 ABCB1 ABCC1 ABCC3
3 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.16 ABCC1 ABCC3
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB1 ABCC1 ABCC3
5 xenobiotic-transporting ATPase activity GO:0008559 8.8 ABCB1 ABCC1 ABCC3

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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