MCID: CHL040
MIFTS: 28

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 47 C41617
UMLS 69 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to uterine corpus apoplectic leiomyoma and striated muscle rhabdoid tumor, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 uterine corpus apoplectic leiomyoma 10.3 EZH2 MUC1
2 striated muscle rhabdoid tumor 10.2 ABCB1 MUC1
3 hepatitis 10.2
4 urethra adenocarcinoma 10.1 ABCC3 MUC1
5 sohval soffer syndrome 10.1 MUC1 PROM1
6 hepatocellular carcinoma 10.1
7 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 9.9 CDKN2A MUC1
8 chronic neutrophilic leukemia 9.9 CDKN2A MUC1
9 bladder colloid adenocarcinoma 9.9 CDKN2A MUC1
10 persian gulf syndrome 9.9 CDKN2A MUC1
11 diffuse meningeal melanocytosis 9.9 CDKN2A MUC1
12 spindle cell liposarcoma 9.9 CDKN2A MUC1
13 neurofibroma of the esophagus 9.9 CDKN2A MUC1
14 spastic ataxia 3 9.9 CDKN2A MUC1
15 phobic disorder 9.9 CDKN2A MUC1
16 advanced sleep phase syndrome 9.9 CDKN2A MUC1
17 tumor of exocrine pancreas 9.9 CDKN2A MUC1
18 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 9.9 CDKN2A MUC1
19 acute monocytic leukemia 9.9 ABCB1 CDKN2A
20 cecum adenocarcinoma 9.9 CDKN2A MUC1
21 choriocarcinoma 9.8 CDKN2A MUC1
22 kidney hypertrophy 9.8 CDKN2A MUC1
23 malignant giant cell tumor of soft parts 9.8 CDKN2A PROM1
24 fallopian tube leiomyosarcoma 9.8 CDKN2A MUC1
25 pancreatic somatostatinoma 9.8 CDKN2A MUC1
26 estrogen-receptor negative breast cancer 9.8 CDKN2A MUC1
27 trachea squamous cell carcinoma 9.8 CDKN2A MUC1
28 hepatitis c virus 9.8
29 alcoholic liver cirrhosis 9.8
30 liver cirrhosis 9.8
31 sclerosing cholangitis 9.8
32 hepatitis c 9.8
33 viral hepatitis 9.8
34 intrahepatic cholangiocarcinoma 9.8
35 adenoma 9.8
36 cholangitis 9.8
37 mesothelioma, somatic 9.7 CDKN2A MUC1
38 periventricular nodular heterotopia 6 9.7 CDKN2A MUC1
39 large cell carcinoma with rhabdoid phenotype 9.7 CDKN2A MUC1
40 acute myocardial infarction 9.7 ABCB1 CDKN2A
41 bladder urachal squamous cell carcinoma 9.7 CDKN2A MUC1
42 nail disorder, nonsyndromic congenital, 1 9.6 ABCB1 CDKN2A
43 gallbladder cancer 9.6 CDKN2A PROM1
44 small cell cancer of the lung, somatic 9.6 ABCB1 CDKN2A
45 megakaryocytic leukemia 9.5 CDKN2A EZH2
46 cranioectodermal dysplasia 1 9.5 ABCB1 CDKN2A EZH2
47 acute porphyria 9.5 CDKN2A MUC1
48 plummer vinson syndrome 9.5 ABCB1 CDKN2A MUC1
49 gastric fundus cancer 9.4 ABCB1 CDKN2A MUC1
50 paroxysmal nocturnal hemoglobinuria 9.3 CDKN2A MUC1 PROM1

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

GenomeRNAi Phenotypes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 ABCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.23 ABCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 ABCB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.23 ABCB1 ABCC3 EZH2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 EZH2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 ABCB1

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ABCB1 ABCC3 CDKN2A EZH2 PROM1
2 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

39
Liver

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show all 40)
id Title Authors Year
1
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. ( 28458143 )
2017
2
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. ( 28652894 )
2017
3
Skull metastasis from cholangiolocellular carcinoma. ( 28462886 )
2017
4
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. ( 28439650 )
2017
5
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. ( 28916905 )
2017
6
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. ( 28126467 )
2017
7
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. ( 28943584 )
2017
8
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 27878570 )
2016
9
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. ( 27344994 )
2016
10
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. ( 27363839 )
2016
11
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. ( 27345000 )
2016
12
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. ( 27748735 )
2016
13
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
14
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. ( 28105354 )
2016
15
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. ( 27747442 )
2016
16
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. ( 26179521 )
2015
17
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. ( 26414834 )
2015
18
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. ( 26157757 )
2015
19
Integrins I+vI^6, I+6I^4 and I+3I^1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. ( 24552196 )
2014
20
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. ( 24633664 )
2014
21
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
22
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. ( 25253466 )
2014
23
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. ( 24693685 )
2013
24
High expression of cancer stem cell markers in cholangiolocellular carcinoma. ( 23192764 )
2013
25
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. ( 23397537 )
2012
26
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. ( 22179577 )
2012
27
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. ( 21344355 )
2011
28
A case of a large cholangiolocellular carcinoma. ( 26189636 )
2011
29
Imaging of cholangiolocellular carcinoma of the liver. ( 19781883 )
2010
30
Cholangiolocellular carcinoma of the liver: imaging findings. ( 19820492 )
2009
31
A case of cholangiolocellular carcinoma asynchronously developing 3 years after the resection of hepatocellular carcinoma. ( 26192297 )
2009
32
A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. ( 19208040 )
2009
33
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. ( 18393293 )
2008
34
Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver:a case report. ( 18319561 )
2008
35
Synchronously resected double primary hepatic cancers - hepatocellular carcinoma and cholangiolocellular carcinoma. ( 17139434 )
2006
36
Clinicopathologic study on cholangiolocellular carcinoma. ( 11182037 )
2001
37
Cholangiolocellular carcinoma of the liver: CT and MR findings. ( 11045707 )
2000
38
Hepatic recurrence of cholangiolocellular carcinoma: report of a case. ( 8884337 )
1996
39
CHOLANGIOLOCELLULAR CARCINOMA OF THE LIVER. ( 14207070 )
1964
40
Cholangiolocellular carcinoma of the liver. ( 13663020 )
1959

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Cellular components related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ABCB1 MUC1 PROM1

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 drug transmembrane transport GO:0006855 8.96 ABCB1 ABCC3
2 xenobiotic transport GO:0042908 8.62 ABCB1 ABCC3

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.96 ABCB1 ABCC3
2 xenobiotic-transporting ATPase activity GO:0008559 8.62 ABCB1 ABCC3

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....