MCID: CHL066
MIFTS: 55

Cholangitis malady

Gastrointestinal diseases category
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Summaries for Cholangitis

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Wikipedia:65 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards based summary: Cholangitis is related to primary biliary cirrhosis and ulcerative colitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Selected targets of HNF1 and Selected targets of C EBPalpha. The compounds lactulose and glycyrrhizin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Disease Ontology:8 A bile duct disease that is an inflammation of the bile duct.

Aliases & Classifications for Cholangitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Cholangitis, Aliases & Descriptions:

Name: Cholangitis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:9446
ICD9CM27 576.1
MeSH34 D002761
NCIt39 C26718
ICD1025 K83.0

Related Diseases for Cholangitis

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Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1primary biliary cirrhosis31.5CFTR, ABCB4
2ulcerative colitis31.3BPI, LTF, CTSG
3hepatitis31.3GPT, SLC17A5, LTF
4pancreatitis31.1SLC17A5, LTF, ABCB4, CFTR
5choledocholithiasis31.1GPT, SLC17A5
6autoimmune hepatitis31.1GPT, SLC17A5
7obstructive jaundice30.8GPT, SLC17A5
8inflammatory bowel disease30.8LTF, BPI, CTSG, NR1I2
9cholelithiasis30.7GPT, ABCB4
10acute pancreatitis30.6GPT, SLC17A5, CFTR
11portal hypertension30.5GPT, SLC17A5
12polyarteritis nodosa30.4LTF
13liver cirrhosis30.2HP, SLC17A5, GPT
14pneumonia30.2BPI, CFTR, CTSG
15primary sclerosing cholangitis30.2LTF, CTSG, BPI, GPT, CFTR, HLA-C
16hepatitis b30.1GPT, SLC17A5
17sepsis30.1BPI, NR1I2, CTSG, LTF
18bronchiectasis30.0CFTR, BPI, CTSG
19thrombocytopenia30.0GPT, HP, SLC17A5
20cholestasis29.8NR1I2, SLC17A5, ABCC2, GPT, ABCB4
21cystic fibrosis29.7LTF, BPI, CTSG, HP, ABCC2, CFTR
22arthritis29.7LTF, CTSG, HP, HLA-C
23intrahepatic cholestasis29.5SLC17A5, ABCC2, ABCB4, NR1I2
24fatty liver disease29.3HP, NR1I2, ABCC2, SLC17A5, GPT
25hepatitis c29.1ABCC2, HP, HLA-C, GPT, SLC17A5
26sclerosing cholangitis11.3
27acute cholangitis11.0
28colitis10.8
29suppurative cholangitis10.8
30cholangiocarcinoma10.7
31ascending cholangitis10.7
32autoimmune pancreatitis10.7
33cholecystitis10.6
34chronic cholangitis10.5
35crohn's disease10.4
36biliary atresia10.4
37ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.4
38liver disease10.3
39duodenitis10.3
40retroperitoneal fibrosis10.3
41mastitis10.3LTF, HP
42bacteremia10.3
43pyridoxine deficiency10.3SLC17A5, GPT
44acute liver failure10.3GPT, SLC17A5
45colorectal cancer10.3
46bile duct carcinoma10.3
47scrub typhus10.3GPT, SLC17A5
48keratoconjunctivitis sicca10.3CFTR, LTF
49hemochromatosis10.3CFTR, HP
50hepatic encephalopathy10.3SLC17A5, GPT

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Symptoms for Cholangitis

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Drugs & Therapeutics for Cholangitis

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Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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MalaCards organs/tissues related to Cholangitis:

32
Liver, Colon, Small intestine, T cells, Thyroid, Testes, Neutrophil, Pancreas, Bone, B cells, Lymph node, Kidney, Lung, Myeloid, Bone marrow, Heart, Salivary gland

Animal Models for Cholangitis or affiliated genes

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MGI Mouse Phenotypes related to Cholangitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.3LTF, ABCB4, ABCC2, CFTR, HP, NR1I2
2MP:00053767.2ABCC2, CFTR, CLDN1, HP, NR1I2, SLC17A5

Publications for Cholangitis

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Articles related to Cholangitis:

(show top 50)    (show all 1279)
idTitleAuthorsYear
1
Dedicator of cytokinesis 8 deficiency: A predisposition to sclerosing cholangitis. (25220305)
2014
2
Reply to intrapancreatic biliary stricture in autoimmune pancreatitis should not be included in IgG4-related sclerosing cholangitis. (25207661)
2014
3
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
4
Primary Sclerosing Cholangitis: Current and Future Management Strategies. (23682242)
2013
5
Effects of immunosuppression and liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. (23376317)
2013
6
Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis. (23528654)
2013
7
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
8
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
9
Extended Spectrum-I^-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis. (22866257)
2012
10
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
11
Primary sclerosing cholangitis and distribution of inflammatory bowel disease. (22835578)
2012
12
Taenia saginata a rare cause of acute cholangitis: a case report. (23340150)
2012
13
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
14
Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans. (21934101)
2012
15
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
16
Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity. (22098817)
2012
17
Factors that reduce health-related quality of life in patients with primary sclerosing cholangitis. (22343690)
2012
18
Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment. (23075867)
2012
19
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. (21134112)
2011
20
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
21
Electrostatic modifications of the human leukocyte antigen DR P9 peptide-binding pocket in primary sclerosing cholangitis: back to the future with human leukocyte antigen DRI^. (21538433)
2011
22
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
23
Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. (21893134)
2011
24
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
25
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
26
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
27
Acute cholangitis due to pancreatic metastasis from squamous cell lung carcinoma: a case report and review of literature. (20062690)
2009
28
Long-term treatment of primary sclerosing cholangitis in children with oral vancomycin: an immunomodulating antibiotic. (18607270)
2008
29
Current concept about postoperative cholangitis in biliary atresia. (18402246)
2008
30
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. (17335678)
2007
31
Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines. (17252295)
2007
32
Efficacy and safety of early laparoscopic common bile duct exploration as primary procedure in acute cholangitis caused by common bile duct stones. (17907977)
2007
33
Primary sclerosing cholangitis. (17440311)
2007
34
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (16638702)
2006
35
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
36
Acute cholangitis caused by intra-biliary rupture of pancreatic hydatid cyst. (15453052)
2004
37
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis. (15215889)
2004
38
Acute cholangitis. (12957832)
2003
39
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
40
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
41
Primary sclerosing cholangitis in a child. (10365542)
1999
42
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
43
The role of endoscopic papillotomy in ascending cholangitis. (2053744)
1991
44
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
45
Ultrasonography of acute obstructive suppurative cholangitis: serial observation by ultrasound. (3106424)
1987
46
Trimethoprim-sulfamethoxazole treatment of cholangitis complicating congenital hepatic fibrosis. (3523453)
1986
47
Acute suppurative cholangitis secondary to malignant obstruction. (7284909)
1981
48
Acute obstructive suppurative cholangitis. (5782750)
1969
49
Acute suppurative cholangitis with recovery after the use of penicillin and streptomycin. (18862498)
1948
50
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)
1931

Variations for Cholangitis

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Expression for genes affiliated with Cholangitis

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Expression patterns in normal tissues for genes affiliated with Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

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Compounds for genes affiliated with Cholangitis

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Compounds related to Cholangitis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1lactulose449.5LTF, SLC17A5, GPT
2glycyrrhizin44 2810.4GPT, LTF, SLC17A5
3adefovir449.4ABCC2, GPT, SLC17A5
4tenofovir44 50 1111.4SLC17A5, ABCC2, GPT
5malondialdehyde449.4GPT, HP, CTSG, SLC17A5
6ribavirin44 50 1111.2LTF, GPT, HP, SLC17A5
7vitamin-e449.2SLC17A5, HP, NR1I2, GPT
8vitamin b12449.2SLC17A5, LTF, HP, GPT
9neopterin449.2LTF, HP, SLC17A5, GPT
10carbohydrates449.2CFTR, HP, LTF, CTSG
11chenodeoxycholic acid44 28 24 1112.2GPT, NR1I2, ABCC2, ABCB4
12ezetimibe44 1110.2ABCC2, GPT, SLC17A5
13glycocholate449.2SLC17A5, ABCB4, ABCC2, GPT
14thyroxine44 2410.1SLC17A5, NR1I2, GPT, HP
15nevirapine44 50 1111.1GPT, SLC17A5, HLA-C
16lamivudine44 50 1111.1GPT, ABCC2, SLC17A5
17clotrimazole28 44 24 1112.1ABCC2, NR1I2, CFTR
18hyaluronic acid44 2410.0SLC17A5, GPT, HP, LTF
19acetaminophen44 2 50 24 1112.9ABCC2, GPT, NR1I2, SLC17A5
20phospholipid448.9HP, ABCB4, SLC17A5, BPI, CTSG
21phenobarbital44 28 50 1111.9NR1I2, SLC17A5, GPT, ABCC2
22verapamil44 28 50 24 1112.8SLC17A5, ABCB4, ABCC2, CFTR, GPT
23endotoxin448.8CTSG, LTF, BPI, SLC17A5, HP
24fibrinogen448.8CTSG, SLC17A5, HP, GPT, LTF
25lactate448.8BPI, SLC17A5, GPT, CTSG, HP
26vitamin a44 24 1110.8GPT, SLC17A5, LTF, NR1I2, HP
27epinephrine44 24 1110.7CFTR, HP, CTSG, ABCC2, SLC17A5
28rosuvastatin44 50 28 1111.7SLC17A5, GPT, ABCC2
29ursodeoxycholic acid44 24 1110.7SLC17A5, NR1I2, ABCB4, GPT, ABCC2
30tacrolimus44 50 1110.7GPT, NR1I2, SLC17A5, ABCC2, ABCB4
31methotrexate50 44 1110.7SLC17A5, GPT, NR1I2, ABCC2, ABCB4
32actinomycin d448.6HP, LTF, ABCC2, CFTR, BPI
33cholesterol44 28 24 1111.5HP, NR1I2, ABCB4, BPI, SLC17A5, GPT
34n acetylcysteine448.5LTF, SLC17A5, GPT, CFTR, ABCC2
35sodium44 249.4CFTR, ABCC2, HP, GPT, SLC17A5, CTSG
36urea44 24 1110.4GPT, BPI, HP, CTSG, SLC17A5, ABCC2
37dexamethasone44 50 28 1111.3NR1I2, CFTR, ABCB4, ABCC2, HP, LTF
38heparin44 28 24 1111.3SLC17A5, CTSG, HP, LTF, BPI
39aspartate448.2GPT, LTF, SLC17A5, CTSG, HP, CFTR
40rifampicin44 28 6110.2SLC17A5, GPT, HP, NR1I2, LTF, ABCC2
41glutamate448.1ABCC2, GPT, HP, SLC17A5, LTF, CFTR
42glucose448.1HP, SLC17A5, NR1I2, CTSG, GPT, BPI
43nitric oxide44 24 1110.1HP, SLC17A5, ABCC2, BPI, NR1I2, CTSG
44estrogen448.1LTF, NR1I2, HP, CFTR, ABCB4, ABCC2
45atp44 289.0ABCC2, ABCB4, CFTR, NR1I2, CTSG, SLC17A5
46creatinine447.9GPT, CTSG, ABCC2, BPI, HP, LTF
47retinoic acid44 248.9LTF, CFTR, ABCC2, BPI, NR1I2, CTSG
48alanine447.8CFTR, LTF, SLC17A5, CTSG, BPI, GPT
49lipid447.6CTSG, ABCC2, SLC17A5, NR1I2, BPI, GPT
50cyclosporin a44 28 619.6GPT, HP, NR1I2, SLC17A5, LTF, CFTR

GO Terms for genes affiliated with Cholangitis

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Cellular components related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:0465819.6ABCC2, ABCB4
2apical plasma membraneGO:0163248.8ABCB4, ABCC2, CFTR, CLDN1
3integral component of plasma membraneGO:0058877.5SLC17A5, BPI, CLDN1, HLA-C, ABCC2, ABCB4
4extracellular vesicular exosomeGO:0700627.4HLA-C, GPT, BPI, HP, CTSG, LTF

Biological processes related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transportGO:0068108.9ABCB4, ABCC2, CFTR
2immune responseGO:0069558.9CTSG, BPI, HLA-C
3transmembrane transportGO:0550858.6SLC17A5, CFTR, ABCC2, ABCB4

Molecular functions related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:0426269.6ABCC2, ABCB4

Products for genes affiliated with Cholangitis

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Sources for Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet