MCID: CHL066
MIFTS: 48

Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholangitis

MalaCards integrated aliases for Cholangitis:

Name: Cholangitis 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9446
ICD10 33 K83.0
ICD9CM 35 576.1
MeSH 42 D002761
NCIt 47 C26718
UMLS 69 C0008311

Summaries for Cholangitis

Disease Ontology : 12 A bile duct disease that is an inflammation of the bile duct.

MalaCards based summary : Cholangitis is related to acute cholangitis and gastric ulcer. An important gene associated with Cholangitis is CLDN1 (Claudin 1), and among its related pathways/superpathways are Rheumatoid arthritis and IgA-Producing B Cells in the Intestine. The drugs Amoxicillin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and colon, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
id Related Disease Score Top Affiliating Genes
1 acute cholangitis 30.1 ABCB11 ABCB4 ALB CD40LG CFTR CLDN1
2 gastric ulcer 29.9 ALB IL6 TNF
3 pericholangitis 29.6 ABCB4 CRP DLAT TNF
4 lymphedema 29.6 ALB F2 GGT1 GPT
5 granulomatous hepatitis 29.4 CRP F2 IL6
6 alopecia 29.4 ALB F2 GPT IL6 TNF
7 lymphoma 29.2 ALB CD40LG DLAT IL6 TNF
8 pyelonephritis 29.1 CFTR CRP F2 TNF
9 polyarteritis nodosa 29.0 ALB CEACAM5 CRP TNF
10 hepatocellular carcinoma 28.6 ALB CEACAM5 F2 GGT1 GPT IL6
11 systemic lupus erythematosus 27.8 ALB CD40LG CRP HLA-DRB1 IL6 TNF
12 cholangitis, primary sclerosing 12.4
13 ascending cholangitis 12.3
14 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 12.2
15 sclerosing cholangitis 12.2
16 secondary sclerosing cholangitis 12.2
17 primary biliary cholangitis 12.1
18 sclerosing cholangitis, neonatal 12.0
19 suppurative cholangitis 12.0
20 igg4-related sclerosing cholangitis 12.0
21 chronic cholangitis 11.9
22 follicular cholangitis and pancreatitis 11.8
23 isolated neonatal sclerosing cholangitis 11.7
24 bile duct carcinoma 11.2
25 cholecystitis 11.1
26 primary biliary cirrhosis 11.1
27 opisthorchiasis 11.1
28 succinic semialdehyde dehydrogenase deficiency 10.9 CLDN1 DCDC2
29 congenital dyserythropoietic anemia 10.8 ALB TNF
30 non-hodgkin lymphoma, during pregnancy 10.8 ALB F2
31 cholangiocarcinoma, susceptibility to 10.7
32 caroli disease 10.7
33 clonorchiasis 10.7
34 immunodeficiency, primary, autosomal recessive, il21r-related 10.7
35 localized chondrosarcoma 10.7 ALB FUT2 HLA-DRB1
36 argyria 10.7 F2 GPT
37 not otherwise specified 3-mga-uria type 10.7 CFTR HLA-DRB1 TNF
38 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
39 campylobacteriosis 10.6 ABCB4 GGT1 GPT
40 female infertility of uterine origin 10.6 ALB F2 GPT
41 biemond syndrome 10.6 HLA-DRB1 TNF
42 acute lymphocytic leukemia 10.6 ALB F2 GPT
43 anencephaly and spina bifida x-linked 10.5 HLA-DRB1 IL6 TNF
44 lymphocytic colitis 10.5 HLA-DRB1 IL6 TNF
45 dermatomyositis 10.5 ABCB4 ALB GPT
46 moderately severe hemophilia b 10.5 F2 HLA-DRB1 TNF
47 aortic arch interruption 10.5 IL6 TNF
48 rete ovarii adenoma 10.5 ALB F2 TNF
49 migraine with brainstem aura 10.5 HLA-DRB1 TNF
50 middle ear carcinoma 10.5 ALB CD40LG

Comorbidity relations with Cholangitis via Phenotypic Disease Network (PDN): (show all 17)


Acute Cystitis Acute Pancreatitis
Biliary Tract Neoplasm Cholecystitis
Cholestasis Deficiency Anemia
Familial Atrial Fibrillation Gallbladder Cancer
Heart Disease Hepatitis
Intrahepatic Gall Duct Cancer Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Primary Biliary Cirrhosis
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to Cholangitis

Symptoms & Phenotypes for Cholangitis

MGI Mouse Phenotypes related to Cholangitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ABCB11 ABCB4 ALB CA2 CD40LG CFTR
2 digestive/alimentary MP:0005381 9.97 IL6 TNF ABCB4 ALB CA2 CFTR
3 endocrine/exocrine gland MP:0005379 9.97 ABCB4 ALB CA2 CD40LG CFTR GGT1
4 immune system MP:0005387 9.9 ABCB4 CA2 CD40LG CFTR CRP F2
5 liver/biliary system MP:0005370 9.5 ABCB11 ABCB4 ALB CFTR GPBAR1 IL6
6 reproductive system MP:0005389 9.28 CFTR F2 FUT2 GGT1 IL6 TNF

Drugs & Therapeutics for Cholangitis

Drugs for Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
4
Cefoxitin Approved Phase 4 35607-66-0 441199
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
7
Vancomycin Approved Phase 4,Phase 3,Phase 1 1404-90-6 441141 14969
8
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
9
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11
Ofloxacin Approved Phase 4 82419-36-1 4583
12
chenodeoxycholic acid Approved Phase 4,Phase 3 474-25-9 10133
13
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
14
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
16
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
17 Temocillin Investigational Phase 4 66148-78-5
18 Amoxicillin-Potassium Clavulanate Combination Phase 4
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 2
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Antitubercular Agents Phase 4
23 Clavulanic Acid Phase 4
24 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
25 Antiparasitic Agents Phase 4,Phase 1
26 Antiprotozoal Agents Phase 4,Phase 1
27 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
28 Cytochrome P-450 Enzyme Inhibitors Phase 4
29 Topoisomerase Inhibitors Phase 4,Phase 2
30 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Antibodies Phase 4,Phase 2,Phase 1
32 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
33 Antirheumatic Agents Phase 4,Phase 1,Phase 2
34 glucocorticoids Phase 4,Phase 1
35 Hormone Antagonists Phase 4,Phase 1
36 Hormones Phase 4,Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1
38 Immunoglobulins Phase 4,Phase 2,Phase 1
39 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Bile Acids and Salts Phase 4,Phase 2,Phase 1
41 Renal Agents Phase 4
42 Cathartics Phase 4,Phase 3
43 Laxatives Phase 4,Phase 3
44 Antineoplastic Agents, Hormonal Phase 4
45 Methylprednisolone acetate Phase 4
46 Methylprednisolone Hemisuccinate Phase 4
47 Prednisolone acetate Phase 4
48 Prednisolone hemisuccinate Phase 4
49 Prednisolone phosphate Phase 4
50 penicillins Phase 4

Interventional clinical trials:

(show top 50) (show all 175)

id Name Status NCT ID Phase Drugs
1 Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice Unknown status NCT00731419 Phase 4
2 Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis Unknown status NCT01820026 Phase 4 Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
3 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
4 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
5 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
6 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
7 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
8 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Recruiting NCT02605213 Phase 4 Vancomycin;Placebo
9 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
10 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Recruiting NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
11 Leflunomide for Maintenance of Remission in IgG4 Related Disease Recruiting NCT02703194 Phase 4 Prednisone;Leflunomide
12 A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis Active, not recruiting NCT02464020 Phase 4 Vancomycin
13 Temocillin Pharmacokinetics in Paediatrics Not yet recruiting NCT02260102 Phase 4 Temocillin
14 The INFECIR-2 Albumin Prevention Study Terminated NCT02034279 Phase 4 Albumin
15 Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis Unknown status NCT01398917 Phase 3
16 Probiotics in Patients With Primary Sclerosing Cholangitis Unknown status NCT00161148 Phase 3 Probiotics
17 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
18 Trial of High-dose Urso in Primary Sclerosing Cholangitis Completed NCT00059202 Phase 2, Phase 3 Ursodeoxycholic Acid
19 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
20 The Effect of Bezafibrate on Cholestatic Itch Recruiting NCT02701166 Phase 3 Bezafibrate;Placebo
21 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3 Bezafibrate;Ursodeoxycholic Acid;Placebo (for Bezafibrate)
22 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer Recruiting NCT02170090 Phase 3 Gemcitabine;Cisplatin;Capecitabine
23 Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects Active, not recruiting NCT01802073 Phase 3 Oral Vancomycin
24 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Active, not recruiting NCT01473524 Phase 3 Obeticholic Acid (OCA);Placebo
25 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) Not yet recruiting NCT03301506 Phase 2, Phase 3 Seladelpar 2 mg Capsule;Seladelpar 5 mg Capsule;Seladelpar 10 mg Capsule
26 Efficacy and Safety of Vedolizumab Intravenous (IV) in the Treatment of Primary Sclerosing Cholangitis in Subjects With Underlying Inflammatory Bowel Disease Withdrawn NCT03035058 Phase 3 Vedolizumab;Placebo
27 Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
28 Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP Completed NCT02098486 Phase 2 Moxifloxacin;ceftriaxone
29 Phase 2 Study of NGM282 in Patients With Primary Sclerosing Cholangitis Completed NCT02704364 Phase 2
30 Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis Completed NCT01755507 Phase 2 norUDCA;Placebo
31 Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis Completed NCT02061540 Phase 2 LUM001
32 Phase II Pilot Study of Cladribine (2-Chlorodeoxyadenosine; 2-CdA) for Early Stage Primary Sclerosing Cholangitis Completed NCT00004762 Phase 2 cladribine
33 Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Subjects With Primary Sclerosing Cholangitis (PSC) Completed NCT01672853 Phase 2
34 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
35 Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis Recruiting NCT01688024 Phase 2 Mitomycin C;Normal saline
36 A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis Recruiting NCT02239211 Phase 2 BTT1023
37 Study of E6011 in Japanese Subjects With Primary Biliary Cholangitis Inadequately Responding to Ursodeoxycholic Acid Recruiting NCT03092765 Phase 2 E6011;Placebo
38 A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis Recruiting NCT02978339 Phase 1, Phase 2 Curcumin
39 Safety, Tolerability, and Efficacy of GS-9674 in Adults With Primary Sclerosing Cholangitis Without Cirrhosis Recruiting NCT02943460 Phase 2 GS-9674;Placebo to match GS-9674
40 Safety, Tolerability, and Efficacy of GS 9674 in Adults With Primary Biliary Cholangitis Without Cirrhosis Recruiting NCT02943447 Phase 2 GS-9674;Placebo to match GS-9674
41 Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid Recruiting NCT03124108 Phase 2 Elafibranor 80 mg;Elafibranor 120 mg;Placebo
42 A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of LJN452 in PBC Patients Recruiting NCT02516605 Phase 2 LJN452;Placebo
43 Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT02955602 Phase 2 MBX-8025 2 mg Capsule;MBX-8025 5 mg Capsule;MBX-8025 10 mg Capsule
44 Study to Assess Safety and Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Recruiting NCT03226067 Phase 2 GKT137831;Placebo oral capsule
45 Dose Response Study of GSK2330672 for the Treatment of Pruritus in Patients With Primary Biliary Cholangitis Recruiting NCT02966834 Phase 2 Placebo;GSK2330672
46 Haemodynamic Stability of Ketamine/Propofol Admixture "Ketofol" in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography Recruiting NCT02618668 Phase 2 Ketamine / Propofol Admixture;Propofol
47 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
48 Safety and Tumoricidal Effect of Low Dose Foscan PDT in Patients With Inoperable Bile Duct Cancers Recruiting NCT03003065 Phase 2 Temoporfin
49 PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Subjects With Primary Sclerosing Cholangitis Active, not recruiting NCT02653625 Phase 2 Cenicriviroc 150 mg
50 Obeticholic Acid (OCA) in Primary Sclerosing Cholangitis (PSC) Active, not recruiting NCT02177136 Phase 2 OCA;Placebo

Search NIH Clinical Center for Cholangitis

Cochrane evidence based reviews: cholangitis

Genetic Tests for Cholangitis

Genetic tests related to Cholangitis:

id Genetic test Affiliating Genes
1 Cholangitis 29

Anatomical Context for Cholangitis

MalaCards organs/tissues related to Cholangitis:

39
Liver, T Cells, Colon, Neutrophil, Testes, Thyroid, B Cells

Publications for Cholangitis

Articles related to Cholangitis:

(show top 50) (show all 1639)
id Title Authors Year
1
Acute suppurative cholangitis due to an impacted pancreatic stone: a rare adverse event in the setting of chronic calcifiedA pancreatitis. ( 28842170 )
2017
2
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
3
Retraction notice to: PS124-Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (PSC) in Individuals with Inflammatory Bowel Disease [J Hepatol 64 (2016) S199]. ( 28042931 )
2017
4
Acute Cholangitis After Bilioenteric Anastomosis for Bile Duct Injuries. ( 28744740 )
2017
5
Comparison of acute cholangitis with or without common bile duct dilatation. ( 28587432 )
2017
6
Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. ( 28419764 )
2017
7
A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients. ( 28056976 )
2017
8
Clinical Features, Response to Treatment, and Outcomes ofA IgG4-Related Sclerosing Cholangitis. ( 28111336 )
2017
9
Very Severe Secondary Sclerosing Cholangitis as a Sequela of Influenza. ( 28683859 )
2017
10
Recurrent gastric ulcer and cholangitis caused by ectopic drainage of the bile duct into the stomach. ( 28868226 )
2017
11
Primary biliary cholangitis: new treatments for an old disease. ( 28839882 )
2017
12
Endoscopic-ultrasonography-guided biliary drainage for repetitive acute cholangitis of the accessory hepatic duct obstructed by clipping during laparoscopic cholecystectomy. ( 28381783 )
2017
13
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
14
Genetic Risk Factors for Autoimmune Thyroid Disease might Affect the Susceptibility to and Modulate the Progression of Primary Biliary Cholangitis. ( 28922436 )
2017
15
Complete resolution of extensive xanthomas associated with primary sclerosing cholangitis following liver transplantation. ( 28940652 )
2017
16
Comparison between real-time tissue elastography and vibration-controlled transient elastography for the assessment of liver fibrosis and disease progression in patients with primary biliary cholangitis. ( 28044427 )
2017
17
Updates on primary sclerosing cholangitis. ( 28079751 )
2017
18
Isolated IgG4-related sclerosing cholangitis misdiagnosed as malignancy in an area with endemic cholangiocarcinoma: a case report. ( 28202062 )
2017
19
Endoscopic Retrograde Cholangiopancreatography (ERCP) and Acute Cholangitis: The Sooner, the Better. ( 28697150 )
2017
20
Feline Cholangitis. ( 28069287 )
2017
21
Poor response of initial steroid therapy for IgG4-related sclerosing cholangitis with multiple organs affected. ( 28328835 )
2017
22
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2017
23
Primary biliary cholangitis in 2016: High-definition PBC: biology, models and therapeutic advances. ( 28074075 )
2017
24
Cholangiocarcinoma and its mimickers in primary sclerosing cholangitis. ( 28951947 )
2017
25
Endoscopic management of acute cholangitis according to the TG13. ( 28425666 )
2017
26
Association between primary biliary cholangitis and osteoporosis: meta-analysis. ( 28948408 )
2017
27
Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. ( 28062665 )
2017
28
Impact of Crohn's Disease Duration on the Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. ( 28050039 )
2017
29
Acquired Leukocyte Inclusion Bodies Resembling DAPhle Bodies During Acute Cholangitis. ( 28747290 )
2017
30
Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis. ( 28941291 )
2017
31
Secondary Sclerosing Cholangitis: a Review of Recent Literature. ( 28752474 )
2017
32
Case report: A female case of isolated IgG4-related sclerosing cholangitis mimicking cholangiocarcinoma. ( 28422840 )
2017
33
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: consider primary biliary cholangitis not always primary sclerosing cholangitis. ( 28951510 )
2017
34
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. ( 28055006 )
2017
35
Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia. ( 28856582 )
2017
36
Primary sclerosing cholangitis - a comprehensive review. ( 28802875 )
2017
37
Endoscopic management of recurrent pyogenic cholangitis. ( 28068684 )
2017
38
One case that developed bile duct cancer all over the progress of repeated cholangitis. ( 28070100 )
2017
39
Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study. ( 28299343 )
2017
40
Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. ( 28892096 )
2017
41
Endpoints in the design of clinical trials for primary sclerosing cholangitis. ( 28847513 )
2017
42
Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis. ( 28839442 )
2017
43
The risk predictive values of UK-PBC and GLOBE scoring system in Chinese patients with primary biliary cholangitis: the additional effect of anti-gp210. ( 28083929 )
2017
44
MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. ( 28922472 )
2017
45
Seladelpar (MBX-8025), a selective PPAR-I' agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study. ( 28818518 )
2017
46
Coexistent Primary Biliary Cholangitis with CREST Syndrome (Reynolds Syndrome). ( 28602872 )
2017
47
Management of acute cholangitis as a result of occlusion from a self-expandable metallic stent in patients with malignant distal and hilar biliary obstructions. ( 28425663 )
2017
48
Generalised pustular psoriasis and neutrophilic cholangitis: An infrequently reported association with excellent response to tumour necrosis factor inhibitors. ( 28195322 )
2017
49
MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. ( 28886078 )
2017
50
Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis. ( 28943450 )
2017

Variations for Cholangitis

Expression for Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for Cholangitis

GO Terms for Cholangitis

Cellular components related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ALB CA2 CD40LG CRP F2 GGT1
2 extracellular exosome GO:0070062 9.4 ABCB11 ABCB4 ALB CA2 CEACAM5 CFTR
3 external side of plasma membrane GO:0009897 9.35 CD40LG F2 HLA-DRB1 IL6 TNF
4 intercellular canaliculus GO:0046581 9.26 ABCB11 ABCB4

Biological processes related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.37 ABCB11 CFTR
2 response to dexamethasone GO:0071548 9.32 ABCB4 CLDN1
3 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.26 IL6 TNF
4 regulation of immunoglobulin secretion GO:0051023 9.16 CD40LG TNF
5 acute-phase response GO:0006953 9.13 CRP F2 IL6
6 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF

Molecular functions related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.8 ABCB11 ABCB4 CFTR

Sources for Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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