MCID: CHL066
MIFTS: 45

Cholangitis malady

Gastrointestinal diseases category

Aliases & Classifications for Cholangitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
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Cholangitis, Aliases & Descriptions:

Name: Cholangitis 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:9446
ICD9CM27 576.1
MeSH33 D002761
NCIt38 C26718
ICD1025 K83.0

Summaries for Cholangitis

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Disease Ontology:9 A bile duct disease that is an inflammation of the bile duct.

MalaCards based summary: Cholangitis is related to primary biliary cirrhosis and ulcerative colitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Selected targets of HNF1 and Selected targets of C EBPalpha. The compounds lactulose and glycyrrhizin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and t cells, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Related Diseases for Cholangitis

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Diseases in the Cholangitis family:

Chronic Cholangitis Acute Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1primary biliary cirrhosis31.5CFTR, ABCB4
2ulcerative colitis31.3BPI, CTSG, LTF
3hepatitis31.3GPT, SLC17A5, LTF
4pancreatitis31.1LTF, SLC17A5, CFTR, ABCB4
5choledocholithiasis31.1GPT, SLC17A5
6autoimmune hepatitis31.0GPT, SLC17A5
7inflammatory bowel disease30.8BPI, NR1I2, CTSG, LTF
8obstructive jaundice30.8GPT, SLC17A5
9cholelithiasis30.7GPT, ABCB4
10acute pancreatitis30.6SLC17A5, GPT, CFTR
11liver disease30.6ABCB4, HLA-C, HP
12portal hypertension30.5GPT, SLC17A5
13polyarteritis nodosa30.3LTF
14liver cirrhosis30.2GPT, HP, SLC17A5
15pneumonia30.2CFTR, BPI, CTSG
16hepatitis b30.1GPT, SLC17A5
17bronchiectasis30.0CFTR, BPI, CTSG
18thrombocytopenia30.0GPT, HP, SLC17A5
19cholestasis29.8ABCB4, ABCC2, GPT, NR1I2, SLC17A5
20cystic fibrosis29.7LTF, CTSG, HP, BPI, CFTR, ABCC2
21arthritis29.6LTF, CTSG, HP, HLA-C
22hepatocellular carcinoma29.6ABCB4, ABCC2, GPT, NR1I2, SLC17A5
23intrahepatic cholestasis29.5ABCB4, ABCC2, NR1I2, SLC17A5
24fatty liver disease29.3ABCC2, GPT, HP, NR1I2, SLC17A5
25cholangitis, primary sclerosing29.1ABCB4, ABCC2, HLA-C, CFTR, GPT, BPI
26hepatitis c29.1ABCC2, HLA-C, GPT, HP, SLC17A5
27sclerosing cholangitis11.3
28acute cholangitis11.0
29colitis10.8
30suppurative cholangitis10.8
31cholangiocarcinoma10.7
32ascending cholangitis10.7
33autoimmune pancreatitis10.7
34cholecystitis10.6
35chronic cholangitis10.5
36ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.5
37crohn's disease10.4
38biliary atresia10.4
39duodenitis10.3
40mastitis10.3LTF, HP
41bacteremia10.3
42retroperitoneal fibrosis10.3
43pyridoxine deficiency10.3GPT, SLC17A5
44colorectal cancer10.3
45bile duct carcinoma10.3
46acute liver failure10.3SLC17A5, GPT
47acute kidney failure10.3GPT, HP
48keratoconjunctivitis sicca10.3CFTR, LTF
49scrub typhus10.3GPT, SLC17A5
50alcoholic hepatitis10.2GPT, SLC17A5

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Symptoms for Cholangitis

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Drugs & Therapeutics for Cholangitis

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Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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MalaCards organs/tissues related to Cholangitis:

31
Liver, Colon, T cells, Thyroid, Testes, Neutrophil, Pancreas, Bone, Kidney, B cells, Lymph node, Lung, Myeloid, Bone marrow, Heart, Salivary gland

Animal Models for Cholangitis or affiliated genes

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MGI Mouse Phenotypes related to Cholangitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.3LTF, ABCB4, ABCC2, CFTR, HP, NR1I2
2MP:00053767.2ABCC2, CFTR, CLDN1, HP, NR1I2, SLC17A5

Publications for Cholangitis

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Articles related to Cholangitis:

(show top 50)    (show all 1323)
idTitleAuthorsYear
1
DOP087. Intestinal microbial signature in patients with primary sclerosing cholangitis. (25718303)
2015
2
Dedicator of cytokinesis 8 deficiency: A predisposition to sclerosing cholangitis. (25220305)
2014
3
Reply to intrapancreatic biliary stricture in autoimmune pancreatitis should not be included in IgG4-related sclerosing cholangitis. (25207661)
2014
4
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
5
Primary Sclerosing Cholangitis: Current and Future Management Strategies. (23682242)
2013
6
Effects of immunosuppression and liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. (23376317)
2013
7
Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis. (23528654)
2013
8
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
9
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
10
Extended Spectrum-I^-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis. (22866257)
2012
11
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
12
Primary sclerosing cholangitis and distribution of inflammatory bowel disease. (22835578)
2012
13
Taenia saginata a rare cause of acute cholangitis: a case report. (23340150)
2012
14
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
15
Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans. (21934101)
2012
16
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
17
Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity. (22098817)
2012
18
Factors that reduce health-related quality of life in patients with primary sclerosing cholangitis. (22343690)
2012
19
Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment. (23075867)
2012
20
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. (21134112)
2011
21
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
22
Electrostatic modifications of the human leukocyte antigen DR P9 peptide-binding pocket in primary sclerosing cholangitis: back to the future with human leukocyte antigen DRI^. (21538433)
2011
23
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
24
Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. (21893134)
2011
25
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
26
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
27
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
28
Acute cholangitis due to pancreatic metastasis from squamous cell lung carcinoma: a case report and review of literature. (20062690)
2009
29
Long-term treatment of primary sclerosing cholangitis in children with oral vancomycin: an immunomodulating antibiotic. (18607270)
2008
30
Current concept about postoperative cholangitis in biliary atresia. (18402246)
2008
31
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. (17335678)
2007
32
Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines. (17252295)
2007
33
Efficacy and safety of early laparoscopic common bile duct exploration as primary procedure in acute cholangitis caused by common bile duct stones. (17907977)
2007
34
Primary sclerosing cholangitis. (17440311)
2007
35
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (16638702)
2006
36
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
37
Acute cholangitis caused by intra-biliary rupture of pancreatic hydatid cyst. (15453052)
2004
38
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis. (15215889)
2004
39
Acute cholangitis. (12957832)
2003
40
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
41
Primary sclerosing cholangitis in a child. (10365542)
1999
42
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
43
The role of endoscopic papillotomy in ascending cholangitis. (2053744)
1991
44
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
45
Ultrasonography of acute obstructive suppurative cholangitis: serial observation by ultrasound. (3106424)
1987
46
Trimethoprim-sulfamethoxazole treatment of cholangitis complicating congenital hepatic fibrosis. (3523453)
1986
47
Acute suppurative cholangitis secondary to malignant obstruction. (7284909)
1981
48
Acute obstructive suppurative cholangitis. (5782750)
1969
49
Acute suppurative cholangitis with recovery after the use of penicillin and streptomycin. (18862498)
1948
50
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)
1931

Variations for Cholangitis

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Expression for genes affiliated with Cholangitis

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Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

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Compounds for genes affiliated with Cholangitis

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Compounds related to Cholangitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1lactulose439.5LTF, SLC17A5, GPT
2glycyrrhizin43 2810.4GPT, LTF, SLC17A5
3adefovir439.4ABCC2, GPT, SLC17A5
4tenofovir43 49 1211.4SLC17A5, ABCC2, GPT
5malondialdehyde439.4GPT, HP, CTSG, SLC17A5
6ribavirin43 49 1211.2LTF, GPT, HP, SLC17A5
7vitamin-e439.2SLC17A5, HP, NR1I2, GPT
8vitamin b12439.2SLC17A5, LTF, HP, GPT
9neopterin439.2LTF, HP, SLC17A5, GPT
10carbohydrates439.2CFTR, HP, LTF, CTSG
11chenodeoxycholic acid43 28 24 1212.2GPT, NR1I2, ABCC2, ABCB4
12ezetimibe43 1210.2ABCC2, GPT, SLC17A5
13glycocholate439.2SLC17A5, ABCB4, ABCC2, GPT
14thyroxine43 2410.1SLC17A5, NR1I2, GPT, HP
15nevirapine43 49 1211.1GPT, SLC17A5, HLA-C
16lamivudine43 49 1211.1GPT, ABCC2, SLC17A5
17clotrimazole28 43 24 1212.1ABCC2, NR1I2, CFTR
18hyaluronic acid43 2410.0SLC17A5, GPT, HP, LTF
19acetaminophen43 2 49 24 1212.9ABCC2, GPT, NR1I2, SLC17A5
20phospholipid438.9HP, ABCB4, SLC17A5, BPI, CTSG
21phenobarbital43 28 49 1211.9NR1I2, SLC17A5, GPT, ABCC2
22verapamil43 28 49 24 1212.8SLC17A5, ABCB4, ABCC2, CFTR, GPT
23endotoxin438.8CTSG, LTF, BPI, SLC17A5, HP
24fibrinogen438.8CTSG, SLC17A5, HP, GPT, LTF
25lactate438.8BPI, SLC17A5, GPT, CTSG, HP
26vitamin a43 24 1210.8GPT, SLC17A5, LTF, NR1I2, HP
27epinephrine43 24 1210.7CFTR, HP, CTSG, ABCC2, SLC17A5
28rosuvastatin43 49 28 1211.7SLC17A5, GPT, ABCC2
29ursodeoxycholic acid43 24 1210.7SLC17A5, NR1I2, ABCB4, GPT, ABCC2
30tacrolimus43 49 1210.7GPT, NR1I2, SLC17A5, ABCC2, ABCB4
31methotrexate49 43 1210.7SLC17A5, GPT, NR1I2, ABCC2, ABCB4
32actinomycin d438.6HP, LTF, ABCC2, CFTR, BPI
33cholesterol43 28 24 1211.5HP, NR1I2, ABCB4, BPI, SLC17A5, GPT
34n acetylcysteine438.5LTF, SLC17A5, GPT, CFTR, ABCC2
35sodium43 249.4CFTR, ABCC2, HP, GPT, SLC17A5, CTSG
36urea43 24 1210.4GPT, BPI, HP, CTSG, SLC17A5, ABCC2
37dexamethasone43 49 28 1211.3NR1I2, CFTR, ABCB4, ABCC2, HP, LTF
38heparin43 28 24 1211.3SLC17A5, CTSG, HP, LTF, BPI
39aspartate438.2GPT, LTF, SLC17A5, CTSG, HP, CFTR
40rifampicin43 28 5910.2SLC17A5, GPT, HP, NR1I2, LTF, ABCC2
41glutamate438.1ABCC2, GPT, HP, SLC17A5, LTF, CFTR
42glucose438.1HP, SLC17A5, NR1I2, CTSG, GPT, BPI
43nitric oxide43 24 1210.1HP, SLC17A5, ABCC2, BPI, NR1I2, CTSG
44estrogen438.1LTF, NR1I2, HP, CFTR, ABCB4, ABCC2
45atp43 289.0ABCC2, ABCB4, CFTR, NR1I2, CTSG, SLC17A5
46creatinine437.9GPT, CTSG, ABCC2, BPI, HP, LTF
47retinoic acid43 248.9LTF, CFTR, ABCC2, BPI, NR1I2, CTSG
48alanine437.8CFTR, LTF, SLC17A5, CTSG, BPI, GPT
49lipid437.6CTSG, ABCC2, SLC17A5, NR1I2, BPI, GPT
50cyclosporin a43 28 599.6GPT, HP, NR1I2, SLC17A5, LTF, CFTR

GO Terms for genes affiliated with Cholangitis

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Cellular components related to Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:00465819.6ABCC2, ABCB4
2apical plasma membraneGO:00163248.8ABCB4, ABCC2, CFTR, CLDN1
3integral component of plasma membraneGO:00058877.5SLC17A5, BPI, CLDN1, HLA-C, ABCC2, ABCB4
4extracellular vesicular exosomeGO:00700627.4HLA-C, GPT, BPI, HP, CTSG, LTF

Biological processes related to Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transportGO:00068108.9ABCB4, ABCC2, CFTR
2immune responseGO:00069558.9CTSG, BPI, HLA-C
3transmembrane transportGO:00550858.6SLC17A5, CFTR, ABCC2, ABCB4

Molecular functions related to Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:00426269.6ABCC2, ABCB4

Products for genes affiliated with Cholangitis

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Sources for Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet