MCID: CHL066
MIFTS: 57

Cholangitis malady

Gastrointestinal diseases category

Summaries for Cholangitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards: Cholangitis is related to pancreatitis and ulcerative colitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Bile secretion and ABC-family proteins mediated transport. The compounds creatinine and alanine have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A bilt duct disease that is an inflammation of the bile duct.

Aliases & Classifications for Cholangitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholangitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:9446
MeSH34 D002761
NCIt39 C26718
ICD9CM27 576.1
ICD1025 K83.0

Related Diseases for Cholangitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cholangitis family:

Chronic Cholangitis Acute Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.1MPO, LTF, ABCB4, CFTR, SLC17A5, GGT1
2ulcerative colitis31.1LTF, PRTN3, CTSG, BPI
3hepatitis31.1GPT, SLC17A5
4cholangiocarcinoma31.0ALPP, GGT1, SLPI
5inflammatory bowel disease30.8BPI, CTSG, MPO, PRTN3, NR1I2, MADCAM1
6primary biliary cirrhosis30.8CFTR, ABCB4
7autoimmune hepatitis30.8GPT, SLC17A5, GGT1
8primary sclerosing cholangitis30.7ABCC2, ABCB4, CFTR, SLPI, GGT1, ENO1
9cholecystitis30.7GPT
10acute pancreatitis30.6MPO, GPT, CFTR, SLC17A5
11choledocholithiasis30.6GPT, SLC17A5, GGT1, ALPP
12crohn's disease30.5MPO, MADCAM1
13biliary atresia30.5GGT1, GPT
14liver cirrhosis30.3HP, GPT, SLPI, SLC17A5, GGT1
15obstructive jaundice30.3ALPP, GGT1
16cystic fibrosis30.3BPI, SLPI, CFTR, ABCC2, HP, LTF
17pancreatic cancer30.3ENO1, GGT1, CFTR, HP
18colorectal cancer30.3ALPP, ABCC2, LTF
19thyroiditis30.3HLA-C
20cholestasis30.1NR1I2, GPT, ABCC2, ABCB4, SLPI, SLC17A5
21cholelithiasis30.1GPT, ABCB4, GGT1, ALPP
22hepatocellular carcinoma30.0NR1I2, GPT, ABCC2, ABCB4, SLC17A5, GGT1
23psoriasis30.0SLPI, LTF, HLA-C
24adenocarcinoma30.0ENO1, GGT1, ABCC2
25hepatitis b30.0GPT, SLPI, SLC17A5, GGT1
26portal hypertension30.0GPT, SLC17A5, GGT1
27sarcoidosis30.0HLA-C, ALPP
28gallbladder disease30.0GGT1
29hypertension30.0GGT1
30hepatitis c29.9LTF, HP, GPT, ABCC2, ABCB4, SLC17A5
31arthritis29.9ALPP, HP, LTF, PRTN3, MPO, HLA-C
32pneumonia29.9SLPI, CFTR, MPO, CTSG, BPI
33obesity29.9GGT1, SLC17A5, GPT
34colon cancer29.9CFTR, LTF
35myeloma29.9ALPP
36intrahepatic cholestasis29.7NR1I2, ABCC2, ABCB4, SLC17A5, GGT1, ALPP
37bronchiectasis29.7CFTR, MPO, CTSG, BPI, SLPI
38systemic lupus erythematosus29.7CTSG, MPO, PRTN3, LTF, ENO1, ALPP
39thrombocytopenia29.7HP, GPT, SLPI, SLC17A5, ALPP
40fatty liver disease29.7GGT1
41alcoholic liver cirrhosis29.7GPT, SLC17A5, GGT1
42churg-strauss syndrome29.7MPO, PRTN3, LTF
43nephrotic syndrome29.7HP
44cholera29.7MADCAM1, CFTR, ALPP
45kawasaki disease29.7GPT
46sjogren's syndrome29.7LTF, PRTN3
47sclerosing cholangitis11.2
48acute cholangitis11.0
49suppurative cholangitis10.8
50ascending cholangitis10.6

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Clinical Features for Cholangitis

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Drugs & Therapeutics for Cholangitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholangitis

Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Search CenterWatch for Cholangitis

Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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32MalaCards
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MalaCards organs/tissues related to Cholangitis:

32
Liver, Colon, Small intestine, T cells, Testes, Thyroid, Pancreas, Bone, B cells, Lung, Myeloid, Lymph node, Kidney, Bone marrow, Heart, Salivary gland

Animal Models for Cholangitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholangitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7GGT1, CTSG, MPO, PRTN3, MADCAM1, LTF
2MP:000539710.7SLPI, GGT1, CFTR, ABCC2, HP, LTF
3MP:000537010.6CFTR, ABCB4, ABCC2, HP, LTF, NR1I2
4MP:000537610.5LTF, MPO, NR1I2, HP, CLDN1, ABCC2

Publications for Cholangitis

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50PubMed
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Articles related to Cholangitis:

(show top 50)    (show all 1246)
idTitleAuthorsYear
1
Radiologic course of primary sclerosing cholangitis: Assessment by three-dimensional magnetic resonance cholangiography and predictive features of progression. (23857427)
2014
2
Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis. (23528654)
2013
3
Incidence of colorectal cancer after liver transplantation for primary sclerosing cholangitis: a systematic review and meta-analysis. (24019127)
2013
4
Cholangitis and multiple liver abscesses after percutaneous ethanol injection (PEI) for recurrent hepatocellular carcinoma (HCC). (23659512)
2013
5
Diagnosis of sclerosing cholangitis in children: blinded, comparative study of magnetic resonance versus endoscopic cholangiography. (23830985)
2013
6
Primary sclerosing cholangitis is associated with autoreactive IgA antibodies against biliary epithelial cells. (23713804)
2013
7
An update on primary sclerosing cholangitis:from pathogenesis to treatment. (23478243)
2013
8
Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. (23981074)
2013
9
Colonic neoplasia in young patients with inflammatory bowel disease and primary sclerosing cholangitis. (22712545)
2013
10
Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis. (23811304)
2013
11
Escherichia coli infection induces autoimmune cholangitis and antimitochondrial antibodies in NOD.B6 (Idd10/Idd18) mice: Clin Exp Immunol - used Patrick's E. Coli 9-9-13.enl. (24128311)
2013
12
A unique clinical phenotype of primary sclerosing cholangitis associated with Crohn's disease. (22325171)
2012
13
Intrabiliary rapamycin may slow progression of primary sclerosing cholangitis. (22248428)
2012
14
Abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza A-associated ARDS. (23259907)
2012
15
Newly developed autoimmune cholangitis without relapse of autoimmune pancreatitis after discontinuing prednisolone. (23139619)
2012
16
Primary sclerosing cholangitis and bile acids. (23141889)
2012
17
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
18
Medical therapy for primary sclerosing cholangitis. (21981734)
2011
19
Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma. (21674559)
2011
20
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis. (21910728)
2011
21
Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from primary sclerosing cholangitis or cholangiocarcinoma. (21699807)
2011
22
A case of severe acute pancreatitis and cholangitis presenting as initial complaints of hepatocellular carcinoma. (21873799)
2011
23
Microbiology and antibiotic susceptibility of organisms in bile cultures from patients with and without cholangitis at an Asian academic medical center. (21348769)
2011
24
Sclerosing cholangitis: pediatric perspective. (20425475)
2010
25
Unique features of primary sclerosing cholangitis in children. (20393280)
2010
26
Optimal timing of elective laparoscopic cholecystectomy after acute cholangitis and subsequent clearance of choledocholithiasis. (20381787)
2010
27
Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype. (20645982)
2010
28
The Diagnostic Value of Endoscopic Balloon Catheter Usage for Detecting Early-Stage Primary Sclerosing Cholangitis in Endoscopic Retrograde Cholangiopancreatography: A Case Report. (21103219)
2010
29
Bedside ERCP without fluoroscopy in a case with acute cholangitis and impaired general status. (20084582)
2009
30
Ursodeoxycholic acid in primary sclerosing cholangitis: meta-analysis of randomized controlled trials. (19467021)
2009
31
Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis. (19096754)
2009
32
Autoimmune hemolytic anemia in a young adult with Crohn's disease and primary sclerosing cholangitis: An unusual association. (21172258)
2009
33
Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. (19065673)
2009
34
Marked eosinophilia as the first manifestation of sclerosing cholangitis. (19687582)
2009
35
Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis. (19475683)
2009
36
Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. (18452147)
2008
37
An unusual presentation of primary sclerosing cholangitis. (19034983)
2008
38
Autoimmune hepatitis 2 years after the diagnosis of primary sclerosing cholangitis: an unusual overlap syndrome in a 17-year-old adolescent. (18301306)
2008
39
Diagnosing cholangiocarcinoma in primary sclerosing cholangitis: an "evidence based radiology" review. (17874262)
2008
40
An autopsy case showing massive fibrinoid necrosis of the portal tracts of the liver with cholangiographic findings similar to those of primary sclerosing cholangitis. (17278236)
2007
41
Correlation between findings on MRCP and gadolinium-enhanced MR of the liver and a survival model for primary sclerosing cholangitis. (17410447)
2007
42
Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis. (17100974)
2007
43
Azithromycin may reduce cholestasis in primary sclerosing cholangitis: a case report and serendipitous observation. (18179759)
2007
44
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (16638702)
2006
45
Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis. (16371935)
2005
46
Biliary papillomatosis complicating recurrent pyogenic cholangitis. (11446759)
2001
47
Identification and characterization of autoantibodies against catalase and alpha-enolase in patients with primary sclerosing cholangitis. (9649223)
1998
48
The significance of nonvisualization of extrahepatic bile duct in intravenous radionuclide cholescintigraphy with special reference to acute suppurative cholangitis. (6467762)
1984
49
Cryptogenic acute cholangitis--association with toxic shock syndrome. (7293977)
1981
50
Cholangitis complicating congenital hepatic fibrosis. (1155419)
1975

Genetic Variations for Cholangitis

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Expression for genes affiliated with Cholangitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Cholangitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6ABCC2, ABCB4, CFTR
2
Hide members
10.6ABCC2, ABCB4, CFTR
310.6NR1I2, ABCC2, ABCB4
410.6MPO, NR1I2, ABCC2
510.5MPO, ABCC2

Compounds for genes affiliated with Cholangitis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Cholangitis according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1creatinine4411.2LTF, HP, GPT, ABCC2, SLC17A5, GGT1
2alanine4411.2ALPP, BPI, CTSG, PRTN3, LTF, HP
3cyclosporin a44 28 5913.2ABCC2, GPT, HP, LTF, NR1I2, ABCB4
4retinoic acid44 2412.2MPO, CTSG, CFTR, ABCC2, NR1I2, BPI
5lipid4411.2GGT1, BPI, CTSG, PRTN3, HP, SLC17A5
6lactate4411.2SLC17A5, GGT1, ALPP, SLPI, GPT, HP
7aspartate4411.1SLC17A5, MADCAM1, CTSG, ALPP, CFTR, ABCB4
8urea44 11 2413.1ABCC2, GGT1, SLPI, GPT, HP, CTSG
9rifampicin44 28 5913.1SLC17A5, GGT1, NR1I2, LTF, HP, GPT
10ursodeoxycholic acid44 11 2413.1NR1I2, ALPP, GPT, ABCC2, SLC17A5, ABCB4
11cholesterol44 28 11 2414.1GGT1, SLC17A5, SLPI, GPT, HP, NR1I2
12ascorbic acid44 2412.1LTF, MPO, SLPI, HP, CFTR, SLC17A5
13vitamin b124411.1ALPP, MPO, GPT, SLC17A5, HP, GGT1
14malondialdehyde4411.1HP, SLPI, CTSG, SLC17A5, GPT, GGT1
15verapamil44 49 28 11 2415.1CFTR, GPT, ABCB4, ABCC2, SLC17A5, GGT1
16hyaluronic acid44 2412.1SLC17A5, PRTN3, GGT1, LTF, SLPI, GPT
17serine4411.1MPO, ALPP, LTF, NR1I2, PRTN3, HP
18carbamazepine44 49 1113.0MPO, NR1I2, ABCC2, SLC17A5, GGT1, ALPP
19heparin44 28 11 2414.0SLPI, LTF, HP, CTSG, BPI, MPO
20dexamethasone44 49 28 1114.0ALPP, ABCC2, LTF, NR1I2, GGT1, ABCB4
21phenobarbital44 28 1113.0ALPP, SLC17A5, ABCC2, NR1I2, GPT, GGT1
22n acetylcysteine4411.0GPT, ABCC2, CFTR, GGT1, MPO, LTF
23cisplatin44 49 59 1114.0MPO, GGT1, ALPP, SLC17A5, SLPI, NR1I2
24sevoflurane44 1112.0SLC17A5, GGT1, ALPP, GPT, SLPI
25nitric oxide44 11 2413.0BPI, CTSG, NR1I2, MADCAM1, HP, SLC17A5
26bezafibrate44 28 1113.0ABCB4, SLC17A5, GPT, ALPP, GGT1
27tamoxifen44 49 28 1114.0LTF, SLC17A5, ABCC2, NR1I2, ALPP, SLPI
28fibrinogen4411.0SLPI, CTSG, HP, SLC17A5, ENO1, LTF
29ethanol44 49 11 2414.0PRTN3, GGT1, SLC17A5, SLPI, GPT, HP
30phosphorus4411.0ALPP, GGT1, SLC17A5, SLPI, GPT
31glycocholate4411.0GPT, ABCB4, ABCC2, SLC17A5
32superoxide44 2412.0SLPI, SLC17A5, ENO1, LTF, NR1I2
33aminopyrine4411.0GGT1, SLC17A5, GPT, MPO
34ribavirin44 49 1112.9HP, SLC17A5, GPT, LTF, GGT1
35phenytoin44 49 28 1113.9ALPP, SLC17A5, ABCC2, NR1I2, GGT1
36thyroxine44 2411.9SLC17A5, NR1I2, HP, GPT, GGT1, ALPP
37endotoxin4410.9BPI, CTSG, LTF, HP, SLPI, SLC17A5
38h2o24410.9GGT1, SLC17A5, CTSG, MPO, LTF, HP
39tacrolimus44 49 1112.9ABCC2, GPT, SLC17A5, GGT1, NR1I2, ABCB4
40dmso4410.8ALPP, SLC17A5, CFTR, PRTN3, MPO, NR1I2
41nevirapine44 49 1112.8HLA-C, GGT1, GPT, SLC17A5
42glutamate4410.8GPT, ABCC2
43acetaminophen44 2 49 11 2414.8GGT1, SLC17A5, ABCC2, GPT, NR1I2
44vitamin a44 11 2412.7HP, NR1I2, LTF
45cysteine4410.7ALPP, CFTR, SLPI, CTSG, GGT1, BPI
46estrogen4410.6ABCC2, ABCB4, LTF, PRTN3
47methotrexate44 49 1112.6NR1I2, GPT, ABCC2, ABCB4, SLC17A5, GGT1
48uric acid44 2411.6SLPI
49vitamin-e4410.5GGT1, GPT, HP, SLC17A5, NR1I2
50atp44 2811.4CFTR, ABCB4, SLPI, NR1I2, SLC17A5, CTSG

GO Terms for genes affiliated with Cholangitis

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16Gene Ontology
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Cellular components related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6SLC17A5, BPI, HLA-C, CLDN1, ABCB4, ABCC2
2secretory granuleGO:03014110.6CTSG, MPO, LTF
3apical plasma membraneGO:01632410.6CLDN1, CFTR, ABCB4, ABCC2
4intercellular canaliculusGO:04658110.4ABCC2, ABCB4
5plasma membraneGO:00588610.4ALPP, PRTN3, ENO1, CTSG, GGT1, CFTR

Products for genes affiliated with Cholangitis

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  • Antibodies
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Sources for Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet