MCID: CHL066
MIFTS: 54

Cholangitis malady

Gastrointestinal diseases category
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Summaries for Cholangitis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards: Cholangitis is related to primary sclerosing cholangitis and hepatitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Selected targets of HNF1 and Selected targets of C EBPalpha. The compounds lactulose and glycyrrhizin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Disease Ontology:8 A bile duct disease that is an inflammation of the bile duct.

Aliases & Classifications for Cholangitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholangitis 8 10 45 62


External Ids:

Disease Ontology8 DOID:9446
ICD9CM27 576.1
NCIt40 C26718
MeSH35 D002761
ICD1025 K83.0

Related Diseases for Cholangitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cholangitis family:

Chronic Cholangitis Acute Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1primary sclerosing cholangitis31.4LTF, CTSG, BPI, GPT, CFTR, HLA-C
2hepatitis31.2GPT, SLC17A5
3ulcerative colitis31.2BPI, LTF, CTSG
4pancreatitis31.2SLC17A5, LTF, ABCB4, CFTR
5primary biliary cirrhosis31.1CFTR, ABCB4
6inflammatory bowel disease30.9LTF, BPI, CTSG, NR1I2
7autoimmune hepatitis30.9GPT, SLC17A5
8choledocholithiasis30.7GPT, SLC17A5
9obstructive jaundice30.5GPT, SLC17A5
10acute pancreatitis30.5GPT, SLC17A5, CFTR
11cholelithiasis30.3GPT, ABCB4
12portal hypertension30.2GPT, SLC17A5
13cystic fibrosis30.2LTF, BPI, CTSG, HP, ABCC2, CFTR
14sepsis30.2BPI, NR1I2, CTSG, LTF
15cholestasis30.1NR1I2, SLC17A5, ABCC2, GPT, ABCB4
16pneumonia30.0BPI, CFTR, CTSG
17hepatitis b30.0GPT, SLC17A5
18hepatocellular carcinoma30.0GPT, SLC17A5, NR1I2, ABCB4, ABCC2
19arthritis29.9LTF, CTSG, HP, HLA-C
20bronchiectasis29.8CFTR, BPI, CTSG
21thrombocytopenia29.8GPT, HP, SLC17A5
22liver cirrhosis29.8HP, SLC17A5, GPT
23intrahepatic cholestasis29.7SLC17A5, ABCC2, ABCB4, NR1I2
24fatty liver disease29.6HP, NR1I2, ABCC2, SLC17A5, GPT
25hepatitis c29.6ABCC2, HP, HLA-C, GPT, SLC17A5
26sclerosing cholangitis11.3
27acute cholangitis11.0
28suppurative cholangitis10.8
29cholangiocarcinoma10.7
30ascending cholangitis10.7
31autoimmune pancreatitis10.6
32cholecystitis10.5
33chronic cholangitis10.5
34crohn's disease10.4
35ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.4
36biliary atresia10.4
37duodenitis10.3
38retroperitoneal fibrosis10.3
39liver disease10.3
40bile duct carcinoma10.3
41bacteremia10.3
42colorectal cancer10.2
43thyroiditis10.2
44cryptosporidiosis10.2
45ascariasis10.2
46pericholangitis10.2
47amyloidosis10.2
48congenital hepatic fibrosis10.2
49acalculous cholecystitis10.1
50intussusception10.1

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Symptoms for Cholangitis

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Drugs & Therapeutics for Cholangitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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33MalaCards
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MalaCards organs/tissues related to Cholangitis:

33
Liver, Colon, Small intestine, T cells, Thyroid, Testes, Pancreas, Bone, B cells, Myeloid, Lung, Kidney, Lymph node, Salivary gland, Heart, Bone marrow

Animal Models for Cholangitis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cholangitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.3LTF, ABCB4, ABCC2, CFTR, HP, NR1I2
2MP:00053767.2ABCC2, CFTR, CLDN1, HP, NR1I2, SLC17A5

Publications for Cholangitis

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Sources:
52PubMed
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Articles related to Cholangitis:

(show top 50)    (show all 1239)
idTitleAuthorsYear
1
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
2
Primary Sclerosing Cholangitis: Current and Future Management Strategies. (23682242)
2013
3
Effects of immunosuppression and liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. (23376317)
2013
4
Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis. (23528654)
2013
5
Updates in bacteriological epidemiology of community-acquired severe acute cholangitis and the effectiveness of metronidazole added routinely to the first-line antimicrobial regimen. (23708782)
2013
6
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
7
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
8
Extended Spectrum-I^-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis. (22866257)
2012
9
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
10
Primary sclerosing cholangitis and distribution of inflammatory bowel disease. (22835578)
2012
11
Taenia saginata a rare cause of acute cholangitis: a case report. (23340150)
2012
12
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
13
Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans. (21934101)
2012
14
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
15
Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity. (22098817)
2012
16
Factors that reduce health-related quality of life in patients with primary sclerosing cholangitis. (22343690)
2012
17
Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment. (23075867)
2012
18
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. (21134112)
2011
19
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
20
Electrostatic modifications of the human leukocyte antigen DR P9 peptide-binding pocket in primary sclerosing cholangitis: back to the future with human leukocyte antigen DRI^. (21538433)
2011
21
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
22
Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. (21893134)
2011
23
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
24
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
25
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
26
Acute cholangitis due to pancreatic metastasis from squamous cell lung carcinoma: a case report and review of literature. (20062690)
2009
27
Long-term treatment of primary sclerosing cholangitis in children with oral vancomycin: an immunomodulating antibiotic. (18607270)
2008
28
Current concept about postoperative cholangitis in biliary atresia. (18402246)
2008
29
Risk factors for recurrence of primary sclerosing cholangitis after liver transplantation. (18236405)
2008
30
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. (17335678)
2007
31
Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines. (17252295)
2007
32
Efficacy and safety of early laparoscopic common bile duct exploration as primary procedure in acute cholangitis caused by common bile duct stones. (17907977)
2007
33
Primary sclerosing cholangitis. (17440311)
2007
34
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (16638702)
2006
35
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
36
Acute cholangitis caused by intra-biliary rupture of pancreatic hydatid cyst. (15453052)
2004
37
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis. (15215889)
2004
38
Acute cholangitis. (12957832)
2003
39
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
40
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
41
Primary sclerosing cholangitis in a child. (10365542)
1999
42
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
43
The role of endoscopic papillotomy in ascending cholangitis. (2053744)
1991
44
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
45
Ultrasonography of acute obstructive suppurative cholangitis: serial observation by ultrasound. (3106424)
1987
46
Trimethoprim-sulfamethoxazole treatment of cholangitis complicating congenital hepatic fibrosis. (3523453)
1986
47
Acute suppurative cholangitis secondary to malignant obstruction. (7284909)
1981
48
Acute obstructive suppurative cholangitis. (5782750)
1969
49
Acute suppurative cholangitis with recovery after the use of penicillin and streptomycin. (18862498)
1948
50
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)
1931

Variations for Cholangitis

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Expression for genes affiliated with Cholangitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

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Sources:
50PathCards, 12EMD Millipore, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 30KEGG
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Compounds for genes affiliated with Cholangitis

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Cholangitis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1lactulose459.5LTF, SLC17A5, GPT
2glycyrrhizin45 2910.4GPT, LTF, SLC17A5
3adefovir459.4ABCC2, GPT, SLC17A5
4tenofovir45 51 1111.4SLC17A5, ABCC2, GPT
5malondialdehyde459.4GPT, HP, CTSG, SLC17A5
6ribavirin45 51 1111.2LTF, GPT, HP, SLC17A5
7vitamin-e459.2SLC17A5, HP, NR1I2, GPT
8vitamin b12459.2SLC17A5, LTF, HP, GPT
9neopterin459.2LTF, HP, SLC17A5, GPT
10carbohydrates459.2CFTR, HP, LTF, CTSG
11chenodeoxycholic acid45 29 24 1112.2GPT, NR1I2, ABCC2, ABCB4
12ezetimibe45 1110.2ABCC2, GPT, SLC17A5
13glycocholate459.2SLC17A5, ABCB4, ABCC2, GPT
14thyroxine45 2410.1SLC17A5, NR1I2, GPT, HP
15nevirapine45 51 1111.1GPT, SLC17A5, HLA-C
16lamivudine45 51 1111.1GPT, ABCC2, SLC17A5
17clotrimazole29 45 24 1112.1ABCC2, NR1I2, CFTR
18hyaluronic acid45 2410.0SLC17A5, GPT, HP, LTF
19acetaminophen45 3 51 24 1112.9ABCC2, GPT, NR1I2, SLC17A5
20phospholipid458.9HP, ABCB4, SLC17A5, BPI, CTSG
21phenobarbital45 29 51 1111.9NR1I2, SLC17A5, GPT, ABCC2
22verapamil45 29 51 24 1112.8SLC17A5, ABCB4, ABCC2, CFTR, GPT
23endotoxin458.8CTSG, LTF, BPI, SLC17A5, HP
24fibrinogen458.8CTSG, SLC17A5, HP, GPT, LTF
25lactate458.8BPI, SLC17A5, GPT, CTSG, HP
26vitamin a45 24 1110.8GPT, SLC17A5, LTF, NR1I2, HP
27epinephrine45 24 1110.7CFTR, HP, CTSG, ABCC2, SLC17A5
28rosuvastatin45 51 29 1111.7SLC17A5, GPT, ABCC2
29ursodeoxycholic acid45 24 1110.7SLC17A5, NR1I2, ABCB4, GPT, ABCC2
30tacrolimus45 51 1110.7GPT, NR1I2, SLC17A5, ABCC2, ABCB4
31methotrexate51 45 1110.7SLC17A5, GPT, NR1I2, ABCC2, ABCB4
32actinomycin d458.6HP, LTF, ABCC2, CFTR, BPI
33cholesterol45 29 24 1111.5HP, NR1I2, ABCB4, BPI, SLC17A5, GPT
34n acetylcysteine458.5LTF, SLC17A5, GPT, CFTR, ABCC2
35sodium45 249.4CFTR, ABCC2, HP, GPT, SLC17A5, CTSG
36urea45 24 1110.4GPT, BPI, HP, CTSG, SLC17A5, ABCC2
37dexamethasone45 51 29 1111.3NR1I2, CFTR, ABCB4, ABCC2, HP, LTF
38heparin45 29 24 1111.3SLC17A5, CTSG, HP, LTF, BPI
39aspartate458.2GPT, LTF, SLC17A5, CTSG, HP, CFTR
40rifampicin45 29 6110.2SLC17A5, GPT, HP, NR1I2, LTF, ABCC2
41glutamate458.1ABCC2, GPT, HP, SLC17A5, LTF, CFTR
42glucose458.1HP, SLC17A5, NR1I2, CTSG, GPT, BPI
43nitric oxide45 24 1110.1HP, SLC17A5, ABCC2, BPI, NR1I2, CTSG
44estrogen458.1LTF, NR1I2, HP, CFTR, ABCB4, ABCC2
45atp45 299.0ABCC2, ABCB4, CFTR, NR1I2, CTSG, SLC17A5
46creatinine457.9GPT, CTSG, ABCC2, BPI, HP, LTF
47retinoic acid45 248.9LTF, CFTR, ABCC2, BPI, NR1I2, CTSG
48alanine457.8CFTR, LTF, SLC17A5, CTSG, BPI, GPT
49lipid457.6CTSG, ABCC2, SLC17A5, NR1I2, BPI, GPT
50cyclosporin a45 29 619.6GPT, HP, NR1I2, SLC17A5, LTF, CFTR

GO Terms for genes affiliated with Cholangitis

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16Gene Ontology
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Cellular components related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:0465819.6ABCB4, ABCC2
2apical plasma membraneGO:0163248.8ABCB4, ABCC2, CFTR, CLDN1
3integral component of plasma membraneGO:0058877.5SLC17A5, BPI, CLDN1, HLA-C, ABCC2, ABCB4
4extracellular vesicular exosomeGO:0700627.4GPT, BPI, HP, CTSG, LTF, HLA-C

Biological processes related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transportGO:0068108.9CFTR, ABCB4, ABCC2
2immune responseGO:0069558.9BPI, CTSG, HLA-C
3transmembrane transportGO:0550858.6ABCB4, ABCC2, CFTR, SLC17A5

Molecular functions related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:0426269.6ABCC2, ABCB4

Products for genes affiliated with Cholangitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholangitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet