MCID: CHL066
MIFTS: 42

Cholangitis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholangitis

Aliases & Descriptions for Cholangitis:

Name: Cholangitis 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9446
ICD10 33 K83.0
ICD9CM 35 576.1
MeSH 42 D002761
NCIt 47 C26718
UMLS 69 C0008311

Summaries for Cholangitis

Disease Ontology : 12 A bile duct disease that is an inflammation of the bile duct.

MalaCards based summary : Cholangitis is related to acute cholangitis and hepatitis. An important gene associated with Cholangitis is CLDN1 (Claudin 1), and among its related pathways/superpathways are Influenza A and Cell adhesion molecules (CAMs). Affiliated tissues include liver, colon and t cells, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
id Related Disease Score Top Affiliating Genes
1 acute cholangitis 31.9 ABCB11 ABCB4 ALB CD40LG CFTR CLDN1
2 hepatitis 30.8 HLA-B HLA-DRB1 IL6 TNF
3 pericholangitis 29.7 ABCB4 CRP DLAT MPO TNF
4 crohn's colitis 29.6 IL6 MPO TNF
5 bile duct adenocarcinoma 29.4 ALB CD40LG
6 granulomatous hepatitis 29.4 CRP F2 IL6
7 celiac disease 29.4 CD40LG CRP HLA-B TNF
8 uveitis 29.4 CD40LG MPO TNF
9 pyelonephritis 29.3 CFTR CRP F2 TNF
10 tuberculosis 29.2 CD40LG IL6 TNF
11 bacterial meningitis 26.0 ABCB11 ABCB4 ALB CA2 CD40LG CFTR
12 cholangitis, primary sclerosing 12.5
13 ascending cholangitis 12.3
14 sclerosing cholangitis 12.2
15 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 12.2
16 primary biliary cholangitis 12.2
17 suppurative cholangitis 12.1
18 secondary sclerosing cholangitis 12.0
19 igg4-related sclerosing cholangitis 12.0
20 chronic cholangitis 11.9
21 follicular cholangitis and pancreatitis 11.8
22 isolated neonatal sclerosing cholangitis 11.7
23 cholecystitis 11.2
24 primary biliary cirrhosis 11.1
25 opisthorchiasis 11.1
26 caroli disease 10.9
27 clonorchiasis 10.8
28 cholangiocarcinoma, susceptibility to 10.8
29 immunodeficiency, primary, autosomal recessive, il21r-related 10.7
30 pancreatitis 10.4
31 colitis 10.4
32 congenital dyserythropoietic anemia 10.4 ALB TNF
33 sacral nerve root cysts 10.3 HLA-B HLA-DRB1
34 ulcerative colitis 10.3
35 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.3 MPO TNF
36 bickerstaff brainstem encephalitis 10.3 CFTR HLA-B HLA-DRB1
37 nondystrophic myotonia 10.3 ALB F2
38 aseptic meningitis 10.3 HLA-B HLA-DRB1 TNF
39 retroperitoneal germ cell neoplasm 10.3 ALB FUT2 HLA-DRB1
40 campylobacteriosis 10.3 GGT1 GPT MPO
41 female infertility of uterine origin 10.3 ALB F2 GPT
42 cataract 10.3 ALB CRP TNF
43 nystagmus, congenital motor, autosomal recessive 10.2 CFTR HLA-B HLA-DRB1 TNF
44 borderline leprosy 10.2 ABCB4 ALB GPT
45 acute monocytic leukemia 10.2 ALB F2 GPT
46 inflammatory bowel disease 10.2
47 hypertropia 10.2 ALB CRP TNF
48 atrophic vulva 10.2 ALB F2 MPO
49 ringed hair 10.2 GGT1 GPT
50 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF

Comorbidity relations with Cholangitis via Phenotypic Disease Network (PDN): (show all 17)


Acute Cystitis Acute Pancreatitis
Biliary Tract Neoplasm Cholecystitis
Cholestasis Deficiency Anemia
Familial Atrial Fibrillation Gallbladder Cancer
Heart Disease Hepatitis
Intrahepatic Gall Duct Cancer Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Postcholecystectomy Syndrome Primary Biliary Cirrhosis
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to Cholangitis

Symptoms & Phenotypes for Cholangitis

MGI Mouse Phenotypes related to Cholangitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ABCB11 ABCB4 ALB CA2 CD40LG CFTR
2 digestive/alimentary MP:0005381 9.97 ABCB4 ALB CA2 CFTR F2 FUT2
3 endocrine/exocrine gland MP:0005379 9.97 ALB CA2 CD40LG CFTR GGT1 GPBAR1
4 immune system MP:0005387 9.93 CA2 CD40LG CFTR CRP F2 FUT2
5 liver/biliary system MP:0005370 9.5 ABCB11 ABCB4 ALB CFTR GPBAR1 IL6
6 reproductive system MP:0005389 9.28 ABCB4 CA2 CD40LG CFTR F2 FUT2

Drugs & Therapeutics for Cholangitis

Search Clinical Trials , NIH Clinical Center for Cholangitis

Cochrane evidence based reviews: cholangitis

Genetic Tests for Cholangitis

Genetic tests related to Cholangitis:

id Genetic test Affiliating Genes
1 Cholangitis 29

Anatomical Context for Cholangitis

MalaCards organs/tissues related to Cholangitis:

39
Liver, Colon, T Cells, Testes, Neutrophil, Thyroid, Pancreas

Publications for Cholangitis

Articles related to Cholangitis:

(show top 50) (show all 1556)
id Title Authors Year
1
Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway. ( 28146070 )
2017
2
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. ( 28055006 )
2017
3
An Unusual Case of Cholangitis. ( 28061340 )
2017
4
Looking Into the Crystal Ball: Predicting Non-response to Ursodeoxycholic Acid in Primary Biliary Cholangitis. ( 28007481 )
2017
5
Primary biliary cholangitis in 2016: High-definition PBC: biology, models and therapeutic advances. ( 28074075 )
2017
6
Endoscopic management of recurrent pyogenic cholangitis. ( 28068684 )
2017
7
Knockout of the Primary Sclerosing Cholangitis-Risk Gene Fut2 Causes Liver Disease in Mice. ( 28056490 )
2017
8
A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients. ( 28056976 )
2017
9
Updates on primary sclerosing cholangitis. ( 28079751 )
2017
10
Primary biliary cholangitis-primary sclerosing cholangitis in an evolving overlap syndrome: A case report. ( 28089354 )
2017
11
Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. ( 28062665 )
2017
12
Impact of Crohn's Disease Duration on the Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. ( 28050039 )
2017
13
Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28076388 )
2017
14
One case that developed bile duct cancer all over the progress of repeated cholangitis. ( 28070100 )
2017
15
Retraction notice to: PS124-Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (PSC) in Individuals with Inflammatory Bowel Disease [J Hepatol 64 (2016) S199]. ( 28042931 )
2017
16
Comparison between real-time tissue elastography and vibration-controlled transient elastography for the assessment of liver fibrosis and disease progression in patients with primary biliary cholangitis. ( 28044427 )
2017
17
Feline Cholangitis. ( 28069287 )
2017
18
Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study. ( 28299343 )
2017
19
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
20
CCBE1 Mutation causing Sclerosing Cholangitis - Expanding the Spectrum of Lymphedema-Cholestasis Syndrome. ( 28073151 )
2017
21
The risk predictive values of UK-PBC and GLOBE scoring system in Chinese patients with primary biliary cholangitis: the additional effect of anti-gp210. ( 28083929 )
2017
22
Prevalence of inflammatory bowel disease among patients with primary sclerosing cholangitis in Iran. ( 27032493 )
2016
23
Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. ( 26864161 )
2016
24
IgG4-related Sclerosing Cholangitis with No Biliary Stricture but Severe Thickening of the Bile Duct Wall. ( 27301508 )
2016
25
Primary Sclerosing Cholangitis. ( 27653566 )
2016
26
The diagnosis of antimitochondrial antibody-negative primary biliary cholangitis. ( 27567165 )
2016
27
IgG4-related sclerosing cholangitis: all we need to know. ( 26817943 )
2016
28
Diagnosis, Treatment, and Monitoring of Patients With Primary Biliary Cholangitis. ( 27917095 )
2016
29
TAFRO syndrome showing cholangitis on liver biopsy. ( 28090015 )
2016
30
Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis. ( 27860118 )
2016
31
No Evidence That Azathioprine Increases Risk ofA Cholangiocarcinoma in Patients With Primary SclerosingA Cholangitis. ( 27521513 )
2016
32
Acute cholangitis: An unexpected cause of fever of unknown origin diagnosed by (18)F-FDG PET/CT. ( 27033744 )
2016
33
Gut and liver T cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. ( 27647428 )
2016
34
Positive antimitochondrial antibody but normal serum alkaline phosphatase levels: Can it be primary biliary cholangitis? ( 27572231 )
2016
35
Shifting Paradigms: What Is the True Prevalence and Clinical Course of Primary Sclerosing Cholangitis? ( 27590692 )
2016
36
Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis: Prospective comparative study. ( 27759652 )
2016
37
Safe laparoscopic clearance of the common bile duct in emergently admitted patients with choledocholithiasis and cholangitis. ( 27212991 )
2016
38
IgG4+ B-Cell Receptor Clones Distinguish IgG4-Related Disease from Primary Sclerosing Cholangitis and Biliary/Pancreatic Malignancies. ( 27015613 )
2016
39
IgG4-Related Sclerosing Cholangitis. ( 27466792 )
2016
40
Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients. ( 27919851 )
2016
41
An Update on Cancer Risk and Surveillance in Primary Sclerosing Cholangitis. ( 28028930 )
2016
42
Obeticholic acid in primary biliary cholangitis. ( 27825634 )
2016
43
The Microbiome and Primary Sclerosing Cholangitis. ( 27997974 )
2016
44
Molecular diagnostic testing for primary biliary cholangitis. ( 27460480 )
2016
45
A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. ( 27893675 )
2016
46
Early Molecular Stratification of High-risk Primary Biliary Cholangitis. ( 27913155 )
2016
47
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD. ( 27207975 )
2016
48
Leonardo da Vinci's Mona Lisaa8^: Medical Differentials and Primary Biliary Cholangitis. ( 27821036 )
2016
49
CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood. ( 27630216 )
2016
50
Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly. ( 27729744 )
2016

Variations for Cholangitis

Expression for Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for Cholangitis

GO Terms for Cholangitis

Cellular components related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ALB CA2 CD40LG CRP F2 GGT1
2 external side of plasma membrane GO:0009897 9.55 CD40LG F2 HLA-DRB1 IL6 TNF
3 extracellular exosome GO:0070062 9.44 ABCB11 ABCB4 ALB CA2 CFTR CRP
4 intercellular canaliculus GO:0046581 9.26 ABCB11 ABCB4

Biological processes related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CD40LG HLA-B HLA-DRB1 IL6 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.61 CRP IL6 TNF
3 interferon-gamma-mediated signaling pathway GO:0060333 9.58 HLA-B HLA-DRB1 SP100
4 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.48 ABCB11 CFTR
5 response to dexamethasone GO:0071548 9.37 ABCB4 CLDN1
6 response to yeast GO:0001878 9.32 IL6 MPO
7 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.26 IL6 TNF
8 regulation of immunoglobulin secretion GO:0051023 9.16 CD40LG TNF
9 acute-phase response GO:0006953 9.13 CRP F2 IL6
10 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF

Molecular functions related to Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.8 ABCB11 ABCB4 CFTR

Sources for Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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