MCID: CHL066
MIFTS: 57

Cholangitis malady

Gastrointestinal diseases category

Summaries for Cholangitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards: Cholangitis is related to pancreatitis and ulcerative colitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Bile secretion and ABC-family proteins mediated transport. The compounds creatinine and alanine have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A bilt duct disease that is an inflammation of the bile duct.

Aliases & Classifications for Cholangitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholangitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:9446
MeSH34 D002761
NCIt39 C26718
ICD9CM27 576.1
ICD1025 K83.0

Related Diseases for Cholangitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cholangitis family:

Chronic Cholangitis Acute Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.1MPO, LTF, ABCB4, CFTR, SLC17A5, GGT1
2ulcerative colitis31.1LTF, PRTN3, CTSG, BPI
3hepatitis31.1GPT, SLC17A5
4cholangiocarcinoma31.0ALPP, GGT1, SLPI
5inflammatory bowel disease30.8BPI, CTSG, MPO, PRTN3, NR1I2, MADCAM1
6primary biliary cirrhosis30.8CFTR, ABCB4
7autoimmune hepatitis30.8GPT, SLC17A5, GGT1
8primary sclerosing cholangitis30.7ABCC2, ABCB4, CFTR, SLPI, GGT1, ENO1
9cholecystitis30.7GPT
10acute pancreatitis30.6MPO, GPT, CFTR, SLC17A5
11choledocholithiasis30.6GPT, SLC17A5, GGT1, ALPP
12crohn's disease30.5MPO, MADCAM1
13biliary atresia30.5GGT1, GPT
14liver cirrhosis30.3HP, GPT, SLPI, SLC17A5, GGT1
15obstructive jaundice30.3ALPP, GGT1
16cystic fibrosis30.3BPI, SLPI, CFTR, ABCC2, HP, LTF
17pancreatic cancer30.3ENO1, GGT1, CFTR, HP
18colorectal cancer30.3ALPP, ABCC2, LTF
19thyroiditis30.3HLA-C
20cholestasis30.1NR1I2, GPT, ABCC2, ABCB4, SLPI, SLC17A5
21cholelithiasis30.1GPT, ABCB4, GGT1, ALPP
22hepatocellular carcinoma30.0NR1I2, GPT, ABCC2, ABCB4, SLC17A5, GGT1
23psoriasis30.0SLPI, LTF, HLA-C
24adenocarcinoma30.0ENO1, GGT1, ABCC2
25hepatitis b30.0GPT, SLPI, SLC17A5, GGT1
26portal hypertension30.0GPT, SLC17A5, GGT1
27sarcoidosis30.0HLA-C, ALPP
28gallbladder disease30.0GGT1
29hypertension30.0GGT1
30hepatitis c29.9LTF, HP, GPT, ABCC2, ABCB4, SLC17A5
31arthritis29.9ALPP, HP, LTF, PRTN3, MPO, HLA-C
32pneumonia29.9SLPI, CFTR, MPO, CTSG, BPI
33obesity29.9GGT1, SLC17A5, GPT
34colon cancer29.9CFTR, LTF
35myeloma29.9ALPP
36intrahepatic cholestasis29.7NR1I2, ABCC2, ABCB4, SLC17A5, GGT1, ALPP
37bronchiectasis29.7CFTR, MPO, CTSG, BPI, SLPI
38systemic lupus erythematosus29.7CTSG, MPO, PRTN3, LTF, ENO1, ALPP
39thrombocytopenia29.7HP, GPT, SLPI, SLC17A5, ALPP
40fatty liver disease29.7GGT1
41alcoholic liver cirrhosis29.7GPT, SLC17A5, GGT1
42churg-strauss syndrome29.7MPO, PRTN3, LTF
43nephrotic syndrome29.7HP
44cholera29.7MADCAM1, CFTR, ALPP
45kawasaki disease29.7GPT
46sjogren's syndrome29.7LTF, PRTN3
47sclerosing cholangitis11.2
48acute cholangitis11.0
49suppurative cholangitis10.8
50ascending cholangitis10.6

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Clinical Features for Cholangitis

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Drugs & Therapeutics for Cholangitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholangitis

Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Search CenterWatch for Cholangitis

Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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32MalaCards
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MalaCards organs/tissues related to Cholangitis:

32
Liver, Colon, Small intestine, T cells, Thyroid, Testes, Pancreas, Bone, B cells, Myeloid, Lung, Kidney, Lymph node, Salivary gland, Heart, Bone marrow

Animal Models for Cholangitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholangitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7GGT1, CTSG, MPO, PRTN3, MADCAM1, LTF
2MP:000539710.7MPO, MADCAM1, LTF, HP, ABCC2, CFTR
3MP:000537010.6CTSG, NR1I2, LTF, HP, ABCC2, ABCB4
4MP:000537610.5MPO, NR1I2, LTF, HP, CLDN1, ABCC2

Publications for Cholangitis

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50PubMed
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Articles related to Cholangitis:

(show top 50)    (show all 1246)
idTitleAuthorsYear
1
Diagnostic challenges of Wilson's disease presenting as acute pancreatitis, cholangitis, and jaundice. (24303094)
2013
2
Impact of ileal pouch-anal anastomosis on the surgical outcome of orthotopic liver transplantation for primary sclerosing cholangitis. (22789675)
2013
3
Sclerosing Cholangitis in BehAset's Disease. (24198838)
2013
4
Secondary Sclerosing Cholangitis due to Gallbladder Adenocarcinoma. (23626514)
2013
5
Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. (23054338)
2013
6
Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis. (23775876)
2013
7
Cholangitis in children with biliary atresia: Health-care resource utilisation. (24373065)
2013
8
Magnetic resonance (MR) imaging and MR cholangiopancreatography findings in cats with cholangitis and pancreatitis. (23143839)
2013
9
Baseline Values and Changes in Liver Stiffness, Measured by Transient Elastography, are Associated with Fibrosis Severity and Outcomes of Patients with Primary Sclerosing Cholangitis. (24389304)
2013
10
Recognition of other organ involvement might assist in the differential diagnosis of IgG4-associated sclerosing cholangitis without apparent pancreatic involvement: report of two cases. (22855009)
2012
11
Small duct autoimmune sclerosing cholangitis and Crohn colitis in a 10-year-old child. A case report and review of the literature. (22891962)
2012
12
Comparison of the clinical characteristics and imaging findings of acute cholangitis with and without biliary dilatation. (23175488)
2012
13
Usefulness of steroid administration for diagnosis of IgG4-related sclerosing cholangitis. (23343338)
2012
14
Endoscopic nasobiliary drainage and percutaneous transhepatic biliary drainage for the treatment of acute obstructive suppurative cholangitis: a retrospective study of 37 cases. (22591676)
2012
15
Image of the month: Fasciola hepatica as a cause of cholangitis. (22696768)
2012
16
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
17
The "Von Meyenburg complex": an unusual cause of cholangitis? (21852223)
2011
18
Mycosis as a cause of secondary sclerosing cholangitis requiring liver retransplantation. (21239959)
2011
19
Bile acids for primary sclerosing cholangitis. (21249655)
2011
20
Neonatal ichthyosis and sclerosing cholangitis syndrome: extremely variable liver disease severity from claudin-1 deficiency. (21865982)
2011
21
Clinical characteristics of ulcerative colitis associated with primary sclerosing cholangitis in Korea. (21830268)
2011
22
A dramatic response to a single dose of infliximab as rescue therapy in acute generalized pustular psoriasis of von Zumbusch associated with a neutrophilic cholangitis. (20148838)
2010
23
Does primary sclerosing cholangitis impact quality of life in patients with inflammatory bowel disease? (19637332)
2010
24
Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis. (19533132)
2009
25
Laparoscopically assisted ERCP in a case of acute cholangitis in a patient with biliopancreatic diversion with distal gastric preservation. (18815847)
2009
26
Impact of inflammatory bowel disease and ursodeoxycholic acid therapy on small-duct primary sclerosing cholangitis. (17992695)
2008
27
Silymarin in the treatment of patients with primary sclerosing cholangitis: an open-label pilot study. (17940903)
2008
28
Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience. (18446034)
2008
29
Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines. (17252295)
2007
30
Alopecia areata, primary sclerosing cholangitis, and ulcerative colitis: autoimmunity and apoptosis as common links? (17372831)
2007
31
Characteristics of primary sclerosing cholangitis in the USA. (17931206)
2007
32
Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function. (17719933)
2007
33
Recurrence of primary sclerosing cholangitis after living donor liver transplantation. (17241386)
2007
34
Systemic lupus erythematosus with concurrent protein-losing enteropathy and primary sclerosing cholangitis: a unique association. (16539281)
2006
35
Which patients with primary biliary cirrhosis or primary sclerosing cholangitis should undergo endoscopic screening for oesophageal varices detection? (15710991)
2005
36
Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo-controlled trial. (15565569)
2004
37
Endoscopic biliary drainage for severe acute cholangitis in biliary obstruction as a result of malignant and benign diseases. (15304115)
2004
38
Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients. (15288468)
2004
39
Does the addition of endoscopic sphincterotomy to stent insertion improve drainage of the bile duct in acute suppurative cholangitis? (14520292)
2003
40
Sarcoidosis with cholangitis component in a patient with autoimmune hemolytic anemia. (11062776)
2000
41
A revised natural history model for primary sclerosing cholangitis. (10907383)
2000
42
Biliary strictures and cholangitis secondary to ascariasis: endoscopic management. (10536331)
1999
43
Sclerosing cholangitis associated with hypereosinophilic syndrome. (9260773)
1997
44
Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. (8801203)
1996
45
Kawasaki disease manifesting with acute cholangitis. A case report. (1729732)
1992
46
Elevated serum levels of tumor marker CA19-9 in acute cholangitis. (3168694)
1988
47
Management of acute cholangitis and the impact of endoscopic sphincterotomy. (3790964)
1986
48
Latent chronic cholangitis in congenital hepatic fibrosis. (7160410)
1982
49
Acute abdomen due to acute cholangitis in a leukemic child. (1057764)
1975
50
Acute obstructive suppurative cholangitis. (5782750)
1969

Genetic Variations for Cholangitis

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Expression for genes affiliated with Cholangitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Cholangitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6CFTR, ABCB4, ABCC2
2
Hide members
10.6ABCC2, ABCB4, CFTR
310.6ABCB4, ABCC2, NR1I2
410.6ABCC2, NR1I2, MPO
510.5ABCC2, MPO

Compounds for genes affiliated with Cholangitis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Cholangitis according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1creatinine4411.2LTF, HP, GPT, ABCC2, SLC17A5, GGT1
2alanine4411.2ALPP, BPI, CTSG, PRTN3, LTF, HP
3cyclosporin a44 28 5913.2ABCC2, GPT, HP, LTF, NR1I2, ABCB4
4retinoic acid44 2412.2MPO, CTSG, CFTR, ABCC2, NR1I2, BPI
5lipid4411.2GGT1, BPI, CTSG, PRTN3, HP, SLC17A5
6lactate4411.2SLC17A5, GGT1, ALPP, SLPI, GPT, HP
7aspartate4411.1SLC17A5, MADCAM1, CTSG, ALPP, CFTR, ABCB4
8urea44 11 2413.1ABCC2, GGT1, SLPI, GPT, HP, CTSG
9rifampicin44 28 5913.1SLC17A5, GGT1, NR1I2, LTF, HP, GPT
10ursodeoxycholic acid44 11 2413.1NR1I2, ALPP, GPT, ABCC2, SLC17A5, ABCB4
11cholesterol44 28 11 2414.1GGT1, SLC17A5, SLPI, GPT, HP, NR1I2
12ascorbic acid44 2412.1LTF, MPO, SLPI, HP, CFTR, SLC17A5
13vitamin b124411.1ALPP, MPO, GPT, SLC17A5, HP, GGT1
14malondialdehyde4411.1HP, SLPI, CTSG, SLC17A5, GPT, GGT1
15verapamil44 49 28 11 2415.1CFTR, GPT, ABCB4, ABCC2, SLC17A5, GGT1
16hyaluronic acid44 2412.1SLC17A5, PRTN3, GGT1, LTF, SLPI, GPT
17serine4411.1MPO, ALPP, LTF, NR1I2, PRTN3, HP
18carbamazepine44 49 1113.0MPO, NR1I2, ABCC2, SLC17A5, GGT1, ALPP
19heparin44 28 11 2414.0SLPI, LTF, HP, CTSG, BPI, MPO
20dexamethasone44 49 28 1114.0ALPP, ABCC2, LTF, NR1I2, GGT1, ABCB4
21phenobarbital44 28 1113.0ALPP, SLC17A5, ABCC2, NR1I2, GPT, GGT1
22n acetylcysteine4411.0GPT, ABCC2, CFTR, GGT1, MPO, LTF
23cisplatin44 49 59 1114.0MPO, GGT1, ALPP, SLC17A5, SLPI, NR1I2
24sevoflurane44 1112.0SLC17A5, GGT1, ALPP, GPT, SLPI
25nitric oxide44 11 2413.0BPI, CTSG, NR1I2, MADCAM1, HP, SLC17A5
26bezafibrate44 28 1113.0ABCB4, SLC17A5, GPT, ALPP, GGT1
27tamoxifen44 49 28 1114.0LTF, SLC17A5, ABCC2, NR1I2, ALPP, SLPI
28fibrinogen4411.0SLPI, CTSG, HP, SLC17A5, ENO1, LTF
29ethanol44 49 11 2414.0PRTN3, GGT1, SLC17A5, SLPI, GPT, HP
30phosphorus4411.0ALPP, GGT1, SLC17A5, SLPI, GPT
31glycocholate4411.0GPT, ABCB4, ABCC2, SLC17A5
32superoxide44 2412.0SLPI, SLC17A5, ENO1, LTF, NR1I2
33aminopyrine4411.0GGT1, SLC17A5, GPT, MPO
34ribavirin44 49 1112.9HP, SLC17A5, GPT, LTF, GGT1
35phenytoin44 49 28 1113.9ALPP, SLC17A5, ABCC2, NR1I2, GGT1
36thyroxine44 2411.9SLC17A5, NR1I2, HP, GPT, GGT1, ALPP
37endotoxin4410.9BPI, CTSG, LTF, HP, SLPI, SLC17A5
38h2o24410.9GGT1, SLC17A5, CTSG, MPO, LTF, HP
39tacrolimus44 49 1112.9ABCC2, GPT, SLC17A5, GGT1, NR1I2, ABCB4
40dmso4410.8ALPP, SLC17A5, CFTR, PRTN3, MPO, NR1I2
41nevirapine44 49 1112.8HLA-C, GGT1, GPT, SLC17A5
42glutamate4410.8GPT, ABCC2
43acetaminophen44 2 49 11 2414.8GGT1, SLC17A5, ABCC2, GPT, NR1I2
44vitamin a44 11 2412.7HP, NR1I2, LTF
45cysteine4410.7ALPP, CFTR, SLPI, CTSG, GGT1, BPI
46estrogen4410.6ABCC2, ABCB4, LTF, PRTN3
47methotrexate44 49 1112.6NR1I2, GPT, ABCC2, ABCB4, SLC17A5, GGT1
48uric acid44 2411.6SLPI
49vitamin-e4410.5GGT1, GPT, HP, SLC17A5, NR1I2
50atp44 2811.4CFTR, ABCB4, SLPI, NR1I2, SLC17A5, CTSG

GO Terms for genes affiliated with Cholangitis

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Sources:
16Gene Ontology
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Cellular components related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6HLA-C, CLDN1, ABCC2, ABCB4, SLC17A5, BPI
2secretory granuleGO:03014110.6LTF, MPO, CTSG
3apical plasma membraneGO:01632410.6CFTR, ABCB4, ABCC2, CLDN1
4intercellular canaliculusGO:04658110.4ABCC2, ABCB4
5plasma membraneGO:00588610.4CTSG, HLA-C, PRTN3, MADCAM1, ABCC2, ABCB4

Products for genes affiliated with Cholangitis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet