MCID: CHL066
MIFTS: 50

Cholangitis malady

Gastrointestinal category

Summaries for Cholangitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards: Cholangitis is related to primary sclerosing cholangitis and ulcerative colitis. An important gene associated with Cholangitis is CLDN1 (claudin 1), and among its related pathways are Bile secretion and ABC-family proteins mediated transport. The compounds creatinine and alanine have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A bilt duct disease that is an inflammation of the bile duct.

Aliases & Classifications for Cholangitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

cholangitis 8 10 45 61


External Ids:

Disease Ontology8 DOID:9446
MeSH35 D002761
NCIt40 C26718
ICD9CM27 576.1
ICD1025 K83.0

Related Diseases for Cholangitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cholangitis family:

chronic cholangitis acute cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 272)
idRelated DiseaseScoreTop Affiliating Genes
1primary sclerosing cholangitis31.8ABCC2, ABCB4, CFTR, SLPI, GGT1, ENO1
2ulcerative colitis31.1LTF, PRTN3, CTSG, BPI
3hepatitis c30.9LTF, HP, GPT, ABCC2, ABCB4, SLC17A5
4primary biliary cirrhosis30.9CFTR, ABCB4
5autoimmune hepatitis30.8GPT, SLC17A5, GGT1
6crohn's disease30.6MPO, MADCAM1
7choledocholithiasis30.6GPT, SLC17A5, GGT1, ALPP
8acute pancreatitis30.6MPO, GPT, CFTR, SLC17A5
9biliary atresia30.6GGT1, GPT
10hepatitis b30.3GPT, SLPI, SLC17A5, GGT1
11obstructive jaundice30.3ALPP, GGT1
12bacteremia30.3SLPI, BPI
13cystic fibrosis30.3BPI, SLPI, CFTR, ABCC2, HP, LTF
14colorectal cancer30.3ALPP, ABCC2, LTF
15thyroiditis30.2HLA-C
16sepsis30.2BPI, CTSG, MPO, PRTN3, NR1I2, LTF
17cholelithiasis30.2GPT, ABCB4, GGT1, ALPP
18adenocarcinoma30.1ENO1, GGT1, ABCC2
19hepatitis e30.1GPT
20arthritis29.9ALPP, HP, LTF, PRTN3, MPO, HLA-C
21portal hypertension29.9GPT, SLC17A5, GGT1
22cholera29.9MADCAM1, CFTR, ALPP
23intrahepatic cholestasis29.7NR1I2, ABCC2, ABCB4, SLC17A5, GGT1, ALPP
24bronchiectasis29.7CFTR, MPO, CTSG, BPI, SLPI
25systemic lupus erythematosus29.7CTSG, MPO, PRTN3, LTF, ENO1, ALPP
26thrombocytopenia29.7HP, GPT, SLPI, SLC17A5, ALPP
27fatty liver disease29.7GGT1
28nephritis29.7MPO, PRTN3
29alcoholic liver cirrhosis29.7GPT, SLC17A5, GGT1
30churg-strauss syndrome29.7MPO, PRTN3, LTF
31kawasaki disease29.7GPT
32wilson disease29.7GPT, SLC17A5
33sjogren's syndrome29.7LTF, PRTN3
34sclerosing cholangitis11.3
35acute cholangitis11.0
36suppurative cholangitis10.8
37ascending cholangitis10.7
38autoimmune pancreatitis10.6
39chronic cholangitis10.6
40hepatitis a10.6
41hepatitis d10.4
42ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.4
43retroperitoneal fibrosis10.3
44bile duct carcinoma10.3
45ascariasis10.2
46cryptosporidiosis10.2
47pericholangitis10.2
48amyloidosis10.2
49congenital hepatic fibrosis10.2
50acalculous cholecystitis10.1

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to cholangitis

Clinical Features for Cholangitis

Drugs & Therapeutics for Cholangitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cholangitis

Drug clinical trials:

Search ClinicalTrials for Cholangitis

Search NIH Clinical Center for Cholangitis

Search CenterWatch for Cholangitis

Genetic Tests for Cholangitis

Anatomical Context for Cholangitis

Animal Models for Cholangitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cholangitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7GGT1, CTSG, MPO, PRTN3, MADCAM1, LTF
2MP:000539710.7SLPI, GGT1, CFTR, ABCC2, HP, LTF
3MP:000537010.6CFTR, ABCB4, ABCC2, HP, LTF, NR1I2
4MP:000537610.5LTF, MPO, NR1I2, HP, CLDN1, ABCC2

Publications for Cholangitis

Sources:
51PubMed
See all sources

Articles related to Cholangitis:

(show top 50)    (show all 1246)
idTitleAuthorsYear
1
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
2
Hepatolithiasis with secondary cholangitis and supernumerary left hepatic lobe. (24114828)
2013
3
Diagnostic and therapeutic value of ERCP in acute cholangitis. (23997958)
2013
4
Moving toward evidence-based liver allocation in patients with primary sclerosing cholangitis. (23447418)
2013
5
Inflammatory bowel disease in primary sclerosing cholangitis: a robust yet changing relationship. (23502353)
2013
6
Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study. (23384404)
2013
7
TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). (23307001)
2013
8
Lower bile duct stenosis caused by xanthogranulomatous cholangitis complicated with jaundice. (24286438)
2013
9
Platynosomum fastosum-induced chronic intrahepatic cholangitis and Spirometra spp. infections in feral cats from Grand Cayman. (21729387)
2012
10
Is antibiotic resistance microorganism becoming a significant problem in acute cholangitis in Korea? (22866247)
2012
11
Primary sclerosing cholangitis, Crohn's disease and HLA-B27 in black South African women. (23402092)
2012
12
Risk factors for post-ERCP cholangitis in patients with pancreatic cancer from a single referral center in Iran. (22799362)
2012
13
The value of thioredoxin family proteins and proliferation markers in dysplastic and malignant gallbladders in patients with primary sclerosing cholangitis. (22370917)
2012
14
A case of IgG4-related sclerosing cholangitis overlapped with primary biliary cirrhosis. (22790128)
2012
15
Endoscopic ultrasound as an early diagnostic tool for primary sclerosing cholangitis: a prospective pilot study. (22752890)
2012
16
A case of IgG4-related sclerosing cholangitis mimicking an intrahepatic cholangiocellular carcinoma. (22291208)
2012
17
Management of primary sclerosing cholangitis: conventions and controversies. (22590699)
2012
18
The best approach for diagnosing primary sclerosing cholangitis. (22086533)
2011
19
Increased risk of colorectal cancer and dysplasia in patients with Crohn's colitis and primary sclerosing cholangitis. (21979184)
2011
20
Primary sclerosing cholangitis patients with serial polysomy fluorescence in situ hybridization results are at increased risk of cholangiocarcinoma. (21844920)
2011
21
Education and imaging. Hepatobiliary and pancreatic: sclerosing cholangitis associated with critical illness. (20492345)
2010
22
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. (21170836)
2010
23
Paravaterian diverticula presenting as acute cholangitis in two very elderly patients. (20593062)
2010
24
Ulcerative colitis and primary sclerosing cholangitis as part of autoimmune polyglandular syndrome type III. (19322903)
2010
25
An update on cholangiocarcinoma associated with primary sclerosing cholangitis. (20216413)
2010
26
Immunoglobulin G4-associated sclerosing cholangitis mimicking cholangiocarcinoma. (20354252)
2010
27
Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization. (19094117)
2009
28
Gallbladder lymphoma in primary sclerosing cholangitis. (18848908)
2009
29
Prevalence of sclerosing cholangitis in adults with autoimmune hepatitis: a prospective magnetic resonance imaging and histological study. (19575454)
2009
30
Cholangiocarcinoma in primary sclerosing cholangitis. (19705300)
2009
31
The safety and effectiveness of endoscopic biliary decompression by plastic stent placement in acute suppurative cholangitis compared with nasobiliary drainage. (18635173)
2008
32
Clinically recurrent primary sclerosing cholangitis following liver transplantation: a time course. (18236392)
2008
33
Immune pathogenesis of sclerosing cholangitis in biliary atresia. (17931210)
2007
34
Rupture of a pancreaticoduodenal artery aneurysm into the common bile duct resulting in fatal suppurative cholangitis: report of a case. (15622474)
2005
35
Chronic cholangitis caused by Bordetella hinzii in a liver transplant recipient. (15131227)
2004
36
Acute cholangitis--predictive factors for emergency ERCP. (11564004)
2001
37
A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis. (11438501)
2001
38
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
39
Recurrent cholestatic jaundice associated with generalized pustular psoriasis: evidence for a neutrophilic cholangitis. (10905601)
2000
40
Acute (ascending) cholangitis. (10987108)
2000
41
Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis? (9791051)
1998
42
HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis. (7875491)
1995
43
Emergency endoscopic nasobiliary drainage for acute calculous suppurative cholangitis and its potential use in chemical dissolution. (8439660)
1993
44
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. (2218872)
1990
45
Ultrasonography of acute obstructive suppurative cholangitis: serial observation by ultrasound. (3106424)
1987
46
Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction. (646570)
1978
47
Ascending cholangitis: an urgent surgical problem. (4691603)
1973
48
Acute suppurative cholangitis due to ampullary fibrosis. (5469467)
1970
49
SUPPURATIVE CHOLANGITIS WITH MULTIPLE LIVER ABSCESS FORMATION DUE TO AEROBACTER AEROGENES AND STREPTOCOCCUS VIRIDANS: SUCCESSFUL TREATMENT WITH MASSIVE DOSES OF INTRAVENOUS PENICILLIN. (14329506)
1965
50
Suppurative cholangitis. (20284746)
1947

Genetic Variations for Cholangitis

Expression for genes affiliated with Cholangitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cholangitis

Search GEO for disease gene expression data for Cholangitis.

Pathways for genes affiliated with Cholangitis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Cholangitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6ABCC2, ABCB4, CFTR
2
Hide members
10.6ABCC2, ABCB4, CFTR
310.6NR1I2, ABCC2, ABCB4
410.6MPO, NR1I2, ABCC2
510.5MPO, ABCC2

Compounds for genes affiliated with Cholangitis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Cholangitis according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1creatinine4511.2LTF, HP, GPT, ABCC2, SLC17A5, GGT1
2alanine4511.2ALPP, BPI, CTSG, PRTN3, LTF, HP
3cyclosporin a45 29 6013.2ABCC2, GPT, HP, LTF, NR1I2, ABCB4
4retinoic acid45 2412.2MPO, CTSG, CFTR, ABCC2, NR1I2, BPI
5lipid4511.2GGT1, BPI, CTSG, PRTN3, HP, SLC17A5
6lactate4511.2SLC17A5, GGT1, ALPP, SLPI, GPT, HP
7aspartate4511.1SLC17A5, MADCAM1, CTSG, ALPP, CFTR, ABCB4
8urea45 11 2413.1ABCC2, GGT1, SLPI, GPT, HP, CTSG
9rifampicin45 29 6013.1SLC17A5, GGT1, NR1I2, LTF, HP, GPT
10ursodeoxycholic acid45 11 2413.1NR1I2, ALPP, GPT, ABCC2, SLC17A5, ABCB4
11cholesterol45 29 11 2414.1GGT1, SLC17A5, SLPI, GPT, HP, NR1I2
12ascorbic acid45 2412.1LTF, MPO, SLPI, HP, CFTR, SLC17A5
13vitamin b124511.1ALPP, MPO, GPT, SLC17A5, HP, GGT1
14malondialdehyde4511.1HP, SLPI, CTSG, SLC17A5, GPT, GGT1
15verapamil45 50 29 11 2415.1CFTR, GPT, ABCB4, ABCC2, SLC17A5, GGT1
16hyaluronic acid45 2412.1SLC17A5, PRTN3, GGT1, LTF, SLPI, GPT
17serine4511.1MPO, ALPP, LTF, NR1I2, PRTN3, HP
18carbamazepine45 50 1113.0MPO, NR1I2, ABCC2, SLC17A5, GGT1, ALPP
19heparin45 29 11 2414.0SLPI, LTF, HP, CTSG, BPI, MPO
20dexamethasone45 50 29 1114.0ALPP, ABCC2, LTF, NR1I2, GGT1, ABCB4
21phenobarbital45 29 1113.0ALPP, SLC17A5, ABCC2, NR1I2, GPT, GGT1
22n acetylcysteine4511.0GPT, ABCC2, CFTR, GGT1, MPO, LTF
23cisplatin45 50 60 1114.0MPO, GGT1, ALPP, SLC17A5, SLPI, NR1I2
24sevoflurane45 1112.0SLC17A5, GGT1, ALPP, GPT, SLPI
25nitric oxide45 11 2413.0BPI, CTSG, NR1I2, MADCAM1, HP, SLC17A5
26bezafibrate45 29 1113.0ABCB4, SLC17A5, GPT, ALPP, GGT1
27tamoxifen45 50 29 1114.0LTF, SLC17A5, ABCC2, NR1I2, ALPP, SLPI
28fibrinogen4511.0SLPI, CTSG, HP, SLC17A5, ENO1, LTF
29ethanol45 50 11 2414.0PRTN3, GGT1, SLC17A5, SLPI, GPT, HP
30phosphorus4511.0ALPP, GGT1, SLC17A5, SLPI, GPT
31glycocholate4511.0GPT, ABCB4, ABCC2, SLC17A5
32superoxide45 2412.0SLPI, SLC17A5, ENO1, LTF, NR1I2
33aminopyrine4511.0GGT1, SLC17A5, GPT, MPO
34ribavirin45 50 1112.9HP, SLC17A5, GPT, LTF, GGT1
35phenytoin45 50 29 1113.9ALPP, SLC17A5, ABCC2, NR1I2, GGT1
36thyroxine45 2411.9SLC17A5, NR1I2, HP, GPT, GGT1, ALPP
37endotoxin4510.9BPI, CTSG, LTF, HP, SLPI, SLC17A5
38h2o24510.9GGT1, SLC17A5, CTSG, MPO, LTF, HP
39tacrolimus45 50 1112.9ABCC2, GPT, SLC17A5, GGT1, NR1I2, ABCB4
40dmso4510.8ALPP, SLC17A5, CFTR, PRTN3, MPO, NR1I2
41nevirapine45 50 1112.8HLA-C, GGT1, GPT, SLC17A5
42glutamate4510.8GPT, ABCC2
43acetaminophen45 2 50 11 2414.8GGT1, SLC17A5, ABCC2, GPT, NR1I2
44vitamin a45 11 2412.7HP, NR1I2, LTF
45cysteine4510.7ALPP, CFTR, SLPI, CTSG, GGT1, BPI
46estrogen4510.6ABCC2, ABCB4, LTF, PRTN3
47methotrexate45 50 1112.6NR1I2, GPT, ABCC2, ABCB4, SLC17A5, GGT1
48uric acid45 2411.6SLPI
49vitamin-e4510.5GGT1, GPT, HP, SLC17A5, NR1I2
50atp45 2911.4CFTR, ABCB4, SLPI, NR1I2, SLC17A5, CTSG

GO Terms for genes affiliated with Cholangitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6HLA-C, CLDN1, ABCC2, ABCB4, SLC17A5, BPI
2secretory granuleGO:03014110.6LTF, MPO, CTSG
3apical plasma membraneGO:01632410.6CFTR, ABCB4, ABCC2, CLDN1
4intercellular canaliculusGO:04658110.4ABCC2, ABCB4
5plasma membraneGO:00588610.4CTSG, HLA-C, PRTN3, MADCAM1, ABCC2, ABCB4

Products for genes affiliated with Cholangitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholangitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet