MCID: CHL067
MIFTS: 53

Cholecystitis malady

Gastrointestinal category

Summaries for Cholecystitis

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Cholecystitis (Greek, -cholecyst, \"gallbladder\", combined with the suffix -itis, \"inflammation\") is... more...

MalaCards: Cholecystitis, also known as chronic cholecystitis, is related to acalculous cholecystitis and emphysematous cholecystitis. An important gene associated with Cholecystitis is CCK (cholecystokinin), and among its related pathways are Leukocyte transendothelial migration and Cell adhesion molecules (CAMs). The compounds asperlicin and 1,4-benzodiazepine have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A cholangitis that is an inflammation of the gallbladder.

Description from OMIM:47 600803

Aliases & Classifications for Cholecystitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 47OMIM, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

cholecystitis 8 43 22 10 45 61
chronic cholecystitis 8 45 61
acalculous cholecystitis 43 61
acute cholecystitis 8 45
acute cholecystitis unspecified 8
acute and chronic cholecystitis 8
acute on chronic cholecystitis 8
acute cholecystitis nos 8
gallstone cholecystitis 43
cholecystitis, acute 61


External Ids:

Disease Ontology8 DOID:1949
MeSH35 D002764
NCIt40 C34465
SNOMED-CT57 197414008, 76581006
OMIM47 600803
ICD9CM27 575.10

Related Diseases for Cholecystitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cholecystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1acalculous cholecystitis31.7TDH
2emphysematous cholecystitis31.4KRT81
3xanthogranulomatous cholecystitis31.3S100A9
4cholelithiasis30.9GPT, GUSB, CCK
5hepatitis c30.6CD40LG, CXCR6, GPT
6acute pancreatitis30.5GPT, CRP, CCK, CCKAR
7systemic lupus erythematosus30.4S100A9, GUSB, CRP, CD40LG
8choledocholithiasis30.4GPT, GUSB
9adenocarcinoma30.3CCKAR, CCK, S100A9, GUSB, MUC3A, CLDN2
10obstructive jaundice30.1CCK, GPT
11bacteremia30.1GUSB, CRP
12antiphospholipid syndrome30.1CD40LG
13scrub typhus30.1CD40LG, GPT
14infectious mononucleosis30.1CD40LG, GUSB
15duodenal ulcer29.9CCK
16crohn's disease29.7CRP
17kawasaki disease29.7GPT, CRP
18cystic fibrosis29.7S100A9, GUSB, MUC3A
19atherosclerosis29.7S100A9, CRP, CD40LG, CXCL16, CXCR6
20ulcerative colitis29.7CLDN2, MUC3A, CRP, GUSB
21acute cholangitis10.4
22hepatitis a10.4
23leptospirosis10.3
24appendicitis10.3
25typhoid fever10.3
26mirizzi syndrome10.2
27churg-strauss syndrome10.2
28hepatitis c virus10.2
29ascariasis10.2
30sclerosing cholangitis10.2
31aortic aneurysm10.2
32autoimmune pancreatitis10.2
33cholera10.1
34cholecystolithiasis10.1
35portal vein thrombosis10.1
36abdominal aortic aneurysm10.1
37acquired immunodeficiency syndrome10.1
38biliary tract disease10.1
39tuberculosis10.1
40typhus10.1
41vasculitis10.1
42cytomegalovirus infection10.1
43sepsis10.1
44polyarteritis nodosa10.1
45hepatitis b10.1
46plasmodium falciparum malaria10.1
47viral hepatitis10.1
48primary sclerosing cholangitis10.1
49hemorrhagic fever10.1
50thalassemia, hispanic gamma-delta-beta10.1

Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to cholecystitis

Clinical Features for Cholecystitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

600803

Drugs & Therapeutics for Cholecystitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cholecystitis

Drug clinical trials:

Search ClinicalTrials for Cholecystitis

Search NIH Clinical Center for Cholecystitis

Search CenterWatch for Cholecystitis

Genetic Tests for Cholecystitis

Sources:
22GTR
See all sources

Genetic tests related to Cholecystitis:

id Genetic test Affiliating Genes
1 Cholecystitis22

Anatomical Context for Cholecystitis

Animal Models for Cholecystitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cholecystitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.6CXCL16, CCK, S100A9, GUSB, CRP, F12

Publications for Cholecystitis

Sources:
51PubMed
See all sources

Articles related to Cholecystitis:

(show top 50)    (show all 1218)
idTitleAuthorsYear
1
Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis: a population-based propensity score analysis. (23979286)
2014
2
Xanthogranulomatous cholecystitis: A rare cause of digestive hemorrhage. (24411821)
2014
3
Outcomes of Xanthogranulomatous cholecystitis in laparoscopic era: A retrospective Cohort study. (24019688)
2013
4
Acalculous cholecystitis occurring in the context of Plasmodium malariae infection: a case report. (23889828)
2013
5
Salmonella cholecystitis: atypical presentation of a typical condition. (24169398)
2013
6
Laparoscopic cholecystectomy for acute cholecystitis: does timing matter? (24426450)
2013
7
Haemobilia causing cholangitis in a patient on dual anti-platelet treatment suffering from acute acalculous cholecystitis. (23466686)
2013
8
Hemorrhagic shock caused by rupture of cystic artery pseudoaneurysm secondary to calculous cholecystitis. (24286432)
2013
9
Changing trends and outcomes in the use of percutaneous cholecystostomy tubes for acute cholecystitis. (23263191)
2013
10
Migratory takotsubo cardiomyopathy in the setting of cholecystitis. (22795810)
2012
11
Percutaneous transhepatic gallbladder drainage changes emergency laparoscopic cholecystectomy to an elective operation in patients with acute cholecystitis. (22129145)
2011
12
Intramural gallstones mimicking typical lithiasic cholecystitis. (21079538)
2011
13
Acalculous cholecystitis in a patient with hepatocellular carcinoma on sorafenib. (21991498)
2011
14
Case report of xanthogranulomatous cholecystitis, review of its sonographic and magnetic resonance findings, and distinction from other gallbladder pathology. (22470787)
2011
15
Acute cholecystitis in a patient with metastatic renal cell carcinoma treated with everolimus. (20215482)
2011
16
Intrahepatic abscess secondary to acute calculous cholecystitis. (21647048)
2011
17
Failure to perform cholecystectomy for acute cholecystitis in elderly patients is associated with increased morbidity, mortality, and cost. (20421027)
2010
18
Endoscopic gallbladder drainage for management of acute cholecystitis. (20438890)
2010
19
Evolving treatment paradigms for acute cholecystitis: comment on "Surgical management of acute cholecystitis at a tertiary care center in the modern era". (20491161)
2010
20
Hepatitis a with pleural effusion, ascites and acalculous cholecystitis. (23056750)
2010
21
Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis? (20630515)
2010
22
Acute acalculous cholecystitis in children with Epstein-Barr virus infection: a role for Gilbert's syndrome? (19008138)
2009
23
Fatal acute acalculous cholecystitis as an early complication after radiation therapy.. (18457103)
2008
24
Cholecystitis as the initial manifestation of disseminated cryptococcosis. (17885305)
2007
25
Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature. (16610041)
2006
26
Significance of expression of epidermal growth factor (EGF) and its receptor (EGFR) in chronic cholecystitis and gallbladder carcinoma]. (12654182)
2003
27
Acute acalculous cholecystitis owing to salmonella sepsis. (14574527)
2003
28
Dengue fever with acute acalculous cholecystitis. (12887023)
2003
29
Xanthogranulomatous cholecystitis with a liver abscess and metastatic endophthalmitis: report of a case. (11991520)
2002
30
Hemobilia and jaundice caused by acalculous cholecystitis. (11782621)
2002
31
The use of USG spatial reconstructions in diagnosing cholelithiasis and cholecystitis. (11977321)
2001
32
An unusual presentation of acute cholecystitis: biliary ascariasis. (11436449)
2001
33
Acute acalculous cholecystitis complicating oral recontamination after allogeneic bone marrow transplantation. (21590149)
1997
34
Emphysematous cholecystitis. (9152163)
1997
35
MR imaging of xanthogranulomatous cholecystitis. (9132812)
1996
36
Acute acalculous cholecystitis as a complication of spinal cord injury. (8024434)
1994
37
Percutaneous transhepatic cholecystostomy for acute acalculous cholecystitis. (8252358)
1993
38
Acalculous cholecystitis. (2716024)
1989
39
Acalculous cholecystitis--a misnomer. (3210199)
1988
40
CT diagnosis of acalculous cholecystitis. (3805432)
1987
41
Gangrenous cholecystitis and acute cholangitis associated with anaerobic bacteria in bile. (2870920)
1986
42
Emphysematous cholecystitis as a complication of hepatic arterial embolization. (4016806)
1985
43
Factors encouraging laparotomy in acalculous cholecystitis. (3886289)
1985
44
Acalculous cholecystitis and fever related to total parenteral nutrition. (6437783)
1984
45
Acute acalculous cholecystitis complicating abdominal aortic aneurysm resection. (6502835)
1984
46
Acalculous cholecystitis: a case with variable cholescintigram. (6726421)
1984
47
Xanthogranulomatous cholecystitis. (7337158)
1981
48
Acute emphysematous cholecystitis. (4377171)
1974
49
Acute emphysematous cholecystitis. (4429938)
1974
50
Acute emphysematous cholecystitis. (13302599)
1956

Genetic Variations for Cholecystitis

Expression for genes affiliated with Cholecystitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for genes affiliated with Cholecystitis

Sources:
30KEGG, 52QIAGEN
See all sources

Pathways related to Cholecystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CLDN1, CLDN2, OCLN
210.1CLDN1, CLDN2, CD40LG, OCLN
3
Hide members
10.1OCLN, CLDN2, CLDN1, CXCL16, CXCR6

Compounds for genes affiliated with Cholecystitis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Cholecystitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1asperlicin4510.7CCKAR, CCK
21,4-benzodiazepine4510.7CCKAR, CCK
3lorglumide45 2911.7CCKAR, CCK
4l3652604510.7CCKAR, CCK
5ym0224510.7CCKAR, CCK
6dexloxiglumide45 2911.7CCKAR, CCK
7devazepide45 29 6012.7CCK, CCKAR
8caerulein4510.7CCK, CCKAR
9omeprazole45 29 50 11 2414.6CCKAR, CCK, CRP
10loxiglumide4510.6CCKAR, CCK
11bromosulfophthalein4510.6CCK, GPT
12ursodeoxycholic acid45 11 2412.6CCK, CD40LG, GPT
13lactulose4510.6GPT, CRP, GUSB, CCK
14benzodiazepines4510.6CCKAR, CCK
15vitamin b124510.6GUSB, CRP, CD40LG, GPT
16fenofibrate45 50 1112.6CRP, CD40LG, GPT
17cocaine45 1111.6CCKAR, CCK, CD40LG, GPT
18ivig4510.6CRP, CD40LG, GPT
19gamma globulin4510.6CRP, CD40LG
20erythromycin45 50 2 1113.6CCKAR, GUSB, CD40LG
21glycocholate4510.6GPT, GUSB
22aspirin45 50 29 2413.5CCK, GUSB, CRP, F12, CD40LG
23neopterin4510.5GPT, CD40LG, CRP
24hydroxychloroquine45 1111.5CRP, CD40LG
25pravastatin45 50 29 11 2414.5GPT, CD40LG, CRP
26fibrinogen4510.5S100A9, CRP, F12, CD40LG, GPT
27methotrexate45 50 1112.5GPT, MUC3A, CRP, S100A9
28d penicillamine4510.4GPT, CRP
29morphine45 50 29 1113.4CCKAR, CCK, GUSB
30mannitol45 1111.4CRP
31cholesterol45 29 11 2413.4CCKAR, CCK, S100A9, CRP, MUC3A, GPT
32acetylcholine45 50 29 11 2414.4CD40LG, CRP, GUSB, CCK
33glycyrrhizin45 2911.3GPT, GUSB
34atorvastatin45 50 29 11 2414.3GPT, CD40LG, CRP
35sulfate45 2411.2CCKAR, CCK, GUSB
36calcium45 50 11 2413.1CCKAR, CCK, S100A9, GUSB, CRP, MUC3A
37tirofiban45 1111.0CD40LG, CRP

GO Terms for genes affiliated with Cholecystitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.2CLDN1, CLDN2, OCLN
2extracellular spaceGO:0056159.9CCK, S100A9, CRP, F12, CXCL16, CD40LG
3extracellular regionGO:0055769.6CXCL16, MUC3A, PRSS27, F12, CRP, S100A9
4plasma membraneGO:0058869.5CXCR6, CLDN2, CXCL16, SVIP, CD40LG, OCLN

Biological processes related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.1CXCR6, CD40LG, CRP, S100A9

Molecular functions related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00519810.1KRT81, CLDN1, CLDN2, OCLN

Products for genes affiliated with Cholecystitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholecystitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet