MCID: CHL067
MIFTS: 60

Cholecystitis malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Cholecystitis

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Cholecystitis (Greek, -cholecyst, \"gallbladder\", combined with the suffix -itis, \"inflammation\") is... more...

MalaCards: Cholecystitis, also known as chronic cholecystitis, is related to emphysematous cholecystitis and cholelithiasis. An important gene associated with Cholecystitis is CCK (cholecystokinin). The compounds bromosulfophthalein and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Disease Ontology:9 A cholangitis that is an inflammation of the gallbladder.

Description from OMIM:48 600803

Aliases & Classifications for Cholecystitis

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9Disease Ontology, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 63UMLS, 48OMIM, 28ICD9CM, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholecystitis 9 44 23 11 46 63
chronic cholecystitis 9 46 63
acalculous cholecystitis 44 63
acute cholecystitis 9 46
acute cholecystitis unspecified 9
acute and chronic cholecystitis 9
acute on chronic cholecystitis 9
acute cholecystitis nos 9
gallstone cholecystitis 44
cholecystitis, acute 63


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Disease Ontology9 DOID:1949
OMIM48 600803
ICD9CM28 575.10
SNOMED-CT59 76581006, 197414008
MeSH36 D002764
NCIt41 C34465

Related Diseases for Cholecystitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to cholecystitis

Symptoms for Cholecystitis

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48OMIM
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Clinical features from OMIM:

600803

Drugs & Therapeutics for Cholecystitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cholecystitis

Drug clinical trials:

Search ClinicalTrials for Cholecystitis

Search NIH Clinical Center for Cholecystitis

Search CenterWatch for Cholecystitis

Genetic Tests for Cholecystitis

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23GTR
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Genetic tests related to Cholecystitis:

id Genetic test Affiliating Genes
1 Cholecystitis23

Anatomical Context for Cholecystitis

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34MalaCards
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MalaCards organs/tissues related to Cholecystitis:

34
Liver, B cells, Bone marrow, Bone, Testes, Spinal cord, Colon, Smooth muscle, Pancreas, Breast, Heart, Kidney, Skin, T cells, Lung

Animal Models for Cholecystitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cholecystitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0CD40LG, CCK, CXCL16, GUSB
2MP:00053767.8CD40LG, CRP, CCK, CXCL16, GUSB

Publications for Cholecystitis

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53PubMed
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Articles related to Cholecystitis:

(show top 50)    (show all 1206)
idTitleAuthorsYear
1
Xanthogranulomatous cholecystitis: a clinicopathological study of its association with gallbladder carcinoma. (23134201)
2013
2
The impact of the Japanese clinical guidelines on the clinical management of patients with acute cholecystitis. (23564194)
2013
3
A case of concomitant perforated acute cholecystitis and pancreatitis. (23956917)
2013
4
Gallbladder metastasis secondary to gastric cancer as a first site of recurrence presented with acute cholecystitis: case report and literature review. (23864451)
2012
5
Xanthogranulomatous cholecystitis: sonographic and CT features and differentiation from gallbladder carcinoma: a pictorial essay. (22488612)
2012
6
Acute cholecystitis: preoperative CT can help the surgeon consider conversion from laparoscopic to open cholecystectomy. (22332066)
2012
7
Spontaneous gallbladder perforation in acalculous hemorrhagic cholecystitis. (22273285)
2012
8
Hyalinizing cholecystitis and associated carcinomas: clinicopathologic analysis of a distinctive variant of cholecystitis with porcelain-like features and accompanying diagnostically challenging carcinomas. (21716080)
2011
9
Emphysematous cholecystitis: Imaging findings in nine patients. (21799598)
2011
10
Acute cholecystitis and bacteraemia due to Streptococcus bovis biotype II. (21195508)
2011
11
Laparoscopic ventral hernia repair with acute perforated cholecystitis and no short- or long-term evidence of prosthesis infection. (21679572)
2011
12
Rapidly onset rectus sheath hematoma mimicking cholecystitis. (21036504)
2011
13
Upper gastrointestinal bleeding related to emphysematous cholecystitis due to Clostridium perfringens. (19660973)
2010
14
Role of antibiotics in the severity of cholecystitis. (19837392)
2010
15
Trifascicular block and a raised Troponin 'T' in acute cholecystitis. (19846576)
2010
16
Acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib. (19213671)
2009
17
Transgastric endoscopic ultrasound (EUS)-guided gallbladder drainage for acute cholecystitis. (19921608)
2009
18
Is xanthogranulomatous cholecystitis the most difficult for laparoscopic cholecystectomy? (19621662)
2009
19
Percutaneous gallbladder drainage for xanthogranulomatous cholecystitis. (18936677)
2008
20
Laparoscopic cholecystectomy for severe acute cholecystitis in a patient with situs inversus totalis and posterior cystic artery. (18493329)
2008
21
Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis. (19245149)
2008
22
Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction. (17803654)
2007
23
Acalculous cholecystitis, multifocal gastrointestinal infarction and pancreatitis resulting from Varicella-zoster virus. (15667476)
2005
24
Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma. (15821928)
2005
25
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. (15447999)
2004
26
Significance of expression of epidermal growth factor (EGF) and its receptor (EGFR) in chronic cholecystitis and gallbladder carcinoma]. (12654182)
2003
27
Churg-strauss syndrome with cholecystitis and renal involvement. (14518684)
2003
28
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
29
Effect of acalculous cholecystitis on gallbladder neuromuscular transmission and contractility. (10644487)
2000
30
Altered mucin core peptide expression in acute and chronic cholecystitis. (10877217)
2000
31
Acute acalculous cholecystitis in leptospirosis. (10509958)
1999
32
Acute acalculous cholecystitis complicating oral recontamination after allogeneic bone marrow transplantation. (21590149)
1997
33
Xanthogranulomatous cholecystitis: a radiological study of 12 cases and a review of the literature. (8832871)
1996
34
Acalculous cholecystitis in children. (8632265)
1996
35
Value of laparoscopy in trauma ICU patients with suspected acute acalculous cholecystitis. (8073348)
1994
36
Acute acalculous cholecystitis in the critically ill. (8161083)
1994
37
Percutaneous transhepatic cholecystostomy for acute acalculous cholecystitis. (8252358)
1993
38
Xanthogranulomatous gastritis: association with xanthogranulomatous cholecystitis. (8432899)
1993
39
Acute emphysematous cholecystitis: a case report and review of the literature. (1407806)
1992
40
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
41
Sonography in the diagnosis and management of acute acalculous cholecystitis. (3316013)
1987
42
Percutaneous cholecystostomy in patient at high risk. Treatment of acute acalculous cholecystitis. (3809037)
1987
43
Acute acalculous cholecystitis. (3763015)
1986
44
Emphysematous cholecystitis. (3733355)
1986
45
Acute acalculous cholecystitis: sensitivity in detection using technetium-99m iminodiacetic acid cholescintigraphy. (3715046)
1986
46
Acute emphysematous cholecystitis - 2 case reports. (6576109)
1983
47
Acute-on-chronic acalculous cholecystitis in a Black child. A case report and review of the literature. (6879365)
1983
48
Postoperative acute acalculous cholecystitis--an assessment of diagnostic procedures. (7380156)
1980
49
Acute emphysematous cholecystitis. (4377171)
1974
50
Emphysematous cholecystitis; report of a case with successful treatment. (14847498)
1951

Variations for Cholecystitis

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Cholecystitis:

1
id Gene Name Type Significance SNP ID Assembly Location
1ABCB4NM_018849.2(ABCB4): c.959C> T (p.Ser320Phe)single nucleotide variantPathogenicrs72552778GRCh37Chr 7, 87076396: 87076396
2ABCB4NM_018849.2(ABCB4): c.523A> G (p.Thr175Ala)single nucleotide variantPathogenicrs58238559GRCh37Chr 7, 87082273: 87082273
3ABCB4NM_018849.2(ABCB4): c.3502C> T (p.Pro1168Ser)single nucleotide variantPathogenicrs121918442GRCh37Chr 7, 87035609: 87035609
4ABCB4NM_018849.2(ABCB4): c.1769G> A (p.Arg590Gln)single nucleotide variantPathogenicrs45575636GRCh37Chr 7, 87060844: 87060844
5ABCB4NM_018849.2(ABCB4): c.1633C> G (p.Arg545Gly)single nucleotide variantPathogenicrs397514620GRCh37Chr 7, 87069081: 87069081

Expression for genes affiliated with Cholecystitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholecystitis

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Pathways for genes affiliated with Cholecystitis

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Compounds for genes affiliated with Cholecystitis

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46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 3BitterDB, 62Tocris Bioscience
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Compounds related to Cholecystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1bromosulfophthalein469.9CCK, GPT
2omeprazole46 52 30 25 1213.8CCK, CRP
3ketamine46 30 1211.7CRP, GUSB
4glycocholate469.7GUSB, GPT
5d penicillamine469.7GPT, CRP
6glycyrrhizin46 3010.7GPT, GUSB
7ezetimibe46 1210.7GPT, CRP
8ranitidine46 30 25 1212.6CCK, CD40LG
9rosuvastatin46 52 30 1212.6CRP, GPT
10bezafibrate46 30 1211.6CRP, GPT
11gamma globulin469.5CD40LG, CRP
12silymarin469.5GPT, GUSB
13hydroxychloroquine46 1210.5CD40LG, CRP
14tirofiban46 1210.5CD40LG, CRP
15phosphorylcholine46 2510.5CD40LG, CRP
16pmma469.5CRP, CD40LG
17abciximab46 1210.5CRP, CD40LG
18okt3469.4CD40LG, CRP
19sulfasalazine30 46 52 1212.4CD40LG, CRP
20chenodeoxycholic acid46 30 25 1212.4CCK, GPT
21clopidogrel46 52 25 1212.4CRP, CD40LG
22folate469.2CRP, CCK, CD40LG
23valproate469.1GPT, CD40LG
24erythromycin46 3 52 1212.1GUSB, CD40LG
25glutamine469.1CCK, CRP, GPT
26ursodeoxycholic acid46 25 1211.1GPT, CCK, CD40LG
27norepinephrine46 25 1211.1CRP, CD40LG, CCK
28cocaine46 1210.1GPT, CCK, CD40LG
29histamine46 30 2511.1CCK, CD40LG, GUSB
30mycophenolate mofetil46 52 1211.0GPT, CD40LG
31mannitol46 1210.0GUSB, CRP, CD40LG
32fenofibrate46 52 1211.0CRP, CD40LG, GPT
33ivig468.9GPT, CRP, CD40LG
34neopterin468.9CD40LG, CRP, GPT
35pravastatin46 52 30 25 1212.9CRP, CD40LG, GPT
36atorvastatin46 52 30 25 1212.9GPT, CRP, CD40LG
37vitamin a46 25 1210.9GPT, CRP, CD40LG
38lactulose468.9CCK, GUSB, GPT, CRP
39n acetylcysteine468.9CD40LG, CRP, GPT
40fibrinogen468.9CRP, GPT, CD40LG
41cyclosporin a46 30 6210.8GPT, CD40LG, CCK
42pge2468.8CD40LG, CCK, GUSB
43aspirin46 52 30 2511.7GUSB, CRP, CD40LG, CCK
44acetylcholine46 52 30 25 1212.7CCK, CD40LG, GUSB, CRP
45glutamate468.5GPT, CD40LG, CCK, GUSB
46dopamine46 30 25 1211.5CCK, CD40LG, GUSB
47vitamin b12468.4GUSB, GPT, CD40LG, CRP
48lactate468.4CD40LG, GPT, GUSB, CRP
49creatinine468.4GPT, GUSB, CRP, CD40LG
50aspartate468.4GUSB, CRP, CD40LG, GPT

GO Terms for genes affiliated with Cholecystitis

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17Gene Ontology
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Cellular components related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.9CD40LG, KRT81, CRP, CCK, CXCL16

Products for genes affiliated with Cholecystitis

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Sources for Cholecystitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet