MCID: CHL067
MIFTS: 62

Cholecystitis malady

Gastrointestinal diseases category

Summaries for Cholecystitis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Cholecystitis (Greek, -cholecyst, \"gallbladder\", combined with the suffix -itis, \"inflammation\") is... more...

MalaCards: Cholecystitis, also known as chronic cholecystitis, is related to acalculous cholecystitis and emphysematous cholecystitis. An important gene associated with Cholecystitis is CCK (cholecystokinin), and among its related pathways are Leukocyte transendothelial migration and Cell adhesion molecules (CAMs). The compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A cholangitis that is an inflammation of the gallbladder.

Description from OMIM:46 600803

Aliases & Classifications for Cholecystitis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 46OMIM, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholecystitis 8 42 22 10 44 60
chronic cholecystitis 8 44 60
acalculous cholecystitis 42 60
acute cholecystitis 8 44
acute cholecystitis unspecified 8
acute and chronic cholecystitis 8
acute on chronic cholecystitis 8
acute cholecystitis nos 8
gallstone cholecystitis 42
cholecystitis, acute 60


External Ids:

Disease Ontology8 DOID:1949
MeSH34 D002764
NCIt39 C34465
SNOMED-CT56 197414008, 76581006
OMIM46 600803
ICD9CM27 575.10

Related Diseases for Cholecystitis

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17GeneCards, 18GeneDecks
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Diseases related to Cholecystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1acalculous cholecystitis31.7TDH
2emphysematous cholecystitis31.3KRT81
3xanthogranulomatous cholecystitis31.2S100A9
4cholelithiasis30.9GPT, GUSB, CCK
5pancreatitis30.8CRP, CCK, CCKAR
6hepatitis30.8GUSB, CD40LG, GPT
7cholangitis30.7GPT
8acute pancreatitis30.5GPT, CRP, CCK, CCKAR
9systemic lupus erythematosus30.4S100A9, GUSB, CRP, CD40LG
10choledocholithiasis30.3GPT, GUSB
11adenocarcinoma30.3CCKAR, CCK, S100A9, GUSB, MUC3A, CLDN2
12peritonitis30.2CRP
13obstructive jaundice30.1CCK, GPT
14antiphospholipid syndrome30.1CD40LG
15scrub typhus30.0CD40LG, GPT
16infectious mononucleosis30.0CD40LG, GUSB
17crohn's disease29.9CRP
18pyelonephritis29.9CRP
19duodenal ulcer29.9CCK
20hepatitis c29.9CD40LG, CXCR6, GPT
21sarcoma29.7GUSB
22nephrotic syndrome29.7GUSB
23peptic ulcer29.7CCK
24kawasaki disease29.7GPT, CRP
25cystic fibrosis29.7S100A9, GUSB, MUC3A
26gallbladder disease29.7CCKAR, CCK
27atherosclerosis29.7S100A9, CRP, CD40LG, CXCL16, CXCR6
28ulcerative colitis29.7CLDN2, MUC3A, CRP, GUSB
29respiratory failure29.7CRP, CCK
30gallbladder cancer10.5
31acute cholangitis10.4
32hepatitis a10.3
33leptospirosis10.3
34duodenitis10.3
35lupus erythematosus10.3
36appendicitis10.2
37typhoid fever10.2
38burns10.2
39q fever10.2
40gas gangrene10.2
41churg-strauss syndrome10.2
42malaria10.2
43plasmodium malariae malaria10.1
44ascariasis10.1
45sclerosing cholangitis10.1
46aortic aneurysm10.1
47gallbladder adenocarcinoma10.1
48cholera10.1
49cholecystolithiasis10.1
50portal vein thrombosis10.1

Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to cholecystitis

Clinical Features for Cholecystitis

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46OMIM
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Clinical features from OMIM:

600803

Drugs & Therapeutics for Cholecystitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholecystitis

Drug clinical trials:

Search ClinicalTrials for Cholecystitis

Search NIH Clinical Center for Cholecystitis

Search CenterWatch for Cholecystitis

Genetic Tests for Cholecystitis

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Sources:
22GTR
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Genetic tests related to Cholecystitis:

id Genetic test Affiliating Genes
1 Cholecystitis22

Anatomical Context for Cholecystitis

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32MalaCards
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MalaCards organs/tissues related to Cholecystitis:

32
Liver, B cells, Bone marrow, Bone, Testes, Spinal cord, Colon, Smooth muscle, Pancreas, Breast, Heart, Kidney, Skin, T cells, Lung

Animal Models for Cholecystitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholecystitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.6CXCL16, CCK, S100A9, GUSB, CRP, F12

Publications for Cholecystitis

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50PubMed
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Articles related to Cholecystitis:

(show top 50)    (show all 1220)
idTitleAuthorsYear
1
Acute cholecystitis from typhic origin in children. (23860057)
2013
2
Progression of Tokyo Guidelines and Japanese Guidelines for management of acute cholangitis and cholecystitis. (24334691)
2013
3
Clinical outcomes of a percutaneous cholecystostomy for acute cholecystitis: a multicentre analysis. (23750493)
2013
4
Cholecystocolonic fistula mimicking acute cholecystitis diagnosed unequivocally by computed tomography. (23722611)
2013
5
Spontaneous gallbladder perforation in acalculous hemorrhagic cholecystitis. (22273285)
2012
6
A Rare Case of Cholecystitis Caused by Raoultella planticola. (22690225)
2012
7
Cholecystitis or cholestasis after total gastrectomy and esophagectomy. (22683962)
2012
8
Acute cholecystitis with pseudoaneurysm of the cystic artery. (22880508)
2012
9
Spontaneous haemorrhagic perforation of gallbladder in acute cholecystitis as a complication of antiplatelet, immunosuppressant and corticosteroid therapy. (22778467)
2012
10
Non-operative management of acute cholecystitis in the elderly. (22829411)
2012
11
Hepatic radioembolization complicated by radiation cholecystitis. (22654269)
2011
12
Acute cholecystitis after colonoscopy: a case series. (21549374)
2011
13
Abdominal pain due to cholecystitis as first sign of septic salmonellosis in a patient with Crohn's disease on infliximab. (21472825)
2011
14
Upper gastrointestinal bleeding related to emphysematous cholecystitis due to Clostridium perfringens. (19660973)
2010
15
Sporadic TP53 transition mutations in chronic cholecystitis are possibly linked to gallbladder carcinogenesis. (21115891)
2010
16
Acute acalculous cholecystitis. (20478490)
2010
17
Is it acalculous cholecystitis or reactive/viral pericholecystits in acute hepatitis? (21340313)
2010
18
Pneumomediastinum as a complication of emphysematous cholecystitis: case report. (20813063)
2010
19
Acute acalculous cholecystitis causing gall bladder perforation in children. (21170198)
2010
20
Liver test patterns in patients with acute calculous cholecystitis and/or choledocholithiasis. (19210291)
2009
21
Portal vein gas due to gangrenous cholecystitis treated by a laparoscopic procedure: report of a case. (19784734)
2009
22
Acalculous cholecystitis in severely burned patients: incidence and predisposing factors. (18951710)
2009
23
Acute acalculous cholecystitis simulating Mirizzi syndrome: a very rare condition. (19139716)
2009
24
Endoscopic management of acute cholecystitis and cholangitis caused by limy bile. (20431775)
2009
25
An uncommon cause of right hypochondriac pain. Acute acalculous cholecystitis due to Ascaris lumbricoides with intestinal ascariasis was diagnosed. (19568568)
2009
26
Overcoming of a "surgical dogma" in acute cholecystitis treated in postponed emergency. (19967887)
2009
27
Acute acalculous cholecystitis: an unusual presenting feature of Churg-Strauss vasculitis. (19057725)
2008
28
Acute acalculous cholecystitis due to Taenia saginata. (18779634)
2008
29
Acalculous cholecystitis in a patient with Plasmodium falciparum infection: a case report and literature review. (16706951)
2006
30
Acalculous cholecystitis, multifocal gastrointestinal infarction and pancreatitis resulting from Varicella-zoster virus. (15667476)
2005
31
Percutaneous transhepatic gallbladder stenting for recurrent acute acalculous cholecystitis after failed endoscopic attempt. (16133694)
2005
32
Fitz-Hugh-Curtis-syndrome mimicking acute cholecystitis: value of new ultrasound findings in the differential diagnosis. (15948060)
2005
33
Plain abdominal radiography: a diagnostic aid in emphysematous cholecystitis. (15055920)
2004
34
CT and MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. (12904879)
2004
35
Acute emphysematous cholecystitis. (11374650)
2001
36
Xanthogranulomatous cholecystitis: a complication of metallic biliary stent placement. (8682448)
1996
37
Chronic acalculous cholecystitis: laparoscopic treatment. (8680633)
1996
38
Emphysematous cholecystitis after endoscopic wallstent placement complicated by distal migration of the stent. (8903988)
1995
39
Xanthogranulomatous cholecystitis. (7599763)
1995
40
Acute acalculous cholecystitis in an infant after cardiac surgery. (7877035)
1994
41
Acute acalculous cholecystitis in infective endocarditis. (8229552)
1993
42
Acute acalculous cholecystitis in a young child. (2286444)
1990
43
Allergic granulomatosis and angiitis (Churg-Strauss syndrome) presenting as acute acalculous cholecystitis. (2319525)
1990
44
Radiology and pathology in canine acalculous cholecystitis. (3054327)
1988
45
Cholecystitis and bronchopneumonia associated with Pseudomonas aeruginosa in a koala. (3099739)
1986
46
Gas in the bile ducts (pneumobilia) in emphysematous cholecystitis. (102158)
1978
47
Cholecystokinin cholecystography in the diagnosis of chronic acalculous cholecystitis and biliary dyskinesia. A cirtical appraisal. (615784)
1977
48
Acute emphysematous cholecystitis. (5089624)
1971
49
Acute cholecystitis as a sequel of scarlet fever. (5550740)
1971
50
Cholecystitis due to granular cell myoblastoma of the cystic duct. (14445086)
1960

Genetic Variations for Cholecystitis

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Expression for genes affiliated with Cholecystitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for genes affiliated with Cholecystitis

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29KEGG, 51QIAGEN
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Pathways related to Cholecystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CLDN1, CLDN2, OCLN
210.1CLDN1, CLDN2, CD40LG, OCLN
3
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10.1OCLN, CLDN2, CLDN1, CXCL16, CXCR6

Compounds for genes affiliated with Cholecystitis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Cholecystitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4410.7CCK, CCKAR
2asperlicin4410.7CCKAR, CCK
3lorglumide44 2811.7CCKAR, CCK
4l3652604410.7CCK, CCKAR
5ym0224410.7CCKAR, CCK
6dexloxiglumide44 2811.7CCKAR, CCK
7devazepide44 28 5912.7CCKAR, CCK
8caerulein4410.7CCKAR, CCK
9bromosulfophthalein4410.6GPT, CCK
10omeprazole44 28 49 11 2414.6CCKAR, CCK, CRP
11loxiglumide4410.6CCK, CCKAR
12ursodeoxycholic acid44 11 2412.6GPT, CD40LG, CCK
13lactulose4410.6CCK, GUSB, CRP, GPT
14vitamin b124410.6GUSB, CD40LG, GPT, CRP
15gamma globulin4410.6CD40LG, CRP
16fenofibrate44 49 1112.6CRP, GPT, CD40LG
17benzodiazepines4410.6CCK, CCKAR
18cocaine44 1111.6CD40LG, CCK, GPT, CCKAR
19erythromycin44 49 2 1113.6CD40LG, GUSB, CCKAR
20ivig4410.6GPT, CD40LG, CRP
21glycocholate4410.6GPT, GUSB
22aspirin44 49 28 2413.5F12, CRP, GUSB, CCK, CD40LG
23neopterin4410.5CD40LG, GPT, CRP
24hydroxychloroquine44 1111.5CD40LG, CRP
25pravastatin44 49 28 11 2414.5CD40LG, CRP, GPT
26fibrinogen4410.5CRP, CD40LG, S100A9, F12, GPT
27methotrexate44 49 1112.5GPT, MUC3A, CRP, S100A9
28d penicillamine4410.4CRP, GPT
29morphine44 49 28 1113.4CCKAR, CCK, GUSB
30mannitol44 1111.4CRP
31cholesterol44 28 11 2413.4CRP, CCKAR, S100A9, GPT, MUC3A, CCK
32acetylcholine44 49 28 11 2414.4GUSB, CCK, CRP, CD40LG
33tirofiban44 1111.3CD40LG, CRP
34atorvastatin44 49 28 11 2414.3GPT, CD40LG, CRP
35sulfate44 2411.2CCKAR, GUSB, CCK
36calcium44 49 11 2413.1CRP, CCKAR, CXCR6, CXCL16, CLDN1, CLDN2
37glycyrrhizin44 2811.0GPT, GUSB

GO Terms for genes affiliated with Cholecystitis

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16Gene Ontology
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Cellular components related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.2CLDN1, CLDN2, OCLN
2extracellular spaceGO:0056159.9CCK, S100A9, CRP, F12, CXCL16, CD40LG
3extracellular regionGO:0055769.6CXCL16, MUC3A, PRSS27, F12, CRP, S100A9
4plasma membraneGO:0058869.5CXCR6, CLDN2, CXCL16, SVIP, CD40LG, OCLN

Biological processes related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.1CXCR6, CD40LG, CRP, S100A9

Molecular functions related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00519810.1KRT81, CLDN1, CLDN2, OCLN

Products for genes affiliated with Cholecystitis

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Sources for Cholecystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet