MCID: CHL067
MIFTS: 60

Cholecystitis malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Cholecystitis

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Cholecystitis (Greek, -cholecyst, \"gallbladder\", combined with the suffix -itis, \"inflammation\") is... more...

MalaCards: Cholecystitis, also known as chronic cholecystitis, is related to emphysematous cholecystitis and cholelithiasis. An important gene associated with Cholecystitis is CCK (cholecystokinin). The compounds bromosulfophthalein and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Disease Ontology:8 A cholangitis that is an inflammation of the gallbladder.

Description from OMIM:47 600803

Aliases & Classifications for Cholecystitis

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8Disease Ontology, 43NIH Rare Diseases, 22GTR, 10DISEASES, 45Novoseek, 62UMLS, 47OMIM, 27ICD9CM, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholecystitis 8 43 22 10 45 62
chronic cholecystitis 8 45 62
acalculous cholecystitis 43 62
acute cholecystitis 8 45
acute cholecystitis unspecified 8
acute and chronic cholecystitis 8
acute on chronic cholecystitis 8
acute cholecystitis nos 8
gallstone cholecystitis 43
cholecystitis, acute 62


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Disease Ontology8 DOID:1949
OMIM47 600803
ICD9CM27 575.10
SNOMED-CT58 76581006, 197414008
MeSH35 D002764
NCIt40 C34465

Related Diseases for Cholecystitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to cholecystitis

Symptoms for Cholecystitis

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47OMIM
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Clinical features from OMIM:

600803

Drugs & Therapeutics for Cholecystitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cholecystitis

Search NIH Clinical Center for Cholecystitis

Genetic Tests for Cholecystitis

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22GTR
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Genetic tests related to Cholecystitis:

id Genetic test Affiliating Genes
1 Cholecystitis22

Anatomical Context for Cholecystitis

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33MalaCards
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MalaCards organs/tissues related to Cholecystitis:

33
Liver, B cells, Bone marrow, Bone, Testes, Spinal cord, Colon, Smooth muscle, Pancreas, Breast, Heart, Kidney, Skin, T cells, Lung

Animal Models for Cholecystitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cholecystitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0CD40LG, CCK, CXCL16, GUSB
2MP:00053767.8CD40LG, CRP, CCK, CXCL16, GUSB

Publications for Cholecystitis

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52PubMed
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Articles related to Cholecystitis:

(show top 50)    (show all 1206)
idTitleAuthorsYear
1
Xanthogranulomatous cholecystitis: a clinicopathological study of its association with gallbladder carcinoma. (23134201)
2013
2
The impact of the Japanese clinical guidelines on the clinical management of patients with acute cholecystitis. (23564194)
2013
3
A case of concomitant perforated acute cholecystitis and pancreatitis. (23956917)
2013
4
Gallbladder metastasis secondary to gastric cancer as a first site of recurrence presented with acute cholecystitis: case report and literature review. (23864451)
2012
5
Xanthogranulomatous cholecystitis: sonographic and CT features and differentiation from gallbladder carcinoma: a pictorial essay. (22488612)
2012
6
Acute cholecystitis: preoperative CT can help the surgeon consider conversion from laparoscopic to open cholecystectomy. (22332066)
2012
7
Spontaneous gallbladder perforation in acalculous hemorrhagic cholecystitis. (22273285)
2012
8
Hyalinizing cholecystitis and associated carcinomas: clinicopathologic analysis of a distinctive variant of cholecystitis with porcelain-like features and accompanying diagnostically challenging carcinomas. (21716080)
2011
9
Emphysematous cholecystitis: Imaging findings in nine patients. (21799598)
2011
10
Acute cholecystitis and bacteraemia due to Streptococcus bovis biotype II. (21195508)
2011
11
Laparoscopic ventral hernia repair with acute perforated cholecystitis and no short- or long-term evidence of prosthesis infection. (21679572)
2011
12
Rapidly onset rectus sheath hematoma mimicking cholecystitis. (21036504)
2011
13
Upper gastrointestinal bleeding related to emphysematous cholecystitis due to Clostridium perfringens. (19660973)
2010
14
Role of antibiotics in the severity of cholecystitis. (19837392)
2010
15
Trifascicular block and a raised Troponin 'T' in acute cholecystitis. (19846576)
2010
16
Acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib. (19213671)
2009
17
Transgastric endoscopic ultrasound (EUS)-guided gallbladder drainage for acute cholecystitis. (19921608)
2009
18
Is xanthogranulomatous cholecystitis the most difficult for laparoscopic cholecystectomy? (19621662)
2009
19
Percutaneous gallbladder drainage for xanthogranulomatous cholecystitis. (18936677)
2008
20
Laparoscopic cholecystectomy for severe acute cholecystitis in a patient with situs inversus totalis and posterior cystic artery. (18493329)
2008
21
Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis. (19245149)
2008
22
Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction. (17803654)
2007
23
Acalculous cholecystitis, multifocal gastrointestinal infarction and pancreatitis resulting from Varicella-zoster virus. (15667476)
2005
24
Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma. (15821928)
2005
25
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. (15447999)
2004
26
Significance of expression of epidermal growth factor (EGF) and its receptor (EGFR) in chronic cholecystitis and gallbladder carcinoma]. (12654182)
2003
27
Churg-strauss syndrome with cholecystitis and renal involvement. (14518684)
2003
28
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
29
Effect of acalculous cholecystitis on gallbladder neuromuscular transmission and contractility. (10644487)
2000
30
Altered mucin core peptide expression in acute and chronic cholecystitis. (10877217)
2000
31
Acute acalculous cholecystitis in leptospirosis. (10509958)
1999
32
Acute acalculous cholecystitis complicating oral recontamination after allogeneic bone marrow transplantation. (21590149)
1997
33
Xanthogranulomatous cholecystitis: a radiological study of 12 cases and a review of the literature. (8832871)
1996
34
Acalculous cholecystitis in children. (8632265)
1996
35
Value of laparoscopy in trauma ICU patients with suspected acute acalculous cholecystitis. (8073348)
1994
36
Acute acalculous cholecystitis in the critically ill. (8161083)
1994
37
Percutaneous transhepatic cholecystostomy for acute acalculous cholecystitis. (8252358)
1993
38
Xanthogranulomatous gastritis: association with xanthogranulomatous cholecystitis. (8432899)
1993
39
Acute emphysematous cholecystitis: a case report and review of the literature. (1407806)
1992
40
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
41
Sonography in the diagnosis and management of acute acalculous cholecystitis. (3316013)
1987
42
Percutaneous cholecystostomy in patient at high risk. Treatment of acute acalculous cholecystitis. (3809037)
1987
43
Acute acalculous cholecystitis. (3763015)
1986
44
Emphysematous cholecystitis. (3733355)
1986
45
Acute acalculous cholecystitis: sensitivity in detection using technetium-99m iminodiacetic acid cholescintigraphy. (3715046)
1986
46
Acute emphysematous cholecystitis - 2 case reports. (6576109)
1983
47
Acute-on-chronic acalculous cholecystitis in a Black child. A case report and review of the literature. (6879365)
1983
48
Postoperative acute acalculous cholecystitis--an assessment of diagnostic procedures. (7380156)
1980
49
Acute emphysematous cholecystitis. (4377171)
1974
50
Emphysematous cholecystitis; report of a case with successful treatment. (14847498)
1951

Variations for Cholecystitis

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Cholecystitis:

1
id Gene Name Type Significance SNP ID Assembly Location
1ABCB4NM_018849.2(ABCB4): c.959C> T (p.Ser320Phe)single nucleotide variantPathogenicrs72552778GRCh37Chr 7, 87076396: 87076396
2ABCB4NM_018849.2(ABCB4): c.523A> G (p.Thr175Ala)single nucleotide variantPathogenicrs58238559GRCh37Chr 7, 87082273: 87082273
3ABCB4NM_018849.2(ABCB4): c.3502C> T (p.Pro1168Ser)single nucleotide variantPathogenicrs121918442GRCh37Chr 7, 87035609: 87035609
4ABCB4NM_018849.2(ABCB4): c.1769G> A (p.Arg590Gln)single nucleotide variantPathogenicrs45575636GRCh37Chr 7, 87060844: 87060844
5ABCB4NM_018849.2(ABCB4): c.1633C> G (p.Arg545Gly)single nucleotide variantPathogenicrs397514620GRCh37Chr 7, 87069081: 87069081

Expression for genes affiliated with Cholecystitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for genes affiliated with Cholecystitis

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Compounds for genes affiliated with Cholecystitis

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45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 3BitterDB, 61Tocris Bioscience
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Compounds related to Cholecystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1bromosulfophthalein459.9CCK, GPT
2omeprazole45 51 29 24 1113.8CCK, CRP
3ketamine45 29 1111.7CRP, GUSB
4glycocholate459.7GUSB, GPT
5d penicillamine459.7GPT, CRP
6glycyrrhizin45 2910.7GPT, GUSB
7ezetimibe45 1110.7GPT, CRP
8ranitidine45 29 24 1112.6CCK, CD40LG
9rosuvastatin45 51 29 1112.6CRP, GPT
10bezafibrate45 29 1111.6CRP, GPT
11gamma globulin459.5CD40LG, CRP
12silymarin459.5GPT, GUSB
13hydroxychloroquine45 1110.5CD40LG, CRP
14tirofiban45 1110.5CD40LG, CRP
15phosphorylcholine45 2410.5CD40LG, CRP
16pmma459.5CRP, CD40LG
17abciximab45 1110.5CRP, CD40LG
18okt3459.4CD40LG, CRP
19sulfasalazine29 45 51 1112.4CD40LG, CRP
20chenodeoxycholic acid45 29 24 1112.4CCK, GPT
21clopidogrel45 51 24 1112.4CRP, CD40LG
22folate459.2CRP, CCK, CD40LG
23valproate459.1GPT, CD40LG
24erythromycin45 3 51 1112.1GUSB, CD40LG
25glutamine459.1CCK, CRP, GPT
26ursodeoxycholic acid45 24 1111.1GPT, CCK, CD40LG
27norepinephrine45 24 1111.1CRP, CD40LG, CCK
28cocaine45 1110.1GPT, CCK, CD40LG
29histamine45 29 2411.1CCK, CD40LG, GUSB
30mycophenolate mofetil45 51 1111.0GPT, CD40LG
31mannitol45 1110.0GUSB, CRP, CD40LG
32fenofibrate45 51 1111.0CRP, CD40LG, GPT
33ivig458.9GPT, CRP, CD40LG
34neopterin458.9CD40LG, CRP, GPT
35pravastatin45 51 29 24 1112.9CRP, CD40LG, GPT
36atorvastatin45 51 29 24 1112.9GPT, CRP, CD40LG
37vitamin a45 24 1110.9GPT, CRP, CD40LG
38lactulose458.9CCK, GUSB, GPT, CRP
39n acetylcysteine458.9CD40LG, CRP, GPT
40fibrinogen458.9CRP, GPT, CD40LG
41cyclosporin a45 29 6110.8GPT, CD40LG, CCK
42pge2458.8CD40LG, CCK, GUSB
43aspirin45 51 29 2411.7GUSB, CRP, CD40LG, CCK
44acetylcholine45 51 29 24 1112.7CCK, CD40LG, GUSB, CRP
45glutamate458.5GPT, CD40LG, CCK, GUSB
46dopamine45 29 24 1111.5CCK, CD40LG, GUSB
47vitamin b12458.4GUSB, GPT, CD40LG, CRP
48lactate458.4CD40LG, GPT, GUSB, CRP
49creatinine458.4GPT, GUSB, CRP, CD40LG
50aspartate458.4GUSB, CRP, CD40LG, GPT

GO Terms for genes affiliated with Cholecystitis

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16Gene Ontology
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Cellular components related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.9CD40LG, KRT81, CRP, CCK, CXCL16

Products for genes affiliated with Cholecystitis

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Sources for Cholecystitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet