MCID: CHL067
MIFTS: 62

Cholecystitis malady

Gastrointestinal diseases category

Summaries for Cholecystitis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Cholecystitis (Greek, -cholecyst, \"gallbladder\", combined with the suffix -itis, \"inflammation\") is... more...

MalaCards: Cholecystitis, also known as chronic cholecystitis, is related to acalculous cholecystitis and emphysematous cholecystitis. An important gene associated with Cholecystitis is CCK (cholecystokinin), and among its related pathways are Leukocyte transendothelial migration and Cell adhesion molecules (CAMs). The compounds asperlicin and 1,4-benzodiazepine have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A cholangitis that is an inflammation of the gallbladder.

Description from OMIM:46 600803

Aliases & Classifications for Cholecystitis

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42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 34MeSH, 39NCIt, 46OMIM, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholecystitis 8 42 22 10 44 60
chronic cholecystitis 8 44 60
acalculous cholecystitis 42 60
acute cholecystitis 8 44
acute and chronic cholecystitis 8
acute cholecystitis unspecified 8
acute on chronic cholecystitis 8
gallstone cholecystitis 42
acute cholecystitis nos 8
cholecystitis, acute 60


External Ids:

Disease Ontology8 DOID:1949
MeSH34 D002764
NCIt39 C34465
SNOMED-CT56 197414008, 76581006
OMIM46 600803
ICD9CM27 575.10

Related Diseases for Cholecystitis

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17GeneCards, 18GeneDecks
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Diseases related to Cholecystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1acalculous cholecystitis31.7TDH
2emphysematous cholecystitis31.3KRT81
3xanthogranulomatous cholecystitis31.2S100A9
4cholelithiasis30.9GPT, GUSB, CCK
5pancreatitis30.8CRP, CCK, CCKAR
6hepatitis30.8GUSB, CD40LG, GPT
7cholangitis30.7GPT
8acute pancreatitis30.5GPT, CRP, CCK, CCKAR
9systemic lupus erythematosus30.4S100A9, GUSB, CRP, CD40LG
10choledocholithiasis30.3GPT, GUSB
11adenocarcinoma30.3CCKAR, CCK, S100A9, GUSB, MUC3A, CLDN2
12peritonitis30.2CRP
13obstructive jaundice30.1CCK, GPT
14antiphospholipid syndrome30.1CD40LG
15scrub typhus30.0CD40LG, GPT
16infectious mononucleosis30.0CD40LG, GUSB
17crohn's disease29.9CRP
18pyelonephritis29.9CRP
19duodenal ulcer29.9CCK
20hepatitis c29.9CD40LG, CXCR6, GPT
21sarcoma29.7GUSB
22nephrotic syndrome29.7GUSB
23peptic ulcer29.7CCK
24kawasaki disease29.7GPT, CRP
25cystic fibrosis29.7S100A9, GUSB, MUC3A
26gallbladder disease29.7CCKAR, CCK
27atherosclerosis29.7S100A9, CRP, CD40LG, CXCL16, CXCR6
28ulcerative colitis29.7CLDN2, MUC3A, CRP, GUSB
29respiratory failure29.7CRP, CCK
30gallbladder cancer10.5
31acute cholangitis10.4
32hepatitis a10.3
33leptospirosis10.3
34duodenitis10.3
35lupus erythematosus10.3
36appendicitis10.2
37typhoid fever10.2
38burns10.2
39q fever10.2
40gas gangrene10.2
41churg-strauss syndrome10.2
42malaria10.2
43plasmodium malariae malaria10.1
44ascariasis10.1
45sclerosing cholangitis10.1
46aortic aneurysm10.1
47gallbladder adenocarcinoma10.1
48cholera10.1
49cholecystolithiasis10.1
50portal vein thrombosis10.1

Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to cholecystitis

Clinical Features for Cholecystitis

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46OMIM
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Clinical features from OMIM:

600803

Drugs & Therapeutics for Cholecystitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholecystitis

Drug clinical trials:

Search ClinicalTrials for Cholecystitis

Search NIH Clinical Center for Cholecystitis

Search CenterWatch for Cholecystitis

Genetic Tests for Cholecystitis

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22GTR
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Genetic tests related to Cholecystitis:

id Genetic test Affiliating Genes
1 Cholecystitis22

Anatomical Context for Cholecystitis

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32MalaCards
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MalaCards organs/tissues related to Cholecystitis:

32
Liver, B cells, Bone marrow, Bone, Testes, Spinal cord, Colon, Smooth muscle, Pancreas, Breast, Heart, Kidney, Skin, T cells, Lung

Animal Models for Cholecystitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholecystitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.6CXCL16, CCK, S100A9, GUSB, CRP, F12

Publications for Cholecystitis

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50PubMed
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Articles related to Cholecystitis:

(show top 50)    (show all 1220)
idTitleAuthorsYear
1
Hepatobiliary rim sign: new implications for acute and complicated cholecystitis. (23470462)
2013
2
Sensitivity and predictive value of ultrasound in pediatric cholecystitis. (23664536)
2013
3
Acute Gangrenous Cholecystitis Diagnosed on Gallium Scan. (23877518)
2013
4
Usefulness of the tensile gallbladder fundus sign in the diagnosis of early acute cholecystitis. (23883214)
2013
5
Single-incision vs three-incision laparoscopic cholecystectomy for complicated and uncomplicated acute cholecystitis. (24282363)
2013
6
Acute acalculous cholecystitis in malaria: a review of seven cases from an adult cohort. (23546998)
2013
7
Use of the SAND balloon catheter in single-incision laparoscopic cholecystectomy for acute cholecystitis. (23601999)
2013
8
Cholecystoduodenal drainage and gallstone removal in a patient with cholecystitis and unresectable cholangiocarcinoma. (23716085)
2013
9
Minimally invasive surgical management of acute cholecystitis during pregnancy: what are the recommendations? (23815992)
2013
10
Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304). (24022431)
2013
11
Operative timing of laparoscopic cholecystectomy for acute cholecystitis in a Japanese institute. (22906333)
2012
12
Uncomplicated acute cholecystitis: early or delayed laparoscopic cholecystectomy? (23174798)
2012
13
Admission variables predictive of gangrenous cholecystitis. (23025944)
2012
14
A case of severe acalculous cholecystitis associated with sorafenib treatment for advanced hepatocellular carcinoma. (22645635)
2012
15
Can percutaneous cholecystostomy be a definitive management for acute acalculous cholecystitis? (21814147)
2012
16
Long-term follow-up of a randomized controlled trial of observation versus surgery for acute cholecystitis: non-operative management is an option in some patients. (21736531)
2011
17
Are liver function tests, pancreatitis and cholecystitis predictors of common bile duct stones? Results of a prospective, population-based, cohort study of 1171 patients undergoing cholecystectomy. (21762294)
2011
18
Acalculous cholecystitis and tamponade: an unusual combination? (21744712)
2011
19
Predictive factors for successful early laparoscopic cholecystectomy in acute cholecystitis: a prospective study. (20674811)
2010
20
Cholecystitis, pancreatitis and hemobilia: a serious trilogy after liver biopsy. (20958869)
2010
21
Distinguishing xanthogranulomatous cholecystitis from the wall-thickening type of early-stage gallbladder cancer. (21253302)
2010
22
Epstein Barr virus-associated acute acalculous cholecystitis: a rare occurrence but favorable outcome. (20356920)
2010
23
Transcylindrical gas-free cholecystectomy for the treatment of cholelithiasis, cholecystitis, and choledocholithiasis. (20354871)
2010
24
Is xanthogranulomatous cholecystitis the most difficult for laparoscopic cholecystectomy? (19621662)
2009
25
Cholelithiasis and cholecystitis. (19726705)
2009
26
Acute acalculous cholecystitis after trauma: the role of microcirculatory failure and cellular hypoxia. (19088512)
2008
27
Acalculous cholecystitis: an unusual presentation of acute Q fever masquerading as infectious endocarditis. (18854682)
2008
28
A 70 year old male with abdominal pain. Emphysematous cholecystitis. (19858637)
2007
29
Acute acalculous cholecystitis: challenging the myths. (18333128)
2007
30
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
31
Acute acalculous cholecystitis associated with aortic dissection: report of a case. (12884105)
2003
32
Emphysematous cholecystitis. (12768870)
2003
33
Acute acalculous cholecystitis in children: Diagnosis and treatment. (11781983)
2002
34
Ultrasound is not a useful screening tool for acute acalculous cholecystitis in critically ill trauma patients. (12467321)
2002
35
Index of suspicion. Case 1. Diagnosis: chronic acalculous cholecystitis. (9849073)
1998
36
Cholelithiasis, cholecystitis, and common bile duct stones. (9229169)
1997
37
Percutaneous cholecystostomy for the diagnosis and treatment of acute calculous and acalculous cholecystitis. (7579876)
1995
38
Acute acalculous cholecystitis in typhoid fever. (8617569)
1995
39
Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy. (8586153)
1995
40
Massive hemobilia and acalculous cholecystitis due to benign gallbladder polyp. (8508713)
1993
41
Acute acalculous cholecystitis complicating Mycoplasma pneumoniae infection. (1628474)
1992
42
Acute acalculous cholecystitis caused by Salmonella typhi in a 6-year-old child. (1420077)
1992
43
Hemorrhagic acalculous cholecystitis in systemic lupus erythematosus. (2929572)
1989
44
Emphysematous cholecystitis. (3177167)
1988
45
Acute acalculous cholecystitis caused by Salmonella typhi in an 11-year-old. (3344171)
1988
46
Percutaneous cholecystostomy in patient at high risk. Treatment of acute acalculous cholecystitis. (3809037)
1987
47
Acute acalculous cholecystitis following multiple skeletal trauma. A report of three cases. (3882018)
1985
48
Post-traumatic acalculous cholecystitis on a neurosurgical service. (6828228)
1983
49
Xanthogranulomatous cholecystitis: report of seven cases. (7258841)
1981
50
Emphysematous cholecystitis in diabetic patients. (5897372)
1965

Genetic Variations for Cholecystitis

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Expression for genes affiliated with Cholecystitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for genes affiliated with Cholecystitis

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29KEGG, 51QIAGEN
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Pathways related to Cholecystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CLDN1, CLDN2, OCLN
210.1CLDN1, CLDN2, CD40LG, OCLN
3
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10.1OCLN, CLDN2, CLDN1, CXCL16, CXCR6

Compounds for genes affiliated with Cholecystitis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Cholecystitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1asperlicin4410.7CCKAR, CCK
21,4-benzodiazepine4410.7CCKAR, CCK
3lorglumide44 2811.7CCKAR, CCK
4l3652604410.7CCKAR, CCK
5ym0224410.7CCKAR, CCK
6dexloxiglumide44 2811.7CCKAR, CCK
7devazepide44 28 5912.7CCK, CCKAR
8caerulein4410.7CCK, CCKAR
9omeprazole44 28 49 11 2414.6CCKAR, CCK, CRP
10loxiglumide4410.6CCKAR, CCK
11bromosulfophthalein4410.6CCK, GPT
12ursodeoxycholic acid44 11 2412.6CCK, CD40LG, GPT
13lactulose4410.6GPT, CRP, GUSB, CCK
14benzodiazepines4410.6CCKAR, CCK
15vitamin b124410.6GUSB, CRP, CD40LG, GPT
16fenofibrate44 49 1112.6CRP, CD40LG, GPT
17cocaine44 1111.6CCKAR, CCK, CD40LG, GPT
18ivig4410.6CRP, CD40LG, GPT
19gamma globulin4410.6CRP, CD40LG
20erythromycin44 49 2 1113.6CCKAR, GUSB, CD40LG
21glycocholate4410.6GPT, GUSB
22aspirin44 49 28 2413.5CCK, GUSB, CRP, F12, CD40LG
23neopterin4410.5GPT, CD40LG, CRP
24hydroxychloroquine44 1111.5CRP, CD40LG
25pravastatin44 49 28 11 2414.5GPT, CD40LG, CRP
26fibrinogen4410.5S100A9, CRP, F12, CD40LG, GPT
27methotrexate44 49 1112.5GPT, MUC3A, CRP, S100A9
28d penicillamine4410.4GPT, CRP
29morphine44 49 28 1113.4CCKAR, CCK, GUSB
30mannitol44 1111.4CRP
31cholesterol44 28 11 2413.4CCKAR, CCK, S100A9, CRP, MUC3A, GPT
32acetylcholine44 49 28 11 2414.4CD40LG, CRP, GUSB, CCK
33glycyrrhizin44 2811.3GPT, GUSB
34atorvastatin44 49 28 11 2414.3GPT, CD40LG, CRP
35sulfate44 2411.2CCKAR, CCK, GUSB
36calcium44 49 11 2413.1CCKAR, CCK, S100A9, GUSB, CRP, MUC3A
37tirofiban44 1111.0CD40LG, CRP

GO Terms for genes affiliated with Cholecystitis

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16Gene Ontology
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Cellular components related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.2CLDN1, CLDN2, OCLN
2extracellular spaceGO:0056159.9CCK, S100A9, CRP, F12, CD40LG, CXCL16
3extracellular regionGO:0055769.6CCK, S100A9, CRP, F12, PRSS27, MUC3A
4plasma membraneGO:0058869.5CXCR6, CCKAR, S100A9, CRP, F12, PRSS27

Biological processes related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.1CXCR6, CD40LG, CRP, S100A9

Molecular functions related to Cholecystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00519810.1KRT81, CLDN1, CLDN2, OCLN

Products for genes affiliated with Cholecystitis

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Sources for Cholecystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet