MCID: CHL052
MIFTS: 43

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Choledochal Cyst

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Wikipedia:63 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards based summary: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and acute pancreatitis. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds taurodeoxycholate and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are muscle and nervous system.

Aliases & Classifications for Choledochal Cyst

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Choledochal Cyst, Aliases & Descriptions:

Name: Choledochal Cyst 9
Cystic Dilatation of Common Bile Duct 60
 
Congenital Choledochal Cyst 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology9 DOID:899
MeSH33 D015529
SNOMED-CT55 30533003, 398197009
NCIt38 C2943
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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Diseases related to Choledochal Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.6SCT, REG1A, SST
2acute pancreatitis31.0SST, REG1A, SCT
3cholangiocarcinoma30.8PTGS2, SCT
4neuroendocrine tumor30.6SCT, SST
5adenoma30.1SCT, PTGS2, REG1A, SST
6pancreatic cancer29.8SCT, PTGS2, REG1A, SST
7adenocarcinoma29.7SCT, PTGS2, VIM, REG1A, SST, NOS2
8biliary atresia10.8
9hepatitis10.7
10duodenitis10.5
11infantile myofibromatosis10.5DES
12rhabdomyosarcoma10.5
13angiodysplasia10.5SST
14dumping syndrome10.5SST
15obstructive jaundice10.5
16biliary papillomatosis10.5
17portal hypertension10.4
18duodenal atresia10.4
19collagenous colitis10.4NOS2
20adenomatoid tumor10.4VIM
21cystadenoma10.3
22cholelithiasis10.3
23cholangitis10.3
24intrahepatic cholangiocarcinoma10.3
25peritonitis10.3
26bile duct cysts10.3
27chylous ascites10.3
28colonic atresia10.3
29hyperinsulinemic hypoglycemia, familial, 210.3SST, SCT
30vipoma10.3SCT, SST
31zollinger-ellison syndrome10.3SCT, SST
32steatorrhea10.3SCT, SST
33pancreas disease10.3REG1A, SCT
34atrophic gastritis10.3SCT, SST
35glucagonoma10.3SCT, SST
36duodenal ulcer10.3SST, SCT
37gastrinoma10.3SCT, SST
38lymphangitis10.3
39cholecystitis10.3
40duodenal obstruction10.3
41embryonal rhabdomyosarcoma10.3
42gastritis10.3SCT, NOS2
43multiple endocrine neoplasia 110.3SST, SCT
44lymphangioleiomyomatosis10.3DES, MMP1
45fibromatosis10.2VIM, DES
46epithelioid leiomyosarcoma10.2VIM, DES
47mesenchymal chondrosarcoma10.2VIM, DES
48pseudosarcomatous fibromatosis10.2DES, VIM
49spindle cell carcinoma10.2VIM, DES
50spindle cell sarcoma10.2DES, VIM

Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Symptoms for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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Drug clinical trials:

Search ClinicalTrials for Choledochal Cyst

Search NIH Clinical Center for Choledochal Cyst

Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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MalaCards organs/tissues related to Choledochal Cyst:

31
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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MGI Mouse Phenotypes related to Choledochal Cyst:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0DES, PTGS2, VIM, NOS2
2MP:00036317.8NOS2, SST, VIM, PTGS2, SCT
3MP:00053867.4DES, SCT, PTGS2, VIM, SST, NOS2
4MP:00053877.3PTGS2, VIM, MMP1, SST, NOS2
5MP:00053766.5NOS2, DES, SCT, PTGS2, VIM, MMP1

Publications for Choledochal Cyst

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Articles related to Choledochal Cyst:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Clinical value of ultrasound in diagnosing pediatric choledochal cyst perforation. (25714296)
2015
2
Coagulopathy in a subtype of choledochal cyst and management strategy. (25132782)
2014
3
Conservative management of a choledochal cyst during a twin pregnancy. (25546522)
2014
4
Choledochal cyst - a different disease in newborns and infants. (25404451)
2014
5
Mid-term Outcomes of Laparoscopic Versus Open Choledochal Cyst Excision in a Tertiary Paediatric Hospital. (24833074)
2014
6
Laparoscopic resection of choledochal cyst: report of a case. (23657070)
2013
7
Early experience of laparoscopic choledochal cyst excision in children. (24266013)
2013
8
Intact Choledochal Cyst with Spontaneous Common Hepatic Duct Perforation: A Spectrum of Congenital Biliary Canal Defects? (23343939)
2013
9
Unexpected small bowel polyposis in a man with a choledochal cyst, more than a difficult cannulation. (22906397)
2012
10
Choledochal cyst: presentation of the disease with a case report. (21875424)
2011
11
The effect of laparoscopic excision vs open excision in children with choledochal cyst: a midterm follow-up study. (21496534)
2011
12
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
13
Type IV A choledochal cyst with cystic duct cyst. (20590899)
2010
14
Adult type I choledochal cyst resection. (18446417)
2009
15
Choledochal cyst associated with duodenal atresia: case report and review of the literature. (19693517)
2009
16
Choledochal cyst during pregnancy: the patient's first pregnancy was complicated by a congenital anomaly. (19375577)
2009
17
Choledochal cyst as a diagnostic pitfall: a case report. (18194562)
2008
18
Fetal choledochal cyst diagnosed at 22 weeks of gestation by three-dimensional ultrasonography: a case report. (18955804)
2008
19
An adult choledochal cyst--the magnetic resonance cholangiopancreatography findings: report of a case. (18958568)
2008
20
Image of the month. Choledochal cyst, Todani type I. (17938316)
2007
21
Aplasia of the dorsal pancreas and choledochal cyst. (16474976)
2006
22
Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children. (16707978)
2006
23
Type IV-a choledochal cyst--a rare adolescent presentation as acute abdomen. (16909261)
2006
24
Spontaneous rupture of a type IVA choledochal cyst in a young adult during radiological imaging. (16521234)
2006
25
Pancreatitis complicated with dilated choledochal remnant after congenital choledochal cyst excision. (16195912)
2005
26
Traumatic rupture of choledochal cyst in a child. (15750916)
2005
27
Embryonal rhabdomyosarcoma of the common bile duct mimicking choledochal cyst. (15995817)
2005
28
A retrospective study of choledochal cyst: clinical presentation, diagnosis and treatment. (14768797)
2003
29
Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children. (14666479)
2003
30
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. (11290894)
2001
31
Massive dilatation of the common bile duct resembling a choledochal cyst. (11963332)
2001
32
Anomalous pancreaticobiliary junction without congenital choledochal cyst. (10419333)
1999
33
Choledochal cyst associated with polycystic kidney disease: report of a case. (10371064)
1999
34
Choledochal cyst in Simpson-Golabi-Behmel syndrome. (10564884)
1999
35
Choledochal cyst: review of 74 pediatric cases. (9737111)
1998
36
Choledochal cyst with or without biliary atresia in neonates and young infants: US differentiation. (9807575)
1998
37
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
38
Comparison of hepaticoantrostomy and hepaticojejunostomy for biliary reconstruction after resection of a choledochal cyst. (9099644)
1997
39
Early presentation of choledochal cyst transiently obstructed by an inspissated bile plug. (9349790)
1997
40
Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. (8673308)
1996
41
Left hepatic choledochal cyst. (8784414)
1996
42
Early prenatal diagnosis of choledochal cyst. (8938064)
1996
43
Surgical treatment of choledochal cyst in adults: results and long-term follow-up. (9081911)
1996
44
Case report: giant choledochal cyst. (8889964)
1996
45
Choledochal cyst in pregnancy: a therapeutic dilemma. (7670683)
1995
46
Index of suspicion. Case 3. Diagnosis: Choledochal cyst. (7731913)
1995
47
Pancreatitis associated with choledochal cyst and other anomalies in childhood. (7627524)
1995
48
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst. (8405868)
1993
49
Radiological case of the month. Choledochal cyst. (8362794)
1993
50
Adenocarcinoma of the gallbladder associated with congenital choledochal cyst and anomalous pancreaticobiliary ductal junction. Case report. (1683581)
1991

Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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Search GEO for disease gene expression data for Choledochal Cyst.

Pathways for genes affiliated with Choledochal Cyst

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Pathways related to Choledochal Cyst according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VIM, DES
2
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6VIM, DES
39.1NOS2, REG1A
49.0NOS2, PTGS2
58.6NOS2, MMP1, PTGS2
68.6PTGS2, MMP1, NOS2

Compounds for genes affiliated with Choledochal Cyst

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Compounds related to Choledochal Cyst according to GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1taurodeoxycholate4310.1SCT, SST
2lafutidine4310.1SST, SCT
3loxiglumide4310.1SCT, SST
4orcein439.9DES, VIM
5s 100439.9VIM, DES
611-deoxy-pge1439.7PTGS2, MMP1
7meloxicam43 1210.6MMP1, PTGS2
82-arachidonoylglycerol43 2810.6VIM, PTGS2
9biotin43 24 1211.6DES, SCT, VIM
10hematoxylin439.5VIM, DES, MMP1
11procollagen439.5DES, VIM, MMP1
12toluidine439.5DES, VIM
13progestin439.5MMP1, VIM, DES
14nimesulide43 1210.5MMP1, PTGS2
15hydrocortisone43 2 59 1212.4SST, MMP1, VIM
16ketorolac43 1210.4NOS2, PTGS2
17prostaglandin f2alpha439.4MMP1, PTGS2, SST
18hyaluronic acid43 2410.3DES, MMP1, VIM
19norepinephrine43 24 1211.3SCT, MMP1, DES, SST
20mafp439.3NOS2, PTGS2
21formaldehyde43 2410.3VIM, DES, MMP1
22sodium azide439.2VIM, MMP1
23estradiol43 24 1211.2DES, MMP1, SCT, VIM
24cyclopentenone439.1NOS2, PTGS2
25lactate439.1MMP1, SST, DES, VIM
26ns 39843 5910.0NOS2, MMP1, PTGS2
27celecoxib43 59 28 49 24 1214.0NOS2, MMP1, PTGS2
28prostaglandin439.0VIM, PTGS2, SCT, MMP1
29pdtc439.0MMP1, NOS2, PTGS2
30egcg438.9NOS2, MMP1, PTGS2
31isoproterenol43 129.8SCT, VIM, NOS2, SST
32herbimycin a43 599.8MMP1, PTGS2, NOS2
33testosterone43 59 24 1211.8SST, DES, MMP1, VIM, SCT
34retinoic acid43 249.8VIM, SCT, DES, MMP1, SST
35curcumin438.6NOS2, PTGS2, MMP1
36actinomycin d438.5NOS2, DES, VIM, PTGS2
37h2o2438.5NOS2, MMP1, VIM, DES
38sb 20358043 599.5NOS2, MMP1, VIM, PTGS2
39acetylcholine43 49 28 24 1212.4NOS2, SST, VIM, DES, SCT
40adenylate438.4NOS2, DES, VIM, SCT, SST
41arginine438.4DES, SCT, VIM, SST, NOS2
42doxorubicin43 49 1210.3SST, MMP1, VIM, NOS2, DES
43pge2438.3SCT, PTGS2, NOS2, SST, MMP1
44serine438.3SCT, VIM, MMP1, DES, REG1A
45indomethacin43 28 59 1211.2PTGS2, SCT, MMP1, VIM, NOS2
46estrogen438.1NOS2, VIM, PTGS2, DES, MMP1
47cycloheximide438.1NOS2, VIM, MMP1, SST, PTGS2
48dexamethasone43 49 28 1211.1NOS2, SST, MMP1, VIM, PTGS2
49vegf437.7SST, MMP1, NOS2, VIM, PTGS2, DES
50genistein43 28 59 2 24 1212.6SST, VIM, PTGS2, NOS2, REG1A, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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Cellular components related to Choledochal Cyst according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.7SST, REG1A, MMP1, SCT

Biological processes related to Choledochal Cyst according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.6VIM, DES

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet