MCID: CHL052
MIFTS: 46

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Choledochal Cyst

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63Wikipedia, 32MalaCards
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Wikipedia:63 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and cholangiocarcinoma. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF-mediated glucocorticoid regulation. The compounds indomethacin and nimesulide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Choledochal Cyst

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

choledochal cyst 8
cystic dilatation of common bile duct 60
congenital choledochal cyst 8


External Ids:

Disease Ontology8 DOID:899
NCIt39 C2943
SNOMED-CT56 398197009, 30533003
MeSH34 D015529
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Clinical Features for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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32MalaCards
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MalaCards organs/tissues related to Choledochal Cyst:

32
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choledochal Cyst:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4REG1A, DES, SCT, CCS
2MP:00053867.9SCT, DES, SST, NOS2, PTGS2, VIM

Publications for Choledochal Cyst

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50PubMed
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Articles related to Choledochal Cyst:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Laparoscopic resection of choledochal cyst: report of a case. (23657070)
2013
2
Clinical analysis of liver fibrosis in choledochal cyst. (23975015)
2013
3
Jaundice and life-threatening hemobilia: an uncommon presentation of choledochal cyst. (23324023)
2013
4
Carcinoma gallbladder in a patient with choledochal cyst, cysto-hepatolithiasis, and simple liver cyst. (23929277)
2013
5
Hydatid cyst within a choledochal cyst. (24347872)
2013
6
One case of common bile duct cancer mimicking cystic neoplasm of the pancreas, arising 9 years after excision of a choledochal cyst. (23251896)
2012
7
Associations between pediatric choledochal cysts, biliary atresia, and congenital cardiac anomalies. (22572617)
2012
8
Management of choledochal cyst: Evolution with antenatal diagnosis and laparoscopic approach. (23248439)
2012
9
Choledochal cyst with ectopic distal location of the papilla of Vater. (22319748)
2011
10
Magnetic resonance cholangiopancreatography diagnosis of choledochal cyst involving the cystic duct: report of three cases. (21172959)
2011
11
Intralaparoscopic endoscopy: its value during laparoscopic repair of choledochal cyst. (21246203)
2011
12
An unusual endoscopic ultrasound image of the common bile duct. Biliary intraductal neoplasia in the choledochal cyst. (21110961)
2011
13
Type IV A choledochal cyst with cystic duct cyst. (20590899)
2010
14
Long-term outcomes after hepaticojejunostomy for choledochal cyst: a 10- to 27-year follow-up. (20152355)
2010
15
Hamartomatous polyp of the gallbladder with an associated choledochal cyst. (20966480)
2010
16
Biliary rhabdomyoscarcoma mimicking choledochal cyst. (19337643)
2009
17
Association of gastroschisis and choledochal cyst. (19302840)
2009
18
Biliary papillomatosis with adenocarcinoma arising in choledochal cyst. (20426283)
2009
19
Acidic and basic solutions dissolve protein plugs made of lithostathine complicating choledochal cyst/pancreaticobiliary maljunction. (18989781)
2009
20
An adult choledochal cyst--the magnetic resonance cholangiopancreatography findings: report of a case. (18958568)
2008
21
Chylous ascites following choledochal cyst excision and Ladd's procedure. (18928476)
2008
22
Pancreaticobiliary maljunction without bile duct dilatation in children: distinction from choledochal cyst. (18493212)
2008
23
Choledochal cyst and anomalous pancreaticobiliary ductal union in adults: radiological spectrum and complications. (18303283)
2008
24
Cholecystoduodenal fistula associated with choledochal cyst: a rare clinical entity. (18987941)
2008
25
Piezoelectric extracorporeal shockwave lithotripsy for bile duct stone formation after choledochal cyst excision. (17377828)
2007
26
A case report of a 39-year-old male with choledochal cyst mimicking pancreatic pseudocyst. (17523282)
2007
27
Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children. (16707978)
2006
28
An unusual case of Type IV(A) choledochal cyst with subaortic ventricular septal defect. (16635184)
2006
29
Dynamic study of pancreaticobiliary reflux using secretin-stimulated magnetic resonance cholangiopancreatography in patients with choledochal cysts. (17011263)
2006
30
Prenatal diagnosis of choledochal cyst by magnetic resonance cholangiography. (16799787)
2006
31
Hepatobiliary and pancreatic: anomalous pancreatobiliary junction with choledochal cyst. (16677171)
2006
32
Traumatic rupture of choledochal cyst in a child. (15750916)
2005
33
Laparoscopic resection of congenital choledochal cyst, hepaticojejunostomy, and externally made Roux-en-Y anastomosis. (15852291)
2005
34
Roux-en-Y hepaticojejunostomy or hepaticoduodenostomy for biliary reconstruction during the surgical treatment of choledochal cyst: which is better? (15372285)
2005
35
Single-stage reconstruction of perforated choledochal cyst: case report and review of the literature. (15986969)
2005
36
Choledochal cyst: a case report and review of literature. (15532237)
2004
37
Prenatal diagnosis of choledochal cyst using ultrasound and magnetic resonance imaging. (14971007)
2004
38
Experience of congenital choledochal cyst in adults:treatment, surgical procedures and clinical outcome in the Second Affiliated Hospital of Harbin Medical University. (15608395)
2004
39
Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts. (15628732)
2004
40
SCVIR 2002 film panel case 7: biliary obstruction secondary to a choledochal cyst. (12050309)
2002
41
Choledochal cyst and squamous-cell carcinoma of the biliary tract. (12380705)
2002
42
Congenital absence of the portal vein associated with focal nodular hyperplasia of the liver and congenital choledochal cyst: a case report. (11283891)
2001
43
Choledochal cyst associated with duodenal obstruction. (10945708)
2000
44
Intraoperative pancreatoscopy for pancreatic duct stone debris distal to the common channel in choledochal cyst. (11051170)
2000
45
Colonic atresia secondary to a choledochal cyst. (9639633)
1998
46
Cholangitis secondary to choledochal cyst in pregnancy and puerperium. (9412960)
1997
47
Does hyperamylasemia in choledochal cyst indicate true pancreatitis? An experimental study. (7547797)
1995
48
Acute pancreatitis with pseudocyst formation complicating pregnancy in a patient with a co-existent choledochal cyst. (8217984)
1993
49
Choledochal cyst in a neonate. (1601481)
1992
50
Choledochal cyst (a case report). (1784037)
1991

Genetic Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

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Pathways for genes affiliated with Choledochal Cyst

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PTGS2, NOS2
28.9PTGS2, NOS2, MMP1

Compounds for genes affiliated with Choledochal Cyst

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.6SCT
2nimesulide44 1111.3MMP1
3dexamethasone44 49 28 1113.3PTGS2
4taurodeoxycholate4410.3SST, SCT
5lafutidine4410.2SST, SCT
6loxiglumide4410.2SCT, SST
7norepinephrine44 11 2412.1MMP1, DES
8orcein4410.0VIM, DES
9estradiol44 11 2412.0DES, VIM
10s 1004410.0DES, VIM
11pge2449.9SST, PTGS2
12toluidine449.9DES, VIM
13sodium azide449.8MMP1, VIM
14reticulin449.8VIM, DES
1511-deoxy-pge1449.8MMP1, PTGS2
16acetylcholine44 49 28 11 2413.8SCT, NOS2, SST
17meloxicam44 1110.8MMP1, PTGS2
18ketorolac44 1110.8NOS2, PTGS2
19prostaglandin449.7SCT, VIM, MMP1
202-arachidonoylglycerol44 2810.7VIM, PTGS2
21biotin44 11 2411.7VIM, DES, SCT
22mafp449.7NOS2, PTGS2
23mucicarmine449.6DES, VIM
24hematoxylin449.6DES, MMP1, VIM
25progestin449.6DES, VIM, MMP1
26cyclopentenone449.6PTGS2, NOS2
27hydrocortisone44 2 59 1112.6VIM, SST, MMP1
28prostaglandin f2alpha449.5PTGS2, MMP1, SST
29ns 39844 5910.4MMP1, NOS2, PTGS2
30trypsinogen449.4SCT, REG1A
31hyaluronic acid44 2410.3DES, MMP1, VIM
32celecoxib44 59 28 49 11 2414.3PTGS2, MMP1, NOS2
33pdtc449.3PTGS2, NOS2, MMP1
34formaldehyde44 2410.3DES, MMP1, VIM
35isoproterenol44 1110.3NOS2, VIM, SCT, SST
36lactate449.2SST, MMP1, DES, VIM
37clodronate44 49 1111.1PTGS2, MMP1
38herbimycin a44 5910.1NOS2, PTGS2, MMP1
39testosterone44 59 11 2412.0VIM, SCT, DES, SST, MMP1
40adenylate448.9NOS2, DES, SCT, VIM, SST
41retinoic acid44 249.9VIM, SCT, MMP1, DES, SST
42sb 20358044 599.9MMP1, VIM, PTGS2, NOS2
43cysteine448.9CCS, MMP1, DES, SCT, VIM
44actinomycin d448.9PTGS2, VIM, NOS2, DES
45arginine448.9VIM, SCT, NOS2, DES, SST
46curcumin448.8MMP1, PTGS2, NOS2
47doxorubicin44 49 1110.8VIM, SST, DES, NOS2, MMP1
48estrogen448.4NOS2, DES, VIM, PTGS2, MMP1
49vegf448.2VIM, SST, MMP1, NOS2, PTGS2, DES
50genistein44 28 59 2 11 2412.8NOS2, PTGS2, REG1A, SST, VIM, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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16Gene Ontology
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Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide metabolic processGO:0068019.6NOS2, CCS

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet