MCID: CHL052
MIFTS: 46

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Choledochal Cyst

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63Wikipedia, 32MalaCards
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Wikipedia:63 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and cholangiocarcinoma. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF-mediated glucocorticoid regulation. The compounds indomethacin and nimesulide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Choledochal Cyst

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

choledochal cyst 8
cystic dilatation of common bile duct 60
congenital choledochal cyst 8


External Ids:

Disease Ontology8 DOID:899
NCIt39 C2943
SNOMED-CT56 398197009, 30533003
MeSH34 D015529
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Clinical Features for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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32MalaCards
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MalaCards organs/tissues related to Choledochal Cyst:

32
Pancreas, Liver, Colon, Kidney, Testes, Heart, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choledochal Cyst:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4REG1A, DES, SCT, CCS
2MP:00053867.9SCT, DES, SST, NOS2, PTGS2, VIM

Publications for Choledochal Cyst

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50PubMed
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Articles related to Choledochal Cyst:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Surgical treatment of type IV-A choledochal cyst in a single institution: children vs. adults. (24094958)
2013
2
Liver transplantation from a donor with asymptomatic type IV-a choledochal cyst: the long-term postoperative course. (23263448)
2012
3
Laparoscopic surgery for biliary atresia and choledochal cyst. (22800973)
2012
4
Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cyst. (21238669)
2011
5
Spontaneously ruptured choledochal cyst: Rare diagnosis on hepatic scintigraphy. (23326070)
2011
6
Suspected choledochal cyst in a domestic shorthair cat. (20724187)
2010
7
Type IVa choledochal cyst: Results following haemihepatectomy and mucosectomy of intrahepatic cyst. (23133206)
2010
8
Bilateral single-system ectopic ureter associated with choledochal cyst: report of 2 cases. (21129566)
2010
9
Laparoscopic repair for choledochal cyst: lessons learned from 190 cases. (20223317)
2010
10
A case of a choledochal cyst associated with a lymphatic infiltration of a hyperplastic gallbladder epithelium. (19361649)
2009
11
Adenosquamous carcinoma in a congenital choledochal cyst associated with pancreatico-biliary maljunction. (19563412)
2009
12
Choledochal cyst type IA with drainage through the ventral duct in pancreas divisum. (19319788)
2009
13
The changing presentation of choledochal cyst disease: an incidental diagnosis. (19841688)
2009
14
Neuroendocrine tumor of the common hepatic duct, mimicking a choledochal cyst in a 6-year-old child. (19524713)
2009
15
Colonic atresia and choledochal cyst: a rare combination. (18985360)
2009
16
Fetal choledochal cyst diagnosed at 22 weeks of gestation by three-dimensional ultrasonography: a case report. (18955804)
2008
17
Laparoscopic correction of biliary duct stenosis in choledochal cyst. (18405709)
2008
18
Choledochal cyst associated with an accessory hepatic duct identified by intra-operative endoscopy: case report and literature review. (18682962)
2008
19
Image of the month. Choledochal cyst, Todani type I. (17938316)
2007
20
Adult choledochal cyst. (17236851)
2007
21
Value of hepatobiliary scintigraphy after type 1 choledochal cyst excision and Roux-en-Y hepatojejunostomy. (16424696)
2006
22
Endoscopic resection of intrahepatic septal stenosis: minimally invasive approach to manage hepatolithiasis after choledochal cyst excision. (16927093)
2006
23
Is excision of a choledochal cyst in the neonatal period necessary? (17161187)
2006
24
Pancreatitis complicated with dilated choledochal remnant after congenital choledochal cyst excision. (16195912)
2005
25
Spontaneous rupture of choledochal cyst presenting in childhood. (16250318)
2005
26
Is there an association between duodenal atresia and choledochal cyst? (15735498)
2005
27
Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children. (14666479)
2003
28
Protein stone formation in an intrapancreatic remnant cyst after resection of a choledochal cyst. (12717276)
2003
29
Obstructive jaundice caused by primary choledochal hydatid cyst mimicking radiologically choledochal cyst. (12596118)
2003
30
Choledochal cyst in a pediatric patient: creation of a bilijejunal anastomosis with surgical staples. A case report. (15070273)
2003
31
Choledochal cyst associated with portal hypertension. (14704806)
2003
32
Pleuro-biliary fistula from a ruptured choledochal cyst. (11167116)
2001
33
Pancreatic complications in choledochal cyst and their surgical outcomes. (11775184)
2001
34
Intraductal US aids detection of carcinoma in situ in a patient with a choledochal cyst. (11174304)
2001
35
Laparoscopic excision of a rare type II choledochal cyst: case report and review of the literature. (10917310)
2000
36
A rare malformation of the pancreaticobiliary junction long common channel choledochal cyst and pancreas divisum in a patient with pancreatic cancer. (10430313)
1999
37
Comparison of hepaticoantrostomy and hepaticojejunostomy for biliary reconstruction after resection of a choledochal cyst. (9099644)
1997
38
Porta choledochal fistula: an unusual complication of a cholangiocarcinoma arising from a type I choledochal cyst. (9158199)
1997
39
Hepaticoenterostomy after excision of choledochal cyst in children: a 30-year experience with 180 cases. (8906676)
1996
40
Choledochal cyst misinterpreted as a biloma after a blunt abdominal trauma. (8998326)
1996
41
Unusual presentation of an unusual type of choledochal cyst. (7572916)
1995
42
Malignant potential of the gallbladder in patients with anomalous pancreaticobiliary ductal junction. The difference in risk between patients with and without choledochal cyst. (7657495)
1995
43
Form fruste choledochal cyst. (8617565)
1995
44
Choledochal cyst mimicking a pancreatic pseudocyst. (7769195)
1995
45
Choledochal cyst disease. A changing pattern of presentation. (7979612)
1994
46
Radiological case of the month. Choledochal cyst. (8362794)
1993
47
A case of type 3 choledochal cyst masquerading as acute abdominal pain. (8509056)
1993
48
Narrow duct segment distal to choledochal cyst. (1882808)
1991
49
ERCP in the evaluation of choledochal cyst due to anomalous pancreatobiliary junction. (1885495)
1991
50
Choledochal cyst and chronic pancreatitis--treated by proximal pancreatectomy. (1681890)
1991

Genetic Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

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Pathways for genes affiliated with Choledochal Cyst

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PTGS2, NOS2
28.9PTGS2, NOS2, MMP1

Compounds for genes affiliated with Choledochal Cyst

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.6SCT
2nimesulide44 1111.3MMP1
3dexamethasone44 49 28 1113.3PTGS2
4taurodeoxycholate4410.2SCT, SST
5lafutidine4410.2SST, SCT
6loxiglumide4410.2SST, SCT
7norepinephrine44 11 2412.1MMP1, DES
8orcein4410.0VIM, DES
9estradiol44 11 2412.0VIM, DES
10s 1004410.0DES, VIM
11pge2449.9PTGS2, SST
12toluidine449.9VIM, DES
13sodium azide449.8VIM, MMP1
14reticulin449.8DES, VIM
1511-deoxy-pge1449.8MMP1, PTGS2
16acetylcholine44 49 28 11 2413.8SCT, SST, NOS2
17meloxicam44 1110.8MMP1, PTGS2
18ketorolac44 1110.8NOS2, PTGS2
19prostaglandin449.7MMP1, SCT, VIM
202-arachidonoylglycerol44 2810.7VIM, PTGS2
21biotin44 11 2411.7DES, SCT, VIM
22mafp449.7NOS2, PTGS2
23mucicarmine449.6VIM, DES
24hematoxylin449.6VIM, DES, MMP1
25progestin449.6VIM, DES, MMP1
26cyclopentenone449.6PTGS2, NOS2
27hydrocortisone44 2 59 1112.6VIM, SST, MMP1
28prostaglandin f2alpha449.5PTGS2, MMP1, SST
29ns 39844 5910.4MMP1, NOS2, PTGS2
30trypsinogen449.4REG1A, SCT
31hyaluronic acid44 2410.3VIM, DES, MMP1
32celecoxib44 59 28 49 11 2414.3MMP1, NOS2, PTGS2
33pdtc449.3PTGS2, NOS2, MMP1
34formaldehyde44 2410.3MMP1, DES, VIM
35isoproterenol44 1110.3VIM, SCT, SST, NOS2
36lactate449.2MMP1, SST, DES, VIM
37clodronate44 49 1111.1PTGS2, MMP1
38herbimycin a44 5910.1MMP1, NOS2, PTGS2
39testosterone44 59 11 2412.0MMP1, SST, DES, SCT, VIM
40adenylate448.9VIM, SCT, DES, SST, NOS2
41retinoic acid44 249.9MMP1, SST, DES, SCT, VIM
42sb 20358044 599.9VIM, MMP1, NOS2, PTGS2
43cysteine448.9VIM, CCS, SCT, DES, MMP1
44actinomycin d448.9PTGS2, NOS2, DES, VIM
45arginine448.9VIM, SCT, DES, SST, NOS2
46curcumin448.8PTGS2, NOS2, MMP1
47doxorubicin44 49 1110.8NOS2, MMP1, SST, DES, VIM
48estrogen448.4PTGS2, NOS2, MMP1, DES, VIM
49vegf448.2VIM, DES, SST, MMP1, NOS2, PTGS2
50genistein44 28 59 2 11 2412.8PTGS2, NOS2, MMP1, REG1A, SST, VIM

GO Terms for genes affiliated with Choledochal Cyst

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16Gene Ontology
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Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide metabolic processGO:0068019.6NOS2, CCS

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet