MCID: CHL052
MIFTS: 51

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Choledochal Cyst

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Wikipedia:65 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards based summary: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and acute pancreatitis. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds taurodeoxycholate and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are muscle and nervous system.

Aliases & Classifications for Choledochal Cyst

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Choledochal Cyst, Aliases & Descriptions:

Name: Choledochal Cyst 8
Cystic Dilatation of Common Bile Duct 62
 
Congenital Choledochal Cyst 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:899
MeSH34 D015529
SNOMED-CT57 30533003, 398197009
NCIt39 C2943
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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Diseases related to Choledochal Cyst via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.6SCT, REG1A, SST
2acute pancreatitis31.0SST, REG1A, SCT
3cholangiocarcinoma30.9PTGS2, SCT
4neuroendocrine tumor30.6SCT, SST
5adenoma30.1SCT, PTGS2, REG1A, SST
6pancreatic cancer29.8SCT, PTGS2, REG1A, SST
7adenocarcinoma29.7SCT, PTGS2, VIM, REG1A, SST, NOS2
8biliary atresia10.7
9hepatitis10.7
10duodenitis10.6
11rhabdomyosarcoma10.5
12infantile myofibromatosis10.5DES
13angiodysplasia10.5SST
14dumping syndrome10.5SST
15obstructive jaundice10.5
16biliary papillomatosis10.5
17bile duct cysts10.5
18collagenous colitis10.4NOS2
19hypertension10.4
20portal hypertension10.4
21duodenal atresia10.4
22adenomatoid tumor10.4VIM
23cholelithiasis10.3
24cholangitis10.3
25duodenal obstruction10.3
26embryonal rhabdomyosarcoma10.3
27intrahepatic cholangiocarcinoma10.3
28peritonitis10.3
29chylous ascites10.3
30colonic atresia10.3
31hyperinsulinemic hypoglycemia10.3SST, SCT
32vipoma10.3SCT, SST
33zollinger-ellison syndrome10.3SCT, SST
34steatorrhea10.3SCT, SST
35pancreas disease10.3REG1A, SCT
36atrophic gastritis10.3SCT, SST
37glucagonoma10.3SCT, SST
38duodenal ulcer10.3SST, SCT
39gastrinoma10.3SCT, SST
40gastritis10.3SCT, NOS2
41cystadenoma10.3
42lymphangitis10.3
43cholecystitis10.3
44wermer syndrome10.3SST, SCT
45lymphangioleiomyomatosis10.3DES, MMP1
46fibromatosis10.2VIM, DES
47epithelioid leiomyosarcoma10.2VIM, DES
48mesenchymal chondrosarcoma10.2VIM, DES
49pseudosarcomatous fibromatosis10.2DES, VIM
50spindle cell carcinoma10.2VIM, DES

Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Symptoms for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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Drug clinical trials:

Search ClinicalTrials for Choledochal Cyst

Search NIH Clinical Center for Choledochal Cyst

Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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MalaCards organs/tissues related to Choledochal Cyst:

32
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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MGI Mouse Phenotypes related to Choledochal Cyst:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0DES, PTGS2, VIM, NOS2
2MP:00036317.8NOS2, SST, VIM, PTGS2, SCT
3MP:00053867.4DES, SCT, PTGS2, VIM, SST, NOS2
4MP:00053877.3PTGS2, VIM, MMP1, SST, NOS2
5MP:00053766.5NOS2, DES, SCT, PTGS2, VIM, MMP1

Publications for Choledochal Cyst

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Articles related to Choledochal Cyst:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Coagulopathy in a subtype of choledochal cyst and management strategy. (25132782)
2014
2
Choledochal cyst - a different disease in newborns and infants. (25404451)
2014
3
Mid-term Outcomes of Laparoscopic Versus Open Choledochal Cyst Excision in a Tertiary Paediatric Hospital. (24833074)
2014
4
Laparoscopic resection of choledochal cyst: report of a case. (23657070)
2013
5
Early experience of laparoscopic choledochal cyst excision in children. (24266013)
2013
6
Intact Choledochal Cyst with Spontaneous Common Hepatic Duct Perforation: A Spectrum of Congenital Biliary Canal Defects? (23343939)
2013
7
Unexpected small bowel polyposis in a man with a choledochal cyst, more than a difficult cannulation. (22906397)
2012
8
Choledochal cyst: presentation of the disease with a case report. (21875424)
2011
9
The effect of laparoscopic excision vs open excision in children with choledochal cyst: a midterm follow-up study. (21496534)
2011
10
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
11
Type IV A choledochal cyst with cystic duct cyst. (20590899)
2010
12
Adult type I choledochal cyst resection. (18446417)
2009
13
Choledochal cyst associated with duodenal atresia: case report and review of the literature. (19693517)
2009
14
Choledochal cyst during pregnancy: the patient's first pregnancy was complicated by a congenital anomaly. (19375577)
2009
15
Biliary rhabdomyoscarcoma mimicking choledochal cyst. (19337643)
2009
16
Choledochal cyst as a diagnostic pitfall: a case report. (18194562)
2008
17
Fetal choledochal cyst diagnosed at 22 weeks of gestation by three-dimensional ultrasonography: a case report. (18955804)
2008
18
An adult choledochal cyst--the magnetic resonance cholangiopancreatography findings: report of a case. (18958568)
2008
19
Image of the month. Choledochal cyst, Todani type I. (17938316)
2007
20
Aplasia of the dorsal pancreas and choledochal cyst. (16474976)
2006
21
Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children. (16707978)
2006
22
Type IV-a choledochal cyst--a rare adolescent presentation as acute abdomen. (16909261)
2006
23
Spontaneous rupture of a type IVA choledochal cyst in a young adult during radiological imaging. (16521234)
2006
24
Pancreatitis complicated with dilated choledochal remnant after congenital choledochal cyst excision. (16195912)
2005
25
Traumatic rupture of choledochal cyst in a child. (15750916)
2005
26
Embryonal rhabdomyosarcoma of the common bile duct mimicking choledochal cyst. (15995817)
2005
27
A retrospective study of choledochal cyst: clinical presentation, diagnosis and treatment. (14768797)
2003
28
Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children. (14666479)
2003
29
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. (11290894)
2001
30
Massive dilatation of the common bile duct resembling a choledochal cyst. (11963332)
2001
31
Carcinoma of the head of the pancreas after excision of a choledochal cyst. (11379358)
2001
32
Anomalous pancreaticobiliary junction without congenital choledochal cyst. (10419333)
1999
33
Choledochal cyst associated with polycystic kidney disease: report of a case. (10371064)
1999
34
Choledochal cyst in Simpson-Golabi-Behmel syndrome. (10564884)
1999
35
Incomplete pancreas divisum with anomalous choledochopancreatic duct junction with choledochal cyst. (10522863)
1999
36
Choledochal cyst: review of 74 pediatric cases. (9737111)
1998
37
Choledochal cyst with or without biliary atresia in neonates and young infants: US differentiation. (9807575)
1998
38
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
39
Comparison of hepaticoantrostomy and hepaticojejunostomy for biliary reconstruction after resection of a choledochal cyst. (9099644)
1997
40
Early presentation of choledochal cyst transiently obstructed by an inspissated bile plug. (9349790)
1997
41
Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. (8673308)
1996
42
Left hepatic choledochal cyst. (8784414)
1996
43
Early prenatal diagnosis of choledochal cyst. (8938064)
1996
44
Surgical treatment of choledochal cyst in adults: results and long-term follow-up. (9081911)
1996
45
Case report: giant choledochal cyst. (8889964)
1996
46
Index of suspicion. Case 3. Diagnosis: Choledochal cyst. (7731913)
1995
47
Pancreatitis associated with choledochal cyst and other anomalies in childhood. (7627524)
1995
48
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst. (8405868)
1993
49
Radiological case of the month. Choledochal cyst. (8362794)
1993
50
Adenocarcinoma of the gallbladder associated with congenital choledochal cyst and anomalous pancreaticobiliary ductal junction. Case report. (1683581)
1991

Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

Search GEO for disease gene expression data for Choledochal Cyst.

Pathways for genes affiliated with Choledochal Cyst

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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VIM, DES
2
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.6VIM, DES
39.1NOS2, REG1A
49.0NOS2, PTGS2
58.6NOS2, MMP1, PTGS2
68.6PTGS2, MMP1, NOS2

Compounds for genes affiliated with Choledochal Cyst

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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1taurodeoxycholate4410.1SCT, SST
2lafutidine4410.1SST, SCT
3loxiglumide4410.1SCT, SST
4orcein449.9DES, VIM
5s 100449.9VIM, DES
611-deoxy-pge1449.7PTGS2, MMP1
7meloxicam44 1110.6MMP1, PTGS2
82-arachidonoylglycerol44 2810.6VIM, PTGS2
9biotin44 24 1111.6DES, SCT, VIM
10hematoxylin449.5VIM, DES, MMP1
11procollagen449.5DES, VIM, MMP1
12toluidine449.5DES, VIM
13progestin449.5MMP1, VIM, DES
14nimesulide44 1110.5MMP1, PTGS2
15hydrocortisone44 2 61 1112.4SST, MMP1, VIM
16ketorolac44 1110.4NOS2, PTGS2
17prostaglandin f2alpha449.4MMP1, PTGS2, SST
18hyaluronic acid44 2410.3DES, MMP1, VIM
19norepinephrine44 24 1111.3SCT, MMP1, DES, SST
20mafp449.3NOS2, PTGS2
21formaldehyde44 2410.3VIM, DES, MMP1
22sodium azide449.2VIM, MMP1
23estradiol44 24 1111.2DES, MMP1, SCT, VIM
24cyclopentenone449.1NOS2, PTGS2
25lactate449.1MMP1, SST, DES, VIM
26ns 39844 6110.0NOS2, MMP1, PTGS2
27celecoxib44 61 28 50 24 1114.0NOS2, MMP1, PTGS2
28prostaglandin449.0VIM, PTGS2, SCT, MMP1
29pdtc449.0MMP1, NOS2, PTGS2
30egcg448.9NOS2, MMP1, PTGS2
31isoproterenol44 119.8SCT, VIM, NOS2, SST
32herbimycin a44 619.8MMP1, PTGS2, NOS2
33testosterone44 61 24 1111.8SST, DES, MMP1, VIM, SCT
34retinoic acid44 249.8VIM, SCT, DES, MMP1, SST
35curcumin448.6NOS2, PTGS2, MMP1
36actinomycin d448.5NOS2, DES, VIM, PTGS2
37h2o2448.5NOS2, MMP1, VIM, DES
38sb 20358044 619.5NOS2, MMP1, VIM, PTGS2
39acetylcholine44 50 28 24 1112.4NOS2, SST, VIM, DES, SCT
40adenylate448.4NOS2, DES, VIM, SCT, SST
41arginine448.4DES, SCT, VIM, SST, NOS2
42doxorubicin44 50 1110.3SST, MMP1, VIM, NOS2, DES
43pge2448.3SCT, PTGS2, NOS2, SST, MMP1
44serine448.3SCT, VIM, MMP1, DES, REG1A
45indomethacin44 28 61 1111.2PTGS2, SCT, MMP1, VIM, NOS2
46estrogen448.1NOS2, VIM, PTGS2, DES, MMP1
47cycloheximide448.1NOS2, VIM, MMP1, SST, PTGS2
48dexamethasone44 50 28 1111.1NOS2, SST, MMP1, VIM, PTGS2
49vegf447.7SST, MMP1, NOS2, VIM, PTGS2, DES
50genistein44 28 61 2 24 1112.6SST, VIM, PTGS2, NOS2, REG1A, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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Cellular components related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7SST, REG1A, MMP1, SCT

Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6VIM, DES

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
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