MCID: CHL052
MIFTS: 39

Choledochal Cyst

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Choledochal Cyst

MalaCards integrated aliases for Choledochal Cyst:

Name: Choledochal Cyst 12 56 42 14 69
Congenital Cystic Dilatation of the Biliary Tract 56
Congenital Choledochal Cyst 12

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:899
ICD10 33 Q44.4
MeSH 42 D015529
NCIt 47 C2943
Orphanet 56 ORPHA480501
UMLS 69 C0008340

Summaries for Choledochal Cyst

MalaCards based summary : Choledochal Cyst, also known as congenital cystic dilatation of the biliary tract, is related to xanthogranulomatous cholecystitis and gallbladder cancer. An important gene associated with Choledochal Cyst is SST (Somatostatin), and among its related pathways/superpathways are Pathways in cancer and Colorectal Cancer Metastasis. The drugs Etomidate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon, and related phenotype is skeleton.

Wikipedia : 72 Choledochal cysts (a.k.a. bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

Related Diseases for Choledochal Cyst

Diseases related to Choledochal Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 xanthogranulomatous cholecystitis 30.2 MMP1 MMP2
2 gallbladder cancer 29.6 KRAS MMP2
3 bile duct cysts 11.5
4 duodenal atresia 11.3
5 bile duct carcinoma 11.3
6 bile acid synthesis defect, congenital, 2 10.9
7 cholangiocarcinoma, susceptibility to 10.9
8 pancreatitis 10.5
9 kleptomania 10.5 MMP1 MMP2
10 limbic encephalitis 10.4 MMP1 MMP2
11 gait apraxia 10.4 MMP1 MMP2
12 adenosine monophosphate deaminase 1 deficiency 10.4 MMP1 MMP2
13 oligomeganephronic renal hypoplasia 10.4 MMP1 MMP2
14 skin amelanotic melanoma 10.4 MMP1 MMP2
15 limb ischemia 10.4 KRAS SST
16 bleeding disorder, platelet-type, 21 10.4 MMP1 MMP2
17 rare endometriosis 10.4 MMP1 MMP2
18 tabes dorsalis 10.3 KRAS SST
19 laryngostenosis 10.3 MMP1 MMP2
20 hepatitis 10.3
21 fibroma 10.3 KRAS SST
22 migraine with aura 10.3 KRAS SST
23 biliary atresia 10.3
24 mastoiditis 10.3 MMP1 MMP2
25 optic papillitis 10.3 KRAS SST
26 spindle epithelial tumor with thymus-like differentiation tumor 10.3 KRAS MMP2
27 salt and pepper syndrome 10.3 MMP1 MMP2
28 dental caries 10.2 KRAS MMP2
29 nasal cavity disease 10.2 KRAS MMP2
30 congenital heart defects and skeletal malformations syndrome 10.1 MMP1 MMP2
31 male reproductive organ benign neoplasm 10.1 KRAS SST
32 duodenitis 10.1
33 acute pancreatitis 10.1
34 adenocarcinoma 10.1
35 rhabdomyosarcoma 10.1
36 senior-loken syndrome-1 10.1 TMEM67 WDR19
37 obstructive jaundice 10.0
38 trachea squamous cell carcinoma 10.0 KRAS MMP2
39 portal hypertension 10.0
40 biliary papillomatosis 10.0
41 benign shuddering attacks 10.0 KRAS SST
42 pancreatic acth hormone producing tumor 10.0 MMP1 MMP2
43 colonic atresia 9.9
44 cholelithiasis 9.9
45 cystadenoma 9.9
46 embryonal rhabdomyosarcoma 9.9
47 duodenal obstruction 9.9
48 intrahepatic cholangiocarcinoma 9.9
49 peritonitis 9.9
50 cholangitis 9.9

Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to Choledochal Cyst

Symptoms & Phenotypes for Choledochal Cyst

MGI Mouse Phenotypes related to Choledochal Cyst:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.02 KRAS MMP2 SST TMEM67 WDR19

Drugs & Therapeutics for Choledochal Cyst

Drugs for Choledochal Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Butyric Acid Experimental Phase 4 107-92-6 264
6 Adjuvants, Anesthesia Phase 4
7 Anesthetics Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Anti-Anxiety Agents Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 Cortisol succinate Phase 4
14 GABA Agents Phase 4
15 GABA Modulators Phase 4
16 Hydrocortisone 17-butyrate 21-propionate Phase 4
17 Hydrocortisone acetate Phase 4
18 Hydrocortisone-17-butyrate Phase 4
19 Hypnotics and Sedatives Phase 4
20 Neurotransmitter Agents Phase 4
21 Psychotropic Drugs Phase 4
22 Tranquilizing Agents Phase 4
23
Pancrelipase Approved 53608-75-6
24 Alpha 1-Antitrypsin
25 Liver Extracts
26 pancreatin
27 Protein C Inhibitor

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
2 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
3 Superior Bilioenteric Anastomosis by Magnetic Compressive Technique Recruiting NCT02801500
4 Shear Wave Sonoelastography in Pediatric Liver Fibrosis Recruiting NCT02372682
5 UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource Recruiting NCT01401998
6 Clinical and Molecular Investigations Into Ciliopathies Recruiting NCT00068224
7 Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses Not yet recruiting NCT03252379

Search NIH Clinical Center for Choledochal Cyst

Cochrane evidence based reviews: choledochal cyst

Genetic Tests for Choledochal Cyst

Anatomical Context for Choledochal Cyst

MalaCards organs/tissues related to Choledochal Cyst:

39
Liver, Pancreas, Colon, Kidney, Appendix, Testes, Skin

Publications for Choledochal Cyst

Articles related to Choledochal Cyst:

(show top 50) (show all 618)
id Title Authors Year
1
An impressive choledochal cyst and its surgical resection. ( 28273606 )
2017
2
The efficacy of resection of intrahepatic bile duct stenosis-causing membrane or septum for preventing hepatolithiasis after choledochal cyst excision. ( 28927985 )
2017
3
Ectopic Hepatocellular Carcinoma within a Choledochal Cyst Diagnosed Using Single-Operator Digital Cholangioscopy. ( 28766569 )
2017
4
Primary Epidermoid Cyst of Biliary Duct Presenting as Choledochal Cyst. ( 28508685 )
2017
5
Laparoscopic excision of the choledochal cyst in adult patients: An experience. ( 28872095 )
2017
6
Giant Choledochal Cyst in A Neonate. ( 28083508 )
2017
7
Single-stage operation for perforated choledochal cyst. ( 28774506 )
2017
8
Choledochal Cyst with 17q12 Chromosomal Duplication. ( 28940454 )
2017
9
Spontaneous Rupture of a Choledochal Cyst During Post Partum: A Rare Presentation. ( 28496535 )
2017
10
Bile Duct Adenocarcinoma with Acute on Chronic Pancreatitis: A Rare Complication of Long Standing Choledochal Cyst. ( 28764249 )
2017
11
Different clinical presentations of choledochal cyst among infants and older children: A 10-year retrospective study. ( 28445267 )
2017
12
Cystic Biliary Atresia and Choledochal Cysts are Distinct Histopathologic Entities. ( 28079575 )
2017
13
The distal classification and management of choledochal cyst in adults: Based on the relation between cyst and pancreatic duct. ( 28328818 )
2017
14
External Drainage of Giant Infantile Choledochal Cyst before Definitive Repair: Is it Worth? ( 28892977 )
2017
15
Laparoscopic Management of a Proximal Jejunal Gallstone Ileus with Patulous Ampulla and Choledochal Cyst-a Report of Unusual Presentation and a Review. ( 28331267 )
2017
16
Duodenogastric regurgitation in hepaticoduodenostomy after excision of congenital biliary dilatation (choledochal cyst). ( 28410789 )
2017
17
A rare case of choledochal cyst with pancreas divisum: case presentation and literature review. ( 28317046 )
2017
18
Modified biliary-enteric anastomosis for congenital choledochal cyst: clinical and prognostic analysis of 91 cases. ( 28289881 )
2017
19
Isolated dilatation of the cystic duct-Type VI choledochal cyst: a rare case presentation and review of the literature. ( 28458872 )
2017
20
Heterotopic pancreatic tissue associated with type 1 choledochal cyst, cystolithiasis and gall bladder stones: a rare entity with review of literature. ( 28396555 )
2017
21
Percutaneous Transhepatic Angioplasty for Portal Vein Cavernous Transformation after Choledochal Cyst Surgery. ( 28064268 )
2016
22
Treatment of choledochal cyst in a pediatric population. A single institution experience of 15-years. Case series. ( 26900456 )
2016
23
A giant choledochal cyst in infancy: a case report. ( 27279889 )
2016
24
Choledochal cyst: a future indication for peroral choledochoscopy? ( 27852091 )
2016
25
Rupture of a Choledochal Cyst in an Adult Female: A Rare Consequence of Blunt Abdominal Trauma. ( 27647205 )
2016
26
Gallbladder Volvulus in a Patient with Type I Choledochal Cyst: A Case Report and Review of the Literature. ( 27747125 )
2016
27
Laparoscopic choledochal cyst excision and Roux-en-Y hepaticojejunostomy. ( 27436941 )
2016
28
Traumatic Rupture of Choledochal Cyst in Children: Use of Computed Tomography in the Emergency Department. ( 26928097 )
2016
29
Clinical effects in resection of congenital choledochal cyst of children and jejunum Roux-Y anastomosis by laparoscope. ( 27874945 )
2016
30
Management of Adult Choledochal Cyst Coexisting with Gallbladder Carcinoma: A Case Report and Review of Literature. ( 27013859 )
2016
31
Dilatation of the Proximal Cystic Duct: Is It a Variant to "Type VI" Choledochal Cyst? ( 27504348 )
2016
32
Laparoscopic Treatment of Choledochal Cyst Using Barbed Sutures. ( 27200460 )
2016
33
The presentation and management of choledochocele (type III choledochal cyst): A 40-year systematic review of the literature. ( 27829523 )
2016
34
Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst: a link between choledochal cyst and gallbladder cancer? ( 27480698 )
2016
35
Endoscopic Ultrasound Images of a Choledochal Cyst Mimicking a Pregnant Uterus. ( 27924091 )
2016
36
Increased survivin expression and its association with clinical parameters of congenital choledochal cysts. ( 27420945 )
2016
37
Choledochal cyst in pregnancy. ( 28491243 )
2016
38
Evaluation of the learning curve of laparoscopic choledochal cyst excision and Roux-en-Y hepaticojejunostomy in children: CUSUM analysis of a single surgeon's experience. ( 27338584 )
2016
39
A variant of type VI choledochal cyst: combined dilatation of cystic duct and common bile duct. ( 26941882 )
2016
40
Ciliated Foregut Cyst of the Common Hepatic Duct: An Unusual Mimic of a Type II Choledochal Cyst. ( 27166199 )
2016
41
Significance of imaging modalities for preoperative evaluation of the pancreaticobiliary system in surgery for pediatric choledochal cyst. ( 26994400 )
2016
42
Laparoscopic treatment of congenital choledochal cyst and hepaticojejunostomy with extracorporeal Roux-en-Y anastomosis: technical aspects and early experience with three cases. ( 27345604 )
2016
43
Cholangiocarcinoma in choledochal cyst after cystoenterostomy: how a mistreated choledochal cyst can progress to malignancy. ( 28261701 )
2016
44
Type VI Choledochal Cyst-An Unusual Presentation of Jaundice. ( 27867293 )
2016
45
Todani choledochal cyst type II: case report and review. ( 27813504 )
2016
46
Choledochal cyst Todani IA case report. ( 27769027 )
2016
47
Cosmetic selection of skin incision for resection of choledochal cyst in young female patients. ( 27621750 )
2016
48
Laparoscopic management of antenatally detected choledochal cyst: a 10-year review. ( 27129540 )
2016
49
Hepatopancreatoduodenectomy for local recurrence of cholangiocarcinoma after excision of a type IV-A congenital choledochal cyst: a case report. ( 26943695 )
2016
50
Diagnosis of type IV-A congenital choledochal cyst in a 73-year-old man. ( 27895454 )
2016

Variations for Choledochal Cyst

Expression for Choledochal Cyst

Search GEO for disease gene expression data for Choledochal Cyst.

Pathways for Choledochal Cyst

GO Terms for Choledochal Cyst

Biological processes related to Choledochal Cyst according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.96 MMP1 MMP2
2 collagen catabolic process GO:0030574 8.62 MMP1 MMP2

Sources for Choledochal Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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