MCID: CHL052
MIFTS: 50

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Choledochal Cyst

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66Wikipedia, 34MalaCards
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Wikipedia:66 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and cholangiocarcinoma. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds taurodeoxycholate and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are muscle and nervous system.

Aliases & Classifications for Choledochal Cyst

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

choledochal cyst 9
cystic dilatation of common bile duct 63
congenital choledochal cyst 9


External Ids:

Disease Ontology9 DOID:899
NCIt41 C2943
SNOMED-CT59 398197009, 30533003
MeSH36 D015529
ICD1026 Q44.4

Related Diseases for Choledochal Cyst

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Symptoms for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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34MalaCards
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MalaCards organs/tissues related to Choledochal Cyst:

34
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Choledochal Cyst:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0DES, PTGS2, VIM, NOS2
2MP:00036317.8NOS2, SST, VIM, PTGS2, SCT
3MP:00053867.4DES, SCT, PTGS2, VIM, SST, NOS2
4MP:00053877.3PTGS2, VIM, MMP1, SST, NOS2
5MP:00053766.5NOS2, DES, SCT, PTGS2, VIM, MMP1

Publications for Choledochal Cyst

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53PubMed
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Articles related to Choledochal Cyst:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Laparoscopic resection of choledochal cyst: report of a case. (23657070)
2013
2
Early experience of laparoscopic choledochal cyst excision in children. (24266013)
2013
3
Intact Choledochal Cyst with Spontaneous Common Hepatic Duct Perforation: A Spectrum of Congenital Biliary Canal Defects? (23343939)
2013
4
Unexpected small bowel polyposis in a man with a choledochal cyst, more than a difficult cannulation. (22906397)
2012
5
Choledochal cyst: presentation of the disease with a case report. (21875424)
2011
6
The effect of laparoscopic excision vs open excision in children with choledochal cyst: a midterm follow-up study. (21496534)
2011
7
Adenomyoma of common bile duct arising in a type I choledochal cyst. (21623092)
2011
8
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
9
Type IV A choledochal cyst with cystic duct cyst. (20590899)
2010
10
Adult type I choledochal cyst resection. (18446417)
2009
11
Choledochal cyst associated with duodenal atresia: case report and review of the literature. (19693517)
2009
12
Choledochal cyst during pregnancy: the patient's first pregnancy was complicated by a congenital anomaly. (19375577)
2009
13
Biliary rhabdomyoscarcoma mimicking choledochal cyst. (19337643)
2009
14
Choledochal cyst as a diagnostic pitfall: a case report. (18194562)
2008
15
Fetal choledochal cyst diagnosed at 22 weeks of gestation by three-dimensional ultrasonography: a case report. (18955804)
2008
16
An adult choledochal cyst--the magnetic resonance cholangiopancreatography findings: report of a case. (18958568)
2008
17
Image of the month. Choledochal cyst, Todani type I. (17938316)
2007
18
Aplasia of the dorsal pancreas and choledochal cyst. (16474976)
2006
19
Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children. (16707978)
2006
20
Type IV-a choledochal cyst--a rare adolescent presentation as acute abdomen. (16909261)
2006
21
Spontaneous rupture of a type IVA choledochal cyst in a young adult during radiological imaging. (16521234)
2006
22
Pancreatitis complicated with dilated choledochal remnant after congenital choledochal cyst excision. (16195912)
2005
23
Traumatic rupture of choledochal cyst in a child. (15750916)
2005
24
Embryonal rhabdomyosarcoma of the common bile duct mimicking choledochal cyst. (15995817)
2005
25
A retrospective study of choledochal cyst: clinical presentation, diagnosis and treatment. (14768797)
2003
26
Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children. (14666479)
2003
27
Massive dilatation of the common bile duct resembling a choledochal cyst. (11963332)
2001
28
Carcinoma of the head of the pancreas after excision of a choledochal cyst. (11379358)
2001
29
Anomalous pancreaticobiliary junction without congenital choledochal cyst. (10419333)
1999
30
Choledochal cyst associated with polycystic kidney disease: report of a case. (10371064)
1999
31
Choledochal cyst in Simpson-Golabi-Behmel syndrome. (10564884)
1999
32
Incomplete pancreas divisum with anomalous choledochopancreatic duct junction with choledochal cyst. (10522863)
1999
33
Choledochal cyst: review of 74 pediatric cases. (9737111)
1998
34
Choledochal cyst with or without biliary atresia in neonates and young infants: US differentiation. (9807575)
1998
35
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
36
Comparison of hepaticoantrostomy and hepaticojejunostomy for biliary reconstruction after resection of a choledochal cyst. (9099644)
1997
37
Early presentation of choledochal cyst transiently obstructed by an inspissated bile plug. (9349790)
1997
38
Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. (8673308)
1996
39
Left hepatic choledochal cyst. (8784414)
1996
40
Early prenatal diagnosis of choledochal cyst. (8938064)
1996
41
Surgical treatment of choledochal cyst in adults: results and long-term follow-up. (9081911)
1996
42
Case report: giant choledochal cyst. (8889964)
1996
43
Choledochal cyst in pregnancy: a therapeutic dilemma. (7670683)
1995
44
Index of suspicion. Case 3. Diagnosis: Choledochal cyst. (7731913)
1995
45
Pancreatitis associated with choledochal cyst and other anomalies in childhood. (7627524)
1995
46
Obliteration of the distal bile duct in the development of congenital choledochal cyst. (7877036)
1994
47
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst. (8405868)
1993
48
Radiological case of the month. Choledochal cyst. (8362794)
1993
49
Choledochal cyst in a neonate. (1601481)
1992
50
Adenocarcinoma of the gallbladder associated with congenital choledochal cyst and anomalous pancreaticobiliary ductal junction. Case report. (1683581)
1991

Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

Search GEO for disease gene expression data for Choledochal Cyst.

Pathways for genes affiliated with Choledochal Cyst

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 31KEGG
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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VIM, DES
2
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.6VIM, DES
39.1NOS2, REG1A
49.0NOS2, PTGS2
58.6NOS2, MMP1, PTGS2
68.6PTGS2, MMP1, NOS2

Compounds for genes affiliated with Choledochal Cyst

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1taurodeoxycholate4610.1SCT, SST
2lafutidine4610.1SST, SCT
3loxiglumide4610.1SCT, SST
4orcein469.9DES, VIM
5s 100469.9VIM, DES
611-deoxy-pge1469.7PTGS2, MMP1
7meloxicam46 1210.6MMP1, PTGS2
82-arachidonoylglycerol46 3010.6VIM, PTGS2
9biotin46 25 1211.6DES, SCT, VIM
10hematoxylin469.5VIM, DES, MMP1
11procollagen469.5DES, VIM, MMP1
12toluidine469.5DES, VIM
13progestin469.5MMP1, VIM, DES
14nimesulide46 1210.5MMP1, PTGS2
15hydrocortisone46 3 62 1212.4SST, MMP1, VIM
16ketorolac46 1210.4NOS2, PTGS2
17prostaglandin f2alpha469.4MMP1, PTGS2, SST
18hyaluronic acid46 2510.3DES, MMP1, VIM
19norepinephrine46 25 1211.3SCT, MMP1, DES, SST
20mafp469.3NOS2, PTGS2
21formaldehyde46 2510.3VIM, DES, MMP1
22sodium azide469.2VIM, MMP1
23estradiol46 25 1211.2DES, MMP1, SCT, VIM
24cyclopentenone469.1NOS2, PTGS2
25lactate469.1MMP1, SST, DES, VIM
26ns 39846 6210.0NOS2, MMP1, PTGS2
27celecoxib46 62 30 52 25 1214.0NOS2, MMP1, PTGS2
28prostaglandin469.0VIM, PTGS2, SCT, MMP1
29pdtc469.0MMP1, NOS2, PTGS2
30egcg468.9NOS2, MMP1, PTGS2
31isoproterenol46 129.8SCT, VIM, NOS2, SST
32herbimycin a46 629.8MMP1, PTGS2, NOS2
33testosterone46 62 25 1211.8SST, DES, MMP1, VIM, SCT
34retinoic acid46 259.8VIM, SCT, DES, MMP1, SST
35curcumin468.6NOS2, PTGS2, MMP1
36actinomycin d468.5NOS2, DES, VIM, PTGS2
37h2o2468.5NOS2, MMP1, VIM, DES
38sb 20358046 629.5NOS2, MMP1, VIM, PTGS2
39acetylcholine46 52 30 25 1212.4NOS2, SST, VIM, DES, SCT
40adenylate468.4NOS2, DES, VIM, SCT, SST
41arginine468.4DES, SCT, VIM, SST, NOS2
42doxorubicin46 52 1210.3SST, MMP1, VIM, NOS2, DES
43pge2468.3SCT, PTGS2, NOS2, SST, MMP1
44serine468.3SCT, VIM, MMP1, DES, REG1A
45indomethacin46 30 62 1211.2PTGS2, SCT, MMP1, VIM, NOS2
46estrogen468.1NOS2, VIM, PTGS2, DES, MMP1
47cycloheximide468.1NOS2, VIM, MMP1, SST, PTGS2
48dexamethasone46 52 30 1211.1NOS2, SST, MMP1, VIM, PTGS2
49vegf467.7SST, MMP1, NOS2, VIM, PTGS2, DES
50genistein46 30 62 3 25 1212.6SST, VIM, PTGS2, NOS2, REG1A, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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17Gene Ontology
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Cellular components related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7SST, REG1A, MMP1, SCT

Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6VIM, DES

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet