MCID: CHL052
MIFTS: 46

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Choledochal Cyst

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63Wikipedia, 32MalaCards
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Wikipedia:63 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and cholangiocarcinoma. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF-mediated glucocorticoid regulation. The compounds indomethacin and nimesulide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Choledochal Cyst

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

choledochal cyst 8
cystic dilatation of common bile duct 60
congenital choledochal cyst 8


External Ids:

Disease Ontology8 DOID:899
NCIt39 C2943
SNOMED-CT56 398197009, 30533003
MeSH34 D015529
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Clinical Features for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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32MalaCards
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MalaCards organs/tissues related to Choledochal Cyst:

32
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choledochal Cyst:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4REG1A, DES, SCT, CCS
2MP:00053867.9SCT, DES, SST, NOS2, PTGS2, VIM

Publications for Choledochal Cyst

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50PubMed
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Articles related to Choledochal Cyst:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Metastatic cholangiocarcinoma following choledochal cyst excision: an unusual cause of abdominal pain in a 35-year-old female. (23620626)
2013
2
Education and imaging. Hepatobiliary and pancreatic: cystic bile duct remnant after surgery for a choledochal cyst. (23527761)
2013
3
Choledochal cyst - presentation and treatment in an adult. (24058256)
2013
4
Objective differential characteristics of cystic biliary atresia and choledochal cysts in neonates and young infants: sonographic findings. (22644679)
2012
5
Pancreatic hydatid cyst masquerading as a choledochal cyst. (23164030)
2012
6
Extrapleural solitary fibrous tumor of the bile duct arisen on a choledochal cyst. (23089429)
2012
7
The effect of laparoscopic excision vs open excision in children with choledochal cyst: a midterm follow-up study. (21496534)
2011
8
Massive hydrops of the gallbladder mimicking a choledochal cyst. (21616273)
2011
9
Choledochal cyst in pediatric patients: a 10-year single institution experience. (22292226)
2011
10
Hydatid cyst of head of pancreas mimicking choledochal cyst. (22693192)
2011
11
Choledochal cyst: A review of 79 cases and the role of hepaticodochoduodenostomy. (21731232)
2011
12
Robot-assisted complete excision of choledochal cyst type I, hepaticojejunostomy and extracorporeal Roux-en-y anastomosis: a case report and review literature. (20937150)
2010
13
Choledochal cyst during pregnancy: the patient's first pregnancy was complicated by a congenital anomaly. (19375577)
2009
14
Full-term pregnancies after multiple hepatobiliary operations for choledochal cyst: a case report. (19215566)
2009
15
Utility of positron emission tomography/computed tomography in the detection of malignancy within a choledochal cyst. (19111947)
2009
16
Biliary atresia associated with choledochal cyst. (19661672)
2009
17
Estimation of postoperative fat absorption using the 13C mixed-triglyceride breath test in children with choledochal cyst. (18379820)
2009
18
Spontaneous perforation of choledochal cyst and hyperemesis gravidarum. (18564670)
2008
19
Choledochal cyst disease in children and adults: a 30-year single-institution experience. (18471743)
2008
20
Traumatic rupture of a choledochal cyst masking as a duodenal hematoma. (18797884)
2008
21
Perforated choledochal cyst in a Jehovah's Witness patient. (18178991)
2007
22
Choledochal cyst in an adult. (17617346)
2007
23
Symptoms and surgical management of a distal choledochal cyst in a patient with pancreas divisum: case report and review of the literature. (21487552)
2007
24
Sarcomatoid carcinoma of the pancreas and congenital choledochal cyst. (17140915)
2006
25
Image of the month. Choledochocele type 3 choledochal cyst. (15887098)
2005
26
Duodenogastric reflux following biliary reconstruction after excision of choledochal cyst. (15480709)
2005
27
Choledochal cyst and duodenal atresia: a rare combination of malformations. (15372284)
2004
28
Endoscopic management of choledochal cyst. (14997149)
2004
29
Spontaneous rupture of a choledochal cyst and the role of hepatobiliary scintigraphy. (15166894)
2004
30
Acute recurrent pancreatitis associated with anomalous pancreaticobiliary ductal union and choledochal cyst of mixed type I plus II. (12384769)
2003
31
Early cancer in congenital choledochal cyst. (14746158)
2003
32
Biliary papillomatosis arising in a congenital choledochal cyst: report of a case. (12444445)
2002
33
Biliary peritonitis: a rare presentation of perforated choledochal cyst. (12084957)
2002
34
Antenatal diagnosis of a choledochal cyst. Case management and literature review. (12501550)
2002
35
Left hepatectomy for the choledochal cyst (type IV-A) with intrahepatic stenosis: report of a case. (11941939)
2002
36
Complete laparoscopic management of choledochal cyst: report of two cases. (12184910)
2002
37
Choledochal cyst associated with HIV (human immunodeficiency virus) disease. (12808773)
2001
38
Choledochal cyst in infancy: a follow-up study. (10910553)
2000
39
Choledochal cyst associated the with anomalous union of pancreaticobiliary duct (AUPBD) has a more grave clinical course than choledochal cyst alone. (10461418)
1999
40
Pancreaticobiliary carcinoma associated with a large choledochal cyst: role of MRI and MR cholangiopancreatography in diagnosis and preoperative assessment. (10227896)
1999
41
Choledochal cyst in adults. (9830548)
1998
42
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
43
Early presentation of choledochal cyst transiently obstructed by an inspissated bile plug. (9349790)
1997
44
Successful management of ruptured choledochal cyst by primary cyst excision and biliary reconstruction. (9349779)
1997
45
Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. (8673308)
1996
46
Case report: giant choledochal cyst. (8889964)
1996
47
Choledochal cyst in the adult. (7639580)
1995
48
Choledochal cyst. (1582241)
1992
49
Choledochal cyst: Case report and review of literature. (17590797)
1991
50
Cancer arising in a choledochal cyst in a 12-year-old girl. (2286901)
1990

Genetic Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

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Pathways for genes affiliated with Choledochal Cyst

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PTGS2, NOS2
28.9PTGS2, NOS2, MMP1

Compounds for genes affiliated with Choledochal Cyst

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.6SCT
2nimesulide44 1111.3MMP1
3dexamethasone44 49 28 1113.3PTGS2
4taurodeoxycholate4410.3SST, SCT
5lafutidine4410.2SST, SCT
6loxiglumide4410.2SCT, SST
7norepinephrine44 11 2412.1MMP1, DES
8orcein4410.0VIM, DES
9estradiol44 11 2412.0DES, VIM
10s 1004410.0DES, VIM
11pge2449.9SST, PTGS2
12toluidine449.9DES, VIM
13sodium azide449.8MMP1, VIM
14reticulin449.8VIM, DES
1511-deoxy-pge1449.8MMP1, PTGS2
16acetylcholine44 49 28 11 2413.8SCT, NOS2, SST
17meloxicam44 1110.8MMP1, PTGS2
18ketorolac44 1110.8NOS2, PTGS2
19prostaglandin449.7SCT, VIM, MMP1
202-arachidonoylglycerol44 2810.7VIM, PTGS2
21biotin44 11 2411.7VIM, DES, SCT
22mafp449.7NOS2, PTGS2
23mucicarmine449.6DES, VIM
24hematoxylin449.6DES, MMP1, VIM
25progestin449.6DES, VIM, MMP1
26cyclopentenone449.6PTGS2, NOS2
27hydrocortisone44 2 59 1112.6VIM, SST, MMP1
28prostaglandin f2alpha449.5PTGS2, MMP1, SST
29ns 39844 5910.4MMP1, NOS2, PTGS2
30trypsinogen449.4SCT, REG1A
31hyaluronic acid44 2410.3DES, MMP1, VIM
32celecoxib44 59 28 49 11 2414.3PTGS2, MMP1, NOS2
33pdtc449.3PTGS2, NOS2, MMP1
34formaldehyde44 2410.3DES, MMP1, VIM
35isoproterenol44 1110.3NOS2, VIM, SCT, SST
36lactate449.2SST, MMP1, DES, VIM
37clodronate44 49 1111.1PTGS2, MMP1
38herbimycin a44 5910.1NOS2, PTGS2, MMP1
39testosterone44 59 11 2412.0VIM, SCT, DES, SST, MMP1
40adenylate448.9NOS2, DES, SCT, VIM, SST
41retinoic acid44 249.9VIM, SCT, MMP1, DES, SST
42sb 20358044 599.9MMP1, VIM, PTGS2, NOS2
43cysteine448.9CCS, MMP1, DES, SCT, VIM
44actinomycin d448.9PTGS2, VIM, NOS2, DES
45arginine448.9VIM, SCT, NOS2, DES, SST
46curcumin448.8MMP1, PTGS2, NOS2
47doxorubicin44 49 1110.8VIM, SST, DES, NOS2, MMP1
48estrogen448.4NOS2, DES, VIM, PTGS2, MMP1
49vegf448.2VIM, SST, MMP1, NOS2, PTGS2, DES
50genistein44 28 59 2 11 2412.8NOS2, PTGS2, REG1A, SST, VIM, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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16Gene Ontology
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Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide metabolic processGO:0068019.6NOS2, CCS

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet