MCID: CHL052
MIFTS: 50

Choledochal Cyst malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Choledochal Cyst

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65Wikipedia, 33MalaCards
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Wikipedia:65 Choledochal cysts (aka bile duct cyst) are congenital conditions involving cystic dilatation of bile... more...

MalaCards: Choledochal Cyst, also known as cystic dilatation of common bile duct, is related to pancreatitis and cholangiocarcinoma. An important gene associated with Choledochal Cyst is SCT (secretin), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds taurodeoxycholate and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are muscle and nervous system.

Aliases & Classifications for Choledochal Cyst

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

choledochal cyst 8
cystic dilatation of common bile duct 62
congenital choledochal cyst 8


External Ids:

Disease Ontology8 DOID:899
NCIt40 C2943
SNOMED-CT58 398197009, 30533003
MeSH35 D015529
ICD1025 Q44.4

Related Diseases for Choledochal Cyst

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Choledochal Cyst:



Diseases related to choledochal cyst

Symptoms for Choledochal Cyst

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Drugs & Therapeutics for Choledochal Cyst

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Choledochal Cyst

Genetic Tests for Choledochal Cyst

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Anatomical Context for Choledochal Cyst

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33MalaCards
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MalaCards organs/tissues related to Choledochal Cyst:

33
Pancreas, Liver, Colon, Kidney, Heart, Testes, Appendix

Animal Models for Choledochal Cyst or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Choledochal Cyst:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0DES, PTGS2, VIM, NOS2
2MP:00036317.8NOS2, SST, VIM, PTGS2, SCT
3MP:00053867.4DES, SCT, PTGS2, VIM, SST, NOS2
4MP:00053877.3PTGS2, VIM, MMP1, SST, NOS2
5MP:00053766.5NOS2, DES, SCT, PTGS2, VIM, MMP1

Publications for Choledochal Cyst

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52PubMed
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Articles related to Choledochal Cyst:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Laparoscopic resection of choledochal cyst: report of a case. (23657070)
2013
2
Early experience of laparoscopic choledochal cyst excision in children. (24266013)
2013
3
Intact Choledochal Cyst with Spontaneous Common Hepatic Duct Perforation: A Spectrum of Congenital Biliary Canal Defects? (23343939)
2013
4
Unexpected small bowel polyposis in a man with a choledochal cyst, more than a difficult cannulation. (22906397)
2012
5
Choledochal cyst: presentation of the disease with a case report. (21875424)
2011
6
The effect of laparoscopic excision vs open excision in children with choledochal cyst: a midterm follow-up study. (21496534)
2011
7
Adenomyoma of common bile duct arising in a type I choledochal cyst. (21623092)
2011
8
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
9
Type IV A choledochal cyst with cystic duct cyst. (20590899)
2010
10
Adult type I choledochal cyst resection. (18446417)
2009
11
Choledochal cyst associated with duodenal atresia: case report and review of the literature. (19693517)
2009
12
Choledochal cyst during pregnancy: the patient's first pregnancy was complicated by a congenital anomaly. (19375577)
2009
13
Biliary rhabdomyoscarcoma mimicking choledochal cyst. (19337643)
2009
14
Choledochal cyst as a diagnostic pitfall: a case report. (18194562)
2008
15
Fetal choledochal cyst diagnosed at 22 weeks of gestation by three-dimensional ultrasonography: a case report. (18955804)
2008
16
An adult choledochal cyst--the magnetic resonance cholangiopancreatography findings: report of a case. (18958568)
2008
17
Image of the month. Choledochal cyst, Todani type I. (17938316)
2007
18
Aplasia of the dorsal pancreas and choledochal cyst. (16474976)
2006
19
Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children. (16707978)
2006
20
Type IV-a choledochal cyst--a rare adolescent presentation as acute abdomen. (16909261)
2006
21
Spontaneous rupture of a type IVA choledochal cyst in a young adult during radiological imaging. (16521234)
2006
22
Pancreatitis complicated with dilated choledochal remnant after congenital choledochal cyst excision. (16195912)
2005
23
Traumatic rupture of choledochal cyst in a child. (15750916)
2005
24
Embryonal rhabdomyosarcoma of the common bile duct mimicking choledochal cyst. (15995817)
2005
25
A retrospective study of choledochal cyst: clinical presentation, diagnosis and treatment. (14768797)
2003
26
Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children. (14666479)
2003
27
Massive dilatation of the common bile duct resembling a choledochal cyst. (11963332)
2001
28
Carcinoma of the head of the pancreas after excision of a choledochal cyst. (11379358)
2001
29
Anomalous pancreaticobiliary junction without congenital choledochal cyst. (10419333)
1999
30
Choledochal cyst associated with polycystic kidney disease: report of a case. (10371064)
1999
31
Choledochal cyst in Simpson-Golabi-Behmel syndrome. (10564884)
1999
32
Incomplete pancreas divisum with anomalous choledochopancreatic duct junction with choledochal cyst. (10522863)
1999
33
Choledochal cyst: review of 74 pediatric cases. (9737111)
1998
34
Choledochal cyst with or without biliary atresia in neonates and young infants: US differentiation. (9807575)
1998
35
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
36
Comparison of hepaticoantrostomy and hepaticojejunostomy for biliary reconstruction after resection of a choledochal cyst. (9099644)
1997
37
Early presentation of choledochal cyst transiently obstructed by an inspissated bile plug. (9349790)
1997
38
Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. (8673308)
1996
39
Left hepatic choledochal cyst. (8784414)
1996
40
Early prenatal diagnosis of choledochal cyst. (8938064)
1996
41
Surgical treatment of choledochal cyst in adults: results and long-term follow-up. (9081911)
1996
42
Case report: giant choledochal cyst. (8889964)
1996
43
Choledochal cyst in pregnancy: a therapeutic dilemma. (7670683)
1995
44
Index of suspicion. Case 3. Diagnosis: Choledochal cyst. (7731913)
1995
45
Pancreatitis associated with choledochal cyst and other anomalies in childhood. (7627524)
1995
46
Obliteration of the distal bile duct in the development of congenital choledochal cyst. (7877036)
1994
47
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst. (8405868)
1993
48
Radiological case of the month. Choledochal cyst. (8362794)
1993
49
Choledochal cyst in a neonate. (1601481)
1992
50
Adenocarcinoma of the gallbladder associated with congenital choledochal cyst and anomalous pancreaticobiliary ductal junction. Case report. (1683581)
1991

Variations for Choledochal Cyst

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Expression for genes affiliated with Choledochal Cyst

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledochal Cyst

Search GEO for disease gene expression data for Choledochal Cyst.

Pathways for genes affiliated with Choledochal Cyst

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 30KEGG
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Pathways related to Choledochal Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VIM, DES
2
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.6VIM, DES
39.1NOS2, REG1A
49.0NOS2, PTGS2
58.6NOS2, MMP1, PTGS2
68.6PTGS2, MMP1, NOS2

Compounds for genes affiliated with Choledochal Cyst

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Choledochal Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1taurodeoxycholate4510.1SCT, SST
2lafutidine4510.1SST, SCT
3loxiglumide4510.1SCT, SST
4orcein459.9DES, VIM
5s 100459.9VIM, DES
611-deoxy-pge1459.7PTGS2, MMP1
7meloxicam45 1110.6MMP1, PTGS2
82-arachidonoylglycerol45 2910.6VIM, PTGS2
9biotin45 24 1111.6DES, SCT, VIM
10hematoxylin459.5VIM, DES, MMP1
11procollagen459.5DES, VIM, MMP1
12toluidine459.5DES, VIM
13progestin459.5MMP1, VIM, DES
14nimesulide45 1110.5MMP1, PTGS2
15hydrocortisone45 3 61 1112.4SST, MMP1, VIM
16ketorolac45 1110.4NOS2, PTGS2
17prostaglandin f2alpha459.4MMP1, PTGS2, SST
18hyaluronic acid45 2410.3DES, MMP1, VIM
19norepinephrine45 24 1111.3SCT, MMP1, DES, SST
20mafp459.3NOS2, PTGS2
21formaldehyde45 2410.3VIM, DES, MMP1
22sodium azide459.2VIM, MMP1
23estradiol45 24 1111.2DES, MMP1, SCT, VIM
24cyclopentenone459.1NOS2, PTGS2
25lactate459.1MMP1, SST, DES, VIM
26ns 39845 6110.0NOS2, MMP1, PTGS2
27celecoxib45 61 29 51 24 1114.0NOS2, MMP1, PTGS2
28prostaglandin459.0VIM, PTGS2, SCT, MMP1
29pdtc459.0MMP1, NOS2, PTGS2
30egcg458.9NOS2, MMP1, PTGS2
31isoproterenol45 119.8SCT, VIM, NOS2, SST
32herbimycin a45 619.8MMP1, PTGS2, NOS2
33testosterone45 61 24 1111.8SST, DES, MMP1, VIM, SCT
34retinoic acid45 249.8VIM, SCT, DES, MMP1, SST
35curcumin458.6NOS2, PTGS2, MMP1
36actinomycin d458.5NOS2, DES, VIM, PTGS2
37h2o2458.5NOS2, MMP1, VIM, DES
38sb 20358045 619.5NOS2, MMP1, VIM, PTGS2
39acetylcholine45 51 29 24 1112.4NOS2, SST, VIM, DES, SCT
40adenylate458.4NOS2, DES, VIM, SCT, SST
41arginine458.4DES, SCT, VIM, SST, NOS2
42doxorubicin45 51 1110.3SST, MMP1, VIM, NOS2, DES
43pge2458.3SCT, PTGS2, NOS2, SST, MMP1
44serine458.3SCT, VIM, MMP1, DES, REG1A
45indomethacin45 29 61 1111.2PTGS2, SCT, MMP1, VIM, NOS2
46estrogen458.1NOS2, VIM, PTGS2, DES, MMP1
47cycloheximide458.1NOS2, VIM, MMP1, SST, PTGS2
48dexamethasone45 51 29 1111.1NOS2, SST, MMP1, VIM, PTGS2
49vegf457.7SST, MMP1, NOS2, VIM, PTGS2, DES
50genistein45 29 61 3 24 1112.6SST, VIM, PTGS2, NOS2, REG1A, MMP1

GO Terms for genes affiliated with Choledochal Cyst

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16Gene Ontology
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Cellular components related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7SST, REG1A, MMP1, SCT

Biological processes related to Choledochal Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6VIM, DES

Products for genes affiliated with Choledochal Cyst

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Sources for Choledochal Cyst

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet