MCID: CHL039
MIFTS: 40

Choledocholithiasis malady

Summaries for Choledocholithiasis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A gallstone is a crystalline concretion formed within the gallbladder by accretion of bile components.... more...

MalaCards: Choledocholithiasis is related to cholelithiasis and acute pancreatitis. An important gene associated with Choledocholithiasis is GUSB (glucuronidase, beta), and among its related pathways are Selenium Pathway and NAD metabolism. The compounds heparin and lactulose have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and t cells.

Aliases & Classifications for Choledocholithiasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

choledocholithiasis 8 10 45 61


External Ids:

Disease Ontology8 DOID:11755
MeSH35 D042883

Related Diseases for Choledocholithiasis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1cholelithiasis30.8GUSB, ABCB4, ALPPL2, ALPP, ALPL, GGT1
2acute pancreatitis30.1SLC17A5, GPT
3sickle cell disease30.1UGT1A1, GUSB
4hepatitis a29.9F2
5obstructive jaundice29.9GGT1, ALPP
6extrahepatic cholestasis29.9GGT1, ALPP
7primary sclerosing cholangitis29.9ABCB4, GPT, GGT1
8intrahepatic cholestasis29.8ABCB4, SLC17A5, GGT1, ALPP
9hepatitis c29.8GGT1, F2, GPT, ABCB4, SLC17A5
10portal hypertension29.8SLC17A5, GGT1, F2, ALB, GPT
11cholecystolithiasis10.4
12acute cholangitis10.4
13ascariasis10.1
14bacteremia10.1
15schistosomiasis10.0GUSB
16hepatitis e10.0GPT
17gallbladder disease10.0GGT1
18coronary heart disease10.0GGT1
19ovarian cancer10.0GUSB
20hydrops fetalis10.0GUSB
21glucose intolerance10.0GPT
22rheumatoid arthritis10.0GUSB
23alcohol dependence10.0GGT1
24cryoglobulinemia10.0SLC17A5
25substance abuse10.0GGT1
26sarcoma10.0GUSB
27thalassemia10.0UGT1A1
28biliary atresia10.0GPT, GGT1
29stomach cancer10.0GUSB
30wilson disease10.0SLC17A5, GPT
31scrub typhus10.0GPT, SLC17A5
32pyridoxine deficiency10.0SLC17A5, GPT
33pancreatic cancer10.0GUSB, GGT1
34neonatal hemochromatosis10.0GGT1, SLC17A5
35dysgerminoma10.0ALPP
36hepatitis10.0GPT, SLC17A5
37opisthorchiasis10.0GGT1
38hellp syndrome10.0SLC17A5, GPT
39arthropathy10.0ALPL
40adenoma10.0GGT1
41respiratory failure10.0ALPL
42hyperuricemia10.0GGT1, GPT
43hypercholesterolemia10.0SLC17A5, GGT1, GPT
44crigler-najjar syndrome10.0UGT1A1
45thromboembolism10.0F2
46gingivitis10.0ALPP, GUSB
47obesity10.0SLC17A5, GGT1, GPT
48neutropenia10.0UGT1A1, GPT
49primary hyperoxaluria10.0GGT1
50cholestasis, progressive familial intrahepatic 110.0ABCB4, GGT1

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to choledocholithiasis

Clinical Features for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Choledocholithiasis

Drug clinical trials:

Search ClinicalTrials for Choledocholithiasis

Search NIH Clinical Center for Choledocholithiasis

Search CenterWatch for Choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

Sources:
33MalaCards
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MalaCards organs/tissues related to Choledocholithiasis:

33
Liver, Heart, T cells

Animal Models for Choledocholithiasis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Choledocholithiasis

Sources:
51PubMed
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Articles related to Choledocholithiasis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
ERCP can be safely and effectively performed by a pediatric gastroenterologist for choledocholithiasis in a pediatric facility. (24048163)
2013
2
Endoscopic retrograde cholangiopancreatography for suspected choledocholithiasis: testing the current guidelines. (23540659)
2013
3
Operative management of recurrent choledocholithiasis. (22907776)
2012
4
Endoscopic papillary balloon dilatation versus endoscopic sphincterotomy in the treatment for choledocholithiasis: a meta-analysis. (21913984)
2012
5
Endoscopic papillary balloon dilation for removal of choledocholithiasis: indications, advantages, complications, and long-term follow-up results. (21461066)
2011
6
Two-port laparoscopic common bile duct exploration with T-tube choledochostomy for management of choledocholithiasis: an initial clinical report. (21679549)
2011
7
Role of endoscopic ultrasound/SpyScope in diagnosis and treatment of choledocholithiasis in pregnancy. (20653072)
2010
8
Transcylindrical gas-free cholecystectomy for the treatment of cholelithiasis, cholecystitis, and choledocholithiasis. (20354871)
2010
9
Choledocholithiasis: endotherapy versus surgery. (20718313)
2010
10
A same day approach for choledocholithiasis using endoscopic stone removal followed by laparoscopic cholecystectomy: a retrospective study. (19260236)
2009
11
Single session versus separate session endoscopic ultrasonography plus endoscopic retrograde cholangiography in patients with low to moderate risk for choledocholithiasis. (19638088)
2009
12
Preoperative diagnosis of choledocholithiasis: the role of MRCP. (19516211)
2009
13
Liver test patterns in patients with acute calculous cholecystitis and/or choledocholithiasis. (19210291)
2009
14
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism is associated with choledocholithiasis in Taiwanese patients. (19486253)
2009
15
Duodenal impaction/perforation of a biliary stent--a rare complication in the management of choledocholithiasis. (19795045)
2009
16
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. (18570948)
2008
17
Effect of Lidan Granule on bile lithogenesis in patients with choledocholithiasis combined with cholecystolithiasis. (18679607)
2008
18
EUS: a meta-analysis of test performance in suspected choledocholithiasis. (18226685)
2008
19
Multiple primary choledocholithiasis in sickle cell disease. (19075544)
2008
20
Laparoscopic choledochotomy in management of choledocholithiasis. (17710045)
2007
21
Endoscopic management of symptomatic choledocholithiasis in pregnancy without the use of radiations. (18074941)
2007
22
Cholelithiasis and choledocholithiasis associated with anomalous junction of the cystic duct in a child. (17923183)
2007
23
Choledocholithiasis mimicking sphincter of oddi dysfunction. (21960883)
2007
24
Surgical clip migration and choledocholithiasis: a late, abrupt complication of laparoscopic cholecystectomy. (17687655)
2007
25
Accuracy of computed tomographic intravenous cholangiography (CT-IVC) with iotroxate in the detection of choledocholithiasis. (15627178)
2005
26
Choledocholithiasis. (16125593)
2005
27
Microbiology of choledochal bile in patients with choledocholithiasis admitted to a tertiary hospital. (12603536)
2003
28
Magnetic resonance cholangiopancreatography versus endoscopic retrograde cholangiopancreatography in the diagnosis of choledocholithiasis. (12811312)
2003
29
Contrast-enhanced helical CT of choledocholithiasis. (12818842)
2003
30
Do patients with recurrent choledocholithiasis after endoscopic sphincterotomy benefit from regular follow-up? (11923765)
2002
31
Elevated carbohydrate antigen 19-9 levels in a patient with choledocholithiasis. (16378308)
2002
32
Choledocholithiasis in the Setting of Portal Hypertension. (11469971)
2001
33
Choledocholithiasis: new approach to an old problem. (11596888)
2001
34
Recognition of ERC-induced pancreatitis in patients with choledocholithiasis by an analysis of laboratory findings. (10791235)
2000
35
Detection of choledocholithiasis with MR cholangiography: comparison of three-dimensional fast spin-echo and single- and multisection half-Fourier rapid acquisition with relaxation enhancement sequences. (10831692)
2000
36
Treatment of choledocholithiasis: therapeutic ERCP versus peroperative extraction during laparoscopic cholecystectomy. (11189996)
2000
37
Diagnosis of choledocholithiasis: EUS or magnetic resonance cholangiography? A prospective controlled study. (9869719)
1999
38
Choledocholithiasis at the hepatic confluence mimicking a hilar cholangiocarcinoma. (9951919)
1998
39
Long-term complications of endoscopic biliary sphincterotomy for choledocholithiasis. (9831850)
1998
40
Choledocholithiasis: percutaneous treatment. (9828723)
1998
41
Endoscopic sphincterotomy and laparoscopic cholecystectomy in an infant with cholecysto-choledocholithiasis. (9722013)
1998
42
Gallbladder motility and lithogenicity of bile in patients with choledocholithiasis after endoscopic sphincterotomy. (9210617)
1997
43
Management of choledocholithiasis in the time of laparoscopic cholecystectomy. (9240956)
1997
44
Endoscopic retrograde cholangiopancreatography (ERCP) for symptomatic choledocholithiasis during pregnancy. (17377439)
1997
45
Endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy for symptomatic choledocholithiasis after recent myocardial infarction. (8792707)
1996
46
Management of choledocholithiasis encountered during laparoscopic cholecystectomy. (8600842)
1996
47
Managing choledocholithiasis in the laparoscopic era. (7492013)
1995
48
Role of open choledochotomy in the treatment of choledocholithiasis. (8480887)
1993
49
Bile duct carcinoma simulating choledocholithiasis. (2304664)
1990
50
Endoscopic sphincterotomy in acute cholangitis due to choledocholithiasis. (2341115)
1990

Genetic Variations for Choledocholithiasis

Expression for genes affiliated with Choledocholithiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for genes affiliated with Choledocholithiasis

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Choledocholithiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ALB, GGT1, F2
2
NAD metabolism
Hide members
8.9ALPPL2, ALPP, ALPL
38.9ALPL, ALPP, ALPPL2
4
Hide members
6.7ELOVL6, GPT, ABCB4, PNLIPRP1, GGT1, ALPL

Compounds for genes affiliated with Choledocholithiasis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Choledocholithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1heparin45 29 11 2413.4GUSB
2lactulose4510.2GUSB, GPT, SLC17A5
3glycyrrhizin45 2911.1GUSB, GPT, SLC17A5
4glycocholate4510.1SLC17A5, ABCB4, GPT, GUSB
5gamma globulin4510.0SLC17A5, GGT1, ALB
6ethyl glucuronide45 2411.0GGT1, UGT1A1, GUSB
7nash4510.0GGT1, GPT, SLC17A5
8d-glucaric acid4510.0GGT1, GUSB
9hepaplastin459.9ALB, SLC17A5, GPT, F2
10nevirapine45 50 1111.9SLC17A5, GGT1, GPT
11aminopyrine459.9SLC17A5, F2, GPT, GGT1
12zidovudine45 1110.8GPT, ALB, SLC17A5, GUSB
13buprenorphine45 29 1111.8GUSB, UGT1A1, SLC17A5
14rifampicin45 29 6011.8GGT1, SLC17A5, GPT, UGT1A1
15mycophenolate mofetil45 50 1111.8UGT1A1, GGT1, GPT, ALB
16naltrexone45 50 29 1112.8SLC17A5, GGT1, UGT1A1
17opium459.8GUSB, SLC17A5
18antipyrine45 1110.7ALB, GGT1, SLC17A5, F2, GUSB
19acetaminophen45 2 50 11 2413.6F2, GGT1, SLC17A5, UGT1A1, GPT
20valproic acid45 50 11 2412.6ALB, GGT1, SLC17A5, GPT, UGT1A1
21tacrolimus45 50 1111.5GGT1, SLC17A5, GPT, ABCB4, ALB
22hyaluronic acid45 2410.5GGT1, GPT, F2, SLC17A5, ALB
23silymarin459.5GPT, F2, GUSB, UGT1A1, GGT1, SLC17A5
24methotrexate45 50 1111.4ABCB4, SLC17A5, F2, GGT1, ALB, GPT
25vitamin b6459.3SLC17A5, ALB, ALPP, ALPL
267,8-dihydroneopterin45 2410.3ALPP, ALPPL2, ALPL
27dihydroneopterin triphosphate45 2410.2ALPP, ALPL, ALPPL2
28dihydroxyacetone45 2410.2ALPP, ALPL, ALPPL2
29pge1459.2GPT, ALPP, SLC17A5, F2, GUSB
30ethanol45 50 11 2412.1ALPL, GGT1, SLC17A5, GPT, GUSB, ALPPL2
31bezafibrate45 29 1111.1ALPP, GPT, GGT1, ABCB4, SLC17A5
32sevoflurane45 1110.1GGT1, ALPP, GPT, SLC17A5, ALB
33isoflurane45 1110.1ALB, ALPP, GGT1, SLC17A5, GPT
34phosphorus459.1SLC17A5, GPT, GGT1, ALPP, ALB
35verapamil45 50 29 11 2413.1ABCB4, ALPP, GGT1, SLC17A5, GPT
36levamisole45 1110.1ALPP, ALPL, ALPPL2
37polyethylene glycol459.1F2, SLC17A5, ALPP, ALB
38simvastatin45 50 60 29 11 2414.1ALPP, SLC17A5, F2, UGT1A1, GPT
39phenytoin45 50 29 1112.0ALB, ALPP, UGT1A1, GGT1, SLC17A5
40phenobarbital45 29 1110.9UGT1A1, SLC17A5, GUSB, ALPP, GGT1, GPT
41vitamin b12458.9GUSB, GGT1, ALPP, SLC17A5, GPT, ALB
42ursodeoxycholic acid45 11 2410.9ABCB4, GPT, F2, SLC17A5, GGT1, ALPP
43pyridoxal 5-phosphate458.9GPT, SLC17A5, GGT1, ALPL, ALPP, ALB
44thyroxine45 249.8UGT1A1, GPT, SLC17A5, GGT1, ALB, ALPP
45lactate458.6SLC17A5, ALB, ALPP, GGT1, F2, GPT
46creatinine458.6ALB, GGT1, SLC17A5, F2, ALPP, GPT
47tamoxifen45 50 29 1111.5F2, ALPP, SLC17A5, GGT1, UGT1A1
48cholesterol45 29 11 2411.5SLC17A5, ALB, UGT1A1, GPT, ABCB4, ALPP
49alanine458.3UGT1A1, GPT, ALB, F2, SLC17A5, ABCB4
50aspartate457.9SLC17A5, GUSB, ALB, ALPP, ALPL, GGT1

GO Terms for genes affiliated with Choledocholithiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:0312258.9ALPPL2, ALPP, ALPL
2extracellular spaceGO:0056158.1ALB, ALPL, LGI1, PNLIPRP1, F2, CTRB1

Biological processes related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1ELOVL6, ALB, GGT1, ABCB4, GPT, UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040358.9ALPPL2, ALPP, ALPL

Products for genes affiliated with Choledocholithiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Choledocholithiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet