MCID: CHL039
MIFTS: 45

Choledocholithiasis malady

Summaries for Choledocholithiasis

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MalaCards based summary: Choledocholithiasis is related to cholelithiasis and cholecystitis. An important gene associated with Choledocholithiasis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Selenium Pathway and Fatty acid, triacylglycerol, and ketone body metabolism. The compounds lactulose and glycocholate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are reproductive system and homeostasis/metabolism.

Aliases & Classifications for Choledocholithiasis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH
See all sources

Choledocholithiasis, Aliases & Descriptions:

Name: Choledocholithiasis 10 12 45 62


External Ids:

Disease Ontology10 DOID:11755
MeSH35 D042883

Related Diseases for Choledocholithiasis

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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1cholelithiasis30.9GGT1, ALPP, ALPL, ALPPL2, GUSB, GPT
2cholecystitis30.7GPT, ELOVL6
3cholangitis30.7SLC17A5, GGT1, ALPP, ALPL, ALPPL2, ALB
4pancreatitis30.6ABCB4, ALB, ALPPL2, ALPL, ALPP, GGT1
5cholangiocarcinoma30.3ALPPL2, ALPL, ALPP, GGT1
6hepatitis30.3F2, UGT1A1, GPT, GUSB, ALPP, GGT1
7liver cirrhosis30.2F2, GPT, GUSB, ALB, GGT1, SLC17A5
8cholestasis30.1GGT1, ALPP, ALPL, ALPPL2, ALB, GPT
9obstructive jaundice30.0ALPP, GGT1
10extrahepatic cholestasis30.0ALPP, GGT1
11intrahepatic cholestasis29.9ABCB4, ALPP, GGT1, SLC17A5
12hepatocellular carcinoma29.9F2, ABCB4, UGT1A1, GPT, ALB, ALPPL2
13portal hypertension29.9F2, GPT, ALB, GGT1, SLC17A5
14cholecystolithiasis10.4
15acute cholangitis10.3
16duodenitis10.3
17bacteremia10.1
18ascariasis10.1
19sickle cell disease10.1
20gallbladder disease10.1GGT1
21hydrops fetalis10.1GUSB
22hepatitis e10.1GPT
23opisthorchiasis10.1GGT1
24crigler-najjar syndrome, type i10.1UGT1A1
25scrub typhus10.1SLC17A5, GPT
26pyridoxine deficiency10.0GPT, SLC17A5
27neonatal hemochromatosis10.0GGT1, SLC17A5
28hellp syndrome10.0GPT, SLC17A5
29neonatal jaundice10.0UGT1A1, GUSB
30cholestasis, progressive familial intrahepatic 110.0GGT1, ABCB4
31alcohol abuse10.0GPT, GGT1, SLC17A5
32hepatitis a10.0F2
33germ cell cancer10.0ALPPL2, ALPP
34endodermal sinus tumor10.0ALPPL2, ALPP
35biliary atresia10.0GGT1, GPT
36hypophosphatasia, infantile10.0ALPP, ALPL
37fascioliasis10.0ALPP, GGT1, SLC17A5
38familial hyperlipidemia10.0GPT, GGT1, SLC17A5
39splenomegaly10.0GPT, SLC17A5
40alcohol dependence10.0GPT, GGT1, SLC17A5
41hypercholesterolemia, familial10.0SLC17A5, GGT1, GPT
42periodontal disease10.0SLC17A5, ALPP, GUSB
43gonadoblastoma10.0ALPP, ALPPL2
44gingivitis10.0GUSB, ALPP
45dysfibrinogenemia10.0F2
46cholangitis, primary sclerosing10.0ABCB4, GPT, GGT1
47wilson disease10.0GPT, SLC17A5
48rickets10.0ALB, ALPP
49factor vii deficiency10.0F2
50kernicterus10.0ALB, UGT1A1

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to choledocholithiasis

Symptoms for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

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Drug clinical trials:

Search ClinicalTrials for Choledocholithiasis

Search NIH Clinical Center for Choledocholithiasis

Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

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MalaCards organs/tissues related to Choledocholithiasis:

33
Liver, Testes, Heart

Animal Models for Choledocholithiasis or affiliated genes

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MGI Mouse Phenotypes related to Choledocholithiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2GGT1, ALPP, ALPL, GUSB, ABCB4, F2
2MP:00053767.1SLC17A5, F2, ABCB4, GUSB, ELOVL6, ALB

Publications for Choledocholithiasis

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Articles related to Choledocholithiasis:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Endoscopic Sphincterotomy Using the Rendezvous Technique for Choledocholithiasis during Laparoscopic Cholecystectomy: A Case Report. (25298761)
2014
2
Magnetic resonance cholangiopancreatography: utilization and usefulness in suspected choledocholithiasis. (25267497)
2014
3
Endoscopic papillary large balloon dilatation alone is safe and effective for the treatment of difficult choledocholithiasis in cases of Billroth II gastrectomy: a single center experience. (23392745)
2013
4
Non-invasive assessment of choledocholithiasis in patients with gallstones and abnormal liver function. (24124333)
2013
5
Consecutive versus separate sessions of endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for symptomatic choledocholithiasis. (23389062)
2013
6
Successful single-session endosonography-based endoscopic retrograde cholangiopancreatography without fluoroscopy in pregnant patients with suspected choledocholithiasis: a case series. (23798477)
2013
7
Endoscopic papillary balloon dilation for a 7-year-old girl with choledocholithiasis. (23679173)
2013
8
Risk factors of choledocholithiasis formation after liver transplantation. (23558078)
2013
9
Choledocholithiasis presenting with very high transaminase level. (23188856)
2012
10
Endoscopic treatment of difficult choledocholithiasis. (22709458)
2012
11
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
12
Endoscopic papillary balloon dilation for removal of choledocholithiasis: indications, advantages, complications, and long-term follow-up results. (21461066)
2011
13
Choledocholithiasis management in rural America: health disparity or health opportunity? (21571311)
2011
14
Laparoscopic exploration of the common bile duct with a rigid scope in patients with problematic choledocholithiasis. (20354699)
2010
15
Successful endoscopic extraction of a large impacted choledocholithiasis in the ampulla of vater: two interesting cases. (20590755)
2010
16
Extraction of surgical clip-induced "lollipop" choledocholithiasis. (20072999)
2010
17
A same day approach for choledocholithiasis using endoscopic stone removal followed by laparoscopic cholecystectomy: a retrospective study. (19260236)
2009
18
Single session versus separate session endoscopic ultrasonography plus endoscopic retrograde cholangiography in patients with low to moderate risk for choledocholithiasis. (19638088)
2009
19
Preoperative diagnosis of choledocholithiasis: the role of MRCP. (19516211)
2009
20
Liver test patterns in patients with acute calculous cholecystitis and/or choledocholithiasis. (19210291)
2009
21
Long-term complications of endoscopic biliary sphincterotomy for choledocholithiasis: a North-American perspective. (19888258)
2009
22
Patients with bulbar papilla and choledocholithiasis and their endoscopic management. (19453023)
2009
23
Management of choledocholithiasis in patients undergoing cholecystectomy. (19566539)
2009
24
Management of preoperatively suspected choledocholithiasis: a decision analysis. (18683008)
2008
25
Laparoendoscopic "rendezvous" versus laparoscopic antegrade sphincterotomy for choledocholithiasis. (18707043)
2008
26
Preoperative clinical and paraclinical predictors of choledocholithiasis. (18522887)
2008
27
Common bile duct thrombi secondary to hepatoma, with biliary invasion mimicking a choledocholithiasis (with video). (17258996)
2007
28
Suspected choledocholithiasis: endoscopic ultrasound or magnetic resonance cholangio-pancreatography? A systematic review. (18049172)
2007
29
Laparoscopic management of difficult recurrent choledocholithiasis. (17651582)
2007
30
Conversion rate for laparoscopic cholecystectomy after endoscopic retrograde cholangiography in the treatment of choledocholithiasis: does the time interval matter? (17031740)
2006
31
Outcomes of cholecystectomy after endoscopic sphincterotomy for choledocholithiasis. (16455464)
2006
32
Role of endoscopic retrograde cholangiopancreatography in the management of suspected choledocholithiasis. (12618941)
2003
33
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
34
Recurrence of biliary symptoms after endoscopic sphincterectomy for choledocholithiasis in patients with gallbladder stones. (11911095)
2002
35
Diagnosis of choledocholithiasis and bile duct stenosis by magnetic resonance cholangiogram. (11966585)
2002
36
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
37
Choledocholithiasis in the Setting of Portal Hypertension. (11469971)
2001
38
Over-the-wire US catheter probe as an adjunct to ERCP in the detection of choledocholithiasis. (11726847)
2001
39
Management of choledocholithiasis found during laparoscopic cholecystectomy: a strategy based on the use of postoperative endoscopic retrograde cholangiography and sphincterotomy. (11332046)
2001
40
Choledocholithiasis: endoscopic versus laparoscopic management. (9926747)
1999
41
Eight years' experience with the use of a transcystic common bile duct duodenal double-lumen catheter for the treatment of choledocholithiasis. (9780991)
1998
42
Ofuji's papuloerythroderma following choledocholithiasis with secondary sepsis: complete resolution with surgery. (9692313)
1998
43
Endoscopic ultrasonography for diagnosing choledocholithiasis: a prospective comparative study with ultrasonography and computed tomography. (9040999)
1997
44
Choledocholithiasis and gallstone pancreatitis. (9512804)
1997
45
Biliary stents as temporary treatment for choledocholithiasis in pregnant patients. (9260726)
1997
46
Transduodenal sphincteroplasty in the treatment of choledocholithiasis in pregnancy. (8976069)
1996
47
Endoscopic biliary sphincterotomy and stone extraction in a child with choledocholithiasis complicating Byler's disease. (8985855)
1996
48
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
49
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
50
Laparoscopic cholecystectomy: laboratory predictors of choledocholithiasis. (7944040)
1994

Variations for Choledocholithiasis

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Expression for genes affiliated with Choledocholithiasis

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Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for genes affiliated with Choledocholithiasis

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Compounds for genes affiliated with Choledocholithiasis

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Compounds related to Choledocholithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1lactulose4510.0SLC17A5, GUSB, GPT
2glycocholate459.8GUSB, GPT, ABCB4, SLC17A5
3ethyl glucuronide45 2610.8GGT1, UGT1A1, GUSB
4gamma globulin459.7ALB, GGT1, SLC17A5
5hepaplastin459.7F2, GPT, SLC17A5, ALB
6aminopyrine459.6GPT, F2, SLC17A5, GGT1
7glycyrrhizin45 3010.6GPT, GUSB, SLC17A5
8rifampicin45 30 6111.6SLC17A5, GGT1, GPT, UGT1A1
9zidovudine45 51 1311.5SLC17A5, GPT, GUSB, ALB
10mycophenolate mofetil45 51 1311.5GPT, UGT1A1, ALB, GGT1
11uric acid45 2610.4SLC17A5, GGT1, GPT, ALB
127,8-dihydroneopterin45 2610.4ALPPL2, ALPL, ALPP
13dihydroneopterin triphosphate45 2610.3ALPP, ALPPL2, ALPL
14dihydroxyacetone45 2610.3ALPP, ALPL, ALPPL2
15acetaminophen45 3 51 26 1313.3SLC17A5, GPT, UGT1A1, F2, GGT1
16antipyrine45 1310.3GUSB, ALB, GGT1, SLC17A5, F2
17valproic acid45 51 26 1312.3SLC17A5, GGT1, ALB, GPT, UGT1A1
18vitamin b6459.3ALB, ALPP, SLC17A5, ALPL
194-Nitrophenol269.3ALPP, ALPPL2, ALPL
20nash459.3GPT, SLC17A5, GGT1
21Dihydroxyacetone phosphate269.3ALPL, ALPP, ALPPL2
22propylthiouracil45 3 1311.2ALPP, SLC17A5, GGT1
23tacrolimus45 51 1311.2ALB, SLC17A5, GGT1, GPT, ABCB4
24hyaluronic acid45 2610.2SLC17A5, GGT1, ALB, GPT, F2
25pge1459.1GUSB, ALPP, GPT, F2, SLC17A5
26silymarin459.1GUSB, SLC17A5, GGT1, GPT, UGT1A1, F2
27simvastatin45 51 61 30 26 1314.1F2, SLC17A5, ALPP, GPT, UGT1A1
28bezafibrate45 30 1311.1SLC17A5, GPT, ALPP, ABCB4, GGT1
29levamisole45 1310.0ALPPL2, ALPL, ALPP
30verapamil45 30 51 26 1313.0SLC17A5, GGT1, ALPP, GPT, ABCB4
31sevoflurane51 45 1311.0SLC17A5, GPT, ALB, ALPP, GGT1
32isoflurane51 45 1311.0SLC17A5, GPT, ALB, ALPP, GGT1
33phosphorus459.0ALB, SLC17A5, GGT1, ALPP, GPT
34polyethylene glycol459.0SLC17A5, ALPP, ALB, F2
35phenytoin45 51 30 1312.0SLC17A5, UGT1A1, ALB, GGT1, ALPP
36methotrexate51 45 1310.9ALB, SLC17A5, GGT1, F2, ABCB4, GPT
37ethanol45 51 26 1311.8GPT, ALPPL2, ALPL, GGT1, SLC17A5, GUSB
38phenobarbital45 30 51 1311.8GPT, GGT1, ALPP, UGT1A1, GUSB, SLC17A5
39vitamin b12458.7SLC17A5, GGT1, ALB, GUSB, GPT, ALPP
40ursodeoxycholic acid45 26 1310.7GPT, SLC17A5, F2, ABCB4, ALPP, GGT1
41thyroxine45 269.7UGT1A1, GPT, ALB, SLC17A5, GGT1, ALPP
42tamoxifen45 51 30 1311.7ALPP, UGT1A1, F2, SLC17A5, GGT1
43pyridoxal 5-phosphate458.7ALPP, GPT, ALB, GGT1, SLC17A5, ALPL
44heparin45 30 26 1311.5GGT1, ALB, ALPP, GUSB, F2, SLC17A5
45lactate458.4GUSB, GPT, ALB, ALPP, GGT1, SLC17A5
46creatinine458.3ALB, SLC17A5, ALPP, GGT1, F2, GUSB
47cholesterol45 30 26 1311.3GPT, ABCB4, ALB, ALPP, GGT1, SLC17A5
48magnesium45 26 1310.3ALB, SLC17A5, ALPP, ALPL, GPT, ALPPL2
49alanine458.0GPT, UGT1A1, F2, ALB, ABCB4, GGT1
50aspartate457.5GGT1, SLC17A5, F2, UGT1A1, ABCB4, GPT

GO Terms for genes affiliated with Choledocholithiasis

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Cellular components related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:00312258.7ALPPL2, ALPL, ALPP
2plasma membraneGO:00058867.7F2, ABCB4, ALPPL2, ALPL, ALPP, GGT1

Biological processes related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.8UGT1A1, F2
2small molecule metabolic processGO:00442817.5GGT1, ALB, ELOVL6, GUSB, GPT, UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00040359.0ALPP, ALPL, ALPPL2

Products for genes affiliated with Choledocholithiasis

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Sources for Choledocholithiasis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet