MCID: CHL039
MIFTS: 47

Choledocholithiasis malady

Gastrointestinal diseases category

Summaries for Choledocholithiasis

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66Wikipedia, 34MalaCards
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Wikipedia:66 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Choledocholithiasis is related to cholelithiasis and cholecystitis. An important gene associated with Choledocholithiasis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Selenium Pathway and Fatty acid, triacylglycerol, and ketone body metabolism. The compounds lactulose and glycocholate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are reproductive system and homeostasis/metabolism.

Aliases & Classifications for Choledocholithiasis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

choledocholithiasis 9 11 46 63


External Ids:

Disease Ontology9 DOID:11755
MeSH36 D042883

Related Diseases for Choledocholithiasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1cholelithiasis30.7ABCB4, GGT1, ALPP, ALPL, ALPPL2, GUSB
2cholecystitis30.7ELOVL6, GPT
3cholangitis30.6ALB, GPT, ABCB4, SLC17A5, GGT1, ALPP
4hepatitis30.5SLC17A5, GPT
5pancreatitis30.5SLC17A5, ALPP, ALPL, ALPPL2, ALB, ABCB4
6cholangiocarcinoma30.3ALPL, ALPP, ALPPL2, GGT1
7liver cirrhosis30.1GGT1, GUSB, F2, GPT, ALB, SLC17A5
8obstructive jaundice30.0GGT1, ALPP
9extrahepatic cholestasis30.0ALPP, GGT1
10primary sclerosing cholangitis30.0GPT, GGT1, ABCB4
11intrahepatic cholestasis29.9GGT1, SLC17A5, ABCB4, ALPP
12cholestasis29.9ABCB4, F2, GPT, ALB, ALPPL2, SLC17A5
13hypertension29.8ALB, F2, GGT1
14portal hypertension29.8GPT, ALB, SLC17A5, GGT1, F2
15hepatocellular carcinoma29.7F2, ABCB4, ALPL, SLC17A5, UGT1A1, GPT
16cholecystolithiasis10.4
17acute cholangitis10.3
18duodenitis10.2
19gallbladder disease10.1GGT1
20hepatitis e10.1GPT
21hydrops fetalis10.1GUSB
22opisthorchiasis10.1GGT1
23crigler-najjar syndrome10.1UGT1A1
24scrub typhus10.1GPT, SLC17A5
25pyridoxine deficiency10.1GPT, SLC17A5
26neonatal hemochromatosis10.1GGT1, SLC17A5
27hellp syndrome10.1SLC17A5, GPT
28neonatal jaundice10.1GUSB, UGT1A1
29ascariasis10.1
30sickle cell disease10.1
31bacteremia10.1
32cholestasis, progressive familial intrahepatic 110.1GGT1, ABCB4
33alcohol abuse10.1GGT1, GPT, SLC17A5
34hepatitis a10.1F2
35germ cell cancer10.1ALPP, ALPPL2
36endodermal sinus tumor10.1ALPPL2, ALPP
37biliary atresia10.1GGT1, GPT
38hypophosphatasia, infantile10.1ALPL, ALPP
39fascioliasis10.1GGT1, ALPP, SLC17A5
40familial hyperlipidemia10.1SLC17A5, GGT1, GPT
41splenomegaly10.1SLC17A5, GPT
42hypercholesterolemia10.1GGT1, SLC17A5, GPT
43periodontal disease10.1GUSB, SLC17A5, ALPP
44gonadoblastoma10.1ALPP, ALPPL2
45gingivitis10.1ALPP, GUSB
46dysfibrinogenemia10.1F2
47wilson disease10.1GPT, SLC17A5
48rickets10.1ALB, ALPP
49factor vii deficiency10.1F2
50kernicterus10.1ALB, UGT1A1

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to choledocholithiasis

Symptoms for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Choledocholithiasis

Drug clinical trials:

Search ClinicalTrials for Choledocholithiasis

Search NIH Clinical Center for Choledocholithiasis

Search CenterWatch for Choledocholithiasis

Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

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34MalaCards
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MalaCards organs/tissues related to Choledocholithiasis:

34
Liver, Testes, Heart

Animal Models for Choledocholithiasis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Choledocholithiasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2GGT1, ALPP, ALPL, GUSB, ABCB4, F2
2MP:00053767.1SLC17A5, F2, ABCB4, GUSB, ELOVL6, ALB

Publications for Choledocholithiasis

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Sources:
53PubMed
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Articles related to Choledocholithiasis:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Endoscopic papillary large balloon dilatation alone is safe and effective for the treatment of difficult choledocholithiasis in cases of Billroth II gastrectomy: a single center experience. (23392745)
2013
2
Non-invasive assessment of choledocholithiasis in patients with gallstones and abnormal liver function. (24124333)
2013
3
Consecutive versus separate sessions of endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for symptomatic choledocholithiasis. (23389062)
2013
4
Successful single-session endosonography-based endoscopic retrograde cholangiopancreatography without fluoroscopy in pregnant patients with suspected choledocholithiasis: a case series. (23798477)
2013
5
Endoscopic papillary balloon dilation for a 7-year-old girl with choledocholithiasis. (23679173)
2013
6
Risk factors of choledocholithiasis formation after liver transplantation. (23558078)
2013
7
Choledocholithiasis presenting with very high transaminase level. (23188856)
2012
8
Endoscopic treatment of difficult choledocholithiasis. (22709458)
2012
9
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
10
Endoscopic papillary balloon dilation for removal of choledocholithiasis: indications, advantages, complications, and long-term follow-up results. (21461066)
2011
11
Choledocholithiasis management in rural America: health disparity or health opportunity? (21571311)
2011
12
Laparoscopic exploration of the common bile duct with a rigid scope in patients with problematic choledocholithiasis. (20354699)
2010
13
Successful endoscopic extraction of a large impacted choledocholithiasis in the ampulla of vater: two interesting cases. (20590755)
2010
14
Extraction of surgical clip-induced "lollipop" choledocholithiasis. (20072999)
2010
15
A same day approach for choledocholithiasis using endoscopic stone removal followed by laparoscopic cholecystectomy: a retrospective study. (19260236)
2009
16
Single session versus separate session endoscopic ultrasonography plus endoscopic retrograde cholangiography in patients with low to moderate risk for choledocholithiasis. (19638088)
2009
17
Preoperative diagnosis of choledocholithiasis: the role of MRCP. (19516211)
2009
18
Liver test patterns in patients with acute calculous cholecystitis and/or choledocholithiasis. (19210291)
2009
19
Long-term complications of endoscopic biliary sphincterotomy for choledocholithiasis: a North-American perspective. (19888258)
2009
20
Patients with bulbar papilla and choledocholithiasis and their endoscopic management. (19453023)
2009
21
Management of choledocholithiasis in patients undergoing cholecystectomy. (19566539)
2009
22
Management of preoperatively suspected choledocholithiasis: a decision analysis. (18683008)
2008
23
Laparoendoscopic "rendezvous" versus laparoscopic antegrade sphincterotomy for choledocholithiasis. (18707043)
2008
24
Preoperative clinical and paraclinical predictors of choledocholithiasis. (18522887)
2008
25
Common bile duct thrombi secondary to hepatoma, with biliary invasion mimicking a choledocholithiasis (with video). (17258996)
2007
26
Suspected choledocholithiasis: endoscopic ultrasound or magnetic resonance cholangio-pancreatography? A systematic review. (18049172)
2007
27
Laparoscopic management of difficult recurrent choledocholithiasis. (17651582)
2007
28
Conversion rate for laparoscopic cholecystectomy after endoscopic retrograde cholangiography in the treatment of choledocholithiasis: does the time interval matter? (17031740)
2006
29
Outcomes of cholecystectomy after endoscopic sphincterotomy for choledocholithiasis. (16455464)
2006
30
EUS vs MRCP for detection of choledocholithiasis. (16860077)
2006
31
Role of endoscopic retrograde cholangiopancreatography in the management of suspected choledocholithiasis. (12618941)
2003
32
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
33
Recurrence of biliary symptoms after endoscopic sphincterectomy for choledocholithiasis in patients with gallbladder stones. (11911095)
2002
34
Diagnosis of choledocholithiasis and bile duct stenosis by magnetic resonance cholangiogram. (11966585)
2002
35
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
36
Choledocholithiasis in the Setting of Portal Hypertension. (11469971)
2001
37
Over-the-wire US catheter probe as an adjunct to ERCP in the detection of choledocholithiasis. (11726847)
2001
38
Management of choledocholithiasis found during laparoscopic cholecystectomy: a strategy based on the use of postoperative endoscopic retrograde cholangiography and sphincterotomy. (11332046)
2001
39
The rendezvous technique for the treatment of choledocholithiasis. (11577321)
2001
40
Choledocholithiasis: endoscopic versus laparoscopic management. (9926747)
1999
41
Eight years' experience with the use of a transcystic common bile duct duodenal double-lumen catheter for the treatment of choledocholithiasis. (9780991)
1998
42
Ofuji's papuloerythroderma following choledocholithiasis with secondary sepsis: complete resolution with surgery. (9692313)
1998
43
Endoscopic ultrasonography for diagnosing choledocholithiasis: a prospective comparative study with ultrasonography and computed tomography. (9040999)
1997
44
Choledocholithiasis and gallstone pancreatitis. (9512804)
1997
45
Biliary stents as temporary treatment for choledocholithiasis in pregnant patients. (9260726)
1997
46
Transduodenal sphincteroplasty in the treatment of choledocholithiasis in pregnancy. (8976069)
1996
47
Endoscopic biliary sphincterotomy and stone extraction in a child with choledocholithiasis complicating Byler's disease. (8985855)
1996
48
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
49
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
50
Laparoscopic cholecystectomy: laboratory predictors of choledocholithiasis. (7944040)
1994

Variations for Choledocholithiasis

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Expression for genes affiliated with Choledocholithiasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for genes affiliated with Choledocholithiasis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters
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Compounds for genes affiliated with Choledocholithiasis

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Sources:
46Novoseek, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 3BitterDB
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Compounds related to Choledocholithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1lactulose4610.0SLC17A5, GUSB, GPT
2glycocholate469.8GUSB, GPT, ABCB4, SLC17A5
3ethyl glucuronide46 2510.8GGT1, UGT1A1, GUSB
4gamma globulin469.7ALB, GGT1, SLC17A5
5hepaplastin469.7F2, GPT, SLC17A5, ALB
6aminopyrine469.6GPT, F2, SLC17A5, GGT1
7glycyrrhizin46 3010.6GPT, GUSB, SLC17A5
8rifampicin46 30 6211.6SLC17A5, GGT1, GPT, UGT1A1
9zidovudine46 52 1211.5SLC17A5, GPT, GUSB, ALB
10mycophenolate mofetil46 52 1211.5GPT, UGT1A1, ALB, GGT1
11uric acid46 2510.4SLC17A5, GGT1, GPT, ALB
127,8-dihydroneopterin46 2510.4ALPPL2, ALPL, ALPP
13dihydroneopterin triphosphate46 2510.3ALPP, ALPPL2, ALPL
14dihydroxyacetone46 2510.3ALPP, ALPL, ALPPL2
15acetaminophen46 3 52 25 1213.3SLC17A5, GPT, UGT1A1, F2, GGT1
16antipyrine46 1210.3GUSB, ALB, GGT1, SLC17A5, F2
17valproic acid46 52 25 1212.3SLC17A5, GGT1, ALB, GPT, UGT1A1
18vitamin b6469.3ALB, ALPP, SLC17A5, ALPL
194-Nitrophenol259.3ALPP, ALPPL2, ALPL
20nash469.3GPT, SLC17A5, GGT1
21Dihydroxyacetone phosphate259.3ALPL, ALPP, ALPPL2
22propylthiouracil46 3 1211.2ALPP, SLC17A5, GGT1
23tacrolimus46 52 1211.2ALB, SLC17A5, GGT1, GPT, ABCB4
24hyaluronic acid46 2510.2SLC17A5, GGT1, ALB, GPT, F2
25pge1469.1GUSB, ALPP, GPT, F2, SLC17A5
26silymarin469.1GUSB, SLC17A5, GGT1, GPT, UGT1A1, F2
27simvastatin46 52 62 30 25 1214.1F2, SLC17A5, ALPP, GPT, UGT1A1
28bezafibrate46 30 1211.1SLC17A5, GPT, ALPP, ABCB4, GGT1
29levamisole46 1210.0ALPPL2, ALPL, ALPP
30verapamil46 30 52 25 1213.0SLC17A5, GGT1, ALPP, GPT, ABCB4
31sevoflurane52 46 1211.0SLC17A5, GPT, ALB, ALPP, GGT1
32isoflurane52 46 1211.0SLC17A5, GPT, ALB, ALPP, GGT1
33phosphorus469.0ALB, SLC17A5, GGT1, ALPP, GPT
34polyethylene glycol469.0SLC17A5, ALPP, ALB, F2
35phenytoin46 52 30 1212.0SLC17A5, UGT1A1, ALB, GGT1, ALPP
36methotrexate52 46 1210.9ALB, SLC17A5, GGT1, F2, ABCB4, GPT
37ethanol46 52 25 1211.8GPT, ALPPL2, ALPL, GGT1, SLC17A5, GUSB
38phenobarbital46 30 52 1211.8GPT, GGT1, ALPP, UGT1A1, GUSB, SLC17A5
39vitamin b12468.7SLC17A5, GGT1, ALB, GUSB, GPT, ALPP
40ursodeoxycholic acid46 25 1210.7GPT, SLC17A5, F2, ABCB4, ALPP, GGT1
41thyroxine46 259.7UGT1A1, GPT, ALB, SLC17A5, GGT1, ALPP
42tamoxifen46 52 30 1211.7ALPP, UGT1A1, F2, SLC17A5, GGT1
43pyridoxal 5-phosphate468.7ALPP, GPT, ALB, GGT1, SLC17A5, ALPL
44heparin46 30 25 1211.5GGT1, ALB, ALPP, GUSB, F2, SLC17A5
45lactate468.4GUSB, GPT, ALB, ALPP, GGT1, SLC17A5
46creatinine468.3ALB, SLC17A5, ALPP, GGT1, F2, GUSB
47cholesterol46 30 25 1211.3GPT, ABCB4, ALB, ALPP, GGT1, SLC17A5
48magnesium46 25 1210.3ALB, SLC17A5, ALPP, ALPL, GPT, ALPPL2
49alanine468.0GPT, UGT1A1, F2, ALB, ABCB4, GGT1
50aspartate467.5GGT1, SLC17A5, F2, UGT1A1, ABCB4, GPT

GO Terms for genes affiliated with Choledocholithiasis

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17Gene Ontology
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Cellular components related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312258.7ALPP, ALPL, ALPPL2
2plasma membraneGO:0058867.7ABCB4, ALPPL2, ALPL, ALPP, GGT1, SLC17A5

Biological processes related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.8UGT1A1, F2
2small molecule metabolic processGO:0442817.5GGT1, ALB, ELOVL6, GUSB, GPT, UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040359.0ALPP, ALPL, ALPPL2

Products for genes affiliated with Choledocholithiasis

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  • Antibodies
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Sources for Choledocholithiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet