MCID: CHL039
MIFTS: 34

Choledocholithiasis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Choledocholithiasis

Aliases & Descriptions for Choledocholithiasis:

Name: Choledocholithiasis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11755
MeSH 42 D042883
UMLS 69 C0701818

Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to cholelithiasis and gastric neuroendocrine tumor type 1. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Lysosome and FOXA2 and FOXA3 transcription factor networks. The drugs Etomidate and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 cholelithiasis 10.3
2 gastric neuroendocrine tumor type 1 10.3 GPT SLC17A5
3 radiation induced cancer 10.2 GPT SLC17A5
4 familial progressive hyperpigmentation 10.2 F2 GPT
5 cholangitis 10.2
6 megaloblastic anemia 10.2 GPT SLC17A5
7 maxillary sinusitis 10.2 F2 GPT
8 anhidrosis 10.2 ABCB4 CTSC
9 jejunal neuroendocrine tumor 10.1 ALPP GPT
10 nondystrophic myotonia 10.1 ALB F2
11 periodontitis 1, juvenile 10.1 CTSC SLC17A5
12 renal artery disease 10.1 ALB UGT1A1
13 freiberg's disease 10.1 ALB F2
14 pulpitis 10.1 F2 SLC17A5
15 pharynx carcinoma in situ 10.1 ALB F2
16 duane retraction syndrome 10.1 ALB F2
17 chronic inflammatory demyelinating polyneuritis 10.1 ALB F2
18 isolated growth hormone deficiency 10.1 ALB GPT
19 not otherwise specified 3-mga-uria type 10.1 GPT SLC17A5
20 angelucci's syndrome 10.1 ALB F2
21 pancreatitis 10.1
22 autonomic peripheral neuropathy 10.1 ABCB4 ALB
23 ovarian papillary cystadenoma 10.1 ALB F2
24 myopia 10.1 ALB F2
25 bladder sarcoma 10.1 ALB GPT
26 eagle syndrome 10.1 ALB F2
27 acute proliferative glomerulonephritis 10.1 F2 GPT SLC17A5
28 atrophic vulva 10.1 ALB F2
29 cholecystolithiasis 10.1
30 hereditary hemorrhagic telangiectasia 10.0 F2 GPT SLC17A5
31 cholecystitis 10.0
32 klinefelter's syndrome 10.0 ALB ALPP
33 chronic rheumatic pericarditis 10.0 ABCB4 ALB SLC17A5
34 primary pigmented nodular adrenocortical disease 10.0 ABCB4 UGT1A1
35 benign deep fibrous histiocytoma 10.0 ALB F2 GPT
36 hemolytic-uremic syndrome 10.0 ALB F2 GPT
37 fiedler's myocarditis 10.0 ALB F2 GPT
38 heart aneurysm 10.0 ABCB4 ALB F2
39 acute cholangitis 10.0
40 capillary hemangioma 10.0 ALB F2
41 infiltrating ureter transitional cell carcinoma 10.0 ALB F2 SLC17A5
42 anal fistula 10.0 ALB F2 SLC17A5
43 ischemic optic neuropathy 10.0 ALB F2
44 orbital cancer 10.0 CTSC SOBP
45 fallopian tube leiomyosarcoma 9.9 ALB F2 GPT GUSB
46 gastrointestinal adenoma 9.9 ABCB4 ALB F2 GPT
47 bacterial meningitis 9.9 ABCB4 ALB F2 GPT
48 female infertility of uterine origin 9.9 ALB F2 GPT SLC17A5
49 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 9.9 ALB F2 GPT SLC17A5
50 acute monocytic leukemia 9.9 ALB F2 GPT SLC17A5

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis

Symptoms & Phenotypes for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Meperidine Approved Phase 4 57-42-1 4058
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 Adjuvants, Anesthesia Phase 4
6 Analgesics Phase 4
7 Analgesics, Opioid Phase 4
8 Anesthetics Phase 4
9 Anesthetics, General Phase 4
10 Anesthetics, Intravenous Phase 4
11 Anti-Anxiety Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 GABA Agents Phase 4
14 GABA Modulators Phase 4
15 Hypnotics and Sedatives Phase 4
16 Narcotics Phase 4
17 Neurotransmitter Agents Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Psychotropic Drugs Phase 4
20 Tranquilizing Agents Phase 4
21 Cholagogues and Choleretics Phase 4
22 Gastrointestinal Agents Phase 4
23
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
24
Cefotaxime Approved 63527-52-6 456256 5742673
25
Cefoxitin Approved 35607-66-0 441199
26 Plasminogen Early Phase 1
27 Plasminogen Activator Inhibitor 1 Early Phase 1
28 Plasminogen Inactivators Early Phase 1
29 Tissue Plasminogen Activator Early Phase 1
30 glucagon
31 Glucagon-Like Peptide 1
32 Anti-Infective Agents
33 Anti-Infective Agents, Local
34 Chlorhexidine gluconate
35 Disinfectants
36 Anti-Bacterial Agents
37 Antibiotics, Antitubercular
38 Butylscopolammonium Bromide
39 Scopolamine hydrobromide 114-49-8
40 Antitubercular Agents
41 Cephalosporins

Interventional clinical trials:

(show all 40)
id Name Status NCT ID Phase
1 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4
2 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4
3 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
4 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
5 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
6 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234
7 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581
8 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
9 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400
10 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
11 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
12 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979
13 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729
14 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686
15 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475
16 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891
17 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
18 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958
19 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552
20 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269
21 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240
22 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845
23 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
24 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
25 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186
26 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
27 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285
28 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474
29 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Recruiting NCT03074201
30 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453
31 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
32 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Recruiting NCT02554097
33 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
34 Los Angeles Prospective GI Biliary and EUS Series Recruiting NCT02196935
35 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Enrolling by invitation NCT02647593
36 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Enrolling by invitation NCT02276157
37 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Not yet recruiting NCT02958059
38 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846
39 Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy Terminated NCT00124033
40 Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance Withdrawn NCT01475864

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

39
Liver, Testes, Heart

Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 606)
id Title Authors Year
1
Accuracy of ASGE criteria for the prediction of choledocholithiasis. ( 28071059 )
2017
2
Laparoscopic Common Bile Duct Exploration Versus Open Approach in Cirrhotic Patients with Choledocholithiasis: A Retrospective Study. ( 27509535 )
2016
3
Endoscopic management of choledocholithiasis and cholelithiasis in patients with cirrhosis. ( 26799755 )
2016
4
Re: Endoscopic large balloon sphincteroplasty is a useful, safe adjunct for difficult to treat choledocholithiasis. ( 27910279 )
2016
5
Utility of MRCP in clinical decision making of suspected choledocholithiasis: An institutional analysis and literature review. ( 27986260 )
2016
6
Randomized clinical trial of intraoperative endoscopic retrograde cholangiopancreatography versus laparoscopic bile duct exploration in patients with choledocholithiasis. ( 27302483 )
2016
7
Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis: Prospective comparative study. ( 27759652 )
2016
8
Safe laparoscopic clearance of the common bile duct in emergently admitted patients with choledocholithiasis and cholangitis. ( 27212991 )
2016
9
Choledocholithiasis: Evaluation, Treatment, and Outcomes. ( 27904245 )
2016
10
Choledocholithiasis Without Cholelithiasis: Should the Gallbladder Stay or Should It Go? ( 26738738 )
2016
11
A scoring system for the prediction of choledocholithiasis: a prospective cohort study. ( 26922689 )
2016
12
Ultrathin choledochoscope improves outcomes in the treatment of gallstones and suspected choledocholithiasis. ( 27796141 )
2016
13
Routine endoscopic ultrasound in moderate and indeterminate risk patients of suspected choledocholithiasis to avoid unwarranted ERCP: A prospective randomized blinded study. ( 27455855 )
2016
14
Automated development of artificial neural networks for clinical purposes: Application for predicting the outcome of choledocholithiasis surgery. ( 27261565 )
2016
15
Markedly Elevated Liver Enzymes in Choledocholithiasis in the absence of Hepatocellular Disease: Case Series and Literature Review. ( 27408902 )
2016
16
Single-stage management with combined tri-endoscopic approach for concomitant cholecystolithiasis and choledocholithiasis. ( 27126621 )
2016
17
Nationwide Assessment of Trends in Choledocholithiasis Management in the United States From 1998 to 2013. ( 27556900 )
2016
18
Commentary on "Prospective Evaluation of the Clinical Features of Choledocholithiasis: Focus on Abdominal Pain". ( 27135725 )
2016
19
Feasibility of nonradiation EUS-based ERCP in patients with uncomplicated choledocholithiasis (with video). ( 27040099 )
2016
20
Intraoperative endoscopic nasobiliary drainage over primary closure of the common bile duct for choledocholithiasis combined with cholecystolithiasis: a cohort study of 211 cases. ( 27864721 )
2016
21
Safety of immediate endoscopic sphincterotomy in acute suppurative cholangitis caused by choledocholithiasis. ( 26862368 )
2016
22
Endoscopic versus laparoscopic treatment for choledocholithiasis: a prospective randomized controlled trial. ( 27857966 )
2016
23
Advances of recurrent risk factors and management of choledocholithiasis. ( 27610642 )
2016
24
No Stone Left Unturned: Using Choledocholithiasis to Open a Papillary Stenosis via a Choledochodudenal Fistula. ( 26958565 )
2016
25
Factors and Outcomes Associated with MRCP Use prior to ERCP in Patients at High Risk for Choledocholithiasis. ( 27446845 )
2016
26
Role of laparoscopic common bile duct exploration in the management of choledocholithiasis. ( 27231516 )
2016
27
The utility and yield of endoscopic ultrasonography for suspected choledocholithiasis in common gastroenterology practice. ( 27556688 )
2016
28
Laparo-endoscopic rendez-vous versus sequential "delayed" approach in patients with choledocholithiasis. ( 27981825 )
2016
29
Prospective Evaluation of the Clinical Features of Choledocholithiasis: Focus on Abdominal Pain. ( 27135724 )
2016
30
Endoscopic ultrasonography versus magnetic resonance cholangiopancreatography for suspected choledocholithiasis: Comments from the radiologists'. ( 27080612 )
2016
31
Prevalence of Cholelithiasis and Choledocholithiasis in Morbidly Obese South Indian Patients and the Further Development of Biliary Calculus Disease After Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass. ( 26910024 )
2016
32
Endoscopic ultrasound versus magnetic resonance cholangiopancreatography in suspected choledocholithiasis: A systematic review. ( 27080611 )
2016
33
Surgical Management of Choledocholithiasis: A Disappearing Skill. ( 27556413 )
2016
34
Single-session laparoscopic cholecystectomy and ERCP: a valid option for the management of choledocholithiasis. ( 26975235 )
2016
35
Accuracy of ASGE criteria for the prediction of choledocholithiasis. ( 27063334 )
2016
36
Scoring system to preoperatively predict choledocholithiasis. ( 27146040 )
2016
37
LABEL procedure: Laser-Assisted Bile duct Exploration by Laparoendoscopy for choledocholithiasis: improving surgical outcomes and reducing technical failure. ( 27572062 )
2016
38
Magnetic Resonance Cholangiopancreatography Still Plays a Role in the Preoperative Evaluation of Choledocholithiasis andA Biliary Pathology. ( 26922606 )
2016
39
Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention. ( 27298714 )
2016
40
Same-day laparoscopic cholecystectomy and ERCP for choledocholithiasis. ( 27633358 )
2016
41
The Usefulness of Early Endoscopic Ultrasonography in Acute Biliary Pancreatitis with Undetectable Choledocholithiasis on Multidetector Computed Tomography. ( 27780944 )
2016
42
Severe Elevation of Liver Tests in Choledocholithiasis: An Uncommon Occurrence With Important Clinical Implications. ( 27466169 )
2016
43
Use of an esophageal stent for successful treatment of significant choledocholithiasis to facilitate direct cholangioscopy. ( 27102830 )
2016
44
A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis. ( 27031649 )
2016
45
The value of magnetic resonance cholangiopancreatography for the exclusion of choledocholithiasis. ( 27181286 )
2016
46
Accuracy of scoring systems for suspected choledocholithiasis: A 5-variable score system versus ASGE clinical guidelines. ( 27089986 )
2016
47
The Efficacy of Clinical Predictors for Patients with Intermediate Risk of Choledocholithiasis. ( 27640085 )
2016
48
An analysis of omitting biliary tract imaging in 668 subjects admitted to an acute care surgery service with biochemical evidence of choledocholithiasis. ( 26506555 )
2015
49
Laparoscopic treatment of choledocholithiasis. ( 25882100 )
2015
50
Detectability of Choledocholithiasis on CT: The Effect of Positive Intraduodenal Enteric Contrast on Portovenous Contrast-enhanced Studies. ( 26346009 )
2015

Variations for Choledocholithiasis

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for Choledocholithiasis

Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.89 CTSC GUSB SLC17A5
2 10.6 ALB F2

GO Terms for Choledocholithiasis

Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.13 ALB CTSC F2
2 extracellular space GO:0005615 9.02 ALB CTSC F2 GPT GUSB

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to estradiol stimulus GO:0071392 9.16 ABCB4 UGT1A1
2 acute-phase response GO:0006953 8.96 F2 UGT1A1
3 response to organic substance GO:0010033 8.8 ABCB4 CTSC UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Choledocholithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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