MCID: CHL039
MIFTS: 43

Choledocholithiasis malady

Summaries for Choledocholithiasis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Choledocholithiasis is related to cholelithiasis and cholangitis. An important gene associated with Choledocholithiasis is GUSB (glucuronidase, beta), and among its related pathways are Selenium Pathway and NAD metabolism. The compounds heparin and lactulose have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

Aliases & Classifications for Choledocholithiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

choledocholithiasis 8 10 44 60


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Disease Ontology8 DOID:11755
MeSH34 D042883

Related Diseases for Choledocholithiasis

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17GeneCards, 18GeneDecks
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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1cholelithiasis30.7ALPPL2, ALPP, GUSB, UGT1A1, GPT, ABCB4
2cholangitis30.6GPT, ABCB4, SLC17A5, GGT1, ALPL, ALPP
3pancreatitis30.5ABCB4, SLC17A5, GGT1, ALPL, ALPP, ALB
4cholecystitis30.5ELOVL6, GPT
5hepatitis30.3SLC17A5, GPT
6acute pancreatitis30.2GPT, SLC17A5
7cholangiocarcinoma30.1GGT1, ALPL, ALPP, ALPPL2
8liver cirrhosis30.1GUSB, GPT, F2, SLC17A5, GGT1, ALB
9cholestasis30.1GPT, ABCB4, F2, SLC17A5, GGT1, ALPL
10hepatitis a30.0F2
11sickle cell disease30.0GUSB, UGT1A1
12hepatocellular carcinoma30.0UGT1A1, GPT, ABCB4, F2, SLC17A5, GGT1
13obstructive jaundice29.8GGT1, ALPP
14extrahepatic cholestasis29.8ALPP, GGT1
15crohn's disease29.8ALB
16intrahepatic cholestasis29.8ABCB4, SLC17A5, GGT1, ALPP
17peritonitis29.8ALB, F2
18hypertension29.8ALB, GGT1, F2
19portal hypertension29.8GPT, F2, SLC17A5, GGT1, ALB
20cholecystolithiasis10.3
21acute cholangitis10.3
22duodenitis10.2
23ascariasis10.0
24schistosomiasis10.0GUSB
25hepatitis e10.0GPT
26gallbladder disease10.0GGT1
27coronary heart disease10.0GGT1
28ovarian cancer10.0GUSB
29hydrops fetalis10.0GUSB
30glucose intolerance10.0GPT
31rheumatoid arthritis10.0GUSB
32alcohol dependence10.0GGT1
33cryoglobulinemia10.0SLC17A5
34substance abuse10.0GGT1
35sarcoma10.0GUSB
36alpha thalassemia10.0UGT1A1
37biliary atresia10.0GGT1, GPT
38stomach cancer10.0GUSB
39wilson disease10.0SLC17A5, GPT
40scrub typhus10.0SLC17A5, GPT
41pyridoxine deficiency10.0GPT, SLC17A5
42pancreatic cancer10.0GUSB, GGT1
43neonatal hemochromatosis10.0SLC17A5, GGT1
44dysgerminoma10.0ALPP
45opisthorchiasis10.0GGT1
46hellp syndrome10.0SLC17A5, GPT
47arthropathy10.0ALPL
48adenoma10.0GGT1
49respiratory failure10.0ALPL
50hyperuricemia10.0GGT1, GPT

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to choledocholithiasis

Clinical Features for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Choledocholithiasis

Drug clinical trials:

Search ClinicalTrials for Choledocholithiasis

Search NIH Clinical Center for Choledocholithiasis

Search CenterWatch for Choledocholithiasis

Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

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32MalaCards
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MalaCards organs/tissues related to Choledocholithiasis:

32
Liver, Testes, Heart

Animal Models for Choledocholithiasis or affiliated genes

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Publications for Choledocholithiasis

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Sources:
50PubMed
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Articles related to Choledocholithiasis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Selective utilization of pre-operative endoscopic ultrasound to exclude choledocholithiasis prior to laparoscopic cholecystectomy: a retrospective study. (23635442)
2013
2
Choledocholithiasis presenting with very high transaminase level. (23188856)
2012
3
Laparoendoscopic rendezvous versus preoperative ERCP and laparoscopic cholecystectomy for the management of cholecysto-choledocholithiasis: interim analysis of a controlled randomized trial. (22261836)
2012
4
The relationship between gallbladder status and recurrent biliary complications in patients with choledocholithiasis following endoscopic treatment. (23158033)
2012
5
Association of a glucose-6-phosphate deficiency and a Gilbert syndrome as risk factors for a severe choledocholithiasis in a 2-month-old male infant. (21793186)
2012
6
Preoperative MRCP to detect choledocholithiasis in acute calculous cholecystitis. (21983892)
2012
7
Endoscopic treatment of the choledocholithiasis--effectiveness, safety and limitations of the method. (22935454)
2012
8
Does the bile duct angulation affect recurrence of choledocholithiasis? (22039327)
2011
9
Bile bacterial flora and its in vitro resistance pattern in patients with acute cholangitis resulting from choledocholithiasis. (21504380)
2011
10
Laparoscopic exploration of the common bile duct to relieve choledocholithiasis in children. (21290137)
2011
11
Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. (21374660)
2011
12
Successful endoscopic extraction of a large impacted choledocholithiasis in the ampulla of vater: two interesting cases. (20590755)
2010
13
Gallstone Ileus, Bouveret's Syndrome and Choledocholithiasis in a Patient with Billroth II Gastrectomy - A Case Report of Combined Endoscopic and Surgical Therapy. (21103231)
2010
14
Patients with bulbar papilla and choledocholithiasis and their endoscopic management. (19453023)
2009
15
A randomized, clinical trial to compare endoscopic sphincterotomy and subsequent laparoscopic cholecystectomy with primary laparoscopic bile duct exploration during cholecystectomy in higher risk patients with choledocholithiasis. (19792866)
2009
16
Laparoscopic treatment of choledocholithiasis with novel self-releasing biliary stent. (19215211)
2009
17
Rare cause of biliary obstruction by ascariasis associated with choledocholithiasis. (19062498)
2008
18
Common bile duct exploration for choledocholithiasis. (18992597)
2008
19
Choledocholithiasis, endoscopic retrograde cholangiopancreatography, and laparoscopic common bile duct exploration. (18790152)
2008
20
Duplex gall bladder associated with choledocholithiasis, cholecystitis, gall bladder rupture and septic peritonitis in a cat. (17610469)
2007
21
Conversion rate for laparoscopic cholecystectomy after endoscopic retrograde cholangiography in the treatment of choledocholithiasis: does the time interval matter? (17031740)
2006
22
Two-stage treatment with preoperative endoscopic retrograde cholangiopancreatography (ERCP) compared with single-stage treatment with intraoperative ERCP for patients with symptomatic cholelithiasis with possible choledocholithiasis. (17001567)
2006
23
Endoscopic Ultrasonograpy for Choledocholithiasis and Biliary Malignancy. (15769435)
2005
24
Echo-endoscopy versus endoscopic retrograde cholangiography for the diagnosis of choledocholithiasis: the influence of the size of the stone and diameter of the common bile duct. (16444379)
2005
25
Limitations of fluoroscopic intraoperative cholangiography in cases suggestive of choledocholithiasis. (15954836)
2005
26
Endoscopic sphincterotomy vs. endoscopic papillary balloon dilation for choledocholithiasis in patients with liver cirrhosis and coagulopathy. (15278041)
2004
27
Cholecystectomy after treatment of choledocholithiasis: on firmer ground. (12891568)
2003
28
Management of choledocholithiasis: comparison between laparoscopic common bile duct exploration and intraoperative endoscopic sphincterotomy. (14669352)
2003
29
Helical CT cholangiography in the evaluation of the biliary tract: application to the diagnosis of choledocholithiasis. (11740611)
2002
30
Management of choledocholithiasis found during laparoscopic cholecystectomy: a strategy based on the use of postoperative endoscopic retrograde cholangiography and sphincterotomy. (11332046)
2001
31
Choledochocolonic fistula secondary to primary choledocholithiasis. (11474397)
2001
32
The continuing search for a good working relationship between endoscopic and surgical teams in the treatment of cholecysto-choledocholithiasis. (11677500)
2001
33
Rapid diagnosis of choledocholithiasis using biochemical tests in patients undergoing laparoscopic cholecystectomy. (11462888)
2001
34
Long-term stenting for choledocholithiasis. (10946479)
2000
35
A history of the dissolution of retained choledocholithiasis. (11044519)
2000
36
Use of magnetic resonance cholangiography in the diagnosis of choledocholithiasis: prospective comparison with a reference imaging method. (9862837)
1999
37
Role of endoscopic retrograde cholangiopancreatography for suspected choledocholithiasis in patients undergoing laparoscopic cholecystectomy. (9468423)
1998
38
Bilobed gallbladder with gallstones and choledocholithiasis. (9752754)
1998
39
Endoscopic biliary manometry in cholecystectomized patients with and without choledocholithiasis. (9684111)
1998
40
Laparoscopic biliary guide wire: a simplified approach to choledocholithiasis. (9087837)
1997
41
Treatment of acute cholangitis due to choledocholithiasis in elderly and younger patients. (9336514)
1997
42
Endoscopic biliary sphincterotomy and stone extraction in a child with choledocholithiasis complicating Byler's disease. (8985855)
1996
43
A prospective study of the safety of endoscopic therapy for choledocholithiasis in an outpatient population. (8759649)
1996
44
Biliary symptoms and complications more than 8 years after endoscopic sphincterotomy for choledocholithiasis. (8608900)
1996
45
Stenting for choledocholithiasis: temporizing or therapeutic? (8633529)
1996
46
Peroperative endoscopic sphincterotomy during laparoscopic cholecystectomy for choledocholithiasis. (7489189)
1995
47
Prospective evaluation in 121 consecutive unselected patients undergoing laparoscopic treatment of choledocholithiasis. (7552015)
1995
48
Appraisal of surgical and endoscopic management of choledocholithiasis. (8085972)
1994
49
Diagnosis of choledocholithiasis: value of MR cholangiography. (8092021)
1994
50
The endoscopic diagnosis of the invaginating ampulla of Vater mimicking choledocholithiasis. (8273781)
1994

Genetic Variations for Choledocholithiasis

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Expression for genes affiliated with Choledocholithiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for genes affiliated with Choledocholithiasis

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Choledocholithiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6F2, GGT1, ALB
2
NAD metabolism
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8.9ALPPL2, ALPP, ALPL
38.9ALPP, ALPPL2, ALPL
4
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6.7ELOVL6, GPT, ABCB4, PNLIPRP1, GGT1, ALPL

Compounds for genes affiliated with Choledocholithiasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Choledocholithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.4GUSB
2lactulose4410.2GUSB, GPT, SLC17A5
3glycyrrhizin44 2811.1GUSB, GPT, SLC17A5
4glycocholate4410.1SLC17A5, ABCB4, GPT, GUSB
5gamma globulin4410.0SLC17A5, GGT1, ALB
6ethyl glucuronide44 2411.0GGT1, UGT1A1, GUSB
7nash4410.0GGT1, GPT, SLC17A5
8d-glucaric acid4410.0GGT1, GUSB
9hepaplastin449.9ALB, SLC17A5, GPT, F2
10nevirapine44 49 1111.9SLC17A5, GGT1, GPT
11aminopyrine449.9SLC17A5, F2, GPT, GGT1
12zidovudine44 1110.8GPT, ALB, SLC17A5, GUSB
13buprenorphine44 28 1111.8GUSB, UGT1A1, SLC17A5
14rifampicin44 28 5911.8GGT1, SLC17A5, GPT, UGT1A1
15mycophenolate mofetil44 49 1111.8UGT1A1, GGT1, GPT, ALB
16naltrexone44 49 28 1112.8SLC17A5, GGT1, UGT1A1
17opium449.8GUSB, SLC17A5
18antipyrine44 1110.7ALB, GGT1, SLC17A5, F2, GUSB
19acetaminophen44 2 49 11 2413.6F2, GGT1, SLC17A5, UGT1A1, GPT
20valproic acid44 49 11 2412.6ALB, GGT1, SLC17A5, GPT, UGT1A1
21tacrolimus44 49 1111.5GGT1, SLC17A5, GPT, ABCB4, ALB
22hyaluronic acid44 2410.5GGT1, GPT, F2, SLC17A5, ALB
23silymarin449.5GPT, F2, GUSB, UGT1A1, GGT1, SLC17A5
24methotrexate44 49 1111.4ABCB4, SLC17A5, F2, GGT1, ALB, GPT
25vitamin b6449.3SLC17A5, ALB, ALPP, ALPL
267,8-dihydroneopterin44 2410.3ALPP, ALPPL2, ALPL
27dihydroneopterin triphosphate44 2410.2ALPP, ALPL, ALPPL2
28dihydroxyacetone44 2410.2ALPP, ALPL, ALPPL2
29pge1449.2GPT, ALPP, SLC17A5, F2, GUSB
30ethanol44 49 11 2412.1ALPL, GGT1, SLC17A5, GPT, GUSB, ALPPL2
31bezafibrate44 28 1111.1ALPP, GPT, GGT1, ABCB4, SLC17A5
32sevoflurane44 1110.1GGT1, ALPP, GPT, SLC17A5, ALB
33isoflurane44 1110.1ALB, ALPP, GGT1, SLC17A5, GPT
34phosphorus449.1SLC17A5, GPT, GGT1, ALPP, ALB
35verapamil44 49 28 11 2413.1ABCB4, ALPP, GGT1, SLC17A5, GPT
36levamisole44 1110.1ALPP, ALPL, ALPPL2
37polyethylene glycol449.1F2, SLC17A5, ALPP, ALB
38simvastatin44 49 59 28 11 2414.1ALPP, SLC17A5, F2, UGT1A1, GPT
39phenytoin44 49 28 1112.0ALB, ALPP, UGT1A1, GGT1, SLC17A5
40phenobarbital44 28 1110.9UGT1A1, SLC17A5, GUSB, ALPP, GGT1, GPT
41vitamin b12448.9GUSB, GGT1, ALPP, SLC17A5, GPT, ALB
42ursodeoxycholic acid44 11 2410.9ABCB4, GPT, F2, SLC17A5, GGT1, ALPP
43pyridoxal 5-phosphate448.9GPT, SLC17A5, GGT1, ALPL, ALPP, ALB
44thyroxine44 249.8UGT1A1, GPT, SLC17A5, GGT1, ALB, ALPP
45lactate448.6SLC17A5, ALB, ALPP, GGT1, F2, GPT
46creatinine448.6ALB, GGT1, SLC17A5, F2, ALPP, GPT
47tamoxifen44 49 28 1111.5F2, ALPP, SLC17A5, GGT1, UGT1A1
48cholesterol44 28 11 2411.5SLC17A5, ALB, UGT1A1, GPT, ABCB4, ALPP
49alanine448.3UGT1A1, GPT, ALB, F2, SLC17A5, ABCB4
50aspartate447.9SLC17A5, GUSB, ALB, ALPP, ALPL, GGT1

GO Terms for genes affiliated with Choledocholithiasis

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16Gene Ontology
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Cellular components related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:0312258.9ALPPL2, ALPP, ALPL
2extracellular spaceGO:0056158.1ALB, ALPL, LGI1, PNLIPRP1, F2, CTRB1

Biological processes related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1ELOVL6, ALB, GGT1, ABCB4, GPT, UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040358.9ALPPL2, ALPP, ALPL

Products for genes affiliated with Choledocholithiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Choledocholithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet