MCID: CHL039
MIFTS: 43

Choledocholithiasis malady

Summaries for Choledocholithiasis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Choledocholithiasis is related to cholelithiasis and cholangitis. An important gene associated with Choledocholithiasis is GUSB (glucuronidase, beta), and among its related pathways are Selenium Pathway and NAD metabolism. The compounds heparin and lactulose have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

Aliases & Classifications for Choledocholithiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

choledocholithiasis 8 10 44 60


External Ids:

Disease Ontology8 DOID:11755
MeSH34 D042883

Related Diseases for Choledocholithiasis

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17GeneCards, 18GeneDecks
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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1cholelithiasis30.7ALPPL2, ALPP, GUSB, UGT1A1, GPT, ABCB4
2cholangitis30.6GPT, ABCB4, SLC17A5, GGT1, ALPL, ALPP
3pancreatitis30.5ABCB4, SLC17A5, GGT1, ALPL, ALPP, ALB
4cholecystitis30.5ELOVL6, GPT
5hepatitis30.3SLC17A5, GPT
6acute pancreatitis30.2GPT, SLC17A5
7cholangiocarcinoma30.1GGT1, ALPL, ALPP, ALPPL2
8liver cirrhosis30.1GUSB, GPT, F2, SLC17A5, GGT1, ALB
9cholestasis30.1GPT, ABCB4, F2, SLC17A5, GGT1, ALPL
10hepatitis a30.0F2
11sickle cell disease30.0GUSB, UGT1A1
12hepatocellular carcinoma30.0UGT1A1, GPT, ABCB4, F2, SLC17A5, GGT1
13obstructive jaundice29.8GGT1, ALPP
14extrahepatic cholestasis29.8ALPP, GGT1
15crohn's disease29.8ALB
16intrahepatic cholestasis29.8ABCB4, SLC17A5, GGT1, ALPP
17peritonitis29.8ALB, F2
18hypertension29.8ALB, GGT1, F2
19portal hypertension29.8GPT, F2, SLC17A5, GGT1, ALB
20cholecystolithiasis10.3
21acute cholangitis10.3
22duodenitis10.2
23ascariasis10.0
24schistosomiasis10.0GUSB
25hepatitis e10.0GPT
26gallbladder disease10.0GGT1
27coronary heart disease10.0GGT1
28ovarian cancer10.0GUSB
29hydrops fetalis10.0GUSB
30glucose intolerance10.0GPT
31rheumatoid arthritis10.0GUSB
32alcohol dependence10.0GGT1
33cryoglobulinemia10.0SLC17A5
34substance abuse10.0GGT1
35sarcoma10.0GUSB
36alpha thalassemia10.0UGT1A1
37biliary atresia10.0GGT1, GPT
38stomach cancer10.0GUSB
39wilson disease10.0SLC17A5, GPT
40scrub typhus10.0SLC17A5, GPT
41pyridoxine deficiency10.0GPT, SLC17A5
42pancreatic cancer10.0GUSB, GGT1
43neonatal hemochromatosis10.0SLC17A5, GGT1
44dysgerminoma10.0ALPP
45opisthorchiasis10.0GGT1
46hellp syndrome10.0SLC17A5, GPT
47arthropathy10.0ALPL
48adenoma10.0GGT1
49respiratory failure10.0ALPL
50hyperuricemia10.0GGT1, GPT

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to choledocholithiasis

Clinical Features for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Choledocholithiasis

Drug clinical trials:

Search ClinicalTrials for Choledocholithiasis

Search NIH Clinical Center for Choledocholithiasis

Search CenterWatch for Choledocholithiasis

Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

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32MalaCards
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MalaCards organs/tissues related to Choledocholithiasis:

32
Liver, Testes, Heart

Animal Models for Choledocholithiasis or affiliated genes

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Publications for Choledocholithiasis

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Sources:
50PubMed
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Articles related to Choledocholithiasis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Successful single-session endosonography-based endoscopic retrograde cholangiopancreatography without fluoroscopy in pregnant patients with suspected choledocholithiasis: a case series. (23798477)
2013
2
Robot-assisted common bile duct exploration as an option for complex choledocholithiasis. (22773235)
2013
3
An urban-rural blight? Choledocholithiasis presentation and treatment. (21737099)
2012
4
Is endoscopic ultrasound needed as an add-on test for gallstone diseases without choledocholithiasis on multidetector computed tomography? (22729595)
2012
5
Single-stage treatment with intraoperative ERCP: management of patients with possible choledocholithiasis and gallbladder in situ in a non-tertiary Spanish hospital. (22083324)
2012
6
Endoscopic naso-gallbladder drainage by using cholangioscopy for acute cholecystitis combined with cholangitis or choledocholithiasis (with video). (23078929)
2012
7
Relationship of CA 19-9 with choledocholithiasis and cholangitis. (21796554)
2011
8
Optimal timing of elective laparoscopic cholecystectomy after acute cholangitis and subsequent clearance of choledocholithiasis. (20381787)
2010
9
Therapeutic ERCP for choledocholithiasis in patients 80 years of age and older. (18978507)
2009
10
Patients with a high probability of choledocholithiasis are best managed with ERCP without EUS. (19327495)
2009
11
Highly elevated serum levels of CA 19-9 in choledocholithiasis: a case report. (19829841)
2009
12
Endoscopic/laparoscopic versus open surgical management of choledocholithiasis. (18231854)
2008
13
First case of post-endoscopic retrograde cholangiopancreatography bacteraemia caused by Acinetobacter ursingii in a patient with choledocholithiasis and cholangitis. (18719191)
2008
14
EUS vs MRCP for detection of choledocholithiasis. (16860077)
2006
15
Pylephlebitis associated with acute infected choledocholithiasis. (16909055)
2006
16
Endoscopic papillary balloon dilation with large balloon after limited sphincterotomy for retrieval of choledocholithiasis. (17191309)
2006
17
Endoscopic ultrasonography versus other diagnostic modalities in the diagnosis of choledocholithiasis. (17080253)
2006
18
Choledocholithiasis--a practical approach from the endosonographer. (16802219)
2006
19
Cholangiocarcinoma in the distal bile duct: a probable etiologic association with choledocholithiasis. (16240231)
2005
20
Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. (15667485)
2005
21
Evaluation of the predictors of choledocholithiasis: comparative analysis of clinical, biochemical, radiological, radionuclear, and intraoperative parameters. (16341496)
2005
22
The value of drip infusion cholangiography using multidetector-row helical CT in patients with choledocholithiasis. (15968515)
2005
23
Elevated carbohydrate antigen 19-9 levels in a patient with choledocholithiasis. (12653904)
2003
24
Choledocholithiasis caused by migration of a surgical clip after video laparoscopic cholecystectomy. (12855105)
2003
25
A comparative study of postendoscopic sphincterotomy complications with various types of electrosurgical current in patients with choledocholithiasis. (12556783)
2003
26
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
27
Choledocholithiasis: role of US and endoscopic ultrasound. (11116352)
2001
28
Use of magnetic resonance cholangiography in the diagnosis of choledocholithiasis. (11116354)
2001
29
Laparoscopic common duct exploration in the management of choledocholithiasis. (10930482)
2000
30
Recurrence of biliary symptoms after endoscopic sphincterotomy for choledocholithiasis in patients with gall bladder stones. (10921421)
2000
31
Is choledocholithiasis a late complication of nonresectional therapies for hepatocellular carcinoma? (10626167)
1999
32
Spherocytosis presenting with choledocholithiasis in early childhood: a case report and review of the literature. (19864760)
1999
33
A case report of spherocytosis presenting with choledocholithiasis in early childhood and a review of the literature. (10716037)
1999
34
Laparoscopic cholecystectomy and intraoperative endoscopic sphincterotomy in the treatment of cholecysto-choledocholithiasis. (10502176)
1999
35
Ofuji's papuloerythroderma following choledocholithiasis with secondary sepsis: complete resolution with surgery. (9692313)
1998
36
Laparo-endoscopic "rendezvous": a new technique in the choledocholithiasis treatment. (9840078)
1998
37
Magnetic resonance cholangiography using half-Fourier acquisition for diagnosing choledocholithiasis. (9772049)
1998
38
Choledocholithiasis: evaluation of MR cholangiography for diagnosis. (9807570)
1998
39
Follow-up of more than 10 years after endoscopic sphincterotomy for choledocholithiasis in young patients. (9692563)
1998
40
Choledocholithiasis and gallstone pancreatitis. (9512804)
1997
41
Detection of choledocholithiasis: comparison of unenhanced helical CT and endoscopic retrograde cholangiopancreatography. (9169700)
1997
42
Lipopolysaccharides and beta-glucuronidase activity in choledochal bile in relation to choledocholithiasis. (9383634)
1997
43
A case of retroperitoneal abscess: an unusual complication of cholecystitis and choledocholithiasis. (9640846)
1997
44
The management of choledocholithiasis in children in the era of laparoscopic cholecystectomy. (9247246)
1997
45
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
46
Sequential endoscopic/laparoscopic management of sickle hemoglobinopathy-associated cholelithiasis and suspected choledocholithiasis. (7481984)
1995
47
Intravenous cholangiography and the management of choledocholithiasis prior to laparoscopic cholecystectomy. (7633644)
1995
48
An institutional review of the management of choledocholithiasis in 1616 patients undergoing laparoscopic cholecystectomy. (8129249)
1994
49
Laparoscopic management of choledocholithiasis. (7878505)
1994
50
Treatment of symptomatic choledocholithiasis during pregnancy. (8293907)
1993

Genetic Variations for Choledocholithiasis

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Expression for genes affiliated with Choledocholithiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for genes affiliated with Choledocholithiasis

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Choledocholithiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ALB, GGT1, F2
2
NAD metabolism
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8.9ALPPL2, ALPP, ALPL
38.9ALPL, ALPP, ALPPL2
4
Hide members
6.7ELOVL6, GPT, ABCB4, PNLIPRP1, GGT1, ALPL

Compounds for genes affiliated with Choledocholithiasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Choledocholithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.4GUSB
2lactulose4410.2GUSB, GPT, SLC17A5
3glycyrrhizin44 2811.1GUSB, GPT, SLC17A5
4glycocholate4410.1SLC17A5, ABCB4, GPT, GUSB
5gamma globulin4410.0SLC17A5, GGT1, ALB
6ethyl glucuronide44 2411.0GGT1, UGT1A1, GUSB
7nash4410.0GGT1, GPT, SLC17A5
8d-glucaric acid4410.0GGT1, GUSB
9hepaplastin449.9ALB, SLC17A5, GPT, F2
10nevirapine44 49 1111.9SLC17A5, GGT1, GPT
11aminopyrine449.9SLC17A5, F2, GPT, GGT1
12zidovudine44 1110.8GPT, ALB, SLC17A5, GUSB
13buprenorphine44 28 1111.8GUSB, UGT1A1, SLC17A5
14rifampicin44 28 5911.8GGT1, SLC17A5, GPT, UGT1A1
15mycophenolate mofetil44 49 1111.8UGT1A1, GGT1, GPT, ALB
16naltrexone44 49 28 1112.8SLC17A5, GGT1, UGT1A1
17opium449.8GUSB, SLC17A5
18antipyrine44 1110.7ALB, GGT1, SLC17A5, F2, GUSB
19acetaminophen44 2 49 11 2413.6F2, GGT1, SLC17A5, UGT1A1, GPT
20valproic acid44 49 11 2412.6ALB, GGT1, SLC17A5, GPT, UGT1A1
21tacrolimus44 49 1111.5GGT1, SLC17A5, GPT, ABCB4, ALB
22hyaluronic acid44 2410.5GGT1, GPT, F2, SLC17A5, ALB
23silymarin449.5GPT, F2, GUSB, UGT1A1, GGT1, SLC17A5
24methotrexate44 49 1111.4ABCB4, SLC17A5, F2, GGT1, ALB, GPT
25vitamin b6449.3SLC17A5, ALB, ALPP, ALPL
267,8-dihydroneopterin44 2410.3ALPP, ALPPL2, ALPL
27dihydroneopterin triphosphate44 2410.2ALPP, ALPL, ALPPL2
28dihydroxyacetone44 2410.2ALPP, ALPL, ALPPL2
29pge1449.2GPT, ALPP, SLC17A5, F2, GUSB
30ethanol44 49 11 2412.1ALPL, GGT1, SLC17A5, GPT, GUSB, ALPPL2
31bezafibrate44 28 1111.1ALPP, GPT, GGT1, ABCB4, SLC17A5
32sevoflurane44 1110.1GGT1, ALPP, GPT, SLC17A5, ALB
33isoflurane44 1110.1ALB, ALPP, GGT1, SLC17A5, GPT
34phosphorus449.1SLC17A5, GPT, GGT1, ALPP, ALB
35verapamil44 49 28 11 2413.1ABCB4, ALPP, GGT1, SLC17A5, GPT
36levamisole44 1110.1ALPP, ALPL, ALPPL2
37polyethylene glycol449.1F2, SLC17A5, ALPP, ALB
38simvastatin44 49 59 28 11 2414.1ALPP, SLC17A5, F2, UGT1A1, GPT
39phenytoin44 49 28 1112.0ALB, ALPP, UGT1A1, GGT1, SLC17A5
40phenobarbital44 28 1110.9UGT1A1, SLC17A5, GUSB, ALPP, GGT1, GPT
41vitamin b12448.9GUSB, GGT1, ALPP, SLC17A5, GPT, ALB
42ursodeoxycholic acid44 11 2410.9ABCB4, GPT, F2, SLC17A5, GGT1, ALPP
43pyridoxal 5-phosphate448.9GPT, SLC17A5, GGT1, ALPL, ALPP, ALB
44thyroxine44 249.8UGT1A1, GPT, SLC17A5, GGT1, ALB, ALPP
45lactate448.6SLC17A5, ALB, ALPP, GGT1, F2, GPT
46creatinine448.6ALB, GGT1, SLC17A5, F2, ALPP, GPT
47tamoxifen44 49 28 1111.5F2, ALPP, SLC17A5, GGT1, UGT1A1
48cholesterol44 28 11 2411.5SLC17A5, ALB, UGT1A1, GPT, ABCB4, ALPP
49alanine448.3UGT1A1, GPT, ALB, F2, SLC17A5, ABCB4
50aspartate447.9SLC17A5, GUSB, ALB, ALPP, ALPL, GGT1

GO Terms for genes affiliated with Choledocholithiasis

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16Gene Ontology
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Cellular components related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:0312258.9ALPPL2, ALPP, ALPL
2extracellular spaceGO:0056158.1ALB, ALPL, LGI1, PNLIPRP1, F2, CTRB1

Biological processes related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1ELOVL6, ALB, GGT1, ABCB4, GPT, UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040358.9ALPPL2, ALPP, ALPL

Products for genes affiliated with Choledocholithiasis

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  • Antibodies
  • Proteins
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Sources for Choledocholithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet