MCID: CHL039
MIFTS: 34

Choledocholithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Choledocholithiasis

MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11755
MeSH 42 D042883
UMLS 69 C0701818

Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to acute cholangitis and htra1-related autosomal dominant cerebral small vessel disease. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Lysosome and FOXA2 and FOXA3 transcription factor networks. The drugs Etomidate and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and thyroid.

Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
id Related Disease Score Top Affiliating Genes
1 acute cholangitis 30.0 ABCB4 ALB
2 htra1-related autosomal dominant cerebral small vessel disease 10.7 GPT SLC17A5
3 quinquaud's decalvans folliculitis 10.7 GPT SLC17A5
4 argyria 10.5 F2 GPT
5 campylobacteriosis 10.5 ABCB4 GPT
6 megaloblastic anemia 10.5 GPT SLC17A5
7 maxillary sinusitis 10.5 F2 GPT
8 nonsyndromic hereditary sensorineural hearing loss 10.4 GPT SLC17A5
9 haim-munk syndrome 10.4 CTSC SLC17A5
10 anhidrosis 10.4 ABCB4 CTSC
11 neurogenic thoracic outlet syndrome 10.3 ALPP GPT
12 common cold 10.3 ALB SLC17A5
13 non-hodgkin lymphoma, during pregnancy 10.3 ALB F2
14 cholelithiasis 10.3
15 renal artery disease 10.3 ALB UGT1A1
16 fragile x syndrome type 2 10.3 ALB F2
17 oral cavity carcinoma in situ 10.3 ALB F2
18 duane retraction syndrome 10.3 ALB F2
19 chronic inflammatory demyelinating polyneuritis 10.3 ALB F2
20 bladder sarcoma 10.3 ALB GPT
21 autoimmune disease of cardiovascular system 10.3 ABCB4 ALB
22 angelucci's syndrome 10.3 ALB F2
23 atrophic vulva 10.2 ALB F2
24 late yaws 10.2 ALB SLC17A5
25 cholangitis 10.2
26 acute proliferative glomerulonephritis 10.2 F2 GPT SLC17A5
27 childhood brain stem glioma 10.2 ALB F2
28 myopia 10.2 ALB F2
29 capillary hemangioma 10.2 ALB F2
30 pontocerebellar hypoplasia 10.1 ABCB4 UGT1A1
31 dyskeratosis congenita autosomal recessive 10.1 ALB F2
32 hereditary ataxia 10.1 F2 GPT SLC17A5
33 aryepiglottic fold cancer 10.1 ALB F2
34 pancreatitis 10.1
35 cholecystolithiasis 10.1
36 chronic rheumatic pericarditis 10.1 ABCB4 ALB SLC17A5
37 sex differentiation disease 10.0 ALB ALPP
38 cholecystitis 10.0
39 ischemic heart disease 10.0 ALB F2
40 cutaneous fibrous histiocytoma 10.0 ALB F2 GPT
41 hemolytic-uremic syndrome 10.0 ALB F2 GPT
42 rete ovarii adenoma 10.0 ALB F2 SLC17A5
43 bubonic plague 10.0 ALB F2 GPT
44 spinocerebellar ataxia 8 10.0 ALB F2 GPT
45 mediastinum leiomyoma 10.0 ALB F2
46 alpha 1-antitrypsin deficiency 10.0 ALB F2 SLC17A5
47 eclampsia 10.0 ABCB4 ALPP GPT
48 hemorrhoid 9.9 ABCB4 ALB F2
49 benign mammary dysplasia 9.9 ALB UGT1A1
50 duodenitis 9.9

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis

Symptoms & Phenotypes for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Meperidine Approved Phase 4 57-42-1 4058
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 Adjuvants, Anesthesia Phase 4
6 Analgesics Phase 4
7 Analgesics, Opioid Phase 4
8 Anesthetics Phase 4
9 Anesthetics, General Phase 4
10 Anesthetics, Intravenous Phase 4
11 Anti-Anxiety Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 GABA Agents Phase 4
14 GABA Modulators Phase 4
15 Hypnotics and Sedatives Phase 4
16 Narcotics Phase 4
17 Neurotransmitter Agents Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Psychotropic Drugs Phase 4
20 Tranquilizing Agents Phase 4
21 Cholagogues and Choleretics Phase 4
22 Gastrointestinal Agents Phase 4
23
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
24
Cefotaxime Approved 63527-52-6 456256 5742673
25
Cefoxitin Approved 35607-66-0 441199
26 Plasminogen Early Phase 1
27 Plasminogen Activator Inhibitor 1 Early Phase 1
28 Plasminogen Inactivators Early Phase 1
29 Tissue Plasminogen Activator Early Phase 1
30 glucagon
31 Glucagon-Like Peptide 1
32 Anti-Infective Agents
33 Anti-Infective Agents, Local
34 Chlorhexidine gluconate
35 Disinfectants
36 Anti-Bacterial Agents
37 Antibiotics, Antitubercular
38 Butylscopolammonium Bromide
39 Scopolamine hydrobromide 114-49-8
40 Antitubercular Agents
41 Cephalosporins

Interventional clinical trials:

(show all 41)

id Name Status NCT ID Phase Drugs
1 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
2 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
3 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
4 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
5 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
6 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234
7 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581
8 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
9 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400
10 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
11 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
12 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979
13 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729
14 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686
15 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475
16 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891
17 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
18 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958
19 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552
20 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269
21 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240
22 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845
23 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
24 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
25 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186
26 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
27 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285
28 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286
29 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474
30 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Recruiting NCT03074201
31 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453
32 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
33 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
34 Los Angeles Prospective GI Biliary and EUS Series Recruiting NCT02196935
35 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Enrolling by invitation NCT02647593
36 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Enrolling by invitation NCT02276157
37 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
38 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Not yet recruiting NCT02958059
39 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846
40 Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy Terminated NCT00124033
41 Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance Withdrawn NCT01475864

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

39
Liver, Testes, Thyroid, Heart

Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 626)
id Title Authors Year
1
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
2
The Relationship between Age, Common Bile Duct Diameter and Diagnostic Probability in Suspected Choledocholithiasis. ( 28668951 )
2017
3
Three modalities on management of choledocholithiasis: A prospective cohort study. ( 28668286 )
2017
4
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy: Analysis of a large integrated health care system database. ( 28939251 )
2017
5
Recombinant Factor VIIa Use for Endoscopic Retrograde Cholangiopancreatography With Sphincterotomy in a Patient With Choledocholithiasis and Unusual Coagulopathy. ( 28496540 )
2017
6
Accuracy of ASGE criteria for the prediction of choledocholithiasis. ( 28071059 )
2017
7
Management of choledocholithiasis after previous gastrectomy. ( 28853602 )
2017
8
A prospective evaluation of radiation-free direct solitary cholangioscopy for the management of choledocholithiasis. ( 28797911 )
2017
9
Reappraisal of Endoscopic Papillary Balloon Dilation Versus Sphincterotomy for Choledocholithiasis-Time for a New Trial. ( 28782671 )
2017
10
Cholangiohepatitis With Extensive Intrahepatic Choledocholithiasis. ( 28754269 )
2017
11
Cost analysis of robot-assisted choledochotomy and common bile duct exploration as an option for complex choledocholithiasis. ( 28812193 )
2017
12
Thyrotoxicosis and Choledocholithiasis Masquerading as Thyroid Storm. ( 28912821 )
2017
13
Diagnostic accuracy of EUS compared with MRCP in detecting choledocholithiasis: a meta-analysis of diagnostic test accuracy in head-to-head studies. ( 28645544 )
2017
14
Single Stage Management of Concomitant Cholelithiasis and Choledocholithiasis. ( 28598447 )
2017
15
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
16
Endoscopic Ultrasonography Can Prevent Unnecessary Diagnostic Endoscopic Retrograde Cholangiopancreatography Even in Patients with High Likelihood of Choledocholithiasis and Inconclusive Ultrasonography: Results of a Prospective Study. ( 28793395 )
2017
17
Practice Patterns for Cholecystectomy After Endoscopic Retrograde Cholangiopancreatography for Patients With Choledocholithiasis. ( 28583822 )
2017
18
Transenteric ERCP for Treatment of Choledocholithiasis After Duodenal Switch. ( 28520653 )
2017
19
Primary Closure Following Laparoscopic Common Bile Duct Exploration Combined with Intraoperative Choledochoscopy and D-J Tube Drainage for Treating Choledocholithiasis. ( 28924137 )
2017
20
Choledocholithiasis ( 28722990 )
2017
21
Laparoendoscopic rendez-vous: a safe alternative to the treatment of choledocholithiasis. ( 28731998 )
2017
22
The Efficacy of Clinical Predictors for Patients with Intermediate Risk of Choledocholithiasis. ( 27640085 )
2016
23
Endoscopic management of choledocholithiasis and cholelithiasis in patients with cirrhosis. ( 26799755 )
2016
24
Nationwide Assessment of Trends in Choledocholithiasis Management in the United States From 1998 to 2013. ( 27556900 )
2016
25
Prospective Evaluation of the Clinical Features of Choledocholithiasis: Focus on Abdominal Pain. ( 27135724 )
2016
26
Endoscopic ultrasonography versus magnetic resonance cholangiopancreatography for suspected choledocholithiasis: Comments from the radiologists'. ( 27080612 )
2016
27
The Usefulness of Early Endoscopic Ultrasonography in Acute Biliary Pancreatitis with Undetectable Choledocholithiasis on Multidetector Computed Tomography. ( 27780944 )
2016
28
A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis. ( 27031649 )
2016
29
A scoring system for the prediction of choledocholithiasis: a prospective cohort study. ( 26922689 )
2016
30
Use of an esophageal stent for successful treatment of significant choledocholithiasis to facilitate direct cholangioscopy. ( 27102830 )
2016
31
Scoring system to preoperatively predict choledocholithiasis. ( 27146040 )
2016
32
Single-stage management with combined tri-endoscopic approach for concomitant cholecystolithiasis and choledocholithiasis. ( 27126621 )
2016
33
Surgical Management of Choledocholithiasis: A Disappearing Skill. ( 27556413 )
2016
34
Role of laparoscopic common bile duct exploration in the management of choledocholithiasis. ( 27231516 )
2016
35
Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis: Prospective comparative study. ( 27759652 )
2016
36
Ultrathin choledochoscope improves outcomes in the treatment of gallstones and suspected choledocholithiasis. ( 27796141 )
2016
37
Endoscopic versus laparoscopic treatment for choledocholithiasis: a prospective randomized controlled trial. ( 27857966 )
2016
38
Commentary on "Prospective Evaluation of the Clinical Features of Choledocholithiasis: Focus on Abdominal Pain". ( 27135725 )
2016
39
The utility and yield of endoscopic ultrasonography for suspected choledocholithiasis in common gastroenterology practice. ( 27556688 )
2016
40
Re: Endoscopic large balloon sphincteroplasty is a useful, safe adjunct for difficult to treat choledocholithiasis. ( 27910279 )
2016
41
Severe Elevation of Liver Tests in Choledocholithiasis: An Uncommon Occurrence With Important Clinical Implications. ( 27466169 )
2016
42
Prevalence of Cholelithiasis and Choledocholithiasis in Morbidly Obese South Indian Patients and the Further Development of Biliary Calculus Disease After Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass. ( 26910024 )
2016
43
Choledocholithiasis Without Cholelithiasis: Should the Gallbladder Stay or Should It Go? ( 26738738 )
2016
44
Accuracy of ASGE criteria for the prediction of choledocholithiasis. ( 27063334 )
2016
45
Safety of immediate endoscopic sphincterotomy in acute suppurative cholangitis caused by choledocholithiasis. ( 26862368 )
2016
46
Laparoscopic Common Bile Duct Exploration Versus Open Approach in Cirrhotic Patients with Choledocholithiasis: A Retrospective Study. ( 27509535 )
2016
47
Advances of recurrent risk factors and management of choledocholithiasis. ( 27610642 )
2016
48
Automated development of artificial neural networks for clinical purposes: Application for predicting the outcome of choledocholithiasis surgery. ( 27261565 )
2016
49
Same-day laparoscopic cholecystectomy and ERCP for choledocholithiasis. ( 27633358 )
2016
50
Feasibility of nonradiation EUS-based ERCP in patients with uncomplicated choledocholithiasis (with video). ( 27040099 )
2016

Variations for Choledocholithiasis

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for Choledocholithiasis

Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.89 CTSC GUSB SLC17A5
2 10.6 ALB F2

GO Terms for Choledocholithiasis

Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 ALB CTSC F2

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to estradiol stimulus GO:0071392 9.16 ABCB4 UGT1A1
2 acute-phase response GO:0006953 8.96 F2 UGT1A1
3 response to organic substance GO:0010033 8.8 ABCB4 CTSC UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Choledocholithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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