Cholelithiasis malady

Wikipedia: A gallstone is a crystalline concretion formed within the gallbladder by accretion of bile components....⁴⁴ more...

MalaCards: Cholelithiasis is related to choledocholithiasis and gilbert syndrome. An important gene associated with Cholelithiasis is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Pentose and glucuronate interconversions and ABC transporters. The drug ursodiol and the compounds glucose and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, liver and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

cholelithiasis 6 8 32 43

Diseases related to cholelithiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 552)

id	Related Disease	Score	Top Affiliating Genes
1	choledocholithiasis	29.5	UGT1A1, GUSB, GPT, ABCB4, SLC17A5, GGT1
2	gilbert syndrome	28.9	UGT1A1, UGT1A6, UGT2B4, CD40LG, HMOX1, G6PD
3	beta thalassemia	28.3	HBA2, HBB, HFE
4	carcinoid tumors	27.9	VIP, CHGA, CDX2, CCK, SST, PSG2
5	alpha thalassemia	27.8	UGT1A1, HP, G6PD, HBA2, HBB, HFE
6	alcoholism	27.4	CCK, CCKAR, GPT, HMGCR, G6PD, SLC17A5
7	hepatitis	27.2	GUSB, GPT, F2, HFE, SLC17A5, GGT1
8	myotonic dystrophy type 1	27.1	CD40LG, AR, MBNL1, ADIPOQ
9	sickle cell anemia	26.9	BPGM, UGT1A1, CD79A, CD40LG, GUSB, GPT
10	thalassemia	26.1	UGT1A1, INS, GPT, GP1BA, F2, HP
11	myotonic dystrophy	25.9	CD40LG, AR, INS, APOE, MBNL1, ADIPOQ
12	liver cirrhosis	25.7	VIP, GPT, GP1BA, F2, SST, ABCB11
13	sickle cell disease	24.0	UGT1A1, GUSB, INS, APOA1, APOE, GPT
14	cholestasis	22.9	APOE, ANPEP, CCK, GPT, F2, ESR1
15	anemia	22.4	BPGM, CHGA, UGT1A1, CD79A, CD40LG, GUSB
16	duodenitis	20.5	VIP, CHGA, UGT1A1, UGT1A6, UGT2B4, MUC2
17	cholesterol	18.6	VIP, LPXN, SCARB1, CHGA, UGT1A1, UGT1A6
18	obesity	16.7	VIP, LPXN, SCARB1, CHGA, CD79A, AR
19	crigler najjar syndrome, type 2	13.8	UGT1A1, UGT1A6, GPT
20	extrahepatic cholestasis	13.8	GPT, CYP7A1, GGT1
21	crigler-najjar syndrome	13.8	UGT1A1, UGT1A6, GPT
22	intestinal neuroendocrine tumor	13.8	CHGA, CDX2, SST
23	gallbladder disease	13.7	MUC2, CCK, CCKAR
24	bile reflux	13.7	CDX2, CCK, GAST
25	acalculous cholecystitis	13.7	CD40LG, GUSB, CCK
26	pancreatic cholera	13.7	VIP, SST, GAST
27	glucosephosphate dehydrogenase deficiency	13.6	UGT1A1, HP, G6PD
28	digestive diseases	13.6	GPT, NR1H2, ABCB4, PSG2, GGT1
29	microinvasive gastric cancer	13.6	MUC2, CDX2, PSG2, GAST
30	hereditary pancreatitis	13.6	SERPINB5, UGT1A1, MUC2, CCK, SST, PSG2
31	macrothrombocytopenia	13.6	GP1BA, ABCG5, ABCG8
32	hemoglobin constant spring	13.6	HBA2, HBB
33	aortic atherosclerosis	13.5	SCARB1, APOE, ABCG5, ABCG8
34	endocrine gland cancer	13.5	VIP, CHGA, SST, GAST
35	neuroendocrine carcinoma	13.5	CHGA, CDX2, SST, GAST
36	somatostatinoma	13.5	VIP, CHGA, SST, GAST
37	hereditary spherocytosis	13.5	UGT1A1, G6PD, HFE
38	vipoma	13.5	VIP, CHGA, SST, GAST
39	zollinger-ellison syndrome	13.5	CHGA, SST, GAST
40	constipation	13.5	VIP, CHGA, GUSB, CCK, SST, GGT1
41	pyruvate kinase deficiency	13.5	G6PD, HBA2, HFE
42	ovarian mucinous neoplasm	13.5	SERPINB5, CHGA, MUC2, CDX2, SST, PSG2
43	familial medullary thyroid carcinoma	13.5	CHGA, CCK, CCKAR, SST, PSG2, GAST
44	obstructive jaundice	13.5	CCK, GPT, PSG2, SLC17A5, GGT1
45	cholestasis, progressive familial intrahepatic 1	13.5	NR1H4, ABCB11, ABCB4, SLC10A2, GGT1
46	gastroesophageal reflux disease	13.5	CDX2, CCK, CCKAR, HP, GAST
47	protein-energy malnutrition	13.5	CD79A, CCK, GPT, HP, GGT1
48	steatorrhea	13.4	CCK, SST, SLC10A2
49	drug-induced hepatitis	13.4	UGT1A1, UGT1A6, GPT, SLC17A5
50	cetp deficiency	13.4	SCARB1, APOA1, APOE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 ursodiol

MalaCards organs/tissues related to cholelithiasis:

²²

MGI Mouse Phenotypes related to cholelithiasis:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.5	GP1BA, SULT1E1
2	endocrine/exocrine gland phenotype	MP:0005379	10.2	GGT1, CCKAR, GUSB, CDX2, CD40LG
3	integument phenotype	MP:0010771	8.8	HBB, HBA2, CYP7A1, F2, IL4, IL1R1
4	reproductive system phenotype	MP:0005389	8.2	NR1H2, ABCB4, ABCG5, HBB, ADIPOQ, SULT1E1
5	immune system phenotype	MP:0005387	8.1	HBB, HFE, ADIPOQ, GAST, GGT1, ABCG5
6	renal/urinary system phenotype	MP:0005367	7.8	HAL, HBB, ESR2, ESR1, CCKAR, APOE
7	skeleton phenotype	MP:0005390	7.8	HBB, NR1H2, ESR2, ESR1, IL1R1, INS
8	tumorigenesis	MP:0002006	7.4	GAST, ADIPOQ, ABCB4, PPARGC1A, ESR2, ESR1
9	liver/biliary system phenotype	MP:0005370	7.4	SLC10A2, AR, INS, IL1R1, HBB, ABCG8
10	growth/size phenotype	MP:0005378	7.4	PPARGC1A, HBA2, HBB, HFE, SLC10A2, ADIPOQ
11	adipose tissue phenotype	MP:0005375	7.2	ADIPOQ, PPARGC1A, ESR2, ESR1, APOE, IL1R1
12	muscle phenotype	MP:0005369	7.0	PPARGC1A, NR1H2, ABCG5, HBA2, HMOX1, ESR2
13	mortality/aging	MP:0010768	6.5	PPARGC1A, NR1H4, ABCG5, G6PD, HBA2, HFE
14	normal phenotype	MP:0002873	6.4	ESR2, HMGCR, SST, NR1H2, HBB, HFE
15	digestive/alimentary phenotype	MP:0005381	5.9	SST, PPARGC1A, ABCB4, ABCG5, ABCG8, HFE
16	behavior/neurological phenotype	MP:0005386	5.7	SST, PPARGC1A, NR1H2, ABCG5, ELOVL6, HFE
17	cardiovascular system phenotype	MP:0005385	4.9	ESR1, ESR2, HMOX1, PPARGC1A, NR1H2, ABCB4
18	cellular phenotype	MP:0005384	3.5	PPARGC1A, HMOX1, ESR2, ESR1, HP, NR1H2
19	homeostasis/metabolism phenotype	MP:0005376	1.5	GGT1, GAST, HAL, ADIPOQ, SLC10A2, SLC17A5

Articles related to cholelithiasis:

(show top 50)    (show all 54)

id	Title	Authors	Year	Affiliating Genes
1	Cholelithiasis, cholecystectomy, and liver disease. (20068558)	Ioannou G.N.	2010	GGT1
2	Cholelithiasis in thalassemia major. (19021734)	Origa R.... Piga A.	2009	UGT1A1
3	Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. (19309288)	Tsezou A.... Kitsiou-Tzeli S.	2009	UGT1A1
4	APOE gene polimorphism and lithogenicity of the bile in the women with cholelithiasis (20469680)	Grigor'eva I.N.... Voevoda M.I.	2009	APOE
5	The timing of laparoscopic cholecystectomy after endo scopic retrograde cholangiopancreaticography in cholelithiasis coexisting with choledocholithiasis. (19701600)	Salman B.... Tatlicioglu E.	2009	SLC17A5
6	Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder. (18440760)	Svoboda M.... Thalhammer T.	2008	SULT1E1, STS
7	The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. (17593033)	Vasavda N.... Thein S.L.	2007	HMOX1, UGT1A1
8	Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations. (17384433)	Mella J.G.... Miquel J.F.	2007	APOE
9	A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis. (16996572)	Sakamoto H.... Sugano K.	2007	CHGA, MUC2, CDX2
10	Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene. (17562004)	Rosmorduc O.... Poupon R.	2007	GGT1, ABCB4
11	Steroid hormones polymorphisms and cholelithiasis in Greek population. (17241382)	Kitsiou-Tzeli S.... Tsezou A.	2007	AR, ESR1, ESR2
12	Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis. (16505288)	Maesawa C.... Masuda T.	2006	SERPINB5
13	Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. (16506961)	Bertolotti M.... Carulli N.	2006	NR1H2, PPARGC1A
14	Serum adiponectin levels in cholesterol and pigment cholelithiasis. (16739100)	Wang S.N.... Lee K.T.	2006	ADIPOQ
15	Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. (16237771)	Huang Y.Y.... Huang C.S.	2005	G6PD, UGT1A1
16	The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis (16083600)	Zhuang X.M.... Zhang Y.	2005	IL4
17	Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia. (15710570)	Chaar V.... Romana M.	2005	UGT1A1
18	Low density lipoproteins in patients with cholelithiasis and cholesterosis of the gallbladder (15807442)	Ivanchenko R.A.... Shchel'tsina N.V.	2005	LPXN
19	Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children. (14555319)	Kitsiou-Tzeli S.... Tsezou A.	2003	UGT1A1
20	Polymorphism in transmembrane region of MICA gene and cholelithiasis. (12854159)	Shih S.C.... Kao C.R.	2003	MICA
21	ABCB4 gene mutation-associated cholelithiasis in adults. (12891548)	Rosmorduc O.... Poupon R.	2003	ABCB4
22	A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. (12671900)	Lucena J.-F.... Prieto J.	2003	GGT1, ABCB4
23	Apolipoprotein-E genotype and the risk of developing cholelithiasis following bariatric surgery: a clue to prevention of routine prophylactic cholecystectomy. (12087994)	Abu Abeid S.... Konikoff F.M.	2002	APOE
24	Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphism. (12572876)	Miyasaka K.... Funakoshi A.	2002	CCKAR, CCK
25	MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. (11313316)	Rosmorduc O.... Poupon R.	2001	ABCB4
26	Hamsters predisposed to sucrose-induced cholesterol gallstones (LPN strain) are more resistant to excess dietary cholesterol than hamsters that are not sensitive to cholelithiasis induction. (11385071)	Souidi M.... Lutton C.	2001	CYP27A1
27	Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. (11878580)	Passon R.G.... Ware R.E.	2001	UGT1A1
28	Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis. (11108738)	FAcrAczou J.... Lutton C.	2000	CYP27A1
29	Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide. (10923237)	Radetti G.... Messner H.	2000	SST
30	Minimal access surgery for cholelithiasis induces an attenuated acute phase response. (10527445)	Bruce D.M.... Eremin O.	1999	IL1R1
31	Asymptomatic cholelithiasis: indications for cholecystectomy based on the levels of acute phase proteins (10793766)	Tarocco R.... Meo G.	1999	CD40LG, CD79A, HP
32	The pathogenesis of liver functional disorders after cholecystectomy in cholelithiasis (10222554)	Aksenova E.M.... Vakhrushev I.a.M.	1999	INS, GAST
33	Influence of alpha-thalassemia on cholelithiasis in SS patients with elevated Hb F. (9858792)	Haider M.Z.... Adekile A.D.	1998	HBA2
34	Alpha-L-fucosidase activity in patients with ductal cholelithiasis (9695655)	Sztefko K.... Szafran Z.	1998	GGT1
35	Different pathways mediate cholecystokinin actions in cholelithiasis. (9142916)	Chen Q.... Behar J.	1997	CCK
36	Study of the secretion of substance P, neurotensin and somatostatin in patients with cholelithiasis. (9253232)	Ortega LA^pez D.... Alvarez FernA!ndez-Represa J.	1997	SST
37	Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)	Onken J.E.... Cotton P.B.	1996	SLC17A5
38	Prevalence of cholelithiasis according to alcoholic liver disease: a possible role of apolipoproteins AI and AII. (7771667)	Poynard T.... Chaput J.C.	1995	APOA1
39	Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. (7555451)	Ho K.J.... Wu C.Z.	1995	GUSB
40	Intrahepatic biliary cholesterol and phospholipid transport in humans: effect of obesity and cholesterol cholelithiasis. (8847482)	Ahmed H.A.... Northfield T.C.	1995	HMGCR
41	Laparoscopic cholecystectomy for cholelithiasis in patients with liver cirrhosis. (18493357)	Ishikawa T.... Nishiguchi Y.	1995	F2
42	Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis. (7590442)	NA_A+ez L.... Garrido J.	1995	ANPEP
43	Cholelithiasis during pregnancy and lactation. Prospective study. (7532015)	Tsimoyiannis E.C.... Papanikolaou N.	1994	GPT
44	Surgery in the elderly: observations on the pathophysiology and treatment of cholelithiasis. (8224042)	Rosenthal R.A.... Andersen D.K.	1993	CCK
45	Cholelithiasis associated with medroxyprogesterone acetate therapy in men. (1385654)	Meyer W.J.... Thompson J.C.	1992	CCK
46	The bacteriology of cholelithiasis--China versus Japa n. (1787607)	Guo R.X.... Shen K.	1991	GUSB
47	Chronic treatment with a long-acting somatostatin analogue in a patient with intestinal carcinoid tumor: occurrence of cholelithiasis. (2319110)	Roti E.... Braverman L.E.	1990	VIP
48	Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla (2278184)	Pugachev A.V.... Rodzhiashvili Z.U.	1990	SST
49	Effect of yiqi-yangyin prescription on bile composit ion of cholelithiasis patients (2208433)	Wei D.Q.	1990	GUSB
50	Biochemical studies and biopsy examination in the evaluation of liver function in cholelithiasis (896549)	Markert R.	1977	HFE

Genes related to cholelithiasis according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	11.0	Publications
2	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
3	LPXN	leupaxin	11.0	Publications
4	GUSB	glucuronidase, beta	11.0	Publications
5	CCK	cholecystokinin	11.0	Publications
6	GGT1	gamma-glutamyltransferase 1	11.0	Publications
7	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0
8	SST	somatostatin	11.0	Publications
9	SCARB1	scavenger receptor class B, member 1	11.0
10	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
11	MARS2	methionyl-tRNA synthetase 2, mitochondrial	11.0
12	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	11.0	Publications
13	HAL	histidine ammonia-lyase	11.0	Publications
14	BPGM	2,3-bisphosphoglycerate mutase	11.0
15	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	11.0	Publications
16	UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	11.0
17	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	11.0	Publications
18	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
19	HBA2	hemoglobin, alpha 2	11.0	Publications
20	CDX2	caudal type homeobox 2	11.0	Publications
21	ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	11.0
22	ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	11.0
23	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	11.0
24	CCKAR	cholecystokinin A receptor	11.0	Publications
25	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	11.0
26	CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	11.0
27	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
28	MBNL1	muscleblind-like splicing regulator 1	11.0	Publications
29	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
30	STS	steroid sulfatase (microsomal), isozyme S	11.0	Publications
31	HP	haptoglobin	11.0	Publications
32	ELOVL6	ELOVL fatty acid elongase 6	11.0
33	VIP	vasoactive intestinal peptide	11.0	Publications
34	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
35	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	11.0	Publications
36	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0
37	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
38	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	11.0
39	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0
40	GAST	gastrin	11.0	Publications
41	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
42	HBB	hemoglobin, beta	11.0
43	HFE	hemochromatosis	11.0	Publications
44	IL1R1	interleukin 1 receptor, type I	11.0	Publications
45	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
46	CD40LG	CD40 ligand	11.0	Publications
47	APOE	apolipoprotein E	11.0	Publications
48	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
49	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
50	APOA1	apolipoprotein A-I	11.0	Publications

Pathways related to cholelithiasis according to GeneDecks:

(show all 12)

id	Pathway	Score	Top Affiliating Genes
1	Pentose and glucuronate interconversions20	10.3	UGT1A1, UGT1A6, UGT2B4, GUSB
2	ABC transporters20	10.1	ABCG8, ABCG5, ABCB4, ABCB11
3	Steroid hormone biosynthesis20	10.1	STS, CYP7A1, SULT1E1, UGT2B4, UGT1A6, UGT1A1
4	Drug metabolism - other enzymes20	10.1	GUSB, UGT2B4, UGT1A6, UGT1A1
5	Porphyrin and chlorophyll metabolism20	10.0	HMOX1, GUSB, UGT2B4, UGT1A6, UGT1A1
6	Fat digestion and absorption20	9.9	SCARB1, APOA1, ABCG5, ABCG8
7	Starch and sucrose metabolism20	9.9	UGT1A1, UGT1A6, UGT2B4, GUSB
8	Selected targets of CREB110	9.5	INS, CCK, HMGCR
9	Statin Pathway, Pharmacodynamics34	9.4	ABCG8, ABCG5, CYP7A1, HMGCR, APOE, APOA1
10	Bile secretion20	9.3	SCARB1, SLC10A2, ABCG8, ABCG5, ABCB4, ABCB11
11	Metabolism of lipids and lipoproteins38	9.3	GGT1, SLC10A2, STS, ELOVL6, ABCG8, ABCG5
12	Metabolic pathways20	9.1	CYP7A1, CYP27A1, G6PD, HAL, GGT1, HMGCR

Compounds related to cholelithiasis according to GeneDecks:

(show top 50)    (show all 330)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.4	GAST, PSG2, GP1BA
2	chenodeoxycholic acid32 9 18 9	12.5	CCK, GPT, HMGCR, CYP7A1, CYP27A1, NR1H2
3	rifampicin32	9.5	GGT1, UGT1A1, UGT1A6, GPT, HP, PPARGC1A
4	polyethylene glycol32	9.3	VIP, APOA1, APOE, ANPEP, HP, HMOX1
5	acetaminophen32 34 9 18 9	13.1	UGT2B4, GGT1, SLC17A5, G6PD, F2, GPT
6	vitamin b1232	9.1	CD79A, CD40LG, GUSB, APOA1, APOE, HP
7	taurocholate32	9.0	SCARB1, APOA1, CCK, HMGCR, CYP7A1, NR1H2
8	ascorbic acid32 18	10.0	CD40LG, AR, IL1R1, G6PD, SLC17A5, GAST
9	phenobarbital32 9 9	11.0	GUSB, NR1H2, HMOX1, GPT, APOA1, UGT1A1
10	cysteine32	8.8	ABCB11, ESR2, CDX2, CD40LG, MUC2, HBB
11	bezafibrate32 9 9	10.4	INS, APOA1, APOE, GPT, HMGCR, CYP7A1
12	progesterone32 42 9 18 9	12.4	UGT2B4, AR, ANPEP, ESR1, ESR2, SULT1E1
13	dopamine32 9 18 9	11.4	ESR2, CCKAR, CCK, GUSB, CD40LG, CD79A
14	aspartate32	8.3	VIP, CD40LG, GUSB, APOA1, APOE, ANPEP
15	creatinine32	8.3	HP, HMGCR, G6PD, PSG2, ADIPOQ, GGT1
16	ezetimibe32 9 9	10.3	GPT, HMGCR, NR1H2, ABCG5, ABCG8, SLC17A5
17	glutamate32	8.3	HBB, ESR2, SST, NR1H2, IL1R1, ANPEP
18	sterol32	8.3	SCARB1, APOA1, APOE, HMGCR, CYP7A1, CYP27A1
19	pge232	8.2	HMOX1, APOA1, IL1R1, AR, VIP, SST
20	uric acid32 18	9.2	GPT, G6PD, SLC17A5, ADIPOQ, GGT1, HFE
21	n acetylcysteine32	8.2	IL1R1, APOE, GPT, F2, HMGCR, SLC17A5
22	ursodeoxycholic acid32 9 18 9	11.2	ABCB4, SLC17A5, SLC10A2, GGT1, ABCB11, NR1H4
23	fenofibrate32 9 9	10.2	INS, CD40LG, APOA1, ADIPOQ, SLC17A5, NR1H2
24	atorvastatin32 34 9 18 9	12.1	HMOX1, GPT, APOE, APOA1, CD40LG, CYP7A1
25	alpha tocopherol32	8.0	SCARB1, IL4, APOA1, APOE, HMOX1, HMGCR
26	epinephrine32 9 18 9	10.9	VIP, CHGA, CD79A, INS, GP1BA, F2
27	rosiglitazone32 9 18 9	10.6	SCARB1, HMOX1, INS, IL1R1, APOE, ADIPOQ
28	estrone32 9 18 9	10.5	UGT1A6, UGT2B4, ADIPOQ, STS, NR1H2, SULT1E1
29	simvastatin32 34 42 9 18 9	12.3	HMGCR, CYP27A1, F2, GPT, APOE, APOA1
30	tamoxifen32 34 9 9	10.2	SULT1E1, NR1H2, ABCB11, G6PD, STS, SLC17A5
31	dihydrotestosterone32 9 18 9	10.1	ESR2, ADIPOQ, VIP, NR1H2, STS, UGT2B4
32	methotrexate32 34 42 9 9	11.1	CD79A, MUC2, IL1R1, GPT, F2, ESR1
33	vitamin d32	7.0	AR, APOE, IL1R1, GPT, GAST, NR1H2
34	aspirin32 34 18	8.9	F2, HP, HMOX1, HMGCR, G6PD, ADIPOQ
35	adenylate32	6.9	CHGA, CD40LG, IL1R1, IL4, ESR2, GPT
36	cyclosporin a32 42	7.9	SLC17A5, CD79A, CD40LG, IL1R1, IL4, APOE
37	testosterone32 9 18 9	9.7	VIP, SCARB1, CHGA, UGT1A1, UGT1A6, UGT2B4
38	alanine32	6.7	ABCB4, SLC17A5, ADIPOQ, GAST, GGT1, HFE
39	steroid32	6.7	SERPINB5, SCARB1, STS, HBB, ABCB11, CHGA
40	thyroxine32 18	7.3	GAST, GGT1, ADIPOQ, SLC17A5, G6PD, VIP
41	actinomycin d32	5.9	ADIPOQ, HMOX1, G6PD, HMGCR, ESR2, ABCB11
42	lactate32	5.9	VIP, PSG2, SLC17A5, ADIPOQ, GGT1, HBB
43	cholesterol32 9 18 9	8.8	LPXN, SCARB1, CHGA, UGT1A1, MUC2, INS
44	lipid32	5.7	SLC17A5, SLC10A2, ADIPOQ, GGT1, PSG2, APOE
45	vegf32	5.6	NR1H2, AR, SERPINB5, VIP, CHGA, CD79A
46	retinoic acid32 42 18	7.5	SST, PPARGC1A, NR1H2, NR1H4, ABCB11, STS
47	arginine32	5.2	VIP, CHGA, UGT1A1, CD79A, CD40LG, AR
48	serine32	4.9	GP1BA, ANPEP, F2, HP, ESR2, IL1R1
49	dexamethasone32 42 34 9 9	8.6	VIP, CHGA, UGT1A1, MUC2, CD79A, CD40LG
50	estrogen32	3.2	SERPINB5, VIP, SCARB1, CHGA, UGT1A1, UGT2B4

Cellular components related to cholelithiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin-hemoglobin complex	GO:031838	9.9	HBB, HBA2, HP
2	integral to plasma membrane	GO:005887	8.2	SLC10A2, SLC17A5, HFE, ABCB4, ABCB11, GP1BA
3	extracellular region	GO:005576	7.0	HP, ESR2, SST, PSG2, ADIPOQ, F2
4	extracellular space	GO:005615	6.7	SERPINB5, ADIPOQ, SST, HMOX1, HP, F2

Biological processes related to cholelithiasis according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of intestinal cholesterol absorption	GO:045796	10.3	ABCG8, ABCG5
2	xenobiotic metabolic process	GO:006805	10.2	GGT1, CYP27A1, CYP7A1, SULT1E1, UGT2B4, UGT1A6
3	digestion	GO:007586	10.2	PPARGC1A, SST, CCKAR, UGT1A1
4	negative regulation of intestinal phytosterol absorption	GO:010949	10.2	ABCG8, ABCG5
5	bile acid metabolic process	GO:008206	10.1	SLC10A2, ABCB11, NR1H4, CYP27A1, CYP7A1
6	high-density lipoprotein particle clearance	GO:034384	10.1	SCARB1, APOA1, APOE
7	bile acid biosynthetic process	GO:006699	10.1	CYP7A1, CYP27A1, ABCB11
8	positive regulation of cell death	GO:010942	10.1	HP, HBA2, HBB
9	high-density lipoprotein particle remodeling	GO:034375	10.0	APOE, APOA1, SCARB1
10	reverse cholesterol transport	GO:043691	10.0	SCARB1, APOA1, APOE
11	cholesterol efflux	GO:033344	10.0	ABCG8, ABCG5, APOE, APOA1, SCARB1
12	endothelial cell proliferation	GO:001935	10.0	HMOX1, APOA1, SCARB1
13	response to hydrogen peroxide	GO:042542	10.0	HP, HMOX1, HBA2, HBB
14	low-density lipoprotein particle clearance	GO:034383	9.9	SCARB1, HMOX1, ADIPOQ
15	cholesterol homeostasis	GO:042632	9.8	ABCG8, ABCG5, CYP7A1, APOE, APOA1, SCARB1
16	positive regulation of cholesterol efflux	GO:010875	9.8	ADIPOQ, NR1H2, APOE
17	lipid metabolic process	GO:006629	9.7	G6PD, ABCG8, ABCG5, ABCB4, APOE, APOA1
18	female pregnancy	GO:007565	9.6	PSG2, STS, HFE, SULT1E1, IL4
19	cellular lipid metabolic process	GO:044255	9.6	ELOVL6, ABCB4, NR1H2, CYP7A1, HMGCR, APOA1
20	positive regulation of cellular protein metabolic process	GO:032270	9.6	ADIPOQ, NR1H2, INS
21	positive regulation of nitric-oxide synthase activity	GO:051000	9.1	ESR1, APOE, INS, SCARB1
22	response to nutrient	GO:007584	9.0	ADIPOQ, ABCG5, SST, HMGCR, CCKAR, IL4
23	cholesterol metabolic process	GO:008203	8.9	IL4, APOA1, APOE, CYP27A1
24	transcription initiation from RNA polymerase II promoter	GO:006367	8.6	NR1H4, NR1H2, PPARGC1A, ESR2, ESR1, AR
25	small molecule metabolic process	GO:044281	6.9	SCARB1, ABCB4, ABCG5, ABCG8, ELOVL6, G6PD

Molecular functions related to cholelithiasis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	retinoic acid binding	GO:001972	10.2	UGT1A1, UGT1A6, UGT2B4
2	haptoglobin binding	GO:031720	10.1	HBB, HBA2
3	cholesterol transporter activity	GO:017127	10.0	APOA1, ABCG5, ABCG8
4	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.5	NR1H4, NR1H2, ESR2, AR
5	steroid binding	GO:005496	9.4	SULT1E1, ESR2, ESR1, UGT1A1
6	heme binding	GO:020037	9.3	HMOX1, CYP7A1, CYP27A1, HBA2, HBB
7	hormone activity	GO:005179	9.2	VIP, INS, CCK, SST, ADIPOQ, GAST
8	steroid hormone receptor activity	GO:003707	9.0	NR1H4, NR1H2, ESR2, ESR1
9	enzyme binding	GO:019899	8.3	HMOX1, ESR2, ESR1, APOA1, AR, UGT1A6