MCID: CHL004
MIFTS: 51

Cholelithiasis malady

Summaries for Cholelithiasis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are nicotine degradation III and thyroid hormone metabolism II (via conjugation and/or degradation). The drug ursodiol and the compounds sn38 glucuronide and lamotrigine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Cholelithiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cholelithiasis 8 10 44 60


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Disease Ontology8 DOID:10211
ICD9CM27 574.5
MeSH34 D002769

Related Diseases for Cholelithiasis

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17GeneCards, 18GeneDecks
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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis30.9GPT, CCK
2choledocholithiasis30.7GUSB, GPT, GGT1
3pancreatitis30.5CCKAR, CCK, UGT1A7, SST, ABCB4, GGT1
4hepatitis30.5GUSB, GPT, GGT1
5cholestasis30.4GGT1, ABCB4, GPT, CCK
6liver cirrhosis30.4GGT1, GPT, GUSB
7obesity30.3CCKAR, CCK, SCARB1, GPT, GGT1
8acute pancreatitis30.2CCKAR, CCK, PSG2, SST, GPT
9cholangitis30.2GPT, ABCB4, GGT1
10gallbladder disease30.2CCKAR, CCK
11gallbladder cancer30.1CDX2, PSG2
12pancreatic cancer30.1CCKAR, CCK, SST, CDX2, SERPINB5
13gilbert syndrome29.9UGT1A4, UGT1A1, UGT1A7
14adenoma29.9PSG2, SCARB1, SST, CDX2, GGT1, SERPINB5
15adenocarcinoma29.9CCKAR, CCK, PSG2, GUSB, UGT1A1, UGT1A7
16esophagitis29.7CDX2
17alpha thalassemia29.7UGT1A1
18atherosclerosis29.7SCARB1, LPXN, GGT1
19obstructive jaundice29.7CCK, PSG2, GPT, GGT1
20bile reflux29.7CCK
21prostate cancer29.7SERPINB5, CDX2
22colon cancer29.7CCKAR, PSG2, GUSB, UGT1A1, UGT1A10, CDX2
23breast cancer29.7PSG2, UGT1A1, CDX2, ABCB4, SULT1E1, SERPINB5
24colorectal cancer29.7PSG2, GUSB, CDX2, SERPINB5
25sickle cell disease10.3
26gallbladder disease 110.3
27liver disease10.2
28hiatus hernia10.2
29thalassemia10.2
30sickle cell anemia10.1
31hereditary spherocytosis10.1
32ascariasis10.1
33appendicitis10.1
34situs inversus10.1
35choledochal cyst10.1
36down syndrome10.1
37hyperparathyroidism10.1
38myotonic dystrophy10.1
39cystic fibrosis10.0GUSB
40constipation10.0CCK
41familial adenomatous polyposis10.0CDX2
42diarrhea10.0UGT1A1, SST
43anorexia nervosa10.0CCK
44protein-energy malnutrition10.0CCK
45pituitary adenoma10.0SST
46coronary heart disease10.0GGT1, SCARB1
47dyspepsia10.0CCK
48crigler najjar syndrome, type 210.0UGT1A4, UGT1A1
49endometrial carcinoma10.0SULT1E1, PSG2
50crigler-najjar syndrome10.0UGT1A4, UGT1A1

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Clinical Features for Cholelithiasis

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Drugs & Therapeutics for Cholelithiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholelithiasis

Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

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Search CenterWatch for Cholelithiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cholelithiasis

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Anatomical Context for Cholelithiasis

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32MalaCards
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MalaCards organs/tissues related to Cholelithiasis:

32
Liver, Heart, Kidney, Colon, Pancreas, Testes, Prostate, Ovary, Breast, Bone marrow, Small intestine, Smooth muscle, Spinal cord, Bone, B cells

Animal Models for Cholelithiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholelithiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1SULT1E1, ABCB4, CDX2, GUSB, SCARB1, CCK

Publications for Cholelithiasis

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50PubMed
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Articles related to Cholelithiasis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Prevalence of cholelithiasis in Buenos Aires, Argentina. (23940909)
2013
2
Miniinvasive surgical management of cholelithiasis for elderly and senile patients: a retrospective study. (23863204)
2013
3
Double common bile duct with choledochal cyst and cholelithiasis: report of a case. (23553420)
2013
4
Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors. (22182015)
2012
5
History of cholelithiasis and cancer risk in a network of case-control studies. (22231026)
2012
6
Assessing disease severity in patients with cholelithiasis. (21442790)
2011
7
The learning curve of resident physicians using emergency ultrasonography for cholelithiasis and cholecystitis. (21175524)
2010
8
Combined features of low phospholipid-associated cholelithiasis and progressive familial intrahepatic cholestasis 3. (19840255)
2010
9
Laparoscopic cholecystectomy for cholelithiasis in a patient with myotonic dystrophy. (19660233)
2009
10
Microflora of bile aspirates in patients with acute cholecystitis with or without cholelithiasis: a tropical experience. (18839486)
2008
11
Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification. (17906958)
2008
12
Ectopic partial intrahepatic gall bladder with cholelithiasis--a rare anomaly. (18298024)
2007
13
Asymptomatic cholelithiasis in children with sickle cell disease: early or delayed cholecystectomy? (17197975)
2007
14
Cholelithiasis and cholecystitis in a retained gallbladder remnant after cholecystectomy. (18035268)
2007
15
Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis. (16505288)
2006
16
Cholelithiasis and chronic cholangiohepatitis in a mute swan (Cygnus olor). (16461625)
2006
17
Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin. (17163271)
2006
18
Sludge ball, pseudolithiasis, cholelithiasis and choledocholithiasis from intrauterine life to 2 years: a 13-year follow-up. (15795598)
2005
19
Risk of cholelithiasis in sickle cell anemia. (15713573)
2005
20
Gastric electrical activity in patients with cholelithiasis undergoing laparoscopic cholecystectomy: a prospective controlled study. (15151621)
2004
21
Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. (15314689)
2004
22
Aspects of the humoral and cellular immune response in hepatitis associated with cholelithiasis. (16004226)
2004
23
Combined needlescopic cholecystectomy and laparoscopic splenectomy for the treatment of thalassaemic splenomegaly and cholelithiasis. (14750388)
2003
24
Prevalence of cholelithiasis in hemodialysis patients. (12834185)
2003
25
Endoscopic sphincterotomy prior to laparoscopic cholecystectomy for the treatment of cholelithiasis. (12632131)
2003
26
The influence of local active warming on pain relief of patients with cholelithiasis during rescue transport. (12707148)
2003
27
Cirrhosis and cholelithiasis. (11713945)
2001
28
Management of symptomatic cholelithiasis in pregnancy. (17264587)
2001
29
Dynamic and ultrastructural study of sphincter of Oddi in early-stage cholelithiasis in rabbits with hypercholesterolemia. (11819533)
2000
30
Clinical presentations and predisposing factors of cholelithiasis and sludge in children. (11045839)
2000
31
An ultrasonographic evaluation of gallbladder emptying in patients with cholelithiasis. (11129272)
2000
32
Phenotypic characterization of lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology Of biliary lipid secretion. (10553010)
1999
33
Similarity in gallstone formation from 900 kcal/day diets containing 16 g vs 30 g of daily fat: evidence that fat restriction is not the main culprit of cholelithiasis during rapid weight reduction. (9539651)
1998
34
Cholelithiasis and dietary risk factors: an epidemiologic investigation in Vidauban, Southeast France. General Practitioner's Group of Vidauban. (9753282)
1998
35
Asymptomatic cholelithiasis revisited. (9828719)
1998
36
Cholelithiasis in early infancy. (9156860)
1997
37
Cholelithiasis, cholecystitis, and common bile duct stones. (9229169)
1997
38
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. (9254065)
1997
39
Biliary ascariasis and cholelithiasis. (9476782)
1997
40
Re: "Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.)". (7653477)
1995
41
Cholelithiasis in pediatric cardiac transplant patients on cyclosporine. (7722832)
1995
42
Hyperplastic innervation of vasoactive intestinal peptide in human gallbladder with cholelithiasis. (7579816)
1995
43
Definitive surgical treatment for cholelithiasis in selected patients with liver cirrhosis. (8857453)
1995
44
Cholelithiasis in infants with Down syndrome: report of two cases. (7670266)
1995
45
Postprandial gallbladder motor function: refilling and turnover of bile in health and in cholelithiasis. (7615209)
1995
46
Effects of cholelithiasis and cholecystectomy on gastric emptying. (7932336)
1994
47
Cholelithiasis associated with medroxyprogesterone acetate therapy in men. (1385654)
1992
48
Cholelithiasis associated with a variant of annular pancreas. (1800357)
1991
49
Cholelithiasis in a 2-year-old child with reflux esophagitis and hiatus hernia. (7365594)
1980
50
Cholelithiasis in the newborn infant in association with congenital toxoplasmosis and hereditary elliptocytosis. (5946658)
1966

Genetic Variations for Cholelithiasis

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Expression for genes affiliated with Cholelithiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for genes affiliated with Cholelithiasis

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37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4UGT1A10, UGT1A4
210.4UGT1A3, UGT1A10
3
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10.3UGT1A3, UGT1A10, UGT1A1
410.3UGT1A4, UGT1A10, UGT1A3
5
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10.3UGT1A4, UGT1A1, UGT1A3, SULT1E1
6
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10.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
7
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10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
8
Acetaminophen metabolism
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10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
9
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10.2UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
10
Hide members
10.1GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
11
Hide members
10.1SCARB1, GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10
12
Hide members
10.1SULT1E1, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7

Compounds for genes affiliated with Cholelithiasis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cholelithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1sn38 glucuronide4410.7GUSB, UGT1A7, UGT1A1
2lamotrigine44 1111.7UGT1A1, UGT1A3, UGT1A4, GUSB
3n-hydroxy phip4410.7UGT1A4, UGT1A1, UGT1A10, UGT1A7
4ezetimibe44 1111.7UGT1A3, UGT1A1, SCARB1, GPT
5loxiglumide4410.7SST, CCKAR, CCK
6p-nitrophenol44 1111.7UGT1A4, UGT1A1, UGT1A3, SULT1E1
7Ezogabine 1110.6UGT1A4, UGT1A3, UGT1A1
8propofol44 49 1112.6UGT1A3, UGT1A4, UGT1A10, UGT1A1
9uridine diphosphate4410.6UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4
10lactulose4410.6GPT, GUSB, CCK
11glucuronide4410.6UGT1A3, GUSB, UGT1A1, UGT1A10, UGT1A7, UGT1A4
12udp glucuronic acid4410.6GUSB, UGT1A1, UGT1A10
13cotinine44 2411.6UGT1A4, UGT1A1, GUSB, UGT1A10, UGT1A7, UGT1A3
14ursodeoxycholic acid44 11 2412.6GGT1, ABCB4, GPT, CCK
15imipramine44 49 28 11 2414.6UGT1A7, UGT1A4, UGT1A1, UGT1A3, UGT1A10
16glycocholate4410.6GUSB, GPT, ABCB4
17etiocholanolone44 2411.6UGT1A4, UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1
18silymarin4410.6UGT1A1, GUSB, GPT, GGT1
19estriol28 11 2412.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
20androsterone glucuronide44 2411.6UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1
213-alpha-androstanediol glucuronide44 2411.6GUSB, UGT1A3, UGT1A4, UGT1A1, UGT1A5, UGT1A10
222-methoxyestradiol44 59 2412.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A4, UGT1A1
23morphine44 49 28 1113.6UGT1A3, CCK, CCKAR, GUSB, UGT1A4, UGT1A1
24(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)2410.6GUSB, UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1
25aldosterone 18-glucuronide44 2411.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
26bilirubin diglucuronide44 2411.6UGT1A4, GUSB, UGT1A1, UGT1A5, UGT1A3, UGT1A7
27mycophenolate mofetil44 49 1112.6GGT1, UGT1A10, UGT1A1, GPT
28troglitazone44 28 59 1113.6UGT1A4, GPT, UGT1A3, UGT1A1, UGT1A10
29codeine44 49 28 11 2414.6UGT1A7, UGT1A4, UGT1A5, UGT1A1, UGT1A10, UGT1A3
30estrogen4410.6ABCB4, UGT1A4, UGT1A10
31ethyl glucuronide44 2411.6UGT1A3, GGT1, GUSB, UGT1A4, UGT1A1, UGT1A10
32estrone44 28 11 2413.5SULT1E1, UGT1A5, UGT1A3, UGT1A7, UGT1A10, UGT1A1
33valproic acid44 49 11 2413.5UGT1A7, UGT1A10, GGT1, GPT, UGT1A3, UGT1A4
34nicotine44 49 28 1113.5UGT1A3, GPT, GGT1, UGT1A10, UGT1A4, UGT1A1
35cyproheptadine28 44 1112.5UGT1A3, SST, CCK
36quercetin44 59 11 2413.5UGT1A3, UGT1A1, GUSB, SULT1E1, GGT1
37acetaminophen44 2 49 11 2414.5SULT1E1, GPT, UGT1A7, UGT1A10, UGT1A1, UGT1A4
38tamoxifen44 49 28 1113.5UGT1A4, UGT1A1, SULT1E1, GGT1, UGT1A3, SERPINB5
39flunitrazepam44 28 1112.5UGT1A3, UGT1A1, GUSB
40estradiol44 11 2412.5UGT1A5, UGT1A7, SCARB1, SULT1E1, UGT1A3, UGT1A4
41cholesterol44 28 11 2413.5LPXN, ABCB4, UGT1A1, GGT1, SCARB1, CCK
42glucose4410.4CCK, SCARB1, PSG2, LPXN, CCKAR
43dopamine44 28 11 2413.4GGT1, CCK, CCKAR
44phenobarbital44 28 1112.4GGT1, GUSB, UGT1A1, GPT
45intralipid4410.3CCK, CCKAR, SST
46retinoic acid44 2411.3SST, CCK, UGT1A10, UGT1A1, UGT1A4, UGT1A5
47testosterone44 59 11 2413.3SST, SULT1E1, GGT1, UGT1A7, UGT1A10, SERPINB5
48amine4410.2UGT1A3, UGT1A7, UGT1A1, UGT1A4
49buprenorphine44 28 1112.1GUSB, UGT1A3, UGT1A1
50lipid4410.1GGT1, CCKAR, SERPINB5, PSG2, GPT, LPXN

GO Terms for genes affiliated with Cholelithiasis

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16Gene Ontology
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Cellular components related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00578910.2UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4

Biological processes related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1flavone metabolic processGO:05155210.6UGT1A7, UGT1A1, UGT1A10
2xenobiotic glucuronidationGO:05269710.6UGT1A1, UGT1A7, UGT1A3
3flavonoid glucuronidationGO:05269610.5UGT1A1, UGT1A7, UGT1A3
4cellular glucuronidationGO:05269510.5UGT1A10, UGT1A1, UGT1A4
5retinoic acid metabolic processGO:04257310.4UGT1A1, UGT1A7, UGT1A3
6xenobiotic metabolic processGO:00680510.4UGT1A4, UGT1A1, UGT1A5, GGT1, SULT1E1
7metabolic processGO:00815210.4UGT1A3, UGT1A10, UGT1A5
8estrogen metabolic processGO:00821010.4SULT1E1, UGT1A1
9digestionGO:00758610.2CCKAR, UGT1A1, SST
10small molecule metabolic processGO:04428110.1SCARB1, GUSB, UGT1A4, UGT1A1, GPT, ABCB4
11response to nutrientGO:00758410.0SST, UGT1A1, CCKAR

Molecular functions related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:01502010.3UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
2retinoic acid bindingGO:00197210.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
3protein heterodimerization activityGO:04698210.2UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4
4enzyme bindingGO:01989910.1UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
5protein homodimerization activityGO:0428039.9SCARB1, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3

Products for genes affiliated with Cholelithiasis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Cholelithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet