MCID: CHL004
MIFTS: 50

Cholelithiasis malady

Summaries for Cholelithiasis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A gallstone is a crystalline concretion formed within the gallbladder by accretion of bile components.... more...

MalaCards: Cholelithiasis is related to choledocholithiasis and thalassemia. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are nicotine degradation III and thyroid hormone metabolism II (via conjugation and/or degradation). The drug ursodiol and the compounds sn38 glucuronide and lamotrigine have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and spinal cord, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Cholelithiasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

cholelithiasis 8 10 45 61


External Ids:

Disease Ontology8 DOID:10211
ICD9CM27 574.5
MeSH35 D002769

Related Diseases for Cholelithiasis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1choledocholithiasis30.7GUSB, GPT, GGT1
2thalassemia30.3UGT1A1
3acute pancreatitis30.3CCKAR, CCK, PSG2, SST, GPT
4gilbert syndrome30.2UGT1A4, UGT1A1, UGT1A7
5adenoma30.1PSG2, SCARB1, SST, CDX2, GGT1, SERPINB5
6adenocarcinoma30.0CCKAR, CCK, PSG2, GUSB, UGT1A1, UGT1A7
7atherosclerosis29.8SCARB1, LPXN, GGT1
8obstructive jaundice29.8CCK, PSG2, GPT, GGT1
9hypercholesterolemia29.8GGT1, GPT, LPXN
10bile reflux29.8CCK
11insulin resistance29.8GGT1, GPT, SST, SCARB1
12hepatitis c29.8GGT1, ABCB4, GPT
13colorectal cancer29.8PSG2, GUSB, CDX2, SERPINB5
14sickle cell disease10.3
15gallbladder disease 110.3
16sickle cell anemia10.2
17hereditary spherocytosis10.2
18ascariasis10.1
19appendicitis10.1
20situs inversus10.1
21choledochal cyst10.1
22ileus10.1
23megaesophagus10.0
24hemoglobin d disease10.0
25hemoglobin c disease10.0
26intrahepatic cholestasis10.0
27primary hyperparathyroidism10.0
28beta thalassemia10.0
29portal vein thrombosis10.0
30abdominal aortic aneurysm10.0
31biliary dyskinesia10.0
32down syndrome10.0
33ascending cholangitis10.0
34aortic aneurysm10.0
35bladder carcinoma10.0
36annular pancreas10.0
37left-sided gallbladder10.0
38autonomic dysfunction10.0
39somatostatin analog10.0
40cystic fibrosis10.0GUSB
41esophagitis10.0CDX2
42cholecystitis10.0GPT, CCK
43constipation10.0CCK
44familial adenomatous polyposis10.0CDX2
45diarrhea10.0UGT1A1, SST
46anorexia nervosa10.0CCK
47gallbladder cancer10.0CDX2, PSG2
48protein-energy malnutrition10.0CCK
49pituitary adenoma10.0SST
50coronary heart disease10.0GGT1, SCARB1

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Clinical Features for Cholelithiasis

Drugs & Therapeutics for Cholelithiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cholelithiasis

Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

Search NIH Clinical Center for Cholelithiasis

Search CenterWatch for Cholelithiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cholelithiasis

Anatomical Context for Cholelithiasis

Sources:
33MalaCards
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MalaCards organs/tissues related to Cholelithiasis:

33
Ovary, Liver, Spinal cord, Kidney, Bone marrow, Heart, Smooth muscle, Small intestine, Colon, Pancreas, Breast, Prostate, B cells, Fetal liver, Pancreatic islet

Animal Models for Cholelithiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cholelithiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1SULT1E1, ABCB4, CDX2, GUSB, SCARB1, CCK

Publications for Cholelithiasis

Sources:
51PubMed
See all sources

Articles related to Cholelithiasis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Chinese medicinal herbs for cholelithiasis. (23813425)
2013
2
Prevalence, pattern, sensitivity and resistance to antibiotics of different bacteria isolated from port site infection in low risk patients after elective laparoscopic cholecystectomy for symptomatic cholelithiasis at tertiary care hospital of Kashmir. (22414004)
2013
3
Analysis of serum lipid profile in cholelithiasis patients. (23787527)
2013
4
Low phospholipid-associated cholestasis and cholelithiasis. (23141892)
2012
5
Assessment of characteristics of patients with cholelithiasis from economically deprived rural Karachi, Pakistan. (22741543)
2012
6
Congenital duplex gallbladder and biliary mucocele associated with partial hepatic cholestasis and cholelithiasis in a cat. (22942442)
2012
7
Autonomic dysfunction and risk of cholelithiasis in cirrhosis. (21188346)
2010
8
Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat. (18684151)
2008
9
Cefepime for prophylaxis of infections in the surgery of cholelithiasis. Results of a multicentric comparative trial. (18551818)
2008
10
Peroral cholecystoscopy with electrohydraulic lithotripsy for treatment of symptomatic cholelithiasis in end-stage liver disease (with videos). (18155435)
2008
11
Frequency of infection in cholelithiasis. (17204221)
2007
12
Cholelithiasis in four callitrichid species (Leontopithecus, Callithrix). (17312811)
2006
13
Combined endoscopic treatment for cholelithiasis associated with choledocholithiasis. (15868278)
2005
14
Analysis of 645 patients with primary hyperparathyroidism with special references to cholelithiasis. (16258203)
2005
15
Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. (15775677)
2005
16
Body weight gain as the major risk factor of cholelithiasis in women and an important risk factor in man. (16119627)
2005
17
Cholelithiasis and cholecystitis: changing prevalence in an African community. (16334500)
2005
18
Non-complicated cholelithiasis associated with GERD. Results of combined laparoscopic surgery in low risk patients. (15117236)
2004
19
Laparoscopic cholecystecomy in a 16-day-old infant with chronic cholelithiasis. (14694400)
2004
20
Polymorphism in transmembrane region of MICA gene and cholelithiasis. (12854159)
2003
21
ABCB4 gene mutation-associated cholelithiasis in adults. (12891548)
2003
22
Treatment of cholelithiasis in children with sickle cell disease. (12817741)
2003
23
Association of the presence of Helicobacter in gallbladder tissue with cholelithiasis and cholecystitis. (14662950)
2003
24
Congenital web of the common bile duct in association with cholelithiasis. (12140619)
2002
25
Cholelithiasis in an infant with Klinefelter's syndrome. (12356111)
2002
26
Study of serum calcium and trace elements in chronic cholelithiasis. (12190737)
2002
27
Tract microflora in Saudi patients with cholelithiasis. (11469952)
2001
28
Incidence of cholelithiasis in 125 continent urinary diversions. (11371876)
2001
29
EUS for detection of occult cholelithiasis in patients with idiopathic pancreatitis. (10625791)
2000
30
Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis. (11108738)
2000
31
Prevalence of cholelithiasis: results of an epidemiologic investigation in Vidauban, southeast France. General Practitioner's Group of Vidauban. (10489913)
1999
32
Recanalization of a portal-vein thrombosis and partial resolution of biliary cirrhosis following cholecystectomy for cholelithiasis in an infant. (10415297)
1999
33
Prevalence of cholelithiasis in non-diabetic haemodialysis and continuous ambulatory peritoneal dialysis patients. (9453403)
1998
34
Rim sign. Radionuclide imaging in a patient with acute gangrenous cholecystitis and cholelithiasis after nonspecific abdominal ultrasonography. (9193810)
1997
35
Cholelithiasis and pancreatic cancer. A case-control study. (9451671)
1997
36
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
37
Risk of pancreatic cancer associated with cholelithiasis, cholecystectomy, or gastrectomy. (8654135)
1996
38
Cholelithiasis in paediatric renal transplant patients: implications for screening and management. (8813941)
1996
39
Cholelithiasis, cholecystitis, and pancreatitis. (8921766)
1996
40
Comparison of mutagenic activity of bile between Chilean and Japanese female patients having cholelithiasis. (8950352)
1996
41
ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. (7795450)
1995
42
Hormonal control of cholesterol cholelithiasis in the female hamster. (7595072)
1995
43
Prevalence of cholelithiasis according to alcoholic liver disease: a possible role of apolipoproteins AI and AII. (7771667)
1995
44
Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. (7555451)
1995
45
Surgery in the elderly: observations on the pathophysiology and treatment of cholelithiasis. (8224042)
1993
46
The bacteriology of cholelithiasis--China versus Japan. (1787607)
1991
47
Cholelithiasis in patients with variegate porphyria. (2007776)
1991
48
Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla]. (2278184)
1990
49
Hemoglobin SD disease associated with cholecystitis and cholelithiasis in pregnancy. (7121920)
1982
50
INCIDENCE OF DISEASE IN THE NAVAJO INDIAN. A NECROPSY STUDY OF CORONARY AND AORTIC ATHEROSCLEROSIS, CHOLELITHIASIS, AND NEOPLASTIC DISEASE. (14120694)
1964

Genetic Variations for Cholelithiasis

Expression for genes affiliated with Cholelithiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for genes affiliated with Cholelithiasis

Sources:
38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4UGT1A10, UGT1A4
210.4UGT1A3, UGT1A10
3
Hide members
10.3UGT1A3, UGT1A10, UGT1A1
410.3UGT1A4, UGT1A10, UGT1A3
5
Hide members
10.3UGT1A4, UGT1A1, UGT1A3, SULT1E1
6
Hide members
10.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
7
Hide members
10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
8
Acetaminophen metabolism
Hide members
10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
9
Hide members
10.2UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
10
Hide members
10.1GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
11
Hide members
10.1SCARB1, GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10
12
Hide members
10.1SULT1E1, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7

Compounds for genes affiliated with Cholelithiasis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Cholelithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1sn38 glucuronide4510.7UGT1A7, UGT1A1, GUSB
2lamotrigine45 1111.7UGT1A3, UGT1A1, UGT1A4, GUSB
3n-hydroxy phip4510.7UGT1A4, UGT1A1, UGT1A10, UGT1A7
4ezetimibe45 1111.7SCARB1, UGT1A1, UGT1A3, GPT
5loxiglumide4510.7SST, CCK, CCKAR
6p-nitrophenol45 1111.7UGT1A4, UGT1A1, UGT1A3, SULT1E1
7Ezogabine 1110.6UGT1A3, UGT1A1, UGT1A4
8propofol45 50 1112.6UGT1A3, UGT1A10, UGT1A1, UGT1A4
9uridine diphosphate4510.6UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
10lactulose4510.6GPT, GUSB, CCK
11glucuronide4510.6GUSB, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
12udp glucuronic acid4510.6GUSB, UGT1A1, UGT1A10
13cotinine45 2411.6GUSB, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
14ursodeoxycholic acid45 11 2412.6CCK, GPT, ABCB4, GGT1
15imipramine45 50 29 11 2414.6UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
16glycocholate4510.6GUSB, GPT, ABCB4
17etiocholanolone45 2411.6UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
18silymarin4510.6GGT1, GPT, UGT1A1, GUSB
19estriol29 11 2412.6UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
20(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)2410.6GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
21bilirubin diglucuronide45 2411.6UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1, GUSB
222-methoxyestradiol45 60 2412.6UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
23aldosterone 18-glucuronide45 2411.6GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
24morphine45 50 29 1113.6CCKAR, CCK, GUSB, UGT1A4, UGT1A1, UGT1A3
25androsterone glucuronide45 2411.6UGT1A7, UGT1A3, UGT1A10, UGT1A5, GUSB, UGT1A4
263-alpha-androstanediol glucuronide45 2411.6GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
27mycophenolate mofetil45 50 1112.6UGT1A1, UGT1A10, GPT, GGT1
28troglitazone45 29 60 1113.6UGT1A4, UGT1A1, UGT1A10, UGT1A3, GPT
29codeine45 50 29 11 2414.6GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
30estrogen4510.6UGT1A4, UGT1A10, ABCB4
31ethyl glucuronide45 2411.6GUSB, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
32estrone45 29 11 2413.5UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
33valproic acid45 50 11 2413.5UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3, GPT
34nicotine45 50 29 1113.5UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3, GPT
35cyproheptadine29 45 1112.5SST, UGT1A3, CCK
36quercetin45 60 11 2413.5GUSB, UGT1A1, UGT1A3, GGT1, SULT1E1
37acetaminophen45 2 50 11 2414.5CCK, UGT1A4, UGT1A1, UGT1A10, UGT1A7, GPT
38tamoxifen45 50 29 1113.5UGT1A4, UGT1A1, UGT1A3, GGT1, SULT1E1, SERPINB5
39flunitrazepam45 29 1112.5UGT1A3, UGT1A1, GUSB
40estradiol45 11 2412.5SCARB1, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
41cholesterol45 29 11 2413.5CCKAR, CCK, SCARB1, UGT1A1, LPXN, GPT
42glucose4510.4CCKAR, CCK, PSG2, SCARB1, LPXN
43dopamine45 29 11 2413.4CCKAR, CCK, GGT1
44phenobarbital45 29 1112.4GGT1, GPT, UGT1A1, GUSB
45intralipid4510.3CCKAR, CCK, SST
46retinoic acid45 2411.3CCK, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
47testosterone45 60 11 2413.3UGT1A5, UGT1A1, UGT1A4, SCARB1, CCK, UGT1A10
48amine4510.2UGT1A3, UGT1A7, UGT1A1, UGT1A4
49buprenorphine45 29 1112.1GUSB, UGT1A1, UGT1A3
50lipid4510.1PSG2, SCARB1, LPXN, GPT, ABCB4, GGT1

GO Terms for genes affiliated with Cholelithiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00578910.2UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4

Biological processes related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1flavone metabolic processGO:05155210.6UGT1A7, UGT1A1, UGT1A10
2xenobiotic glucuronidationGO:05269710.6UGT1A1, UGT1A7, UGT1A3
3flavonoid glucuronidationGO:05269610.5UGT1A1, UGT1A7, UGT1A3
4cellular glucuronidationGO:05269510.5UGT1A10, UGT1A1, UGT1A4
5retinoic acid metabolic processGO:04257310.4UGT1A1, UGT1A7, UGT1A3
6xenobiotic metabolic processGO:00680510.4UGT1A4, UGT1A1, UGT1A5, GGT1, SULT1E1
7metabolic processGO:00815210.4UGT1A3, UGT1A10, UGT1A5
8estrogen metabolic processGO:00821010.4SULT1E1, UGT1A1
9digestionGO:00758610.2CCKAR, UGT1A1, SST
10small molecule metabolic processGO:04428110.1SCARB1, GUSB, UGT1A4, UGT1A1, GPT, ABCB4
11response to nutrientGO:00758410.0SST, UGT1A1, CCKAR

Molecular functions related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:01502010.3UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
2retinoic acid bindingGO:00197210.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
3protein heterodimerization activityGO:04698210.2UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4
4enzyme bindingGO:01989910.1UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
5protein homodimerization activityGO:0428039.9SCARB1, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3

Products for genes affiliated with Cholelithiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholelithiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet