MCID: CHL004
MIFTS: 48

Cholelithiasis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

Aliases & Descriptions for Cholelithiasis:

Name: Cholelithiasis 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 35 574.5
SNOMED-CT 64 197397004 266475002
ICD10 33 K80
UMLS 69 C0006739

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to gallbladder disease 1 and dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Dopamine and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and skin, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 71 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
id Related Disease Score Top Affiliating Genes
1 gallbladder disease 1 11.8
2 dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema 10.9
3 cholecystitis 10.8
4 erythrocytosis due to bisphosphoglycerate mutase deficiency 10.7
5 spherocytosis, type 1 10.7
6 thalassemia-beta, dominant inclusion-body 10.7
7 cholecystolithiasis 10.7
8 clonorchiasis 10.7
9 stomatocytosis i 10.7
10 dehydrated hereditary stomatocytosis 2 10.7
11 gallbladder disease 4 10.7
12 amyotrophic lateral sclerosis 3 10.3 ABCB4 NR1H4
13 cholestasis, benign recurrent intrahepatic, 2 10.3 ABCB4 NR1H4
14 familial progressive cardiac conduction defect 10.3 ALB APOE
15 central nervous system germinoma 10.3 APOE SST
16 trichodysplasia-xeroderma 10.2 ALB SST
17 anhidrosis 10.2 ABCB4 CCK
18 hyperbilirubinemia, familial transient neonatal 10.2 UGT1A1 UGT1A6
19 polycythemia due to hypoxia 10.2 CCK GUSB
20 myocardial stunning 10.2 CCK SST
21 cholestasis, intrahepatic, of pregnancy, 1 10.2 ABCB4 NR1H4
22 punctate epithelial keratoconjunctivitis 10.2 UGT1A1 UGT1A6
23 pseudoarthrosis 10.2 ABCB4 ALB NR1H4
24 chronic rheumatic pericarditis 10.2 ABCB4 ALB NR1H4
25 choledocholithiasis 10.2
26 female infertility of uterine origin 10.2 ALB GPT
27 bile duct cystadenocarcinoma 10.2 ALB GPT
28 bacterial meningitis 10.1 ABCB4 ALB GPT
29 renal artery disease 10.1 ALB UGT1A1 UGT1A6
30 dyserythropoietic anemia, congenital, type ii 10.1 ABCB4 APOE SCARB1
31 patent foramen ovale 10.1 ALB GPT NR1H4
32 coronary artery dissection, spontaneous 10.1 ALB SST
33 fiedler's myocarditis 10.1 ALB GPT SST
34 tmem237-related joubert syndrome 10.1 HBB UGT1A1
35 iron metabolism disease 10.1 ABCG8 APOE
36 typhoid fever 10.1 ALB CCK SST UGT1A1
37 pancreatitis 10.1
38 fetal hemoglobin quantitative trait locus 1 10.0 HBB UGT1A1 UGT1A6
39 mandibular cancer 10.0 CCK CCKAR SST
40 lacrimal system cancer 10.0 CCK CCKAR SST
41 pyelitis 10.0 ALB GPT UGT1A1 UGT1A6
42 tricuspid valve stenosis 10.0 CCK SST
43 fallopian tube leiomyosarcoma 10.0 ALB CCK GPT GUSB
44 eclampsia 10.0 ABCB4 CYP7A1 GPT NR1H4
45 sickle cell disease 10.0
46 kohler's disease 9.9 ABCB4 ALB GPT GUSB UGT1A1
47 acute contagious conjunctivitis 9.9 CCK CCKAR
48 hepatitis 9.9
49 cholestasis 9.9
50 obesity 9.9

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 APOE CCKAR CYP7A1 NR1H4 SST ABCB4
2 endocrine/exocrine gland MP:0005379 9.76 ABCB4 ALB APOE CCK CCKAR GUSB
3 homeostasis/metabolism MP:0005376 9.7 ABCB4 ABCG8 ALB APOE CCK CCKAR
4 liver/biliary system MP:0005370 9.23 ABCB4 ABCG8 ALB APOE CCKAR CYP7A1

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Clonidine Approved Phase 4 4205-90-7 2803
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
10
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
11
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
12
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
15
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
16
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
17
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2 128-13-2 31401
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
20
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
21
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
22
Ephedrine Approved Phase 4 299-42-3 9294
23
Ondansetron Approved Phase 4 99614-02-5 4595
24
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Etomidate Approved Phase 4 33125-97-2 36339 667484
27
Pseudoephedrine Approved Phase 4 90-82-4 7028
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
29
Meperidine Approved Phase 4 57-42-1 4058
30
Levobupivacaine Approved Phase 4 27262-47-1 92253
31
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
32
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
33
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
34
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
35
Sulbactam Approved Phase 4 68373-14-8
36 tannic acid Approved, Nutraceutical Phase 4
37 Analgesics Phase 4
38 calcium channel blockers Phase 4
39 Flurbiprofen axetil Phase 4
40 Adjuvants, Anesthesia Phase 4
41 Narcotics Phase 4
42 Nefopam Phase 4
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Sodium Channel Blockers Phase 4
45 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
46 Analgesics, Non-Narcotic Phase 4
47 Analgesics, Opioid Phase 4
48 Tranquilizing Agents Phase 4
49 Anesthetics Phase 4,Phase 1,Phase 2
50 Anesthetics, Dissociative Phase 4

Interventional clinical trials:

(show top 50) (show all 242)
id Name Status NCT ID Phase
1 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
2 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
3 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
4 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4
6 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
7 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
8 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4
9 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
10 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4
11 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4
12 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
13 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
14 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4
15 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
16 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
17 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4
18 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
19 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4
20 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
21 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4
22 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4
23 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4
24 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Recruiting NCT02472509 Phase 4
25 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
26 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4
27 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Recruiting NCT03180229 Phase 4
28 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
29 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Recruiting NCT02057679 Phase 4
30 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Not yet recruiting NCT03168555 Phase 4
31 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4
32 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4
33 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4
34 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
35 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
36 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
37 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
38 Indications for Gallbladder Surgery in Gallstone Disease Completed NCT01190280 Phase 3
39 Epidemiology of Gallbladder Sludge and Stones in Pregnancy Completed NCT00131131 Phase 3
40 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
41 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
42 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
43 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
44 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
45 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3
46 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
47 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3
48 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Recruiting NCT02490111 Phase 3
49 Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy Recruiting NCT02595086 Phase 3
50 Pentoxifylline Treatment in Acute Pancreatitis (AP) Enrolling by invitation NCT02487225 Phase 3

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

id Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

39
Liver, Pancreas, Skin, Heart, Kidney, Colon, Smooth Muscle

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 638)
id Title Authors Year
1
Effect of emodin on mobility signal transduction system of gallbladder smooth muscle in Guinea pig with cholelithiasis. ( 27794381 )
2016
2
The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study. ( 27464291 )
2016
3
Endoscopic management of choledocholithiasis and cholelithiasis in patients with cirrhosis. ( 26799755 )
2016
4
Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. ( 27891394 )
2016
5
Frequency of Cholelithiasis and Biliary Pathology in the Easter Island Rapanui and Non-Rapanui Populations. ( 27039794 )
2016
6
Spontaneous Cholelithiasis in a Squirrel Monkey (Saimiri sciureus). ( 26884412 )
2016
7
Cholelithiasis in Patients with Gaucher Disease type 1: Risk Factors and the Role of ABCG5/ABCG8 Gene Variants. ( 27981300 )
2016
8
Choledocholithiasis Without Cholelithiasis: Should the Gallbladder Stay or Should It Go? ( 26738738 )
2016
9
Focal gall bladder polyarteritis nodosa in a case of cholelithiasis. ( 27728677 )
2016
10
The Progression of Cholelithiasis to Gallstone Ileus: Do Large Gallstones Warrant Surgery? ( 26857589 )
2016
11
Response to: Serum paraoxonase and malondialdehyde levels in asymptomatic cholelithiasis. ( 26831617 )
2016
12
To leave no stone unturned: cholelithiasis and subsequent gallstone ileus. ( 27154989 )
2016
13
HOSPITALIZATIONS FOR CHOLECYSTITIS AND CHOLELITHIASIS IN THE STATE OF RIO GRANDE DO SUL, BRAZIL. ( 27438030 )
2016
14
UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children. ( 27981643 )
2016
15
Risk Factors for Cholelithiasis. ( 27467059 )
2016
16
Prevalence of Cholelithiasis and Choledocholithiasis in Morbidly Obese South Indian Patients and the Further Development of Biliary Calculus Disease After Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass. ( 26910024 )
2016
17
Pregnane receptor gene polymorphisms, pathogenic bacteria distribution and drug sensitivity, and TCM syndrome differentiation in patients with cholelithiasis. ( 27086146 )
2016
18
The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study. ( 27063855 )
2016
19
Prevalence and characteristics of clinically significant retained common bile duct stones after laparoscopic cholecystectomy for symptomatic cholelithiasis. ( 27847796 )
2016
20
Risk factors, complications and outcome of cholelithiasis in children: A retrospective, single-centre review. ( 27236017 )
2016
21
Possible Atazanavir-Induced Cholelithiasis in a Pregnant Woman: A Case Report. ( 27621492 )
2016
22
Cholelithiasis in children with CHD: is it a problem? ( 27322515 )
2016
23
COMMENT: HOSPITALIZATIONS FOR CHOLECYSTITIS AND CHOLELITHIASIS IN THE STATE OF RIO GRANDE DO SUL, BRAZILREPLY. ( 28076493 )
2016
24
Elective cholecystectomy reduces morbidity of cholelithiasis in pediatric sickle cell disease. ( 27643455 )
2016
25
Corrigendum to "The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study" [Int. J. Surg. 30 (2016) 13-18]. ( 27693476 )
2016
26
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
27
Evidence-based clinical practice guidelines for cholelithiasis 2016. ( 27942871 )
2016
28
Trends in Follow-Up of Patients Presenting to the Emergency Department with Symptomatic Cholelithiasis. ( 26837281 )
2016
29
Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient. ( 27746433 )
2016
30
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. ( 27033116 )
2016
31
Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid. ( 28089591 )
2016
32
Cholelithiasis and complicated chronic pancreatitis mimicking malignancy. ( 26882896 )
2016
33
Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder. ( 27376020 )
2016
34
Severe acute hemorrhagic pancreatitis secondary to cholelithiasis as a rare cause of sudden unexpected death in medico-legal case: A case report. ( 27559973 )
2016
35
Acute pain management in symptomatic cholelithiasis. ( 27830044 )
2016
36
Case report of cholelithiasis in a patient with type 1 Gaucher disease. ( 27915213 )
2016
37
Neonatal Bartter syndrome with cholelithiasis and hydrocephalus: Rare association. ( 27682612 )
2016
38
Comment on "The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia". ( 26813445 )
2016
39
Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population. ( 27995261 )
2016
40
COMPARATIVE ANALYSIS OF PREOPERATIVE ULTRASONOGRAPHY REPORTS WITH INTRAOPERATIVE SURGICAL FINDINGS IN CHOLELITHIASIS. ( 27120735 )
2016
41
Prevalence of cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. ( 25834555 )
2015
42
Endoscopic Gallbladder Drainage in Medically Inoperable Patients with Symptomatic Cholelithiasis: A Tube to Avoid "Going Down the Tubes"? ( 26022704 )
2015
43
Long-term risk of pancreatitis and diabetes after cholecystectomy in patients with cholelithiasis but no pancreatitis history: A 13-year follow-up study. ( 26143191 )
2015
44
The Risk of Depression in Patients With Cholelithiasis Before and After Cholecystectomy: A Population-based Cohort Study. ( 25761193 )
2015
45
Single-incision cholecystectomy in a patient with situs inversus totalis presenting with cholelithiasis: A case report. ( 26303735 )
2015
46
The correlation of Helicobacter Pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia. ( 26531273 )
2015
47
Hospital readmission after emergency room visit for cholelithiasis. ( 25959838 )
2015
48
Liraglutide-related cholelithiasis. ( 25725635 )
2015
49
The deletion of the estrogen receptor I+ gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice. ( 26232687 )
2015
50
Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint's triad. ( 26366362 )
2015

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ABCB4 ABCG8 ALB APOE CYP7A1 GPT
2
Show member pathways
12.33 ABCG8 ALB APOE SCARB1
3 12.22 APOE HBB UGT1A1 UGT1A6
4
Show member pathways
12.04 ALB APOE HBB SCARB1
5
Show member pathways
11.64 ALB APOE HBB SCARB1
6
Show member pathways
11.42 CYP7A1 UGT1A1 UGT1A6
7 11.09 ABCB4 CYP7A1 NR1H4
8
Show member pathways
11.09 ABCG8 APOE CYP7A1 SCARB1
9 10.87 ABCB4 ABCG8 CYP7A1 NR1H4 SCARB1
10 10.71 CYP7A1 NR1H4
11 10.61 ABCB4 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 ABCB4 ALB APOE GPT GUSB HBB
2 intracellular membrane-bounded organelle GO:0043231 9.55 CYP7A1 GUSB SCARB1 UGT1A1 UGT1A6
3 extracellular space GO:0005615 9.17 ALB APOE CCK GPT GUSB HBB
4 endocytic vesicle lumen GO:0071682 8.96 APOE HBB

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 ABCB4 ABCG8 SST UGT1A1
2 lipid transport GO:0006869 9.77 ABCB4 APOE SCARB1
3 receptor-mediated endocytosis GO:0006898 9.76 ALB APOE HBB SCARB1
4 steroid metabolic process GO:0008202 9.75 APOE CYP7A1 UGT1A1
5 cellular oxidant detoxification GO:0098869 9.67 ALB APOE HBB
6 digestion GO:0007586 9.65 CCKAR SST UGT1A1
7 bile acid and bile salt transport GO:0015721 9.61 ALB NR1H4
8 lipid homeostasis GO:0055088 9.61 ABCB4 APOE
9 lipoprotein metabolic process GO:0042157 9.61 ALB APOE SCARB1
10 positive regulation of nitric-oxide synthase activity GO:0051000 9.6 APOE SCARB1
11 reverse cholesterol transport GO:0043691 9.58 APOE SCARB1
12 intestinal absorption GO:0050892 9.56 ABCB4 SCARB1
13 response to nutrient GO:0007584 9.56 ABCG8 CCKAR SST UGT1A1
14 cellular glucuronidation GO:0052695 9.55 UGT1A1 UGT1A6
15 fatty acid homeostasis GO:0055089 9.54 APOE NR1H4
16 triglyceride homeostasis GO:0070328 9.54 APOE NR1H4 SCARB1
17 high-density lipoprotein particle clearance GO:0034384 9.52 APOE SCARB1
18 xenobiotic glucuronidation GO:0052697 9.51 UGT1A1 UGT1A6
19 cholesterol efflux GO:0033344 9.5 ABCG8 APOE SCARB1
20 regulation of bile acid biosynthetic process GO:0070857 9.4 CYP7A1 NR1H4
21 high-density lipoprotein particle remodeling GO:0034375 9.33 ALB APOE SCARB1
22 cholesterol homeostasis GO:0042632 9.26 ABCG8 APOE CYP7A1 SCARB1
23 cholesterol catabolic process GO:0006707 8.8 APOE CYP7A1 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.26 UGT1A1 UGT1A6
2 antioxidant activity GO:0016209 9.16 ALB APOE
3 retinoic acid binding GO:0001972 8.96 UGT1A1 UGT1A6
4 cholesterol transporter activity GO:0017127 8.62 ABCG8 APOE

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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