MCID: CHL004
MIFTS: 48

Cholelithiasis malady

Gastrointestinal diseases category
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Summaries for Cholelithiasis

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Wikipedia:65 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards based summary: Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Steroid hormone biosynthesis and Bile secretion. The drug ursodiol and the compounds Etiocholanolone glucuronide and Estrone glucuronide have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and colon.

Aliases & Classifications for Cholelithiasis

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Cholelithiasis, Aliases & Descriptions:

Name: Cholelithiasis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:10211
MeSH34 D002769
ICD9CM27 574.5

Related Diseases for Cholelithiasis

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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis31.2CCK, GPT
2choledocholithiasis31.0GUSB, GPT
3sickle cell disease30.8UGT1A1, GUSB
4pancreatitis30.8CCK, ABCB4, SST
5cholestasis30.5GPT, ABCB4, CCK
6hepatitis30.5GPT, GUSB
7pancreatic cancer30.4SST, PSG2, CCK
8cholangitis30.3GPT, ABCB4
9liver cirrhosis30.3ABCB4, SST, GPT
10obesity29.8SCARB1, CCK, GPT
11acute pancreatitis29.8CCK, SST, PSG2, GPT
12colorectal cancer29.8GUSB, CCK, PSG2, UGT1A1
13obstructive jaundice29.7CCK, GPT, PSG2
14adenocarcinoma29.7SST, CCK, UGT1A1, GUSB, PSG2
15insulin resistance29.4GPT, SCARB1, SST
16crigler-najjar syndrome10.5UGT1A1
17gallbladder disease 110.3
18neonatal jaundice10.3GUSB, UGT1A1
19liver disease10.3
20kernicterus10.3UGT1A1, UGT1A5
21thalassemia10.3
22pancreas disease10.3CCK, PSG2
23steatorrhea10.2CCK, SST
24gastrointestinal system disease10.2PSG2, CCK
25short bowel syndrome10.2SST, CCK
26glucagonoma10.2CCK, SST
27sickle cell anemia10.2
28hiatus hernia10.2
29duodenal ulcer10.2CCK, SST
30bilirubin metabolic disorder10.2UGT1A5, UGT1A1
31peptic ulcer disease10.2CCK, SST
32hereditary spherocytosis10.2
33paraganglioma10.1SST, PSG2
34acromegaly10.1CCK, SST
35down syndrome10.1
36ascariasis10.1
37situs inversus10.1
38choledochal cyst10.1
39beta thalassemia10.1
40appendicitis10.1
41myotonic dystrophy10.1
42ileus10.1
43factor vii deficiency10.1SST, PSG2, UGT1A1
44primary sclerosing cholangitis10.1GPT, ABCB4
45gastritis10.1SST, CCK
46thyroid medullary carcinoma10.1CCK, SST, PSG2
47autoimmune hepatitis10.1GPT, UGT1A1
48neuroendocrine tumor10.1SST, CCK, PSG2
4921-hydroxylase deficiency10.1GPT, GUSB
50diarrhea10.1UGT1A1, SST

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Symptoms for Cholelithiasis

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Drugs & Therapeutics for Cholelithiasis

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Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cholelithiasis

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Anatomical Context for Cholelithiasis

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MalaCards organs/tissues related to Cholelithiasis:

32
Liver, Heart, Colon, Kidney, Pancreas, Bone marrow, Bone, Spleen, Spinal cord, Smooth muscle, Small intestine, Breast, Ovary, Prostate, Testes, B cells

Animal Models for Cholelithiasis or affiliated genes

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Publications for Cholelithiasis

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Articles related to Cholelithiasis:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Adrenal myelolipoma, cholelithiasis and calcified spleen: retrospective diagnosis of sickle cell anemia using a novel triad of abdominal imaging findings. (25053687)
2014
2
Cumulative exposure to ritonavir-boosted atazanavir is associated with cholelithiasis in patients with HIV-1 infection. (24379301)
2013
3
Cholelithiasis in obese adolescents treated at an outpatient clinic. (24361296)
2013
4
Prevalence of cholelithiasis in Buenos Aires, Argentina. (23940909)
2013
5
Study on Salmonella Typhi occurrence in gallbladder of patients suffering from chronic cholelithiasis-a predisposing factor for carcinoma of gallbladder. (23790418)
2013
6
Miniinvasive surgical management of cholelithiasis for elderly and senile patients: a retrospective study. (23863204)
2013
7
Effect of genetic variants related to lipid metabolism as risk factors for cholelithiasis after bariatric surgery in Brazilian population. (22271356)
2012
8
Does the routine echocardiographic exam have a role in the detection and evaluation of cholelithiasis and gallbladder wall thickening? (22747757)
2012
9
CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. (21628634)
2011
10
Laparoscopic removal of a double gallbladder for cholelithiasis: a case report. (21929901)
2011
11
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
12
Cholelithiasis in a neonate with chylous ascites. (20182428)
2010
13
Laparoscopic cholecystectomy for cholelithiasis in a patient with myotonic dystrophy. (19660233)
2009
14
Study of Helicobacter hepaticus in gallbladders with cholelithiasis and its sensitivity pattern. (20071844)
2009
15
Cholelithiasis in thalassemia major. (19021734)
2009
16
Cholelithiasis and cholecystitis. (19726705)
2009
17
Comment on: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence? (Eur J Pediatr 2008;167(1):109-110). (18670788)
2009
18
Perioperative management of cholelithiasis in patients presenting for laparoscopic Roux-en-Y gastric bypass: have we reached a consensus? (19545094)
2009
19
Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder. (18440760)
2008
20
Ectopic partial intrahepatic gall bladder with cholelithiasis--a rare anomaly. (18298024)
2007
21
Laparoscopic management of appendicitis and symptomatic cholelithiasis during pregnancy. (16909295)
2006
22
Clinicopathological study of cholelithiasis following gastric cancer surgery. (15818039)
2005
23
Chronic cholelithiasis with gallstones lodged in an isolated subserosal intramural gastric pouch. (15892397)
2005
24
Gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis. (16304871)
2005
25
Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease. (16044312)
2005
26
Mechanisms of acute cholelithiasis. (12631454)
2003
27
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
28
Combined needlescopic cholecystectomy and laparoscopic splenectomy for the treatment of thalassaemic splenomegaly and cholelithiasis. (14750388)
2003
29
Delay of diagnosis in pancreatic cancer due to suspected symptomatic cholelithiasis. (12523594)
2002
30
Cholelithiasis and Gilbert's syndrome in homozygous beta-thalassaemia. (11843828)
2001
31
Tract microflora in Saudi patients with cholelithiasis. (11469952)
2001
32
Cholecystectomy versus cholecystolithotomy for cholelithiasis in childhood: long-term outcome. (11584400)
2001
33
Imaging of cholelithiasis: what does the surgeon need? (11116351)
2001
34
Case 2. Cholelithiasis of the liver. (10367663)
1999
35
Similarity in gallstone formation from 900 kcal/day diets containing 16 g vs 30 g of daily fat: evidence that fat restriction is not the main culprit of cholelithiasis during rapid weight reduction. (9539651)
1998
36
Rim sign. Radionuclide imaging in a patient with acute gangrenous cholecystitis and cholelithiasis after nonspecific abdominal ultrasonography. (9193810)
1997
37
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
38
Risk of pancreatic cancer associated with cholelithiasis, cholecystectomy, or gastrectomy. (8654135)
1996
39
Cholelithiasis in children with sickle cell disease. (24057785)
1996
40
Clinical analysis of choledochoduodenal fistula with cholelithiasis in Taiwan: assessment by endoscopic retrograde cholangiopancreatography. (8561111)
1996
41
ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. (7795450)
1995
42
Incidental diagnosis of asymptomatic neonatal cholelithiasis: case report and literature review. (8558341)
1995
43
Re: "Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.)". (7653477)
1995
44
Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis. (8577230)
1995
45
Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.) (7817971)
1995
46
Low levels of hepatic cytochrome P-450 in Mexicans with uncomplicated cholelithiasis. (7839018)
1994
47
Laparoscopic cholecystectomy in complicated cholelithiasis. (7809805)
1994
48
The changing pattern of cholelithiasis in Accra. (7756184)
1994
49
The bacteriology of cholelithiasis--China versus Japan. (1787607)
1991
50
Cholelithiasis and hiatus hernia. (86699)
1979

Variations for Cholelithiasis

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Expression for genes affiliated with Cholelithiasis

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Expression patterns in normal tissues for genes affiliated with Cholelithiasis

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Pathways for genes affiliated with Cholelithiasis

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Pathways related to Cholelithiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.6UGT1A1, UGT1A5
29.5SCARB1, ABCB4
3
Show member pathways
9.3UGT1A1, UGT1A5, ABCB4
4
Show member pathways
9.2UGT1A5, UGT1A1, GUSB
5
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.2GUSB, UGT1A1, UGT1A5
6
Show member pathways
7.4ABCB4, UGT1A5, UGT1A1, GPT, GUSB, SCARB1

Compounds for genes affiliated with Cholelithiasis

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Sources:
24HMDB, 44Novoseek
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Compounds related to Cholelithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1Etiocholanolone glucuronide249.7UGT1A1, GUSB, UGT1A5
2Estrone glucuronide249.7UGT1A5, UGT1A1, GUSB
3Estriol-3-glucuronide249.7UGT1A5, UGT1A1, GUSB
4Glycochenodeoxycholic acid 3-glucuronide249.7GUSB, UGT1A1, UGT1A5
5Inodxyl glucuronide249.7GUSB, UGT1A1, UGT1A5
6Isovalerylglucuronide249.7GUSB, UGT1A1, UGT1A5
7Estriol-17-glucuronide249.7UGT1A5, GUSB, UGT1A1
8Cortolone-3-glucuronide249.7UGT1A1, UGT1A5, GUSB
9Cotinineglucuronide249.6GUSB, UGT1A1, UGT1A5
10Dehydroepiandrosterone 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
11Dehydroisoandrosterone 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
12Deoxycholic acid 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
13Ketoprofen glucuronide249.6GUSB, UGT1A1, UGT1A5
14Thyroxine glucuronide249.6UGT1A1, UGT1A5, GUSB
15trans-3-Hydroxycotinine glucuronide249.6GUSB, UGT1A1, UGT1A5
16Triiodothyronine glucuronide249.6GUSB, UGT1A1, UGT1A5
17Tyramine glucuronide249.6GUSB, UGT1A1, UGT1A5
18Valproic acid glucuronide249.6GUSB, UGT1A1, UGT1A5
19Vitamin D2 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
20Tetrahydroaldosterone-3-glucuronide249.6UGT1A5, GUSB, UGT1A1
21Lithocholate 3-O-glucuronide249.6GUSB, UGT1A1, UGT1A5
22Nicotine glucuronide249.6GUSB, UGT1A1, UGT1A5
23Octanoylglucuronide249.6GUSB, UGT1A1, UGT1A5
24Testosterone glucuronide249.6GUSB, UGT1A1, UGT1A5
25bilirubin diglucuronide44 2410.6GUSB, UGT1A1, UGT1A5
2611-Oxo-androsterone glucuronide249.6UGT1A1, UGT1A5, GUSB
2715-hydroxynorandrostene-3,17-dione glucuronide249.6GUSB, UGT1A1, UGT1A5
2816-alpha,17-beta-estriol 17-beta-D-glucuronide249.6GUSB, UGT1A1, UGT1A5
292-Methoxy-estradiol-17b 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
302-Methoxyestrone 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
312-Phenylethanol glucuronide249.5GUSB, UGT1A1, UGT1A5
3211-Hydroxyprogesterone 11-glucuronide249.5UGT1A5, GUSB, UGT1A1
33(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.5GUSB, UGT1A1, UGT1A5
341-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid249.5GUSB, UGT1A1, UGT1A5
351-Salicylate glucuronide249.5GUSB, UGT1A1, UGT1A5
3611-beta-hydroxyandrosterone-3-glucuronide249.5GUSB, UGT1A1, UGT1A5
3725-Hydroxyvitamin D2 25-(beta-glucuronide)249.5GUSB, UGT1A1, UGT1A5
384-Hydroxyandrostenedione glucuronide249.5UGT1A1, UGT1A5, GUSB
39Benzoyl glucuronide (Benzoic acid)249.4GUSB, UGT1A1, UGT1A5
40Bilirubin glucuronide249.4GUSB, UGT1A1, UGT1A5
41Cholestane-3,7,12,25-tetrol-3-glucuronide249.4GUSB, UGT1A1, UGT1A5
42Cholesterol glucuronide249.4GUSB, UGT1A1, UGT1A5
43glycocholate449.3GUSB, GPT, ABCB4
44Cholic acid glucuronide249.3GUSB, UGT1A1, UGT1A5
45lactulose449.3CCK, GUSB, GPT
463-Methoxy-4-hydroxyphenylglycol glucuronide249.3UGT1A5, GUSB, UGT1A1
4725-Hydroxyvitamin D2-25-glucuronide249.2GUSB, UGT1A1, UGT1A5
483-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide249.2GUSB, UGT1A1, UGT1A5
493,17-Androstanediol glucuronide249.1GUSB, UGT1A1, UGT1A5
503-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide248.9GUSB, UGT1A1, UGT1A5

GO Terms for genes affiliated with Cholelithiasis

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Biological processes related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6SST, UGT1A1
2digestionGO:0075869.3SST, UGT1A1
3response to drugGO:0424939.2ABCB4, UGT1A1, SST
4small molecule metabolic processGO:0442818.0SCARB1, GUSB, GPT, UGT1A1, ABCB4

Molecular functions related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:0150209.6UGT1A1, UGT1A5

Products for genes affiliated with Cholelithiasis

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  • Antibodies
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Sources for Cholelithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet