MCID: CHL004
MIFTS: 40

Cholelithiasis malady

Gastrointestinal diseases category

Aliases & Classifications for Cholelithiasis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
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Cholelithiasis, Aliases & Descriptions:

Name: Cholelithiasis 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:10211
MeSH33 D002769
ICD9CM27 574.5
ICD1025 K80

Summaries for Cholelithiasis

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MalaCards based summary: Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Steroid hormone biosynthesis and Bile secretion. The drug ursodiol and the compounds Estriol 3-sulfate 16-glucuronide and Epinephrine glucuronide have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and colon.

Related Diseases for Cholelithiasis

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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis31.3GPT, CCK
2choledocholithiasis31.0GUSB, GPT
3liver disease30.8SST, ABCB4
4pancreatitis30.8ABCB4, SST, CCK
5sickle cell disease30.8GUSB, UGT1A1
6cholestasis30.5CCK, GPT, ABCB4
7hepatitis30.5GUSB, GPT
8cholangitis30.4GPT, ABCB4
9pancreatic cancer30.3CCK, SST, PSG2
10liver cirrhosis30.3ABCB4, GPT, SST
11obesity29.9CCK, SCARB1, GPT
12acute pancreatitis29.7CCK, SST, PSG2, GPT
13colorectal cancer29.7UGT1A1, GUSB, PSG2, CCK
14obstructive jaundice29.7GPT, PSG2, CCK
15adenocarcinoma29.6CCK, SST, PSG2, GUSB, UGT1A1
16hepatocellular carcinoma29.1ABCB4, UGT1A1, GPT, SCARB1, PSG2
17crigler-najjar syndrome, type i10.5UGT1A1
18gallbladder disease 110.4
19neonatal jaundice10.3UGT1A1, GUSB
20sickle cell anemia10.3
21thalassemia10.3
22kernicterus10.3UGT1A5, UGT1A1
23pancreas disease10.3PSG2, CCK
24steatorrhea10.2CCK, SST
25gastrointestinal system disease10.2CCK, PSG2
26glucagonoma10.2SST, CCK
27short bowel syndrome10.2SST, CCK
28hiatus hernia10.2
29bilirubin metabolic disorder10.2UGT1A1, UGT1A5
30duodenal ulcer10.2SST, CCK
31peptic ulcer disease10.2SST, CCK
32paraganglioma10.1PSG2, SST
33acromegaly10.1CCK, SST
34pyruvate kinase deficiency10.1
35ascariasis10.1
36hereditary spherocytosis10.1
37appendicitis10.1
38situs inversus10.1
39choledochal cyst10.1
40down syndrome10.1
41hyperparathyroidism10.1
42myotonic dystrophy10.1
43ileus10.1
44factor vii deficiency10.1UGT1A1, PSG2, SST
45cholangitis, primary sclerosing10.1ABCB4, GPT
46gastritis10.1CCK, SST
47medullary thyroid carcinoma, familial10.1PSG2, SST, CCK
48autoimmune hepatitis10.1UGT1A1, GPT
49neuroendocrine tumor10.1PSG2, SST, CCK
50adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.0GUSB, GPT

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Symptoms for Cholelithiasis

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Drugs & Therapeutics for Cholelithiasis

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Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Cholelithiasis

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Anatomical Context for Cholelithiasis

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MalaCards organs/tissues related to Cholelithiasis:

31
Liver, Heart, Colon, Kidney, Pancreas, Bone marrow, Bone, Spleen, Spinal cord, Smooth muscle, Small intestine, Breast, Ovary, Prostate, B cells

Animal Models for Cholelithiasis or affiliated genes

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Publications for Cholelithiasis

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Articles related to Cholelithiasis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Obstructive cholelithiasis and cholecystitis in a kinkajou (Potos flavus). (25831597)
2015
2
Adrenal myelolipoma, cholelithiasis and calcified spleen: retrospective diagnosis of sickle cell anemia using a novel triad of abdominal imaging findings. (25053687)
2014
3
Cumulative exposure to ritonavir-boosted atazanavir is associated with cholelithiasis in patients with HIV-1 infection. (24379301)
2013
4
Cholelithiasis in obese adolescents treated at an outpatient clinic. (24361296)
2013
5
Prevalence of cholelithiasis in Buenos Aires, Argentina. (23940909)
2013
6
Study on Salmonella Typhi occurrence in gallbladder of patients suffering from chronic cholelithiasis-a predisposing factor for carcinoma of gallbladder. (23790418)
2013
7
Effect of genetic variants related to lipid metabolism as risk factors for cholelithiasis after bariatric surgery in Brazilian population. (22271356)
2012
8
Does the routine echocardiographic exam have a role in the detection and evaluation of cholelithiasis and gallbladder wall thickening? (22747757)
2012
9
CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. (21628634)
2011
10
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
11
Cholelithiasis in a neonate with chylous ascites. (20182428)
2010
12
Laparoscopic cholecystectomy for cholelithiasis in a patient with myotonic dystrophy. (19660233)
2009
13
Study of Helicobacter hepaticus in gallbladders with cholelithiasis and its sensitivity pattern. (20071844)
2009
14
Cholelithiasis in thalassemia major. (19021734)
2009
15
Cholelithiasis and cholecystitis. (19726705)
2009
16
Comment on: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence? (Eur J Pediatr 2008;167(1):109-110). (18670788)
2009
17
Perioperative management of cholelithiasis in patients presenting for laparoscopic Roux-en-Y gastric bypass: have we reached a consensus? (19545094)
2009
18
Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder. (18440760)
2008
19
Ectopic partial intrahepatic gall bladder with cholelithiasis--a rare anomaly. (18298024)
2007
20
Laparoscopic management of appendicitis and symptomatic cholelithiasis during pregnancy. (16909295)
2006
21
Clinicopathological study of cholelithiasis following gastric cancer surgery. (15818039)
2005
22
Chronic cholelithiasis with gallstones lodged in an isolated subserosal intramural gastric pouch. (15892397)
2005
23
Gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis. (16304871)
2005
24
Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease. (16044312)
2005
25
Mechanisms of acute cholelithiasis. (12631454)
2003
26
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
27
Combined needlescopic cholecystectomy and laparoscopic splenectomy for the treatment of thalassaemic splenomegaly and cholelithiasis. (14750388)
2003
28
Delay of diagnosis in pancreatic cancer due to suspected symptomatic cholelithiasis. (12523594)
2002
29
Cholelithiasis and Gilbert's syndrome in homozygous beta-thalassaemia. (11843828)
2001
30
Tract microflora in Saudi patients with cholelithiasis. (11469952)
2001
31
Cholecystectomy versus cholecystolithotomy for cholelithiasis in childhood: long-term outcome. (11584400)
2001
32
Imaging of cholelithiasis: what does the surgeon need? (11116351)
2001
33
Case 2. Cholelithiasis of the liver. (10367663)
1999
34
Similarity in gallstone formation from 900 kcal/day diets containing 16 g vs 30 g of daily fat: evidence that fat restriction is not the main culprit of cholelithiasis during rapid weight reduction. (9539651)
1998
35
Rim sign. Radionuclide imaging in a patient with acute gangrenous cholecystitis and cholelithiasis after nonspecific abdominal ultrasonography. (9193810)
1997
36
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
37
Risk of pancreatic cancer associated with cholelithiasis, cholecystectomy, or gastrectomy. (8654135)
1996
38
Cholelithiasis in children with sickle cell disease. (24057785)
1996
39
Clinical analysis of choledochoduodenal fistula with cholelithiasis in Taiwan: assessment by endoscopic retrograde cholangiopancreatography. (8561111)
1996
40
ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. (7795450)
1995
41
Incidental diagnosis of asymptomatic neonatal cholelithiasis: case report and literature review. (8558341)
1995
42
Re: "Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.)". (7653477)
1995
43
Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis. (8577230)
1995
44
Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.) (7817971)
1995
45
Low levels of hepatic cytochrome P-450 in Mexicans with uncomplicated cholelithiasis. (7839018)
1994
46
Laparoscopic cholecystectomy in complicated cholelithiasis. (7809805)
1994
47
The changing pattern of cholelithiasis in Accra. (7756184)
1994
48
The bacteriology of cholelithiasis--China versus Japan. (1787607)
1991
49
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)
1982
50
Cholelithiasis and hiatus hernia. (86699)
1979

Variations for Cholelithiasis

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Expression for genes affiliated with Cholelithiasis

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Search GEO for disease gene expression data for Cholelithiasis.

Pathways for genes affiliated with Cholelithiasis

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Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.6UGT1A1, UGT1A5
29.5SCARB1, ABCB4
3
Show member pathways
9.3UGT1A1, UGT1A5, ABCB4
4
Show member pathways
9.2UGT1A5, UGT1A1, GUSB
5
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.2GUSB, UGT1A1, UGT1A5
6
Show member pathways
7.4ABCB4, UGT1A5, UGT1A1, GPT, GUSB, SCARB1

Compounds for genes affiliated with Cholelithiasis

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Sources:
24HMDB, 43Novoseek
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Compounds related to Cholelithiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1Estriol 3-sulfate 16-glucuronide249.7UGT1A1, GUSB, UGT1A5
2Epinephrine glucuronide249.7UGT1A5, UGT1A1, GUSB
3Dopamine glucuronide249.7UGT1A5, UGT1A1, GUSB
4Glycochenodeoxycholic acid 3-glucuronide249.7GUSB, UGT1A1, UGT1A5
5Inodxyl glucuronide249.7GUSB, UGT1A1, UGT1A5
6Isovalerylglucuronide249.7GUSB, UGT1A1, UGT1A5
7Dextrorphan O-glucuronide249.7UGT1A5, GUSB, UGT1A1
8Cortolone-3-glucuronide249.7UGT1A1, UGT1A5, GUSB
9Cotinineglucuronide249.6GUSB, UGT1A1, UGT1A5
10Dehydroepiandrosterone 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
11Dehydroisoandrosterone 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
12Deoxycholic acid 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
13Ketoprofen glucuronide249.6GUSB, UGT1A1, UGT1A5
14Pregnanediol-3-glucuronide249.6UGT1A1, UGT1A5, GUSB
15trans-3-Hydroxycotinine glucuronide249.6GUSB, UGT1A1, UGT1A5
16Triiodothyronine glucuronide249.6GUSB, UGT1A1, UGT1A5
17Tyramine glucuronide249.6GUSB, UGT1A1, UGT1A5
18Valproic acid glucuronide249.6GUSB, UGT1A1, UGT1A5
19Vitamin D2 3-glucuronide249.6GUSB, UGT1A1, UGT1A5
20Phenethylamine glucuronide249.6UGT1A5, GUSB, UGT1A1
21Lithocholate 3-O-glucuronide249.6GUSB, UGT1A1, UGT1A5
22Nicotine glucuronide249.6GUSB, UGT1A1, UGT1A5
23Octanoylglucuronide249.6GUSB, UGT1A1, UGT1A5
24Palmitoyl glucuronide249.6GUSB, UGT1A1, UGT1A5
25(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.6GUSB, UGT1A1, UGT1A5
2615-hydroxynorandrostene-3,17-dione glucuronide249.6UGT1A1, UGT1A5, GUSB
2716-alpha,17-beta-estriol 17-beta-D-glucuronide249.6GUSB, UGT1A1, UGT1A5
2817-alpha-estradiol-3-glucuronide249.6GUSB, UGT1A1, UGT1A5
2917-beta-estradiol glucuronide249.6GUSB, UGT1A1, UGT1A5
3017-beta-estradiol-3-glucuronide249.6GUSB, UGT1A1, UGT1A5
3125-Hydroxyvitamin D2 25-(beta-glucuronide)249.5GUSB, UGT1A1, UGT1A5
3211-Oxo-androsterone glucuronide249.5UGT1A5, GUSB, UGT1A1
331-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid249.5GUSB, UGT1A1, UGT1A5
341-Salicylate glucuronide249.5GUSB, UGT1A1, UGT1A5
3511-beta-hydroxyandrosterone-3-glucuronide249.5GUSB, UGT1A1, UGT1A5
3611-Hydroxyprogesterone 11-glucuronide249.5GUSB, UGT1A1, UGT1A5
3725-Hydroxyvitamin D2-25-glucuronide249.5GUSB, UGT1A1, UGT1A5
385-alpha-Dihydrotestosterone glucuronide249.5UGT1A1, UGT1A5, GUSB
395-Hydroxy-6-methoxyindole glucuronide249.4GUSB, UGT1A1, UGT1A5
406-Dehydrotestosterone glucuronide249.4GUSB, UGT1A1, UGT1A5
416-Hydroxy-5-methoxyindole glucuronide249.4GUSB, UGT1A1, UGT1A5
42Cholesterol glucuronide249.4GUSB, UGT1A1, UGT1A5
43glycocholate439.3GUSB, GPT, ABCB4
44Cholic acid glucuronide249.3GUSB, UGT1A1, UGT1A5
45lactulose439.3CCK, GUSB, GPT
464-Hydroxyandrostenedione glucuronide249.3UGT1A5, GUSB, UGT1A1
473,17-Androstanediol glucuronide249.2GUSB, UGT1A1, UGT1A5
483-Methoxy-4-hydroxyphenylglycol glucuronide249.2GUSB, UGT1A1, UGT1A5
493-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide249.1GUSB, UGT1A1, UGT1A5
503-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide248.9GUSB, UGT1A1, UGT1A5

GO Terms for genes affiliated with Cholelithiasis

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Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:00075849.6SST, UGT1A1
2digestionGO:00075869.3SST, UGT1A1
3response to drugGO:00424939.2ABCB4, UGT1A1, SST
4small molecule metabolic processGO:00442818.0SCARB1, GUSB, GPT, UGT1A1, ABCB4

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:00150209.6UGT1A1, UGT1A5

Products for genes affiliated with Cholelithiasis

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Sources for Cholelithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet