MCID: CHL004
MIFTS: 51

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 72 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 34 574.5
SNOMED-CT 64 197397004 266475002
ICD10 32 K80

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Benzocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and pancreas, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 72 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 31.2 ABCB4 ALB CCK GPT
2 choledocholithiasis 30.4 ABCB4 ALB GPT UGT1A1
3 sickle cell anemia 30.0 HBB UGT1A1 UGT1A6
4 cholangitis 29.9 ABCB4 ALB GPT
5 liver disease 29.9 ABCB4 ALB GPT NR1H4
6 intrahepatic cholestasis 29.9 ABCB4 ALB NR1H4
7 liver cirrhosis 29.9 ALB GPT SST
8 postcholecystectomy syndrome 29.8 CCK SST
9 ascending cholangitis 29.7 ALB CCK
10 duodenogastric reflux 29.7 CCK SST
11 acute pancreatitis 29.6 CCK CCKAR SST
12 cholestasis 29.5 ABCB4 CYP7A1 GPT NR1H4
13 portal hypertension 29.4 ALB GPT SST
14 bilirubin metabolic disorder 29.4 ALB GPT UGT1A1 UGT1A6
15 aortic atherosclerosis 29.3 ABCG5 ABCG8 APOE
16 body mass index quantitative trait locus 11 29.3 APOE CCK CCKAR GPT NR1H4
17 biliary tract disease 28.6 ABCB4 ALB CCK CYP7A1 NR1H4
18 gallbladder disease 28.2 ABCB4 ABCG8 APOE CCK CCKAR SST
19 gallbladder disease 1 12.1
20 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.1
21 spherocytosis, type 1 10.8
22 overhydrated hereditary stomatocytosis 10.8
23 bisphosphoglycerate mutase deficiency 10.8
24 duodenal atresia 10.8
25 beta-thalassemia, dominant inclusion body type 10.8
26 gallbladder disease 4 10.8
27 spherocytosis, type 2 10.8
28 dehydrated hereditary stomatocytosis 2 10.8
29 clonorchiasis 10.8
30 cholestasis, progressive familial intrahepatic, 1 10.4 ABCB4 NR1H4
31 familial lcat deficiency 10.4 ALB APOE
32 yellow nail syndrome 10.3 ALB SST
33 paralytic ileus 10.3 ALB CCK
34 crigler-najjar syndrome, type ii 10.3 UGT1A1 UGT1A6
35 splenic disease 10.3 ALB HBB
36 chylothorax, congenital 10.3 ALB SST
37 glucosephosphate dehydrogenase deficiency 10.3 HBB UGT1A1
38 descending colon cancer 10.3 UGT1A1 UGT1A6
39 kwashiorkor 10.3 ALB GPT
40 hepatic tuberculosis 10.3 ALB GPT
41 hepatic coma 10.2 ALB GPT
42 esophageal varix 10.2 ALB SST
43 pancreatic cholera 10.2 CCK SST
44 pancreatitis 10.2
45 biliary atresia 10.1 ALB GPT NR1H4
46 kernicterus 10.1 ALB UGT1A1 UGT1A6
47 opioid abuse 10.1 CCK CCKAR
48 sickle cell disease 10.1
49 pigmentation disease 10.1 UGT1A1 UGT1A6
50 binswanger's disease 10.0 APOE SST

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.81 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
2 homeostasis/metabolism MP:0005376 9.7 CYP7A1 NR1H4 SCARB1 SST ABCB4 ABCG5
3 liver/biliary system MP:0005370 9.28 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 225)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
10
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
13
Acetaminophen Approved Phase 4 103-90-2 1983
14
Clonidine Approved Phase 4 4205-90-7 2803
15 Nefopam Approved, Investigational Phase 4 13669-70-0
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2 128-13-2 31401
18
Ondansetron Approved Phase 4 99614-02-5 4595
19
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
20
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
23
Ephedrine Approved Phase 4 299-42-3 9294
24
Esmolol Approved Phase 4 81147-92-4, 103598-03-4 59768
25
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
26
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
27
Morphine Approved, Investigational Phase 4 57-27-2 5288826
28
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
29
Pseudoephedrine Approved Phase 4 90-82-4 7028
30
Etomidate Approved Phase 4 33125-97-2 667484 36339
31
Meperidine Approved Phase 4 57-42-1 4058
32
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
33
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
34
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
35
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
36
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
37
Sulbactam Approved Phase 4 68373-14-8
38 Sultamicillin Approved, Investigational Phase 4 76497-13-7
39 tannic acid Approved, Nutraceutical Phase 4
40 Analgesics Phase 4
41 Analgesics, Opioid Phase 4
42 Anesthetics Phase 4,Phase 1,Phase 2
43 Anesthetics, General Phase 4
44 Anesthetics, Intravenous Phase 4
45 Central Nervous System Depressants Phase 4,Phase 1
46 Hypnotics and Sedatives Phase 4,Phase 1
47 Narcotics Phase 4
48 Peripheral Nervous System Agents Phase 4,Phase 1
49 Adjuvants, Anesthesia Phase 4
50 Anesthetics, Dissociative Phase 4

Interventional clinical trials:

(show top 50) (show all 261)

# Name Status NCT ID Phase Drugs
1 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
2 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
3 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
4 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
6 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
7 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
8 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
9 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
10 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
11 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
12 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
13 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
14 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
15 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
16 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
17 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
18 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
19 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
20 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
21 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
22 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
23 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
24 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
25 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
26 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
27 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
28 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
29 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
30 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4 Tauroursodeoxycholic acid
31 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Recruiting NCT03168555 Phase 4 chenodeoxycholic acid
32 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
33 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
34 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
35 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
36 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
37 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
38 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
39 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
40 Indications for Gallbladder Surgery in Gallstone Disease Completed NCT01190280 Phase 3
41 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
42 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
43 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
44 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
45 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
46 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
47 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
48 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
49 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
50 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Recruiting NCT02490111 Phase 3 DWJ1319;Placebo

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 28

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

38
Liver, Skin, Pancreas, Kidney, Bone, Heart, Colon

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 668)
# Title Authors Year
1
Ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 29301452 )
2018
2
Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. ( 29266548 )
2018
3
Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease? ( 28567595 )
2017
4
Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs. ( 29088261 )
2017
5
Cholelithiasis ( 29262107 )
2017
6
Cholelithiasis in a Patient With History of Cholecystectomy. ( 28870658 )
2017
7
Cholelithiasis. ( 28745992 )
2017
8
Intrahepatic cholelithiasis in dogs and cats: A case series. ( 28878422 )
2017
9
Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study. ( 28353587 )
2017
10
Cholelithiasis in adult bearded dragons: retrospective study of nine adult bearded dragons (Pogona vitticeps) with cholelithiasis between 2013 and 2015 in southern Germany. ( 28627055 )
2017
11
Effectiveness of Ultrasound Shear for Clipless Laparoscopic Cholecystectomy Versus Conventional Unipolar Electrocautery in Patients with Cholelithiasis. ( 29056121 )
2017
12
Laparoscopic cholecystectomy for cholelithiasis in children with sickle cell disease. ( 28555355 )
2017
13
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
14
Cholecystoduodenal fistula, an infrequent complication of cholelithiasis: Our experience in its surgical management. ( 28389051 )
2017
15
Miniinvasive surgical interventions in management of cholelithiasis A retrospective study. ( 28604381 )
2017
16
Cholelithiasis - always infected? ( 28703118 )
2017
17
Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. ( 28244632 )
2017
18
Single Stage Management of Concomitant Cholelithiasis and Choledocholithiasis. ( 28598447 )
2017
19
Cholecystolithotomy Combined Armillarisin A versus Cholecystectomy in Cirrhotic Portal Hypertension Patients with Symptomatic Cholelithiasis. ( 28463673 )
2017
20
Etiology and Outcome of Cholelithiasis in Turkish Children. ( 29242416 )
2017
21
Is Concomitant Cholecystectomy Necessary for Asymptomatic Cholelithiasis During Laparoscopic Sleeve Gastrectomy? ( 28803397 )
2017
22
Cholelithiasis and its complications in sickle cell disease in a university hospital. ( 28270342 )
2017
23
Don't put off until tomorrow what you can do today: Early cholecystectomy is cost-effective in symptomatic cholelithiasis requiring hospitalization. ( 29133302 )
2017
24
Physical Chemistry of Bile: Detailed Pathogenesis of Cholelithiasis. ( 28350710 )
2017
25
Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. ( 28383429 )
2017
26
Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy - A Case Report and Review of the Literature. ( 28210714 )
2017
27
Pre- and Post-operative Comparative Analysis of Serum Lipid Profile in Patients with Cholelithiasis. ( 28904919 )
2017
28
COMMENT: HOSPITALIZATIONS FOR CHOLECYSTITIS AND CHOLELITHIASIS IN THE STATE OF RIO GRANDE DO SUL, BRAZILREPLY. ( 28076493 )
2016
29
Response to: Serum paraoxonase and malondialdehyde levels in asymptomatic cholelithiasis. ( 26831617 )
2016
30
Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient. ( 27746433 )
2016
31
Pregnane receptor gene polymorphisms, pathogenic bacteria distribution and drug sensitivity, and TCM syndrome differentiation in patients with cholelithiasis. ( 27086146 )
2016
32
HOSPITALIZATIONS FOR CHOLECYSTITIS AND CHOLELITHIASIS IN THE STATE OF RIO GRANDE DO SUL, BRAZIL. ( 27438030 )
2016
33
Severe acute hemorrhagic pancreatitis secondary to cholelithiasis as a rare cause of sudden unexpected death in medico-legal case: A case report. ( 27559973 )
2016
34
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. ( 27033116 )
2016
35
Endoscopic management of choledocholithiasis and cholelithiasis in patients with cirrhosis. ( 26799755 )
2016
36
Comment on "The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia". ( 26813445 )
2016
37
Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. ( 27891394 )
2016
38
The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study. ( 27063855 )
2016
39
Evidence-based clinical practice guidelines for cholelithiasis 2016. ( 27942871 )
2016
40
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
41
The Progression of Cholelithiasis to Gallstone Ileus: Do Large Gallstones Warrant Surgery? ( 26857589 )
2016
42
Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder. ( 27376020 )
2016
43
Corrigendum to "The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study" [Int. J. Surg. 30 (2016) 13-18]. ( 27693476 )
2016
44
Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population. ( 27995261 )
2016
45
Acute pain management in symptomatic cholelithiasis. ( 27830044 )
2016
46
To leave no stone unturned: cholelithiasis and subsequent gallstone ileus. ( 27154989 )
2016
47
Possible Atazanavir-Induced Cholelithiasis in a Pregnant Woman: A Case Report. ( 27621492 )
2016
48
Frequency of Cholelithiasis and Biliary Pathology in the Easter Island Rapanui and Non-Rapanui Populations. ( 27039794 )
2016
49
Risk Factors for Cholelithiasis. ( 27467059 )
2016
50
Spontaneous Cholelithiasis in a Squirrel Monkey (Saimiri sciureus). ( 26884412 )
2016

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 ABCB4 ABCG5 ABCG8 ALB APOE CYP7A1
2
Show member pathways
12.34 ABCG5 ABCG8 ALB APOE SCARB1
3 12.29 APOE HBB UGT1A1 UGT1A6
4
Show member pathways
12.11 ALB APOE HBB SCARB1
5
Show member pathways
11.69 ALB APOE HBB SCARB1
6
Show member pathways
11.63 ABCG5 ABCG8 APOE CYP7A1 SCARB1
7
Show member pathways
11.48 CYP7A1 UGT1A1 UGT1A6
8
Show member pathways
11.28 ABCG5 ABCG8 SCARB1
9 11.25 ABCG5 ABCG8 SCARB1
10 10.95 ABCB4 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1
11 10.8 ABCB4 ABCG5 CYP7A1 NR1H4
12 10.75 CYP7A1 NR1H4
13 10.71 ABCB4 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 ABCB4 ABCG5 ABCG8 CCKAR SCARB1 UGT1A1
2 endocytic vesicle lumen GO:0071682 8.96 APOE HBB
3 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG5 ABCG8

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 ABCB4 ABCG5 ABCG8 SST UGT1A1
2 lipid transport GO:0006869 9.8 ABCB4 APOE SCARB1
3 receptor-mediated endocytosis GO:0006898 9.8 ALB APOE HBB SCARB1
4 steroid metabolic process GO:0008202 9.78 APOE CYP7A1 UGT1A1
5 cellular oxidant detoxification GO:0098869 9.7 ALB APOE HBB
6 digestion GO:0007586 9.69 CCKAR SST UGT1A1
7 drug transmembrane transport GO:0006855 9.63 ABCB4 ABCG5
8 reverse cholesterol transport GO:0043691 9.62 APOE SCARB1
9 positive regulation of nitric-oxide synthase activity GO:0051000 9.61 APOE SCARB1
10 intestinal absorption GO:0050892 9.6 ABCB4 SCARB1
11 cellular glucuronidation GO:0052695 9.59 UGT1A1 UGT1A6
12 fatty acid homeostasis GO:0055089 9.58 APOE NR1H4
13 regulation of cholesterol metabolic process GO:0090181 9.58 APOE NR1H4
14 intestinal cholesterol absorption GO:0030299 9.57 ABCG5 ABCG8
15 high-density lipoprotein particle clearance GO:0034384 9.56 APOE SCARB1
16 flavonoid glucuronidation GO:0052696 9.55 UGT1A1 UGT1A6
17 xenobiotic glucuronidation GO:0052697 9.54 UGT1A1 UGT1A6
18 triglyceride homeostasis GO:0070328 9.54 APOE NR1H4 SCARB1
19 high-density lipoprotein particle remodeling GO:0034375 9.5 ALB APOE SCARB1
20 regulation of bile acid biosynthetic process GO:0070857 9.48 CYP7A1 NR1H4
21 cholesterol efflux GO:0033344 9.46 ABCG5 ABCG8 APOE SCARB1
22 negative regulation of intestinal cholesterol absorption GO:0045796 9.43 ABCG5 ABCG8
23 cholesterol catabolic process GO:0006707 9.43 APOE CYP7A1 SCARB1
24 negative regulation of intestinal phytosterol absorption GO:0010949 9.4 ABCG5 ABCG8
25 response to nutrient GO:0007584 9.35 ABCG5 ABCG8 CCKAR SST UGT1A1
26 cholesterol homeostasis GO:0042632 9.02 ABCG5 ABCG8 APOE CYP7A1 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.32 UGT1A1 UGT1A6
2 antioxidant activity GO:0016209 9.26 ALB APOE
3 retinoic acid binding GO:0001972 9.16 UGT1A1 UGT1A6
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB4 ABCG5 ABCG8
5 cholesterol transporter activity GO:0017127 8.8 ABCG5 ABCG8 APOE

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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