MCID: CHL004
MIFTS: 51

Cholelithiasis malady

Summaries for Cholelithiasis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are nicotine degradation III and thyroid hormone metabolism II (via conjugation and/or degradation). The drug ursodiol and the compounds sn38 glucuronide and lamotrigine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Cholelithiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cholelithiasis 8 10 44 60


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Disease Ontology8 DOID:10211
ICD9CM27 574.5
MeSH34 D002769

Related Diseases for Cholelithiasis

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17GeneCards, 18GeneDecks
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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis30.9GPT, CCK
2choledocholithiasis30.7GUSB, GPT, GGT1
3pancreatitis30.5CCKAR, CCK, UGT1A7, SST, ABCB4, GGT1
4hepatitis30.5GUSB, GPT, GGT1
5cholestasis30.4GGT1, ABCB4, GPT, CCK
6liver cirrhosis30.4GGT1, GPT, GUSB
7obesity30.3CCKAR, CCK, SCARB1, GPT, GGT1
8acute pancreatitis30.2CCKAR, CCK, PSG2, SST, GPT
9cholangitis30.2GPT, ABCB4, GGT1
10gallbladder disease30.2CCKAR, CCK
11gallbladder cancer30.1CDX2, PSG2
12pancreatic cancer30.1CCKAR, CCK, SST, CDX2, SERPINB5
13gilbert syndrome29.9UGT1A4, UGT1A1, UGT1A7
14adenoma29.9PSG2, SCARB1, SST, CDX2, GGT1, SERPINB5
15adenocarcinoma29.9CCKAR, CCK, PSG2, GUSB, UGT1A1, UGT1A7
16esophagitis29.7CDX2
17alpha thalassemia29.7UGT1A1
18atherosclerosis29.7SCARB1, LPXN, GGT1
19obstructive jaundice29.7CCK, PSG2, GPT, GGT1
20bile reflux29.7CCK
21prostate cancer29.7SERPINB5, CDX2
22colon cancer29.7CCKAR, PSG2, GUSB, UGT1A1, UGT1A10, CDX2
23breast cancer29.7PSG2, UGT1A1, CDX2, ABCB4, SULT1E1, SERPINB5
24colorectal cancer29.7PSG2, GUSB, CDX2, SERPINB5
25sickle cell disease10.3
26gallbladder disease 110.3
27liver disease10.2
28hiatus hernia10.2
29thalassemia10.2
30sickle cell anemia10.1
31hereditary spherocytosis10.1
32ascariasis10.1
33appendicitis10.1
34situs inversus10.1
35choledochal cyst10.1
36down syndrome10.1
37hyperparathyroidism10.1
38myotonic dystrophy10.1
39cystic fibrosis10.0GUSB
40constipation10.0CCK
41familial adenomatous polyposis10.0CDX2
42diarrhea10.0UGT1A1, SST
43anorexia nervosa10.0CCK
44protein-energy malnutrition10.0CCK
45pituitary adenoma10.0SST
46coronary heart disease10.0GGT1, SCARB1
47dyspepsia10.0CCK
48crigler najjar syndrome, type 210.0UGT1A4, UGT1A1
49endometrial carcinoma10.0SULT1E1, PSG2
50crigler-najjar syndrome10.0UGT1A4, UGT1A1

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Clinical Features for Cholelithiasis

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Drugs & Therapeutics for Cholelithiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cholelithiasis

Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

Search NIH Clinical Center for Cholelithiasis

Search CenterWatch for Cholelithiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cholelithiasis

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Anatomical Context for Cholelithiasis

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32MalaCards
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MalaCards organs/tissues related to Cholelithiasis:

32
Liver, Heart, Kidney, Colon, Pancreas, Testes, Prostate, Ovary, Breast, Bone marrow, Small intestine, Smooth muscle, Spinal cord, Bone, B cells

Animal Models for Cholelithiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cholelithiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1SULT1E1, ABCB4, CDX2, GUSB, SCARB1, CCK

Publications for Cholelithiasis

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50PubMed
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Articles related to Cholelithiasis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Cumulative exposure to ritonavir-boosted atazanavir is associated with cholelithiasis in patients with HIV-1 infection. (24379301)
2013
2
MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha. (22569176)
2012
3
Cholelithiasis in a patient with an anatomical variation of the cystic duct. (22933255)
2012
4
Gall Bladder Metastasis from Breast Cancer Masquerading Symptomatic Cholelithiasis. (22418771)
2012
5
Cost-effective treatment of patients with symptomatic cholelithiasis and possible common bile duct stones. (21444220)
2011
6
Education and imaging. Gastrointestinal: gallbladder carcinoma and cholelithiasis: a radiologic--pathologic correlation. (21884249)
2011
7
Occurrence of cholelithiasis and cholecystitis in amyotrophic lateral sclerosis patients with long-term tracheostomy invasive ventilation. (22001453)
2011
8
Gallstone ileus of the sigmoid colon: a rare complication of cholelithiasis. (21394537)
2011
9
Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study. (21999925)
2011
10
Prevalence of cholelithiasis in patients subjected to liver transplantation for cirrhosis. (21188332)
2010
11
Cholelithiasis in gallbladder cancer: coincidence, cofactor, or cause! (20537839)
2010
12
Ceftriaxone-associated cholelithiasis: 30 min drip infusion versus bolus injection. (21166949)
2010
13
The culture site of the gallbladder affects recovery of bacteria in symptomatic cholelithiasis. (18568139)
2008
14
Two-stage treatment with preoperative endoscopic retrograde cholangiopancreatography (ERCP) compared with single-stage treatment with intraoperative ERCP for patients with symptomatic cholelithiasis with possible choledocholithiasis. (17001567)
2006
15
Clinical and laboratory indices of cholelithiasis in adult Nigerians with sickle-cell anaemia. (16483434)
2006
16
Gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis. (16304871)
2005
17
Gallbladder reefing for cholelithiasis as a complication of colon cancer. (15782992)
2005
18
Reappraisal of the management of cholelithiasis in diabetics. (16311649)
2005
19
Treatment of suspected symptomatic cholelithiasis with glycopyrrolate: a prospective, randomized clinical trial. (15671975)
2005
20
A variant of the double gallbladder. A possible cause of cholelithiasis? (16228961)
2005
21
Endoscopic ultrasonography in detection of cholelithiasis in patients with biliary pain and negative transabdominal ultrasonography. (15074397)
2004
22
A human fasciolosis presenting with cholelithiasis and choledocholithiasis in Van, Turkey. (15573215)
2004
23
Mechanisms of acute cholelithiasis. (12631454)
2003
24
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
25
Clinical epidemiological study on intrahepatic cholelithiasis: analysis of 8585 cases. (14599985)
2003
26
Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. (12091495)
2002
27
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. (11313316)
2001
28
Cholelithiasis in Down's syndrome. (11517110)
2001
29
Autonomic dysfunction and cholelithiasis in patients with cirrhosis. (11318521)
2001
30
Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. (11878580)
2001
31
Radiographic diagnosis: pericardioperitoneal diaphragmatic hernia and cholelithiasis in a dog. (11499705)
2001
32
Cholelithiasis: genetic hypothesis. (16498349)
2000
33
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes. (10553011)
1999
34
Predictive factors for cholelithiasis complications. (10568123)
1999
35
Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome. (9630042)
1998
36
Cholelithiasis and acute cholecystitis. (9512803)
1997
37
Sequential endoscopic/laparoscopic management of cholelithiasis and choledocholithiasis in children who have sickle cell disease. (9349762)
1997
38
Laparoscopic cholecystectomy: The treatment of choice for cholelithiasis in infancy and childhood. (17353591)
1997
39
Infant cholelithiasis: report of a case. (9035305)
1997
40
Cholelithiasis in children with sickle cell disease. (24057785)
1996
41
Selections from current literature: cholelithiasis, cholecystectomy and the risk of colorectal cancer. (8902519)
1996
42
Role of endoscopic sphincterotomy alone in patients with choledocholithiasis and cholelithiasis. (8640622)
1996
43
Gallbladder stones analyzes, bile and wound cultures in cholelithiasis. (19864823)
1996
44
Laparoscopic cholecystectomy for cholelithiasis in patients with liver cirrhosis. (18493357)
1995
45
Cholelithiasis and bile acid absorption after truncal vagotomy and gastroenterostomy. (7922058)
1994
46
Chronic treatment with a long-acting somatostatin analogue in a patient with intestinal carcinoid tumor: occurrence of cholelithiasis. (2319110)
1990
47
Two cases of left-sided gallbladder associated with cholelithiasis: review of the literature in Japan. (3047621)
1988
48
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)
1982
49
Cholelithiasis, diverticular disease and hiatus hernia in a Rhodesian African. (5034236)
1972
50
Metachromatic leukodystrophy. A cause of cholelithiasis in childhood. (5805232)
1969

Genetic Variations for Cholelithiasis

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Expression for genes affiliated with Cholelithiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for genes affiliated with Cholelithiasis

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37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4UGT1A10, UGT1A4
210.4UGT1A3, UGT1A10
3
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10.3UGT1A3, UGT1A10, UGT1A1
410.3UGT1A4, UGT1A10, UGT1A3
5
Hide members
10.3UGT1A4, UGT1A1, UGT1A3, SULT1E1
6
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10.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
7
Hide members
10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
8
Acetaminophen metabolism
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10.2UGT1A4, UGT1A1, UGT1A10, UGT1A3, SULT1E1
9
Hide members
10.2UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7, UGT1A3
10
Hide members
10.1GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7
11
Hide members
10.1SCARB1, GUSB, UGT1A4, UGT1A1, UGT1A5, UGT1A10
12
Hide members
10.1SULT1E1, UGT1A4, UGT1A1, UGT1A5, UGT1A10, UGT1A7

Compounds for genes affiliated with Cholelithiasis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cholelithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1sn38 glucuronide4410.7GUSB, UGT1A7, UGT1A1
2lamotrigine44 1111.7UGT1A1, UGT1A3, UGT1A4, GUSB
3n-hydroxy phip4410.7UGT1A4, UGT1A1, UGT1A10, UGT1A7
4ezetimibe44 1111.7UGT1A3, UGT1A1, SCARB1, GPT
5loxiglumide4410.7SST, CCKAR, CCK
6p-nitrophenol44 1111.7UGT1A4, UGT1A1, UGT1A3, SULT1E1
7Ezogabine 1110.6UGT1A4, UGT1A3, UGT1A1
8propofol44 49 1112.6UGT1A3, UGT1A4, UGT1A10, UGT1A1
9uridine diphosphate4410.6UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4
10lactulose4410.6GPT, GUSB, CCK
11glucuronide4410.6UGT1A3, GUSB, UGT1A1, UGT1A10, UGT1A7, UGT1A4
12udp glucuronic acid4410.6GUSB, UGT1A1, UGT1A10
13cotinine44 2411.6UGT1A4, UGT1A1, GUSB, UGT1A10, UGT1A7, UGT1A3
14ursodeoxycholic acid44 11 2412.6GGT1, ABCB4, GPT, CCK
15imipramine44 49 28 11 2414.6UGT1A7, UGT1A4, UGT1A1, UGT1A3, UGT1A10
16glycocholate4410.6GUSB, GPT, ABCB4
17etiocholanolone44 2411.6UGT1A4, UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1
18silymarin4410.6UGT1A1, GUSB, GPT, GGT1
19estriol28 11 2412.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
20androsterone glucuronide44 2411.6UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1
213-alpha-androstanediol glucuronide44 2411.6GUSB, UGT1A3, UGT1A4, UGT1A1, UGT1A5, UGT1A10
222-methoxyestradiol44 59 2412.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A4, UGT1A1
23morphine44 49 28 1113.6UGT1A3, CCK, CCKAR, GUSB, UGT1A4, UGT1A1
24(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)2410.6GUSB, UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1
25aldosterone 18-glucuronide44 2411.6UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
26bilirubin diglucuronide44 2411.6UGT1A4, GUSB, UGT1A1, UGT1A5, UGT1A3, UGT1A7
27mycophenolate mofetil44 49 1112.6GGT1, UGT1A10, UGT1A1, GPT
28troglitazone44 28 59 1113.6UGT1A4, GPT, UGT1A3, UGT1A1, UGT1A10
29codeine44 49 28 11 2414.6UGT1A7, UGT1A4, UGT1A5, UGT1A1, UGT1A10, UGT1A3
30estrogen4410.6ABCB4, UGT1A4, UGT1A10
31ethyl glucuronide44 2411.6UGT1A3, GGT1, GUSB, UGT1A4, UGT1A1, UGT1A10
32estrone44 28 11 2413.5SULT1E1, UGT1A5, UGT1A3, UGT1A7, UGT1A10, UGT1A1
33valproic acid44 49 11 2413.5UGT1A7, UGT1A10, GGT1, GPT, UGT1A3, UGT1A4
34nicotine44 49 28 1113.5UGT1A3, GPT, GGT1, UGT1A10, UGT1A4, UGT1A1
35cyproheptadine28 44 1112.5UGT1A3, SST, CCK
36quercetin44 59 11 2413.5UGT1A3, UGT1A1, GUSB, SULT1E1, GGT1
37acetaminophen44 2 49 11 2414.5SULT1E1, GPT, UGT1A7, UGT1A10, UGT1A1, UGT1A4
38tamoxifen44 49 28 1113.5UGT1A4, UGT1A1, SULT1E1, GGT1, UGT1A3, SERPINB5
39flunitrazepam44 28 1112.5UGT1A3, UGT1A1, GUSB
40estradiol44 11 2412.5UGT1A5, UGT1A7, SCARB1, SULT1E1, UGT1A3, UGT1A4
41cholesterol44 28 11 2413.5LPXN, ABCB4, UGT1A1, GGT1, SCARB1, CCK
42glucose4410.4CCK, SCARB1, PSG2, LPXN, CCKAR
43dopamine44 28 11 2413.4GGT1, CCK, CCKAR
44phenobarbital44 28 1112.4GGT1, GUSB, UGT1A1, GPT
45intralipid4410.3CCK, CCKAR, SST
46retinoic acid44 2411.3SST, CCK, UGT1A10, UGT1A1, UGT1A4, UGT1A5
47testosterone44 59 11 2413.3SST, SULT1E1, GGT1, UGT1A7, UGT1A10, SERPINB5
48amine4410.2UGT1A3, UGT1A7, UGT1A1, UGT1A4
49buprenorphine44 28 1112.1GUSB, UGT1A3, UGT1A1
50lipid4410.1GGT1, CCKAR, SERPINB5, PSG2, GPT, LPXN

GO Terms for genes affiliated with Cholelithiasis

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16Gene Ontology
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Cellular components related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00578910.2UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4

Biological processes related to Cholelithiasis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1flavone metabolic processGO:05155210.6UGT1A7, UGT1A1, UGT1A10
2xenobiotic glucuronidationGO:05269710.6UGT1A1, UGT1A7, UGT1A3
3flavonoid glucuronidationGO:05269610.5UGT1A1, UGT1A7, UGT1A3
4cellular glucuronidationGO:05269510.5UGT1A10, UGT1A1, UGT1A4
5retinoic acid metabolic processGO:04257310.4UGT1A1, UGT1A7, UGT1A3
6xenobiotic metabolic processGO:00680510.4UGT1A4, UGT1A1, UGT1A5, GGT1, SULT1E1
7metabolic processGO:00815210.4UGT1A3, UGT1A10, UGT1A5
8estrogen metabolic processGO:00821010.4SULT1E1, UGT1A1
9digestionGO:00758610.2CCKAR, UGT1A1, SST
10small molecule metabolic processGO:04428110.1SCARB1, GUSB, UGT1A4, UGT1A1, GPT, ABCB4
11response to nutrientGO:00758410.0SST, UGT1A1, CCKAR

Molecular functions related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:01502010.3UGT1A3, UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A4
2retinoic acid bindingGO:00197210.2UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
3protein heterodimerization activityGO:04698210.2UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4
4enzyme bindingGO:01989910.1UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3
5protein homodimerization activityGO:0428039.9SCARB1, UGT1A4, UGT1A1, UGT1A10, UGT1A7, UGT1A3

Products for genes affiliated with Cholelithiasis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Cholelithiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet