MCID: CHL004
MIFTS: 47

Cholelithiasis malady

Gastrointestinal diseases category

Summaries for Cholelithiasis

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66Wikipedia, 34MalaCards
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Wikipedia:66 A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by... more...

MalaCards: Cholelithiasis is related to cholecystitis and choledocholithiasis. An important gene associated with Cholelithiasis is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Steroid hormone biosynthesis and Bile secretion. The drug ursodiol and the compounds Etiocholanolone glucuronide and Estrone glucuronide have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney.

Aliases & Classifications for Cholelithiasis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cholelithiasis 9 11 46 63


External Ids:

Disease Ontology9 DOID:10211
MeSH36 D002769
ICD9CM28 574.5

Related Diseases for Cholelithiasis

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18GeneCards, 19GeneDecks
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Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis31.1GPT, CCK
2choledocholithiasis30.8GUSB, GPT
3pancreatitis30.7ABCB4, SST, CCK
4sickle cell disease30.6GUSB, UGT1A1
5hepatitis30.5GUSB, GPT
6cholestasis30.5CCK, GPT, ABCB4
7liver cirrhosis30.4ABCB4, GPT, SST
8cholangitis30.3GPT, ABCB4
9obesity30.3CCK, SCARB1, GPT
10pancreatic cancer30.2CCK, SST, PSG2
11acute pancreatitis30.1CCK, SST, PSG2, GPT
12adenocarcinoma29.9CCK, SST, PSG2, GUSB, UGT1A1
13colorectal cancer29.8UGT1A1, GUSB, PSG2, CCK
14obstructive jaundice29.8GPT, PSG2, CCK
15insulin resistance29.7SST, SCARB1, GPT
16gallbladder disease 110.3
17liver disease10.3
18hiatus hernia10.2
19sickle cell anemia10.2
20thalassemia10.2
21crigler-najjar syndrome10.1UGT1A1
22ascariasis10.1
23hereditary spherocytosis10.1
24appendicitis10.1
25situs inversus10.1
26choledochal cyst10.1
27down syndrome10.1
28hyperparathyroidism10.1
29myotonic dystrophy10.1
30ileus10.1
31neonatal jaundice10.1UGT1A1, GUSB
32kernicterus10.1UGT1A5, UGT1A1
33pancreas disease10.1PSG2, CCK
34steatorrhea10.1CCK, SST
35gastrointestinal system disease10.1CCK, PSG2
36glucagonoma10.1SST, CCK
37short bowel syndrome10.1SST, CCK
38bilirubin metabolic disorder10.1UGT1A1, UGT1A5
39duodenal ulcer10.1SST, CCK
40peptic ulcer disease10.0SST, CCK
41paraganglioma10.0PSG2, SST
42acromegaly10.0CCK, SST
43factor vii deficiency10.0UGT1A1, PSG2, SST
44primary sclerosing cholangitis10.0ABCB4, GPT
45intrahepatic cholestasis10.0
46gilbert syndrome10.0
47portal vein thrombosis10.0
48biliary dyskinesia10.0
49primary hyperparathyroidism10.0
50ascending cholangitis10.0

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to cholelithiasis

Symptoms for Cholelithiasis

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Drugs & Therapeutics for Cholelithiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cholelithiasis

Drug clinical trials:

Search ClinicalTrials for Cholelithiasis

Search NIH Clinical Center for Cholelithiasis

Search CenterWatch for Cholelithiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cholelithiasis

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Anatomical Context for Cholelithiasis

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34MalaCards
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MalaCards organs/tissues related to Cholelithiasis:

34
Liver, Heart, Kidney, Colon, Pancreas, Bone, Small intestine, B cells, Breast, Smooth muscle, Spinal cord, Bone marrow, Testes, Ovary, Prostate

Animal Models for Cholelithiasis or affiliated genes

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Publications for Cholelithiasis

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Sources:
53PubMed
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Articles related to Cholelithiasis:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Cumulative exposure to ritonavir-boosted atazanavir is associated with cholelithiasis in patients with HIV-1 infection. (24379301)
2013
2
Cholelithiasis in obese adolescents treated at an outpatient clinic. (24361296)
2013
3
Prevalence of cholelithiasis in Buenos Aires, Argentina. (23940909)
2013
4
Study on Salmonella Typhi occurrence in gallbladder of patients suffering from chronic cholelithiasis-a predisposing factor for carcinoma of gallbladder. (23790418)
2013
5
Miniinvasive surgical management of cholelithiasis for elderly and senile patients: a retrospective study. (23863204)
2013
6
Effect of genetic variants related to lipid metabolism as risk factors for cholelithiasis after bariatric surgery in Brazilian population. (22271356)
2012
7
Does the routine echocardiographic exam have a role in the detection and evaluation of cholelithiasis and gallbladder wall thickening? (22747757)
2012
8
CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. (21628634)
2011
9
Laparoscopic removal of a double gallbladder for cholelithiasis: a case report. (21929901)
2011
10
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
11
Cholelithiasis in a neonate with chylous ascites. (20182428)
2010
12
Laparoscopic cholecystectomy for cholelithiasis in a patient with myotonic dystrophy. (19660233)
2009
13
Study of Helicobacter hepaticus in gallbladders with cholelithiasis and its sensitivity pattern. (20071844)
2009
14
Cholelithiasis in thalassemia major. (19021734)
2009
15
Cholelithiasis and cholecystitis. (19726705)
2009
16
Comment on: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence? (Eur J Pediatr 2008;167(1):109-110). (18670788)
2009
17
Perioperative management of cholelithiasis in patients presenting for laparoscopic Roux-en-Y gastric bypass: have we reached a consensus? (19545094)
2009
18
Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder. (18440760)
2008
19
Ectopic partial intrahepatic gall bladder with cholelithiasis--a rare anomaly. (18298024)
2007
20
Laparoscopic management of appendicitis and symptomatic cholelithiasis during pregnancy. (16909295)
2006
21
Clinicopathological study of cholelithiasis following gastric cancer surgery. (15818039)
2005
22
Chronic cholelithiasis with gallstones lodged in an isolated subserosal intramural gastric pouch. (15892397)
2005
23
Gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis. (16304871)
2005
24
Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease. (16044312)
2005
25
Mechanisms of acute cholelithiasis. (12631454)
2003
26
Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. (12902918)
2003
27
Combined needlescopic cholecystectomy and laparoscopic splenectomy for the treatment of thalassaemic splenomegaly and cholelithiasis. (14750388)
2003
28
Delay of diagnosis in pancreatic cancer due to suspected symptomatic cholelithiasis. (12523594)
2002
29
Cholelithiasis and Gilbert's syndrome in homozygous beta-thalassaemia. (11843828)
2001
30
Tract microflora in Saudi patients with cholelithiasis. (11469952)
2001
31
Cholecystectomy versus cholecystolithotomy for cholelithiasis in childhood: long-term outcome. (11584400)
2001
32
Imaging of cholelithiasis: what does the surgeon need? (11116351)
2001
33
Case 2. Cholelithiasis of the liver. (10367663)
1999
34
Similarity in gallstone formation from 900 kcal/day diets containing 16 g vs 30 g of daily fat: evidence that fat restriction is not the main culprit of cholelithiasis during rapid weight reduction. (9539651)
1998
35
Rim sign. Radionuclide imaging in a patient with acute gangrenous cholecystitis and cholelithiasis after nonspecific abdominal ultrasonography. (9193810)
1997
36
Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. (8677945)
1996
37
Risk of pancreatic cancer associated with cholelithiasis, cholecystectomy, or gastrectomy. (8654135)
1996
38
Cholelithiasis in children with sickle cell disease. (24057785)
1996
39
Clinical analysis of choledochoduodenal fistula with cholelithiasis in Taiwan: assessment by endoscopic retrograde cholangiopancreatography. (8561111)
1996
40
ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. (7795450)
1995
41
Incidental diagnosis of asymptomatic neonatal cholelithiasis: case report and literature review. (8558341)
1995
42
Re: "Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.)". (7653477)
1995
43
Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis. (8577230)
1995
44
Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.) (7817971)
1995
45
Low levels of hepatic cytochrome P-450 in Mexicans with uncomplicated cholelithiasis. (7839018)
1994
46
Laparoscopic cholecystectomy in complicated cholelithiasis. (7809805)
1994
47
The changing pattern of cholelithiasis in Accra. (7756184)
1994
48
The bacteriology of cholelithiasis--China versus Japan. (1787607)
1991
49
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)
1982
50
Cholelithiasis and hiatus hernia. (86699)
1979

Variations for Cholelithiasis

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Expression for genes affiliated with Cholelithiasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for genes affiliated with Cholelithiasis

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
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Pathways related to Cholelithiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.6UGT1A5, UGT1A1
29.5SCARB1, ABCB4
3
Show member pathways
9.3UGT1A1, UGT1A5, ABCB4
4
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.2UGT1A5, GUSB, UGT1A1
5
Show member pathways
9.2GUSB, UGT1A1, UGT1A5
6
Show member pathways
7.4UGT1A5, UGT1A1, GPT, GUSB, SCARB1, ABCB4

Compounds for genes affiliated with Cholelithiasis

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25HMDB, 46Novoseek
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Compounds related to Cholelithiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1Etiocholanolone glucuronide259.7UGT1A1, GUSB, UGT1A5
2Estrone glucuronide259.7UGT1A5, UGT1A1, GUSB
3Estriol-3-glucuronide259.7UGT1A5, UGT1A1, GUSB
4Glycochenodeoxycholic acid 3-glucuronide259.7GUSB, UGT1A1, UGT1A5
5Inodxyl glucuronide259.7GUSB, UGT1A1, UGT1A5
6Isovalerylglucuronide259.7GUSB, UGT1A1, UGT1A5
7Estriol-17-glucuronide259.7UGT1A5, GUSB, UGT1A1
8Cortolone-3-glucuronide259.7UGT1A1, UGT1A5, GUSB
9Cotinineglucuronide259.6GUSB, UGT1A1, UGT1A5
10Dehydroepiandrosterone 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
11Dehydroisoandrosterone 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
12Deoxycholic acid 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
13Ketoprofen glucuronide259.6GUSB, UGT1A1, UGT1A5
14Thyroxine glucuronide259.6UGT1A1, UGT1A5, GUSB
15trans-3-Hydroxycotinine glucuronide259.6GUSB, UGT1A1, UGT1A5
16Triiodothyronine glucuronide259.6GUSB, UGT1A1, UGT1A5
17Tyramine glucuronide259.6GUSB, UGT1A1, UGT1A5
18Valproic acid glucuronide259.6GUSB, UGT1A1, UGT1A5
19Vitamin D2 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
20Tetrahydroaldosterone-3-glucuronide259.6UGT1A5, GUSB, UGT1A1
21Lithocholate 3-O-glucuronide259.6GUSB, UGT1A1, UGT1A5
22Nicotine glucuronide259.6GUSB, UGT1A1, UGT1A5
23Octanoylglucuronide259.6GUSB, UGT1A1, UGT1A5
24Testosterone glucuronide259.6GUSB, UGT1A1, UGT1A5
25bilirubin diglucuronide46 2510.6GUSB, UGT1A1, UGT1A5
2611-Oxo-androsterone glucuronide259.6UGT1A1, UGT1A5, GUSB
2715-hydroxynorandrostene-3,17-dione glucuronide259.6GUSB, UGT1A1, UGT1A5
2816-alpha,17-beta-estriol 17-beta-D-glucuronide259.6GUSB, UGT1A1, UGT1A5
292-Methoxy-estradiol-17b 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
302-Methoxyestrone 3-glucuronide259.6GUSB, UGT1A1, UGT1A5
312-Phenylethanol glucuronide259.5GUSB, UGT1A1, UGT1A5
3211-Hydroxyprogesterone 11-glucuronide259.5UGT1A5, GUSB, UGT1A1
33(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)259.5GUSB, UGT1A1, UGT1A5
341-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid259.5GUSB, UGT1A1, UGT1A5
351-Salicylate glucuronide259.5GUSB, UGT1A1, UGT1A5
3611-beta-hydroxyandrosterone-3-glucuronide259.5GUSB, UGT1A1, UGT1A5
3725-Hydroxyvitamin D2 25-(beta-glucuronide)259.5GUSB, UGT1A1, UGT1A5
384-Hydroxyandrostenedione glucuronide259.5UGT1A1, UGT1A5, GUSB
39Benzoyl glucuronide (Benzoic acid)259.4GUSB, UGT1A1, UGT1A5
40Bilirubin glucuronide259.4GUSB, UGT1A1, UGT1A5
41Cholestane-3,7,12,25-tetrol-3-glucuronide259.4GUSB, UGT1A1, UGT1A5
42Cholesterol glucuronide259.4GUSB, UGT1A1, UGT1A5
43glycocholate469.3GUSB, GPT, ABCB4
44Cholic acid glucuronide259.3GUSB, UGT1A1, UGT1A5
45lactulose469.3CCK, GUSB, GPT
463-Methoxy-4-hydroxyphenylglycol glucuronide259.3UGT1A5, GUSB, UGT1A1
4725-Hydroxyvitamin D2-25-glucuronide259.2GUSB, UGT1A1, UGT1A5
483-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide259.2GUSB, UGT1A1, UGT1A5
493,17-Androstanediol glucuronide259.1GUSB, UGT1A1, UGT1A5
503-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide258.9GUSB, UGT1A1, UGT1A5

GO Terms for genes affiliated with Cholelithiasis

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17Gene Ontology
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Biological processes related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:0075849.6UGT1A1, SST
2digestionGO:0075869.3UGT1A1, SST
3response to drugGO:0424939.2ABCB4, UGT1A1, SST
4small molecule metabolic processGO:0442818.0ABCB4, UGT1A1, GPT, GUSB, SCARB1

Molecular functions related to Cholelithiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:0150209.6UGT1A1, UGT1A5

Products for genes affiliated with Cholelithiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholelithiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet