MCID: CHL004
MIFTS: 47

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 35 574.5
SNOMED-CT 64 197397004 266475002
ICD10 33 K80
UMLS 69 C0006739

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to thalassemia-beta, dominant inclusion-body and gallbladder disease 1. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Benzocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and pancreas, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 72 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
id Related Disease Score Top Affiliating Genes
1 thalassemia-beta, dominant inclusion-body 31.4 HBB UGT1A1 UGT1A6
2 gallbladder disease 1 11.7
3 dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema 11.0
4 cholestasis, benign recurrent intrahepatic, 2 10.7 ABCB4 NR1H4
5 spherocytosis, type 2 10.7
6 dehydrated hereditary stomatocytosis 2 10.7
7 cholecystolithiasis 10.7
8 gallbladder disease 4 10.7
9 clonorchiasis 10.7
10 pancreatic neuroendocrine tumor 10.7
11 duodenal atresia 10.7
12 overhydrated hereditary stomatocytosis 10.7
13 erythrocytosis due to bisphosphoglycerate mutase deficiency 10.7
14 spherocytosis, type 1 10.7
15 cholestasis, benign recurrent intrahepatic 10.6 ABCB4 NR1H4
16 anhidrosis 10.6 ABCB4 CCK
17 familial osteochondritis dissecans 10.6 ALB APOE
18 tjp2-related familial hypercholanemia 10.6 HBB UGT1A1
19 skull base meningioma 10.6 APOE SST
20 perianal hematoma 10.5 CCK SST
21 intussusception 10.5 ALB CCK
22 chronic inflammatory demyelinating polyneuritis 10.5 ALB HBB
23 adie pupil 10.5 ALB SST
24 hyperbilirubinemia, familial transient neonatal 10.5 UGT1A1 UGT1A6
25 punctate epithelial keratoconjunctivitis 10.4 UGT1A1 UGT1A6
26 female infertility of uterine origin 10.4 ALB GPT
27 pancreatic cystadenocarcinoma 10.4 ALB GPT
28 trigonocephaly with short stature and developmental delay 10.4 ALB SST
29 bile duct cystadenocarcinoma 10.4 CCK SST
30 prostate cancer, progression and metastasis of 10.4 ABCB4 ALB NR1H4
31 chronic rheumatic pericarditis 10.4 ABCB4 ALB NR1H4
32 nodular degeneration of cornea 10.4 HBB UGT1A1
33 angelucci's syndrome 10.4 ALB SST
34 iris mixed cell melanoma 10.3 CCK SST
35 cholecystitis 10.3
36 isthmus cancer 10.3 ABCB4 ALB GPT
37 atrophic vulva 10.3 ALB CCK
38 patent foramen ovale 10.2 ALB GPT NR1H4
39 bladder cancer, childhood 10.2 APOE SST
40 renal artery disease 10.2 ALB UGT1A1 UGT1A6
41 choledocholithiasis 10.2
42 bubonic plague 10.2 ALB GPT SST
43 tonsil cancer 10.1 ALB GPT
44 malignant fibrous histiocytoma of bone 10.1 APOE CYP7A1 NR1H4
45 pancreatitis 10.1
46 kohler's disease 10.1 ABCB4 ALB GPT UGT1A1
47 mandibular cancer 10.1 CCK CCKAR SST
48 acute hydrops keratoconus 10.0 UGT1A1 UGT1A6
49 campylobacteriosis 10.0 ABCB4 CYP7A1 GPT
50 cryoglobulinemia 10.0 CCK CCKAR SST

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.81 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
2 homeostasis/metabolism MP:0005376 9.7 ABCB4 ABCG5 ABCG8 ALB APOE CCK
3 liver/biliary system MP:0005370 9.28 CYP7A1 NR1H4 SCARB1 ABCB4 ABCG5 ABCG8

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
10
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
15
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2 128-13-2 31401
16
Ondansetron Approved Phase 4 99614-02-5 4595
17
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
18
Levobupivacaine Approved Phase 4 27262-47-1 92253
19
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
20
Ephedrine Approved Phase 4 299-42-3 9294
21
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
22
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
23
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
24
Morphine Approved, Investigational Phase 4 57-27-2 5288826
25
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
26
Pseudoephedrine Approved Phase 4 90-82-4 7028
27
Etomidate Approved Phase 4 33125-97-2 36339 667484
28
Meperidine Approved Phase 4 57-42-1 4058
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
31
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
32
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
33
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
34
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
35
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
36
Sulbactam Approved Phase 4 68373-14-8
37 tannic acid Approved, Nutraceutical Phase 4
38 Nefopam Investigational Phase 4 13669-70-0
39 Sultamicillin Investigational Phase 4 76497-13-7
40 Analgesics Phase 4
41 Analgesics, Opioid Phase 4
42 Anesthetics Phase 4,Phase 1,Phase 2
43 Anesthetics, General Phase 4
44 Anesthetics, Intravenous Phase 4
45 Central Nervous System Depressants Phase 4,Phase 1
46 Hypnotics and Sedatives Phase 4,Phase 1
47 Narcotics Phase 4
48 Peripheral Nervous System Agents Phase 4,Phase 1
49 Adjuvants, Anesthesia Phase 4
50 Anesthetics, Dissociative Phase 4

Interventional clinical trials:

(show top 50) (show all 253)

id Name Status NCT ID Phase Drugs
1 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
2 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
3 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
4 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
6 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
7 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
8 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
9 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
10 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
11 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
12 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
13 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
14 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
15 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
16 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
17 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
18 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
19 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
20 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
21 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
22 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
23 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
24 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
25 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
26 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4 Tauroursodeoxycholic acid
27 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Recruiting NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
28 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
29 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Recruiting NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
30 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Enrolling by invitation NCT03168555 Phase 4 chenodeoxycholic acid
31 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
32 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
33 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
34 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
35 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
36 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
37 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
38 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
39 Indications for Gallbladder Surgery in Gallstone Disease Completed NCT01190280 Phase 3
40 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
41 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
42 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
43 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
44 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
45 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
46 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
47 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
48 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Recruiting NCT02490111 Phase 3 DWJ1319;Placebo
49 Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy Recruiting NCT02595086 Phase 3
50 Pentoxifylline Treatment in Acute Pancreatitis (AP) Enrolling by invitation NCT02487225 Phase 3 Pentoxifylline;Placebo

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

id Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

39
Liver, Skin, Pancreas, Bone, Heart, Colon, Kidney

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 660)
id Title Authors Year
1
Cholelithiasis and its complications in sickle cell disease in a university hospital. ( 28270342 )
2017
2
Pre- and Post-operative Comparative Analysis of Serum Lipid Profile in Patients with Cholelithiasis. ( 28904919 )
2017
3
Is Concomitant Cholecystectomy Necessary for Asymptomatic Cholelithiasis During Laparoscopic Sleeve Gastrectomy? ( 28803397 )
2017
4
Cholelithiasis in adult bearded dragons: retrospective study of nine adult bearded dragons (Pogona vitticeps) with cholelithiasis between 2013 and 2015 in southern Germany. ( 28627055 )
2017
5
Cholelithiasis. ( 28745992 )
2017
6
Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease? ( 28567595 )
2017
7
Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. ( 28244632 )
2017
8
Cholecystoduodenal fistula, an infrequent complication of cholelithiasis: Our experience in its surgical management. ( 28389051 )
2017
9
Intrahepatic cholelithiasis in dogs and cats: A case series. ( 28878422 )
2017
10
Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. ( 28383429 )
2017
11
Laparoscopic cholecystectomy for cholelithiasis in children with sickle cell disease. ( 28555355 )
2017
12
Cholelithiasis in a Patient With History of Cholecystectomy. ( 28870658 )
2017
13
Cholelithiasis - always infected? ( 28703118 )
2017
14
Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study. ( 28353587 )
2017
15
Miniinvasive surgical interventions in management of cholelithiasis A retrospective study. ( 28604381 )
2017
16
Physical Chemistry of Bile: Detailed Pathogenesis of Cholelithiasis. ( 28350710 )
2017
17
Single Stage Management of Concomitant Cholelithiasis and Choledocholithiasis. ( 28598447 )
2017
18
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
19
Cholecystolithotomy Combined Armillarisin A versus Cholecystectomy in Cirrhotic Portal Hypertension Patients with Symptomatic Cholelithiasis. ( 28463673 )
2017
20
Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy - A Case Report and Review of the Literature. ( 28210714 )
2017
21
Endoscopic management of choledocholithiasis and cholelithiasis in patients with cirrhosis. ( 26799755 )
2016
22
To leave no stone unturned: cholelithiasis and subsequent gallstone ileus. ( 27154989 )
2016
23
Cholelithiasis and complicated chronic pancreatitis mimicking malignancy. ( 26882896 )
2016
24
Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient. ( 27746433 )
2016
25
Prevalence and characteristics of clinically significant retained common bile duct stones after laparoscopic cholecystectomy for symptomatic cholelithiasis. ( 27847796 )
2016
26
COMMENT: HOSPITALIZATIONS FOR CHOLECYSTITIS AND CHOLELITHIASIS IN THE STATE OF RIO GRANDE DO SUL, BRAZILREPLY. ( 28076493 )
2016
27
COMPARATIVE ANALYSIS OF PREOPERATIVE ULTRASONOGRAPHY REPORTS WITH INTRAOPERATIVE SURGICAL FINDINGS IN CHOLELITHIASIS. ( 27120735 )
2016
28
Effect of emodin on mobility signal transduction system of gallbladder smooth muscle in Guinea pig with cholelithiasis. ( 27794381 )
2016
29
Spontaneous Cholelithiasis in a Squirrel Monkey (Saimiri sciureus). ( 26884412 )
2016
30
UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children. ( 27981643 )
2016
31
Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population. ( 27995261 )
2016
32
Acute pain management in symptomatic cholelithiasis. ( 27830044 )
2016
33
Cholelithiasis in Patients with Gaucher Disease type 1: Risk Factors and the Role of ABCG5/ABCG8 Gene Variants. ( 27981300 )
2016
34
Risk Factors for Cholelithiasis. ( 27467059 )
2016
35
Neonatal Bartter syndrome with cholelithiasis and hydrocephalus: Rare association. ( 27682612 )
2016
36
The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study. ( 27063855 )
2016
37
Risk factors, complications and outcome of cholelithiasis in children: A retrospective, single-centre review. ( 27236017 )
2016
38
Focal gall bladder polyarteritis nodosa in a case of cholelithiasis. ( 27728677 )
2016
39
Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid. ( 28089591 )
2016
40
Corrigendum to "The incidence of cholelithiasis after sleeve gastrectomy and its association with weight loss: A two-centre retrospective cohort study" [Int. J. Surg. 30 (2016) 13-18]. ( 27693476 )
2016
41
Elective cholecystectomy reduces morbidity of cholelithiasis in pediatric sickle cell disease. ( 27643455 )
2016
42
Pregnane receptor gene polymorphisms, pathogenic bacteria distribution and drug sensitivity, and TCM syndrome differentiation in patients with cholelithiasis. ( 27086146 )
2016
43
Prevalence of Cholelithiasis and Choledocholithiasis in Morbidly Obese South Indian Patients and the Further Development of Biliary Calculus Disease After Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass. ( 26910024 )
2016
44
Choledocholithiasis Without Cholelithiasis: Should the Gallbladder Stay or Should It Go? ( 26738738 )
2016
45
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
46
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. ( 27033116 )
2016
47
Comment on "The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia". ( 26813445 )
2016
48
Frequency of Cholelithiasis and Biliary Pathology in the Easter Island Rapanui and Non-Rapanui Populations. ( 27039794 )
2016
49
Possible Atazanavir-Induced Cholelithiasis in a Pregnant Woman: A Case Report. ( 27621492 )
2016
50
Severe acute hemorrhagic pancreatitis secondary to cholelithiasis as a rare cause of sudden unexpected death in medico-legal case: A case report. ( 27559973 )
2016

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 ABCB4 ABCG5 ABCG8 ALB APOE CYP7A1
2
Show member pathways
12.34 ABCG5 ABCG8 ALB APOE SCARB1
3 12.26 APOE HBB UGT1A1 UGT1A6
4
Show member pathways
11.69 ALB APOE HBB SCARB1
5
Show member pathways
11.46 CYP7A1 UGT1A1 UGT1A6
6
Show member pathways
11.28 ABCG5 ABCG8 SCARB1
7 11.25 ABCG5 ABCG8 SCARB1
8
Show member pathways
11.19 ABCG5 ABCG8 APOE CYP7A1 SCARB1
9 11 ABCB4 ABCG5 CYP7A1 NR1H4
10 10.95 ABCB4 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1
11 10.74 CYP7A1 NR1H4
12 10.71 ABCB4 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.96 APOE HBB
2 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG5 ABCG8

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 ABCB4 ABCG5 ABCG8 SST UGT1A1
2 lipid transport GO:0006869 9.8 ABCB4 APOE SCARB1
3 receptor-mediated endocytosis GO:0006898 9.8 ALB APOE HBB SCARB1
4 steroid metabolic process GO:0008202 9.78 APOE CYP7A1 UGT1A1
5 cellular oxidant detoxification GO:0098869 9.7 ALB APOE HBB
6 digestion GO:0007586 9.69 CCKAR SST UGT1A1
7 drug transmembrane transport GO:0006855 9.63 ABCB4 ABCG5
8 reverse cholesterol transport GO:0043691 9.62 APOE SCARB1
9 positive regulation of nitric-oxide synthase activity GO:0051000 9.61 APOE SCARB1
10 intestinal absorption GO:0050892 9.6 ABCB4 SCARB1
11 cellular glucuronidation GO:0052695 9.59 UGT1A1 UGT1A6
12 fatty acid homeostasis GO:0055089 9.58 APOE NR1H4
13 intestinal cholesterol absorption GO:0030299 9.57 ABCG5 ABCG8
14 high-density lipoprotein particle clearance GO:0034384 9.56 APOE SCARB1
15 xenobiotic glucuronidation GO:0052697 9.55 UGT1A1 UGT1A6
16 response to nutrient GO:0007584 9.55 ABCG5 ABCG8 CCKAR SST UGT1A1
17 triglyceride homeostasis GO:0070328 9.54 APOE NR1H4 SCARB1
18 high-density lipoprotein particle remodeling GO:0034375 9.5 ALB APOE SCARB1
19 regulation of bile acid biosynthetic process GO:0070857 9.48 CYP7A1 NR1H4
20 negative regulation of intestinal cholesterol absorption GO:0045796 9.43 ABCG5 ABCG8
21 cholesterol catabolic process GO:0006707 9.43 APOE CYP7A1 SCARB1
22 negative regulation of intestinal phytosterol absorption GO:0010949 9.4 ABCG5 ABCG8
23 regulation of cholesterol metabolic process GO:0090181 9.27 NR1H4
24 cholesterol efflux GO:0033344 9.26 ABCG5 ABCG8 APOE SCARB1
25 flavonoid glucuronidation GO:0052696 9.24 UGT1A1
26 cholesterol homeostasis GO:0042632 9.02 ABCG5 ABCG8 APOE CYP7A1 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.32 UGT1A1 UGT1A6
2 antioxidant activity GO:0016209 9.26 ALB APOE
3 retinoic acid binding GO:0001972 9.16 UGT1A1 UGT1A6
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB4 ABCG5 ABCG8
5 cholesterol transporter activity GO:0017127 8.8 ABCG5 ABCG8 APOE

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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