Cholestasis malady

Wikipedia: In medicine, cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two...⁴⁴ more...

MalaCards: Cholestasis, also known as obstruction of bile duct nos (disorder), is related to intrahepatic cholestasis of pregnancy and intrahepatic cholestasis. An important gene associated with Cholestasis is ATP8B1 (ATPase, aminophospholipid transporter, class I, type 8B, member 1), and among its related pathways are ABC transporters and Methotrexate Pathway, Pharmacokinetics. The compounds daunorubicin and Conjugated Estrogens have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and thyroid, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Descriptions:

cholestasis 6 7 8 32 43 obstruction of bile duct nos (disorder) 6 obstruction of bile duct (disorder) 6 occlusion of bile duct (disorder) 6 obstruction of bile duct 6

cardiovascular occlusion 43 bile duct obstruction 32 cholestasis (finding) 6 bile occlusion 6 obstruction 43

Diseases related to cholestasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1077)

id	Related Disease	Score	Top Affiliating Genes
1	intrahepatic cholestasis of pregnancy	40.3	BCL2, BAX, LAP3, CES1, ATP8B1, IL2RA
2	intrahepatic cholestasis	40.0	SCT, ATP8B1, JAG1, ALPP, HLA-G, NR1H2
3	chronic obstructive pulmonary disease	38.7	SERPINA1, MPO, IL6, F2RL1, TNF, CYP1A1
4	benign recurrent intrahepatic cholestasis	36.0	LIPC, LCAT, CETP, ATP8B1, ABCB11, GGT3P
5	obstructive jaundice	35.9	LCAT, CCK, GPT, ALPP, TTR, SLC17A5
6	cholestasis, progressive familial intrahepatic 1	35.7	ATP8B1, JAG1, NR1H4, ABCB11, ABCB4, SLC10A2
7	neonatal intrahepatic cholestasis caused by citrin deficiency	34.6	GPT, F2, SLC17A5, SLC25A13
8	sleep apnea	34.3	PCNA, RBP4, LPL, IL6, APOA1, APOE
9	citrin deficiency	34.3	ASS1, GPT, F2, SLC17A5, SLC25A13
10	apnea	34.3	PCNA, RBP4, LPL, BCHE, BAX, IL6
11	pulmonary disease	34.2	PCNA, RBP4, SERPINC1, SERPINA1, VEGFA, LPL
12	extrahepatic cholestasis	33.6	ALPP, ABCC1, ABCC2, ABCC3, GGT1
13	hepatitis	33.1	RBP4, SERPINA1, SEPSECS, IL2RB, GPT, IFNA2
14	cholestasis, progressive familial intrahepatic 3	33.1	ATP8B1, JAG1, ABCB11, ABCB4
15	obstructive lung disease	32.9	SERPINA1, ALB, CALCA, TNF, ACE, SLPI
16	bronchitis	32.9	ANPEP, CYP1A1, PPARA, SHBG, TGFB2, TAC1
17	duodenal ulcer	31.0	SCT, MPO, CD14, IL2RB, IL6, CCK
18	alpha 1-antitrypsin deficiency	30.6	SERPINC1, SERPINA1, SEPSECS, VEGFA, MPO, CD14
19	alagille syndrome	30.5	LCAT, ATP8B1, JAG1, APOA1, ALB, NOTCH2
20	primary biliary cirrhosis	30.5	SEPSECS, BGLAP, SCT, CETP, IL2RB, GPT
21	jaundice	30.3	BLVRA, SCT, CIRH1A, LCAT, LAP3, CEACAM3
22	arc syndrome	30.3	VPS33B, LAMP1, CEACAM5, DPP4
23	abcb11-related intrahepatic cholestasis	30.2	AVP, NR3C2, CRH, DNAH8, POMC
24	copd	30.0	SERPINA1, VEGFA, BGLAP, BCL2, BAX, AVP
25	gastric ulcer	29.6	PCNA, VEGFA, MPO, IL6, IGF1, ALB
26	hepatitis c	29.6	SERPINA1, LIPC, GPT, IFNA2, F2, HLA-DRB1
27	biliary atresia	29.4	RBP4, VIL1, VEGFA, ATP8B1, JAG1, CD14
28	asthma	29.1	CNR1, PCNA, SERPINA1, VEGFA, LIFR, BGLAP
29	bronchial asthma	28.9	VEGFA, BGLAP, CEACAM3, MPO, CD14, IL2RA
30	bronchiectasis	28.8	SERPINA1, MPO, CD14, ITGAV, IL6, ALB
31	angioedema	28.6	SERPINC1, SERPINA1, LCAT, CETP, IL6, IFNA2
32	choledocholithiasis	28.6	GPT, ALB, ALPP, ABCB4, SLC17A5, GGT1
33	hypertrophic cardiomyopathy	28.6	ITGAV, ITGB6, IL6, APEH, IGF1, ALB
34	cholelithiasis	28.3	APOA1, APOE, ANPEP, CCK, GPT, F2
35	allergic asthma	28.2	PCNA, BCL2, CD14, CD160, IL2RA, IL2RB
36	emphysema	28.2	PCNA, SERPINA1, VEGFA, BGLAP, BAX, MPO
37	retinol binding protein	28.1	RBP4, MYC, LIPC, MKI67, APOA1, ALB
38	iron overload	28.1	RBP4, BCS1L, GPT, F5, F2, ALB
39	pulmonary function	28.0	SERPINA1, CEACAM3, MPO, CD14, IL6, GPT
40	pulmonary embolism	27.8	SERPINC1, MPO, FGA, IFNA2, F5, F3
41	liver cirrhosis	27.7	CNR1, GCG, RBP4, SERPINC1, SERPINA1, SEPSECS
42	pulmonary emphysema	27.7	PCNA, SERPINA1, VEGFA, BAX, ITGB6, CYP2A6
43	retinal vein occlusion	27.6	SERPINC1, VEGFA, IL6, F5, F3, F2
44	infertility	27.6	SERPINA1, VEGFA, LIFR, CLU, BCL2, BAX
45	multiple sclerosis	27.5	CD14, IL2RA, APOE, HLA-B, HLA-DQA1, HLA-DQB1
46	recurrent respiratory papillomatosis	27.5	IFNA2, ESR1, HLA-DQA1, HLA-DQB1, HLA-DRB1, TP53
47	ileus	27.3	GCG, IL6, CCK, F2, CALCA, TNF
48	pulmonary hypertension	27.3	PCNA, SERPINC1, VEGFA, BAX, ASS1, FGA
49	influenza	27.3	RAB11A, BAX, LAMP1, CES1, MPO, GYPB
50	respiratory failure	27.2	RBP4, SERPINC1, SERPINA1, BCHE, IL6, CCK

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cholestasis:

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MGI Mouse Phenotypes related to cholestasis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	FUT1, MNT, IL2RB, AQP8, DPP4, OPRK1
2	renal/urinary system phenotype	MP:0005367	10.2	CLU, BCL2, LCAT, BAX, AVP, JAG1
3	craniofacial phenotype	MP:0005382	10.1	NCOA6, LAMP1, JAG1, MNT, FBN1, ALPL
4	other phenotype	MP:0005395	10.0	CNR1, CLU, FBN1, APOE, ALPL, ESR2
5	respiratory system phenotype	MP:0005388	9.9	LPL, CD14, FBN1, APOE, ALPL, CALCA
6	hematopoietic system phenotype	MP:0005397	9.9	PCNA, BCL2, JAG1, ITGB6, FBN1, CCND1
7	hearing/vestibular/ear phenotype	MP:0005377	9.8	RDX, MYC, BCL2, BAX, ATP8B1, JAG1
8	embryogenesis phenotype	MP:0005380	9.6	NCOA6, SERPINC1, MYC, LIFR, MNT, ITGAV
9	no phenotypic analysis	MP:0003012	9.1	CNR1, PCNA, VEGFA, MYC, JAG1, MNT
10	digestive/alimentary phenotype	MP:0005381	9.0	NCOA6, GCG, VEGFA, MYC, BCL2, JAG1
11	integument phenotype	MP:0010771	8.8	NCOA6, CNR1, MYC, BCL2, LAMP1, MNT
12	normal phenotype	MP:0002873	8.7	RBP4, VIL1, VEGFA, MYC, LAMP1, AVP
13	nervous system phenotype	MP:0003631	8.6	NCOA6, CNR1, RDX, SERPINC1, MYC, LIFR
14	mortality/aging	MP:0010768	8.4	NCOA6, CNR1, GCG, SERPINC1, VEGFA, LPL
15	vision/eye phenotype	MP:0005391	8.3	NCOA6, RBP4, SERPINC1, VEGFA, BCL2, LCAT
16	reproductive system phenotype	MP:0005389	8.3	NCOA6, RBP4, VEGFA, LIPC, BCHE, FUT1
17	behavior/neurological phenotype	MP:0005386	8.1	CNR1, RDX, SCT, AVP, JAG1, MNT
18	skeleton phenotype	MP:0005390	8.0	CNR1, VEGFA, MYC, LIFR, BAX, LAMP1
19	muscle phenotype	MP:0005369	7.6	NCOA6, RBP4, VEGFA, LPL, MYC, CLU
20	adipose tissue phenotype	MP:0005375	7.3	CNR1, LPL, MYC, BCL2, CD14, IL6
21	tumorigenesis	MP:0002006	7.1	MYC, BCL2, MNT, ITGAV, IL6, CCND1
22	growth/size phenotype	MP:0005378	7.0	NCOA6, CNR1, GCG, LPL, MYC, LIFR
23	cardiovascular system phenotype	MP:0005385	INF	NCOA6, RBP4, SERPINC1, VEGFA, LPL, MYC
24	cellular phenotype	MP:0005384	INF	NCOA6, CNR1, PCNA, RBP4, VEGFA, MYC
25	immune system phenotype	MP:0005387	INF	CLU, ITGAV, IL6, FBN1, , ANPEP
26	homeostasis/metabolism phenotype	MP:0005376	INF	NCOA6, CNR1, RDX, GCG, RBP4, SERPINC1
27	liver/biliary system phenotype	MP:0005370	INF	NCOA6, RDX, SERPINC1, VEGFA, LPL, LCAT

Articles related to cholestasis:

(show top 50)    (show all 302)

id	Title	Authors	Year	Affiliating Genes
1	Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations. (21119540)	Colombo C.... Maggiore G.	2011	ABCB4
2	Heterozygous FIC1 deficiency: a new genetic predispos ition to transient neonatal cholestasis. (20216097)	Jacquemin E.... Bernard O.	2010	ATP8B1
3	The c.504T>C (p.Asn168Asn) polymorphism in the ABC B4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in G reece. (19840247)	Kitsiou-Tzeli S.... Tsezou A.	2010	ABCB4
4	Most common SLC25A13 mutation in 400 Chinese infants with intrahepatic cholestasis. (20458766)	Fu H.Y.... Wang J.S.	2010	SLC25A13
5	Is increased maternal endothelin-1 concentration asso ciated with neonatal asphyxia and preterm delivery in intrahepatic cholestasis of pregnancy? (19862540)	Kebapcilar A.G.... Gokulu S.G.	2010	EDN1, AHSG
6	Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human. (20147439)	Jemnitz K.... Vereczkey L.	2010	ABCB11
7	Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. (20422497)	Pauli-Magnus C.... Stieger B.	2010	NR1H4, ABCB4
8	Combined features of low phospholipid-associated chol elithiasis and progressive familial intrahepatic cholestasis 3. (19840255)	Poupon R.... Housset C.	2010	ABCB4
9	Folding defects in P-type ATP 8B1 associated with her editary cholestasis are ameliorated by 4-phenylbutyrate. (19918981)	van der Velden L.M.... van de Graaf S.F.	2010	ATP8B1
10	Calcineurin inhibitor-related cholestasis complicatin g lung transplantation. (20417810)	Oto T.... Miyoshi S.	2010	IL2RA, CABIN1
11	Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis. (19413638)	Aigelsreiter A.... Denk H.	2009	CLU
12	Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (19086036)	Yang H.... Lu S.C.	2009	TP53, MYC, CCND1
13	Effects of bezafibrate on dyslipidemia with cholestas is in children with familial intrahepatic cholestasis-1 deficiency manifesting progressive familial intrahepatic cholestasis. (19059530)	Nagasaka H.... Miida T.	2009	ABCB4
14	Differential effects of progressive familial intrahep atic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mu tations on canalicular localization of ATP8B1. (19731236)	Folmer D.E.... Paulusma C.C.	2009	ATP8B1
15	Intrahepatic cholestasis of pregnancy: when should you look further? (19266607)	Hardikar W.... Angus P.	2009	ABCB4
16	Neonatal intrahepatic cholestasis caused by citrin de ficiency: clinical and laboratory investigation of 13 subjects in mainland of C hina. (19185551)	Song Y.Z.... Zheng X.Y.	2009	SLC25A13, AFP
17	Identification and diagnosis of three novel mutations in SLC25A13 gene of neonatal intrahepatic cholestasis caused by citrin deficiency (19099775)	Song Y.Z.... Kobayashi K.	2008	SLC25A13
18	Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy. (18800312)	Owen B.M.... Dixon P.H.	2008	NR1I2
19	The polymorphism of HLA-DR and -DQ allelic genes associated with intrahepatic cholestasis of pregnancy. (18554163)	Ding Y.... Yang X.	2008	HLA-DQB1, HLA-DRB1
20	Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy (18575333)	Xu Z.... Xing A.Y.	2008	ATP8B1
21	Nutritional status of infants with neonatal cholestasis. (17717748)	Yuksekkaya H.A.... Aydogdu S.	2008	TTR
22	Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. (18706437)	Perez M.J.... Marin J.J.	2008	NR0B2, SLC23A1, SLC23A2
23	Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. (18176959)	Meier Y.... Pauli-Magnus C.	2008	ABCB11, ABCC2
24	Analysis of tear enzymes in the diagnosis of obstruc tive jaundice associated with subhepatic cholestasis (19143075)	Terekhina N.A.... Soldatenko N.V.	2008	GGT1
25	Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis. (17631146)	Marzioni M.... Benedetti A.	2007	GLP1R, GCG
26	Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene. (16891356)	Wasmuth H.E.... Lammert F.	2007	ABCB4
27	Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis. (17241866)	Liu C.... Bezerra J.A.	2007	JAG1, ABCB11, ABCB4
28	Prognosis, with evaluation of general biochemistry, of liver disease in lymphoedema cholestasis syndrome 1 (LCS1/Aagenaes syndrome). (16635916)	Drivdal M.... Aagenaes O.	2006	GGT1, ALPP
29	Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy (16762184)	Zhang L.... Xing A.Y.	2006	ESR1
30	Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations. (16696816)	Floreani A.... Mazzella G.	2006	ABCB4
31	The relationship between P53 and hypoxia-inducible transcription factor-1alpha in the placenta of patient with intrahepatic cholestasis of pregnancy under acute hypoxic condition (17236590)	Hu Y.Y.... Liu S.Y.	2006	TP53, HIF1A
32	Effects of oral and transdermal estradiol administration on levels of sex hormone-binding globulin in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy. (15784702)	Ropponen A.... Ylikorkala O.	2005	SHBG
33	Childhood cholestasis and bile transporters (16137474)	Hierro L.... Jara P.	2005	ATP8B1
34	Characterization of mutations in ATP8B1 associated with hereditary cholestasis. (15239083)	Klomp L.W.... Bull L.N.	2004	ATP8B1
35	Molecular basis of intrahepatic cholestasis. (15768832)	Carlton V.E.... Bull L.N.	2004	JAG1, TJP2, CIRH1A
36	Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1. (15317749)	Alvarez L.... Lapunzina P.	2004	NR1H4, NR0B2
37	Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. (15077010)	Pauli-Magnus C.... Kullak-Ublick G.A.	2004	ABCB11, ABCB4
38	The cannabinoid agonist WIN 55, 212-2 increases nocic eption threshold in cholestatic rats: implications for the treatment of the pru ritus of cholestasis. (13679241)	Gingold A.R.... Bergasa N.V.	2003	CNR1
39	Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. (12825874)	Eloranta M.L.... Heinonen S.	2003	ABCB11
40	Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. (14535985)	Milkiewicz P.... Elias E.	2003	GGT1, GPT, ABCB4
41	A novel inborn error of metabolism detected by elevated methionine and/or galactose in newborn screening: neonatal intrahepatic cholestasis caused by citrin deficiency. (12692712)	Ohura T.... Iinuma K.	2003	SLC25A13
42	Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: low GGT cholestasis is a clinical continuum. (11867191)	van Ooteghem N.A.... Houwen R.H.	2002	GGT3P
43	The bile acid synthetic gene 3beta-hydroxy-delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. (11067870)	Schwarz M.... Russell D.W.	2000	HSD3B7
44	Cholesteryl ester transfer activity in liver disease and cholestasis, and its relation with fatty acid composition of lipoprotein lipids. (8740580)	Iglesias A.... LasunciA^n M.A.	1996	CETP
45	Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region. (7655458)	Carlton V.E.... Freimer N.B.	1995	ATP8B1
46	Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. (7894490)	Houwen R.H.... Freimer N.B.	1994	ATP8B1
47	Paraneoplastic cholestasis and hypercoagulability associated with medullary thyroid carcinoma. Resolution with tumor debulking. (8299093)	Tiede D.J.... Hay I.D.	1994	CALCA
48	Endogenous digitalis-like factor in liver cirrhosis and cholestasis (7483706)	Behrens R.... Nilius R.	1993	ALB
49	Intrahepatic cholestasis in pregnancy. The hepatologist's point of view (8228018)	Bacq Y.	1993	F2, GPT
50	Hepatic changes and serum ferritin in pancreatic cancer and other gastrointestinal diseases: the role of cholestasis. (2024931)	Basso D.... Naccarato R.	1991	BCHE, TTR

Genes related to cholestasis according to GeneCards:

(show top 50)    (show all 209)

id	Symbol	Description	Score	GeneCards Section Context
1	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	11.1	Aliases & Descriptions, Summaries, Publications
2	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	11.1	Aliases & Descriptions, Publications
3	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	11.1	Summaries, Publications
4	CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)	11.0	Publications, Summaries
5	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog	11.0	Disorders, Summaries, Publications
6	LCS1	lymphedema-cholestasis syndrome 1	11.0	Aliases & Descriptions, Publications
7	ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	11.0	Publications
8	GGT1	gamma-glutamyltransferase 1	11.0	Publications
9	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	11.0	Publications
10	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0	Publications
11	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
12	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
13	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	11.0	Publications
14	GGT3P	gamma-glutamyltransferase 3 pseudogene	11.0	Publications
15	SLC25A13	solute carrier family 25 (aspartate/glutamate carrier), member 13	11.0	Publications
16	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	11.0	Publications
17	NR1I2	nuclear receptor subfamily 1, group I, member 2	11.0	Publications
18	F2	coagulation factor II (thrombin)	11.0	Publications
19	SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)	11.0	Publications
20	LAP3	leucine aminopeptidase 3	11.0	Publications
21	VPS33B	vacuolar protein sorting 33 homolog B (yeast)	11.0	Publications
22	JAG1	jagged 1	11.0	Publications
23	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
24	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	11.0	Publications
25	SLCO1B3	solute carrier organic anion transporter family, member 1B3	11.0	Publications
26	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
27	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
28	SLCO1B1	solute carrier organic anion transporter family, member 1B1	11.0	Publications
29	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
30	ALPP	alkaline phosphatase, placental	11.0	Publications
31	LIPC	lipase, hepatic	11.0	Publications
32	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
33	ABCD4	ATP-binding cassette, sub-family D (ALD), member 4	11.0	Publications
34	VIL1	villin 1	11.0
35	CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	11.0	Publications
36	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
37	HLA-E	major histocompatibility complex, class I, E	11.0	Publications
38	FABP6	fatty acid binding protein 6, ileal	11.0	Publications
39	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
40	SLCO1A2	solute carrier organic anion transporter family, member 1A2	11.0	Publications
41	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
42	CES1	carboxylesterase 1	11.0	Publications
43	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
44	EPAS1	endothelial PAS domain protein 1	11.0	Publications
45	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0	Publications
46	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
47	AFP	alpha-fetoprotein	11.0	Publications
48	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
49	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
50	TGFB2	transforming growth factor, beta 2	11.0	Publications

Pathways related to cholestasis according to GeneDecks:

(show top 50)    (show all 79)

id	Pathway	Score	Top Affiliating Genes
1	ABC transporters20	11.4	ABCB7, ABCB6, ABCB11, ABCB1, ABCC1, ABCC4
2	Methotrexate Pathway, Pharmacokinetics34	11.3	SLCO1B1, SLC22A6, SLCO1A2, SLC22A8, ABCG2, ABCC3
3	Pravastatin Pathway, Pharmacokinetics34	11.2	ABCG2, SLC22A8, SLC22A6, SLCO1B3, SLCO1B1, ABCC2
4	Metabolism of lipids and lipoproteins38	11.2	SLC10A2, AKR1D1, ALB, HSD3B7, CYP7A1, CYP8B1
5	Taxane Pathway, Pharmacokinetics34	11.2	ABCG2, CYP3A4, SLCO1B3, ABCC2, ABCC1, ABCB1
6	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	11.1	SLC22A6, SLC22A8, ABCG2, ABCC4, ABCC3, ABCC2
7	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics34	11.1	ABCG2, SLC22A2, ABCC4, SLC22A3, ABCC1, ABCB1
8	Methotrexate Pathway (Brain Cell), Pharmacokinetics34	11.1	SLCO1A2, ABCC1, ABCC4, ABCG2, SLC22A8, SLC22A6
9	Codeine and Morphine Pathway, Pharmacokinetics34	11.1	CYP3A4, CYP2D7P1, ABCB1, ABCC2, ABCC3, SLCO1B1
10	Graft-versus-host disease20	11.1	HLA-G, HLA-DQA1, HLA-DPA1, HLA-B, HLA-E
11	Mycophenolic acid Pathway, Pharmacokinetics34	11.1	SLCO1B3, CES1, CYP3A4, CYP3A5, ABCB1, ABCC2
12	Vinka Alkaloid Pathway, Pharmacokinetics34	11.1	ABCC3, ABCC2, CYP3A4, BAX, BCL2, CYP3A5
13	Statin Pathway - Generalized, Pharmacokinetics34	11.0	SLC22A8, ABCG2, ABCC2, ABCB11, ABCB1, CYP3A5
14	Irinotecan Pathway, Pharmacokinetics34	11.0	BCHE, CES1, CYP3A5, ABCB1, ABCC1, ABCC2
15	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	11.0	CYP3A4, MPO, ABCC3, ABCB1, ABCC1, NR1I2
16	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	11.0	ABCC2, CYP3A5, UGT1A3, SLCO1B1, SLCO1B3, ABCB1
17	Primary bile acid biosynthesis20	11.0	CYP8B1, CYP7A1, CYP7B1, CYP27A1, AMACR, HSD3B7
18	CTL Mediated Apoptosis36	10.9	HLA-B, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-G, HLA-E
19	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics34	10.9	ABCC4, SLC22A6, SLC22A8, ABCG2
20	Steroid hormone biosynthesis20	10.8	CYP7B1, CYP3A5, CYP1A1, UGT1A3, HSD11B2, AKR1D1
21	Irinotecan Pathway, Pharmacodynamics34	10.8	BCHE, ABCG2, ABCC2, UGT1A3, ABCB1, CES1
22	Carbamazepine Pathway, Pharmacokinetics34	10.7	CYP2B6, NR1I3, NR1I2, CYP3A5, ABCC2, CYP3A4
23	Autoimmune thyroid disease20	10.7	HLA-E, HLA-DQA1, HLA-DPA1, HLA-DQB1, HLA-G, HLA-B
24	Gefitinib Pathway, Pharmacokinetics34	10.7	CYP3A5, CYP2C19, CYP3A4, CYP1A1, ABCB1, ABCG2
25	Erlotinib Pathway, Pharmacokinetics34	10.7	CYP3A4, CYP1A1, ABCG2, ABCB1, CYP3A5
26	Fluvastatin Pathway, Pharmacokinetics34	10.6	CYP3A4, CYP3A5, SLCO1B3, CYP2C19, UGT1A3, SLCO1B1
27	Allograft rejection20	10.6	HLA-B, HLA-E, HLA-DRB1, HLA-G, TNF, HLA-DQB1
28	Clopidogrel Pathway, Pharmacokinetics34	10.5	CYP2C19, CYP2B6, CES1, CYP3A4, CYP3A5, ABCB1
29	Phagosome20	10.5	LAMP1, MPO, CD14, ITGAV, HLA-B, HLA-DPA1
30	Immune response IL-22 signaling pathway10	10.5	HLA-DPA1, IL2RB, HLA-DQA1, HLA-DQB1, HLA-DRB1, STAT3
31	Type I diabetes mellitus20	10.5	HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-E, HLA-G
32	Immune response_IL-22 signaling pathway41	10.5	STAT3, MYC, HLA-DRB1, BCL2, IL2RA, IL2RB
33	Colorectal cancer20	10.4	SMAD2, TGFB2
34	Metabolic pathways20	10.4	CYP2B6, GGT1, CYP2C19, CYP2A6, CYP3A43, CYP1A1
35	Retinol metabolism10	10.4	CYP2B6, CYP2C19, CYP3A5, CYP2A6, CYP3A4, CYP1B1
36	Retinol metabolism41	10.4	CYP3A5, CYP2C19, CYP2B6, CYP2A6, UGT1A3, CYP1B1
37	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics34	10.3	ABCG2, CYP3A5, CYP2C19, CYP3A4
38	Biological oxidations38	10.3	CYP2B6, CYP2A6, CYP3A43, CYP3A4, CYP3A5, CYP2J2
39	Cyclophosphamide Pathway, Pharmacokinetics34	10.2	CYP2C19, CYP3A4, CYP2A6, CYP2B6, CYP3A5
40	Bile secretion20	10.2	SLC22A1, SLCO1B1, NR0B2, NR1H4, RXRA, ABCB1
41	Retinol metabolism20	9.7	CYP2A6, CYP3A43, CYP3A4, CYP1A1, UGT1A3, CYP2B6
42	Tuberculosis20	9.5	IFNA2, LAMP1, IL6, HLA-DPA1, HLA-DQA1, HLA-DQB1
43	Pathways in cancer20	9.3	ITGAV, STAT3, EPAS1, MYC, BCL2, BAX
44	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.2	TNF, BGLAP, IL6, APOE, CYP3A4, RXRA
45	JAK-STAT Pathway36	9.2	SOCS3, IL2RB, IL2RA, FGF19, BCL2, LIFR
46	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	APOE, IL6, TNF, CYP3A4, RXRA, IGF1
47	IL-10 Pathway36	9.0	STAT3, SOCS3, CD14, MYC, TNF, CCND1
48	PPAR signaling pathway20	INF	RXRA, LPL, , PPARA, CYP27A1, CYP8B1
49	Statin Pathway, Pharmacodynamics34	INF	APOE, LPL, , CYP7A1, ABCB1, LIPC
50	Selected targets of HNF110	INF	SLCO1B1, SLC4A2, DPP4, NR1I2, NR1H4, HNF1B

Compounds related to cholestasis according to GeneDecks:

(show top 50)    (show all 685)

id	Compound	Score	Top Affiliating Genes
1	daunorubicin32 9 9	12.9	MYC, BCL2, BAX, MPO, CYP1A1, CYP1B1
2	Conjugated Estrogens9 9	11.8	ESR1, CYP3A4, ABCB1, ABCC1, ABCC2, ABCC3
3	rifampicin32	10.8	GPT, HNF4A, CYP7A1, CYP1A1, CYP3A4, CYP2A6
4	Taurocholic Acid9 18 9	12.7	FABP6, CYP7A1, ABCB1, ABCB11, ABCC1, ABCC2
5	rifampin34 9 9	12.5	CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19, CYP3A5
6	cimetidine32 9 9	12.5	SCT, HLA-B, CYP3A4, CYP2A6, CYP2C19, CYP3A5
7	glucose32	10.4	GCG, SCT, LAP3, AVP, MKI67, IFNA2
8	lovastatin32 42 9 9	13.3	LPL, LIPC, BCHE, CETP, CES1, APOE
9	quercetin32 42 9 18 9	14.3	BCL2, UGT1A3, BAX, CCND1, F3, ALPP
10	cocaine32 9 9	12.2	CNR1, GCG, BCHE, CES1, CCK, GPT
11	irinotecan32 34 9 9	13.1	VEGFA, BAX, CEACAM5, CEACAM3, CES1, MKI67
12	chloramphenicol32 9 9	12.1	SERPINC1, LPL, MYC, CETP, MPO, ALPP
13	calcitriol32 42 9 18 9	13.9	MYC, CLU, BGLAP, CD14, IL2RA, ALB
14	doxorubicin32 34 9 9	12.9	CLU, CEACAM5, CEACAM3, MKI67, IL2RA, CCND1
15	Heme9 18 9	11.8	BLVRA, MPO, ALB, CYP7A1, CYP1A1, CYP1B1
16	fluorescein32 9 9	11.8	SERPINC1, VEGFA, BGLAP, ATP8A1, MPO, IL2RA
17	oxygen32 18	10.7	RBP4, SERPINA1, LIPC, BLVRA, CLU, BCHE
18	5fluorouracil32	9.7	PCNA, GCG, VEGFA, BCL2, BAX, CEACAM5
19	heparin32 9 18 9	12.6	GCG, SERPINA1, LPL, LIPC, BGLAP, BCHE
20	estradiol32 9 18 9	12.5	PCNA, UGT1A3, CEACAM5, MKI67, CCND1, HSD11B2
21	estrone32 9 18 9	12.5	LPL, BGLAP, UGT1A3, IL2RA, IGF1, ALB
22	digoxin32 42 34 9 18 9	14.5	F2, CYP3A4, NR1I2, ABCB1, ABCB11, ABCC1
23	glutamate32	9.4	CNR1, PCNA, GCG, CLU, BCHE, LCAT
24	zidovudine32 9 9	11.4	LPL, MYC, GPT, IFNA2, F3, ALB
25	glycerol32 9 18 9	12.3	PCNA, GCG, SERPINC1, LPL, LIPC, ATP8A1
26	calcium32 9 18 9	12.2	CNR1, RDX, RBP4, VIL1, LIPC, BGLAP
27	folate32	9.2	RBP4, SERPINC1, MYC, CLU, MKI67, IL2RA
28	retinoid32	9.1	RBP4, MYC, BCL2, BAX, CD14, IL2RB
29	histamine32 18	10.1	CNR1, PCNA, GCG, BGLAP, SCT, MPO
30	butyrate32	8.8	PCNA, GCG, MYC, CLU, BCHE, BCL2
31	estrone sulfate32 18	9.8	BGLAP, CCK, IGF1, ALB, ESR1, CYP1B1
32	paclitaxel32 34 9 9	11.7	PCNA, VEGFA, MYC, LIFR, CLU, BCL2
33	cyclosporin a32 42	9.7	PCNA, SEPSECS, LPL, MYC, LIPC, BGLAP
34	paraffin32	8.3	PCNA, SERPINA1, VEGFA, MYC, CLU, BGLAP
35	cisplatin32 34 9 9	11.2	PCNA, VEGFA, MYC, CLU, BGLAP, BCHE
36	ezetimibe32 9 9	INF	UGT1A3, CETP, CES1, , ANPEP, GPT
37	pge232	INF	SCT, CD14, , CCK, F2R, F2RL1
38	aspirin32 34 18	INF	CNR1, PCNA, SERPINC1, BCHE, CETP, FGA
39	uric acid32 18	INF	RBP4, AVP, , GPT, F5, ALB
40	acetylcholine32 9 18 9	INF	CNR1, GCG, LPL, BCHE, SCT, MPO
41	retinoic acid32 42 18	INF	NCOA6, PCNA, RBP4, MYC, CLU, BGLAP
42	fibrinogen32	INF	SERPINC1, SERPINA1, LIPC, CLU, CEACAM3, CD14
43	tacrolimus32 34 9 9	INF	PCNA, MYC, IL2RA, IL2RB, , CCND1
44	lipid32	INF	CNR1, RDX, GCG, RBP4, SERPINA1, LPL
45	sterol32	INF	LIPC, LCAT, CETP, CES1, , APOE
46	cholesterol32 9 18 9	INF	RBP4, SERPINA1, LPL, LIFR, LIPC, CLU
47	genistein32 9 18 9	INF	PCNA, GCG, VEGFA, LPL, MYC, BCL2
48	metformin32 34 9 9	INF	CNR1, GCG, LPL, , GPT, IGF1
49	estrogen32	INF	NCOA6, RDX, PCNA, GCG, RBP4, SERPINC1
50	dexamethasone32 42 34 9 9	INF	PCNA, RBP4, SERPINC1, VEGFA, LPL, MYC

Cellular components related to cholestasis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.9	HLA-G, HLA-E, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
2	ER to Golgi transport vesicle membrane	GO:012507	10.8	HLA-G, HLA-E, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
3	basolateral plasma membrane	GO:016323	10.4	SLC23A2, SLCO1B1, SLC10A1, SLCO1B3, SLC4A2, SLC22A6
4	integral to plasma membrane	GO:005887	10.2	SLC22A1, OPRK1, OPRD1, ABCC3, ABCC2, ABCC1
5	membrane	GO:016020	9.9	SLC22A1, ABCC4, ABCC3, ABCC1, ABCB4, ABCB11
6	platelet alpha granule lumen	GO:031093	9.4	TGFB2, ALB, F5, IGF1, FGA, CLU
7	endoplasmic reticulum membrane	GO:005789	9.3	CYP7B1, CYP4X1, CYP17A1, CYP3A5, CYP2J2, NR3C2
8	nucleoplasm	GO:005654	8.9	SMAD2, NR3C2, NR1I3, NR1I2, SMAD7, NOTCH2
9	plasma membrane	GO:005886	INF	OPRD1, SLC23A2, SLC23A1, GGT1, GGT2, SLC22A2
10	extracellular space	GO:005615	INF	GCG, RBP4, SERPINC1, SERPINA1, VEGFA, LPL
11	extracellular region	GO:005576	INF	SHBG, NOTCH2, CRH, ESR2, CALCA, ALB
12	high-density lipoprotein particle	GO:034364	INF	, CETP, LCAT, LIPC, APOE

Biological processes related to cholestasis according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	bile acid metabolic process	GO:008206	11.3	ATP8B1, SLC10A1, SLCO1B1, SLC10A2, SLCO1B3, FABP6
2	organic anion transport	GO:015711	11.2	SLCO1B1, SLC10A1, SLC10A2, SLCO1B3, SLC22A6, SLCO1A2
3	interferon-gamma-mediated signaling pathway	GO:060333	11.1	SOCS3, HLA-G, HLA-E, HLA-DRB1, HLA-DQB1, HLA-DQA1
4	bile acid biosynthetic process	GO:006699	11.1	ABCB11, CYP27A1, CYP7B1, CYP8B1, CYP7A1, AKR1D1
5	very-low-density lipoprotein particle remodeling	GO:034372	11.0	APOE, CETP, LCAT, LIPC, LPL
6	drug transmembrane transport	GO:006855	10.8	SLC22A2, SLC22A3, SLC22A1, ABCG2, ABCB1
7	sodium-independent organic anion transport	GO:043252	10.7	SLCO1B1, SLCO4A1, SLCO1B3, SLCO1C1, SLC22A6, SLCO1A2
8	xenobiotic metabolic process	GO:006805	10.6	CYP7B1, CYP17A1, CYP27A1, CYP3A5, CYP2J2, NR1I2
9	release of cytochrome c from mitochondria	GO:001836	10.6	TP53, CCK, BAX, BCL2, CLU, MYC
10	response to glucose stimulus	GO:009749	10.5	ADIPOQ, HIF1A, SMAD2, NR1H4, NR0B2, HNF4A
11	exogenous drug catabolic process	GO:042738	10.5	NR1I2, CYP2C19, CYP2B6, CYP2A6, CYP3A4
12	transcription initiation from RNA polymerase II promoter	GO:006367	10.4	NR1I2, NR1I3, NR3C2, SMAD2, SMAD7, NOTCH2
13	oxidation-reduction process	GO:055114	10.4	G6PD, CYP2C19, CYP2B6, CYP3A4, CYP1B1, CYP1A1
14	transport	GO:006810	10.3	ABCC3, ABCG2, TTR, SLC51A, SLC10A2, SLC10A1
15	organ regeneration	GO:031100	10.2	AFP, SOCS3, AHSG, NR0B2, CCND1, MKI67
16	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.2	ADIPOQ, NR1H2, PPARA, ITGAV, CETP
17	cytokine-mediated signaling pathway	GO:019221	10.2	HLA-DRB1, HLA-E, HLA-G, STAT3, SOCS3, HLA-DQB1
18	response to lipopolysaccharide	GO:032496	10.1	SOCS3, TAC1, EDN1, NR1H4, ALPL, F2R
19	response to estradiol stimulus	GO:032355	10.1	SOCS3, STAT3, TGFB2, CTNNB1, ESR1, F3
20	steroid metabolic process	GO:008202	10.1	CYP3A5, CYP17A1, CYP2C19, CYP2B6, CYP2A6, CYP3A4
21	acute-phase response	GO:006953	9.9	STAT3, AHSG, F2, IL6, ASS1, SERPINA1
22	positive regulation of cell migration	GO:030335	9.9	ABCC1, EDN1, ONECUT1, F2RL1, F2R, F3
23	cell surface receptor signaling pathway	GO:007166	9.7	PRLR, EDN1, TNFRSF10B, CABIN1, F2, IFNA2
24	bile acid and bile salt transport	GO:015721	9.7	ATP8B1, FABP6, ALB, ABCB11, ABCC3, SLC51A
25	response to ethanol	GO:045471	9.6	ADIPOQ, STAT3, RXRA, GOT2, CCND1, AVP
26	response to hypoxia	GO:001666	9.4	TGFB2, DPP4, SOCS3, ADIPOQ, EPAS1, HIF1A
27	response to glucocorticoid stimulus	GO:051384	9.4	TNF, RXRA, ABCB4, SOCS3, ADIPOQ, HSD11B2
28	response to drug	GO:042493	9.3	CTNNB1, EDN1, ABCB1, ABCB4, ABCC1, ABCG2
29	positive regulation of cell proliferation	GO:008284	9.0	F2, F2R, GLP1R, EDN1, TGFB2, DPP4
30	negative regulation of apoptotic process	GO:043066	8.8	GLP1R, HNF1B, TP53, TNF, TGFB2, PRKAA2
31	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	SMAD2, NR1H4, NR1H2, PPARA, CTNNB1, SMAD7
32	cholesterol metabolic process	GO:008203	INF	RXRA, NR0B2, CYP27A1, CYP7B1, APOE,
33	lipoprotein metabolic process	GO:042157	INF	PPARA, ALB, APOE, , CETP, LCAT
34	triglyceride homeostasis	GO:070328	INF	HNF4A, , CETP, LIPC, LPL
35	high-density lipoprotein particle remodeling	GO:034375	INF	APOE, , CETP, LCAT, LIPC
36	cellular lipid metabolic process	GO:044255	INF	HADHA, PRKAA2, ABCB4, RXRA, NR1H2, PPARA
37	platelet activation	GO:030168	INF	F2, F2R, ALB, ABCC4, TGFB2, F5
38	platelet degranulation	GO:002576	INF	F5, ALB, ABCC4, TGFB2, IGF1,
39	transmembrane transport	GO:055085	INF	AVP, ABCG2, SLC22A1, SLC22A3, SLC22A8, SLCO1A2
40	lipid metabolic process	GO:006629	INF	HNF4A, CYP3A4, PPARA, ABCB4, G6PD, ALB
41	reverse cholesterol transport	GO:043691	INF	APOE, , CETP, LCAT, CLU, LIPC
42	small molecule metabolic process	GO:044281	INF	NCOA6, GLP1R, AKR1D1, CYP7A1, CYP1A1, CYP1B1
43	blood coagulation	GO:007596	INF	F2, F2R, F2RL1, ALB, HNF4A, TP53

Molecular functions related to cholestasis according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	organic anion transmembrane transporter activity	GO:008514	11.0	SLCO1B3, SLC22A6, SLCO1A2, SLC22A8, ABCC3, ABCC2
2	ATPase activity, coupled to transmembrane movement of substances	GO:042626	10.9	ABCG2, ABCD4, ABCC4, ABCC3, ABCC2, ABCC1
3	xenobiotic-transporting ATPase activity	GO:008559	10.8	ABCG2, ABCC1, ABCB4, ABCB1
4	steroid hormone receptor activity	GO:003707	10.6	RXRA, NR3C2, NR1I2, NR1H4, NR1H2, NR0B2
5	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.5	STAT3, RXRA, NR1I3, NR1I2, NR1H4, NR1H2
6	steroid binding	GO:005496	10.5	NR3C2, CYP3A4, ESR2, ESR1, AKR1D1, HSD11B2
7	aromatase activity	GO:070330	10.4	CYP2J2, CYP3A5, CYP4X1, CYP3A43, CYP1B1, CYP1A1
8	heme binding	GO:020037	10.4	MPO, ABCB6, CYP2J2, CYP3A5, CYP27A1, CYP17A1
9	iron ion binding	GO:005506	10.3	CYP7B1, CYP4X1, CYP17A1, CYP27A1, CYP3A5, CYP2J2
10	electron carrier activity	GO:009055	10.3	CYP7B1, CYP4X1, CYP17A1, CYP27A1, CYP3A5, CYP2J2
11	oxygen binding	GO:019825	10.3	CYP3A5, CYP17A1, CYP8B1, CYP2C19, CYP3A4, CYP1B1
12	monooxygenase activity	GO:004497	10.1	CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
13	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavopr	GO:016712	10.0	CYP2B6, CYP2A6, CYP3A4, CYP1B1
14	sequence-specific DNA binding	GO:043565	9.8	NR1I2, NR1I3, NR3C2, RXRA, NFE2L2, HIF1A
15	receptor binding	GO:005102	9.7	HNF4A, HLA-B, HLA-G, CRH, TGFB2, DPP4
16	hormone activity	GO:005179	9.6	HAMP, ADIPOQ, POMC, TTR, EDN1, CRH
17	protease binding	GO:002020	9.4	DPP4, TNF, TP53, F3, BCL2, SERPINA1
18	protein homodimerization activity	GO:042803	9.0	NR0B2, SHBG, ABCG2, G6PD, TGFB2, DPP4
19	protein heterodimerization activity	GO:046982	8.7	RXRA, HIF1A, TGFB2, SLC51A, SLC51B, EPAS1
20	protein binding	GO:005515	INF	NR1H2, NR1H4, NR1I2, NR3C2, SMAD2, SMAD7
21	enzyme binding	GO:019899	INF	CYP2A6, CYP2C19, CTNNB1, RXRA, ACIN1, HIF1A