MCID: CHL068
MIFTS: 59

Cholestasis malady

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Cholestasis

Aliases & Descriptions for Cholestasis:

Name: Cholestasis 12 29 52 42 14 69
Obstruction of Bile Duct 12
Bile Duct Obstruction 52
Bile Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13580
ICD10 33 K83.1
ICD9CM 35 576.2
MeSH 42 D002779
NCIt 47 C83006
UMLS 69 C0008370

Summaries for Cholestasis

MalaCards based summary : Cholestasis, also known as obstruction of bile duct, is related to cholestasis, benign recurrent intrahepatic, 2 and cholestasis, intrahepatic, of pregnancy, 1, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Metabolism and Synthesis of bile acids and bile salts. The drugs Ursodeoxycholic acid and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 71 Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic... more...

Related Diseases for Cholestasis

Diseases related to Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
id Related Disease Score Top Affiliating Genes
1 cholestasis, benign recurrent intrahepatic, 2 33.5 ABCB11 ABCB4 ATP8B1 NR1H4
2 cholestasis, intrahepatic, of pregnancy, 1 33.2 ABCB11 ABCB4 ATP8B1 GGT1 NR1H4 SLC10A2
3 gallbladder disease 1 31.7 ABCB11 ABCB4 ATP8B1
4 eclampsia 26.5 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP
5 intrahepatic cholestasis 12.4
6 cholestasis, benign recurrent intrahepatic 12.4
7 cholestasis, progressive familial intrahepatic 1 12.2
8 cholestasis-lymphedema syndrome 12.2
9 arthrogryposis, renal dysfunction, and cholestasis 1 12.2
10 cholestasis, progressive familial intrahepatic 3 12.1
11 cholestasis, intrahepatic, of pregnancy, 3 12.1
12 cholestasis, progressive familial intrahepatic 2 12.1
13 cholestasis, progressive familial intrahepatic 4 12.1
14 arthrogryposis, renal dysfunction, and cholestasis 2 12.0
15 cholestasis, progressive familial intrahepatic 5 12.0
16 extrahepatic cholestasis 12.0
17 low gamma-gt familial intrahepatic cholestasis 11.9
18 vipas39-related arthrogryposis, renal dysfunction, and cholestasis syndrome 11.7
19 vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome 11.7
20 cholestasis, familial intrahepatic, of pregnancy 1 11.7
21 cholestasis, familial intrahepatic, of pregnancy 3 11.7
22 alagille syndrome 11.7
23 citrullinemia, type ii, neonatal-onset 11.6
24 abcb11-related intrahepatic cholestasis 11.6
25 myo5b-related progressive familial intrahepatic cholestasis 11.6
26 atp8b1-related intrahepatic cholestasis 11.6
27 gracile syndrome 11.6
28 bile acid synthesis defect, congenital, 2 11.5
29 bile acid synthesis defect, congenital, 1 11.5
30 bile acid synthesis defect, congenital, 4 11.4
31 alagille syndrome 2 11.3
32 hardikar syndrome 11.1
33 biliary atresia 11.0
34 crigler-najjar syndrome, type ii 11.0
35 hyperbiliverdinemia 10.9
36 bile acid synthesis defect, congenital, 3 10.8
37 atp8b1 deficiency 10.7
38 congenital bile acid synthesis defect 10.7
39 amyloidosis, familial visceral 10.6
40 congenital bile acid synthesis defect 6 10.6
41 primary biliary cholangitis 10.6
42 nephronophthisis 19 10.6
43 interstitial lung and liver disease 10.6
44 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 10.6
45 biliary atresia, extrahepatic 10.6
46 gilbert syndrome 10.6
47 mitochondrial dna depletion syndrome 15, hepatocerebral type 10.6
48 citrullinemia, adult-onset type ii 10.6
49 cirrhosis, north american indian childhood type 10.6
50 hepatitis 10.5

Comorbidity relations with Cholestasis via Phenotypic Disease Network (PDN): (show all 17)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Biliary Tract Neoplasm
Cholangitis Cholecystitis
Deficiency Anemia Duodenum Cancer
Esophagitis Gallbladder Cancer
Gastrointestinal System Cancer Intrahepatic Gall Duct Cancer
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholestasis:



Diseases related to Cholestasis

Symptoms & Phenotypes for Cholestasis

UMLS symptoms related to Cholestasis:


icterus, jaundice (not of newborn)

MGI Mouse Phenotypes related to Cholestasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 ABCB11 ABCB4 ABCC4 ATP8B1 CYP7A1 GGT1
2 homeostasis/metabolism MP:0005376 10.03 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 integument MP:0010771 9.56 ABCC3 ABCC4 CYP7A1 GGT1 HSD3B7 NR1H4
4 liver/biliary system MP:0005370 9.4 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CYP7A1

Drugs & Therapeutics for Cholestasis

Drugs for Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 241)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
2
Abatacept Approved Phase 4 332348-12-6 10237
3
Sorbitol Approved Phase 4 50-70-4 5780
4
Choline Approved, Nutraceutical Phase 4 62-49-7 305
5
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
6 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
8 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
9 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Nootropic Agents Phase 4
12 Polyene phosphatidylcholine Phase 4
13 Bile Acids and Salts Phase 4,Phase 3,Phase 2,Phase 1
14 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
15 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
16 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 3,Phase 1
17 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
18 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 3,Phase 1
19 Cholagogues and Choleretics Phase 4,Phase 2,Phase 3,Phase 1
20 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
21 Immunosuppressive Agents Phase 4,Phase 3,Phase 1
22 Cathartics Phase 4,Phase 3,Phase 2
23 Laxatives Phase 4,Phase 3,Phase 2
24 Tocopherols Phase 4
25 Tocotrienols Phase 4
26 methionine Nutraceutical Phase 4,Phase 3,Phase 2
27 Lecithin Nutraceutical Phase 4
28 Olive Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
29 Soy Bean Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
30 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
31 Phytosterol Nutraceutical Phase 4
32 Coconut Nutraceutical Phase 4
33 Tocopherol Nutraceutical Phase 4
34 Tocotrienol Nutraceutical Phase 4
35
Ethanol Approved Phase 3 64-17-5 702
36
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
37
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
38
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
39
Trioxsalen Approved Phase 3,Phase 2 3902-71-4 5585
40
Bezafibrate Approved Phase 3 41859-67-0 39042
41
Copper Approved Phase 3 15158-11-9, 7440-50-8 27099
42
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
43
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
44
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
45
Colchicine Approved Phase 3 64-86-8 6167 2833
46
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
47
chenodeoxycholic acid Approved Phase 3,Phase 2 474-25-9 10133
48
Budesonide Approved Phase 3,Phase 1 51333-22-3 63006 5281004
49
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
50
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173

Interventional clinical trials:

(show top 50) (show all 281)
id Name Status NCT ID Phase
1 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4
2 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
5 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4
6 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4
7 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
8 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
9 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
10 Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population Completed NCT02539316 Phase 4
11 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
12 Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT Completed NCT03048318 Phase 4
13 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
14 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
15 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4
16 SMOFLipid in Intralipid Intolerant Recruiting NCT03054948 Phase 4
17 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4
18 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
19 Preventing Cholestasis Using SMOFLipid® Active, not recruiting NCT01585935 Phase 4
20 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
21 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
22 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4
23 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4
24 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
25 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Unknown status NCT00753441 Phase 2, Phase 3
26 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3
27 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3
28 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
29 Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption Completed NCT02200029 Phase 3
30 Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed NCT02663453 Phase 3
31 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
32 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3
33 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
34 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3
35 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3
36 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3
37 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3
38 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3
39 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3
40 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3
41 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3
42 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3
43 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3
44 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3
45 Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis Recruiting NCT01555957 Phase 3
46 Cholestasis Reversal: Efficacy of IV Fish Oil Recruiting NCT00910104 Phase 2, Phase 3
47 Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants Recruiting NCT02534077 Phase 3
48 Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD Recruiting NCT02357576 Phase 3
49 Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children Recruiting NCT01194063 Phase 3
50 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02823366 Phase 3

Search NIH Clinical Center for Cholestasis

Cochrane evidence based reviews: cholestasis

Genetic Tests for Cholestasis

Genetic tests related to Cholestasis:

id Genetic test Affiliating Genes
1 Cholestasis 29

Anatomical Context for Cholestasis

MalaCards organs/tissues related to Cholestasis:

39
Liver, Placenta, Testes, Kidney, Bone, Pituitary, Brain

Publications for Cholestasis

Articles related to Cholestasis:

(show top 50) (show all 1574)
id Title Authors Year
1
Ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy: Results in real-world conditions and factors predictive of response to treatment. ( 27825922 )
2017
2
Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy. ( 28233754 )
2017
3
Two cases of first onset intrahepatic cholestasis of pregnancy associated with moderate ovarian hyperstimulation syndrome after IVF treatment and review of the literature. ( 28319428 )
2017
4
Ursodeoxycholic Acid Ameliorates Intrahepatic Cholestasis Independent of Biliary Bicarbonate Secretion in Vil2(kd/kd) Mice. ( 28049946 )
2017
5
Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats. ( 27988401 )
2017
6
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. ( 28049044 )
2017
7
Prognostic roles of tetrahydroxy bile acids in infantile intrahepatic cholestasis. ( 28073941 )
2017
8
Chronic Pruritus in an 18-Month-Old Male Infant Due to Anicteric Cholestasis. ( 28082665 )
2017
9
CCBE1 Mutation causing Sclerosing Cholangitis - Expanding the Spectrum of Lymphedema-Cholestasis Syndrome. ( 28073151 )
2017
10
Protective Effects of Petroleum Ether Extracts of Herpetospermum caudigerum against I+-naphthylisothiocyanate-Induced Acute Cholestasis of Rats. ( 28065777 )
2017
11
Outcomes following partial external biliary diversion in patients with progressive familial intrahepatic cholestasis. ( 27916445 )
2017
12
Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection. ( 27891271 )
2016
13
Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis. ( 27065293 )
2016
14
Minimally Invasive Treatment of Mirizzi Syndrome, a Rare Cause of Cholestasis in Childhood. ( 27843664 )
2016
15
Recent advances in understanding and managing cholestasis. ( 27134744 )
2016
16
Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis. ( 26879107 )
2016
17
The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy. ( 27049609 )
2016
18
Increased PR Interval in Fetuses of Patients with Intrahepatic Cholestasis of Pregnancy. ( 26959834 )
2016
19
Liver transplantation and the management of progressive familial intrahepatic cholestasis in children. ( 27358773 )
2016
20
Elevation of gamma-glutamyl transferase in adult: Should we think about progressive familiar intrahepatic cholestasis? ( 26699824 )
2016
21
Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3. ( 27256251 )
2016
22
Interleukin 31 is involved in intrahepatic cholestasis of pregnancy. ( 27406853 )
2016
23
Neonatal Cholestasis as Initial Presentation of Portosystemic Shunt: A Case Report. ( 28003725 )
2016
24
A Novel Truncation Mutation in ATP8B1 Gene in Progressive Familial Intrahepatic Cholestasis. ( 28064265 )
2016
25
Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice. ( 27635189 )
2016
26
A Novel Mutation of ABCB4 in Progressive Familial Intrahepatic Cholestasis 3: Like Mother, Like Daughter. ( 26796082 )
2016
27
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. ( 27475677 )
2016
28
A Is ursodeoxycholic acid detrimental in obstructive cholestasis? A propos of a case of malignant biliary obstruction. ( 27049500 )
2016
29
Benign Recurrent Intrahepatic Cholestasis in a Young Adult. ( 27504332 )
2016
30
Role of Multidrug Resistance Protein 3 (MDR3) in Antifungal-Induced Cholestasis. ( 27112167 )
2016
31
The Effect of Fish Oil-Based Lipid Emulsion and Soybean Oil-Based Lipid Emulsion on Cholestasis Associated with Long-Term Parenteral Nutrition in Premature Infants. ( 27110237 )
2016
32
Role of AMP-activated protein kinase I+1 in 17I+-ethinylestradiol-induced cholestasis in rats. ( 27090119 )
2016
33
Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience. ( 27066450 )
2016
34
Sclerostin Expression in Bile Ducts of Patients with Chronic Cholestasis May Influence the Bone Disease in Primary Biliary Cirrhosis. ( 27019303 )
2016
35
Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome. ( 26829045 )
2016
36
Intestinal injury in the rat model of 17I+-ethynylestradiol-induced intrahepatic cholestasis. ( 27624611 )
2016
37
Early alterations of bile canaliculi dynamics and the ROCK/MLCK pathway are characteristics of drug-induced intrahepatic cholestasis. ( 27538918 )
2016
38
Role of inflammation in intrahepatic cholestasis of pregnancy. ( 26786878 )
2016
39
Cell-free DNA is higher and more fragmented in intrahepatic cholestasis of pregnancy. ( 27778350 )
2016
40
Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis. ( 27239116 )
2016
41
Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis. ( 27799961 )
2016
42
Intrahepatic cholestasis of pregnancy. ( 27103313 )
2016
43
Effect of intrahepatic cholestasis ofA pregnancy on maternal serum screeningA tests. ( 28009332 )
2016
44
A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy. ( 27494119 )
2016
45
Is ursodeoxycholic acid effective for intrahepatic cholestasis of pregnancy? ( 26817509 )
2016
46
The Interaction of PPARI+ and CYP7B1 with ERI+, I^ Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats. ( 27628953 )
2016
47
Alanine aminotransferase as a predictor of adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy. ( 27182252 )
2016
48
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. ( 26888176 )
2016
49
Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. ( 28027587 )
2016
50
Neonatal isolated ACTH deficiency (IAD): a potentially life-threatening but treatable cause of neonatal cholestasis. ( 27535729 )
2016

Variations for Cholestasis

Expression for Cholestasis

Search GEO for disease gene expression data for Cholestasis.

Pathways for Cholestasis

Pathways related to Cholestasis according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 ABCB11 ABCB4 ABCC3 ALPP CYP7A1 GGT1
2
Show member pathways
12.1 ABCB11 ABCC3 CYP7A1 HSD3B7 NR1H4 SLC10A1
3
Show member pathways
12.08 ABCC2 ABCC3 ABCC4 SLCO1B1
4 12 ABCC2 ABCC3 ABCC4 GGT1
5
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLC10A1 SLCO1B1
6
Show member pathways
11.73 NR1H4 NR1I2 NR1I3
7 11.71 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
8
Show member pathways
11.69 ABCB11 ABCC2 ABCC4 SLCO1B1
9
Show member pathways
11.66 ABCC2 ABCC3 ABCC4
10
Show member pathways
11.48 ABCC2 NR1I2 NR1I3
11 11.21 ABCC2 ABCC3 NR1I3
12 11.18 ABCC2 ABCC3 ABCC4
13
Show member pathways
11.05 ABCC2 ABCC3 SLCO1B1
14 11.03 ABCC2 ABCC3 ABCC4
15 11 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
16
Show member pathways
10.97 ABCC2 ABCC3 ABCC4 SLCO1B1
17 10.89 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
18 10.86 ABCC2 ABCC3 ABCC4
19 10.78 ABCC3 NR1I2
20 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
21 10.71 ABCC2 NR1I2
22 10.57 ABCC2 ABCC3

GO Terms for Cholestasis

Cellular components related to Cholestasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.67 ABCB4 ABCC2 ATP8B1 SLC10A2
2 integral component of plasma membrane GO:0005887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 basolateral plasma membrane GO:0016323 9.56 ABCC3 ABCC4 SLC10A1 SLCO1B1
4 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
5 HOPS complex GO:0030897 9.32 VIPAS39 VPS33B
6 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
7 membrane GO:0016020 10.31 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP
8 integral component of membrane GO:0016021 10.22 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

Biological processes related to Cholestasis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.92 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 steroid hormone mediated signaling pathway GO:0043401 9.7 NR1H4 NR1I2 NR1I3
3 intracellular receptor signaling pathway GO:0030522 9.65 NR1H4 NR1I2 NR1I3
4 bile acid biosynthetic process GO:0006699 9.58 ABCB11 CYP7A1 HSD3B7
5 organic anion transport GO:0015711 9.57 ABCC2 SLCO1B1
6 phospholipid translocation GO:0045332 9.56 ABCB4 ATP8B1
7 bile acid metabolic process GO:0008206 9.55 ATP8B1 NR1H4
8 thyroid hormone transport GO:0070327 9.54 ABCC2 SLCO1B1
9 xenobiotic transport GO:0042908 9.54 ABCB4 ABCC3 NR1I2
10 drug export GO:0046618 9.51 ABCB4 NR1I2
11 response to antineoplastic agent GO:0097327 9.49 ABCB4 ABCC2
12 regulation of bile acid biosynthetic process GO:0070857 9.46 CYP7A1 NR1H4
13 drug transmembrane transport GO:0006855 9.46 ABCB4 ABCC2 ABCC3 ATP8B1
14 canalicular bile acid transport GO:0015722 9.43 ABCB11 ABCC2
15 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.26 ABCB11 ABCC2 ABCC3 ABCC4
16 bile acid and bile salt transport GO:0015721 9.17 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1 SLC10A2
17 transport GO:0006810 10.03 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Molecular functions related to Cholestasis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.73 ABCB11 ABCC2 ABCC3 SLC25A13
2 ATPase activity GO:0016887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
3 steroid hormone receptor activity GO:0003707 9.63 NR1H4 NR1I2 NR1I3
4 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.54 NR1H4 NR1I2 NR1I3
5 organic anion transmembrane transporter activity GO:0008514 9.51 ABCC2 ABCC3
6 xenobiotic-transporting ATPase activity GO:0008559 9.49 ABCB4 ABCC3
7 bile acid transmembrane transporter activity GO:0015125 9.48 SLC10A1 SLCO1B1
8 bile acid:sodium symporter activity GO:0008508 9.4 SLC10A1 SLC10A2
9 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
10 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
11 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
12 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Cholestasis

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