MCID: CHL068
MIFTS: 60

Cholestasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Cholestasis

MalaCards integrated aliases for Cholestasis:

Name: Cholestasis 12 72 28 51 41 14 69
Obstruction of Bile Duct 12
Bile Duct Obstruction 51
Bile Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13580
ICD10 32 K83.1
ICD9CM 34 576.2
MeSH 41 D002779
NCIt 46 C83006
UMLS 69 C0008370

Summaries for Cholestasis

MalaCards based summary : Cholestasis, also known as obstruction of bile duct, is related to cholestasis, benign recurrent intrahepatic, 1 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including jaundice (not of newborn) and icterus. An important gene associated with Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Synthesis of bile acids and bile salts and NRF2 pathway. The drugs Ursodeoxycholic acid and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related phenotypes are Downregulation of NF-kappaB pathway after TNFalpha stimulation and growth/size/body region

Wikipedia : 72 Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic... more...

Related Diseases for Cholestasis

Diseases related to Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 cholestasis, benign recurrent intrahepatic, 1 34.4 ABCB11 ATP8B1
2 cholestasis, progressive familial intrahepatic, 2 34.3 ABCB11 ABCB4 ATP8B1
3 cholestasis, progressive familial intrahepatic, 3 34.0 ABCB11 ABCB4 ATP8B1 JAG1
4 cholestasis, progressive familial intrahepatic, 1 33.7 ABCB11 ABCB4 ATP8B1 GGT1 JAG1 NR1H4
5 arthrogryposis, renal dysfunction, and cholestasis 1 33.7 VIPAS39 VPS33B
6 alagille syndrome 1 33.4 ABCB4 ATP8B1 JAG1
7 bile acid synthesis defect, congenital, 1 33.3 HSD3B7 TJP2
8 extrahepatic cholestasis 32.6 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1
9 atp8b1 deficiency 32.4 ABCB11 ATP8B1 NR1H4
10 biliary atresia, extrahepatic 31.8 GGT1 JAG1
11 biliary atresia 31.6 JAG1 NR1H4 SLC10A1
12 intrahepatic cholestasis 31.4 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GGT1
13 primary biliary cirrhosis 30.6 ABCB11 ABCB4 ABCC2 ABCC3 ALPP GGT1
14 cholangitis 30.3 ABCB11 ABCB4 GGT1
15 sclerosing cholangitis 30.2 ABCB11 ABCB4 NR1I2
16 cholelithiasis 30.2 ABCB4 CYP7A1 NR1H4
17 dubin-johnson syndrome 30.0 ABCC2 ABCC3 ABCC4
18 cholangitis, primary sclerosing 30.0 ABCB4 GGT1 NR1I2
19 bilirubin metabolic disorder 29.8 ABCC2 GGT1 NR1I3
20 obstructive jaundice 29.8 ALPP GGT1 SLC25A13
21 xanthomatosis 29.7 CYP7A1 NR1H4 NR1I2
22 liver disease 29.6 ABCB11 ABCB4 ALPP ATP8B1 GGT1 HSD3B7
23 cerebrotendinous xanthomatosis 29.3 CYP7A1 NR1H4 NR1I2
24 gastrointestinal system disease 29.3 ABCB11 GGT1 NR1I2
25 cholestasis, intrahepatic, of pregnancy, 1 12.4
26 cholestasis, benign recurrent intrahepatic, 2 12.4
27 cholestasis-lymphedema syndrome 12.3
28 cholestasis, intrahepatic, of pregnancy 3 12.2
29 cholestasis, progressive familial intrahepatic, 4 12.2
30 cholestasis, progressive familial intrahepatic, 5 12.2
31 arthrogryposis, renal dysfunction, and cholestasis 2 12.2
32 citrullinemia, type ii, neonatal-onset 12.0
33 cholestasis with gallstone, ataxia, and visual disturbance 11.8
34 myo5b-related progressive familial intrahepatic cholestasis 11.8
35 bile acid synthesis defect, congenital, 2 11.7
36 gracile syndrome 11.7
37 bile acid synthesis defect, congenital, 4 11.6
38 alagille syndrome 2 11.4
39 gallbladder disease 1 11.3
40 hardikar syndrome 11.3
41 citrullinemia, type ii, adult-onset 11.2
42 crigler-najjar syndrome, type ii 11.1
43 hyperbiliverdinemia 11.0
44 bile acid synthesis defect, congenital, 3 10.9
45 sclerosing cholangitis, neonatal 10.9
46 congenital bile acid synthesis defect 10.8
47 amyloidosis, familial visceral 10.7
48 gilbert syndrome 10.7
49 lambert syndrome 10.7
50 north american indian childhood cirrhosis 10.7

Comorbidity relations with Cholestasis via Phenotypic Disease Network (PDN): (show all 17)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Biliary Tract Neoplasm
Cholangitis Cholecystitis
Deficiency Anemia Duodenum Cancer
Esophagitis Gallbladder Cancer
Gastrointestinal System Cancer Intrahepatic Gall Duct Cancer
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholestasis:



Diseases related to Cholestasis

Symptoms & Phenotypes for Cholestasis

UMLS symptoms related to Cholestasis:


jaundice (not of newborn), icterus

GenomeRNAi Phenotypes related to Cholestasis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Downregulation of NF-kappaB pathway after TNFalpha stimulation GR00199-A-2 8.8 UTP4 NR1H4 TJP2

MGI Mouse Phenotypes related to Cholestasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 CYP7A1 GGT1 HSD3B7 JAG1 NR1H4 NR1I3
2 homeostasis/metabolism MP:0005376 10.13 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 integument MP:0010771 9.81 ABCC3 ABCC4 CYP7A1 GGT1 HSD3B7 JAG1
4 liver/biliary system MP:0005370 9.73 ABCC2 ABCC3 ATP8B1 CYP7A1 HSD3B7 JAG1
5 mortality/aging MP:0010768 9.44 ABCB11 ABCC4 ATP8B1 CYP7A1 GGT1 HSD3B7

Drugs & Therapeutics for Cholestasis

Drugs for Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 254)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
2
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
3
Glycerol Approved, Investigational Phase 4 56-81-5 753
4
Abatacept Approved Phase 4 332348-12-6 10237
5
Sorbitol Approved Phase 4 50-70-4 5780
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7 Coconut Approved, Nutraceutical Phase 4
8 Tocopherol Approved, Investigational, Nutraceutical Phase 4
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
12 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
13 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Nootropic Agents Phase 4
16 Polyene phosphatidylcholine Phase 4
17 Bile Acids and Salts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
19 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
20 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 3,Phase 1
21 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
22 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 3,Phase 1
23 Cholagogues and Choleretics Phase 4,Phase 2,Phase 3,Phase 1
24 Protective Agents Phase 4,Phase 2,Phase 1
25 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
26 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
27 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Immunosuppressive Agents Phase 4,Phase 3,Phase 1
29 Tocopherols Phase 4
30 Tocotrienols Phase 4
31 methionine Nutraceutical Phase 4,Phase 3,Phase 2
32 Lecithin Nutraceutical Phase 4
33 Olive Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
34 Soy Bean Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
35 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
36 Phytosterol Nutraceutical Phase 4
37 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
38
Trioxsalen Approved Phase 3,Phase 2 3902-71-4 5585
39
Ethanol Approved Phase 3 64-17-5 702
40
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
41
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
42
gamma-Aminobutyric acid Approved, Investigational Phase 3 56-12-2 119
43
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
44
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
45
Copper Approved, Investigational Phase 3 7440-50-8 27099
46
Molybdenum Approved Phase 3 7439-98-7 185498
47
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
48
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
49
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
50
Colchicine Approved Phase 3 64-86-8 2833 6167

Interventional clinical trials:

(show top 50) (show all 312)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
2 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
5 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
6 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
7 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4 ursodeoxycholic acid
8 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
9 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
10 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
11 Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population Completed NCT02539316 Phase 4 Smoflipid;Médialipides
12 Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT Completed NCT03048318 Phase 4
13 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
14 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
15 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
16 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
17 SMOFLipid in Intralipid Intolerant Recruiting NCT03054948 Phase 4 SMOFLipid;Standard therapy
18 Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis Recruiting NCT03355326 Phase 4 Glycerin Suppository
19 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4 Omegaven
20 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
21 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
22 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
23 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Not yet recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
24 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
25 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
26 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
27 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
28 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
29 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
30 Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption Completed NCT02200029 Phase 3 Ademetionine IV+tablet;Ademetionine tablet
31 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
32 Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed NCT02663453 Phase 3 multicomponent lipid emulsion;pure soybean oil lipid emulsion
33 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
34 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3 Gabapentin;Placebo
35 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
36 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
37 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
38 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3 S-1 Chemotherapy
39 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
40 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
41 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
42 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate
43 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3 Combination antiviral therapy;Placebo
44 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3 Methotrexate
45 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3 methotrexate;ursodiol
46 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3 colchicine;methotrexate;ursodiol
47 Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis Recruiting NCT01555957 Phase 3 intravenous lipid
48 Cholestasis Reversal: Efficacy of IV Fish Oil Recruiting NCT00910104 Phase 2, Phase 3 Omegaven®
49 Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants Recruiting NCT02534077 Phase 3 Omegaven;Omegaven;Omegaven
50 Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children Recruiting NCT01194063 Phase 3 Omega-3 fish oil lipid emulsion

Search NIH Clinical Center for Cholestasis

Cochrane evidence based reviews: cholestasis

Genetic Tests for Cholestasis

Genetic tests related to Cholestasis:

# Genetic test Affiliating Genes
1 Cholestasis 28

Anatomical Context for Cholestasis

MalaCards organs/tissues related to Cholestasis:

38
Liver, Placenta, Bone, Testes, Pancreas, Brain, Kidney

Publications for Cholestasis

Articles related to Cholestasis:

(show top 50) (show all 1671)
# Title Authors Year
1
Benign recurrent intrahepatic cholestasis (BRIC)-like episode associated with ATP8B1 variation underlying protracted cholestatic course of acute hepatitis E virus infection. ( 29191380 )
2018
2
Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlations. ( 29412511 )
2018
3
Detection of Cytomegalovirus in Liver Tissue by PCR in Infants with Neonatal Cholestasis. ( 29389827 )
2018
4
Loss-of-Function Mutations in UNC45A Cause a Syndrome Associating Cholestasis, Diarrhea, Impaired Hearing, and Bone Fragility. ( 29429573 )
2018
5
Nutritional therapy complications in children with ultra-short bowel syndrome include growth deficiency but not cholestasis. ( 29405447 )
2018
6
Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage-refractory itch. ( 29404523 )
2018
7
Splicing analysis of rare/novel synonymous or intronic variants identified in ABCB11 heterozygotes presenting as progressive intrahepatic cholestasis with low I^-glutamyltransferase. ( 29316097 )
2018
8
Cholestasis after TIPS placement in a patient with primary sclerosing cholangitis: an uncommon complication. ( 29278002 )
2018
9
Reduced Immunohistochemical Expression of Hnf1I^ and FoxA2 in Liver Tissue Can Discriminate Between Biliary Atresia and Other Causes of Neonatal Cholestasis. ( 29406331 )
2018
10
Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. ( 29427579 )
2018
11
Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? ( 29419378 )
2018
12
SCYL1 variants cause a syndrome with low I^-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). ( 29419818 )
2018
13
The pruritus of cholestasis: From bile acids to opiate agonists: Relevant after all these years. ( 29317077 )
2018
14
Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease. ( 29431335 )
2018
15
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages. ( 29104077 )
2018
16
Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1I+. ( 29360226 )
2018
17
Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target. ( 29328070 )
2018
18
Different effects of ursodeoxycholic acid on intrahepatic cholestasis in acute and recovery stages induced by alpha-naphthylisothiocyanate in mice. ( 29407775 )
2018
19
Chronic cholestasis is associated with hypogonadism and premature ovarian failure in adult rats (cholestasis causes ovarian hypogonadism). ( 29297778 )
2018
20
Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis. ( 28784620 )
2017
21
Ursodeoxycholic Acid Ameliorates Intrahepatic Cholestasis Independent of Biliary Bicarbonate Secretion in Vil2(kd/kd) Mice. ( 28049946 )
2017
22
Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28923092 )
2017
23
Outcomes following partial external biliary diversion in patients with progressive familial intrahepatic cholestasis. ( 27916445 )
2017
24
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
25
Inhibition of JNK signalling mediates PPARI+-dependent protection against intrahepatic cholestasis by fenofibrate. ( 28646549 )
2017
26
Plasma exchange for the management of refractory pruritus of cholestasis: A report of three cases and review of literature. ( 28792089 )
2017
27
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
28
Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland. ( 28785115 )
2017
29
Hepatic fascioliasis presenting with bile duct obstruction: a case report. ( 29158867 )
2017
30
Sensitivity and Specificity of Biochemical Tests for Diagnosis of Intrahepatic Cholestasis of Pregnancy. ( 28611260 )
2017
31
Hepatoprotective activities of rosmarinic acid against extrahepatic cholestasis in rats. ( 28789951 )
2017
32
Correction to: Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28982379 )
2017
33
Protective Effects of Petroleum Ether Extracts of Herpetospermum caudigerum against I+-naphthylisothiocyanate-Induced Acute Cholestasis of Rats. ( 28065777 )
2017
34
Intrahepatic Cholestasis of Pregnancy Refractory to Multiple Medical Therapies and Plasmapheresis. ( 29250459 )
2017
35
Organic Solute Transporter-beta (SLC51B) Deficiency in Two Brothers with Congenital Diarrhea and Features of Cholestasis. ( 28898457 )
2017
36
Effect of intrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis. ( 28825589 )
2017
37
A Rare BSEP Mutation Associated with a Mild Form of Progressive Familial Intrahepatic Cholestasis Type 2. ( 28425419 )
2017
38
Intrahepatic cholestasis in two omani siblings associated with a novel homozygous ATP8B1 mutation, c.379C>G (p.L127V). ( 28937026 )
2017
39
Parenteral nutrition-associated cholestasis and triglyceridemia in surgical term and near-term neonates: A pilot randomized controlled trial of two mixed intravenous lipid emulsions. ( 29415837 )
2017
40
Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy. ( 28233754 )
2017
41
Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis. ( 28936401 )
2017
42
Maternal copeptin levels in intrahepatic cholestasis of pregnancy. ( 28552021 )
2017
43
Bile acid levels and risk of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy: A meta-analysis. ( 28691322 )
2017
44
Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats. ( 27988401 )
2017
45
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. ( 28049044 )
2017
46
Severe Cholestasis and Bile Cast Nephropathy Induced by Anabolic Steroids Successfully Treated with Plasma Exchange. ( 29391869 )
2017
47
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ( 28570655 )
2017
48
Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report. ( 28838453 )
2017
49
Cholestasis and Hepatic Iron Deposition in an Infant With Complex Glycerol Kinase Deficiency. ( 28759390 )
2017
50
Liver transplantation for decompensated liver cirrhosis caused by progressive familial intrahepatic cholestasis type 3: A case report. ( 29390323 )
2017

Variations for Cholestasis

Expression for Cholestasis

Search GEO for disease gene expression data for Cholestasis.

Pathways for Cholestasis

Pathways related to Cholestasis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ABCB11 ABCC3 CYP7A1 HSD3B7 NR1H4 SLC10A1
2 11.97 ABCC2 ABCC3 ABCC4 GGT1
3
Show member pathways
11.89 ABCB11 ABCB4 ABCC2 SLC10A1
4
Show member pathways
11.71 NR1H4 NR1I2 NR1I3
5
Show member pathways
11.67 ABCB11 ABCC2 ABCC4
6
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
7 11.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
8
Show member pathways
11.45 ABCC2 NR1I2 NR1I3
9 11.16 ABCC2 ABCC3 NR1I3
10 11.12 ABCC2 ABCC3 ABCC4
11 10.99 ABCC2 ABCC3 ABCC4
12 10.93 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
13
Show member pathways
10.88 ABCC2 ABCC3 ABCC4
14 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
15 10.8 ABCC2 ABCC3 ABCC4
16 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
17 10.76 ABCC3 NR1I2
18 10.68 ABCC2 NR1I2
19 10.54 ABCC2 ABCC3

GO Terms for Cholestasis

Cellular components related to Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.67 ABCB4 ABCC2 ATP8B1 JAG1
2 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 apical part of cell GO:0045177 9.43 ABCB11 ABCB4 JAG1
4 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
5 HOPS complex GO:0030897 9.32 VIPAS39 VPS33B
6 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
7 membrane GO:0016020 10.28 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

Biological processes related to Cholestasis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.95 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 response to organic substance GO:0010033 9.75 ABCB4 ABCC4 TJP2
3 steroid hormone mediated signaling pathway GO:0043401 9.71 NR1H4 NR1I2 NR1I3
4 intracellular receptor signaling pathway GO:0030522 9.65 NR1H4 NR1I2 NR1I3
5 bile acid biosynthetic process GO:0006699 9.61 ABCB11 CYP7A1 HSD3B7
6 phospholipid translocation GO:0045332 9.59 ABCB4 ATP8B1
7 intestinal absorption GO:0050892 9.58 ABCB4 TJP2
8 response to glucagon GO:0033762 9.57 ABCB4 ABCC2
9 bile acid metabolic process GO:0008206 9.56 ATP8B1 NR1H4
10 collagen metabolic process GO:0032963 9.55 VIPAS39 VPS33B
11 peptidyl-lysine hydroxylation GO:0017185 9.52 VIPAS39 VPS33B
12 response to antineoplastic agent GO:0097327 9.51 ABCB4 ABCC2
13 xenobiotic transport GO:0042908 9.5 ABCB4 ABCC3 NR1I2
14 drug export GO:0046618 9.49 ABCB4 NR1I2
15 regulation of bile acid biosynthetic process GO:0070857 9.46 CYP7A1 NR1H4
16 drug transmembrane transport GO:0006855 9.46 ABCB4 ABCC2 ABCC3 ATP8B1
17 canalicular bile acid transport GO:0015722 9.43 ABCB11 ABCC2 ABCC3
18 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.26 ABCB11 ABCC2 ABCC3 ABCC4
19 bile acid and bile salt transport GO:0015721 9.02 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1
20 transport GO:0006810 10.07 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Molecular functions related to Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.67 ABCB11 ABCC2 ABCC3 SLC25A13
2 ATPase activity GO:0016887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
3 steroid hormone receptor activity GO:0003707 9.61 NR1H4 NR1I2 NR1I3
4 nuclear receptor activity GO:0004879 9.58 NR1H4 NR1I2 NR1I3
5 organic anion transmembrane transporter activity GO:0008514 9.48 ABCC2 ABCC3
6 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.46 ABCB4 ABCC3
7 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
8 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
9 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
10 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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