MCID: CHL068
MIFTS: 58

Cholestasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Cholestasis

MalaCards integrated aliases for Cholestasis:

Name: Cholestasis 12 29 52 42 14 69
Obstruction of Bile Duct 12
Bile Duct Obstruction 52
Bile Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13580
ICD10 33 K83.1
ICD9CM 35 576.2
MeSH 42 D002779
NCIt 47 C83006
UMLS 69 C0008370

Summaries for Cholestasis

MalaCards based summary : Cholestasis, also known as obstruction of bile duct, is related to cholestasis, intrahepatic, of pregnancy, 1 and cholestasis, intrahepatic, of pregnancy, 3, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Synthesis of bile acids and bile salts and NRF2 pathway. The drugs Ursodeoxycholic acid and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related phenotypes are Downregulation of NF-kappaB pathway after TNFalpha stimulation and growth/size/body region

Wikipedia : 72 Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic... more...

Related Diseases for Cholestasis

Diseases related to Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
id Related Disease Score Top Affiliating Genes
1 cholestasis, intrahepatic, of pregnancy, 1 34.0 ABCB11 ATP8B1
2 cholestasis, intrahepatic, of pregnancy, 3 33.8 ABCB11 ABCB4 ATP8B1 JAG1
3 cholestasis, benign recurrent intrahepatic, 2 33.6 ABCB11 ABCB4 ATP8B1 NR1H4 TJP2
4 cholestasis, benign recurrent intrahepatic 33.5 ABCB11 ABCB4 ATP8B1 GGT1 JAG1 NR1H4
5 eclampsia 22.6 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP
6 intrahepatic cholestasis 12.4
7 cholestasis, progressive familial intrahepatic 1 12.3
8 cholestasis-lymphedema syndrome 12.2
9 arthrogryposis, renal dysfunction, and cholestasis 1 12.1
10 cholestasis, progressive familial intrahepatic 3 12.1
11 cholestasis, progressive familial intrahepatic 2 12.1
12 cholestasis, progressive familial intrahepatic, 5 12.1
13 cholestasis, progressive familial intrahepatic 4 12.1
14 arthrogryposis, renal dysfunction, and cholestasis 2 12.0
15 extrahepatic cholestasis 12.0
16 low gamma-gt familial intrahepatic cholestasis 11.9
17 cholestasis, familial intrahepatic, of pregnancy 1 11.7
18 vipas39-related arthrogryposis, renal dysfunction, and cholestasis syndrome 11.7
19 vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome 11.7
20 cholestasis, familial intrahepatic, of pregnancy 3 11.6
21 abcb11-related intrahepatic cholestasis 11.6
22 myo5b-related progressive familial intrahepatic cholestasis 11.6
23 atp8b1-related intrahepatic cholestasis 11.6
24 citrullinemia, type ii, neonatal-onset 11.6
25 bile acid synthesis defect, congenital, 2 11.6
26 gracile syndrome 11.6
27 bile acid synthesis defect, congenital, 1 11.5
28 alagille syndrome 1 11.5
29 bile acid synthesis defect, congenital, 4 11.4
30 alagille syndrome 2 11.2
31 hardikar syndrome 11.1
32 biliary atresia 11.0
33 crigler-najjar syndrome, type ii 11.0
34 hyperbiliverdinemia 10.9
35 gallbladder disease 1 10.9
36 sclerosing cholangitis, neonatal 10.8
37 bile acid synthesis defect, congenital, 3 10.8
38 cortisone reductase deficiency 10.8 VIPAS39 VPS33B
39 alport syndrome and thin basement membrane nephropathy 10.7 ABCB11 ATP8B1 NR1H4
40 congenital bile acid synthesis defect 10.7
41 glycogen storage disease xii 10.7 HSD3B7 TJP2
42 bile duct carcinoma 10.6
43 amyloidosis, familial visceral 10.6
44 mitochondrial dna depletion syndrome 15 10.6
45 north american indian childhood cirrhosis 10.6
46 nephronophthisis 19 10.6
47 lathosterolosis 10.6
48 caroli disease 10.6
49 interstitial lung and liver disease 10.6
50 citrullinemia, adult-onset type ii 10.6

Comorbidity relations with Cholestasis via Phenotypic Disease Network (PDN): (show all 17)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Biliary Tract Neoplasm
Cholangitis Cholecystitis
Deficiency Anemia Duodenum Cancer
Esophagitis Gallbladder Cancer
Gastrointestinal System Cancer Intrahepatic Gall Duct Cancer
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholestasis:



Diseases related to Cholestasis

Symptoms & Phenotypes for Cholestasis

UMLS symptoms related to Cholestasis:


icterus, jaundice (not of newborn)

GenomeRNAi Phenotypes related to Cholestasis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Downregulation of NF-kappaB pathway after TNFalpha stimulation GR00199-A-2 8.8 NR1H4 TJP2 UTP4

MGI Mouse Phenotypes related to Cholestasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ABCB11 ABCB4 ABCC4 ATP8B1 CYP7A1 GGT1
2 homeostasis/metabolism MP:0005376 10.13 NR1H4 NR1I2 NR1I3 SLC25A13 VPS33B ABCB11
3 integument MP:0010771 9.81 ABCC3 ABCC4 CYP7A1 GGT1 HSD3B7 JAG1
4 liver/biliary system MP:0005370 9.73 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CYP7A1
5 mortality/aging MP:0010768 9.44 ABCB11 ABCC4 ATP8B1 CYP7A1 GGT1 HSD3B7

Drugs & Therapeutics for Cholestasis

Drugs for Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
2
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
3
Abatacept Approved Phase 4 332348-12-6 10237
4
Sorbitol Approved Phase 4 50-70-4 5780
5
Choline Approved, Nutraceutical Phase 4 62-49-7 305
6 Coconut Approved, Nutraceutical Phase 4
7 Tocopherol Approved, Nutraceutical Phase 4
8
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
9 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
11 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
12 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Nootropic Agents Phase 4
15 Polyene phosphatidylcholine Phase 4
16 Bile Acids and Salts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
18 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
19 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 3,Phase 1
20 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
21 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 3,Phase 1
22 Cholagogues and Choleretics Phase 4,Phase 2,Phase 3,Phase 1
23 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
24 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
25 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 1
27 Tocopherols Phase 4
28 Tocotrienols Phase 4
29 methionine Nutraceutical Phase 4,Phase 3,Phase 2
30 Lecithin Nutraceutical Phase 4
31 Olive Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
32 Soy Bean Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
33 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
34 Phytosterol Nutraceutical Phase 4
35 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
36
Ethanol Approved Phase 3 64-17-5 702
37
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
38
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
39
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
40
Trioxsalen Approved Phase 3,Phase 2 3902-71-4 5585
41
Bezafibrate Approved Phase 3 41859-67-0 39042
42
Copper Approved Phase 3 7440-50-8 27099
43
Molybdenum Approved Phase 3 7439-98-7 185498
44
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
45
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
46
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
47
Colchicine Approved Phase 3 64-86-8 6167 2833
48
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
49
Budesonide Approved Phase 3,Phase 1 51333-22-3 63006 5281004
50
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091

Interventional clinical trials:

(show top 50) (show all 297)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
2 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
5 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
6 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4 ursodeoxycholic acid
7 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
8 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
9 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
10 Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population Completed NCT02539316 Phase 4 Smoflipid;Médialipides
11 Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT Completed NCT03048318 Phase 4
12 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
13 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
14 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
15 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
16 SMOFLipid in Intralipid Intolerant Recruiting NCT03054948 Phase 4 SMOFLipid;Standard therapy
17 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4 Omegaven
18 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
19 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
20 Preventing Cholestasis Using SMOFLipid® Active, not recruiting NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
21 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
22 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
23 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
24 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
25 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
26 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Unknown status NCT00753441 Phase 2, Phase 3
27 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
28 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
29 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
30 Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption Completed NCT02200029 Phase 3 Ademetionine IV+tablet;Ademetionine tablet
31 Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed NCT02663453 Phase 3 multicomponent lipid emulsion;pure soybean oil lipid emulsion
32 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
33 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3 Gabapentin;Placebo
34 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
35 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
36 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
37 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3 S-1 Chemotherapy
38 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
39 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
40 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
41 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate
42 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3 Combination antiviral therapy;Placebo
43 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3 Methotrexate
44 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3 methotrexate;ursodiol
45 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3 colchicine;methotrexate;ursodiol
46 Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis Recruiting NCT01555957 Phase 3 intravenous lipid
47 Cholestasis Reversal: Efficacy of IV Fish Oil Recruiting NCT00910104 Phase 2, Phase 3 Omegaven®
48 Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants Recruiting NCT02534077 Phase 3 Omegaven;Omegaven;Omegaven
49 Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children Recruiting NCT01194063 Phase 3 Omega-3 fish oil lipid emulsion
50 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02823366 Phase 3 Fenofibrate;UDCA

Search NIH Clinical Center for Cholestasis

Cochrane evidence based reviews: cholestasis

Genetic Tests for Cholestasis

Genetic tests related to Cholestasis:

id Genetic test Affiliating Genes
1 Cholestasis 29

Anatomical Context for Cholestasis

MalaCards organs/tissues related to Cholestasis:

39
Liver, Placenta, Bone, Testes, Brain, Heart, Kidney

Publications for Cholestasis

Articles related to Cholestasis:

(show top 50) (show all 1609)
id Title Authors Year
1
Bile acid levels and risk of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy: A meta-analysis. ( 28691322 )
2017
2
A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population. ( 28926728 )
2017
3
Inhibition of JNK signalling mediates PPARI+-dependent protection against intrahepatic cholestasis by fenofibrate. ( 28646549 )
2017
4
Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland. ( 28785115 )
2017
5
Prognostic roles of tetrahydroxy bile acids in infantile intrahepatic cholestasis. ( 28073941 )
2017
6
Sickle cell intrahepatic cholestasis unresponsive to exchange blood transfusion: a case report. ( 28577654 )
2017
7
Outcomes following partial external biliary diversion in patients with progressive familial intrahepatic cholestasis. ( 27916445 )
2017
8
Urinary metabolomic analysis of intrahepatic cholestasis of pregnancy based on high performance liquid chromatography/mass spectrometry. ( 28669684 )
2017
9
Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28923092 )
2017
10
Intrahepatic cholestasis in two omani siblings associated with a novel homozygous ATP8B1 mutation, c.379C>G (p.L127V). ( 28937026 )
2017
11
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
12
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ( 28570655 )
2017
13
Living Donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 1: Two Reported Cases. ( 28583540 )
2017
14
p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. ( 28910492 )
2017
15
Congenital Hepatic Fibrosis with Polycystic Kidney Disease: An Unusual Cause of Neonatal Cholestasis. ( 28737145 )
2017
16
Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis. ( 28936401 )
2017
17
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
18
A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. ( 28603204 )
2017
19
miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3. ( 28575098 )
2017
20
Effect of intrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis. ( 28825589 )
2017
21
Cholestasis and Hepatic Iron Deposition in an Infant With Complex Glycerol Kinase Deficiency. ( 28759390 )
2017
22
Perinatal outcomes associated with intrahepatic cholestasis of pregnancy(). ( 28581354 )
2017
23
Two cases of first onset intrahepatic cholestasis of pregnancy associated with moderate ovarian hyperstimulation syndrome after IVF treatment and review of the literature. ( 28319428 )
2017
24
Plasma exchange for the management of refractory pruritus of cholestasis: A report of three cases and review of literature. ( 28792089 )
2017
25
Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis. ( 28784620 )
2017
26
Chronic Pruritus in an 18-Month-Old Male Infant Due to Anicteric Cholestasis. ( 28082665 )
2017
27
Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy. ( 28233754 )
2017
28
Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry. ( 28937538 )
2017
29
Ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy: Results in real-world conditions and factors predictive of response to treatment. ( 27825922 )
2017
30
Sensitivity and Specificity of Biochemical Tests for Diagnosis of Intrahepatic Cholestasis of Pregnancy. ( 28611260 )
2017
31
Canalicular cholestasis induced by anabolic steroids. ( 28929774 )
2017
32
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. ( 28049044 )
2017
33
Sequencing of transporter genes in cholestasis: We are still learning. ( 28837833 )
2017
34
Interventions for treating intrahepatic cholestasis in people with sickle cell disease. ( 28759700 )
2017
35
Solid Liver Lesions in an Infant With Neonatal Cholestasis: Is it Always Malignant? ( 28816798 )
2017
36
Protective Effects of Petroleum Ether Extracts of Herpetospermum caudigerum against I+-naphthylisothiocyanate-Induced Acute Cholestasis of Rats. ( 28065777 )
2017
37
An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy. ( 28924228 )
2017
38
Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-I+ in Patients with Intrahepatic Cholestasis of Pregnancy. ( 28697498 )
2017
39
Organic Solute Transporter-beta (SLC51B) Deficiency in Two Brothers with Congenital Diarrhea and Features of Cholestasis. ( 28898457 )
2017
40
Maternal copeptin levels in intrahepatic cholestasis of pregnancy. ( 28552021 )
2017
41
Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats. ( 27988401 )
2017
42
Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report. ( 28838453 )
2017
43
Hepatoprotective activities of rosmarinic acid against extrahepatic cholestasis in rats. ( 28789951 )
2017
44
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. ( 28792861 )
2017
45
CCBE1 Mutation causing Sclerosing Cholangitis - Expanding the Spectrum of Lymphedema-Cholestasis Syndrome. ( 28073151 )
2017
46
Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis. ( 28934223 )
2017
47
Ursodeoxycholic Acid Ameliorates Intrahepatic Cholestasis Independent of Biliary Bicarbonate Secretion in Vil2(kd/kd) Mice. ( 28049946 )
2017
48
Hepatic Tmem30a deficiency causes intrahepatic cholestasis by impairing expression and localization of bile salt transporters. ( 28919113 )
2017
49
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. ( 26888176 )
2016
50
A CHALLENGING CASE OF SEVERE INFANTILE CHOLESTASIS IN ALPHA-1 ANTITRYPSIN DEFICIENCY. ( 26855337 )
2016

Variations for Cholestasis

Expression for Cholestasis

Search GEO for disease gene expression data for Cholestasis.

Pathways for Cholestasis

Pathways related to Cholestasis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ABCB11 ABCC3 CYP7A1 HSD3B7 NR1H4 SLC10A1
2 11.97 ABCC2 ABCC3 ABCC4 GGT1
3
Show member pathways
11.89 ABCB11 ABCB4 ABCC2 SLC10A1
4
Show member pathways
11.71 NR1H4 NR1I2 NR1I3
5
Show member pathways
11.67 ABCB11 ABCC2 ABCC4
6
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
7 11.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
8
Show member pathways
11.45 ABCC2 NR1I2 NR1I3
9 11.16 ABCC2 ABCC3 NR1I3
10 11.12 ABCC2 ABCC3 ABCC4
11 10.99 ABCC2 ABCC3 ABCC4
12 10.93 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
13
Show member pathways
10.88 ABCC2 ABCC3 ABCC4
14 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
15 10.8 ABCC2 ABCC3 ABCC4
16 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
17 10.76 ABCC3 NR1I2
18 10.68 ABCC2 NR1I2
19 10.54 ABCC2 ABCC3

GO Terms for Cholestasis

Cellular components related to Cholestasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.67 ABCB4 ABCC2 ATP8B1 JAG1
2 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 apical part of cell GO:0045177 9.43 ABCB11 ABCB4 JAG1
4 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
5 HOPS complex GO:0030897 9.32 VIPAS39 VPS33B
6 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
7 membrane GO:0016020 10.28 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

Biological processes related to Cholestasis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.91 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 response to organic substance GO:0010033 9.72 ABCB4 ABCC4 TJP2
3 steroid hormone mediated signaling pathway GO:0043401 9.7 NR1H4 NR1I2 NR1I3
4 intracellular receptor signaling pathway GO:0030522 9.65 NR1H4 NR1I2 NR1I3
5 bile acid biosynthetic process GO:0006699 9.61 ABCB11 CYP7A1 HSD3B7
6 phospholipid translocation GO:0045332 9.57 ABCB4 ATP8B1
7 intestinal absorption GO:0050892 9.56 ABCB4 TJP2
8 bile acid metabolic process GO:0008206 9.54 ATP8B1 NR1H4
9 drug export GO:0046618 9.51 ABCB4 NR1I2
10 xenobiotic transport GO:0042908 9.5 ABCB4 ABCC3 NR1I2
11 response to antineoplastic agent GO:0097327 9.49 ABCB4 ABCC2
12 regulation of bile acid biosynthetic process GO:0070857 9.46 CYP7A1 NR1H4
13 drug transmembrane transport GO:0006855 9.46 ABCB4 ABCC2 ABCC3 ATP8B1
14 canalicular bile acid transport GO:0015722 9.26 ABCB11 ABCC2
15 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.26 ABCB11 ABCC2 ABCC3 ABCC4
16 bile acid and bile salt transport GO:0015721 9.02 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1
17 transport GO:0006810 10.1 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Molecular functions related to Cholestasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.71 ABCB11 ABCC2 ABCC3 SLC25A13
2 ATPase activity GO:0016887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
3 steroid hormone receptor activity GO:0003707 9.61 NR1H4 NR1I2 NR1I3
4 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.54 NR1H4 NR1I2 NR1I3
5 organic anion transmembrane transporter activity GO:0008514 9.48 ABCC2 ABCC3
6 xenobiotic-transporting ATPase activity GO:0008559 9.46 ABCB4 ABCC3
7 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
8 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
9 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
10 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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