MCID: CHL069
MIFTS: 51

Cholesteatoma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cholesteatoma

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Aliases & Descriptions for Cholesteatoma:

Name: Cholesteatoma 11 46 13 48 37 66
Secondary Acquired Cholesteatoma 46
 
Primary Acquired Cholesteatoma 46
Congenital Cholesteatoma 46

Classifications:



External Ids:

Disease Ontology11 DOID:869
ICD1028 H71.9, H71.90
ICD9CM30 385.30
MeSH37 D002781
NCIt43 C2944

Summaries for Cholesteatoma

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NIH Rare Diseases:46 Cholesteatoma is a type of skin cyst located in the middle ear. it can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. the hallmark symptom is a painless discharge from the ear.hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. surgery can stop infections and prevent complications.   last updated: 12/30/2009

MalaCards based summary: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to otosclerosis and neuroma, and has symptoms including earache, erythematous ear canal and auricular swelling. An important gene associated with Cholesteatoma is KRT10 (Keratin 10), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. Affiliated tissues include middle ear, bone and skin, and related mouse phenotypes are integument and respiratory system.

Disease Ontology:11 A keratosis characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.

Wikipedia:69 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma

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Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1otosclerosis30.4DEFB4A, KRT16
2neuroma30.0MMP9, TNFRSF11B, TNFSF11
3cholesteatoma of middle ear12.4
4cholesteatoma of external ear12.2
5maxillary sinus cholesteatoma12.2
6cholesteatoma of attic12.0
7diabetic cataract10.8IL1A, MMP9
8follicular mucinosis10.7MMP9, TNFSF11
9angioimmunoblastic lymphadenopathy with dysproteinemia10.7DEFB4A, MMP9
10ichthyosis histrix, curth-macklin type10.6KRT10, KRT16
11small intestine lymphoma10.6IL1A, TNF
12otitis media10.5
13classic endocrine tumor of appendix10.5FLG, MMP9
14scrotum paget's disease10.5FGF2, TNF
15epstein-barr virus hepatitis10.5IL1A, TNF
16osteopetrosis, autosomal recessive 710.5TNFRSF11B, TNFSF11
17gonococcal synovitis10.5MMP9, TNF
18hemorrhagic shock and encephalopathy syndrome10.5TNFRSF11B, TNFSF11
19craniodiaphyseal dysplasia, autosomal dominant10.5KRT10, KRT16
20tibial hemimelia10.5TNFRSF11B, TNFSF11
21myopia10.5TNFRSF11B, TNFSF11
22solar retinopathy10.4TNFRSF11B, TNFSF11
23neonatal period electroclinical syndrome10.4IL1A, MMP9, TNF
24astrocytoma10.4IL1A, TNF
25epidermolytic acanthoma10.4KRT10, KRT14
26large cell carcinoma with rhabdoid phenotype10.4FGF2, MMP9, TNF
27juvenile retinoschisis10.4TNFRSF11B, TNFSF11
28malignant giant cell tumor10.4MMP9, TNF, TNFSF11
29gingivitis10.4IL1A, MMP9, TNF
30complex lethal osteochondrodysplasia10.4KRT10, KRT16
31mastoiditis10.4
32blepharochalasis10.4MMP9, TNF, TNFSF11
33lymphangioma10.4IL1A, TNF, TNFSF11
34brachydactyly type a310.4FLG, KRT10
35pleomorphic lipoma10.4IL1A, TNF, TNFSF11
36metatypical basal cell carcinoma10.4KRT10, KRT14
37hypothyroidism10.4KRT16, TNF
38hemoglobin d disease10.4KRT10, KRT14
39gastric squamous cell carcinoma10.4KRT10, KRT14
40suppurative otitis media10.4
41liver disease10.3IL1A, KRT13, KRT14
42inflammatory liposarcoma10.3MMP9, TNFRSF11B, TNFSF11
43conjunctiva squamous cell carcinoma10.3FGFR2, KRT10
44accessory nerve disease10.3DEFB4A, IL1A, TNF
45anaerobic meningitis10.3IL1A, TNFRSF11B, TNFSF11
46cannabis dependence10.3MMP9, TNFRSF11B, TNFSF11
47zellweger-like syndrome without peroxisomal anomalies10.3MMP2, MMP9
48nerve root neoplasm10.2KRT10, KRT13, KRT14
49pathological gambling10.2MMP2, MMP9
50myosin storage myopathy10.2MMP2, MMP9

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Symptoms for Cholesteatoma

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UMLS symptoms related to Cholesteatoma:


earache, erythematous ear canal, auricular swelling, ear congestion, itching of ear, paraesthesia ear

Drugs & Therapeutics for Cholesteatoma

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Drugs for Cholesteatoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
clonidinePhase 22194205-90-72803
Synonyms:
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI)
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
2,6-dichloro-N-(2-imidazolidinylidene)aniline
2,6-dichloro-N-2-imidazolidinylidenebenzenamide
2,6-dichloro-N-imidazolidin-2-ylideneaniline
2-((2,6-Dichlorophenyl)imino)imidazolidine
2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
2-(2,6-Dichloroanilino)-2-imidazoline
2-(2,6-Dichlorophenylamino)-2-imidazoline
2-(2,6-Dichlorophenylimino)imidazolidine
2-Imidazoline, 2-(2,6-dichloroanilino)- (7CI,8CI)
2-[(2,6-Dichlorophenyl)imino]imidazoline
2-[(2,6-dichlorophenyl)imino]-2-imidazoline
4205-90-7
4205-91-8 (mono-hydrochloride)
57066-25-8
734571A
AB00514634
AC1L1EI5
AC1Q3K6V
AKOS001595470
Adesipress
BIDD:GT0547
BPBio1_000040
BRD-K98530306-001-02-1
BRD-K98530306-003-05-0
BSPBio_000036
BSPBio_001588
BSPBio_002055
Bio1_000470
Bio1_000959
Bio1_001448
Bio2_000308
Bio2_000788
C9H9Cl2N3
CAS-4205-91-8
CATAPRES-TTS-1
CATAPRES-TTS-2
CATAPRES-TTS-3
CCRIS 7787
CHEBI:3757
CHEBI:46632
CHEMBL134
CID2803
Catapres
Catapres- TTS
Catapres-TTS
Catapresan
Catapressan
Catarpres
Catarpres-TTS
Catarpres-TTS (TN)
Catarpresan
Chlofazoline
Chlornidinum
Clofenil
Clonidin
Clonidina
Clonidina [INN-Spanish]
Clonidine (JAN/USAN/INN)
Clonidine HCl
Clonidine [USAN:BAN:INN]
Clonidinhydrochlorid
Clonidinum
Clonidinum [INN-Latin]
Clonistada
Clopheline
D00281
DB00575
DB07566
DivK1c_000774
 
Dixarit
Duraclon
Duraclont
EINECS 224-119-4
Gemiton
HMS1361P10
HMS1791P10
HMS1989P10
HMS2089G11
HSDB 3040
Hemiton
IDI1_000774
IDI1_034058
Ipotensium
Isoglaucon
KBio1_000774
KBio2_000308
KBio2_001821
KBio2_002876
KBio2_004389
KBio2_005444
KBio2_006957
KBio3_000615
KBio3_000616
KBio3_001275
KBioGR_000308
KBioGR_001572
KBioSS_000308
KBioSS_001821
Klofelin
Klofenil
L000193
LS-79606
Lopac-C-7897
Lopac0_000268
M 5041T
M-5041T
MolPort-001-779-668
MolPort-005-932-374
N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
NCGC00015268-01
NCGC00015268-02
NCGC00015268-08
NCGC00024734-01
NCGC00024734-02
NCGC00024734-03
NCGC00024734-04
NCGC00024734-05
NCGC00179680-01
NINDS_000774
Prestwick0_000248
Prestwick1_000248
Prestwick2_000248
Prestwick3_000248
SKF 34427
SPBio_001233
SPBio_002255
ST 155BS
ST-155-BS
ST-155BS
Spectrum2_001187
Spectrum3_000358
Spectrum4_000956
Spectrum5_000759
Spectrum_001341
T171
Tenso-Timelets
Tocris-0690
UNII-MN3L5RMN02
ZINC00896484
clonidine
nchembio.79-comp11
nchembio705-10
2
BupivacainePhase 210562180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis MediaActive, not recruitingNCT00270660Phase 3
2Great Auricular Nerve Block for Tympanomastoid Surgery: Will the Addition of Clonidine Enhance the Duration of Analgesia?CompletedNCT01638052Phase 2
3Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in ChildrenCompletedNCT00682409
4Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
5Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
6Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
7Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
8Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma


Cochrane evidence based reviews: cholesteatoma

Genetic Tests for Cholesteatoma

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Anatomical Context for Cholesteatoma

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MalaCards organs/tissues related to Cholesteatoma:

34
Bone, Skin, Brain, Testes, Endothelial, Temporal lobe, Neutrophil

FMA organs/tissues related to Cholesteatoma:

17
Middle ear

Animal Models for Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4FGFR2, IL1A, KRT14, KRT16, MMP9, TNF
2MP:00053888.1FGFR2, KRT14, MMP2, MMP9, TNF, TNFSF11
3MP:00053827.8FGFR2, KRT14, KRT16, MMP2, TNF, TNFRSF11B
4MP:00020067.2FGF2, FGFR2, IL1A, KRT14, MMP2, MMP9
5MP:00053917.2FGF2, FGFR2, KRT14, MMP2, MMP9, TNF
6MP:00053976.3FGF2, FGFR2, IL1A, KRT14, MMP2, MMP9

Publications for Cholesteatoma

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Articles related to Cholesteatoma:

(show top 50)    (show all 865)
idTitleAuthorsYear
1
Tubal function tests with optional myringotomy detect Eustachian tube closing failure in acquired pars flaccida retraction cholesteatoma. (27427536)
2016
2
Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. (27117903)
2016
3
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
4
Health-related quality of life measurement after cholesteatoma surgery: comparison of three different surgical techniques. (25359196)
2014
5
Recurrent aseptic meningitis as a rare but important presentation of congenital petrous apex cholesteatoma: the value of appropriate imaging. (24614768)
2014
6
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
7
Extradural granulation complicated by chronic suppurative otitis media with cholesteatoma. (24982237)
2014
8
Congenital cholesteatoma in identical twins. (23217274)
2013
9
Differential gene expression in cholesteatoma by DNA chip analysis. (23670528)
2013
10
Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear. (23299781)
2013
11
How long is long enough to follow up children after cholesteatoma surgery? A 29-year study. (23108885)
2012
12
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
13
The pathogenesis of acquired cholesteatoma of the human middle ear: support for the migration hypothesis. (22143292)
2012
14
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
15
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
16
Acquired cholesteatoma: classification and outcomes. (21725267)
2011
17
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
18
Petrous bone cholesteatoma: classification, management and review of the literature. (20668373)
2011
19
Recurrence of cholesteatoma mimicking dural herniation. (24303377)
2011
20
Biofilms in chronic suppurative otitis media and cholesteatoma: scanning electron microscopy findings. (20036033)
2011
21
The utility of diffusion-weighted imaging for cholesteatoma evaluation. (20488909)
2011
22
Bilateral congenital cholesteatoma: report of an emblematic case. (21563559)
2011
23
Osteoplastic atticoantrotomy with autologous bone chips and a bony attic strut in cholesteatoma surgery. (19953260)
2010
24
Mastoid subperiosteal abscess as a first sign of unnoticed cholesteatoma in children. (19814752)
2010
25
Tympanic membrane cholesteatoma: a rare finding. (20718191)
2010
26
Management of complex cases of petrous bone cholesteatoma. (20860276)
2010
27
Diffusion-weighted MR imaging in postoperative follow-up: reliability for detection of recurrent cholesteatoma. (19231123)
2010
28
The ongoing dilemma of residual cholesteatoma detection: are current magnetic resonance imaging techniques good enough? (20202277)
2010
29
Canal wall-down mastoidectomy with mastoid obliteration for pediatric cholesteatoma. (19565369)
2010
30
External auditory canal cholesteatoma: a rare complication of tympanoplasty. (19924662)
2009
31
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
32
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (18419858)
2008
33
Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. (19144300)
2008
34
Endoscope-assisted surgery via the middle cranial fossa approach for a petrous cholesteatoma. (18226484)
2008
35
Giant Cholesteatoma: Recommendations for Follow-up. (19240835)
2008
36
Transforming growth factor beta and wound healing in human cholesteatoma. (17989584)
2008
37
The value of magnetic resonance imaging in the diagnosis of residual or recurrent acquired cholesteatoma after canal wall-up tympanoplasty. (18199952)
2008
38
Staged tympanostomy tube placement facilitates pediatric cholesteatoma management. (18023884)
2008
39
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
40
Applicability of autologous incus: the influence of age and localization of cholesteatoma. (17415579)
2007
41
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
42
Petrous bone cholesteatoma: clinical longitudinal study. (17082945)
2007
43
A new case of synchronous primary external ear canal cholesteatoma. (16730556)
2006
44
Some markers of proliferative activity in cholesteatoma epithelium in adults. (16865065)
2006
45
Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture. (15875782)
2005
46
Sustained extracellular signal-regulated kinase1/2 mitogen-activated protein kinase signalling is related to increased p21 expression in cholesteatoma epithelium. (15880942)
2005
47
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
48
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
49
Roles of cytokines and cell cycle regulating substances in proliferation of cholesteatoma epithelium. (10401849)
1999
50
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991

Variations for Cholesteatoma

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Expression for genes affiliated with Cholesteatoma

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Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

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GO Terms for genes affiliated with Cholesteatoma

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Cellular components related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.4FLG, KRT10, KRT14, KRT16
2extracellular spaceGO:00056156.4DEFB4A, FGF2, IL1A, KRT10, LGALS8, MMP2
3extracellular regionGO:00055766.2DEFB4A, FGF2, FGFR2, IL1A, MMP2, MMP9

Biological processes related to Cholesteatoma according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1hair cycleGO:004263310.4KRT14, KRT16
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3FGFR2, TNF
3positive regulation of osteoclast differentiationGO:004567210.2TNF, TNFSF11
4regulation of osteoclast differentiationGO:004567010.2TNF, TNFSF11
5keratinocyte differentiationGO:003021610.0FLG, KRT10, KRT16
6positive regulation of JNK cascadeGO:00463309.9IL1A, TNF, TNFSF11
7positive regulation of cardiac muscle cell proliferationGO:00600459.8FGF2, FGFR2
8establishment of skin barrierGO:00614369.8FLG, KRT16
9tumor necrosis factor-mediated signaling pathwayGO:00332099.8TNF, TNFRSF11B, TNFSF11
10positive regulation of cell divisionGO:00517819.5FGF2, FGFR2, IL1A
11positive regulation of vascular smooth muscle cell proliferationGO:19047079.5MMP2, MMP9
12positive regulation of smooth muscle cell proliferationGO:00486619.3FGF2, FGFR2, TNF
13positive regulation of protein kinase B signalingGO:00518979.3FGF2, TNF, TNFSF11
14inflammatory responseGO:00069549.2IL1A, KRT16, TNF, TNFRSF11B
15immune responseGO:00069559.1DEFB4A, IL1A, TNFRSF11B, TNFSF11
16positive regulation of MAP kinase activityGO:00434069.0FGF2, TNF, TNFSF11
17animal organ morphogenesisGO:00098878.7FGF2, FGFR2, TNF, TNFSF11
18extracellular matrix organizationGO:00301988.1FGF2, MMP9, TNF, TNFRSF11B

Molecular functions related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.2FGF2, IL1A, TNF, TNFRSF11B, TNFSF11

Sources for Cholesteatoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet