Aliases & Classifications for Cholesteatoma

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Cholesteatoma, Aliases & Descriptions:

Name: Cholesteatoma 9 41 11 43 60
Secondary Acquired Cholesteatoma 41
 
Primary Acquired Cholesteatoma 41
Congenital Cholesteatoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:869
MeSH33 D002781
NCIt38 C2944
ICD9CM27 385.30

Summaries for Cholesteatoma

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NIH Rare Diseases:41 Cholesteatoma is a type of skin cyst located in the middle ear. it can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. the hallmark symptom is a painless discharge from the ear.hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. surgery can stop infections and prevent complications.   last updated: 12/30/2009

MalaCards based summary: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to middle ear cholesteatoma and keratosis. An important gene associated with Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Cytoskeleton remodeling Keratin filaments. The compounds helenalin and dnfb have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Wikipedia:63 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma

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Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1middle ear cholesteatoma31.3DEFB4A, KRT13, IL1A, CHKB, MMP9, TNFSF11
2keratosis30.1KRT16, KRT10, FLG
3congenital ichthyosiform erythroderma30.0KRT10, FLG
4otitis media10.8
5suppurative otitis media10.6
6periodontal disease10.5TNFSF11
7oral candidiasis10.5DEFB4A
8candidiasis10.5DEFB4A
9periapical granuloma10.5TNFSF11
10irritant dermatitis10.4KRT16
11pachyonychia congenita10.4KRT16
12cardiac rupture10.4CHKB
13periodontitis10.4IL1A, MMP9
14synovitis10.4IL1A, TNFSF11
15arthritis10.3TNFSF11, IL1A
16gingivitis10.3IL1A, TNFSF11
17psoriatic arthritis10.3IL1A, TNFSF11
18cholesteatoma of external ear10.3
19tonsillitis10.3DEFB4A, DEFB1
20giant cell tumor10.3TNFSF11, MMP9
21contact dermatitis10.3FLG
22cholesteatoma of attic10.3
23maxillary sinus cholesteatoma10.3
24labyrinthitis10.3
25bone cancer10.3MMP9, TNFSF11
26idiopathic myopathy10.3CHKB, IL1A
27skin disease10.3IL1A, MMP9
28steatocystoma multiplex10.3KRT16, KRT10
29duodenal ulcer10.3DEFB4A, DEFB1
30palmoplantar keratosis10.2KRT16, KRT10
31tympanosclerosis10.2
32facial paralysis10.2
33acne10.2IL1A, DEFB1, DEFB4A
34dermatomyositis10.2CHKB, IL1A
35meningitis10.2
36polymyositis10.2IL1A, CHKB
37sarcoidosis 110.1IL1A, DEFB1, DEFB4A
38hypercalcemia10.1TNFSF11, IL1A
39epidermolytic hyperkeratosis10.1FLG, KRT10
40cork-handlers' disease10.1DEFB4A, DEFB1, MMP9
41cystic fibrosis10.1DEFB4A, DEFB1, KRT13
42ichthyosis lamellar 110.1FLG, KRT10
43osteosarcoma, somatic10.1IL1A, MMP9, TNFSF11
44acute myocardial infarction10.1TNFSF11, MMP9, CHKB
45sensorineural hearing loss10.1
46lateral sinus thrombosis10.1
47fibrous dysplasia10.1
48cervicitis10.1
49middle ear disease10.1
50microtia10.1

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Symptoms for Cholesteatoma

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Drugs & Therapeutics for Cholesteatoma

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Drug clinical trials:

Search ClinicalTrials for Cholesteatoma

Search NIH Clinical Center for Cholesteatoma

Genetic Tests for Cholesteatoma

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Anatomical Context for Cholesteatoma

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MalaCards organs/tissues related to Cholesteatoma:

31
Bone, Skin, Brain, Endothelial, Temporal lobe, Placenta, Monocytes, Neutrophil

Animal Models for Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7TNFSF11, MMP9, CHKB, KRT10
2MP:00053828.1KRT16, KRT10, FLG, TNFSF11
3MP:00107718.1KRT16, KRT10, MMP9, FLG, TNFSF11
4MP:00053877.7DEFB1, TNFSF11, FLG, MMP9, IL1A, KRT10
5MP:00053767.6FLG, MMP9, CHKB, IL1A, KRT16, TNFSF11

Publications for Cholesteatoma

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Articles related to Cholesteatoma:

(show top 50)    (show all 783)
idTitleAuthorsYear
1
Updates and Knowledge Gaps in Cholesteatoma Research. (25866816)
2015
2
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
3
Long-term surgical and functional outcomes of the intact canal wall technique for middle ear cholesteatoma in the paediatric population. (25709151)
2014
4
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
5
Health-related quality of life measurement after cholesteatoma surgery: comparison of three different surgical techniques. (25359196)
2014
6
Recurrent aseptic meningitis as a rare but important presentation of congenital petrous apex cholesteatoma: the value of appropriate imaging. (24614768)
2014
7
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
8
Congenital cholesteatoma in identical twins. (23217274)
2013
9
Letter to the Editor regarding 'Pie-slice tympanoplasty for transcanal removal of small congenital cholesteatoma'. (23415070)
2013
10
Differential gene expression in cholesteatoma by DNA chip analysis. (23670528)
2013
11
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
12
Congenital cholesteatoma of the infratemporal fossa with congenital aural atresia and mastoiditis: a case report. (22731118)
2012
13
Petrous bone cholesteatoma removed by trans-superior semicircular canal approach: long-term hearing results in three cases. (22770523)
2012
14
HASTE diffusion-weighted MRI for the reliable detection of cholesteatoma. (21960134)
2012
15
How long is long enough to follow up children after cholesteatoma surgery? A 29-year study. (23108885)
2012
16
Ossicular erosion in patients requiring surgery for cholesteatoma. (24303397)
2012
17
Cholesteatoma growth and proliferation: relevance with serpin B3. (23239141)
2012
18
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
19
Acquired cholesteatoma: classification and outcomes. (21725267)
2011
20
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
21
Petrous bone cholesteatoma: classification, management and review of the literature. (20668373)
2011
22
Transcanal endoscopic management of cholesteatoma. (20418796)
2010
23
Congenital middle ear cholesteatoma. (21086268)
2010
24
Osteoplastic atticoantrotomy with autologous bone chips and a bony attic strut in cholesteatoma surgery. (19953260)
2010
25
Mastoid subperiosteal abscess as a first sign of unnoticed cholesteatoma in children. (19814752)
2010
26
Tympanic membrane cholesteatoma: a rare finding. (20718191)
2010
27
External auditory canal cholesteatoma: a rare complication of tympanoplasty. (19924662)
2009
28
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
29
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (18419858)
2008
30
Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. (19144300)
2008
31
Residual cholesteatoma: incidence and localization in canal wall down tympanoplasty with soft-wall reconstruction. (18559735)
2008
32
Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl. (19131785)
2008
33
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
34
Applicability of autologous incus: the influence of age and localization of cholesteatoma. (17415579)
2007
35
A new case of synchronous primary external ear canal cholesteatoma. (16730556)
2006
36
The pathophysiology of cholesteatoma. (17097438)
2006
37
Cholesteatoma, cerebrospinal fluid leakage, and chronic otitis media. (16988616)
2006
38
Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture. (15875782)
2005
39
Expression and significance of TERT and c-Myc oncogene protein product on cholesteatoma epithelium]. (16001896)
2005
40
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
41
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
42
Advantages of endoscopically assisted surgery for attic cholesteatoma. (18493554)
2001
43
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
44
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
45
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
46
A study on epidermal proliferation ability in cholesteatoma. (9546266)
1998
47
Clinical and biochemical studies of bone destruction in cholesteatoma. (8763371)
1996
48
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
49
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
50
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990

Variations for Cholesteatoma

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Expression for genes affiliated with Cholesteatoma

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Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

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Pathways related to Cholesteatoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL1A, TNFSF11
29.7KRT13, KRT16
3
Show member pathways
9.7DEFB1, DEFB4A

Compounds for genes affiliated with Cholesteatoma

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Compounds related to Cholesteatoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1helenalin4310.1DEFB4A, MMP9
2dnfb4310.1IL1A, CHKB
3hbd24310.0DEFB1, DEFB4A
47,12-dimethylbenz(a)anthracene439.9CHKB, KRT13
5ns 39843 5910.9IL1A, MMP9, TNFSF11
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.9TNFSF11, MMP9, IL1A
7minocycline43 1210.8MMP9, IL1A
8sp 60012543 5910.8MMP9, TNFSF11, DEFB4A
9procollagen439.8TNFSF11, MMP9, IL1A
10naproxen43 24 1211.8IL1A, CHKB
11polymyxin b439.7DEFB1, TNFSF11, IL1A
12fluvastatin43 49 28 1212.7MMP9, CHKB, IL1A
13prostaglandin439.7IL1A, MMP9, TNFSF11
14geranylgeranyl pyrophosphate439.7TNFSF11, MMP9
15ciprofloxacin43 49 1211.6IL1A, DEFB1
16endotoxin439.6IL1A, CHKB, DEFB4A
17sb 20358043 5910.6IL1A, MMP9, TNFSF11, DEFB4A
18simvastatin43 49 59 28 24 1214.6MMP9, CHKB, IL1A
19genistein43 28 59 2 24 1214.5DEFB4A, TNFSF11, MMP9, IL1A
20isotretinoin43 1210.5KRT16, KRT10, CHKB
21vitamin a43 24 1211.4KRT16, IL1A, MMP9
221,25 dihydroxy vitamin d3439.4TNFSF11, IL1A, KRT10, KRT16
23heparin43 28 24 1212.3DEFB4A, TNFSF11, CHKB, IL1A
24proline439.3MMP9, KRT10, KRT16, KRT13
25nacl439.3DEFB4A, DEFB1, CHKB
26cyclosporin a43 28 5911.3IL1A, CHKB, MMP9, TNFSF11
27hematoxylin439.3KRT10, MMP9, FLG
28pge2439.2TNFSF11, MMP9, CHKB, IL1A
29methotrexate49 43 1211.2CHKB, MMP9, TNFSF11
30creatinine439.2TNFSF11, MMP9, CHKB, IL1A
31dithranol439.2KRT16, KRT10, FLG
32nicotine43 28 49 1212.2FLG, MMP9, IL1A
33latex439.1TNFSF11, FLG, CHKB
34urea43 24 1211.1CHKB, FLG, TNFSF11
35testosterone43 59 24 1212.1TNFSF11, MMP9, CHKB, IL1A
36rantes439.1DEFB4A, DEFB1, TNFSF11, MMP9, IL1A
37vitamin d439.0TNFSF11, CHKB, IL1A, KRT10, KRT13
38calcipotriol43 59 28 1211.9FLG, IL1A, KRT10, KRT16
39estrogen438.9DEFB4A, TNFSF11, MMP9, CHKB, KRT10
40ascorbic acid43 249.9TNFSF11, FLG, CHKB, IL1A
41calcitriol43 59 24 1211.6TNFSF11, FLG, IL1A, KRT10, KRT16
42retinoid438.5KRT16, KRT10, FLG
43cysteine438.5DEFB4A, TNFSF11, FLG, MMP9, CHKB
44nitric oxide43 24 1210.4TNFSF11, FLG, CHKB, IL1A, KRT16
45paraffin438.2KRT13, DEFB4A, TNFSF11, MMP9, CHKB, KRT10
46dexamethasone43 49 28 1211.1DEFB4A, DEFB1, TNFSF11, MMP9, CHKB, IL1A
47serine438.1KRT16, KRT10, IL1A, MMP9, FLG, TNFSF11
48steroid438.1DEFB4A, TNFSF11, FLG, CHKB, KRT10, KRT16
49calcium43 49 24 1210.8DEFB4A, TNFSF11, FLG, MMP9, CHKB, KRT10
50retinoic acid43 248.4DEFB4A, DEFB1, FLG, MMP9, IL1A, KRT10

GO Terms for genes affiliated with Cholesteatoma

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Cellular components related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058828.7KRT16, KRT10, FLG
2extracellular regionGO:00055768.6IL1A, MMP9, TNFSF11, DEFB1, DEFB4A
3extracellular spaceGO:00056158.1TNFSF11, MMP9, LGALS8, IL1A, KRT10

Biological processes related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:00302169.2KRT10, FLG
2immune responseGO:00069558.7IL1A, TNFSF11, DEFB1, DEFB4A

Products for genes affiliated with Cholesteatoma

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Sources for Cholesteatoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet