MCID: CHL069
MIFTS: 48

Cholesteatoma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cholesteatoma

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Aliases & Descriptions for Cholesteatoma:

Name: Cholesteatoma 10 45 47 12 36 65
Secondary Acquired Cholesteatoma 45
 
Primary Acquired Cholesteatoma 45
Congenital Cholesteatoma 45

Classifications:



External Ids:

Disease Ontology10 DOID:869
ICD1027 H71.9, H71.90
ICD9CM29 385.30
MeSH36 D002781
NCIt42 C2944
UMLS65 C0008373

Summaries for Cholesteatoma

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NIH Rare Diseases:45 Cholesteatoma is a type of skin cyst located in the middle ear. it can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. the hallmark symptom is a painless discharge from the ear.hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. surgery can stop infections and prevent complications.   last updated: 12/30/2009

MalaCards based summary: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to hemorrhagic fever and ehlers-danlos syndrome. An important gene associated with Cholesteatoma is LGALS8 (Lectin, Galactoside Binding Soluble 8), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. Affiliated tissues include middle ear, brain and bone, and related mouse phenotypes are integument and craniofacial.

Disease Ontology:10 A keratosis characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.

Wikipedia:68 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma

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Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 605)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever30.0TNFRSF11B, TNFSF11
2ehlers-danlos syndrome29.8MMP2, MMP9
3odontoma29.7MMP2, MMP9
4renal cell carcinoma29.3MMP2, MMP9, TGFA, TNF
5prostate cancer28.2MKI67, MMP2, MMP9, TGFA, TNFRSF11B, TNFSF11
6myeloid leukemia25.3DEFB1, FGF7, IL1A, KRT10, KRT13, KRT14
7cholesteatoma of middle ear12.7
8cholesteatoma of external ear12.6
9maxillary sinus cholesteatoma12.5
10cholesteatoma of attic12.3
11anatomical narrow angle borderline glaucoma10.4IL1A, MMP9
12sclerosteosis 110.4KRT10, KRT16
13liver cirrhosis10.4IL1A, KRT13
14purulent labyrinthitis10.3
15focal labyrinthitis10.3
16pilar sheath acanthoma10.3KRT10, KRT14
17factitious disorder10.3KRT10, KRT16, MMP9
18nodular basal cell carcinoma10.3KRT10, KRT14
19skin pilomatrix carcinoma10.3KRT10, KRT14
20nasal cavity squamous cell carcinoma10.3KRT10, KRT14
21skin disease10.3IL1A, TNF
22paget disease of bone 2, early-onset10.3TNFRSF11B, TNFSF11
23degenerative myopia10.2TNFRSF11B, TNFSF11
24tibial hemimelia10.2TNFRSF11B, TNFSF11
25polycystic bone disease10.2TNFRSF11B, TNFSF11
26lujo hemorrhagic fever10.2IL1A, TNF
27arthritis10.2
28skin squamous cell carcinoma10.2KRT10, KRT16, MKI67
29duodenal somatostatinoma10.2MMP9, TNF
30breast cancer10.2
31hepatitis10.2
32prostatitis10.2
33neuronitis10.2
34perineurioma10.2KRT10, KRT13, KRT14
35intrahepatic biliary papillomatosis10.2TNFRSF11B, TNFSF11
36retinitis pigmentosa 3010.2KRT10, KRT14, KRT16
37leri pleonosteosis10.2MMP2, MMP9
38talo-patello-scaphoid osteolysis10.2MMP2, MMP9
39precursor b lymphoblastic lymphoma/leukemia10.2IL1A, TNF
40rheumatoid arthritis10.2
41leukemia10.2
42lymphoma10.2
43endotheliitis10.2
44entropion10.2MMP2, MMP9
45mixed extragonadal germ cell cancer10.1MMP2, MMP9
46renal pelvis adenocarcinoma10.1MMP2, MMP9
47ovarian clear cell adenocarcinoma10.1KRT14, MKI67
48ganglion or cyst of synovium/tendon/bursa10.1MMP2, MMP9
49spastic diplegia10.1IL1A, KRT13, MMP9, TNFSF11
50funisitis10.1IL1A, MMP9, TNF

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Symptoms for Cholesteatoma

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Drugs & Therapeutics for Cholesteatoma

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Drugs for Cholesteatoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ClonidineapprovedPhase 21894205-90-72803
Synonyms:
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI)
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
2,6-dichloro-N-(2-imidazolidinylidene)aniline
2,6-dichloro-N-2-imidazolidinylidenebenzenamide
2,6-dichloro-N-imidazolidin-2-ylideneaniline
2-((2,6-Dichlorophenyl)imino)imidazolidine
2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
2-(2,6-Dichloroanilino)-2-imidazoline
2-(2,6-Dichlorophenylamino)-2-imidazoline
2-(2,6-Dichlorophenylimino)imidazolidine
2-Imidazoline, 2-(2,6-dichloroanilino)- (7CI,8CI)
2-[(2,6-Dichlorophenyl)imino]imidazoline
2-[(2,6-dichlorophenyl)imino]-2-imidazoline
4205-90-7
4205-91-8 (mono-hydrochloride)
57066-25-8
734571A
AB00514634
AC1L1EI5
AC1Q3K6V
AKOS001595470
Adesipress
BIDD:GT0547
BPBio1_000040
BRD-K98530306-001-02-1
BRD-K98530306-003-05-0
BSPBio_000036
BSPBio_001588
BSPBio_002055
Bio1_000470
Bio1_000959
Bio1_001448
Bio2_000308
Bio2_000788
C9H9Cl2N3
CAS-4205-91-8
CATAPRES-TTS-1
CATAPRES-TTS-2
CATAPRES-TTS-3
CCRIS 7787
CHEBI:3757
CHEBI:46632
CHEMBL134
CID2803
Catapres
Catapres- TTS
Catapres-TTS
Catapresan
Catapressan
Catarpres
Catarpres-TTS
Catarpres-TTS (TN)
Catarpresan
Chlofazoline
Chlornidinum
Clofenil
Clonidin
Clonidina
Clonidina [INN-Spanish]
Clonidine
Clonidine (JAN/USAN/INN)
Clonidine HCl
Clonidine Hydrochloride
Clonidine Transdermal System
Clonidine [USAN:BAN:INN]
Clonidinhydrochlorid
Clonidinum
Clonidinum [INN-Latin]
Clonistada
Clopheline
D00281
DB00575
DB07566
DivK1c_000774
 
Dixarit
Duraclon
Duraclont
EINECS 224-119-4
Gemiton
HMS1361P10
HMS1791P10
HMS1989P10
HMS2089G11
HSDB 3040
Hemiton
IDI1_000774
IDI1_034058
Ipotensium
Isoglaucon
KBio1_000774
KBio2_000308
KBio2_001821
KBio2_002876
KBio2_004389
KBio2_005444
KBio2_006957
KBio3_000615
KBio3_000616
KBio3_001275
KBioGR_000308
KBioGR_001572
KBioSS_000308
KBioSS_001821
Kapvay
Klofelin
Klofenil
L000193
LS-79606
Lopac-C-7897
Lopac0_000268
M 5041T
M-5041T
MolPort-001-779-668
MolPort-005-932-374
N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
NCGC00015268-01
NCGC00015268-02
NCGC00015268-08
NCGC00024734-01
NCGC00024734-02
NCGC00024734-03
NCGC00024734-04
NCGC00024734-05
NCGC00179680-01
NINDS_000774
Nexiclon
Nexiclon Xr
Prestwick0_000248
Prestwick1_000248
Prestwick2_000248
Prestwick3_000248
SKF 34427
SPBio_001233
SPBio_002255
ST 155BS
ST-155-BS
ST-155BS
Spectrum2_001187
Spectrum3_000358
Spectrum4_000956
Spectrum5_000759
Spectrum_001341
T171
Tenso-Timelets
Tocris-0690
UNII-MN3L5RMN02
ZINC00896484
clonidine
nchembio.79-comp11
nchembio705-10
2
Bupivacaineapproved, investigationalPhase 29642180-92-92474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Hydrochloride
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
DepoBupivacaine
 
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
Exparel
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
Racemic bupivacaine
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Vivacaine
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
3Central Nervous System DepressantsPhase 210016
4Neurotransmitter AgentsPhase 214795
5Peripheral Nervous System AgentsPhase 218510
6Antihypertensive AgentsPhase 23618
7Anesthetics, LocalPhase 22347
8Adrenergic alpha-2 Receptor AgonistsPhase 2790
9Adrenergic AgonistsPhase 22331
10Adrenergic alpha-AgonistsPhase 21300
11AnalgesicsPhase 29358
12AnestheticsPhase 27385
13Adrenergic AgentsPhase 24204

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis MediaActive, not recruitingNCT00270660Phase 3
2Great Auricular Nerve Block for Tympanomastoid Surgery: Will the Addition of Clonidine Enhance the Duration of Analgesia?CompletedNCT01638052Phase 2
3Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in ChildrenCompletedNCT00682409
4Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
5Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
6Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
7Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma


Cochrane evidence based reviews: cholesteatoma

Genetic Tests for Cholesteatoma

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Anatomical Context for Cholesteatoma

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MalaCards organs/tissues related to Cholesteatoma:

33
Brain, Bone, Skin, Lung, Breast, Liver, Testes

FMA organs/tissues related to Cholesteatoma:

16
Middle ear

Animal Models for Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.1FGF7, IL1A, KRT14, KRT16, MMP9, TGFA
2MP:00053827.1KRT14, KRT16, MMP2, TGFA, TNF, TNFRSF11B
3MP:00053876.3FGF7, IL1A, KRT14, MMP2, MMP9, TGFA

Publications for Cholesteatoma

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Articles related to Cholesteatoma:

(show top 50)    (show all 823)
idTitleAuthorsYear
1
Atrial tachyarrhythmias after atrial switch operation for transposition of the great arteries: Treating old surgery with new catheters. (27018378)
2016
2
Phenotypic and imaging features of FLNA-negative patients with bilateral periventricular nodular heterotopia and epilepsy. (26340046)
2015
3
Characterization of DNA binding and pairing activities associated with the native SFPQA^NONO DNA repair protein complex. (25998385)
2015
4
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. (25168798)
2014
5
Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production. (24816316)
2014
6
Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. (24019980)
2013
7
A 2-year-old girl with co-inherited cystic fibrosis and sickle cell-I^+ thalassemia presenting with recurrent vaso-occlusive events during cystic fibrosis pulmonary exacerbations: a case report. (23890029)
2013
8
Spinal deformities and Lung Function in Adults with Osteogenesis Imperfecta. (24308436)
2013
9
The eye-tracking computer device for communication in amyotrophic lateral sclerosis. (24350578)
2013
10
Urologic complications of genitourinary schistosomiasis. (21909645)
2012
11
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
12
Cerebral toxoplasmosis: unusual MRI findings. (22920346)
2012
13
Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. (22625427)
2012
14
Assessment of developmental coordination disorder in children born with extremely low birth weights. (21253990)
2011
15
Overexpression of carbonic anhydrase and HIF-1I+ in Wilms tumours. (21910893)
2011
16
Expression of stromal derived factor-1 (SDF-1) and chemokine receptor (CXCR4) in bone metastasis of renal carcinoma. (20563655)
2011
17
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells. (20187777)
2010
18
UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo. (19794410)
2010
19
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. (19101114)
2009
20
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
21
Tacrolimus population pharmacokinetic-pharmacogenetic analysis and Bayesian estimation in renal transplant recipients. (19902988)
2009
22
Role of aldosterone and angiotensin II in insulin resistance: an update. (19138313)
2009
23
Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. (18514010)
2008
24
A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 integrins in a bent, resting conformation. (18841997)
2008
25
Factor XI in haemostasis and thrombosis: past, present and future. (17597996)
2007
26
Molecular epidemiology and urothelial cancer. (17900006)
2007
27
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
28
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice. (15863313)
2005
29
Sulphatase activities are regulated by the interaction of sulphatase- modifying factor 1 with SUMF2. (15962010)
2005
30
Bilateral benign haemorrhagic adrenal cysts in Beckwith-Wiedemann syndrome: case report. (15080519)
2004
31
Usefulness of cardiac transplantation in children with visceral heterotaxy (asplenic and polysplenic syndromes and single right-sided spleen with levocardia) and comparison of results with cardiac transplantation in children with dilated cardiomyopathy. (12031727)
2002
32
Diacylglycerol kinases: regulation and signaling roles. (12529738)
2002
33
Analysis of the mutational spectrum of the FGFR2 gene in Pfeiffer syndrome. (10394936)
1999
34
Apoptosis versus proliferation activities and relative mechanism in chronic obstructive pulmonary disease]. (11038804)
1998
35
Where you go depends on where you are. Early investigations on the use of deoxycorticosterone in Addison's disease: a historical vignette. (9589633)
1998
36
Etiology of positional plagiocephaly in triplets and treatment using a dynamic orthotic cranioplasty device. Report of three cases. (15096018)
1997
37
Nephrotic syndrome and concurrent infectious mononucleosis. (9090679)
1997
38
Spinal cord neurons in which interaction between N-methyl-D-aspartate and neurokinin-1 receptors may occur. (9044367)
1996
39
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
40
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. (7519852)
1994
41
Tetanus as a cause of acute renal failure: possible role of rhabdomyolysis. (8115681)
1993
42
Oligodendrocytes lack glycolipid anchored proteins which protect them against complement lysis. Restoration of resistance to lysis by incorporation of CD59. (1378423)
1992
43
Anticardiolipin antibodies and pregnancy outcome in women with human immunodeficiency virus infection. (1603506)
1992
44
Description of a polymorphism in the regulatory region of the HLA-DRA gene. (1685491)
1991
45
Interactions between estrogens, androgens, progestins, and glucocorticoids in ZR-75-1 human breast cancer cells. (2142871)
1990
46
Modelling assembled spelling: convergence of data from normal subjects and "surface" dysgraphia. (3416615)
1988
47
Toward early diagnosis of myotonic dystrophy: construction and characterization of a somatic cell hybrid with a single human der(19) chromosome. (3502690)
1986
48
Elephantiasis nostras verrucosa. (7356700)
1980
49
Vaginal discharge and sexually transmitted diseases. (108216)
1978
50
A case of spino-cerebellar degeneration associated with carcinoma of the prostate. (6021237)
1967

Variations for Cholesteatoma

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Expression for genes affiliated with Cholesteatoma

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Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

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GO Terms for genes affiliated with Cholesteatoma

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Cellular components related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.9KRT13, KRT14

Biological processes related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1A, TNF
2embryo implantationGO:000756610.0MMP2, MMP9
3osteoclast differentiationGO:00303169.9TNF, TNFSF11
4regulation of osteoclast differentiationGO:00456709.9TNF, TNFSF11
5positive regulation of osteoclast differentiationGO:00456729.8TNF, TNFSF11
6immune responseGO:00069558.5DEFB1, IL1A, TNF, TNFRSF11B, TNFSF11

Sources for Cholesteatoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet