MCID: CHL069
MIFTS: 58

Cholesteatoma malady

Summaries for Cholesteatoma

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Cholesteatoma is a type of skin cyst located in the middle ear. it can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. the hallmark symptom is a painless discharge from the ear.hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. surgery can stop infections and prevent complications.   last updated: 12/30/2009

MalaCards: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to middle ear cholesteatoma and otitis media. An important gene associated with Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Rheumatoid arthritis and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are craniofacial and integument.

Wikipedia:63 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Aliases & Classifications for Cholesteatoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

cholesteatoma 8 42 10 44 60
secondary acquired cholesteatoma 42
primary acquired cholesteatoma 42
cholesteatoma, unspecified 8
congenital cholesteatoma 42


External Ids:

Disease Ontology8 DOID:869
ICD9CM27 385.30
NCIt39 C2944
MeSH34 D002781

Related Diseases for Cholesteatoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1middle ear cholesteatoma31.6S100A8, TGFA, KRT13, TNFSF11, IVL, DEFB4A
2otitis media31.1DEFB1
3keratosis30.1FLG, IVL, KRT16, KRT10
4cleft palate30.1FGFR2, TGFA
5squamous cell carcinoma30.0LGALS1, LGALS8, TGFA
6cleft lip29.8TGFA
7congenital ichthyosiform erythroderma29.8FLG, IVL, KRT10
8craniopharyngioma29.8LGALS1
9suppurative otitis media10.6
10cholesteatoma of attic10.5
11cholesteatoma of external ear10.4
12maxillary sinus cholesteatoma10.3
13facial paralysis10.2
14labyrinthitis10.2
15tympanosclerosis10.2
16intracranial abscess10.0
17sensorineural hearing loss10.0
18purulent labyrinthitis10.0
19lateral sinus thrombosis10.0
20fibrous dysplasia10.0
21cervicitis10.0
22chronic meningitis10.0
23meningitis10.0
24middle ear carcinoma10.0
25middle ear disease10.0
26skin disease10.0IL1A, MMP9
27leukoplakia10.0KRT13, DEFB4A, IVL, FLG
28lichen planus10.0FLG, IVL, DEFB4A, KRT16, KRT13, KRT10
29psoriasis10.0S100A8, FLG, IVL, DEFB4A, FGF7, IL1A
30keratoacanthoma10.0IVL, KRT10
31esophagitis10.0S100A8
32periodontitis10.0TNFRSF11B, IL1A, MMP9
33duodenal ulcer10.0S100A8, DEFB1, DEFB4A
34periodontal disease10.0MMP1, TNFSF11
35dermatitis10.0FLG, IVL, IL1A, KRT16
36gingivitis10.0TNFSF11, TNFRSF11B, IL1A, MMP1
37nonepidermolytic palmoplantar keratoderma10.0TGFA, KRT10, KRT16, DEFB4A, FLG
38sarcoma10.0FGF7, LGALS1
39primary hyperoxaluria10.0TNFRSF11B
40cystic fibrosis10.0S100A8, TNFRSF11B, DEFB1, DEFB4A, FGF7, KRT13
41adenocarcinoma10.0S100A8, TNFSF11, IVL, FGFR2, FGF7, MMP9
42duodenitis10.0S100A8
43adenoma10.0TGFA, LGALS1, KRT13, S100A8
44epidermolysis bullosa10.0FLG
45pneumonia10.0FGF7, DEFB4A, DEFB1, S100A8
46asthma10.0S100A8, FLG, DEFB1, DEFB4A, CHKB, MMP9
47bowen syndrome10.0KRT10, KRT16, IVL, FLG
48synovitis10.0TNFSF11, TNFRSF11B, IL1A, MMP1
49hepatocellular carcinoma10.0S100A8, TNFSF11, FGFR2, FGF2, MMP9, KRT13
50clear cell acanthoma10.0IVL

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Clinical Features for Cholesteatoma

About this section

Drugs & Therapeutics for Cholesteatoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cholesteatoma

Drug clinical trials:

Search ClinicalTrials for Cholesteatoma

Search NIH Clinical Center for Cholesteatoma

Search CenterWatch for Cholesteatoma

Genetic Tests for Cholesteatoma

About this section

Anatomical Context for Cholesteatoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cholesteatoma:

32
Bone, Skin, Brain, Endothelial, Placenta, Monocytes, Temporal lobe

Animal Models for Cholesteatoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cholesteatoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538210.6TGFA, TNFSF11, TNFRSF11B, FLG, FGFR2, KRT16
2MP:001077110.5TNFSF11, FGFR2, MMP9, KRT16, LGALS1, TGFA
3MP:000537710.5KRT10, FLG, TNFRSF11B
4MP:000538710.4TNFSF11, TNFRSF11B, FLG, DEFB1, FGFR2, FGF7
5MP:001076810.3FLG, TNFRSF11B, TNFSF11, S100A8, DEFB1, FGFR2
6MP:000539010.1TNFSF11, TNFRSF11B, CHKB, FGFR2, FGF2, TGFA

Publications for Cholesteatoma

About this section
Sources:
50PubMed
See all sources

Articles related to Cholesteatoma:

(show top 50)    (show all 733)
idTitleAuthorsYear
1
Cathelicidin Antimicrobial Peptide LL-37 in Cholesteatoma Enables Keratinocyte Reactivity with Cytosolic DNA. (24383796)
2014
2
Possible participation of acidic pH in bone resorption in middle ear cholesteatoma. (24122656)
2014
3
Letter to the Editor regarding 'Pie-slice tympanoplasty for transcanal removal of small congenital cholesteatoma'. (23415070)
2013
4
Evaluation of temporal bone cholesteatoma and the correlation between high resolution computed tomography and surgical finding. (24179410)
2013
5
Current trends in the management of the complications of chronic otitis media with cholesteatoma. (23892792)
2013
6
Does diffusion-weighted MRI (DW-MRI) change treatment strategy in pediatric cholesteatoma? (23130592)
2013
7
Use of mastoid obliteration techniques in cholesteatoma. (23872728)
2013
8
Ossicular erosion in patients requiring surgery for cholesteatoma. (24303397)
2012
9
Aural cholesteatoma with upper neck extension. (22115754)
2012
10
Stage progression of congenital cholesteatoma in children. (21898088)
2012
11
Detection of recurrent and primary acquired cholesteatoma with echo-planar diffusion-weighted magnetic resonance imaging. (22583684)
2012
12
Clinical characteristics and surgical benefits and problems of chronic otitis media and middle ear cholesteatoma in elderly patients older than 70 years. (22801042)
2012
13
Risk factors for deterioration of bone conduction hearing in cases of labyrinthine fistula caused by middle ear cholesteatoma. (22530475)
2012
14
Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion. (22481617)
2012
15
Coexisting middle ear cholesteatoma and giant petrous apex cholesterol granuloma. (22193616)
2012
16
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
17
Cholesteatoma imaging using modified echo-planar diffusion-weighted magnetic resonance imaging. (20831846)
2011
18
Congenital primary cholesteatoma of external auditory canal. (20667625)
2011
19
How do we know it is really congenital cholesteatoma? (21254957)
2011
20
Exclusive endoscopic ear surgery for acquired cholesteatoma: preliminary results. (21206389)
2011
21
Prognostic indicators of hearing after complete resection of cholesteatoma causing a labyrinthine fistula. (21387189)
2011
22
Management of complex cases of petrous bone cholesteatoma. (20860276)
2010
23
Imaging findings in a case with cholesteatoma in complete aural atresia. (20015763)
2010
24
The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media. (20887552)
2010
25
Extensive external auditory canal cholesteatoma in the infratemporal area without mastoid involvement: use of a new surgical technique. (20859869)
2010
26
Childhood cholesteatoma. (20860924)
2010
27
Can cochlear function be preserved after a modified translabyrinthine approach to eradicate a huge cholesteatoma extending to the petrous apex? (19034472)
2009
28
Lateral sinus thrombosis and brain abscess as a complication of cholesteatoma. (19488579)
2009
29
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (18419858)
2008
30
The structure of acquired aural cholesteatoma as revealed by scanning electron microscopy. (18335406)
2008
31
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
32
Expression and significance of nuclear factor-kappa B ligand and correlation factor in the tissue of otitis media with cholesteatoma]. (17580719)
2007
33
Comparative analysis of the epithelium stroma interaction of acquired middle ear cholesteatoma in children and adults. (17541620)
2007
34
Non-classical presentation of congenital cholesteatoma. (17346390)
2007
35
Cholesteatoma, cerebrospinal fluid leakage, and chronic otitis media. (16988616)
2006
36
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
37
Cholesteatoma of the clivus. (16880901)
2006
38
Long-term results with operated sinus tympani retraction cholesteatoma. (16815202)
2006
39
Morphological considerations about middle ear cholesteatoma. (16838062)
2006
40
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
41
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
42
Expression of epidermal growth factor, tumor necrosis factor-alpha, and interleukin-1alpha in chronic otitis media with or without cholesteatoma. (12218613)
2002
43
Differentiation characteristics of cholesteatoma epithelium determined by expression of transglutaminase isoenzymes. (10642946)
1999
44
Lateral sinus thrombosis and cervical abscess complicating cholesteatoma in children: case report and review. (9466230)
1998
45
Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in middle ear cholesteatoma: an analysis of protein production and biological activity. (8737779)
1996
46
Residue of middle ear cholesteatoma after intact canal wall tympanoplasty: surgical findings at one year. (8712631)
1996
47
Identification of proliferating keratinocytes in middle ear cholesteatoma using the monoclonal antibody Ki-67. (8718533)
1996
48
Hyperproliferation-associated keratin expression in human middle ear cholesteatoma. (7685977)
1993
49
Surgical treatment of middle ear cholesteatoma. (3604791)
1987
50
Etiology of a middle ear cholesteatoma, Kodachrome study of pathogenesis. (5724411)
1968

Genetic Variations for Cholesteatoma

About this section

Expression for genes affiliated with Cholesteatoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cholesteatoma

Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

About this section
Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Cholesteatoma according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5TNFSF11
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5TNFSF11, TNFRSF11B, IL1A
310.5TNFRSF11B, TNFSF11
4
Hide members
10.5IL1A, FGFR2
510.5MMP9, FGF2, FGFR2
610.5IVL, MMP1, MMP9
7
Hide members
10.5FGFR2, FGF7, IL1A
8
Hide members
10.5IL1A, FGF2, FGF7, FGFR2, DEFB4A, DEFB1
910.5FGFR2, FGF2, MMP9, TGFA
10
Hide members
10.5MMP9, FGF2, FGF7, FGFR2
11
Hide members
10.4FGFR2, FGF7, FGF2
12
Hide members
10.4FGFR2, FGF7, FGF2
13
Hide members
10.4TNFSF11, FGFR2, FGF7, FGF2, IL1A, TGFA
14
Hide members
10.4TNFSF11, FGFR2, FGF7, FGF2, IL1A, TGFA
15
Hide members
10.4TGFA, IL1A, FGF2, FGF7, FGFR2
16
Hide members
10.4FGFR2, FGF7, FGF2, MMP1, MMP9, TGFA
17
Hide members
10.4TGFA, MMP9, MMP1, FGF2, FGF7, FGFR2
1810.4TGFA, MMP9, MMP1, FGF2, FGF7, FGFR2

Compounds for genes affiliated with Cholesteatoma

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Cholesteatoma according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9IVL, CHKB, DEFB4A
2pge24410.9MMP9
3dexamethasone44 49 28 1113.9DEFB4A, FGF2, MMP9, LGALS1, TNFRSF11B, DEFB1
4rantes4410.9FGF7, DEFB4A, S100A8, IL1A
5vitamin d4410.9TNFSF11, FGFR2, IVL, CHKB, TGFA, FGF7
6calcitriol44 59 11 2413.9KRT10, KRT16, MMP1, IL1A, FGF2, IVL
7paraffin4410.9TGFA, S100A8, TNFSF11, IVL, DEFB4A, CHKB
8ns 39844 5911.9MMP9, FGF2, IL1A, MMP1, TNFRSF11B, TNFSF11
9genistein44 28 59 2 11 2415.9DEFB4A, FGFR2, FGF7, FGF2, IL1A, MMP1
10serine4410.9S100A8, TNFSF11, FGF2, TNFRSF11B, FLG, IVL
11dithranol4410.9FLG, KRT10, KRT16, IVL, TGFA
12heparin44 28 11 2413.9LGALS1, IL1A, FGF7, TNFSF11, TNFRSF11B, DEFB4A
13retinoic acid44 2411.9S100A8, TNFRSF11B, FLG, FGF2, IVL, DEFB1
14steroid4410.9FLG, TNFSF11, TGFA, KRT10, FGF7, FGFR2
15cyclosporin a44 28 5912.9FGF2, TNFRSF11B, IVL, CHKB, TGFA, FGF7
161,25 dihydroxy vitamin d34410.8TNFSF11, FGF7, KRT10, KRT16, IVL, TNFRSF11B
17cysteine4410.8TNFSF11, TGFA, MMP9, MMP1, FLG, FGF7
18heparan sulfate44 2411.8TNFSF11, TNFRSF11B, IVL, DEFB1, FGFR2, FGF2
19calcipotriol44 59 28 1113.8KRT10, FLG, IVL, IL1A, KRT16
20pd 98,0594410.8FGF2, IVL, TGFA, TNFSF11, MMP9, MMP1
21methotrexate44 49 1112.8TGFA, S100A8, TNFRSF11B, IVL, CHKB, MMP1
22sb 20358044 5911.8TNFSF11, IL1A, MMP9, TNFRSF11B, MMP1, FGF2
23ascorbic acid44 2411.8IL1A, TNFRSF11B, FLG, FGF2, TGFA, TNFSF11
24vegf4410.8FGF2, IL1A, TGFA, IVL, TNFRSF11B, TNFSF11
25procollagen4410.8TNFSF11
26hydrocortisone44 2 59 1113.8MMP1, IVL, TNFRSF11B, TGFA, FGF7, IL1A
27bromodeoxyuridine4410.8TGFA, KRT10, FGF2, FGF7, FGFR2, IVL
28celecoxib44 59 28 49 11 2415.8FGF7, TNFRSF11B, FGF2, MMP1, MMP9, TNFSF11
29calcium44 49 11 2413.8CHKB, S100A8, TNFSF11, TNFRSF11B, FLG, IVL
30glycosaminoglycan4410.8IL1A, MMP9, FGF2, FGF7, MMP1, FGFR2
31tyrosine4410.8FGF7, FGFR2, S100A8, TNFSF11, DEFB4A, IVL
32testosterone44 59 11 2413.8TNFSF11, TGFA, MMP1, MMP9, TNFRSF11B, IL1A
33agar4410.7LGALS1, TGFA, FGF2, FGF7, FGFR2, CHKB
34retinoid4410.7IVL, MMP1, LGALS1, S100A8, KRT10, KRT16
35gf 109203x44 5911.7IVL, FGF2, FLG, MMP1, KRT10, TGFA
36urea44 11 2412.7CHKB, FLG, S100A8, TNFRSF11B, TNFSF11, IVL
37infliximab44 49 1112.7MMP1, FGF2, FLG, TNFRSF11B, TNFSF11
3812-o-tetradecanoylphorbol 13-acetate4410.7MMP1, FGFR2, IVL, TGFA, MMP9, IL1A
39creatinine4410.7TNFSF11, MMP9, MMP1, IL1A, CHKB, TNFRSF11B
40polysaccharide4410.7IVL, LGALS1, TGFA, FGFR2, CHKB, FGF2
41tgf beta14410.7FGF2, MMP1, TNFRSF11B, FGF7, TGFA, MMP9
42nitric oxide44 11 2412.6KRT16, TNFRSF11B, IL1A, CHKB, S100A8, FLG
43phosphatidylinositol4410.6TNFSF11, TGFA, LGALS8, MMP9, FGF7, FGF2
44doxycycline44 1111.6MMP1, TNFSF11, FGF7
45rapamycin4410.5MMP1, TNFSF11, FGF7, IL1A, LGALS1, TGFA
46cycloheximide4410.5FGF7
47hematoxylin4410.5KRT10, MMP1, IVL
48progesterone44 59 28 11 2414.4FGF7, FGFR2, TNFRSF11B, TGFA, KRT10, MMP1
49nicotine44 49 28 1113.4MMP1, MMP9, IL1A, FGF2, IVL, FLG
50prostaglandin4410.2TNFRSF11B, IL1A, MMP1, TNFSF11, MMP9, TGFA

GO Terms for genes affiliated with Cholesteatoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.5KRT10, KRT16, FLG
2extracellular regionGO:00557610.4MMP9, S100A8, TNFSF11, TNFRSF11B, DEFB1, DEFB4A
3extracellular spaceGO:00561510.3S100A8, TNFSF11, TNFRSF11B, FGF2, IL1A, MMP9
4proteinaceous extracellular matrixGO:00557810.2TNFRSF11B, MMP1, MMP9, LGALS1

Biological processes related to Cholesteatoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma cell differentiationGO:00231710.7LGALS1, LGALS8
2positive regulation of cell divisionGO:05178110.7TGFA, IL1A, FGF2, FGF7, FGFR2
3innate immune responseGO:04508710.7S100A8, DEFB1, DEFB4A, FGFR2, FGF7, FGF2
4positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:06050110.7FGF7, FGFR2
5positive regulation of keratinocyte migrationGO:05154910.7MMP9, FGF7
6epidermal growth factor receptor signaling pathwayGO:00717310.6FGFR2, FGF7, FGF2, TGFA
7positive regulation of epithelial cell proliferationGO:05067910.6FGFR2, FGF7, TGFA
8keratinocyte differentiationGO:03021610.6FLG, IVL, KRT10
9wound healingGO:04206010.5S100A8, FGF2, TGFA
10epidermis developmentGO:00854410.5KRT13, KRT16, FGF7
11branching involved in salivary gland morphogenesisGO:06044510.5FGF7, FGFR2
12extracellular matrix organizationGO:03019810.4TNFRSF11B, FGF2, MMP1, MMP9
13organ morphogenesisGO:00988710.2FGF2, FGFR2, TNFSF11

Molecular functions related to Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.5IL1A, FGF2, TNFRSF11B, TNFSF11

Products for genes affiliated with Cholesteatoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cholesteatoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet