MCID: CHL069
MIFTS: 53

Cholesteatoma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cholesteatoma

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Aliases & Descriptions for Cholesteatoma:

Name: Cholesteatoma 10 45 47 12 36 65
Secondary Acquired Cholesteatoma 45
 
Primary Acquired Cholesteatoma 45
Congenital Cholesteatoma 45

Classifications:



External Ids:

Disease Ontology10 DOID:869
ICD1027 H71.9, H71.90
ICD9CM29 385.30
MeSH36 D002781
NCIt42 C2944
UMLS65 C0008373

Summaries for Cholesteatoma

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NIH Rare Diseases:45 Cholesteatoma is a type of skin cyst located in the middle ear. it can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. the hallmark symptom is a painless discharge from the ear.hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. surgery can stop infections and prevent complications.   last updated: 12/30/2009

MalaCards based summary: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to cholesteatoma of middle ear and cholesteatoma of external ear, and has symptoms including paraesthesia ear, itching of ear and ear congestion. An important gene associated with Cholesteatoma is LGALS8 (Lectin, Galactoside Binding Soluble 8), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. Affiliated tissues include middle ear, bone and skin, and related mouse phenotypes are integument and craniofacial.

Disease Ontology:10 A keratosis characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.

Wikipedia:68 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma

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Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma of middle ear12.4
2cholesteatoma of external ear12.2
3maxillary sinus cholesteatoma12.2
4cholesteatoma of attic12.0
5anatomical narrow angle borderline glaucoma10.7IL1A, MMP9
6sclerosteosis 110.6KRT10, KRT16
7liver cirrhosis10.6IL1A, KRT13
8otitis media10.5
9pilar sheath acanthoma10.5KRT10, KRT14
10factitious disorder10.5KRT10, KRT16, MMP9
11nodular basal cell carcinoma10.5KRT10, KRT14
12skin pilomatrix carcinoma10.4KRT10, KRT14
13nasal cavity squamous cell carcinoma10.4KRT10, KRT14
14mastoiditis10.4
15skin disease10.4IL1A, TNF
16hemorrhagic fever10.4TNFRSF11B, TNFSF11
17paget disease of bone 2, early-onset10.4TNFRSF11B, TNFSF11
18degenerative myopia10.4TNFRSF11B, TNFSF11
19tibial hemimelia10.4TNFRSF11B, TNFSF11
20polycystic bone disease10.4TNFRSF11B, TNFSF11
21suppurative otitis media10.4
22lujo hemorrhagic fever10.3IL1A, TNF
23skin squamous cell carcinoma10.3KRT10, KRT16, MKI67
24duodenal somatostatinoma10.3MMP9, TNF
25perineurioma10.3KRT10, KRT13, KRT14
26intrahepatic biliary papillomatosis10.3TNFRSF11B, TNFSF11
27retinitis pigmentosa 3010.3KRT10, KRT14, KRT16
28leri pleonosteosis10.3MMP2, MMP9
29talo-patello-scaphoid osteolysis10.3MMP2, MMP9
30precursor b lymphoblastic lymphoma/leukemia10.3IL1A, TNF
31entropion10.2MMP2, MMP9
32mixed extragonadal germ cell cancer10.2MMP2, MMP9
33renal pelvis adenocarcinoma10.2MMP2, MMP9
34ovarian clear cell adenocarcinoma10.2KRT14, MKI67
35ganglion or cyst of synovium/tendon/bursa10.2MMP2, MMP9
36spastic diplegia10.2IL1A, KRT13, MMP9, TNFSF11
37ehlers-danlos syndrome10.2MMP2, MMP9
38funisitis10.2IL1A, MMP9, TNF
39periodic limb movement disorder10.2KRT10, KRT13, TNF
40granulomatous orchitis10.2IL1A, MMP9, TNF
41mucocele of appendix10.2TNFRSF11B, TNFSF11
42contact dermatitis10.2IL1A, KRT16, TNF
43asphyxiating thoracic dystrophy10.2MMP9, TGFA, TNF
44mononeuritis of upper limb10.2MMP9, TNFRSF11B, TNFSF11
45vulva verrucous carcinoma10.2KRT10, MMP9
46intrahepatic cholangiocarcinoma10.2MMP2, MMP9
47long bone adamantinoma10.2IL1A, KRT16, TNF
48parotid disease10.2MMP2, MMP9
49gastric squamous cell carcinoma10.1MMP2, MMP9
50renal fibrosis10.1KRT10, KRT14

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Symptoms for Cholesteatoma

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UMLS symptoms related to Cholesteatoma:


paraesthesia ear, itching of ear, ear congestion, auricular swelling, erythematous ear canal, earache

Drugs & Therapeutics for Cholesteatoma

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Drugs for Cholesteatoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ClonidineapprovedPhase 21894205-90-72803
Synonyms:
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI)
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
2,6-dichloro-N-(2-imidazolidinylidene)aniline
2,6-dichloro-N-2-imidazolidinylidenebenzenamide
2,6-dichloro-N-imidazolidin-2-ylideneaniline
2-((2,6-Dichlorophenyl)imino)imidazolidine
2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
2-(2,6-Dichloroanilino)-2-imidazoline
2-(2,6-Dichlorophenylamino)-2-imidazoline
2-(2,6-Dichlorophenylimino)imidazolidine
2-Imidazoline, 2-(2,6-dichloroanilino)- (7CI,8CI)
2-[(2,6-Dichlorophenyl)imino]imidazoline
2-[(2,6-dichlorophenyl)imino]-2-imidazoline
4205-90-7
4205-91-8 (mono-hydrochloride)
57066-25-8
734571A
AB00514634
AC1L1EI5
AC1Q3K6V
AKOS001595470
Adesipress
BIDD:GT0547
BPBio1_000040
BRD-K98530306-001-02-1
BRD-K98530306-003-05-0
BSPBio_000036
BSPBio_001588
BSPBio_002055
Bio1_000470
Bio1_000959
Bio1_001448
Bio2_000308
Bio2_000788
C9H9Cl2N3
CAS-4205-91-8
CATAPRES-TTS-1
CATAPRES-TTS-2
CATAPRES-TTS-3
CCRIS 7787
CHEBI:3757
CHEBI:46632
CHEMBL134
CID2803
Catapres
Catapres- TTS
Catapres-TTS
Catapresan
Catapressan
Catarpres
Catarpres-TTS
Catarpres-TTS (TN)
Catarpresan
Chlofazoline
Chlornidinum
Clofenil
Clonidin
Clonidina
Clonidina [INN-Spanish]
Clonidine
Clonidine (JAN/USAN/INN)
Clonidine HCl
Clonidine Hydrochloride
Clonidine Transdermal System
Clonidine [USAN:BAN:INN]
Clonidinhydrochlorid
Clonidinum
Clonidinum [INN-Latin]
Clonistada
Clopheline
D00281
DB00575
DB07566
DivK1c_000774
 
Dixarit
Duraclon
Duraclont
EINECS 224-119-4
Gemiton
HMS1361P10
HMS1791P10
HMS1989P10
HMS2089G11
HSDB 3040
Hemiton
IDI1_000774
IDI1_034058
Ipotensium
Isoglaucon
KBio1_000774
KBio2_000308
KBio2_001821
KBio2_002876
KBio2_004389
KBio2_005444
KBio2_006957
KBio3_000615
KBio3_000616
KBio3_001275
KBioGR_000308
KBioGR_001572
KBioSS_000308
KBioSS_001821
Kapvay
Klofelin
Klofenil
L000193
LS-79606
Lopac-C-7897
Lopac0_000268
M 5041T
M-5041T
MolPort-001-779-668
MolPort-005-932-374
N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
NCGC00015268-01
NCGC00015268-02
NCGC00015268-08
NCGC00024734-01
NCGC00024734-02
NCGC00024734-03
NCGC00024734-04
NCGC00024734-05
NCGC00179680-01
NINDS_000774
Nexiclon
Nexiclon Xr
Prestwick0_000248
Prestwick1_000248
Prestwick2_000248
Prestwick3_000248
SKF 34427
SPBio_001233
SPBio_002255
ST 155BS
ST-155-BS
ST-155BS
Spectrum2_001187
Spectrum3_000358
Spectrum4_000956
Spectrum5_000759
Spectrum_001341
T171
Tenso-Timelets
Tocris-0690
UNII-MN3L5RMN02
ZINC00896484
clonidine
nchembio.79-comp11
nchembio705-10
2
Bupivacaineapproved, investigationalPhase 29642180-92-92474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Hydrochloride
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
DepoBupivacaine
 
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
Exparel
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
Racemic bupivacaine
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Vivacaine
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
3Central Nervous System DepressantsPhase 210016
4Neurotransmitter AgentsPhase 214795
5Peripheral Nervous System AgentsPhase 218510
6Antihypertensive AgentsPhase 23618
7Anesthetics, LocalPhase 22347
8Adrenergic alpha-2 Receptor AgonistsPhase 2790
9Adrenergic AgonistsPhase 22331
10Adrenergic alpha-AgonistsPhase 21300
11AnalgesicsPhase 29358
12AnestheticsPhase 27385
13Adrenergic AgentsPhase 24204

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis MediaActive, not recruitingNCT00270660Phase 3
2Great Auricular Nerve Block for Tympanomastoid Surgery: Will the Addition of Clonidine Enhance the Duration of Analgesia?CompletedNCT01638052Phase 2
3Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in ChildrenCompletedNCT00682409
4Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
5Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
6Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
7Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma


Cochrane evidence based reviews: cholesteatoma

Genetic Tests for Cholesteatoma

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Anatomical Context for Cholesteatoma

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MalaCards organs/tissues related to Cholesteatoma:

33
Bone, Skin, Brain, Lung, Prostate, Breast, Heart

FMA organs/tissues related to Cholesteatoma:

16
Middle ear

Animal Models for Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.1FGF7, IL1A, KRT14, KRT16, MMP9, TGFA
2MP:00053827.1KRT14, KRT16, MMP2, TGFA, TNF, TNFRSF11B
3MP:00053876.3FGF7, IL1A, KRT14, MMP2, MMP9, TGFA

Publications for Cholesteatoma

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Articles related to Cholesteatoma:

(show top 50)    (show all 848)
idTitleAuthorsYear
1
Updates and Knowledge Gaps in Cholesteatoma Research. (25866816)
2015
2
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
3
Long-term surgical and functional outcomes of the intact canal wall technique for middle ear cholesteatoma in the paediatric population. (25709151)
2014
4
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
5
Health-related quality of life measurement after cholesteatoma surgery: comparison of three different surgical techniques. (25359196)
2014
6
Recurrent aseptic meningitis as a rare but important presentation of congenital petrous apex cholesteatoma: the value of appropriate imaging. (24614768)
2014
7
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
8
Congenital cholesteatoma in identical twins. (23217274)
2013
9
Letter to the Editor regarding 'Pie-slice tympanoplasty for transcanal removal of small congenital cholesteatoma'. (23415070)
2013
10
Differential gene expression in cholesteatoma by DNA chip analysis. (23670528)
2013
11
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
12
Congenital cholesteatoma of the infratemporal fossa with congenital aural atresia and mastoiditis: a case report. (22731118)
2012
13
Petrous bone cholesteatoma removed by trans-superior semicircular canal approach: long-term hearing results in three cases. (22770523)
2012
14
HASTE diffusion-weighted MRI for the reliable detection of cholesteatoma. (21960134)
2012
15
How long is long enough to follow up children after cholesteatoma surgery? A 29-year study. (23108885)
2012
16
Ossicular erosion in patients requiring surgery for cholesteatoma. (24303397)
2012
17
Cholesteatoma growth and proliferation: relevance with serpin B3. (23239141)
2012
18
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
19
Acquired cholesteatoma: classification and outcomes. (21725267)
2011
20
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
21
Petrous bone cholesteatoma: classification, management and review of the literature. (20668373)
2011
22
Transcanal endoscopic management of cholesteatoma. (20418796)
2010
23
Congenital middle ear cholesteatoma. (21086268)
2010
24
Osteoplastic atticoantrotomy with autologous bone chips and a bony attic strut in cholesteatoma surgery. (19953260)
2010
25
Mastoid subperiosteal abscess as a first sign of unnoticed cholesteatoma in children. (19814752)
2010
26
Tympanic membrane cholesteatoma: a rare finding. (20718191)
2010
27
External auditory canal cholesteatoma: a rare complication of tympanoplasty. (19924662)
2009
28
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
29
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (18419858)
2008
30
Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. (19144300)
2008
31
Residual cholesteatoma: incidence and localization in canal wall down tympanoplasty with soft-wall reconstruction. (18559735)
2008
32
Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl. (19131785)
2008
33
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
34
Applicability of autologous incus: the influence of age and localization of cholesteatoma. (17415579)
2007
35
A new case of synchronous primary external ear canal cholesteatoma. (16730556)
2006
36
The pathophysiology of cholesteatoma. (17097438)
2006
37
Cholesteatoma, cerebrospinal fluid leakage, and chronic otitis media. (16988616)
2006
38
Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture. (15875782)
2005
39
Expression and significance of TERT and c-Myc oncogene protein product on cholesteatoma epithelium]. (16001896)
2005
40
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
41
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
42
Advantages of endoscopically assisted surgery for attic cholesteatoma. (18493554)
2001
43
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
44
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
45
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
46
A study on epidermal proliferation ability in cholesteatoma. (9546266)
1998
47
Clinical and biochemical studies of bone destruction in cholesteatoma. (8763371)
1996
48
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
49
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
50
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990

Variations for Cholesteatoma

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Expression for genes affiliated with Cholesteatoma

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Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

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GO Terms for genes affiliated with Cholesteatoma

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Cellular components related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.9KRT13, KRT14

Biological processes related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1A, TNF
2embryo implantationGO:000756610.0MMP2, MMP9
3osteoclast differentiationGO:00303169.9TNF, TNFSF11
4regulation of osteoclast differentiationGO:00456709.9TNF, TNFSF11
5positive regulation of osteoclast differentiationGO:00456729.8TNF, TNFSF11
6immune responseGO:00069558.5DEFB1, IL1A, TNF, TNFRSF11B, TNFSF11

Sources for Cholesteatoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet