Cholesteatoma malady

NIH Rare Diseases: Cholesteatoma is a type of skin cyst located in the middle ear. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. The hallmark symptom is a painless discharge from the ear. Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. Surgery can stop infections and prevent complications.  ³⁰

MalaCards: Cholesteatoma, also known as cholesteatoma (morphologic abnormality), is related to middle ear cholesteatoma and otitis media. An important gene associated with Cholesteatoma is KRT13 (keratin 13), and among its related pathways are Signal transduction_PTEN pathway and Breast Cancer Regulation by Stathmin1. The compounds threonine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include skin, placenta and monocytes, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in...⁴⁴ more...

Aliases & Descriptions:

cholesteatoma 6 30 8 32 43 cholesteatoma (morphologic abnormality) 6 secondary acquired cholesteatoma (type) 30 primary acquired cholesteatoma (type) 30

congenital cholesteatoma (type) 30 cholesteatoma, unspecified 6 cholesteatoma (disorder) 6

Diseases related to cholesteatoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 907)

id	Related Disease	Score	Top Affiliating Genes
1	middle ear cholesteatoma	37.4	PCNA, CHKB, S100A8, IVL, MMP1, MMP9
2	otitis media	29.5	MUC5AC, LACTB, CEACAM5, ITGAL, MMP2, MMP9
3	craniopharyngioma	26.2	PCNA, RARB, LGALS1, LGALS3, S100A1, S100A2
4	hypoxia	19.1	PDCD4, PCNA, VEGFA, RARA, BIRC5, LGALS1
5	acanthoma	14.0	PCNA, IVL, FGF7, FGFR2, KRT16, KRT1
6	epidermolytic acanthoma	14.0	KRT16, KRT1, KRT10
7	chronic ulcer of skin	14.0	MMP1, MMP8, FGF2, EGF, DEFB4A
8	epidermolysis bullosa simplex	14.0	IVL, FLG, KRT16, KRT1, KRT10, KRT14
9	clear cell acanthoma	14.0	IVL, FGF7, FGFR2
10	epidermolytic hyperkeratosis	14.0	FLG, KRT1, KRT10
11	diabetic foot ulcers	14.0	MMP9, FGF2, KRT16, KRT10, EGF, TGFB1
12	bowen syndrome	14.0	PCNA, IVL, MKI67, FLG, KRT16, KRT1
13	oral candidiasis	14.0	DEFB1, DEFB4A, DEFB103B, SLPI
14	localized scleroderma	13.9	MMP1, TGFB1, DEFB1, DEFB4A, DEFB103B
15	epidermolytic palmoplantar keratoderma	13.9	KRT16, KRT1, KRT14
16	embryonal cancer	13.9	FGF2, EGF, TGFA
17	hereditary mucosal leukokeratosis	13.9	PCNA, RARB, MKI67, KRT1, TGFA
18	epidermolysis bullosa dystrophica	13.9	MMP1, MMP3, FLG
19	aggressive periodontitis	13.9	MMP1, MMP8, IL1A
20	polymorphous low-grade adenocarcinoma	13.9	PCNA, LGALS3, CHKB, S100A1
21	prostatic hypertrophy	13.9	PCNA, LGALS8, FGF2, EGF, EGFR
22	inverted papilloma	13.9	PCNA, MKI67, KRT13
23	ichthyosis vulgaris	13.9	IVL, FLG, SPRR1B, KRT14
24	trichoepithelioma	13.9	IVL, MKI67, KRT10, KRT14
25	abdominal aortic aneurysm	13.9	MMP1, MMP2, MMP3, MMP8, MMP9, TNFRSF11B
26	acrocephalosyndactylia	13.9	FGF2, FGF7, FGFR2
27	periapical granuloma	13.9	MMP8, IL1A, TNF, TNFRSF11B, TNFSF11, NOS2
28	mammary paget's disease	13.9	TNFRSF11B, TNFSF11, KRT14, EGFR
29	multicentric reticulohistiocytosis	13.9	TNF, TNFRSF11B, TNFSF11
30	polyarteritis nodosa	13.9	CHKB, FGF2, IL6, ICAM2
31	skin conditions	13.9	IL1A, IL6, TNF, KRT10
32	congenital ichthyosiform erythroderma	13.9	IVL, FLG, KRT1, KRT10, TGM3
33	adult dermatomyositis	13.9	CHKB, ICAM1, TNF
34	paget disease, juvenile	13.9	TNFRSF11A, TNFRSF11B, TNFSF11
35	polyostotic osteolytic dysplasia, hereditary expansile	13.9	TNFRSF11A, TNFRSF11B, TNFSF11
36	conjunctivochalasis	13.9	MMP1, MMP2, MMP3, MMP9, IL6
37	cardiac sarcoidosis	13.9	S100A8, IL1A, IL1B, TNF
38	pulmonary alveolar proteinosis	13.9	MMP9, IL1B, TNF, DEFB1, DEFB4A, CSF2
39	acute pyelonephritis	13.9	MMP9, MIF, IL1A, IL6, TNF
40	contact dermatitis	13.9	FLG, IL1A, KRT16
41	joint disorders	13.9	MMP3, IL6, TNF, TNFRSF11B, TNFSF11
42	monoclonal gammopathy of undetermined significance	13.9	IL1B, IL6, ICAM1, TNFRSF11B, TNFSF11
43	root resorption	13.8	MMP9, IL1A, IL1B, TNFRSF11A, TNFRSF11B, TNFSF11
44	hemorrhoid	13.8	PATE1, MMP9, NOS2
45	systemic scleroderma	13.8	S100A8, MMP1, MMP3, MIF, IL1A, ICAM1
46	hyper-ige syndrome	13.8	MMP3, MMP8, MMP9, IL6, CSF2
47	candidiasis	13.8	MIF, CASP14, DEFB1, DEFB4A, DEFB103B, CSF2
48	nephropathia epidemica	13.8	IL1A, IL1B, IL6, TNF
49	bladder squamous cell carcinoma	13.8	S100A7, KRT10, KRT14
50	toxic epidermal necrolysis	13.8	CHKB, MMP2, MMP9, TNF, NOS2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cholesteatoma:

²²

MGI Mouse Phenotypes related to cholesteatoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	CTSH, PGF, TRIM71, ICAM2
2	craniofacial phenotype	MP:0005382	10.4	FLG, FGFR2, GJA1, TRIM71, KRT16, KRT10
3	endocrine/exocrine gland phenotype	MP:0005379	10.4	HEXB, GJA1, FGFR2, PDCD4
4	normal phenotype	MP:0002873	9.0	HIF1A, CTSH, TERT, GJA1, FGFR2, FGF2
5	embryogenesis phenotype	MP:0005380	8.9	CSF2, EGFR, CTNNB1, TRIM71, GJB2, MET
6	liver/biliary system phenotype	MP:0005370	8.5	HIF1A, HEXB, EGFR, PTN, TP53, IL6
7	limbs/digits/tail phenotype	MP:0005371	8.5	TNFRSF11B, TNFSF11, PTHLH, CTNNB1, KRT10, EGFR
8	hearing/vestibular/ear phenotype	MP:0005377	8.5	TNFRSF11B, PTN, CTNNB1, NFKB1, KRT10, EGFR
9	pigmentation phenotype	MP:0001186	8.4	KRT14, KRT1, KRT4, RPE65, CTNNB1, PTEN
10	hematopoietic system phenotype	MP:0005397	8.4	MIF, FGF2, FGF7, FGFR2, ICAM2, GJA1
11	renal/urinary system phenotype	MP:0005367	8.3	PTHLH, CTNNB1, EGFR, HEXB, HIF1A, PTEN
12	reproductive system phenotype	MP:0005389	8.0	PDCD4, VEGFA, RARA, RARB, CKS1B, MMP9
13	integument phenotype	MP:0010771	7.4	CDK2, KRT10, KRT14, EGF, EGFR, TGFA
14	adipose tissue phenotype	MP:0005375	7.3	HEXB, TGFA, TGFB1, PRKCA, CSF2, PGF
15	nervous system phenotype	MP:0003631	6.9	TERT, PTEN, PTN, PTHLH, SPP1, CTSD
16	behavior/neurological phenotype	MP:0005386	6.9	PTEN, PTN, PTHLH, SPP1, CTSD, CTNNB1
17	immune system phenotype	MP:0005387	6.8	PDCD4, F8, GJA1, GJB6, TP53, TNF
18	skeleton phenotype	MP:0005390	6.3	TNFRSF11B, TNFSF11, TERT, PTEN, PTHLH, SPP1
19	digestive/alimentary phenotype	MP:0005381	5.9	NFKB1, NOS2, CTNNB1, CTSD, PTHLH, KRT4
20	vision/eye phenotype	MP:0005391	5.7	VEGFA, GJB2, TP53, TNF, PTEN, PTHLH
21	tumorigenesis	MP:0002006	5.6	MMP9, MIF, FGF2, FGFR2, MET, IL1A
22	mortality/aging	MP:0010768	5.4	MAPK1, F8, GJA1, TRIM71, TP53, TNFRSF11A
23	muscle phenotype	MP:0005369	5.4	VEGFA, RARA, RARB, LGALS1, CHKB, S100A1
24	growth/size phenotype	MP:0005378	4.7	RARA, RARB, CKS1B, JUN, CDKN1A, CDK2
25	cardiovascular system phenotype	MP:0005385	4.1	MET, PTEN, PTHLH, SPP1, CTNNB1, NOS2
26	cellular phenotype	MP:0005384	3.2	PTEN, HGF, SLC3A2, SLPI, PTN, PTHLH
27	homeostasis/metabolism phenotype	MP:0005376	2.2	CASP14, RPE65, NFKB1, KRT16, KRT1, KRT14

Articles related to cholesteatoma:

(show top 50)    (show all 130)

id	Title	Authors	Year	Affiliating Genes
1	Activation of nuclear factor-kappaB and aberrant gen e expression of interleukin 6 in middle ear cholesteatoma (19558856)	Xu Y.... Chen S.M.	2009	NFKB1, IL6
2	Hexosoaminidase gene expression in cholesteatoma in adults (20198983)	Rutkowska J.... Rogowski M.	2009	HEXB
3	Cholesteatoma growth and proliferation: posttranscrip tional regulation by microRNA-21. (19672202)	Friedland D.R.... Cioffi J.A.	2009	PTEN, PDCD4, MIR21
4	The expression of receptor activator nuclear factor-kappaB ligand and osteoprotegerin in cholesteatoma (18589796)	Ma Y.... Ye S.	2008	TNFRSF11B, TNFSF11
5	Topical application of 5-fluorouracil on attic cholesteatoma results in downregulation of keratinocyte growth factor and reduction of proliferative activity. (18246360)	Yamamoto-Fukuda T.... Takahashi H.	2008	FGF7
6	Gelatinolytic activity of matrix metalloproteinases 2 and 9 in middle ear cholesteatoma. (19128667)	Suchozebrska-Jesionek D.... Stryjecka-Zimmer M.	2008	MMP2, MMP9
7	Laser-assisted cholesteatoma surgery: technical aspects, in vitro implementation and challenge of selective cell destruction. (18253741)	Caffier P.P.... Sedlmaier B.	2008	KRT14, KRT10
8	Expression and significance of nuclear factor-kappa B ligand and correlation factor in the tissue of otitis media with cholesteatoma (17580719)	Xia M.... Xu A.	2007	TNFRSF11B, TNFSF11, TNFRSF11A
9	The localization of matrix metalloproteinases-8 and -13 in cholesteatoma, deep-meatal and post-auricular skin: a comparative analysis. (17364344)	Mehta D.... Banerjee A.R.	2007	MMP8
10	The role of S100A1 in external auditory canal cholesteatoma. (16969478)	Naim R.... Hormann K.	2006	S100A1
11	Terminal differentiation and mitogen-activated protein kinase signaling in human cholesteatoma epithelium. (16639284)	Huisman M.A.... Grote J.J.	2006	IVL
12	Expression of the gap junction proteins connexin 26 and connexin 43 in human middle ear cholesteatoma. (16428189)	Choung Y.H.... Choung P.H.	2006	GJA1
13	Expression of secretory leukocyte protease inhibitor in middle ear cholesteatoma. (16868773)	Lee J.K.... Jung H.H.	2006	SLPI
14	Overexpression of placenta growth factor in human middle ear cholesteatoma. (16864484)	Cho J.G.... Chae S.W.	2006	PGF
15	The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium (16001900)	Ren X.... Xu M.	2005	DEFB4A
16	Expression of hypoxia-inducible factor-1alpha in middle ear cholesteatoma (15830692)	Liu Y.... Zhang P.	2005	HIF1A
17	Express of transforming growth factor alpha and beta1 in cholesteatoma tissue (16874966)	Li W.R.... Chen Z.N.	2005	TGFA
18	Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma (15620146)	Wang H.... Su J.	2004	MMP2, MMP9
19	Co-expression of different angiogenic factors in exte rnal auditory canal cholesteatoma. (15267172)	Naim R.... Hormann K.	2004	MET
20	The expression of matrix metalloproteinase-9 and tumor necrosis factor-alpha in cholesteatoma (15499988)	Li N.... Dong M.	2004	MMP9, TNF
21	Epidermal growth factor expression in middle ear cholesteatoma. (15481560)	Chi H.P.... Tsai S.M.	2004	EGF
22	Expression of beta-defensins in human middle ear cholesteatoma. (12701748)	Park K.... Choi H.S.	2003	DEFB1, DEFB4A
23	Osteoclast stimulating and differentiating factors in human cholesteatoma. (12616193)	Hamzei M.... Sudhoff H.	2003	TNFRSF11B, TNFSF11
24	Possible role of transforming growth factor alpha on the cholesteatoma growth regulation (12725186)	Xu Y.... Jin K.	2003	TGFA
25	Expression of vascular endothelial growth factor in external auditory canal cholesteatoma. (12684689)	Naim R.... Hormann K.	2003	VEGFA
26	The expression of matrix metalloproteinase-1 and interleukin-1-alpha messenger ribonucleic acid in human middle ear cholesteatoma (12768791)	Liu J.... Jiang Z.	2002	MMP1, IL1A
27	The levels of expression of galectin-3, but not of galectin-1 and galectin-8, correlate with apoptosis in human cholesteatomas. (11404618)	Sheikholeslam-Zadeh R.... Choufani G.	2001	LGALS3, LGALS1, LGALS8
28	Expression patterns of cytokeratins in retraction pocket cholesteatomas. (11404616)	Kim H.J.... Chole R.A.	2001	KRT4
29	Induction of matrix metalloproteinases in keratinocyt es by cholesteatoma debris and granulation tissue extracts. (11073191)	Schmidt M.... Hoppe F.	2000	MMP9
30	Carcinoembryonic antigen in chronic otitis media with cholesteatoma (10932614)	Sankovic-Babic S.... Sofronic-Milosavljevic L.j.	2000	CEACAM5
31	Terminal differentiation of epithelial cells in middle ear cholesteatoma: investigation of patterns of expression of protein kinase C-delta and protein kinase C-eta. (10569408)	Miyazaki H.... Moriyama H.	1999	PRKCH, KRT10, KRT1
32	Matrix metalloproteinase-1 in cholesteatoma, middle ear granulations and deep meatal skin: a comparative analysis. (9884804)	Banerjee A.R.... Lee R.J.	1998	MMP3, MMP1
33	Expression of transforming growth factor-alpha (TGF-alpha) in cholesteatoma. (9850316)	Shiwa M.... Moriyama H.	1998	TGFA
34	Expression of annexin II in human middle ear cholesteatoma. (9527111)	Kim T.T.... Huang C.C.	1998	ANXA2
35	Keratinocyte growth factor and receptor mRNA expression in cholesteatoma of the middle ear. (9349868)	Ishibashi T.... Fukaya T.	1997	FGFR2, FGF7
36	Interleukin-1 alpha, interleukin-1 beta and interleukin-8 gene expression in human aural cholesteatomas. (8725537)	Kim C.S.... Kim C.D.	1996	IL1A
37	Immunohistochemical detection of proliferating cell nuclear antigen in middle ear cholesteatoma. (8932424)	Bujia J.... Kastenbauer E.	1996	PCNA
38	Expression of messenger RNA for keratinocyte growth factor in human cholesteatoma. (8630209)	Kojima H.... Moriyama H.	1996	FGF7
39	A quantitative study of the presence of interleukin-1 and interleukin-6 in cholesteatoma of the middle ear (8962724)	Aumente P.O.... LA^pez Villarejo P.	1996	IL1A
40	Involvement of interleukin-1 in middle ear cholesteatoma. (7503375)	Shiwa M.... Moriyama H.	1995	IL1A
41	Cytokeratin expression patterns by one- and two-dimensional electrophoresis in pars flaccida cholesteatoma and pars tensa cholesteatoma. (8749203)	Kakoi H.... Kitajima Y.	1995	CKS1B
42	Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation , and programmed cell death. (7475882)	Shinoda H.... Huang C.C.	1995	JUN
43	Role of anaerobic bacteria in chronic otitis media an d cholesteatoma. (7782173)	Brook I.	1995	LACTB
44	Expression of human intercellular adhesion molecules in middle ear cholesteatoma. (7526720)	Bujia J.... Kastenbauer E.	1994	ICAM1, ICAM2
45	The roles of interleukin-1 alpha, tumor necrosis factor-alpha and parathyroid hormone-related protein in bone resorption of cholesteatoma otitis (7931803)	Kinoshita K.	1994	IL1A, PTHLH
46	Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. (7510866)	Sasaki H.... Huang C.C.	1994	KRT13
47	Immunohistochemical studies of vascularization of cholesteatoma (7684226)	Stammberger M.... Bujia J.	1993	TGFA
48	Localization of proliferating cell nuclear antigen in aural cholesteatoma. (7911858)	Uchida N.... Hirano M.	1993	PCNA
49	Hyperproliferation-associated keratin expression in human middle ear cholesteatoma. (7685977)	Bujia J.... Kastenbauer E.	1993	KRT16, KRT13
50	Keratinization of middle ear cholesteatomas. II. A histochemical study of epidermal transglutaminase substrates. (1697471)	Broekaert D.... Marquet J.	1990	IVL

Genes related to cholesteatoma according to GeneCards:

(show top 50)    (show all 101)

id	Symbol	Description	Score	GeneCards Section Context
1	KRT13	keratin 13	11.0	Publications
2	DEFB4A	defensin, beta 4A	11.0	Publications
3	IVL	involucrin	11.0	Publications
4	IL1A	interleukin 1, alpha	11.0	Publications
5	S100A8	S100 calcium binding protein A8	11.0	Publications
6	TGFA	transforming growth factor, alpha	11.0	Publications
7	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
8	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
9	KRT16	keratin 16	11.0	Publications
10	LGALS8	lectin, galactoside-binding, soluble, 8	11.0	Publications
11	KRT10	keratin 10	11.0	Publications
12	DEFB1	defensin, beta 1	11.0	Publications
13	FGF7	fibroblast growth factor 7	11.0	Publications
14	FLG	filaggrin	11.0	Publications
15	LGALS1	lectin, galactoside-binding, soluble, 1	11.0	Publications
16	CHKB	choline kinase beta	11.0	Publications
17	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
18	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
19	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
20	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
21	PCNA	proliferating cell nuclear antigen	11.0	Publications
22	ICAM1	intercellular adhesion molecule 1	11.0	Publications
23	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
24	JUN	jun proto-oncogene	11.0	Publications
25	EGF	epidermal growth factor	11.0	Publications
26	TMSB10	thymosin beta 10	11.0	Publications
27	DEFB103B	defensin, beta 103B	11.0	Publications
28	S100A7	S100 calcium binding protein A7	11.0	Publications
29	CASP14	caspase 14, apoptosis-related cysteine peptidase	11.0	Publications
30	ICAM2	intercellular adhesion molecule 2	11.0	Publications
31	CTSH	cathepsin H	11.0	Publications
32	S100A6	S100 calcium binding protein A6	11.0	Publications
33	KRT1	keratin 1	11.0	Publications
34	CCL20	chemokine (C-C motif) ligand 20	11.0	Publications
35	KRT14	keratin 14	11.0	Publications
36	S100A1	S100 calcium binding protein A1	11.0	Publications
37	PGF	placental growth factor	11.0	Publications
38	ANXA2	annexin A2	11.0	Publications
39	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
40	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
41	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
42	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
43	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
44	PRKCH	protein kinase C, eta	11.0	Publications
45	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
46	RARA	retinoic acid receptor, alpha	11.0	Publications
47	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
48	RARB	retinoic acid receptor, beta	11.0	Publications
49	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
50	NOS2	nitric oxide synthase 2, inducible	11.0	Publications

Pathways related to cholesteatoma according to GeneDecks:

(show top 50)    (show all 237)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.4	PCNA
2	Breast Cancer Regulation by Stathmin136	10.0	EGF, FGF2, PRKCH, TGFA, FGF7, FGFR2
3	Glioma Invasiveness36	9.9	PTN, TGFA, PGF, FGF2, HGF, FGF7
4	Immune response MIF-mediated glucocorticoid regulation10	9.8	JUN, MMP1, MIF, IL6, MAPK3, MAPK1
5	Immune response_MIF-mediated glucocorticoid regulation41	9.8	JUN, MIF, IL6, MAPK3, MAPK1, ICAM1
6	CREB Pathway36	9.7	PRKCA, PGF, PRKCH, FGFR2, FGF7, PTN
7	NF-KappaB (p50-p65) Pathway36	9.5	PGF, TGFB1, HGF, TGFA, EGFR, FGF2
8	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.5	JUN, PRKCH, SPP1, IL1B, TNFSF11, TNFRSF11B
9	Rheumatoid arthritis20	9.5	JUN, ITGAL, MMP1, MMP3, IL1A, IL1B
10	Akt Signaling36	9.4	MET, ITGAL, FGF7, IL6, TNF, TNFRSF11A
11	PPAR Pathway36	9.4	PGF, EGFR, ITGAL, FGF2, FGF7, FGFR2
12	Ras Pathway36	9.4	EGFR, FGF2, TGFA, MAPK1, JUN, FGFR2
13	MIF Regulation of Innate Immune Cells36	9.3	NFKB1, JUN, MIF, IL1A, IL1B, MAPK1
14	PAK Pathway36	9.2	PGF, IL6, CSF2, IL1B, TNF, TNFSF11
15	14-3-3 Induced Intracellular Signaling36	9.2	JUN, FGF2, FGF7, FGFR2, MAPK3, MAPK1
16	Endothelin-1 Signaling Pathway36	9.1	FGFR2, MAPK3, IL1A, IL1B, IL6, PRKCA
17	ILK Signaling36	9.0	PTN, CTNNB1, EGF, EGFR, HIF1A, TGFA
18	NF-KappaB Family Pathway36	8.9	FGF2, FGF7, FGFR2, MET, IL1A, IL1B
19	TGF-Beta Pathway36	8.9	JUN, HGF, PGF, TGFB1, FGF2, FGF7
20	Apoptotic Pathways in Synovial Fibroblasts36	8.8	FGF2, FGF7, FGFR2, MET, IL6, TP53
21	Signal transduction PTEN pathway10	8.8	JUN, MAPK1, PCNA, CDKN1A, MAPK3, PTEN
22	Rac1 Pathway36	8.8	TGFB1, PGF, HGF, TGFA, EGFR, JUN
23	MAPK Family Pathway36	8.8	TGFA, TGFB1, PGF, HGF, EGFR, EGF
24	JAK-STAT Pathway36	8.7	HGF, FGFR2, FGF7, FGF2, JUN, MET
25	Tec Kinases Signaling36	8.5	IL1B, IL6, CCL20, TNF, TNFRSF11A, PTN
26	Rho Family GTPases36	8.5	CSF2, PGF, HGF, TGFB1, JUN, ITGAL
27	ERK Signaling36	8.5	FGFR2, IL1A, IL6, MAPK3, MAPK1, CCL20
28	p53 Mediated Apoptosis36	8.4	EGFR, HGF, PGF, TGFB1, FGF2, FGF7
29	mTOR Pathway36	8.4	FGF2, TGFA, HIF1A, EGF, PTN, MAPK1
30	Nanog in Mammalian ESC Pluripotency36	8.4	FGF2, TGFA, TGFB1, PGF, HGF, MET
31	Activation of PKC through GPCR36	8.3	MAPK3, MET, PGF, PRKCA, TGFB1, HGF
32	Renin-Angiotensin Pathway36	8.3	MET, FGF2, FGF7, FGFR2, MAPK1, MAPK3
33	p70S6K Signaling36	8.3	PRKCH, TGFB1, TGFA, EGFR, EGF, PTN
34	Mitochondrial Apoptosis36	8.3	CDKN2A, FGF2, FGF7, FGFR2, MET, IL6
35	GPCR Pathway36	8.2	FGF2, HGF, PGF, PRKCA, PRKCH, TGFB1
36	NFAT in Immune Response36	8.2	NFKB1, PTN, MAPK1, MAPK3, IL6, PGF
37	Cellular Apoptosis Pathway36	8.1	FGFR2, MET, IL6, TP53, TNF, PTN
38	PTEN Pathway36	8.1	ITGAL, FGF2, FGF7, FGFR2, MET, MAPK1
39	Telomerase Components in Cell Signaling36	7.9	TGFB1, PRKCA, PGF, HGF, TGFA, EGFR
40	Antioxidant Action of Vitamin-C36	7.9	EGFR, TGFA, TGFB1, PRKCH, PRKCA, CSF2
41	Bladder cancer20	7.9	PGF, VEGFA, CDKN1A, CDKN2A, MMP1, MMP2
42	Phospholipase-C Pathway36	7.8	PGF, EGFR, TGFA, TGFB1, PRKCH, PRKCA
43	p38 Signaling36	7.8	FGF2, FGF7, FGFR2, MET, IL1A, IL1B
44	Melanoma20	7.5	FGF7, MET, MAPK3, MAPK1, TP53, EGF
45	Colorectal Cancer Metastasis36	7.5	MAPK1, TGFB1, EGFR, EGF, NFKB1, CTNNB1
46	Prostate cancer20	7.4	TGFA, CTNNB1, EGFR, EGF, NFKB1, PTEN
47	MAPK Signaling36	6.9	TGFB1, PTN, TNF, TGFA, EGFR, EGF
48	Pancreatic Adenocarcinoma36	6.7	IL6, MAPK3, MAPK1, TP53, PTN, NFKB1
49	Molecular Mechanisms of Cancer36	5.4	CDK2, CDKN2A, ITGAL, FGF2, FGFR2, MET
50	Pathways in cancer20	5.2	HGF, PRKCA, TGFB1, MMP2, MMP1, CDK2

Compounds related to cholesteatoma according to GeneDecks:

(show top 50)    (show all 410)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.5	MUC5AC, FGFR2, KRT1, KRT10, KRT14, SLC3A2
2	h2o232	10.2	LGALS3, ITGAL, MMP8, MIF, FGFR2, ICAM1
3	ns 39832 42	10.9	PCNA, MMP1, FGF2, IL1A, IL1B, MAPK1
4	egcg32	9.8	CDK2, IVL, IL1A, MAPK3, CASP14, PRKCA
5	rantes32	9.7	JUN, ITGAL, MMP1, MMP3, MMP9, MIF
6	endotoxin32	9.7	CHKB, S100A8, ITGAL, MIF, CCL20, F8
7	hydrocortisone32 9 9	11.4	IVL, MMP1, MMP2, MIF, FGF2, FGF7
8	polysaccharide32	9.4	LGALS1, LGALS3, LGALS8, CHKB, IVL, FGF2
9	hyaluronic acid32 18	10.4	CEACAM5, ITGAL, MMP1, MMP3, FGF2, FGF7
10	methotrexate32 34 42 9 9	13.3	PCNA, BIRC5, CHKB, MUC5AC, S100A8, CDKN2A
11	pge232	9.3	MUC5AC, IVL, MMP1, MMP3, MMP8, FGF2
12	pd15303532	9.2	VEGFA, BIRC5, JUN, MMP1, MAPK1, PTHLH
13	tetracycline32 9 9	11.0	LACTB, S100A8, CDK2, CDKN2A, MMP1, MMP2
14	ly29400232	9.0	VEGFA, RARA, JUN, MMP2, MMP9, FGF2
15	rapamycin32 42	9.8	VEGFA, LGALS1, CDK2, FGF7, MET, TERT
16	latex32	8.8	LGALS3, CHKB, CEACAM5, ITGAL, FLG, FGF7
17	ribonucleic acid32	8.7	RARA, RARB, MUC5AC, CEACAM5, MMP1, MMP2
18	cyclosporin a32 42	9.7	PCNA, CHKB, JUN, CDK2, IVL, ITGAL
19	creatinine32	8.6	PCNA, LCN2, S100A8, CDK2, CDKN2A, MMP1
20	ciglitazone32	8.5	RARA, RARB, JUN, CDKN1A, MMP2, MMP9
21	suramin32 9 9	10.5	PCNA, VEGFA, CDK2, IVL, FGF2, FGF7
22	doxycycline32 9 9	10.4	LACTB, CDK2, CDKN2A, MMP1, MMP2, MMP3
23	bromodeoxyuridine32	8.4	PCNA, CDKN1A, CDK2, IVL, MKI67, FLG
24	proline32	8.0	LGALS3, MUC5AC, IVL, ITGAL, MMP2, MMP8
25	heparin32 9 18 9	11.0	LGALS1, LGALS3, CHKB, CDK2, ITGAL, MMP3
26	indomethacin32 9 9	10.0	PCNA, BIRC5, LGALS1, CDK2, MMP1, MMP3
27	troglitazone32 42 9 9	10.9	RARA, BIRC5, JUN, CDKN1A, CDK2, MMP1
28	ag 147832	7.8	MUC5AC, JUN, CDK2, MMP2, MMP9, MET
29	glutamate32	7.6	PCNA, LGALS3, S100A8, CDK2, ITGAL, MMP2
30	tgf beta132	7.6	RARA, CDKN1A, CDK2, MMP1, MMP2, MMP3
31	pdtc32	7.5	BIRC5, JUN, CDKN1A, MMP1, MMP2, MMP9
32	cysteine32	7.4	PCNA, RARA, RARB, LGALS1, LGALS3, CHKB
33	gf 109203x32 42	8.4	VEGFA, JUN, CDKN1A, IVL, MMP1, FLG
34	testosterone32 9 18 9	9.9	PCNA, RARA, RARB, BIRC5, CHKB, MUC5AC
35	progesterone32 42 9 18 9	10.8	PCNA, RARA, RARB, BIRC5, S100A1, S100A6
36	gefitinib32 34 9 9	9.8	VEGFA, BIRC5, CEACAM5, CDKN1A, CDK2, MMP2
37	doxorubicin32 34 9 9	9.7	CEACAM5, CDK2, ITGAL, MMP1, MKI67, MIF
38	resveratrol32 9 18 9	9.5	PCNA, VEGFA, BIRC5, JUN, CDKN1A, CDK2
39	etoposide32 42 9 9	9.4	PCNA, RARA, BIRC5, LGALS1, LGALS3, JUN
40	curcumin32	6.2	VEGFA, BIRC5, JUN, CDKN1A, CDK2, IVL
41	tamoxifen32 34 9 9	9.0	PCNA, VEGFA, RARA, BIRC5, CHKB, JUN
42	alanine32	5.9	PCNA, RARA, BIRC5, LGALS3, CHKB, S100A8
43	dexamethasone32 42 34 9 9	9.8	PCNA, VEGFA, RARA, RARB, BIRC5, LGALS1
44	phosphatidylinositol32	5.4	RARA, BIRC5, LGALS3, LGALS8, MUC5AC, CEACAM5
45	paclitaxel32 34 9 9	7.7	PCNA, VEGFA, RARA, BIRC5, CDKN1A, CDK2
46	vegf32	4.1	PCNA, LGALS3, CHKB, CEACAM5, CDKN1A, CDK2
47	cycloheximide32	3.9	VEGFA, RARA, RARB, BIRC5, JUN, CDKN1A
48	cisplatin32 34 9 9	6.6	PCNA, VEGFA, RARB, BIRC5, LGALS3, CEACAM5
49	tyrosine32	3.0	VEGFA, RARA, RARB, BIRC5, LGALS1, LGALS3
50	serine32	2.7	RARA, BIRC5, LGALS1, LGALS3, MUC5AC, LCN2

Cellular components related to cholesteatoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	keratin filament	GO:045095	10.3	KRT14, KRT10, KRT1, KRT13, KRT4, CASP14
2	intermediate filament	GO:005882	10.2	KRT14, KRT10, KRT1, KRT16, KRT4, FLG
3	proteinaceous extracellular matrix	GO:005578	9.8	TGFB1, TNFRSF11B, MMP9, MMP8, MMP3, MMP2
4	cell surface	GO:009986	9.6	TNF, TGFA, TGFB1, SLC3A2, IL1A, FGFR2
5	platelet alpha granule lumen	GO:031093	9.2	HGF, TGFB1, EGF, F8, VEGFA
6	extracellular region	GO:005576	7.7	CTSD, SPP1, PTHLH, TNFSF11, TNFRSF11B, F8
7	extracellular space	GO:005615	7.4	HGF, TNF, TNFRSF11B, TNFSF11, PTN, PTHLH
8	nucleoplasm	GO:005654	6.5	MAPK1, TP53, TERT, NFKB1, HIF1A, PRKCA
9	cytosol	GO:005829	5.8	GJA1, TP53, PTEN, CTSH, CTNNB1, NOS2
10	cytoplasm	GO:005737	4.8	SPRR1B, PTHLH, PTEN, TERT, TMSB10, TNFSF11

Biological processes related to cholesteatoma according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to radiation	GO:009314	10.7	TGFB1, KRT13, TNFSF11, MMP9, JUN
2	wound healing	GO:042060	10.7	TGFA, IL1B, IL1A, FGF7, FGF2, S100A8
3	collagen catabolic process	GO:030574	10.7	MMP9, MMP8, MMP3, MMP2, MMP1
4	extracellular matrix disassembly	GO:022617	10.6	MMP9, MMP8, MMP3, MMP2, MMP1
5	mammary gland alveolus development	GO:060749	10.6	TNFRSF11A, TNFSF11, EGF, TGFA
6	keratinocyte differentiation	GO:030216	10.6	TGM3, KRT10, SPRR1B, FLG, IVL, S100A7
7	extracellular matrix organization	GO:030198	10.5	TNFRSF11B, TNF, MMP9, MMP8, MMP3, MMP2
8	positive regulation of mitosis	GO:045840	10.4	TGFA, EGF, TNF, IL1B, IL1A, MET
9	epidermis development	GO:008544	10.4	KRT16, KRT1, KRT10, KRT14, KRT13, SPRR1B
10	ossification	GO:001503	10.3	OSTF1, EGFR, TNFSF11, TNFRSF11A, MMP9, MMP8
11	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.3	PRKCH, TGFB1, NFKB1, TNFSF11, TNFRSF11A, TNF
12	positive regulation vascular endothelial growth factor production	GO:010575	10.2	IL1A, IL1B, HIF1A, TGFB1
13	cellular response to organic cyclic compound	GO:071407	10.1	TGFB1, CTNNB1, TNF, IL1B, LGALS1
14	positive regulation of MAP kinase activity	GO:043406	10.1	TGFB1, EGFR, EGF, TNFSF11, TNF, VEGFA
15	osteoclast differentiation	GO:030316	10.1	CTNNB1, TNFSF11, TNFRSF11A, TNF
16	inflammatory response	GO:006954	10.0	TNF, SPP1, NFKB1, TGFB1, CCL20, IL6
17	positive regulation of cell division	GO:051781	10.0	PGF, TGFB1, TGFA, PTN, IL1B, IL1A
18	response to hypoxia	GO:001666	10.0	PGF, TGFB1, HIF1A, NOS2, TNF, IL1B
19	positive regulation of fibroblast proliferation	GO:048146	9.9	EGFR, MIF, CDKN1A, JUN, S100A6
20	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	PRKCA, HIF1A, TNF, IL6, JUN
21	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.9	PTEN, TNFSF11, TNFRSF11A, TNF, IL6, IL1B
22	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	PRKCA, TNF, MAPK3, IL1B, IL1A, FGFR2
23	MAPK cascade	GO:000165	9.9	TGFB1, TGFA, EGFR, TNF, MAPK1, MAPK3
24	positive regulation of peptidyl-threonine phosphorylation	GO:010800	9.8	TGFB1, EGF, MAPK1, MET
25	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.8	TGFB1, TNF, IL6, MET, MIF, VEGFA
26	positive regulation of angiogenesis	GO:045766	9.7	PRKCA, HIF1A, CTSH, IL1B, IL1A, FGF2
27	positive regulation of endothelial cell proliferation	GO:001938	9.7	PGF, PRKCA, HIF1A, FGF2, JUN, VEGFA
28	positive regulation of blood vessel endothelial cell migration	GO:043536	9.6	PRKCA, TGFB1, FGF2, VEGFA
29	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO:060665	9.5	HGF, MET, FGF7
30	innate immune response	GO:045087	9.4	DEFB1, NFKB1, MAPK1, MAPK3, MIF, JUN
31	activation of MAPK activity	GO:000187	9.4	HGF, TGFA, TNF, MAPK1, MAPK3, IL1B
32	response to estradiol stimulus	GO:032355	9.3	PRKCA, TGFB1, CTNNB1, IL1B, MMP9, RARA
33	response to drug	GO:042493	9.3	TNFRSF11B, CTNNB1, TGFA, TGFB1, PGF, TNF
34	angiogenesis	GO:001525	9.3	EGF, HIF1A, TGFA, PRKCA, PGF, PTEN
35	epidermal growth factor receptor signaling pathway	GO:007173	9.1	PRKCA, TGFB1, TGFA, EGFR, EGF, PTEN
36	cell proliferation	GO:008283	9.1	TGFA, EGFR, KRT16, PTEN, TP53, IL1A
37	fibroblast growth factor receptor signaling pathway	GO:008543	9.1	PRKCA, PTEN, MAPK1, MAPK3, FGFR2, FGF7
38	positive regulation of protein phosphorylation	GO:001934	9.0	PRKCA, TGFB1, TNF, MAPK3, IL1B, VEGFA
39	replicative senescence	GO:090399	9.0	CDKN1A, CDKN2A, TP53, TERT
40	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	HGF, TP53, IL6, FGF7, MIF, VEGFA
41	positive regulation of transcription, DNA-dependent	GO:045893	8.8	TNF, CTNNB1, NFKB1, EGF, HIF1A, TGFB1
42	signal transduction	GO:007165	8.5	TNFRSF11A, TNFRSF11B, EGF, EGFR, HIF1A, OSTF1
43	positive regulation of cell proliferation	GO:008284	8.5	VEGFA, PGF, CSF2, TGFB1, EGFR, EGF
44	Ras protein signal transduction	GO:007265	8.4	TP53, MAPK1, MAPK3, FGF2, CDKN2A, CDK2
45	platelet activation	GO:030168	8.2	HGF, PRKCA, PRKCH, TGFB1, EGF, F8
46	negative regulation of apoptotic process	GO:043066	8.1	CSF2, EGFR, CTSH, PTEN, TNF, TP53
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	TP53, TNF, TNFSF11, CTNNB1, NFKB1, HEXB
48	negative regulation of cell proliferation	GO:008285	7.5	TP53, TNF, PTEN, PTHLH, CTNNB1, TGFB1
49	apoptotic process	GO:006915	7.2	GJA1, TP53, TNF, TNFRSF11B, PTEN, CTNNB1
50	blood coagulation	GO:007596	6.8	EGF, TGFB1, PRKCH, PRKCA, SLC3A2, HGF

Molecular functions related to cholesteatoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemoattractant activity	GO:042056	9.9	VEGFA, MIF, FGF2, FGF7
2	cytokine activity	GO:005125	9.4	CSF2, SPP1, TNFSF11, TNFRSF11B, TNF, IL6
3	calcium ion binding	GO:005509	9.4	MMP3, MMP8, FLG, ANXA2, EGF, TGM3
4	growth factor activity	GO:008083	9.2	TGFA, TGFB1, CSF2, PGF, HGF, EGF
5	protein homodimerization activity	GO:042803	8.7	TERT, NOS2, NFKB1, HEXB, TGFB1, PGF
6	enzyme binding	GO:019899	7.9	TGFB1, PRKCH, PRKCA, SLPI, HIF1A, EGFR
7	protein heterodimerization activity	GO:046982	7.7	HEXB, HIF1A, TGFB1, PGF, HGF, EGFR
8	protein binding	GO:005515	3.0	HGF, NOS2, CTNNB1, CTSH, PTEN, TERT