MCID: CHL069
MIFTS: 51

Cholesteatoma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cholesteatoma

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Aliases & Descriptions for Cholesteatoma:

Name: Cholesteatoma 11 47 49 38 13 67
Secondary Acquired Cholesteatoma 47
 
Primary Acquired Cholesteatoma 47
Congenital Cholesteatoma 47

Classifications:



External Ids:

Disease Ontology11 DOID:869
ICD1029 H71.9, H71.90
ICD9CM31 385.30
MeSH38 D002781
NCIt44 C2944

Summaries for Cholesteatoma

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Disease Ontology:11 A keratosis characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.

MalaCards based summary: Cholesteatoma, also known as secondary acquired cholesteatoma, is related to otosclerosis and neuroma, and has symptoms including paraesthesia ear, itching of ear and ear congestion. An important gene associated with Cholesteatoma is LGALS8 (Galectin 8), and among its related pathways are Osteoblast Signaling and Osteoclast Signaling. Affiliated tissues include middle ear, bone and brain, and related mouse phenotypes are integument and craniofacial.

Wikipedia:70 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma

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Diseases related to Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1otosclerosis30.1DEFB4A, KRT16
2neuroma29.9MMP9, TNFRSF11B, TNFSF11
3cholesteatoma of middle ear12.2
4cholesteatoma of external ear12.2
5maxillary sinus cholesteatoma12.1
6cholesteatoma of attic11.9
7purulent labyrinthitis10.8
8focal labyrinthitis10.8
9diabetic cataract10.7IL1A, MMP9
10follicular mucinosis10.6MMP9, TNFSF11
11angioimmunoblastic lymphadenopathy with dysproteinemia10.6DEFB4A, MMP9
12ichthyosis histrix, curth-macklin type10.6KRT10, KRT16
13osteopetrosis, autosomal recessive 710.5TNFRSF11B, TNFSF11
14epidermolytic acanthoma10.5KRT10, KRT14
15hemorrhagic shock and encephalopathy syndrome10.5TNFRSF11B, TNFSF11
16tibial hemimelia10.5TNFRSF11B, TNFSF11
17myopia10.5TNFRSF11B, TNFSF11
18metatypical basal cell carcinoma10.5KRT10, KRT14
19hemoglobin d disease10.5KRT10, KRT14
20solar retinopathy10.5TNFRSF11B, TNFSF11
21craniodiaphyseal dysplasia, autosomal dominant10.5KRT10, KRT16
22gastric squamous cell carcinoma10.5KRT10, KRT14
23ameloblastic carcinoma10.5MMP8, MMP9
24small intestine lymphoma10.5IL1A, TNF
25classic endocrine tumor of appendix10.4FLG, MMP9
26otitis media10.4
27complex lethal osteochondrodysplasia10.4KRT10, KRT16
28liver disease10.4IL1A, KRT13, KRT14
29brachydactyly type a310.4FLG, KRT10
30epstein-barr virus hepatitis10.4IL1A, TNF
31zellweger-like syndrome without peroxisomal anomalies10.4MMP2, MMP9
32anaerobic meningitis10.4IL1A, TNFRSF11B, TNFSF11
33gonococcal synovitis10.4MMP9, TNF
34nerve root neoplasm10.4KRT10, KRT13, KRT14
35pathological gambling10.4MMP2, MMP9
36myosin storage myopathy10.4MMP2, MMP9
37renal pelvis carcinoma10.4MMP2, MMP9
38cannabis dependence10.4MMP9, TNFRSF11B, TNFSF11
39bullous keratopathy10.4KRT10, KRT14, KRT16
40familial retinoblastoma10.3KRT10, KRT14, KRT16
41astrocytoma10.3IL1A, TNF
42meningothelial meningioma10.3MMP2, MMP9
43gingivitis10.3IL1A, MMP9, TNF
44malignant giant cell tumor10.3MMP9, TNF, TNFSF11
45pleomorphic lipoma10.3IL1A, TNF, TNFSF11
46blepharochalasis10.3MMP9, TNF, TNFSF11
47emphysematous cholecystitis10.3MMP2, MMP9
48deletion 5q3510.3MMP2, MMP9
49epiphyseal dysplasia, multiple, with severe proximal femoral dysplasia10.3KRT14, KRT16
50sialadenitis10.3MMP2, MMP9

Graphical network of the top 20 diseases related to Cholesteatoma:



Diseases related to cholesteatoma

Symptoms for Cholesteatoma

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UMLS symptoms related to Cholesteatoma:


paraesthesia ear, itching of ear, ear congestion, auricular swelling, erythematous ear canal, earache

Drugs & Therapeutics for Cholesteatoma

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Drugs for Cholesteatoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ClonidineapprovedPhase 22264205-90-72803
Synonyms:
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI)
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
2,6-dichloro-N-(2-imidazolidinylidene)aniline
2,6-dichloro-N-2-imidazolidinylidenebenzenamide
2,6-dichloro-N-imidazolidin-2-ylideneaniline
2-((2,6-Dichlorophenyl)imino)imidazolidine
2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
2-(2,6-Dichloroanilino)-2-imidazoline
2-(2,6-Dichlorophenylamino)-2-imidazoline
2-(2,6-Dichlorophenylimino)imidazolidine
2-Imidazoline, 2-(2,6-dichloroanilino)- (7CI,8CI)
2-[(2,6-Dichlorophenyl)imino]imidazoline
2-[(2,6-dichlorophenyl)imino]-2-imidazoline
4205-90-7
4205-91-8 (mono-hydrochloride)
57066-25-8
734571A
AB00514634
AC1L1EI5
AC1Q3K6V
AKOS001595470
Adesipress
BIDD:GT0547
BPBio1_000040
BRD-K98530306-001-02-1
BRD-K98530306-003-05-0
BSPBio_000036
BSPBio_001588
BSPBio_002055
Bio1_000470
Bio1_000959
Bio1_001448
Bio2_000308
Bio2_000788
C9H9Cl2N3
CAS-4205-91-8
CATAPRES-TTS-1
CATAPRES-TTS-2
CATAPRES-TTS-3
CCRIS 7787
CHEBI:3757
CHEBI:46632
CHEMBL134
CID2803
Catapres
Catapres- TTS
Catapres-TTS
Catapresan
Catapressan
Catarpres
Catarpres-TTS
Catarpres-TTS (TN)
Catarpresan
Chlofazoline
Chlornidinum
Clofenil
Clonidin
Clonidina
Clonidina [INN-Spanish]
Clonidine (JAN/USAN/INN)
Clonidine HCl
Clonidine [USAN:BAN:INN]
Clonidinhydrochlorid
Clonidinum
Clonidinum [INN-Latin]
Clonistada
Clopheline
D00281
DB00575
DB07566
DivK1c_000774
 
Dixarit
Duraclon
Duraclont
EINECS 224-119-4
Gemiton
HMS1361P10
HMS1791P10
HMS1989P10
HMS2089G11
HSDB 3040
Hemiton
IDI1_000774
IDI1_034058
Ipotensium
Isoglaucon
KBio1_000774
KBio2_000308
KBio2_001821
KBio2_002876
KBio2_004389
KBio2_005444
KBio2_006957
KBio3_000615
KBio3_000616
KBio3_001275
KBioGR_000308
KBioGR_001572
KBioSS_000308
KBioSS_001821
Klofelin
Klofenil
L000193
LS-79606
Lopac-C-7897
Lopac0_000268
M 5041T
M-5041T
MolPort-001-779-668
MolPort-005-932-374
N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
NCGC00015268-01
NCGC00015268-02
NCGC00015268-08
NCGC00024734-01
NCGC00024734-02
NCGC00024734-03
NCGC00024734-04
NCGC00024734-05
NCGC00179680-01
NINDS_000774
Prestwick0_000248
Prestwick1_000248
Prestwick2_000248
Prestwick3_000248
SKF 34427
SPBio_001233
SPBio_002255
ST 155BS
ST-155-BS
ST-155BS
Spectrum2_001187
Spectrum3_000358
Spectrum4_000956
Spectrum5_000759
Spectrum_001341
T171
Tenso-Timelets
Tocris-0690
UNII-MN3L5RMN02
ZINC00896484
clonidine
nchembio.79-comp11
nchembio705-10
2
Bupivacaineapproved, investigationalPhase 211312180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(┬▒)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
3Central Nervous System DepressantsPhase 212806
4Neurotransmitter AgentsPhase 217734
5SympatholyticsPhase 2555
6Peripheral Nervous System AgentsPhase 222776
7Autonomic AgentsPhase 29774
8Antihypertensive AgentsPhase 24095
9Adrenergic alpha-2 Receptor AgonistsPhase 2911
10Adrenergic AgonistsPhase 22877
11Adrenergic alpha-AgonistsPhase 21625
12AnalgesicsPhase 211287
13Anesthetics, LocalPhase 23272
14AnestheticsPhase 29001
15Adrenergic AgentsPhase 25140

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis MediaUnknown statusNCT00270660Phase 3
2Great Auricular Nerve Block for Tympanomastoid Surgery: Will the Addition of Clonidine Enhance the Duration of Analgesia?CompletedNCT01638052Phase 2
3Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
4Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in ChildrenCompletedNCT00682409
5Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
6Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
7Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
8Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma


Cochrane evidence based reviews: cholesteatoma

Genetic Tests for Cholesteatoma

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Anatomical Context for Cholesteatoma

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MalaCards organs/tissues related to Cholesteatoma:

35
Bone, Brain, Skin, Testes, Endothelial, Temporal lobe, Neutrophil

FMA organs/tissues related to Cholesteatoma:

17
Middle ear

Animal Models for Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5FGFR2, IL1A, KRT14, KRT16, MMP9, TNF
2MP:00053828.1FGFR2, KRT14, KRT16, MMP2, TNF, TNFRSF11B
3MP:00020067.2FGFR2, IL1A, KRT14, MMP2, MMP8, MMP9
4MP:00053877.2FGFR2, IL1A, KRT14, MMP2, MMP8, MMP9

Publications for Cholesteatoma

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Articles related to Cholesteatoma:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
Tubal function tests with optional myringotomy detect Eustachian tube closing failure in acquired pars flaccida retraction cholesteatoma. (27427536)
2016
2
Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. (27117903)
2016
3
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
4
Health-related quality of life measurement after cholesteatoma surgery: comparison of three different surgical techniques. (25359196)
2014
5
Recurrent aseptic meningitis as a rare but important presentation of congenital petrous apex cholesteatoma: the value of appropriate imaging. (24614768)
2014
6
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
7
Extradural granulation complicated by chronic suppurative otitis media with cholesteatoma. (24982237)
2014
8
Congenital cholesteatoma in identical twins. (23217274)
2013
9
Differential gene expression in cholesteatoma by DNA chip analysis. (23670528)
2013
10
Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear. (23299781)
2013
11
How long is long enough to follow up children after cholesteatoma surgery? A 29-year study. (23108885)
2012
12
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
13
The pathogenesis of acquired cholesteatoma of the human middle ear: support for the migration hypothesis. (22143292)
2012
14
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
15
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
16
Acquired cholesteatoma: classification and outcomes. (21725267)
2011
17
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
18
Petrous bone cholesteatoma: classification, management and review of the literature. (20668373)
2011
19
Recurrence of cholesteatoma mimicking dural herniation. (24303377)
2011
20
Biofilms in chronic suppurative otitis media and cholesteatoma: scanning electron microscopy findings. (20036033)
2011
21
The utility of diffusion-weighted imaging for cholesteatoma evaluation. (20488909)
2011
22
Bilateral congenital cholesteatoma: report of an emblematic case. (21563559)
2011
23
Osteoplastic atticoantrotomy with autologous bone chips and a bony attic strut in cholesteatoma surgery. (19953260)
2010
24
Mastoid subperiosteal abscess as a first sign of unnoticed cholesteatoma in children. (19814752)
2010
25
Tympanic membrane cholesteatoma: a rare finding. (20718191)
2010
26
Management of complex cases of petrous bone cholesteatoma. (20860276)
2010
27
Diffusion-weighted MR imaging in postoperative follow-up: reliability for detection of recurrent cholesteatoma. (19231123)
2010
28
The ongoing dilemma of residual cholesteatoma detection: are current magnetic resonance imaging techniques good enough? (20202277)
2010
29
Canal wall-down mastoidectomy with mastoid obliteration for pediatric cholesteatoma. (19565369)
2010
30
External auditory canal cholesteatoma: a rare complication of tympanoplasty. (19924662)
2009
31
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
32
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (18419858)
2008
33
Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. (19144300)
2008
34
Endoscope-assisted surgery via the middle cranial fossa approach for a petrous cholesteatoma. (18226484)
2008
35
Giant Cholesteatoma: Recommendations for Follow-up. (19240835)
2008
36
Transforming growth factor beta and wound healing in human cholesteatoma. (17989584)
2008
37
The value of magnetic resonance imaging in the diagnosis of residual or recurrent acquired cholesteatoma after canal wall-up tympanoplasty. (18199952)
2008
38
Staged tympanostomy tube placement facilitates pediatric cholesteatoma management. (18023884)
2008
39
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
40
Applicability of autologous incus: the influence of age and localization of cholesteatoma. (17415579)
2007
41
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
42
Petrous bone cholesteatoma: clinical longitudinal study. (17082945)
2007
43
A new case of synchronous primary external ear canal cholesteatoma. (16730556)
2006
44
Some markers of proliferative activity in cholesteatoma epithelium in adults. (16865065)
2006
45
Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture. (15875782)
2005
46
Sustained extracellular signal-regulated kinase1/2 mitogen-activated protein kinase signalling is related to increased p21 expression in cholesteatoma epithelium. (15880942)
2005
47
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
48
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
49
Roles of cytokines and cell cycle regulating substances in proliferation of cholesteatoma epithelium. (10401849)
1999
50
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991

Variations for Cholesteatoma

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Expression for genes affiliated with Cholesteatoma

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Search GEO for disease gene expression data for Cholesteatoma.

Pathways for genes affiliated with Cholesteatoma

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GO Terms for genes affiliated with Cholesteatoma

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Cellular components related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.6FLG, KRT10, KRT14, KRT16
2proteinaceous extracellular matrixGO:00055788.7MMP2, MMP8, MMP9, TNFRSF11B
3extracellular spaceGO:00056155.9DEFB1, DEFB4A, IL1A, KRT10, LGALS8, MMP2
4extracellular regionGO:00055765.7DEFB1, DEFB4A, FGFR2, IL1A, MMP2, MMP8

Biological processes related to Cholesteatoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1hair cycleGO:004263310.5KRT14, KRT16
2establishment of skin barrierGO:006143610.3FLG, KRT16
3keratinocyte differentiationGO:003021610.1FLG, KRT10, KRT16
4epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.9FGFR2, TNF
5positive regulation of osteoclast differentiationGO:00456729.8TNF, TNFSF11
6regulation of osteoclast differentiationGO:00456709.7TNF, TNFSF11
7positive regulation of vascular smooth muscle cell proliferationGO:19047079.7MMP2, MMP9
8endodermal cell differentiationGO:00359879.5MMP2, MMP8, MMP9
9positive regulation of JNK cascadeGO:00463309.5IL1A, TNF, TNFSF11
10tumor necrosis factor-mediated signaling pathwayGO:00332099.4TNF, TNFRSF11B, TNFSF11
11collagen catabolic processGO:00305749.4MMP2, MMP8, MMP9
12extracellular matrix disassemblyGO:00226179.3MMP2, MMP8, MMP9
13animal organ morphogenesisGO:00098879.0FGFR2, TNF, TNFSF11
14defense response to Gram-positive bacteriumGO:00508308.8DEFB1, DEFB4A, TNF
15immune responseGO:00069558.3DEFB1, DEFB4A, IL1A, TNFRSF11B, TNFSF11

Molecular functions related to Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR6 chemokine receptor bindingGO:00317319.7DEFB1, DEFB4A
2metalloendopeptidase activityGO:00042229.3MMP2, MMP8, MMP9
3cytokine activityGO:00051258.6IL1A, TNF, TNFRSF11B, TNFSF11

Sources for Cholesteatoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet