MCID: CHL122
MIFTS: 38

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

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Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 11 13
Middle Ear Cholesteatoma 11 67
Cholesteatoma of Middle Ear and/or Mastoid 11
Cholesteatoma of Middle Ear and Mastoid 11
Cholesteatoma of the Middle Ear 11
Epidermosis of Middle Ear 11
 
Cholesteatoma, Middle Ear 38
Unspecified Cholesteatoma 11
Cholesteatoma Middle Ear 49
Epidermosis of Ear 11
Cholesteatoma 67

Classifications:



External Ids:

Disease Ontology11 DOID:10964
ICD1029 H71
MeSH38 D018424
NCIt44 C3654

Summaries for Cholesteatoma of Middle Ear

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MalaCards based summary: Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to diabetic cataract and pulmonary valve insufficiency, and has symptoms including paraesthesia ear, itching of ear and ear congestion. An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways are a6b1 and a6b4 Integrin signaling and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Affiliated tissues include testes and skin, and related mouse phenotypes are integument and muscle.

Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic cataract10.5IL1A, MMP9
2pulmonary valve insufficiency10.5DEFB4A, IL1A
3uterus carcinoma in situ10.5DEFB4A, IL1A
4chronic rheumatic pericarditis10.4IL1A, TNFSF11
5accessory nerve disease10.4DEFB4A, IL1A
6inflammatory liposarcoma10.4MMP9, TNFSF11
7anaerobic meningitis10.4IL1A, TNFSF11
8malignant giant cell tumor of the tendon sheath10.3MMP9, TNFSF11
9optic atrophy 710.3IL1A, MMP1
10pathological gambling10.3MMP1, MMP9
11classic endocrine tumor of appendix10.3MMP1, MMP9
12atrichia with papular lesions10.3ICAM1, IL1A
13antidepressant or antipsychotic toxicity or dose selection10.3MMP9, TNFSF11
14emphysematous cholecystitis10.3MMP1, MMP9
15mechanical ectropion10.3MMP1, MMP9
16juvenile astrocytoma10.3MMP1, MMP9
17limb reduction defect10.3MMP1, MMP9
18retinal degeneration10.3MMP1, MMP9
19adenosine monophosphate deaminase 1 deficiency10.3MMP1, MMP9
20pauciarticular onset juvenile idiopathic arthritis10.2MMP1, MMP9
21gallbladder lymphoma10.2DEFB4A, MMP1
22nervous system cancer10.2DEFB4A, IL1A, MMP9
23benign hypertensive renal disease10.2MMP1, MMP9
24neonatal period electroclinical syndrome10.2IL1A, MMP9
25retinal dystrophies primarily involving bruch's membrane10.2EGF, MMP9
26stromal keratitis10.1MMP1, MMP9
27liver disease10.1ICAM1, IL1A, KRT13
28angioimmunoblastic lymphadenopathy with dysproteinemia10.1DEFB4A, EGF, MMP9
29pulmonary sarcoidosis10.1MMP1, MMP9
30silver-russell syndrome due to 7p11.2p13 microduplication10.1FGF2, TNFSF11
31bone squamous cell carcinoma10.0MMP9, TNFSF11
32lymphangioma10.0IL1A, MMP1, TNFSF11
33xanthomatosis10.0IL1A, MMP1, TNFSF11
34blepharochalasis10.0EGF, MMP9, TNFSF11
35large cell carcinoma with rhabdoid phenotype10.0FGF2, MMP9
36gallbladder papillary carcinoma10.0HIF1A, MMP9
37follicular mucinosis10.0MMP1, MMP9, TNFSF11
38pericardial mesothelioma10.0EGF, FGF2
39chronic interstitial cystitis9.9HIF1A, MMP9
40cholesteatoma9.8
41urticaria9.8EGF, HIF1A, MMP9
42speech disorder9.8FGF2, ICAM1
43pulpitis9.7EGF, MMP9
44chronic rhinitis9.7IL1A, MMP1, MMP9, TNFSF11
45atherosclerosis9.7IL1A, MMP1, MMP9, TNFSF11
46bladder neck cancer9.7FGF2, HIF1A
47granulomatous orchitis9.7FGF2, IL1A, MMP1
48nail disorder, nonsyndromic congenital, 19.6EGF, FGF2, TNFSF11
49neuropathy, hereditary sensory and autonomic, type vi9.6FGF2, ICAM1, MMP9
50lipoid nephrosis9.6DEFB4A, IL1A, KRT13, MMP9, TNFSF11

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to cholesteatoma of middle ear

Symptoms for Cholesteatoma of Middle Ear

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UMLS symptoms related to Cholesteatoma of Middle Ear:


paraesthesia ear, itching of ear, ear congestion, auricular swelling, erythematous ear canal, earache

Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
2Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
3Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
4Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear


Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

35
Testes, Skin

Animal Models for Cholesteatoma of Middle Ear or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, HIF1A, ICAM1, IL1A, MMP9, TNFSF11
2MP:00053698.5FGF2, HIF1A, ICAM1, MMP9, TNFSF11
3MP:00053878.1EGF, HIF1A, ICAM1, IL1A, MMP1, MMP9
4MP:00020068.0FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
5MP:00053917.3EGF, FGF2, HIF1A, ICAM1, MMP9, TNFSF11

Publications for Cholesteatoma of Middle Ear

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Articles related to Cholesteatoma of Middle Ear:

idTitleAuthorsYear
1
Diagnosis of cholesteatoma of middle ear. (13210375)
1954

Variations for Cholesteatoma of Middle Ear

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Expression for genes affiliated with Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for genes affiliated with Cholesteatoma of Middle Ear

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GO Terms for genes affiliated with Cholesteatoma of Middle Ear

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Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.2DEFB4A, EGF, FGF2, ICAM1, IL1A, MMP9
2extracellular regionGO:00055766.9DEFB4A, EGF, FGF2, IL1A, MMP1, MMP9

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:004668810.2ICAM1, IL1A
2positive regulation of DNA bindingGO:004338810.2EGF, MMP9
3connective tissue replacement involved in inflammatory response wound healingGO:000224810.1HIF1A, IL1A
4positive regulation of phosphorylationGO:004232710.1EGF, TNFSF11
5ERK1 and ERK2 cascadeGO:007037110.0EGF, TNFSF11
6mammary gland alveolus developmentGO:00607499.9EGF, TNFSF11
7positive regulation of cerebellar granule cell precursor proliferationGO:00219409.8EGF, FGF2
8positive regulation of vascular endothelial growth factor productionGO:00105759.7HIF1A, IL1A
9positive regulation of mitotic nuclear divisionGO:00458409.7EGF, IL1A
10leukocyte migrationGO:00509009.0ICAM1, MMP1, MMP9
11positive regulation of angiogenesisGO:00457668.9FGF2, HIF1A, IL1A
12positive regulation of MAP kinase activityGO:00434068.9EGF, FGF2, TNFSF11
13angiogenesisGO:00015258.6EGF, FGF2, HIF1A
14extracellular matrix organizationGO:00301988.5FGF2, ICAM1, MMP9

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9FGF2, IL1A, TNFSF11

Sources for Cholesteatoma of Middle Ear

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet