MCID: CHL122
MIFTS: 38

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

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Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 11 13
Middle Ear Cholesteatoma 11 68
Cholesteatoma of Middle Ear and/or Mastoid 11
Cholesteatoma of Middle Ear and Mastoid 11
Cholesteatoma of the Middle Ear 11
Epidermosis of Middle Ear 11
 
Cholesteatoma, Middle Ear 39
Unspecified Cholesteatoma 11
Cholesteatoma Middle Ear 50
Epidermosis of Ear 11
Cholesteatoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:10964
ICD1030 H71
MeSH39 D018424
NCIt45 C3654

Summaries for Cholesteatoma of Middle Ear

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MalaCards based summary: Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to diabetic cataract and pulmonary valve insufficiency, and has symptoms including paraesthesia ear, itching of ear and ear congestion. An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways are a6b1 and a6b4 Integrin signaling and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Affiliated tissues include testes and skin, and related mouse phenotypes are integument and muscle.

Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic cataract10.5IL1A, MMP9
2pulmonary valve insufficiency10.5DEFB4A, IL1A
3uterus carcinoma in situ10.5DEFB4A, IL1A
4chronic rheumatic pericarditis10.4IL1A, TNFSF11
5accessory nerve disease10.4DEFB4A, IL1A
6inflammatory liposarcoma10.4MMP9, TNFSF11
7anaerobic meningitis10.4IL1A, TNFSF11
8malignant giant cell tumor of the tendon sheath10.3MMP9, TNFSF11
9optic atrophy 710.3IL1A, MMP1
10pathological gambling10.3MMP1, MMP9
11classic endocrine tumor of appendix10.3MMP1, MMP9
12atrichia with papular lesions10.3ICAM1, IL1A
13antidepressant or antipsychotic toxicity or dose selection10.3MMP9, TNFSF11
14emphysematous cholecystitis10.3MMP1, MMP9
15mechanical ectropion10.3MMP1, MMP9
16juvenile astrocytoma10.3MMP1, MMP9
17limb reduction defect10.3MMP1, MMP9
18retinal degeneration10.3MMP1, MMP9
19adenosine monophosphate deaminase 1 deficiency10.3MMP1, MMP9
20pauciarticular onset juvenile idiopathic arthritis10.2MMP1, MMP9
21gallbladder lymphoma10.2DEFB4A, MMP1
22nervous system cancer10.2DEFB4A, IL1A, MMP9
23benign hypertensive renal disease10.2MMP1, MMP9
24neonatal period electroclinical syndrome10.2IL1A, MMP9
25retinal dystrophies primarily involving bruch's membrane10.2EGF, MMP9
26stromal keratitis10.1MMP1, MMP9
27liver disease10.1ICAM1, IL1A, KRT13
28angioimmunoblastic lymphadenopathy with dysproteinemia10.1DEFB4A, EGF, MMP9
29pulmonary sarcoidosis10.1MMP1, MMP9
30silver-russell syndrome due to 7p11.2p13 microduplication10.1FGF2, TNFSF11
31bone squamous cell carcinoma10.0MMP9, TNFSF11
32lymphangioma10.0IL1A, MMP1, TNFSF11
33xanthomatosis10.0IL1A, MMP1, TNFSF11
34blepharochalasis10.0EGF, MMP9, TNFSF11
35large cell carcinoma with rhabdoid phenotype10.0FGF2, MMP9
36gallbladder papillary carcinoma10.0HIF1A, MMP9
37follicular mucinosis10.0MMP1, MMP9, TNFSF11
38pericardial mesothelioma10.0EGF, FGF2
39chronic interstitial cystitis9.9HIF1A, MMP9
40cholesteatoma9.8
41urticaria9.8EGF, HIF1A, MMP9
42speech disorder9.8FGF2, ICAM1
43pulpitis9.7EGF, MMP9
44chronic rhinitis9.7IL1A, MMP1, MMP9, TNFSF11
45atherosclerosis9.7IL1A, MMP1, MMP9, TNFSF11
46bladder neck cancer9.7FGF2, HIF1A
47granulomatous orchitis9.7FGF2, IL1A, MMP1
48nail disorder, nonsyndromic congenital, 19.6EGF, FGF2, TNFSF11
49neuropathy, hereditary sensory and autonomic, type vi9.6FGF2, ICAM1, MMP9
50lipoid nephrosis9.6DEFB4A, IL1A, KRT13, MMP9, TNFSF11

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to cholesteatoma of middle ear

Symptoms & Phenotypes for Cholesteatoma of Middle Ear

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UMLS symptoms related to Cholesteatoma of Middle Ear:


paraesthesia ear, itching of ear, ear congestion, auricular swelling, erythematous ear canal, earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, HIF1A, ICAM1, IL1A, MMP9, TNFSF11
2MP:00053698.5FGF2, HIF1A, ICAM1, MMP9, TNFSF11
3MP:00053878.1EGF, HIF1A, ICAM1, IL1A, MMP1, MMP9
4MP:00020068.0FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
5MP:00053917.3EGF, FGF2, HIF1A, ICAM1, MMP9, TNFSF11

Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
2Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
3Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
4Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear


Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

36
Testes, Skin

Publications for Cholesteatoma of Middle Ear

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Articles related to Cholesteatoma of Middle Ear:

idTitleAuthorsYear
1
Diagnosis of cholesteatoma of middle ear. (13210375)
1954

Variations for Cholesteatoma of Middle Ear

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Expression for genes affiliated with Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for genes affiliated with Cholesteatoma of Middle Ear

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GO Terms for genes affiliated with Cholesteatoma of Middle Ear

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Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.0DEFB4A, EGF, FGF2, IL1A, MMP1, MMP9
2extracellular spaceGO:00056157.2DEFB4A, EGF, FGF2, ICAM1, IL1A, MMP9

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.3EGF, TNFSF11
2connective tissue replacement involved in inflammatory response wound healingGO:000224810.2HIF1A, IL1A
3mammary gland alveolus developmentGO:006074910.2EGF, TNFSF11
4positive regulation of DNA bindingGO:004338810.2EGF, MMP9
5positive regulation of mitotic nuclear divisionGO:004584010.2EGF, IL1A
6positive regulation of phosphorylationGO:004232710.0EGF, TNFSF11
7positive regulation of vascular endothelial growth factor productionGO:00105759.9HIF1A, IL1A
8positive regulation of cerebellar granule cell precursor proliferationGO:00219409.8EGF, FGF2
9leukocyte migrationGO:00509009.7ICAM1, MMP1, MMP9
10response to copper ionGO:00466889.7ICAM1, IL1A
11extracellular matrix organizationGO:00301989.4FGF2, ICAM1, MMP9
12positive regulation of angiogenesisGO:00457669.3FGF2, HIF1A, IL1A
13positive regulation of MAP kinase activityGO:00434069.3EGF, FGF2, TNFSF11
14angiogenesisGO:00015259.2EGF, FGF2, HIF1A

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9FGF2, IL1A, TNFSF11

Sources for Cholesteatoma of Middle Ear

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet