MCID: CHL122
MIFTS: 35

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

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Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 11 13
Middle Ear Cholesteatoma 11 68
Cholesteatoma of Middle Ear and/or Mastoid 11
Cholesteatoma of Middle Ear and Mastoid 11
Cholesteatoma of the Middle Ear 11
Epidermosis of Middle Ear 11
 
Cholesteatoma, Middle Ear 39
Unspecified Cholesteatoma 11
Cholesteatoma Middle Ear 50
Epidermosis of Ear 11
Cholesteatoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:10964
ICD1030 H71
MeSH39 D018424
NCIt45 C3654

Summaries for Cholesteatoma of Middle Ear

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MalaCards based summary: Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to toxic optic neuropathy and developmental coordination disorder, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways are a6b1 and a6b4 Integrin signaling and IL1 and megakaryocytes in obesity. Affiliated tissues include skin, and related mouse phenotypes are integument and immune system.

Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1toxic optic neuropathy10.3IL1A, MMP9
2developmental coordination disorder10.2MMP9, TNFSF11
3kleptomania10.2MMP1, MMP9
4adult-onset distal myopathy due to vcp mutation10.2MMP1, MMP9
5senile atrophy of choroid10.1MMP1, MMP9
6ectropion10.1MMP1, MMP9
7malignant giant cell tumor10.1MMP9, TNFSF11
8cystic lymphangioma10.1MMP1, MMP9
9stenosis of lacrimal sac10.1DEFB4A, IL1A, MMP9
10hypotrichosis 410.1ICAM1, IL1A
11linear porokeratosis10.1MMP1, MMP9
12bulbomembranous urethral cancer10.1MMP9, TNFSF11
13lymphedema10.1ICAM1, IL1A, KRT13
14aorta atresia10.1DEFB4A, EGF, MMP9
15cutaneous fibrous histiocytoma10.1DEFB4A, EGF
16adult neuronal ceroid lipofuscinosis10.1MMP1, MMP9
17mast-cell leukemia10.1DEFB4A, ICAM1, KRT13
18visceral steatosis10.1ICAM1, MMP9
19anal paget's disease10.1FGF2, IL1A
20autosomal recessive type iv ehlers-danlos syndrome10.1IL1A, MMP1, TNFSF11
21impotence10.0IL1A, TNFSF11
22plague10.0EGF, MMP9, TNFSF11
23in situ pulmonary adenocarcinoma10.0KRT13, MMP1, MMP9
24bone angioendothelial sarcoma10.0IL1A, MMP1, TNFSF11
25molybdenum cofactor deficiency a10.0IL1A, MMP1, TNFSF11
26onychocytic matricoma10.0MMP1, MMP9
27orofacial granulomatosis10.0ICAM1, IL1A, MMP1
28bladder diffuse clear cell adenocarcinoma10.0EGF, FGF2
29ocular melanoma10.0EGF, KRT13, MMP9
30stomach carcinoma in situ10.0DEFB4A, IL1A
31synovium cancer10.0ICAM1, MMP1, TNFSF11
32diffuse large b-cell lymphoma9.9HIF1A, MMP1, MMP9
33traumatic brain injury9.9HIF1A, MMP1, MMP9
34henoch-schoenlein purpura9.9EGF, HIF1A, ICAM1
35congenital myasthenic syndrome 199.9FGF2, HIF1A
36autistic disorder9.9IL1A, MMP1, MMP9, TNFSF11
37central epithelioid sarcoma9.9FGF2, MMP9
38epidermolysis bullosa simplex, sutosomal recessive 29.9FGF2, ICAM1, MMP9
39vascular dementia9.9DEFB4A, IL1A, KRT13, MMP9, TNFSF11
40glucosephosphate isomerase deficiency9.9EGF, FGF2, MMP9
41optic nerve hypoplasia9.9FGF2, ICAM1, MMP9
42pediatric osteosarcoma9.8FGF2, MMP1, MMP9
43cholesteatoma9.8
44peripheral vascular disease9.8EGF, FGF2, MMP1
45ladd syndrome9.8EGF, FGF2, MMP9
46nevoid hypermelanosis, linear and whorled9.8EGF, FGF2, MMP1
47rheumatoid arthritis9.8ICAM1, IL1A, MMP1, TNFSF11
48histiocytosis9.8DEFB4A, IL1A, MMP1, MMP9, TNFSF11
49intratubular embryonal carcinoma9.8DEFB4A, IL1A, MMP1, MMP9, TNFSF11
50aortic aneurysm, familial thoracic 69.7FGF2, IL1A, MMP1, MMP9

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to cholesteatoma of middle ear

Symptoms & Phenotypes for Cholesteatoma of Middle Ear

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UMLS symptoms related to Cholesteatoma of Middle Ear:


earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5EGF, HIF1A, ICAM1, IL1A, MMP9, TNFSF11
2MP:00053878.1EGF, HIF1A, ICAM1, IL1A, MMP1, MMP9
3MP:00020067.6FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
4MP:00053917.3EGF, FGF2, HIF1A, ICAM1, MMP9, TNFSF11

Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
2Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
3Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
4Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear


Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

36
Skin

Publications for Cholesteatoma of Middle Ear

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Articles related to Cholesteatoma of Middle Ear:

idTitleAuthorsYear
1
Diagnosis of cholesteatoma of middle ear. (13210375)
1954

Variations for Cholesteatoma of Middle Ear

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Expression for genes affiliated with Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for genes affiliated with Cholesteatoma of Middle Ear

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Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.7EGF, IL1A
29.6ICAM1, MMP9
39.6MMP1, MMP9
49.6MMP1, MMP9
59.6MMP1, MMP9
69.3ICAM1, IL1A, MMP9
79.3FGF2, MMP9
89.3ICAM1, IL1A, MMP9
9
Show member pathways
9.2DEFB4A, MMP1, MMP9
109.1EGF, MMP1, MMP9
11
Show member pathways
9.1EGF, MMP1, MMP9
12
Show member pathways
8.9HIF1A, MMP1, TNFSF11
138.8EGF, FGF2, MMP9
148.8EGF, FGF2, TNFSF11
15
Show member pathways
8.8ICAM1, IL1A, MMP1, MMP9
168.7ICAM1, IL1A, MMP1, TNFSF11
17
Show member pathways
8.7FGF2, HIF1A, MMP9
188.7FGF2, HIF1A, MMP9
19
Show member pathways
8.7FGF2, HIF1A, MMP9
20
Show member pathways
8.2FGF2, ICAM1, MMP1, MMP9
217.7EGF, FGF2, HIF1A, MMP1, MMP9
227.3FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
23
Show member pathways
6.4EGF, FGF2, HIF1A, ICAM1, IL1A, MMP1
24
Show member pathways
6.1DEFB4A, EGF, FGF2, HIF1A, ICAM1, IL1A

GO Terms for genes affiliated with Cholesteatoma of Middle Ear

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Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.0DEFB4A, EGF, FGF2, IL1A, MMP1, MMP9
2extracellular spaceGO:00056157.2DEFB4A, EGF, FGF2, ICAM1, IL1A, MMP9

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.3EGF, TNFSF11
2connective tissue replacement involved in inflammatory response wound healingGO:000224810.2HIF1A, IL1A
3mammary gland alveolus developmentGO:006074910.2EGF, TNFSF11
4positive regulation of mitotic nuclear divisionGO:004584010.2EGF, IL1A
5positive regulation of DNA bindingGO:004338810.2EGF, MMP9
6positive regulation of phosphorylationGO:004232710.0EGF, TNFSF11
7positive regulation of vascular endothelial growth factor productionGO:00105759.9HIF1A, IL1A
8leukocyte migrationGO:00509009.7ICAM1, MMP1, MMP9
9response to copper ionGO:00466889.7ICAM1, IL1A
10extracellular matrix organizationGO:00301989.4FGF2, ICAM1, MMP9
11positive regulation of MAP kinase activityGO:00434069.3EGF, FGF2, TNFSF11
12positive regulation of angiogenesisGO:00457669.3FGF2, HIF1A, IL1A
13angiogenesisGO:00015259.3EGF, FGF2, HIF1A

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9FGF2, IL1A, TNFSF11

Sources for Cholesteatoma of Middle Ear

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet