MCID: CHL122
MIFTS: 35

Cholesteatoma of Middle Ear

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

MalaCards integrated aliases for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 12 14
Middle Ear Cholesteatoma 12 69
Cholesteatoma of Middle Ear and/or Mastoid 12
Cholesteatoma of Middle Ear and Mastoid 12
Cholesteatoma of the Middle Ear 12
Epidermosis of Middle Ear 12
Unspecified Cholesteatoma 12
Cholesteatoma, Middle Ear 41
Cholesteatoma Middle Ear 51
Epidermosis of Ear 12
Cholesteatoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10964
ICD10 32 H71
MeSH 41 D018424
NCIt 46 C3654

Summaries for Cholesteatoma of Middle Ear

MalaCards based summary : Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to cholesteatoma and chronic follicular conjunctivitis, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, and related phenotypes are immune system and integument

Related Diseases for Cholesteatoma of Middle Ear

Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 cholesteatoma 29.3 DEFB4A IL1A KRT13 MMP9 TNFSF11
2 chronic follicular conjunctivitis 10.4 IL1A MMP9
3 sebaceous gland disease 10.4 DEFB4A IL1A
4 jaw cancer 10.3 IL1A TNFSF11
5 villonodular synovitis 10.3 MMP9 TNFSF11
6 oral candidiasis 10.3 DEFB4A IL1A
7 leukoplakia 10.3 DEFB4A KRT13
8 periapical periodontitis 10.3 MMP9 TNFSF11
9 periodontitis, aggressive, 1 10.3 IL1A MMP1
10 pigmented villonodular synovitis 10.3 MMP9 TNFSF11
11 folliculitis 10.3 DEFB4A EGF
12 spastic entropion 10.3 MMP1 MMP9
13 chronic actinic dermatitis 10.3 MMP1 MMP9
14 periodontosis 10.3 MMP9 TNFSF11
15 squamous cell carcinoma of the hypopharynx 10.2 MMP1 MMP9
16 internal hemorrhoid 10.2 MMP1 MMP9
17 chromoblastomycosis 10.2 MMP1 MMP9
18 light chain deposition disease 10.2 MMP1 MMP9
19 periodontitis, chronic 10.2 MMP1 TNFSF11
20 root resorption 10.2 IL1A TNFSF11
21 adult astrocytic tumour 10.2 MMP1 MMP9
22 adenomyosis 10.2 MMP1 MMP9
23 keratocystic odontogenic tumor 10.2 MMP9 TNFSF11
24 odontogenic myxoma 10.2 MMP1 MMP9
25 gingivitis 10.2 DEFB4A IL1A MMP9
26 vernal keratoconjunctivitis 10.2 ICAM1 MMP9
27 pelvic organ prolapse 10.1 MMP1 MMP9
28 limbal stem cell deficiency 10.1 ICAM1 IL1A KRT13
29 anal fistula 10.1 DEFB4A EGF MMP9
30 lichen planus 10.0 DEFB4A ICAM1 KRT13
31 bacterial vaginosis 10.0 DEFB4A IL1A
32 chronic venous insufficiency 10.0 ICAM1 MMP1
33 polymyositis 10.0 ICAM1 IL1A
34 bone inflammation disease 10.0 IL1A MMP1 TNFSF11
35 breast adenocarcinoma 10.0 EGF MMP9 TNFSF11
36 psoriatic arthritis 10.0 IL1A MMP1 TNFSF11
37 keratoconus 10.0 IL1A MMP1 MMP9
38 arteriosclerosis obliterans 10.0 HIF1A ICAM1
39 diverticulitis 10.0 FGF2 MMP9
40 oral lichen planus 9.9 ICAM1 IL1A MMP1
41 hypertensive heart disease 9.9 MMP1 MMP9
42 venous insufficiency 9.9 ICAM1 MMP1
43 carotid stenosis 9.9 ICAM1 MMP1 MMP9
44 synovitis 9.8 ICAM1 MMP1 TNFSF11
45 varicose veins 9.8 HIF1A MMP1 MMP9
46 idiopathic hypercalciuria 9.8 FGF2 TNFSF11
47 diabetic macular edema 9.8 FGF2 ICAM1
48 lung cancer susceptibility 3 9.8 EGF HIF1A MMP9
49 nasopharyngeal carcinoma 9.8 HIF1A KRT13 MMP9
50 periodontitis 9.8 IL1A MMP1 MMP9 TNFSF11

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to Cholesteatoma of Middle Ear

Symptoms & Phenotypes for Cholesteatoma of Middle Ear

UMLS symptoms related to Cholesteatoma of Middle Ear:


earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 MMP9 TNFSF11 EGF HIF1A ICAM1 IL1A
2 integument MP:0010771 9.63 TNFSF11 EGF HIF1A ICAM1 IL1A MMP9
3 neoplasm MP:0002006 9.5 TNFSF11 FGF2 HIF1A ICAM1 IL1A MMP1
4 vision/eye MP:0005391 9.1 TNFSF11 EGF FGF2 HIF1A ICAM1 MMP9

Drugs & Therapeutics for Cholesteatoma of Middle Ear

Search Clinical Trials , NIH Clinical Center for Cholesteatoma of Middle Ear

Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

Anatomical Context for Cholesteatoma of Middle Ear

MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

38
Skin

Publications for Cholesteatoma of Middle Ear

Articles related to Cholesteatoma of Middle Ear:

# Title Authors Year
1
Diagnosis of cholesteatoma of middle ear. ( 13210375 )
1954

Variations for Cholesteatoma of Middle Ear

Expression for Cholesteatoma of Middle Ear

Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for Cholesteatoma of Middle Ear

Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 DEFB4A EGF FGF2 HIF1A ICAM1 IL1A
2
Show member pathways
12.67 EGF FGF2 HIF1A ICAM1 IL1A MMP1
3 12.55 EGF FGF2 HIF1A MMP1 MMP9
4
Show member pathways
12.51 FGF2 ICAM1 MMP1 MMP9
5
Show member pathways
12.33 FGF2 HIF1A ICAM1 MMP9
6
Show member pathways
12.12 DEFB4A MMP1 MMP9
7 12.07 FGF2 HIF1A MMP9
8
Show member pathways
12.05 HIF1A MMP1 TNFSF11
9 11.96 EGF MMP1 MMP9
10 11.87 ICAM1 IL1A MMP9
11 11.78 ICAM1 IL1A MMP9
12 11.62 FGF2 HIF1A MMP9
13 11.52 EGF MMP1 MMP9
14 11.51 ICAM1 IL1A MMP1 TNFSF11
15 11.43 EGF FGF2 MMP9
16 11.26 EGF FGF2
17 11.26 EGF FGF2 TNFSF11
18
Show member pathways
11.26 ICAM1 IL1A MMP1 MMP9
19 11.22 MMP1 MMP9
20 11.16 FGF2 HIF1A ICAM1 IL1A MMP1 MMP9
21 11.15 MMP1 MMP9
22 11.1 EGF IL1A
23 11.09 FGF2 MMP9
24 10.97 ICAM1 MMP9
25 10.88 FGF2 HIF1A MMP9
26 10.79 EGF FGF2 IL1A TNFSF11
27 10.77 MMP1 MMP9

GO Terms for Cholesteatoma of Middle Ear

Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 DEFB4A EGF FGF2 IL1A MMP1 MMP9
2 extracellular space GO:0005615 9.17 DEFB4A EGF FGF2 ICAM1 IL1A MMP9

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.72 EGF FGF2 HIF1A
2 leukocyte migration GO:0050900 9.7 ICAM1 MMP1 MMP9
3 extracellular matrix organization GO:0030198 9.67 FGF2 ICAM1 MMP9
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.54 FGF2 HIF1A
5 positive regulation of protein kinase B signaling GO:0051897 9.54 EGF FGF2 TNFSF11
6 positive regulation of phosphorylation GO:0042327 9.51 EGF TNFSF11
7 ERK1 and ERK2 cascade GO:0070371 9.48 EGF TNFSF11
8 positive regulation of DNA binding GO:0043388 9.46 EGF MMP9
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.43 HIF1A IL1A
10 positive regulation of angiogenesis GO:0045766 9.43 FGF2 HIF1A IL1A
11 positive regulation of mitotic nuclear division GO:0045840 9.4 EGF IL1A
12 mammary gland alveolus development GO:0060749 9.32 EGF TNFSF11
13 response to copper ion GO:0046688 9.16 ICAM1 IL1A
14 positive regulation of MAP kinase activity GO:0043406 9.13 EGF FGF2 TNFSF11
15 connective tissue replacement involved in inflammatory response wound healing GO:0002248 8.62 HIF1A IL1A

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 FGF2 IL1A TNFSF11

Sources for Cholesteatoma of Middle Ear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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