MCID: CHL122
MIFTS: 32

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

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Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 11 13
Middle Ear Cholesteatoma 11 66
Cholesteatoma of Middle Ear and/or Mastoid 11
Cholesteatoma of Middle Ear and Mastoid 11
Cholesteatoma of the Middle Ear 11
Epidermosis of Middle Ear 11
 
Cholesteatoma, Middle Ear 37
Unspecified Cholesteatoma 11
Cholesteatoma Middle Ear 48
Epidermosis of Ear 11
Cholesteatoma 66

Classifications:



External Ids:

Disease Ontology11 DOID:10964
ICD1028 H71
MeSH37 D018424
NCIt43 C3654

Summaries for Cholesteatoma of Middle Ear

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MalaCards based summary: Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to rectosigmoid junction neoplasm and pulmonary valve insufficiency, and has symptoms including earache, erythematous ear canal and auricular swelling. An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and FGF signaling pathway. Affiliated tissues include testes and skin, and related mouse phenotypes are integument and behavior/neurological.

Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1rectosigmoid junction neoplasm10.5IL1A, KRT16
2pulmonary valve insufficiency10.4DEFB4A, IL1A
3uterus carcinoma in situ10.4DEFB4A, IL1A
4otosclerosis10.4DEFB4A, KRT16
5accessory nerve disease10.4DEFB4A, IL1A
6liver disease10.3IL1A, KRT13
7chronic rheumatic pericarditis10.2IL1A, TNFSF11
8anaerobic meningitis10.2IL1A, TNFSF11
9epidermolysis bullosa simplex, dowling-meara type10.2KRT13, KRT16
10lung sarcoma10.2IL1A, KRT16
11lymphangioma10.1IL1A, TNFSF11
12diabetic cataract10.1IL1A, MMP9
13pleomorphic lipoma10.1IL1A, TNFSF11
14lissencephaly10.0KRT13, KRT16
15neonatal period electroclinical syndrome10.0IL1A, MMP9
16cholesteatoma10.0
17angioimmunoblastic lymphadenopathy with dysproteinemia10.0DEFB4A, MMP9
18intervertebral disc disease9.9IL1A, MMP9
19xanthomatosis9.8IL1A, TNFSF11
20follicular mucinosis9.8MMP9, TNFSF11
21inflammatory liposarcoma9.8MMP9, TNFSF11
22malignant giant cell tumor of the tendon sheath9.8MMP9, TNFSF11
23antidepressant or antipsychotic toxicity or dose selection9.7MMP9, TNFSF11
24bone squamous cell carcinoma9.7MMP9, TNFSF11
25hodgkin's granuloma9.7KRT13, MMP9
26nervous system cancer9.7DEFB4A, IL1A, MMP9
27neuroma9.6MMP9, TNFSF11
28chronic rhinitis9.5IL1A, MMP9, TNFSF11
29atherosclerosis9.5IL1A, MMP9, TNFSF11
30malignant giant cell tumor9.4MMP9, TNFSF11
31cannabis dependence9.4MMP9, TNFSF11
32blepharochalasis9.1MMP9, TNFSF11
33palmoplantar keratosis9.1DEFB4A, IL1A, MMP9, TNFSF11
34subacute monocytic leukemia7.5DEFB4A, FGFR2, IL1A, KRT13, KRT16, LGALS8
35lipoid nephrosis7.0DEFB4A, FGFR2, IL1A, KRT13, KRT16, LGALS8

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to cholesteatoma of middle ear

Symptoms for Cholesteatoma of Middle Ear

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UMLS symptoms related to Cholesteatoma of Middle Ear:


earache, erythematous ear canal, auricular swelling, ear congestion, itching of ear, paraesthesia ear

Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
2Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
3Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of CholesteatomasRecruitingNCT02903550
4Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear


Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

34
Testes, Skin

Animal Models for Cholesteatoma of Middle Ear or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1FGFR2, IL1A, KRT16, MMP9, TNFSF11
2MP:00053867.4FGFR2, KRT16, LGALS8, MARVELD2, MMP9, TNFSF11

Publications for Cholesteatoma of Middle Ear

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Articles related to Cholesteatoma of Middle Ear:

idTitleAuthorsYear
1
Diagnosis of cholesteatoma of middle ear. (13210375)
1954

Variations for Cholesteatoma of Middle Ear

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Expression for genes affiliated with Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for genes affiliated with Cholesteatoma of Middle Ear

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Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5IL1A, TNFSF11
29.3FGFR2, MMP9
3
Show member pathways
9.3FGFR2, MMP9

GO Terms for genes affiliated with Cholesteatoma of Middle Ear

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Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.9DEFB4A, IL1A, LGALS8, MMP9, TNFSF11
2extracellular regionGO:00055767.6DEFB4A, FGFR2, IL1A, MMP9, TNFSF11

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell divisionGO:005178110.2FGFR2, IL1A
2positive regulation of JNK cascadeGO:00463309.7IL1A, TNFSF11
3immune responseGO:00069559.1DEFB4A, IL1A, TNFSF11

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.1DEFB4A, FGFR2, IL1A, KRT13, KRT16, LGALS8

Sources for Cholesteatoma of Middle Ear

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet