MCID: CHL122
MIFTS: 35

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 12 14
Middle Ear Cholesteatoma 12 69
Cholesteatoma of Middle Ear and/or Mastoid 12
Cholesteatoma of Middle Ear and Mastoid 12
Cholesteatoma of the Middle Ear 12
Epidermosis of Middle Ear 12
Unspecified Cholesteatoma 12
Cholesteatoma, Middle Ear 42
Cholesteatoma Middle Ear 52
Epidermosis of Ear 12
Cholesteatoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10964
ICD10 33 H71
MeSH 42 D018424
NCIt 47 C3654

Summaries for Cholesteatoma of Middle Ear

MalaCards based summary : Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to toxic optic neuropathy and developmental coordination disorder, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, and related phenotypes are immune system and integument

Related Diseases for Cholesteatoma of Middle Ear

Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 toxic optic neuropathy 10.3 IL1A MMP9
2 developmental coordination disorder 10.2 MMP9 TNFSF11
3 kleptomania 10.2 MMP1 MMP9
4 adult-onset distal myopathy due to vcp mutation 10.2 MMP1 MMP9
5 senile atrophy of choroid 10.1 MMP1 MMP9
6 ectropion 10.1 MMP1 MMP9
7 malignant giant cell tumor 10.1 MMP9 TNFSF11
8 cystic lymphangioma 10.1 MMP1 MMP9
9 stenosis of lacrimal sac 10.1 DEFB4A IL1A MMP9
10 hypotrichosis 4 10.1 ICAM1 IL1A
11 linear porokeratosis 10.1 MMP1 MMP9
12 bulbomembranous urethral cancer 10.1 MMP9 TNFSF11
13 lymphedema 10.1 ICAM1 IL1A KRT13
14 aorta atresia 10.1 DEFB4A EGF MMP9
15 cutaneous fibrous histiocytoma 10.1 DEFB4A EGF
16 adult neuronal ceroid lipofuscinosis 10.1 MMP1 MMP9
17 mast-cell leukemia 10.1 DEFB4A ICAM1 KRT13
18 visceral steatosis 10.1 ICAM1 MMP9
19 anal paget's disease 10.1 FGF2 IL1A
20 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1A MMP1 TNFSF11
21 impotence 10.0 IL1A TNFSF11
22 plague 10.0 EGF MMP9 TNFSF11
23 in situ pulmonary adenocarcinoma 10.0 KRT13 MMP1 MMP9
24 bone angioendothelial sarcoma 10.0 IL1A MMP1 TNFSF11
25 molybdenum cofactor deficiency a 10.0 IL1A MMP1 TNFSF11
26 onychocytic matricoma 10.0 MMP1 MMP9
27 orofacial granulomatosis 10.0 ICAM1 IL1A MMP1
28 bladder diffuse clear cell adenocarcinoma 10.0 EGF FGF2
29 ocular melanoma 10.0 EGF KRT13 MMP9
30 stomach carcinoma in situ 10.0 DEFB4A IL1A
31 synovium cancer 10.0 ICAM1 MMP1 TNFSF11
32 diffuse large b-cell lymphoma 9.9 HIF1A MMP1 MMP9
33 traumatic brain injury 9.9 HIF1A MMP1 MMP9
34 henoch-schoenlein purpura 9.9 EGF HIF1A ICAM1
35 congenital myasthenic syndrome 19 9.9 FGF2 HIF1A
36 autistic disorder 9.9 IL1A MMP1 MMP9 TNFSF11
37 central epithelioid sarcoma 9.9 FGF2 MMP9
38 epidermolysis bullosa simplex, sutosomal recessive 2 9.9 FGF2 ICAM1 MMP9
39 vascular dementia 9.9 DEFB4A IL1A KRT13 MMP9 TNFSF11
40 glucosephosphate isomerase deficiency 9.9 EGF FGF2 MMP9
41 optic nerve hypoplasia 9.9 FGF2 ICAM1 MMP9
42 pediatric osteosarcoma 9.8 FGF2 MMP1 MMP9
43 cholesteatoma 9.8
44 peripheral vascular disease 9.8 EGF FGF2 MMP1
45 ladd syndrome 9.8 EGF FGF2 MMP9
46 nevoid hypermelanosis, linear and whorled 9.8 EGF FGF2 MMP1
47 rheumatoid arthritis 9.8 ICAM1 IL1A MMP1 TNFSF11
48 histiocytosis 9.8 DEFB4A IL1A MMP1 MMP9 TNFSF11
49 intratubular embryonal carcinoma 9.8 DEFB4A IL1A MMP1 MMP9 TNFSF11
50 aortic aneurysm, familial thoracic 6 9.7 FGF2 IL1A MMP1 MMP9

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to Cholesteatoma of Middle Ear

Symptoms & Phenotypes for Cholesteatoma of Middle Ear

UMLS symptoms related to Cholesteatoma of Middle Ear:


earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 EGF HIF1A ICAM1 IL1A MMP1 MMP9
2 integument MP:0010771 9.63 EGF HIF1A ICAM1 IL1A MMP9 TNFSF11
3 neoplasm MP:0002006 9.5 FGF2 HIF1A ICAM1 IL1A MMP1 MMP9
4 vision/eye MP:0005391 9.1 EGF FGF2 HIF1A ICAM1 MMP9 TNFSF11

Drugs & Therapeutics for Cholesteatoma of Middle Ear

Interventional clinical trials:


id Name Status NCT ID Phase
1 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
2 Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively Completed NCT02554422
3 Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas Recruiting NCT02903550
4 Comprehensive Wide Bandwidth Test Battery of Auditory Function in Veterans Enrolling by invitation NCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear

Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

Anatomical Context for Cholesteatoma of Middle Ear

MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

39
Skin

Publications for Cholesteatoma of Middle Ear

Articles related to Cholesteatoma of Middle Ear:

id Title Authors Year
1
Diagnosis of cholesteatoma of middle ear. ( 13210375 )
1954

Variations for Cholesteatoma of Middle Ear

Expression for Cholesteatoma of Middle Ear

Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for Cholesteatoma of Middle Ear

Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 DEFB4A EGF FGF2 HIF1A ICAM1 IL1A
2
Show member pathways
12.67 EGF FGF2 HIF1A ICAM1 IL1A MMP1
3
Show member pathways
12.5 FGF2 ICAM1 MMP1 MMP9
4 12.36 EGF FGF2 HIF1A MMP1 MMP9
5
Show member pathways
12.11 DEFB4A MMP1 MMP9
6 12.06 FGF2 HIF1A MMP9
7
Show member pathways
12.04 HIF1A MMP1 TNFSF11
8 11.95 EGF MMP1 MMP9
9 11.86 ICAM1 IL1A MMP9
10 11.77 ICAM1 IL1A MMP9
11 11.61 FGF2 HIF1A MMP9
12 11.52 EGF MMP1 MMP9
13 11.51 ICAM1 IL1A MMP1 TNFSF11
14 11.43 EGF FGF2 MMP9
15 11.29 EGF FGF2 TNFSF11
16
Show member pathways
11.26 ICAM1 IL1A MMP1 MMP9
17 11.21 MMP1 MMP9
18 11.16 FGF2 HIF1A ICAM1 IL1A MMP1 MMP9
19 11.14 MMP1 MMP9
20 11.08 EGF IL1A
21 11.08 FGF2 MMP9
22 10.97 ICAM1 MMP9
23 10.88 FGF2 HIF1A MMP9
24 10.75 MMP1 MMP9

GO Terms for Cholesteatoma of Middle Ear

Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 DEFB4A EGF FGF2 IL1A MMP1 MMP9
2 extracellular space GO:0005615 9.17 DEFB4A EGF FGF2 ICAM1 IL1A MMP9

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.7 EGF FGF2 HIF1A
2 leukocyte migration GO:0050900 9.69 ICAM1 MMP1 MMP9
3 extracellular matrix organization GO:0030198 9.67 FGF2 ICAM1 MMP9
4 positive regulation of phosphorylation GO:0042327 9.48 EGF TNFSF11
5 positive regulation of DNA binding GO:0043388 9.46 EGF MMP9
6 ERK1 and ERK2 cascade GO:0070371 9.43 EGF TNFSF11
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.4 HIF1A IL1A
8 positive regulation of mitotic nuclear division GO:0045840 9.37 EGF IL1A
9 positive regulation of angiogenesis GO:0045766 9.33 FGF2 HIF1A IL1A
10 mammary gland alveolus development GO:0060749 9.32 EGF TNFSF11
11 response to copper ion GO:0046688 9.26 ICAM1 IL1A
12 positive regulation of MAP kinase activity GO:0043406 9.13 EGF FGF2 TNFSF11
13 connective tissue replacement involved in inflammatory response wound healing GO:0002248 8.62 HIF1A IL1A

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 FGF2 IL1A TNFSF11

Sources for Cholesteatoma of Middle Ear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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