MCID: CHL122
MIFTS: 28

Cholesteatoma of Middle Ear malady

Categories: Ear diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

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Aliases & Descriptions for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 10 12
Middle Ear Cholesteatoma 10 65
Cholesteatoma of Middle Ear and/or Mastoid 10
Cholesteatoma of Middle Ear and Mastoid 10
Cholesteatoma of the Middle Ear 10
Epidermosis of Middle Ear 10
 
Cholesteatoma, Middle Ear 36
Unspecified Cholesteatoma 10
Cholesteatoma Middle Ear 47
Epidermosis of Ear 10
Cholesteatoma 65

Classifications:



External Ids:

Disease Ontology10 DOID:10964
ICD1027 H71
ICD9CM29 385.32, 385.33
MeSH36 D018424
NCIt42 C3654
UMLS65 C0008374, C0155490

Summaries for Cholesteatoma of Middle Ear

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MalaCards based summary: Cholesteatoma of Middle Ear, also known as middle ear cholesteatoma, is related to neuronitis and anatomical narrow angle borderline glaucoma. An important gene associated with Cholesteatoma of Middle Ear is IL1A (Interleukin 1 Alpha), and among its related pathways are a6b1 and a6b4 Integrin signaling and Cell adhesion_Cell-matrix glycoconjugates. Affiliated tissues include testes and skin, and related mouse phenotypes are integument and vision/eye.

Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1neuronitis10.5
2anatomical narrow angle borderline glaucoma10.4IL1A, MMP9
3posterior amorphous corneal dystrophy10.3EGF, IL1A
4anaplastic large cell lymphoma10.3EGF, MMP9
5intervertebral disc disease10.2IL1A, MMP9
6entropion10.2MMP1, MMP9
7ganglion or cyst of synovium/tendon/bursa10.2MMP1, MMP9
8henoch-schoenlein purpura10.2IL1A, MMP1
9conjunctival disease10.2MMP1, MMP9
10meibomian cyst10.2MMP1, MMP9
11grade iii astrocytoma10.2MMP1, MMP9
12synovitis10.2MMP1, MMP9
13colorectal cancer10.2
14breast cancer10.2
15herpes gestationis10.2
16cavernous sinus thrombosis10.2
17odontoma10.2MMP1, MMP9
18funisitis10.2IL1A, MMP9
19flat retinoschisis10.2MMP1, MMP9
20leishmaniasis10.2
21mucocutaneous leishmaniasis10.2
22abnormal pupillary function10.1MMP1, MMP9
23morbid obesity10.1MMP1, MMP9
24foster-kennedy syndrome10.1IL1A, MMP9, TNFSF11
25mycobacterium kansasii10.1
26mycobacterium marinum10.1
27right aortic arch10.1
28polyneuropathy mental retardation acromicria premature menopause10.1ICAM1, IL1A
29thrombocytopenia10.1ICAM1, MMP9
30accessory nerve disease10.1IL1A, MMP9, TNFSF11
31umbilical hernia10.1MMP1, MMP9
32pulmonary fibrosis10.1MMP1, MMP9
33miliary tuberculosis10.1ICAM1, IL1A
34glycoproteinosis10.1IL1A, MMP1, TNFSF11
35bone ameloblastoma10.1MMP9, TNFSF11
36breast disease10.0EGF, MMP9, TNFSF11
37leprosy 410.0IL1A, MMP1, TNFSF11
38liver cirrhosis10.0ICAM1, IL1A, KRT13
39methylmalonic acidemia10.0IL1A, MMP1
40duodenal somatostatinoma10.0FGF2, MMP9
41psychologic dyspareunia10.0EGF, HIF1A, MMP9
42gingivitis10.0IL1A, MMP1
43vibratory urticaria9.9EGF, HIF1A, MMP9
44myeloid leukemia9.9IL1A, KRT13, MMP9, TNFSF11
45zimmermann-laband syndrome 29.9EGF, HIF1A, MMP9
46oral pharyngeal disorders9.9ICAM1, IL1A, MMP1
47mansonelliasis9.9EGF, FGF2
48granulomatous orchitis9.9IL1A, MMP9
49large intestine adenocarcinoma9.9FGF2, HIF1A
50orbital plasma cell granuloma9.9ICAM1, MMP1

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to cholesteatoma of middle ear

Symptoms for Cholesteatoma of Middle Ear

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Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
2Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
3Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Cholesteatoma of Middle Ear


Cochrane evidence based reviews: cholesteatoma, middle ear

Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

33
Testes, Skin

Animal Models for Cholesteatoma of Middle Ear or affiliated genes

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MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0EGF, HIF1A, ICAM1, IL1A, MMP9, TNFSF11
2MP:00053917.8EGF, FGF2, HIF1A, ICAM1, MMP9
3MP:00020067.5FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
4MP:00053697.4FGF2, HIF1A, ICAM1, MMP9, TNFSF11
5MP:00053877.2EGF, HIF1A, ICAM1, IL1A, MMP1, MMP9
6MP:00053766.8FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9

Publications for Cholesteatoma of Middle Ear

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Variations for Cholesteatoma of Middle Ear

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Expression for genes affiliated with Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for genes affiliated with Cholesteatoma of Middle Ear

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GO Terms for genes affiliated with Cholesteatoma of Middle Ear

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Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor productionGO:001057510.1HIF1A, IL1A
2positive regulation of phosphorylationGO:004232710.1EGF, TNFSF11
3positive regulation of cerebellar granule cell precursor proliferationGO:00219409.8EGF, FGF2
4positive regulation of MAP kinase activityGO:00434069.8FGF2, TNFSF11
5phosphatidylinositol phosphorylationGO:00468549.6EGF, FGF2
6cytokine-mediated signaling pathwayGO:00192219.6ICAM1, IL1A, TNFSF11
7cellular response to glucose stimulusGO:00713339.5HIF1A, ICAM1
8positive regulation of gene expressionGO:00106288.8FGF2, HIF1A, IL1A
9positive regulation of GTPase activityGO:00435478.6EGF, FGF2, ICAM1
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.1FGF2, HIF1A, IL1A, TNFSF11

Sources for Cholesteatoma of Middle Ear

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet