Summaries for Cholesterol

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23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Cholesterol is a waxy, fat-like substance that occurs naturally in all parts of the body. your body needs some cholesterol to work properly. but if you have too much in your blood, it can stick to the walls of your arteries. this is called plaque. plaque can narrow your arteries or even block them. high levels of cholesterol in the blood can increase your risk of heart disease. your cholesterol levels tend to rise as you get older. there are usually no signs or symptoms that you have high blood cholesterol, but it can be detected with a blood test. you are likely to have high cholesterol if members of your family have it, if you are overweight or if you eat a lot of fatty foods. you can lower your cholesterol by exercising more and eating more fruits and vegetables. you also may need to take medicine to lower your cholesterol. nih: national heart, lung, and blood institute23

MalaCards: Cholesterol is related to carcinoma and neuronitis. An important gene associated with Cholesterol is SOAT2 (sterol O-acyltransferase 2), and among its related pathways are Molecular Mechanisms of Cancer and p38 Signaling. The compounds atp and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are cellular and cardiovascular system.

CDC: Having high blood cholesterol puts you at risk for heart disease, the leading cause of death in the United States. About 1 of every 6 adult Americans has high blood cholesterol.12

Wikipedia: Cholesterol, from the Greek chole- (bile) and stereos (solid) followed by the chemical suffix -ol for an...44 more...

Aliases & Descriptions for Cholesterol

Sources:
17Genetics Home Reference, 23MedlinePlus, 2CDC
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cholesterol 17 23

Related Diseases for Cholesterol

Sources:
13GeneCards, 14GeneDecks
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Diseases related to cholesterol by text searches and GeneDecks gene sharing:

(show top 50)    (show all 898)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma215.0ZNF202, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
2neuronitis184.4ZNF259, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
3prostatitis172.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
4pancreatitis157.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
5leukemia154.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIAS1
6alzheimer's disease136.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIK3C3
7adenocarcinoma133.9PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIK3C3
8obesity133.0PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
9atherosclerosis132.1ZNF202, PIK3C2A, PIK3CG, LRP1, LRP2, LRP5
10thyroiditis130.0PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1B
11hepatocellular carcinoma121.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KL
12diabetes mellitus119.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
13hypertension119.0PIK3CB, PIK3R1, PIK3C2B, PIK3C2A, PIK3CG, LRP1
14cerebritis109.4PIK3R1, PIK3C2A, PIK3CG, LRP1, LRP2, LRP6
15melanoma106.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
16insulin resistance106.4PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
17ovarian cancer103.5PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
18fibrosis102.2PIK3CA, PIK3CG, LRP1, KL, NCF2, NCOA3
19arthritis100.9PIK3CD, PIK3CG, LRP1, LRP2, LRP5, KL
20neuroblastoma96.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
21retinitis96.4PIK3CA, PIK3C2A, PIK3CG, LRAT, LRP1, LRP2
22schizophrenia96.4PIK3CB, PIK3CA, PIK3R1, PIK3C2G, PIK3CG, PIK3C3
23myocardial infarction95.5PIK3C2A, PIK3CG, LRP1, LRP8, LRPAP1, COG2
24colon cancer95.3PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, LRP6
25rheumatoid arthritis93.3PIK3CD, PIK3CG, LRP1, LRP2, LRP5, KL
26ischemia92.2PIK3CA, PIK3C2A, PIK3CG, COG2, RELA, REN
27breast carcinoma91.1ZNF202, PIK3CA, PIK3R1, PIK3CG, LRP1, LRPAP1
28coronary heart disease90.9ZNF568, ZNF202, PIK3C2A, LRP1, LRP5, COG2
29adenoma87.9PIK3CA, NCF2, NCOA1, NCOA2, NCOA3, NCOR1
30hepatitis b83.8PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCF2, NCOA6
31asthma81.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
32nephropathy80.8LRP1, LRP2, LRPAP1, COG2, REG1A, RELA
33gonococcal synovitis78.9PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, NCOA1
34colorectal cancer78.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
35peritonitis77.7PIK3C2A, LRP1, LRPAP1, COG2, PDE3B, REG1A
36pneumonia77.4PIK3C2A, COG2, KL, KLB, RELA, VTN
37cystic fibrosis75.9PIK3CG, RECK, REG1A, REN, SGK1, WASL
38lupus erythematosus75.2PIK3CD, PIK3C2A, PIK3CG, LRP2, COG2, NCF2
39dementia73.9PIK3C2A, PIK3CG, LRP1, LRP8, LRPAP1, NCOA6
40hypercholesterolemia72.9PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
41hyperlipidemia71.6PIK3CB, PIK3C2A, PIK3CG, LRP1, COG2, RETN
42type 2 diabetes mellitus70.1PIK3R1, COG2, PDE3B, RECK, RETN, SGK1
43blindness69.5PIK3C2A, PIK3CG, LRAT, LRP5, COG2, REN
44colon carcinoma67.0PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1, PIK3CG
45hypoxia65.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
46ovarian carcinoma65.1PIK3CA, PIK3CG, NDN, NCOA3, RECK, REL
47acute myocardial infarction64.6PIK3C2A, PIK3CG, COG2, REN, RETN, KITLG
48essential hypertension64.0PIK3C2B, COG2, REN, RETN, SGK1, VWF
49squamous cell carcinoma63.3PIK3CB, PIK3CA, LRP1B, LRAT, NCOA3, RECK
50neurodegeneration63.1ZNF259, PIK3CB, PIK3CG, PIK3C3, LRP1, LRP2

Graphical network of the top 20 diseases related to cholesterol:



Graphical network of diseases related to cholesterol

Clinical Features for Cholesterol

Drugs & Therapeutics for Cholesterol

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
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Approved drugs:

Search CenterWatch for cholesterol

Drug clinical trials:

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Genetic Tests for Cholesterol

Anatomical Context for Cholesterol

Sources:
22MalaCards
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MalaCards organs/tissues related to cholesterol:

22
Bone marrow, Whole blood, Lymph node, Spleen, Brain, Cortex, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Placenta, Prostate, Testis, Cervix, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Temporal lobe, Pons, Cardiac myocytes, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary, Testis leydig

Phenotypes for genes affiliated with Cholesterol

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25MGI
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MGI Mouse Phenotypes related to cholesterol:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538468.2ZNF259, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG
2cardiovascular system phenotypeMP:000538565.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
3behavior/neurological phenotypeMP:000538660.9PIK3CA, PIK3C3, LRP4, LRP1, LRP2, LRP5
4immune system phenotypeMP:000538755.4PIK3CD, PIAS1, PIK3C3, LRP1, LRP5, KL
5nervous system phenotypeMP:000363154.1LRP4, LRAT, LRP1, LRP5, LRP6, LRP8
6muscle phenotypeMP:000536944.8PIK3CA, PIK3R2, PIK3R1, PIK3CG, PIK3C3, LRP1
7normal phenotypeMP:000287342.6PIK3R1, PIK3C3, LRP1B, LRP1, LRP5, LRP6
8liver/biliary system phenotypeMP:000537042.4PIK3C3, LRP5, LRP6, KLB, NCOA3, NCOA6
9integument phenotypeMP:001077136.8PIK3C2B, PIK3CG, LRP4, LRP6, KL, NDN
10digestive/alimentary phenotypeMP:000538136.8LRP2, LRP6, KL, KLF5, NCOA3, NCOA6
11vision/eye phenotypeMP:000539135.3PIK3CA, LRAT, LRP2, LRP5, LRP6, NCOA6
12renal/urinary system phenotypeMP:000536734.5LRP4, LRP2, LRP6, LRPAP1, KL, NCOA1
13adipose tissue phenotypeMP:000537533.9PIK3CA, PIK3R1, PIK3C2A, LRP1, LRP6, KL
14embryogenesis phenotypeMP:000538031.7ZNF259, PIK3CB, PIK3CA, PIK3C3, LRP4, LRP5
15skeleton phenotypeMP:000539030.5PIK3CD, PIK3CG, LRP4, LRP1, LRP2, LRP6
16no phenotypic analysisMP:000301227.5PIK3CD, PIK3R1, PIK3C2B, LRP2, LRP6, NDN
17respiratory system phenotypeMP:000538827.0LRP4, LRP2, LRP6, KL, KLF5, NDN
18endocrine/exocrine gland phenotypeMP:000537925.4LRP4, LRP2, LRP5, LRPAP1, KL, KLB
19tumorigenesisMP:000200625.0PIK3CB, PIK3CA, PIK3R2, PIK3R1, KLF11, NCOA3
20craniofacial phenotypeMP:000538224.5LRP4, LRP2, LRP5, LRP6, NCOA3, NCOA6
21limbs/digits/tail phenotypeMP:000537123.0LRP4, LRP5, LRP6, KL, NCOA6, RECK
22hearing/vestibular/ear phenotypeMP:000537719.2LRP2, LRP6, NCOA3, KITLG, RB1, NAGLU
23other phenotypeMP:000539517.4LRPAP1, KL, RECK, RELB, CNR1, RBP2
24pigmentation phenotypeMP:000118616.5LRP5, NCOA6, PDE3B, KITLG, RB1, SERPINC1
25hematopoietic system phenotypeMP:000539710.7SEPT5, TBXAS1
26homeostasis/metabolism phenotypeMP:0005376INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
27growth/size phenotypeMP:0005378INFPIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3C2A, PIK3CG
28mortality/agingMP:0010768INFZNF259, PIK3CB, PIK3CA, PIAS1, PIK3C2A, PIK3C3
29reproductive system phenotypeMP:0005389INFPIK3CA, LRP4, LRAT, LRP6, LRP8, LRPAP1

Publications for genes affiliated with Cholesterol

Sources:
35PubMed
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Articles related to cholesterol:

(show top 50)    (show all 4239)
idTitleAuthorsYearAffiliating Genes
1Atorvastatin treatment lowers fasting remnant-like pa rticle cholesterol and LDL subfraction cholesterol without affecting LDL size i n type 2 diabetes mellitus: Relevance for non-HDL cholesterol and apolipoprotei n B guideline targets. (19800983)Kappelle P.J.... Dullaart R.P.2010APOB
2Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammat ion. (20668705)RajamAoki K.... Eklund K.K.2010NLRP3
3The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene. (19364639)Junyent M.... Ordovas J.M.2009CETP
4Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes. (19605528)Pipe E.A.... Duncan A.M.2009APOA1, APOB
5Statin therapy alters the relationship between apolipoprotein B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients: the MERCURY II (Measuring Effective Reductions in Cholesterol Using Rosuvastatin) trial. (18702965)Ballantyne C.M.... Cain V.A.2008APOB
6Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior. (18203892)Pond W.G.... Smith E.O.2008CYP7A1
7Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol. (18298826)Kolz M.... Illig T.2008TLR4
8Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol. (19013286)Chan J.... Vandeberg J.L.2008ABCG5, ABCG8
9Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol. (18708743)Balijepalli R.C.... January C.T.2007KCNH2, KCNE2, KCNV2
10Immobilization of cholesterol esterase and cholesterol oxidase onto sol-gel films for application to cholesterol biosensor. (17386511)Singh S.... Malhotra B.D.2007CEL
11Regulation of hepatic cholesterol metabolism in CETP/LDLr mice by cholesterol feeding and by drugs (cholestyramine and lovastatin) that lower plasma cholesterol. (17184503)Harada L.M.... Quintao E.C.2006CYP27A1, NR1H3, CETP
12Putting cholesterol in its place: apoE and reverse cholesterol transport. (16670767)Mahley R.W.... Weisgraber K.H.2006APOE, CETP
13AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. (16801347)Spencer-Jones N.J.... O'Dell S.D.2006PRKAA2
14Achieving LDL cholesterol, non-HDL cholesterol, and apolipoprotein B target levels in high-risk patients: Measuring Effective Reductions in Cholesterol Using Rosuvastatin therapY (MERCURY) II. (16644314)Ballantyne C.M.... Raichlen J.S.2006APOB
15Covalent immobilization of cholesterol esterase and cholesterol oxidase on polyaniline films for application to cholesterol biosensor. (17761252)Singh S.... Malhotra B.D.2006CEL
16Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. (15961705)Forcheron F.... Beylot M.2005ABCA1, CD36, HMGCR
17Modulation of high-density lipoprotein cholesterol metabolism and reverse cholesterol transport. (16596814)Hersberger M.... von Eckardstein A.2005ABCA1
18Assessment of reaching goal in patients with combined hyperlipidemia: low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, or apolipoprotein B. (16291013)Stein E.A.... Laskarzewski P.2005APOB
19Abca7 null mice retain normal macrophage phosphatidyl choline and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. (15550377)Kim W.S.... Freeman M.W.2005APOA1
20Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossums. (15164335)Kushwaha R.S.... Vandeberg J.L.2004SOAT1
21Comparison of biosensors based on entrapment of cholesterol oxidase and cholesterol esterase in electropolymerized films of polypyrrole and diaminonaphthalene derivatives for amperometric determination of cholesterol. (12923606)Vidal J.C.... Castillo J.R.2003CEL
22Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol. (12975367)Temel R.E.... Rudel L.L.2003LCAT, SOAT2, SOAT1
23Effect of SMP-500, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on serum cholesterol level and LDL cholesterol clearance in hamsters with induced hyperlipidemia. (12207118)Ioriya K.... Ohashi N.2002CES1
24Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia. (11809427)Davidson M.... Hutchinson H.2002APOA1, APOB
25A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. (11790770)Sparrow C.P.... Menke J.G.2002NR1H3
26Rates of cholesterol esterification and esterified cholesterol net mass transfer between high-density lipoproteins and apolipoprotein B-containing lipoproteins in Type 1 diabetes. (12027932)Valabhji J.... Elkeles R.S.2002APOA1
27Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. (11732933)Lemieux I.... DesprAcs J.P.2001APOB
28Effects of probucol on cholesterol metabolism in mous e peritoneal macrophages: inhibition of HDL-mediated cholesterol efflux. (10998462)Takemura T.... Shichiri M.2000APOE, SOAT1
29Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae. (10833523)Uittenbogaard A.... Smart E.J.2000CAV1
30Amperometric determination of total cholesterol at gold electrodes covalently modified with cholesterol oxidase and cholesterol esterase with use of thionin as an electron mediator. (10079764)Nakaminami T.... Yoneyama H.1999CEL
31Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (10202851)Azuma Y.... Nobuhara Y.1999CES1
32Association of the A-204C polymorphism in the cholesterol 7alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. (10508208)Couture P.... Ordovas J.M.1999CYP7A1
33Potpourri: effects of unsaturation on lipid structure; plasma cholesterol ester and lipid-transfer proteins; and cholesterol-sensing proteins and cellular cholesterol movement. (9729730)Small D.M.1998CETP
34Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. (9555860)Westman J.... Diczfalusy U.1998CYP27A1
35Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. (9846584)Karvonen M.K.... Uusitupa M.I.1998NPY
36Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins. (9054384)Nishida H.I.... Nishida T.1997PLTP
37Cholesterol efflux, lecithin-cholesterol acyltransferase activity, and pre-beta particle formation by serum from human apolipoprotein A-I and apolipoprotein A-I/apolipoprotein A-II transgenic mice consistent with the latter being less effective for reverse cholesterol transport. (9047326)Castro G.... Rubin E.M.1997APOA2
38Apolipoprotein A-IFIN (Leu159-->Arg) mutation affects lecithin cholesterol acyltransferase activation and subclass distribution of HDL but not cholesterol efflux from fibroblasts. (9409289)Miettinen H.E.... Kontula K.1997APOA1, LCAT
3927-hydroxylated low density lipoprotein (LDL) cholesterol can be converted to 7alpha,27-dihydroxy-4-cholesten-3-one (cytosterone) before suppressing cholesterol production in normal human fibroblasts. Evidence that an altered metabolism of ldl cholesterol can underlie a defective feedback control in malignant cells. (8662693)Axelson M.... Larsson O.1996HMGCR
40Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. (8613070)Ito T.... Matsuzawa Y.1996CYP7A1
41Interleukin 1 stimulates cholesterol esterification and cholesterol deposition in J774 monocytes-macrophages. (8608158)MaziA"re C.... MaziA"re J.C.1996OSM, SOAT1
42Intrahepatic biliary cholesterol and phospholipid transport in humans: effect of obesity and cholesterol cholelithiasis. (8847482)Ahmed H.A.... Northfield T.C.1995HMGCR
43Pseudopregnancy-dependent accumulation of cholesterol sulfate due to up-regulation of cholesterol sulfotransferase and concurrent down-regulation of cholesterol sulfate sulfatase in the uterine endometria of rabbits. (7852287)Momoeda M.... Iwamori M.1994STS
44Effects of pravastatin and ursodeoxycholic acid on cholesterol and bile acid metabolism in patients with cholesterol gallstones. (8199696)Okamoto S.... Kuroki S.1994HMGCR, CYP7A1
45Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. (8033496)Hainer J.W.... Crouse J.R.1994CES1
46Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. (7929116)Kruth H.S.... Gamble W.1994APOE
47Non-cholesterol sterols, absorption and synthesis of cholesterol and apolipoprotein A-I kinetics in a Finnish lecithin-cholesterol acyltransferase deficient family. (1642689)Gylling H.... Miettinen T.A.1992APOA1, SOAT1
48Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin- cholesterol acyltransferase (Thr123-->Ile) and lecithin-cholesterol acyltransferase (Thr347-->Met). (1737840)Klein H.-G.... Brewer H.B. Jr.1992LCAT
49Dietary cholesterol, membrane cholesterol and cholesterol synthesis. (1782226)Lutton C.1991LMAN2
50Pancreatic cholesterol esterases. 3. Kinetic characterization of cholesterol ester resynthesis by the pancreatic cholesterol esterases. (2354156)Kyger E.M.... Lange L.G.1990CEL

Expression for genes affiliated with Cholesterol

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Cholesterol

Pathways for genes affiliated with Cholesterol

Sources:
36QIAGEN, 20KEGG, 10EMD Millipore, 41Thomson Reuters
See all sources

Pathways related to cholesterol according to GeneDecks:

(show top 50)    (show all 257)
idPathwayScoreTop Affiliating Genes
1Molecular Mechanisms of Cancer3619.7PIK3R2, PIK3R1, PIK3C2G, PIK3CG, LRP5, LRP6
2p38 Signaling3618.4KITLG, BMP2, BMP6, RAC1, UTS2, LIF
3Steroid hormone biosynthesis2018.3UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
4AMPK Enzyme Complex Pathway3617.2PIK3R2, PIK3R1, LIPE, LEP, CFTR, MLYCD
5Metabolism of xenobiotics by cytochrome P4502016.7UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
6PAK Pathway3616.0PIK3R2, PIK3R1, KITLG, BMP2, BMP6, RAC1
7Cytokine-cytokine receptor interaction2015.3KITLG, VEGFA, BMP2, LIF, LIFR, KDR
8Estrogen Pathway3615.3PIK3R2, PIK3R1, NCOA1, NCOA2, NCOA3, NCOR1
9Drug metabolism - other enzymes2015.2NAT2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5
10TGF-Beta Pathway3615.2PIK3R2, PIK3R1, KITLG, BMP2, BMP6, UTS2
11Development Leptin signaling via PI3K-dependent pathway1014.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PDE3B
12NF-KappaB Family Pathway3614.6PIK3R2, PIK3R1, REL, RELA, RELB, KITLG
13Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)4114.6SGMS1, LMAN2, SCP2, CETP, CES1, ARF1
14NFAT in Immune Response3614.3PIK3R2, PIK3R1, KITLG, BMP2, BMP6, UTS2
15Development_IGF-1 receptor signaling4114.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, REL
16Activation of PKC through GPCR3614.2PIK3R2, PIK3R1, PDE1A, PDE3B, KITLG, BMP2
17Development_Ligand-independent activation of ESR1 and ESR24114.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, NCOA1
18Regulation of lipid metabolism_Insulin signaling-generic cascades4114.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PDE3B
1914-3-3 Induced Intracellular Signaling3613.9PIK3R2, PIK3R1, KITLG, BMP2, RAF1, UTS2
20Immune response CD16 signaling in NK cells1013.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VAV1
21Development_Prolactin receptor signaling4113.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
22Regulation of lipid metabolism Insulin signaling-generic cascades1013.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PDE3B
23Jak-STAT signaling pathway2013.6PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIAS1
24Transcription_CREB pathway4113.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
25Development Endothelin-1/EDNRA transactivation of EGFR1013.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
26Development Flt3 signaling1013.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VAV1
27Transcription_Receptor-mediated HIF regulation4113.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VEGFA
28Development VEGF signaling and activation1013.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, REL
29T cell receptor signaling pathway2013.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
30Natural killer cell mediated cytotoxicity2013.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
31Development Endothelin-1/EDNRA signaling1013.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
32Transcription Androgen Receptor nuclear signaling1013.0NCOA1, NCOA2, NCOR1, RAF1, SCAP, MMP2
33Development Glucocorticoid receptor signaling1012.9NCOA1, NCOA2, REL, RELA, RELB, SERPINE1
34Development_CNTF receptor signaling4112.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
35NGF Pathway3612.7PIK3R2, PIK3R1, MYC, RAF1, RAC1, BAX
36Prostate cancer2012.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
37Development_ERBB-family signaling4112.6PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, REL
38Development_VEGF signaling and activation4112.6PIK3CB, PIK3CA, PIK3R2, REL, RELA, RELB
39Transcription Role of VDR in regulation of genes involved in osteoporosis1012.6VDR, BGLAP, CGA, JUN, CDKN1C, FOS
40Transcription_Role of VDR in regulation of genes involved in osteoporosis4112.5VDR, BGLAP, CGA, JUN, CDKN1C, FOS
41Pertussis2012.4RELA, SERPING1, JUN, CD14, ITGA5, ITGAM
42TRKA Signaling3612.4PIK3R2, PIK3R1, MYC, RAF1, RAC1, BAX
43Development ERBB-family signaling1012.3PIK3CB, PIK3CD, PIK3R2, PIK3R1, REL, RELA
44Development Leptin signaling via JAK/STAT and MAPK cascades1012.2LEP, LEPR, JAK2, GRB2, MAPK3, MAP2K1
45Development VEGF signaling via VEGFR2 - generic cascades1012.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
46Glioblastoma Multiforme3612.1PIK3R2, PIK3R1, RB1, RAF1, RAC1, CDK2
47Development HGF signaling pathway1012.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
48Leishmaniasis2012.0NCF2, RELA, JUN, JAK2, ITGA4, ITGAM
49Glioma2012.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
50Pancreatic cancer2011.2PIK3R2, AKT2

Compounds for genes affiliated with Cholesterol

Sources:
32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
See all sources

Compounds related to cholesterol according to GeneDecks:

(show top 50)    (show all 574)
idCompoundScoreTop Affiliating Genes
1atp32 53.2ZNF202, PIK3CB, PIK3CA, PIK3R1, PIK3C2A, LRAT
2vegf32 38.5PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
3h2o232 33.5PIK3CB, PIK3R1, PIK3CG, NCF2, SGK1, KITLG
4cyclosporin a32 42 31.3PIK3CA, PIK3C2A, PIK3CG, COG2, RECK, REL
5cisplatin32 34 9 9 28.5PIK3CA, PIK3C2A, CNR2, KITLG, VTN, RB1
6gtp32 24.7PIK3CA, PIK3R1, PIK3C2A, NCF2, PDE3B, RECK
7acth32 23.8PIK3C2A, PDE3B, REN, SERPINA7, SERPINA6, SERPINA1
8acyl-coa32 22.0LRAT, PCK2, LPL, LIPE, SCD, SCP2
9doxorubicin32 34 9 9 24.5PIK3CA, PIK3C2A, PIK3CG, RECK, KITLG, SELE
10ascorbic acid32 18 21.9PIK3CG, SFTPB, RBP4, VDR, BMP2, RAF1
11endotoxin32 20.2RECK, RETN, SFTPD, PCK2, GC, SELL
12carbon32 20.1CNR1, CNR2, VWF, VTN, SFTPD, LPL
13tacrolimus32 34 9 9 22.8PIK3CA, REL, REN, VTN, SERPINE1, NAGLU
14choline32 9 18 9 22.8PIK3C2A, VIM, VIP, MYB, RAF1, RAPSN
15urea32 9 18 9 22.0PIK3C2A, RETN, VTN, PCK2, GC, SERPINA7
16isoproterenol32 9 9 20.9PIK3R2, PIK3R1, PDE3B, SELL, VIM, LPAR3
17rifampicin32 18.8NCOA1, SERPINA7, NAT2, UGT1A1, UGT1A6, FASLG
18valproic acid32 34 9 18 9 22.4COG2, RELN, KITLG, BDNF, UGT1A1, UGT1A10
19histidine32 18.3PDE3B, KITLG, SERPINA7, RARA, LIPF, KCNH2
20haloperidol32 34 9 9 20.6PIK3C2A, REN, VIP, BDNF, KCNH2, SCD
21ketoconazole32 42 9 18 9 21.5SERPINA6, UGT1A1, AR, GSR, IL1A, CCND3
22mifepristone32 42 9 9 20.3NCOA1, NCOA2, NCOR1, NCOR2, SGK1, SERPINA6
23phosphatidylserine32 9 9 18.9RECK, VWF, SELE, SELPLG, VIM, LPL
24etoposide32 42 9 9 19.6PIK3CB, PIK3CA, PIK3R1, PIK3CG, RECK, RB1
25diclofenac32 34 9 9 19.6SELL, SERPINC1, SERPINA7, NAGLU, CHKB, UGT1A1
26phenylalanine32 16.4PIK3R1, SFTPC, SELPLG, SERPINA7, VAV1, RAB6A
27vitamin b1232 16.4LRP2, VWF, SERPINA3, LPA, MUT, MTHFR
28galactose32 16.2RECK, GC, SELL, CLEC4A, LGALS4, LEPR
29curcumin32 16.2PIK3CG, VTN, VEGFA, VCAM1, MYC, RAF1
30betacarotene32 16.0LRAT, VWF, RB1, RBP4, RBP2, SERPINA3
31thromboxane a232 18 17.0PIK3C2A, VWF, SELP, NAGLU, LIF, BDKRB1
32adenine32 9 18 9 18.6PDE3B, VWF, NAT2, MYB, LEP, UGT1A1
33phosphoenolpyruvate32 9 9 17.5PCK2, PCK1, GCK, BLZF1, CEBPB, FOXM1
34opiate32 15.2CHRM2, CGA, GUSB, ARRB2, APP, MC4R
35paraxanthine32 18 16.1NAT2, XDH, CYP4Z1, CYP1A1, CYP1A2, CYP1B1
36inositol32 15.0PIK3CB, PIK3CD, LPL, BDNF, BCR, CHGA
37amlodipine32 9 18 9 17.5REN, SERPINE1, VCAM1, ALB, CACNA1B, HMGCR
38ang ii32 13.8PIK3CG, REN, VEGFA, JAK2, CD36, IL6ST
3925-hydroxyvitamin d32 13.8GC, SEC14L2, VDR, BGLAP, PAX5, SCG5
40menadione32 9 18 9 16.7VKORC1, BGLAP, MTHFR, XDH, CDK2, CDC25C
41calyculin a32 42 9 9 16.6RB1, VIM, BCAR1, CFTR, CDK2, CDKN3
42ag 147832 13.6PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, JUN
43celecoxib32 42 34 9 18 9 18.2PIK3R1, PIK3CG, REN, VEGFA, BIRC5, PARP1
44cardiolipin32 9 9 15.1VDAC1, CFH, MPZ, CD79A, CD40LG, FDX1
45pertussis32 13.0PIK3CG, VIP, LPAR1, CHRM2, JUN, ITGA4
46irinotecan32 34 9 9 16.0VEGFA, PARP1, UGT1A1, UGT1A6, UGT1A7, UGT1A9
47ganciclovir32 9 9 14.5KITLG, VIM, BMP6, KDR, LEP, CEACAM3
48leflunomide32 9 9 14.5LCK, SAA4, FYN, MMP1, MMP3, IL13
49gefitinib32 34 9 9 15.0PIK3CA, PIK3CG, SFTPD, SELP, VIM, VEGFA
50glucose32 10.0CANX, CYP20A1, PKM

GO Terms for genes affiliated with Cholesterol

Sources:
12Gene Ontology
See all sources

Cellular components related to cholesterol according to GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588667.5PIK3CD, PIK3R1, PIK3C2B, PIK3C2A, PIK3CG, LRP4
2cytoplasmGO:00573752.4ZNF259, PIK3C2A, PIK3CG, LRP1, RFWD3, NCF2
3cytosolGO:00582951.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
4extracellular regionGO:00557642.3LRP8, LRPAP1, KL, REG1A, RETN, KITLG
5endoplasmic reticulum membraneGO:00578939.8LRAT, SGK1, RDH11, VKORC1, LMAN2, LMF1
6integral to plasma membraneGO:00588737.2LRP1, LRP12, KL, NCSTN, SGMS2, CNR1
7extracellular spaceGO:00561533.9LRP2, KL, RELN, REN, CNP, KITLG
8mitochondrionGO:00573930.4SGK1, PCK2, PCCB, GCK, GCSH, SERAC1
9endoplasmic reticulumGO:00578328.7PIK3C2B, LRP2, LRP5, LRP6, LRPAP1, NCEH1
10membraneGO:01602025.3PIK3C2G, PIK3CG, PDE3B, RECK, REN, SELPLG
11Golgi apparatusGO:00579425.2PIK3C2A, LRP2, KLF5, NCOA2, NCOA3, NCSTN
12nucleoplasmGO:00565425.0PIAS1, NCOA1, NCOA2, NCOA3, NCOA6, NCOR1
13intracellular membrane-bounded organelleGO:04323121.7PIK3C2B, KLF5, NCOA6, LPAR3, VCP, RAB7A
14cell surfaceGO:00998620.3LRP6, LRPAP1, PCSK9, VLDLR, VEGFA, LPAR1
15apical plasma membraneGO:01632418.2LRP2, KCNMA1, SCNN1A, MUC17, CFTR, ATP8B1
16membrane raftGO:04512117.4RFTN1, SELE, BSG, RAB5A, CLN3, PAG1
17lysosomeGO:00576417.0LRP2, SFTPB, SFTPD, PCSK9, VPS4B, NAGLU
18external side of plasma membraneGO:00989715.8VWF, SELL, SELP, VCAM1, KDR, BCAM
19endosomeGO:00576815.7LRP2, VPS4B, RAB11FIP2, RAPGEF1, CLIP1, ZFYVE20
20caveolaGO:00590114.5LRP6, LRP8, SELE, LIPE, CLN3, KCNA5
21high-density lipoprotein particleGO:03436414.4LIPC, LCAT, SAA1, SAA4, CETP, APOA1

Biological processes related to cholesterol according to GeneDecks:

(show top 50)    (show all 62)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428165.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
2signal transductionGO:00716528.1ZNF259, PIK3CB, PIK3CD, LRP12, LRP8, PDE1A
3blood coagulationGO:00759625.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP8
4lipid metabolic processGO:00662924.6ZNF202, LRP10, LRP2, LRP8, LPA, LPL
5response to drugGO:04249323.9LRP2, NCF2, REN, SERPINA7, VLDLR, LPL
6cellular lipid metabolic processGO:04425523.2NCOA1, NCOA2, NCOA3, NCOA6, NCOR1, NCOR2
7positive regulation of cell proliferationGO:00828421.4LRP5, KLB, KLF5, REG1A, CNBP, VIP
8apoptotic processGO:00691521.1KLF11, NCSTN, PDCD6IP, SGK1, SGMS1, PCSK9
9positive regulation of transcription, DNA-dependentGO:04589320.9PIAS1, LRP5, LRP6, KLF5, NCOA1, NCOA3
10cholesterol homeostasisGO:04263220.6LRP5, PCSK9, MYLIP, LIPG, LIPC, SCARB1
11negative regulation of transcription from RNA polymerase II promoterGO:00012220.0ZNF202, LRP8, KLF11, NCOA2, NCOR1, NCOR2
12platelet activationGO:03016819.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF
13phospholipid metabolic processGO:00664419.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
14steroid metabolic processGO:00820219.8LRAT, LRP2, RDH11, GC, RBP2, CLPS
15inflammatory responseGO:00695419.3PIK3CD, PIK3CG, RELA, CNR2, SELE, SELP
16synaptic transmissionGO:00726819.1CNP, LPAR3, VAMP2, RAB3A, RAF1, RAPSN
17response to hypoxiaGO:00166618.6SFTPB, SERPINA1, VEGFA, VCAM1, BMP2, RAF1
18transcription initiation from RNA polymerase II promoterGO:00636718.5NCOA6, NCOR1, NCOR2, SERPINE1, VDR, MYC
19insulin receptor signaling pathwayGO:00828618.3PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PIK3C3
20virus-host interactionGO:01904817.5PIK3R1, PDCD6IP, RELA, RB1, VIM, VDAC1
21lipid transportGO:00686917.4LRP10, PCTP, VLDLR, LPA, CLN8, SCP2
22cholesterol biosynthetic processGO:00669517.3CNBP, SC5DL, MVD, MVK, LBR, MSMO1
23innate immune responseGO:04508717.3PIK3CD, PIK3CG, PIK3C3, NCF2, RELA, SFTPD
24negative regulation of cell proliferationGO:00828517.0KLF11, NDN, VDR, BMP2, RARG, RARB
25lipoprotein metabolic processGO:04215716.8PCSK9, LPA, LPL, SCARB1, LDLR, LCAT
26cell-cell signalingGO:00726716.8PCSK5, NAMPT, LNPEP, BMP2, S100A9, CGA
27positive regulation of apoptotic processGO:04306516.6LRP6, KLF11, NCOA1, CNR1, LPAR1, BMP2
28negative regulation of apoptotic processGO:04306616.5PIK3CG, RELA, SERPINE1, VEGFA, MYC, RAF1
29response to lipopolysaccharideGO:03249616.3NCF2, CNR1, CNR2, SFTPB, SFTPC, SELE
30bile acid metabolic processGO:00820616.2SCP2, LEP, CH25H, BAAT, ATP8B1, ARV1
31response to glucocorticoid stimulusGO:05138415.8SFTPB, SFTPC, PCK2, SERPINE1, BGLAP, BCHE
32agingGO:00756815.8LRP2, KL, NCF2, CNR1, SERPINA7, VDR
33anti-apoptosisGO:00691615.7PIK3CA, RELA, VNN1, BIRC5, BECN1, BDNF
34response to nutrientGO:00758415.3CNR1, SERPINC1, VLDLR, VCAM1, LIPG, CHAT
35epidermal growth factor receptor signaling pathwayGO:00717315.1PIK3CA, PIK3R1, PIK3C2A, PDE1A, RAF1, CLTC
36triglyceride metabolic processGO:00664115.0PCSK9, LPL, LIPF, CEL, CETP, INSIG1
37cholesterol effluxGO:03334414.9SCARB1, APOA1, APOA2, APOA4, APOC1, APOC2
38heart developmentGO:00750714.9NCOA6, PCSK5, RBP4, VLDLR, VCAM1, BMP2
39receptor-mediated endocytosisGO:00689814.8LRP1B, LRP2, SFTPD, VLDLR, LPA, CLTC
40platelet degranulationGO:00257614.8VWF, SELP, SERPINF2, SERPINA1, SERPINE1, SERPING1
41response to insulin stimulusGO:03286814.7PCK1, RBP4, SCAP, LEP, UCP3, IRS1
42response to glucose stimulusGO:00974914.6NCF2, SFTPB, SFTPC, GYS2, IRS2, INSR
43leukocyte migrationGO:05090014.6PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELL, SELP
44positive regulation of cell migrationGO:03033514.6VEGFA, BMP2, KDR, BCAR1, CGA, FURIN
45glucose homeostasisGO:04259314.6PDE3B, PCK1, GCK, RBP4, SERPINE1, USF1
46regulation of blood pressureGO:00821714.4LRP5, REN, SGK1, UTS2, LEP, CHGA
47response to organic cyclic compoundGO:01407014.4NCF2, SELP, SERPINA1, UGT1A1, JUN, CDK1
48response to estradiol stimulusGO:03235514.2NCOA1, GC, SERPINA1, VDR, RARA, MMP9
49response to ethanolGO:04547114.2CNR1, RBP4, BGLAP, CHAT, S100A8, S100A9
50positive regulation of peptidyl-tyrosine phosphorylationGO:05073112.4LRP8, RELN, KITLG, VTN, VEGFA, LIF

Molecular functions related to cholesterol according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552429.9PIK3CB, PIK3CD, PIK3CA, PIK3C2B, PIK3C2G, PIK3C2A
2protein homodimerization activityGO:04280326.8LRP4, LRP6, NCOA6, VWF, SFTPC, SERPINF2
3iron ion bindingGO:00550624.8SC5DL, SCD5, SCD, CH25H, XDH, MSMO1
4heme bindingGO:02003723.9SDHC, MPO, JAK2, FECH, FADS1, FADS2
5electron carrier activityGO:00905523.8NCF2, SDHB, SDHC, P4HB, XDH, GSR
6receptor bindingGO:00510220.4LRP6, REN, CNTNAP4, SELPLG, SERPINE1, LPL
7enzyme bindingGO:01989920.0PIAS1, NCOA1, NCOA6, GCSH, VAPB, RARA
8lipid bindingGO:00828918.2LPAR3, VCP, BPI, LIPF, BAX, LBP
9protein heterodimerization activityGO:04698217.1VEGFA, VAPA, VAPB, MYC, BMP2, BMP6
10monooxygenase activityGO:00449715.7BCMO1, PTGIS, TBXAS1, CYP4F11, CYP1A2, CYP1B1
11drug bindingGO:00814415.4PDE3B, CNR1, CHKA, CHRM2, CHRM1, CHRM3
12cholesterol bindingGO:01548515.4CETP, APOA1, APOA2, APOC3, APOD, APOF
13steroid hormone receptor activityGO:00370714.9VDR, RARG, RARA, RARB, GPER, HNF4A
14aromatase activityGO:07033014.7CYP4Z1, CYP4F8, CYP4F11, CYP1A1, CYP1A2, CYP1B1
15transcription regulatory region DNA bindingGO:04421214.6KLF11, NCOR1, RELA, CIITA, YY1, BASP1
16ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487914.4AR, HNF4A, ESR2, ESRRA, ESRRB, PPARG
17retinoic acid bindingGO:00197213.1LRAT, RARA, UGT1A1, UGT1A10, UGT1A3, UGT1A4
18protein bindingGO:005515INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B

Sources for Cholesterol

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS