MCID: CHN004
MIFTS: 40

Chondroblastoma malady

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

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Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 11 48 50 39 13 68
 
Chondroblastoma of Bone 11

Classifications:



External Ids:

Disease Ontology11 DOID:2649
MeSH39 D002804
NCIt45 C2945

Summaries for Chondroblastoma

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Wikipedia:71 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to blastoma and aneurysm, and has symptoms including pain An important gene associated with Chondroblastoma is SOX9 (SRY-Box 9), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Osteoblast Signaling. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Related Diseases for Chondroblastoma

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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1blastoma10.8
2aneurysm10.3
3aneurysmal bone cysts10.3
4binocular vision disease10.3PTH1R, TNFSF11
5hepatic fibrosis renal cysts mental retardation10.2PTGS2, TNFSF11
6nasal cavity inverting papilloma10.2CXCL8, TNFSF11
7common peroneal nerve lesion10.1CXCL8, IL5
8primary non-gestational choriocarcinoma of ovary10.1CXCL8, PTGS2
9middle lobe syndrome10.1CXCL8, IL5
10fibroma10.1
11chondromyxoid fibroma10.1
12infectious anterior uveitis10.1CXCL8, IL5
13thanatophoric dysplasia, type i10.1FGFR1, PTH1R, SOX9
14t cell immunodeficiency primary10.0FGFR1, SOX9
15chondrosarcoma10.0
16conidiobolomycosis10.0CXCL8, IL4
17psychotic disorder10.0CXCL8, IL4
18retinal vascular disease10.0CXCL8, IL4
19marasmus10.0IL4, IL5
20papillary squamous carcinoma10.0IL4, IL5
21lens-induced iridocyclitis10.0IL4, IL5
22spastic paraplegia 3a, autosomal dominant10.0IL4, IL5
23thelaziasis10.0IL4, IL5
24chancroid10.0CXCL8, IL4
25hypersensitivity vasculitis10.0IL4, IL5
26lymphoblastic leukemia10.0IL4, IL5
27multiple epiphyseal dysplasia due to collagen 9 anomaly10.0IL4, IL5
28urethral intrinsic sphincter deficiency10.0IL4, IL5
29bone peripheral neuroepithelioma10.0IL4, IL5
30indian plum allergy10.0IL4, IL5
31luminal breast carcinoma10.0IL4, IL5
32lactose intolerance10.0IL4, IL5
33conjunctival concretion10.0CXCL8, IL5, PTGS2
34acute gonococcal prostatitis9.9IL4, IL5
35cerebral primitive neuroectodermal tumor9.9IL4, IL5
36hidradenitis9.9CXCL8, PTGS2
37askin's tumor9.9IL4, IL5
38apricot allergy9.9IL4, IL5
39trachea leiomyoma9.9IL4, IL5
40visceral steatosis9.9IL4, IL5
41birth defects9.9CXCL8, FGFR1, IL5
42cutaneous fibrous histiocytoma9.9IL4, IL5
43giant cell tumor9.9
44clear cell chondrosarcoma9.9
45osteonecrosis9.9CXCL8, PTGS2, SOX9, TNFSF11
46autosomal recessive type iv ehlers-danlos syndrome9.9CXCL8, IL4, TNFSF11
47histoplasmosis retinitis9.9IL4, IL5
48allescheriosis9.9CA10, IL4, IL5
49lymphocytic gastritis9.9IL4, IL5
50chondroma9.8

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

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UMLS symptoms related to Chondroblastoma:


pain

MGI Mouse Phenotypes related to Chondroblastoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9FGFR1, IL4, PTH1R, SOX9, TNFSF11
2MP:00030128.6FGFR1, IL4, PTGS2, SOX9, TNFSF11
3MP:00053808.6FGFR1, HK2, IL5, PTGS2, PTH1R, SOX9
4MP:00053888.4IL4, IL5, PTGS2, PTH1R, SOX9, TNFSF11
5MP:00028738.2FGFR1, HK2, IL4, PTGS2, SOX9, TNFSF11
6MP:00053818.2FGFR1, IL4, IL5, PTGS2, PTH1R, SOX9
7MP:00053898.1FGFR1, IL4, IL5, PTGS2, SOX9, TNFSF11
8MP:00053907.5FGFR1, IL4, PTGS2, PTH1R, SOX9, TNFSF11
9MP:00053787.4FGFR1, HK2, IL4, IL5, PTGS2, PTH1R

Drugs & Therapeutics for Chondroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chondroblastoma


Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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MalaCards organs/tissues related to Chondroblastoma:

36
Bone, Lung, Testes, Thyroid, Cortex

Publications for Chondroblastoma

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Articles related to Chondroblastoma:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. (27798068)
2016
2
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. (27504302)
2016
3
Malignant chondroblastoma of extraskeletal origin. (27127749)
2016
4
Epigenetics: Histone mutations reprogramme chondroblastoma. (27339705)
2016
5
Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls. (27011442)
2016
6
What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? A Report on Functional Results, Arthritis, and Arthroplasty. (26831477)
2016
7
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. (27966029)
2016
8
Temporal bone chondroblastoma totally invisible on MRI. (26743837)
2016
9
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use. (26726978)
2016
10
Reconstruction with double pedicel fibular graft and ankle arthrodesis for aggressive chondroblastoma in the distal tibia. (27176605)
2016
11
A rare case of chondroblastoma of the acromion. (27956080)
2016
12
Chondroblastoma of sella and anterior cranial fossa base. (26394622)
2016
13
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. (27299121)
2016
14
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. (27067177)
2016
15
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. (26844533)
2016
16
Operative treatment of chondroblastoma: a study of 11 cases. (26984656)
2016
17
Benign chondroblastoma on fine-needle aspiration smears: A seven-case experience and review of the literature. (25914148)
2015
18
Atypical giant chondroblastoma mimicking a chondrosarcoma. (26458670)
2015
19
Chondroblastoma-like osteosarcoma: a case report and review. (25492634)
2015
20
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. (27408892)
2015
21
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. (26457357)
2015
22
Calcaneal chondroblastoma with pathologic fracture and recurrence. (25624038)
2015
23
Chondroblastoma of the Clivus: Case Report and Review. (26623238)
2015
24
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. (25647721)
2015
25
Temporal Bone Localized Chondroblastoma. (26517458)
2015
26
Arthroscopic burring of exposed cement following curettage and cavity filling cementation for chondroblastoma of the proximal tibia. (25750896)
2015
27
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. (26714409)
2015
28
Chondroblastoma of the scaphoid: A case report. (26458718)
2015
29
Chondroblastoma of bone in the extremities: a multicenter retrospective study. (26041854)
2015
30
Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. (25432292)
2015
31
Surface-based chondroblastoma of the tibia: a unique presentation. (25851832)
2015
32
Chondroblastoma-like chondroma of the hand: case report. (24656394)
2014
33
Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist. (24876212)
2014
34
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
35
Chondroblastoma of the knee treated with resection and osteochondral allograft reconstruction. (25548701)
2014
36
Chondroblastoma: a clinico-pathological analysis. (25523724)
2014
37
Chondroblastoma of the distal phalanx. (24810830)
2014
38
Chondroblastoma of the navicular bone. (25780542)
2014
39
Chondroblastoma of the patella with aneurysmal bone cyst. (24683664)
2014
40
Chondroblastoma of the medial cuneiform bone in a 32-year-old woman. (25072961)
2014
41
What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? (25115583)
2014
42
CORR InsightsAr: what are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? (25163690)
2014
43
Fine needle aspiration cytology of chondroblastoma of the fibula. (25745297)
2014
44
Chondroblastoma-like osteosarcoma. (25143130)
2014
45
Minimally invasive technique for curettage of chondroblastoma using endoscopic technique. (25491613)
2014
46
Chondroblastoma with secondary aneurysmal bone cyst of the capitate. (24810829)
2014
47
Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. (24639947)
2014
48
Chondroblastoma and chondromyxoid fibroma. (23545728)
2013
49
A guise of osteosarcoma: Chondroblastoma-like. (24355968)
2013
50
Chondroblastoma of the temporal bone. (23851845)
2013

Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.8PTH1R, TNFSF11
29.8PTH1R, TNFSF11
39.5CXCL8, PTGS2
49.2FGFR1, PTH1R, SOX9
59.1IL4, IL5
69.1IL4, IL5
79.1IL4, IL5
89.1IL4, IL5
99.1IL4, IL5
109.1CXCL8, PTGS2, TNFSF11
118.7CXCL8, IL4, PTGS2
128.7CXCL8, IL4, PTGS2
138.7CXCL8, IL4, IL5
148.7CXCL8, IL4, IL5
15
Show member pathways
8.7CXCL8, IL4, IL5
168.4CXCL8, IL4, PTGS2, SOX9
178.3CXCL8, IL4, IL5, TNFSF11
18
Show member pathways
8.2CXCL8, IL4, IL5, PTGS2
19
Show member pathways
8.2CXCL8, IL4, IL5, PTGS2
20
Show member pathways
7.7CXCL8, FGFR1, IL4, IL5, TNFSF11
21
Show member pathways
7.7CXCL8, FGFR1, IL4, IL5, TNFSF11
22
Show member pathways
7.2CXCL8, FGFR1, IL4, IL5, PTGS2, TNFSF11
23
Show member pathways
7.2CXCL8, FGFR1, IL4, IL5, PTGS2, TNFSF11
24
Show member pathways
6.9CXCL8, FGFR1, IL4, IL5, PTGS2, SOX9

GO Terms for genes affiliated with Chondroblastoma

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Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.5SOX9, TNFSF11
2bone resorptionGO:004545310.5PTH1R, TNFSF11
3bone mineralizationGO:003028210.4PTGS2, PTH1R
4cell maturationGO:004846910.3FGFR1, PTH1R
5positive regulation of mesenchymal cell proliferationGO:000205310.2FGFR1, SOX9
6regulation of cell differentiationGO:004559510.2FGFR1, SOX9
7ossificationGO:000150310.2PTH1R, SOX9, TNFSF11
8chondrocyte differentiationGO:000206210.0FGFR1, PTH1R, SOX9
9positive regulation of B cell proliferationGO:00308909.8IL4, IL5
10angiogenesisGO:00015259.6CXCL8, FGFR1, PTGS2
11regulation of cell proliferationGO:00421279.6FGFR1, PTGS2, SOX9
12negative regulation of cell proliferationGO:00082859.6CXCL8, PTGS2, PTH1R, SOX9
13positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL4, IL5, TNFSF11
14skeletal system developmentGO:00015019.2FGFR1, PTH1R, SOX9
15immune responseGO:00069559.0CXCL8, IL4, IL5, TNFSF11
16positive regulation of cell proliferationGO:00082848.0FGFR1, IL4, IL5, PTGS2, PTH1R, SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3CXCL8, IL4, IL5, TNFSF11

Sources for Chondroblastoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet