Chondroblastoma malady

Wikipedia: Chondroblastoma is a rare bone tumor, usually benign with a slow-growing nature.⁴⁴ more...

MalaCards: Chondroblastoma, also known as chondroblastoma nos (morphologic abnormality), is related to clear cell chondrosarcoma and chondrosarcoma. An important gene associated with Chondroblastoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and wtCFTR and deltaF508 traffic / Membrane expression (norm and CF). The compounds b 723 and pge2 have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are reproductive system and immune system.

Aliases & Descriptions:

chondroblastoma 6 30 8 32 43 chondroblastoma nos (morphologic abnormality) 6

chondroblastoma (morphologic abnormality) 6 chondroblastoma of bone 6

Diseases related to chondroblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 312)

id	Related Disease	Score	Top Affiliating Genes
1	clear cell chondrosarcoma	28.5	VIM, PTHLH
2	chondrosarcoma	25.1	SERPINA3, VIM, S100A1, IL8, TNFSF11, PTGS2
3	dysgerminoma	13.4	PTHLH, KRT7, SOX9
4	adenosquamous carcinoma	13.4	PTHLH, KRT8, KRT7
5	sweat gland carcinoma	13.3	S100A1, KRT8, KRT7
6	bone cancer	13.3	USP6, TNFSF11, PTHLH
7	myofibroma	13.2	VIM, CALD1
8	epithelioid leiomyosarcoma	13.2	SERPINA3, VIM, PTHLH
9	endometrial stromal nodule	13.2	VIM, CALD1
10	chondroid chordoma	13.2	VIM, S100A1
11	mammary paget's disease	13.2	TNFSF11, KRT8, KRT7
12	ovarian sex cord tumors	13.2	VIM, PTHLH, KRT7
13	papillary adenoma	13.2	VIM, KRT7
14	papillary cystic tumor	13.2	SERPINA3, VIM
15	brooke-spiegler syndrome	13.1	VIM, KRT8, KRT7
16	sertoli cell tumor	13.1	VIM, KRT7, SOX9
17	malignant mixed mullerian tumor	13.1	VIM, S100A1, KRT7
18	parachordoma	13.1	VIM, KRT8, KRT7
19	egg allergy	13.1	IL4, IL5
20	epithelioid sarcoma	13.1	VIM, KRT8, KRT7
21	serous cystadenoma	13.1	VIM, S100A1, KRT7
22	spindle cell sarcoma	13.1	VIM, KRT8, KRT7
23	trichoepithelioma	13.1	VIM, KRT8, KRT7
24	giant axonal neuropathy	13.1	VIM, TUBB
25	glomus tumor	13.1	VIM, S100A1, CALD1
26	polymorphous low-grade adenocarcinoma	13.1	VIM, CHKB, S100A1
27	perivascular epithelioid cell tumor	13.1	VIM, S100A1, CALD1
28	anaplastic carcinoma	13.1	VIM, KRT8, KRT7
29	cellular schwannoma	13.0	VIM, S100A1
30	granular cell tumor	13.0	SERPINA3, VIM, S100A1
31	synovial sarcoma	13.0	VIM, KRT8, KRT7
32	cough variant asthma	13.0	IL4, IL5
33	hemangioblastoma	13.0	VIM, S100A1, KRT8
34	adenoameloblastoma	13.0	SERPINA3, TNFSF11, KRT8, KRT7
35	barrett's adenocarcinoma	13.0	S100A2, PTGS2, KRT7
36	hemangiopericytoma	13.0	VIM, S100A1, CALD1
37	rectum sarcomatoid carcinoma	12.9	VIM, S100A1, KRT8, KRT7
38	oxyphilic adenoma	12.9	VIM, S100A1, KRT8, KRT7
39	renal oncocytoma	12.9	VIM, S100A1, KRT8, KRT7
40	chromophobe renal cell carcinoma	12.9	VIM, S100A1, KRT8, KRT7
41	giant cell tumor	12.9	SERPINA3, VIM, TNFSF11
42	neurilemmoma	12.9	VIM, S100A1, KRT8
43	cholesteatoma	12.9	CHKB, S100A1, S100A2, TNFSF11, PTHLH
44	allergic bronchopulmonary aspergillosis	12.9	IL4, IL5
45	paraneoplastic syndromes	12.8	IL2, IL5, PTHLH
46	inflammatory myofibroblastic tumor	12.8	VIM, S100A1, PTGS2
47	osteoporosis, postmenopausal	12.8	IL2, TNFSF11, PTHLH
48	uterine carcinosarcoma	12.8	VIM, S100A1, PTGS2
49	small cell carcinoma	12.8	VIM, PTHLH, KRT8, KRT7
50	allergic conjunctivitis	12.8	IL4, IL5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to chondroblastoma:

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MGI Mouse Phenotypes related to chondroblastoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	8.0	IL4, ADAMTS5, SOX9, KRT8, PTGS2, TNFSF11
2	immune system phenotype	MP:0005387	6.2	SOX9, KRT8, PTHLH, PTGS2, TNFSF11, IL8

Articles related to chondroblastoma:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	Immunohistochemical analysis for Sox9 reveals the car tilaginous character of chondroblastoma and chondromyxoid fibroma of the bone. (19801163)	Konishi E.... Yanagisawa A.	2010	SOX9
2	A balanced t(5;17) (p15;q22-23) in chondroblastoma: f requency of the re-arrangement and analysis of the candidate genes. (19903358)	Romeo S.... Hogendoorn P.C.	2009	CA10
3	Cytokine synthesis by chondroblastoma: relation to lo cal inflammation. (19398795)	Uchikawa C.... Takagishi K.	2009	IL2, IL8, IL4
4	False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)	Hamada K.... Hatazawa J.	2006	HK2
5	Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma. (16484006)	SAPder S.... Aigner T.	2006	VIM
6	Temporal bone chondroblastoma: a review. (15875910)	Bian L.G.... Bertalanffy H.	2005	S100A1
7	Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. (13680221)	Shinmura K.... Imakiire A.	2004	PTGS2
8	Receptor activator of NF-kappaB ligand (RANKL) is expressed in chondroblastoma: possible involvement in osteoclastic giant cell recruitment. (12665629)	Huang L.... Kumta S.M.	2003	TNFSF11
9	Metastatic chondroblastoma with elevated creatine kinase and paraneoplastic neurologic autoimmunity. (14608202)	Joshi D.D.... Lennon V.A.	2003	CHKB
10	Expression of collagen type II, S100B, S100A2 and osteocalcin in chondroblastoma and chondromyxoid fibroma. (12168078)	Park H.R.... Unni K.K.	2002	S100A2
11	Electron microscopic and immunohistochemical studies on chondroblastoma (1512479)	Morimoto K.... Okada S.	1992	SERPINA3
12	Cytokeratin expression in chondroblastomas. (1692005)	Semmelink H.J.... Ramaekers F.C.	1990	KRT8, KRT7

Genes related to chondroblastoma according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	PTHLH	parathyroid hormone-like hormone	11.0
2	RCN3	reticulocalbin 3, EF-hand calcium binding domain	11.0
3	S100A2	S100 calcium binding protein A2	11.0	Publications
4	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	11.0	Expressions
5	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
6	TUBB2A	tubulin, beta 2A class IIa	11.0
7	USP6	ubiquitin specific peptidase 6 (Tre-2 oncogene)	11.0
8	ZNF133	zinc finger protein 133	11.0	Disorders
9	TUBA1C	tubulin, alpha 1c	11.0
10	S100A1	S100 calcium binding protein A1	11.0	Publications
11	HK2	hexokinase 2	11.0	Publications
12	ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	11.0
13	KRT8	keratin 8	11.0	Publications
14	KRT7	keratin 7	11.0	Publications
15	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
16	CHKB	choline kinase beta	11.0	Publications
17	CALD1	caldesmon 1	11.0
18	ADCY1	adenylate cyclase 1 (brain)	11.0
19	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
20	VIM	vimentin	11.0	Publications
21	CA10	carbonic anhydrase X	11.0	Publications
22	TUBB	tubulin, beta class I	11.0
23	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
24	IL4	interleukin 4	11.0	Publications
25	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
26	IL8	interleukin 8	11.0	Publications
27	IL2	interleukin 2	11.0	Publications

Pathways related to chondroblastoma according to GeneDecks:

(show all 39)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.3	IL2
2	wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)41	9.8	TUBA1C, TUBB, TUBB2A
3	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.8	TNFSF11, PTHLH, ADCY1
4	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.8	ADCY1, PTHLH, TNFSF11
5	Cell adhesion Gap junctions10	9.8	TUBB2A, TUBB, TUBA1C
6	Gap junction20	9.8	ADCY1, TUBB2A, TUBB, TUBA1C
7	Cytoskeleton remodeling Neurofilaments10	9.7	VIM, TUBA1C, TUBB, TUBB2A
8	Cytoskeleton remodeling_Neurofilaments41	9.7	TUBB2A, TUBB, TUBA1C, VIM
9	Regulation of CFTR activity (norm and CF)41	9.7	ADCY1, TUBB2A, TUBB, TUBA1C
10	Cytoplasmic microtubules10	9.7	TUBB2A, TUBB, TUBA1C, VIM
11	Pathogenic Escherichia coli infection20	9.7	TUBB2A, TUBB, TUBA1C
12	Cell adhesion_Gap junctions41	9.6	TUBA1C, TUBB, TUBB2A
13	Selected targets of GCR-alpha10	9.5	IL4, TUBB, TNFSF11
14	OX40 Pathway36	9.5	IL2, IL4, IL5
15	Allograft rejection20	9.4	IL2, IL4, IL5
16	Cytoskeleton remodeling Slit-Robo signaling10	9.4	TUBB, TUBA1C, TUBB2A
17	Cytoskeletal Signaling3	9.3	VIM, CALD1, TUBB, KRT8, KRT7
18	Cytoskeleton remodeling Keratin filaments10	9.3	VIM, TUBA1C, TUBB, TUBB2A, KRT8, KRT7
19	Cytoskeleton remodeling_Keratin filaments41	9.3	KRT7, KRT8, TUBB2A, TUBB, TUBA1C, VIM
20	Intestinal immune network for IgA production20	9.3	IL2, IL4, IL5
21	Autoimmune thyroid disease20	9.2	IL2, IL4, IL5
22	Molecular Mechanisms of Cancer36	8.9	ADCY1, SOX9, TNFSF11, TUBB2A, IL5, IL2
23	Immune response_MIF-mediated glucocorticoid regulation41	8.8	PTGS2, IL8, IL2
24	Immune response MIF-mediated glucocorticoid regulation10	8.8	PTGS2, IL8, IL2
25	Cytokine Network36	8.7	IL8, IL5, IL4, IL2
26	NFAT Signaling and Lymphocyte Interactions36	8.6	IL8, IL5, IL4, IL2
27	PGC1Alpha Pathway36	8.6	IL8, IL5, IL4, IL2
28	SOCS Pathway36	8.5	IL8, IL5, IL4, IL2
29	PEDF Induced Signaling36	8.2	TNFSF11, IL8, IL5, IL4, IL2
30	IL-6 Pathway36	8.2	TNFSF11, IL8, IL5, IL4, IL2
31	STAT3 Pathway36	8.2	TNFSF11, IL8, IL5, IL4, IL2
32	Cytokine-cytokine receptor interaction20	8.1	TNFSF11, IL8, IL5, IL4, IL2
33	PAK Pathway36	8.1	TNFSF11, IL8, IL5, IL4, IL2
34	Rho Family GTPases36	7.7	TNFSF11, IL8, IL5, IL4, IL2, VIM
35	MIF Mediated Glucocorticoid Regulation36	7.6	PTGS2, TNFSF11, IL8, IL5, IL4, IL2
36	MIF Regulation of Innate Immune Cells36	7.6	PTGS2, TNFSF11, IL8, IL5, IL4, IL2
37	all-trans-Retinoic Acid Signaling in Brain36	7.6	PTGS2, TNFSF11, IL8, IL5, IL4, IL2
38	Endothelin-1 Signaling Pathway36	7.6	PTGS2, TNFSF11, IL8, IL5, IL4, IL2
39	ERK Signaling36	7.5	ADCY1, TNFSF11, IL8, IL5, IL4, IL2

Compounds related to chondroblastoma according to GeneDecks:

(show top 50)    (show all 105)

id	Compound	Score	Top Affiliating Genes
1	b 72332	9.9	KRT7, KRT8, S100A1, VIM
2	pge232	9.8	TNFSF11, IL5, ADCY1
3	tartrate32	9.7	TNFSF11, PTHLH, VIM
4	olopatadine32 9 9	11.6	S100A1, S100A2, IL8
5	nocodazole32 42 9 9	12.6	TUBB2A, VIM, TUBA1C, PTHLH, TUBB
6	colchicine32 9 9	11.5	CHKB, PTHLH, TUBB, VIM
7	estrogen32	9.5	SERPINA3, KRT8, TUBB, S100A1, CHKB
8	retinoic acid32 42 18	11.5	KRT8, ADAMTS5, SOX9, PTHLH, KRT7, IL5
9	c-d4t32	9.5	IL4, IL5, IL2
10	hematoxylin32	9.5	KRT7, VIM, S100A1, KRT8
11	con a32	9.2	IL4, IL2, IL5, SERPINA3
12	glycogen32 18	10.2	KRT7, PTHLH, S100A1, CHKB, VIM, KRT8
13	lenalidomide32 9 9	11.2	PTGS2, TNFSF11, IL2
14	urea32 9 18 9	12.2	TNFSF11, KRT8, CHKB, TUBB, SERPINA3
15	thyroxine32 18	10.2	SERPINA3, PTHLH, CHKB, IL4, IL5
16	glatiramer acetate32 9 9	11.2	IL5, IL4, IL2
17	salbutamol32 34 9 18 9	13.1	IL8, CHKB, IL5, ADCY1
18	nedocromil sodium32	9.1	IL5, IL8, IL4
19	isoproterenol32 9 9	11.1	ADCY1, PTHLH, VIM, IL5
20	methotrexate32 34 42 9 9	13.0	TNFSF11, SERPINA3, VIM, CHKB, IL5, KRT7
21	mip 1alpha32	8.9	IL8, TNFSF11, IL4
22	ionomycin32	8.8	ADCY1, SERPINA3, IL2, IL4, IL5, PTHLH
23	oxygen32 18	9.8	CHKB, TNFSF11, PTGS2, SERPINA3, TUBB
24	atp32	8.7	CHKB, ATP5B, ADCY1, HK2, PTHLH, TNFSF11
25	salmeterol32 42 9 9	11.7	IL8, IL5, IL4, IL2
26	il-1232	8.7	IL8, IL2, IL4, IL5
27	gm-csf32	8.7	IL8, IL2, IL4, IL5
28	polyinosinic-polycytidylic acid32	8.7	IL2, IL4, IL5, IL8
29	azathioprine32 34 9 9	11.7	IL2, PTHLH, TNFSF11, IL4, CHKB, VIM
30	il 1032	8.6	IL8, IL5, IL4, IL2
31	vegf32	8.6	PTHLH, KRT8, CHKB, KRT7, HK2, SOX9
32	lactate32	8.4	HK2, PTHLH, VIM, KRT8, IL8, TUBB
33	neopterin32	8.3	IL2, IL4, IL8, CHKB
34	testosterone32 9 18 9	11.3	KRT8, PTHLH, TNFSF11, TUBB, IL5, CHKB
35	creatinine32	8.3	HK2, TUBB, SERPINA3, VIM, CHKB, TNFSF11
36	hydrocortisone32 9 9	10.2	IL8, IL5, IL4, VIM, IL2, PTHLH
37	arginine32	8.2	VIM, SERPINA3, ADCY1, CHKB, IL4, IL5
38	heparin32 9 18 9	11.1	ADAMTS5, PTHLH, IL5, CHKB, VIM, SERPINA3
39	adenylate32	8.1	VIM, ADCY1, PTHLH, TUBB, IL5, IL4
40	indomethacin32 9 9	10.0	TNFSF11, IL5, IL4, IL2, VIM, PTGS2
41	herbimycin a32 42	8.9	IL2, PTGS2, IL8, IL5, IL4
42	histamine32 18	8.8	IL8, IL5, IL4, ADCY1, VIM, IL2
43	sb 20358032 42	8.7	PTGS2, IL8, IL5, TNFSF11, IL4, VIM
44	actinomycin d32	7.7	IL2, IL4, IL8, PTGS2, PTHLH, KRT8
45	genistein32 9 18 9	10.5	IL5, IL8, TNFSF11, PTGS2, KRT8, VIM
46	paraffin32	7.3	VIM, SERPINA3, CHKB, HK2, KRT7, KRT8
47	cysteine32	6.9	TUBB, IL5, SERPINA3, VIM, S100A1, S100A2
48	serine32	6.9	TUBB, SERPINA3, PTHLH, KRT8, HK2, SOX9
49	cycloheximide32	6.8	PTGS2, IL8, IL5, IL4, VIM, KRT8
50	dexamethasone32 42 34 9 9	10.5	SOX9, PTHLH, SERPINA3, TNFSF11, IL5, PTGS2

Biological processes related to chondroblastoma according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein polymerization	GO:051258	9.8	TUBB2A, TUBB, TUBA1C
2	cytoskeleton-dependent intracellular transport	GO:030705	9.8	TUBB, TUBA1C
3	positive regulation of isotype switching to IgG isotypes	GO:048304	9.4	IL4, IL2
4	positive regulation of immunoglobulin secretion	GO:051024	9.3	IL2, IL5
5	positive regulation of B cell proliferation	GO:030890	9.2	IL2, IL4, IL5
6	cellular component movement	GO:006928	8.1	VIM, IL8, CALD1, TUBB, PTGS2
7	immune response	GO:006955	7.8	IL2, IL4, IL5, IL8, TNFSF11

Molecular functions related to chondroblastoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	8.9	TUBA1C, TUBB, TUBB2A, KRT8, KRT7
2	cytokine activity	GO:005125	8.7	IL2, IL4, IL5, TNFSF11