MCID: CHN004
MIFTS: 43

Chondroblastoma malady

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

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Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 10 45 47 12 36 65
 
Chondroblastoma of Bone 10

Classifications:



External Ids:

Disease Ontology10 DOID:2649
MeSH36 D002804
NCIt42 C2945
UMLS65 C0008441

Summaries for Chondroblastoma

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Wikipedia:68 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to hemorrhagic fever and kartagener syndrome, and has symptoms including pain An important gene associated with Chondroblastoma is SOX9 (SRY-Box 9), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include bone, thyroid and breast, and related mouse phenotypes are no phenotypic analysis and endocrine/exocrine gland.

Related Diseases for Chondroblastoma

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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever10.5PTGS2, TNFSF11
2kartagener syndrome10.5PTGS2, TNFSF11
3pleomorphic adenoma carcinoma10.5PTGS2, TNFSF11
4aneurysm10.4
5goat milk allergy10.4IL4, TNFSF11
6aneurysmal bone cysts10.4
7kyphoscoliotic heart disease10.3IL4, IL5
8gonococcal bursitis10.3IL4, IL5
9status asthmaticus10.3IL4, IL5
10marcus gunn phenomenon10.3PTHLH, TNFSF11
11benign paroxysmal positional nystagmus10.3IL4, IL5
12superficial urinary bladder cancer10.3IL4, IL5
13eosinophilic gastroenteritis10.3IL4, IL5
14mobitz type ii atrioventricular block10.3IL4, IL5
15granulomatous amebic encephalitis10.3IL4, IL5
16celiac trunk compression syndrome10.3CXCL8, PTGS2
17motor peripheral neuropathy10.3IL4, IL5
18hepatitis e10.3IL4, IL5
19immunodeficiency 27b, mycobacteriosis, ad10.3CXCL8, PTGS2
20acantholytic variant squamous cell breast carcinoma10.2IL4, IL5
21ophthalmomyiasis10.2CXCL8, IL4
22fibroma10.2
23chondromyxoid fibroma10.2
24prepuce cancer10.2IL4, IL5
25central nervous system childhood germ cell tumor10.2IL5, PTGS2
26eyelid neoplasm10.2CXCL8, PTGS2
27melorheostosis10.2IL4, IL5
28hepatoid adenocarcinoma10.2IL4, IL5
29plantar nerve lesion10.2CXCL8, IL5
30gonadal disease10.2CXCL8, PTGS2
31familial hyperlipidemia10.2IL4, IL5
32chondrosarcoma10.2
33keratoconjunctivitis10.2CXCL8, IL5
34skeleto cardiac syndrome with thrombocytopenia10.1PTHLH, SOX9
35disseminated eosinophilic collagen disease10.1IL4, IL5
36enamel caries10.1IL4, IL5
37neonatal infective mastitis10.1CXCL8, IL5
38acute orbital inflammation10.1IL4, TNFSF11
39giant cell tumor10.0
40clear cell chondrosarcoma10.0
41cd45 deficiency10.0IL2, IL4
42collagenous colitis10.0IL2, IL4
43reflex sympathetic dystrophy10.0IL4, PTGS2
44pustulosis palmaris et plantaris10.0CXCL8, IL4
45chondroma10.0
46b cell deficiency10.0IL2, IL4
47vulvovaginitis10.0IL2, IL4
48blastoma10.0
49chronic conjunctivitis9.9IL2, IL4
50mansonelliasis9.9CXCL8, PTGS2

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms for Chondroblastoma

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UMLS symptoms related to Chondroblastoma:


pain

Drugs & Therapeutics for Chondroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chondroblastoma


Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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MalaCards organs/tissues related to Chondroblastoma:

33
Bone, Thyroid, Breast, Lung, Brain, Liver, Endothelial

Animal Models for Chondroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Chondroblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4IL2, IL4, PTGS2, SOX9, TNFSF11
2MP:00053798.0IL2, IL4, PTGS2, PTHLH, SOX9, TNFSF11
3MP:00053887.7IL2, IL4, IL5, PTGS2, PTHLH, SOX9
4MP:00053817.6IL2, IL4, IL5, PTGS2, PTHLH, SOX9
5MP:00053897.4IL2, IL4, IL5, PTGS2, PTHLH, SOX9
6MP:00053977.1IL2, IL4, IL5, PTGS2, PTHLH, SOX9
7MP:00053876.8IL2, IL4, IL5, PTGS2, PTHLH, SOX9
8MP:00053786.7HK2, IL2, IL4, IL5, PTGS2, PTHLH

Publications for Chondroblastoma

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Articles related to Chondroblastoma:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. (27067177)
2016
2
Chondroblastoma of sella and anterior cranial fossa base. (26394622)
2016
3
Chondroblastoma of bone in the extremities: a multicenter retrospective study. (26041854)
2015
4
Chondroblastoma-like osteosarcoma. (25143130)
2014
5
Chondroblastoma of the distal phalanx. (24810830)
2014
6
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
7
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
8
Chondroblastoma of the talus: a case report and literature review. (22064125)
2012
9
Chondroblastoma of squamous part of the temporo-parietal region of skull vault: a case report and review of literature. (22536566)
2012
10
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
11
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
12
Chondroblastoma of the temporal bone. (21504272)
2011
13
Osteochondral allograft in a femoral head chondroblastoma: a case report. (20544654)
2010
14
Recurrent and aggressive chondroblastoma: a case report. (18306552)
2007
15
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
16
Pathologic quiz case: a 33-year-old woman with a large temporal mass. Chondroblastoma of the skull. (15794684)
2005
17
Chondroblastoma of bone--not a " benign disease": clinico-pathologic observations on sixty cases. (16295467)
2004
18
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
19
Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting. (11951204)
2002
20
Local recurrence of chondroblastoma. (11315800)
2001
21
Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. (11687691)
2001
22
Recurrent benign chondroblastoma at the distal end of the radius. (10190620)
1999
23
Chondroblastoma-like osteosarcoma. (10192265)
1999
24
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
25
Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy. (10591928)
1999
26
MRI characteristics of chondroblastoma. (8549042)
1996
27
Inflammatory reaction in chondroblastoma. (8738003)
1996
28
Arthroscopic resection of a chondroblastoma in the knee. (7794436)
1995
29
MR of benign chondroblastoma of the temporal bone. (7726093)
1995
30
Chondroblastoma of the rib with widespread bone metastases. (7698736)
1994
31
Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. (1384228)
1992
32
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
33
Chondroblastoma of bone. (2197612)
1990
34
Epidermal nevus syndrome: report of association with chondroblastoma of bone. (2616394)
1989
35
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
36
Chondroblastoma of the patella with a pathologic fracture. A case report. (3503985)
1987
37
Aggressive chondroblastoma of the femoral head. A case report. (3563736)
1987
38
Chondroblastoma of the sacrum. A case report. (3788507)
1986
39
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
40
Chondroblastoma of the rib. Report of a case. (4691660)
1973
41
Chondroblastoma--the nature of the basic cell. A study by means of histochemistry, tissue culture, electron microscopy, and autoradiography. (4260603)
1972
42
Benign chondroblastoma. A study of 125 cases. (5051664)
1972
43
Rare localization of chondroblastoma. (4258839)
1971
44
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
45
Benign chondroblastoma of tibia. (5507062)
1970
46
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
47
BENIGN CHONDROBLASTOMA OF MANDIBULAR CONDYLE: REPORT OF CASE. (14155482)
1964
48
Chondroblastoma. (14409207)
1959
49
Benign chondroblastoma of bone. (14895976)
1952
50

Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6PTHLH, TNFSF11
29.5IL4, IL5
39.1CXCL8, PTGS2, TNFSF11
4
Show member pathways
8.7IL2, IL4, IL5
58.7IL2, IL4, IL5
68.7IL2, IL4, IL5
78.7IL2, IL4, IL5
88.7IL2, IL4, IL5
98.7IL2, IL4, IL5
108.7IL2, IL4, IL5
118.6CXCL8, IL2, PTGS2
128.3CXCL8, IL2, IL4, SOX9
138.1CXCL8, IL2, IL4, IL5
14
Show member pathways
8.1CXCL8, IL2, IL4, IL5
15
Show member pathways
7.7CXCL8, IL2, IL4, IL5, TNFSF11
16
Show member pathways
7.6CXCL8, IL2, IL4, IL5, PTGS2
17
Show member pathways
7.3CXCL8, IL2, IL4, IL5, PTGS2, TNFSF11
18
Show member pathways
7.0CXCL8, IL2, IL4, IL5, PTGS2, SOX9

GO Terms for genes affiliated with Chondroblastoma

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Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell adhesionGO:00301559.9CXCL8, SOX9
2positive regulation of T cell differentiationGO:00455829.8IL2, IL4
3extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.8IL2, IL4
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.7IL2, IL4
5positive regulation of T cell proliferationGO:00421029.7IL2, IL4
6positive regulation of isotype switching to IgG isotypesGO:00483049.6IL2, IL4
7positive regulation of B cell proliferationGO:00308909.2IL2, IL4, IL5
8positive regulation of protein phosphorylationGO:00019349.1IL2, IL4, SOX9
9positive regulation of transcription from RNA polymerase II promoterGO:00459448.6IL2, IL4, SOX9, TNFSF11
10positive regulation of cell proliferationGO:00082847.8IL2, IL4, IL5, PTHLH, SOX9
11immune responseGO:00069557.7CXCL8, IL2, IL4, IL5, TNFSF11

Sources for Chondroblastoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet