MCID: CHN004
MIFTS: 38

Chondroblastoma malady

Rare diseases, Cancer diseases, Bone diseases categories

Aliases & Classifications for Chondroblastoma

About this section

Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 10 45 47 12 65 36
 
Chondroblastoma of Bone 10


Classifications:



External Ids:

Disease Ontology10 DOID:2649
NCIt42 C2945
MeSH36 D002804

Summaries for Chondroblastoma

About this section
Wikipedia:68 Chondroblastoma is a rare bone tumor, usually benign with a slow-growing nature. more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to aneurysm and aneurysmal bone cysts. An important gene associated with Chondroblastoma is SOX9 (SRY (Sex Determining Region Y)-Box 9), and among its related pathways are Osteoblast Signaling and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Related Diseases for Chondroblastoma

About this section

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm10.7
2aneurysmal bone cysts10.7
3fibroma10.5
4chondromyxoid fibroma10.5
5chondrosarcoma10.4
6clear cell chondrosarcoma10.3
7giant cell tumor10.3
8chondroma10.2
9visceral neuropathy familial10.2IL2, IL4
10cd45 deficiency10.2IL2, IL4
11hemorrhagic fever10.2PTGS2, TNFSF11
12microsporidiosis10.2IL2, IL4
13mechanical entropion10.2IL2, IL5
14trench fever10.2IL4, IL5
15epithelioid cell melanoma10.2IL4, IL5
16mixed eosinophil-basophil adenoma10.2IL4, IL5
17status asthmaticus10.2IL4, IL5
18nut allergic reaction10.2IL4, IL5
19colitis10.2IL2, IL4
20angiokeratoma circumscriptum10.2CXCL8, TNFSF11
21coenurosis10.2IL4, IL5
22scleroderma10.2IL4, IL5
23malignant sertoli-leydig cell tumor of ovary10.2CXCL8, IL2
24thalamic neoplasm10.2IL4, IL5
25bagassosis10.2CXCL8, IL2
26benign deep fibrous histiocytoma10.2IL4, IL5
27eosinophilic gastroenteritis10.2IL4, IL5
28chronic cystitis10.2IL4, IL5
29basidiobolomycosis10.2CXCL8, IL4
30opisthorchiasis10.2CXCL8, IL2
31neonatal urinary tract infectious disease10.2IL4, IL5
32chronic tubotympanic suppurative otitis media10.2CXCL8, IL2
33cervicitis10.2
34periostitis10.2
35synovitis10.2
36morgagni cataract10.2IL4, IL5
37acute leukemia of ambiguous lineage10.2IL2, IL4
38papilledema10.2CXCL8, IL4
39anal canal carcinoma10.2IL4, IL5
40verrucous nevus acanthokeratolytic10.2IL4, IL5
41cicatricial entropion10.2CXCL8, IL4
42pes anserinus tendinitis or bursitis10.2CXCL8, IL4
43hughes-stovin syndrome10.2IL4, IL5
44plantar fasciitis10.2CXCL8, IL2
45plantar nerve lesion10.1CXCL8, IL5
46epithelioid malignant peripheral nerve sheath tumor10.1IL4, IL5
47conjunctivitis10.1IL4, IL5
48refractory hairy cell leukemia10.1IL2, IL4
49chondrocalcinosis10.1IL4, IL5
50nasopharyngeal disease10.1IL4, IL5

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms for Chondroblastoma

About this section

Drugs & Therapeutics for Chondroblastoma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chondroblastoma


Cochrane evidence based reviews: Chondroblastoma

Genetic Tests for Chondroblastoma

About this section

Anatomical Context for Chondroblastoma

About this section

MalaCards organs/tissues related to Chondroblastoma:

33
Bone, Lung, Testes, Thyroid, Cortex

Animal Models for Chondroblastoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Chondroblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6IL2, IL4, PTGS2, SOX9, TNFSF11
2MP:00053818.0IL2, IL4, IL5, PTGS2, PTH1R, SOX9
3MP:00053887.7IL2, IL4, IL5, PTGS2, PTH1R, SOX9
4MP:00053897.7IL2, IL4, IL5, PTGS2, SOX9, TNFSF11
5MP:00053787.0HK2, IL2, IL4, IL5, PTGS2, PTH1R
6MP:00053876.8CXCL8, IL2, IL4, IL5, PTGS2, SOX9
7MP:00053976.6CXCL8, IL2, IL4, IL5, PTGS2, SOX9

Publications for Chondroblastoma

About this section

Articles related to Chondroblastoma:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Chondroblastoma-like osteosarcoma. (25143130)
2014
2
Chondroblastoma of the distal phalanx. (24810830)
2014
3
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
4
Chondroblastoma of the distal femur resected through a small fenestra via computed tomography navigation and endoscopy: a case report. (23805921)
2013
5
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
6
Chondroblastoma of the talus: a case report and literature review. (22064125)
2012
7
Chondroblastoma of squamous part of the temporo-parietal region of skull vault: a case report and review of literature. (22536566)
2012
8
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
9
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
10
Chondroblastoma of the temporal bone. (21504272)
2011
11
Osteochondral allograft in a femoral head chondroblastoma: a case report. (20544654)
2010
12
Recurrent and aggressive chondroblastoma: a case report. (18306552)
2007
13
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
14
Pathologic quiz case: a 33-year-old woman with a large temporal mass. Chondroblastoma of the skull. (15794684)
2005
15
Chondroblastoma of bone--not a " benign disease": clinico-pathologic observations on sixty cases. (16295467)
2004
16
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
17
Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting. (11951204)
2002
18
Local recurrence of chondroblastoma. (11315800)
2001
19
Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. (11687691)
2001
20
Recurrent benign chondroblastoma at the distal end of the radius. (10190620)
1999
21
Chondroblastoma-like osteosarcoma. (10192265)
1999
22
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
23
Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy. (10591928)
1999
24
MRI characteristics of chondroblastoma. (8549042)
1996
25
Inflammatory reaction in chondroblastoma. (8738003)
1996
26
Arthroscopic resection of a chondroblastoma in the knee. (7794436)
1995
27
MR of benign chondroblastoma of the temporal bone. (7726093)
1995
28
Chondroblastoma of the rib with widespread bone metastases. (7698736)
1994
29
Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. (1384228)
1992
30
Electron microscopic and immunohistochemical studies on chondroblastoma]. (1512479)
1992
31
Case report: metadiaphyseal chondroblastoma. (1737428)
1992
32
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
33
Chondroblastoma of bone. (2197612)
1990
34
Epidermal nevus syndrome: report of association with chondroblastoma of bone. (2616394)
1989
35
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
36
Chondroblastoma of the patella with a pathologic fracture. A case report. (3503985)
1987
37
Aggressive chondroblastoma of the femoral head. A case report. (3563736)
1987
38
Chondroblastoma of the sacrum. A case report. (3788507)
1986
39
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
40
Chondroblastoma of the rib. Report of a case. (4691660)
1973
41
Chondroblastoma--the nature of the basic cell. A study by means of histochemistry, tissue culture, electron microscopy, and autoradiography. (4260603)
1972
42
Benign chondroblastoma. A study of 125 cases. (5051664)
1972
43
Rare localization of chondroblastoma. (4258839)
1971
44
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
45
Benign chondroblastoma of tibia. (5507062)
1970
46
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
47
BENIGN CHONDROBLASTOMA OF MANDIBULAR CONDYLE: REPORT OF CASE. (14155482)
1964
48
Chondroblastoma. (14409207)
1959
49
Benign chondroblastoma of bone. (14895976)
1952
50
Benign chondroblastoma of bone; unusual localization in femoral capital epiphysis. (18136916)
1949

Variations for Chondroblastoma

About this section

Expression for genes affiliated with Chondroblastoma

About this section
Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

About this section

Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PTH1R, TNFSF11
29.3IL4, IL5
38.9IL2, IL4, IL5
48.9IL2, IL4, IL5
5
Show member pathways
8.9IL2, IL4, IL5
68.9IL2, IL4, IL5
78.8CXCL8, PTGS2, TNFSF11
88.7CXCL8, IL2, PTGS2
98.6IL2, IL4, PTGS2, TNFSF11
108.4CXCL8, IL2, IL4, SOX9
11
Show member pathways
8.1CXCL8, IL2, IL4, IL5
128.1CXCL8, IL2, IL4, IL5
13
Show member pathways
7.7CXCL8, IL2, IL4, IL5, TNFSF11
14
Show member pathways
7.5CXCL8, IL2, IL4, IL5, PTGS2
15
Show member pathways
7.2CXCL8, IL2, IL4, IL5, PTGS2, TNFSF11
16
Show member pathways
6.9CXCL8, IL2, IL4, IL5, PTGS2, SOX9

GO Terms for genes affiliated with Chondroblastoma

About this section

Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.7CXCL8, IL2, IL4, IL5, TNFSF11

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.3SOX9, TNFSF11
2bone resorptionGO:004545310.2PTH1R, TNFSF11
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1IL2, IL4
4extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.1IL2, IL4
5positive regulation of activated T cell proliferationGO:004210410.0IL2, IL4
6positive regulation of isotype switching to IgG isotypesGO:004830410.0IL2, IL4
7positive regulation of T cell differentiationGO:004558210.0IL2, IL4
8positive regulation of immunoglobulin secretionGO:005102410.0IL2, IL5
9chondrocyte differentiationGO:00020629.9PTH1R, SOX9
10positive regulation of protein phosphorylationGO:00019349.6IL2, IL4, SOX9
11bone mineralizationGO:00302829.5PTGS2, PTH1R
12positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL4, IL5, TNFSF11
13positive regulation of B cell proliferationGO:00308909.4IL2, IL4, IL5
14ossificationGO:00015039.2PTH1R, SOX9, TNFSF11
15negative regulation of cell proliferationGO:00082858.6CXCL8, PTGS2, PTH1R, SOX9
16immune responseGO:00069557.9CXCL8, IL2, IL4, IL5, TNFSF11
17positive regulation of cell proliferationGO:00082847.7IL2, IL4, IL5, PTGS2, PTH1R, SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.9IL2, IL4, IL5
2cytokine activityGO:00051258.5IL2, IL4, IL5, TNFSF11

Sources for Chondroblastoma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet