MCID: CHN004
MIFTS: 40

Chondroblastoma malady

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 12 50 52 42 14 69
Chondroblastoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2649
MeSH 42 D002804
NCIt 47 C2945
UMLS 69 C0008441

Summaries for Chondroblastoma

MalaCards based summary : Chondroblastoma, also known as chondroblastoma of bone, is related to blastoma and aneurysm, and has symptoms including pain An important gene associated with Chondroblastoma is SOX9 (SRY-Box 9), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include bone, lung and testes, and related phenotypes are growth/size/body region and digestive/alimentary

Wikipedia : 71 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

Related Diseases for Chondroblastoma

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 blastoma 10.8
2 aneurysm 10.3
3 aneurysmal bone cysts 10.3
4 binocular vision disease 10.3 PTH1R TNFSF11
5 hepatic fibrosis renal cysts mental retardation 10.2 PTGS2 TNFSF11
6 nasal cavity inverting papilloma 10.2 CXCL8 TNFSF11
7 common peroneal nerve lesion 10.1 CXCL8 IL5
8 primary non-gestational choriocarcinoma of ovary 10.1 CXCL8 PTGS2
9 middle lobe syndrome 10.1 CXCL8 IL5
10 fibroma 10.1
11 chondromyxoid fibroma 10.1
12 infectious anterior uveitis 10.1 CXCL8 IL5
13 thanatophoric dysplasia, type i 10.1 FGFR1 PTH1R SOX9
14 t cell immunodeficiency primary 10.0 FGFR1 SOX9
15 chondrosarcoma 10.0
16 conidiobolomycosis 10.0 CXCL8 IL4
17 psychotic disorder 10.0 CXCL8 IL4
18 retinal vascular disease 10.0 CXCL8 IL4
19 marasmus 10.0 IL4 IL5
20 papillary squamous carcinoma 10.0 IL4 IL5
21 lens-induced iridocyclitis 10.0 IL4 IL5
22 spastic paraplegia 3a, autosomal dominant 10.0 IL4 IL5
23 thelaziasis 10.0 IL4 IL5
24 chancroid 10.0 CXCL8 IL4
25 hypersensitivity vasculitis 10.0 IL4 IL5
26 lymphoblastic leukemia 10.0 IL4 IL5
27 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.0 IL4 IL5
28 urethral intrinsic sphincter deficiency 10.0 IL4 IL5
29 bone peripheral neuroepithelioma 10.0 IL4 IL5
30 indian plum allergy 10.0 IL4 IL5
31 luminal breast carcinoma 10.0 IL4 IL5
32 lactose intolerance 10.0 IL4 IL5
33 conjunctival concretion 10.0 CXCL8 IL5 PTGS2
34 acute gonococcal prostatitis 9.9 IL4 IL5
35 cerebral primitive neuroectodermal tumor 9.9 IL4 IL5
36 hidradenitis 9.9 CXCL8 PTGS2
37 askin's tumor 9.9 IL4 IL5
38 apricot allergy 9.9 IL4 IL5
39 trachea leiomyoma 9.9 IL4 IL5
40 visceral steatosis 9.9 IL4 IL5
41 birth defects 9.9 CXCL8 FGFR1 IL5
42 cutaneous fibrous histiocytoma 9.9 IL4 IL5
43 clear cell chondrosarcoma 9.9
44 giant cell tumor 9.9
45 osteonecrosis 9.9 CXCL8 PTGS2 SOX9 TNFSF11
46 autosomal recessive type iv ehlers-danlos syndrome 9.9 CXCL8 IL4 TNFSF11
47 histoplasmosis retinitis 9.9 IL4 IL5
48 allescheriosis 9.9 CA10 IL4 IL5
49 lymphocytic gastritis 9.9 IL4 IL5
50 chondroma 9.8

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to Chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

UMLS symptoms related to Chondroblastoma:


pain

MGI Mouse Phenotypes related to Chondroblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 FGFR1 HK2 IL4 IL5 PTGS2 PTH1R
2 digestive/alimentary MP:0005381 9.91 IL4 IL5 PTGS2 PTH1R SOX9 FGFR1
3 embryo MP:0005380 9.88 FGFR1 HK2 IL5 PTGS2 PTH1R SOX9
4 craniofacial MP:0005382 9.85 FGFR1 IL4 PTH1R SOX9 TNFSF11
5 normal MP:0002873 9.73 SOX9 TNFSF11 FGFR1 HK2 IL4 PTGS2
6 no phenotypic analysis MP:0003012 9.72 FGFR1 IL4 PTGS2 SOX9 TNFSF11
7 reproductive system MP:0005389 9.63 FGFR1 IL4 IL5 PTGS2 SOX9 TNFSF11
8 respiratory system MP:0005388 9.43 IL4 IL5 PTGS2 PTH1R SOX9 TNFSF11
9 skeleton MP:0005390 9.1 FGFR1 IL4 PTGS2 PTH1R SOX9 TNFSF11

Drugs & Therapeutics for Chondroblastoma

Search Clinical Trials , NIH Clinical Center for Chondroblastoma

Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

MalaCards organs/tissues related to Chondroblastoma:

39
Bone, Lung, Testes, Thyroid, Cortex

Publications for Chondroblastoma

Articles related to Chondroblastoma:

(show top 50) (show all 397)
id Title Authors Year
1
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. ( 27798068 )
2016
2
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
3
Malignant chondroblastoma of extraskeletal origin. ( 27127749 )
2016
4
Epigenetics: Histone mutations reprogramme chondroblastoma. ( 27339705 )
2016
5
Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls. ( 27011442 )
2016
6
What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? A Report on Functional Results, Arthritis, and Arthroplasty. ( 26831477 )
2016
7
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. ( 27966029 )
2016
8
Temporal bone chondroblastoma totally invisible on MRI. ( 26743837 )
2016
9
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use. ( 26726978 )
2016
10
Reconstruction with double pedicel fibular graft and ankle arthrodesis for aggressive chondroblastoma in the distal tibia. ( 27176605 )
2016
11
A rare case of chondroblastoma of the acromion. ( 27956080 )
2016
12
Chondroblastoma of sella and anterior cranial fossa base. ( 26394622 )
2016
13
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. ( 27299121 )
2016
14
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. ( 27067177 )
2016
15
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. ( 26844533 )
2016
16
Operative treatment of chondroblastoma: a study of 11 cases. ( 26984656 )
2016
17
Benign chondroblastoma on fine-needle aspiration smears: A seven-case experience and review of the literature. ( 25914148 )
2015
18
Atypical giant chondroblastoma mimicking a chondrosarcoma. ( 26458670 )
2015
19
Chondroblastoma-like osteosarcoma: a case report and review. ( 25492634 )
2015
20
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. ( 27408892 )
2015
21
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. ( 26457357 )
2015
22
Calcaneal chondroblastoma with pathologic fracture and recurrence. ( 25624038 )
2015
23
Chondroblastoma of the Clivus: Case Report and Review. ( 26623238 )
2015
24
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. ( 25647721 )
2015
25
Temporal Bone Localized Chondroblastoma. ( 26517458 )
2015
26
Arthroscopic burring of exposed cement following curettage and cavity filling cementation for chondroblastoma of the proximal tibia. ( 25750896 )
2015
27
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. ( 26714409 )
2015
28
Chondroblastoma of the scaphoid: A case report. ( 26458718 )
2015
29
Chondroblastoma of bone in the extremities: a multicenter retrospective study. ( 26041854 )
2015
30
Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. ( 25432292 )
2015
31
Surface-based chondroblastoma of the tibia: a unique presentation. ( 25851832 )
2015
32
Chondroblastoma-like chondroma of the hand: case report. ( 24656394 )
2014
33
Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist. ( 24876212 )
2014
34
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. ( 24849285 )
2014
35
Chondroblastoma of the knee treated with resection and osteochondral allograft reconstruction. ( 25548701 )
2014
36
Chondroblastoma: a clinico-pathological analysis. ( 25523724 )
2014
37
Chondroblastoma of the distal phalanx. ( 24810830 )
2014
38
Chondroblastoma of the navicular bone. ( 25780542 )
2014
39
Chondroblastoma of the patella with aneurysmal bone cyst. ( 24683664 )
2014
40
Chondroblastoma of the medial cuneiform bone in a 32-year-old woman. ( 25072961 )
2014
41
What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? ( 25115583 )
2014
42
CORR InsightsAr: what are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? ( 25163690 )
2014
43
Fine needle aspiration cytology of chondroblastoma of the fibula. ( 25745297 )
2014
44
Chondroblastoma-like osteosarcoma. ( 25143130 )
2014
45
Minimally invasive technique for curettage of chondroblastoma using endoscopic technique. ( 25491613 )
2014
46
Chondroblastoma with secondary aneurysmal bone cyst of the capitate. ( 24810829 )
2014
47
Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. ( 24639947 )
2014
48
Chondroblastoma and chondromyxoid fibroma. ( 23545728 )
2013
49
A guise of osteosarcoma: Chondroblastoma-like. ( 24355968 )
2013
50
Chondroblastoma of the temporal bone. ( 23851845 )
2013

Variations for Chondroblastoma

Expression for Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for Chondroblastoma

Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 CXCL8 FGFR1 IL4 IL5 PTGS2 SOX9
2
Show member pathways
13.39 CXCL8 FGFR1 IL4 IL5 PTGS2 TNFSF11
3
Show member pathways
13.16 CXCL8 FGFR1 IL4 IL5 TNFSF11
4
Show member pathways
13.05 CXCL8 FGFR1 IL4 IL5 TNFSF11
5
Show member pathways
13.02 CXCL8 FGFR1 IL4 IL5 PTGS2 TNFSF11
6
Show member pathways
11.96 CXCL8 IL4 IL5 PTGS2
7
Show member pathways
11.92 CXCL8 IL4 IL5
8 11.73 CXCL8 IL4 PTGS2
9 11.63 CXCL8 PTGS2 TNFSF11
10 11.55 CXCL8 IL4 IL5
11 11.39 FGFR1 PTH1R SOX9
12 11.34 CXCL8 IL4 IL5
13 11.34 CXCL8 IL4 PTGS2 SOX9
14 11.2 PTH1R TNFSF11
15 11.12 IL4 IL5
16 11.12 CXCL8 IL4 PTGS2
17 11.1 IL4 IL5
18 11.07 IL4 IL5
19 10.98 IL4 IL5
20 10.83 CXCL8 PTGS2
21
Show member pathways
10.81 CXCL8 IL4 IL5 PTGS2
22 10.7 IL4 IL5
23 10.69 CXCL8 IL4 IL5 TNFSF11
24 10.66 PTH1R TNFSF11

GO Terms for Chondroblastoma

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CXCL8 IL4 IL5 TNFSF11
2 regulation of cell proliferation GO:0042127 9.7 FGFR1 PTGS2 SOX9
3 angiogenesis GO:0001525 9.69 CXCL8 FGFR1 PTGS2
4 negative regulation of cell proliferation GO:0008285 9.62 CXCL8 PTGS2 PTH1R SOX9
5 regulation of cell differentiation GO:0045595 9.56 FGFR1 SOX9
6 cell maturation GO:0048469 9.55 FGFR1 PTH1R
7 positive regulation of B cell proliferation GO:0030890 9.54 IL4 IL5
8 skeletal system development GO:0001501 9.54 FGFR1 PTH1R SOX9
9 bone mineralization GO:0030282 9.49 PTGS2 PTH1R
10 ERK1 and ERK2 cascade GO:0070371 9.48 SOX9 TNFSF11
11 positive regulation of mesenchymal cell proliferation GO:0002053 9.46 FGFR1 SOX9
12 bone resorption GO:0045453 9.43 PTH1R TNFSF11
13 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.43 IL4 IL5 TNFSF11
14 ossification GO:0001503 9.33 PTH1R SOX9 TNFSF11
15 chondrocyte differentiation GO:0002062 9.13 FGFR1 PTH1R SOX9
16 positive regulation of cell proliferation GO:0008284 9.1 FGFR1 IL4 IL5 PTGS2 PTH1R SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL4 IL5 TNFSF11

Sources for Chondroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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