MCID: CHN004
MIFTS: 40

Chondroblastoma

Categories: Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Chondroblastoma

MalaCards integrated aliases for Chondroblastoma:

Name: Chondroblastoma 12 72 49 51 41 14 69
Chondroblastoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2649
MeSH 41 D002804
NCIt 46 C2945
UMLS 69 C0008441

Summaries for Chondroblastoma

MalaCards based summary : Chondroblastoma, also known as chondroblastoma of bone, is related to chondromyxoid fibroma and clear cell chondrosarcoma, and has symptoms including pain An important gene associated with Chondroblastoma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are ERK Signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, lung and testes, and related phenotypes are embryo and growth/size/body region

Wikipedia : 72 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

Related Diseases for Chondroblastoma

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 chondromyxoid fibroma 30.4 PTH1R SOX9
2 clear cell chondrosarcoma 30.1 H3F3A H3F3B PTH1R
3 blastoma 11.0
4 aneurysm 10.4
5 aneurysmal bone cysts 10.4
6 bone giant cell sarcoma 10.4 H3F3A H3F3B
7 malignant giant cell tumor 10.3 H3F3A H3F3B
8 brain stem cancer 10.3 H3F3A H3F3B
9 adult astrocytic tumour 10.3 H3F3A H3F3B
10 diffuse intrinsic pontine glioma 10.3 H3F3A H3F3B
11 spinal cord astrocytoma 10.2 H3F3A H3F3B
12 tooth ankylosis 10.2 PTH1R TNFSF11
13 tooth resorption 10.1 PTH1R TNFSF11
14 chondrosarcoma 10.1
15 hemophilic arthropathy 10.1 PTGS2 TNFSF11
16 episodic pain syndrome, familial, 1 10.0
17 synovial chondromatosis 10.0 FGFR1 SOX9
18 giant cell tumor 10.0
19 skeletal dysplasias 10.0 PTH1R SOX9
20 chondroma 9.9
21 keratocystic odontogenic tumor 9.9 PTGS2 TNFSF11
22 adamantinoma of long bones 9.9 FGFR1 TNFSF11
23 blood group, i system 9.8
24 aging 9.8
25 meningioma, familial 9.8
26 cervicitis 9.8
27 synovitis 9.8
28 histiocytoma 9.8
29 fibrous histiocytoma 9.8
30 periostitis 9.8
31 achondroplasia 9.8 FGFR1 PTH1R SOX9
32 osteoarthritis 9.8 PTGS2 SOX9 TNFSF11
33 nevus, epidermal 9.7
34 osteoid osteoma 9.7
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
36 arthritis 9.7
37 fibrous dysplasia 9.7
38 sarcoma 9.7
39 cauda equina syndrome 9.7
40 pneumothorax 9.7
41 pigmented villonodular synovitis 9.7
42 papillary carcinoma 9.7
43 conventional central osteosarcoma 9.7
44 cerebritis 9.7
45 mesenchymal chondrosarcoma 9.7
46 thyroiditis 9.7
47 meningothelial meningioma 9.7
48 villonodular synovitis 9.7
49 enchondroma 9.7
50 osteochondroma 9.7

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to Chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

UMLS symptoms related to Chondroblastoma:


pain

MGI Mouse Phenotypes related to Chondroblastoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.87 PTGS2 PTH1R SLC2A1 SOX9 FGFR1 H3F3B
2 growth/size/body region MP:0005378 9.86 PTGS2 PTH1R SLC2A1 SOX9 FGFR1 TNFSF11
3 mortality/aging MP:0010768 9.76 PTGS2 PTH1R SLC2A1 SOX9 FGFR1 TNFSF11
4 no phenotypic analysis MP:0003012 9.35 PTGS2 SLC2A1 SOX9 FGFR1 TNFSF11
5 normal MP:0002873 9.1 PTGS2 SOX9 FGFR1 TNFSF11 H3F3B HK2

Drugs & Therapeutics for Chondroblastoma

Search Clinical Trials , NIH Clinical Center for Chondroblastoma

Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

MalaCards organs/tissues related to Chondroblastoma:

38
Bone, Lung, Testes, Thyroid, Cortex

Publications for Chondroblastoma

Articles related to Chondroblastoma:

(show top 50) (show all 417)
# Title Authors Year
1
Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review. ( 29416176 )
2018
2
Combined Autograft and Bone Cement for Painful Chondroblastoma: A Case Report. ( 29307744 )
2018
3
Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up. ( 29307095 )
2018
4
"Chondroblastoma-like" epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant. ( 29068085 )
2018
5
The effects of surgical treatment with chondroblastoma in children and adolescents in open epiphyseal plate of long bones. ( 29361956 )
2018
6
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28862242 )
2017
7
Temporal bone chondroblastoma: Imaging characteristics with pathologic correlation. ( 28736834 )
2017
8
Chondroblastoma of extra-craniofacial bones: Clinicopathological analyses of 103 cases. ( 28971570 )
2017
9
Chondroblastoma in adult age. ( 28634924 )
2017
10
Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge. ( 28834661 )
2017
11
A Rare Case of Chondroblastoma with Revision After Graft Rejection<sub>A Case Report</sub>. ( 29077506 )
2017
12
A rare probable chondroblastoma of the calcaneus in a pre-Columbian subadult from Illinois. ( 28290305 )
2017
13
Capitate Chondroblastoma: A Case Report and Review of the Literature. ( 28344536 )
2017
14
Chondroblastoma: An Update. ( 28557595 )
2017
15
Intra-axial chondroblastoma: A bony tumor in the cerebral hemisphere - A case report and review of literature. ( 28484548 )
2017
16
Lateral skull base chondroblastoma resected with facial nerve posterior transposition. ( 28502566 )
2017
17
An unusual localization of chondroblastoma: The triradiate cartilage; from a case report a reconstructive technique proposal with imaging evolution. ( 28878541 )
2017
18
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28272066 )
2017
19
Use of denosumab in recurrent chondroblastoma of the squamous temporal bone: a case report. ( 28396758 )
2017
20
Chondroblastoma of the rib in a 47-year-old man: a case report with a systematic review of literature. ( 29268433 )
2017
21
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use. ( 26726978 )
2016
22
Temporal bone chondroblastoma totally invisible on MRI. ( 26743837 )
2016
23
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. ( 27067177 )
2016
24
What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? A Report on Functional Results, Arthritis, and Arthroplasty. ( 26831477 )
2016
25
A rare case of chondroblastoma of the acromion. ( 27956080 )
2016
26
Epigenetics: Histone mutations reprogramme chondroblastoma. ( 27339705 )
2016
27
Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls. ( 27011442 )
2016
28
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. ( 27299121 )
2016
29
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. ( 27966029 )
2016
30
Reconstruction with double pedicel fibular graft and ankle arthrodesis for aggressive chondroblastoma in the distal tibia. ( 27176605 )
2016
31
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. ( 26844533 )
2016
32
Malignant chondroblastoma of extraskeletal origin. ( 27127749 )
2016
33
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
34
Operative treatment of chondroblastoma: a study of 11 cases. ( 26984656 )
2016
35
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. ( 27798068 )
2016
36
Chondroblastoma of sella and anterior cranial fossa base. ( 26394622 )
2016
37
Chondroblastoma of the Clivus: Case Report and Review. ( 26623238 )
2015
38
Arthroscopic burring of exposed cement following curettage and cavity filling cementation for chondroblastoma of the proximal tibia. ( 25750896 )
2015
39
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. ( 27408892 )
2015
40
Benign chondroblastoma on fine-needle aspiration smears: A seven-case experience and review of the literature. ( 25914148 )
2015
41
Surface-based chondroblastoma of the tibia: a unique presentation. ( 25851832 )
2015
42
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. ( 26457357 )
2015
43
Temporal Bone Localized Chondroblastoma. ( 26517458 )
2015
44
Calcaneal chondroblastoma with pathologic fracture and recurrence. ( 25624038 )
2015
45
Chondroblastoma of bone in the extremities: a multicenter retrospective study. ( 26041854 )
2015
46
Chondroblastoma-like osteosarcoma: a case report and review. ( 25492634 )
2015
47
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. ( 26714409 )
2015
48
Atypical giant chondroblastoma mimicking a chondrosarcoma. ( 26458670 )
2015
49
Chondroblastoma of the scaphoid: A case report. ( 26458718 )
2015
50
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. ( 25647721 )
2015

Variations for Chondroblastoma

Expression for Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for Chondroblastoma

GO Terms for Chondroblastoma

Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.16 H3F3A H3F3B
2 nuclear nucleosome GO:0000788 8.96 H3F3A H3F3B
3 protein complex GO:0043234 8.92 H3F3A H3F3B PTGS2 SOX9

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.73 FGFR1 PTGS2 PTH1R SOX9
2 regulation of cell proliferation GO:0042127 9.71 FGFR1 PTGS2 SOX9
3 negative regulation of gene expression, epigenetic GO:0045814 9.58 H3F3A H3F3B
4 regulation of cell differentiation GO:0045595 9.57 FGFR1 SOX9
5 cell maturation GO:0048469 9.56 FGFR1 PTH1R
6 chromatin silencing at rDNA GO:0000183 9.55 H3F3A H3F3B
7 skeletal system development GO:0001501 9.54 FGFR1 PTH1R SOX9
8 bone mineralization GO:0030282 9.52 PTGS2 PTH1R
9 positive regulation of mesenchymal cell proliferation GO:0002053 9.51 FGFR1 SOX9
10 nucleosome assembly GO:0006334 9.5 H3F3A H3F3B SOX9
11 ERK1 and ERK2 cascade GO:0070371 9.49 SOX9 TNFSF11
12 telomere organization GO:0032200 9.48 H3F3A H3F3B
13 DNA replication-independent nucleosome assembly GO:0006336 9.46 H3F3A H3F3B
14 ossification GO:0001503 9.43 PTH1R SOX9 TNFSF11
15 bone resorption GO:0045453 9.4 PTH1R TNFSF11
16 cellular response to mechanical stimulus GO:0071260 9.33 PTGS2 SLC2A1 SOX9
17 brain development GO:0007420 9.26 CA10 FGFR1 H3F3A H3F3B
18 chondrocyte differentiation GO:0002062 8.8 FGFR1 PTH1R SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.62 H3F3A H3F3B

Sources for Chondroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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