MCID: CHN004
MIFTS: 41

Chondroblastoma malady

Rare diseases, Bone diseases categories

Summaries for Chondroblastoma

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Wikipedia:65 Chondroblastoma is a rare bone tumor, usually benign with a slow-growing nature. more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to chondrosarcoma and aneurysm. An important gene associated with Chondroblastoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways is Endochondral Ossification. The compounds isotretinoin and phosphorus have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and cortex, and related mouse phenotype limbs/digits/tail.

Aliases & Classifications for Chondroblastoma

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Chondroblastoma, Aliases & Descriptions:

Name: Chondroblastoma 10 43 12 45 62
 
Chondroblastoma of Bone 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology10 DOID:2649
NCIt40 C2945
MeSH35 D002804

Related Diseases for Chondroblastoma

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Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms for Chondroblastoma

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Drugs & Therapeutics for Chondroblastoma

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Drug clinical trials:

Search ClinicalTrials for Chondroblastoma

Search NIH Clinical Center for Chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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MalaCards organs/tissues related to Chondroblastoma:

33
Bone, Lung, Cortex, Thyroid, Testes

Animal Models for Chondroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Chondroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7CHKB, SOX9, PTHLH

Publications for Chondroblastoma

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Articles related to Chondroblastoma:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Chondroblastoma-like osteosarcoma. (25143130)
2014
2
Chondroblastoma of the distal phalanx. (24810830)
2014
3
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
4
Chondroblastoma of the distal femur resected through a small fenestra via computed tomography navigation and endoscopy: a case report. (23805921)
2013
5
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
6
Chondroblastoma of the talus: a case report and literature review. (22064125)
2012
7
Chondroblastoma of squamous part of the temporo-parietal region of skull vault: a case report and review of literature. (22536566)
2012
8
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
9
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
10
Chondroblastoma of the temporal bone. (21504272)
2011
11
Osteochondral allograft in a femoral head chondroblastoma: a case report. (20544654)
2010
12
Recurrent and aggressive chondroblastoma: a case report. (18306552)
2007
13
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
14
Pathologic quiz case: a 33-year-old woman with a large temporal mass. Chondroblastoma of the skull. (15794684)
2005
15
Chondroblastoma of bone--not a " benign disease": clinico-pathologic observations on sixty cases. (16295467)
2004
16
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
17
Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting. (11951204)
2002
18
Local recurrence of chondroblastoma. (11315800)
2001
19
Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. (11687691)
2001
20
Recurrent benign chondroblastoma at the distal end of the radius. (10190620)
1999
21
Chondroblastoma-like osteosarcoma. (10192265)
1999
22
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
23
Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy. (10591928)
1999
24
MRI characteristics of chondroblastoma. (8549042)
1996
25
Inflammatory reaction in chondroblastoma. (8738003)
1996
26
Arthroscopic resection of a chondroblastoma in the knee. (7794436)
1995
27
MR of benign chondroblastoma of the temporal bone. (7726093)
1995
28
Chondroblastoma of the rib with widespread bone metastases. (7698736)
1994
29
Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. (1384228)
1992
30
Electron microscopic and immunohistochemical studies on chondroblastoma]. (1512479)
1992
31
Case report: metadiaphyseal chondroblastoma. (1737428)
1992
32
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
33
Chondroblastoma of bone. (2197612)
1990
34
Epidermal nevus syndrome: report of association with chondroblastoma of bone. (2616394)
1989
35
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
36
Chondroblastoma of the patella with a pathologic fracture. A case report. (3503985)
1987
37
Aggressive chondroblastoma of the femoral head. A case report. (3563736)
1987
38
Chondroblastoma of the sacrum. A case report. (3788507)
1986
39
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
40
Chondroblastoma of the rib. Report of a case. (4691660)
1973
41
Chondroblastoma--the nature of the basic cell. A study by means of histochemistry, tissue culture, electron microscopy, and autoradiography. (4260603)
1972
42
Benign chondroblastoma. A study of 125 cases. (5051664)
1972
43
Rare localization of chondroblastoma. (4258839)
1971
44
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
45
Benign chondroblastoma of tibia. (5507062)
1970
46
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
47
BENIGN CHONDROBLASTOMA OF MANDIBULAR CONDYLE: REPORT OF CASE. (14155482)
1964
48
Chondroblastoma. (14409207)
1959
49
Benign chondroblastoma of bone. (14895976)
1952
50
Benign chondroblastoma of bone; unusual localization in femoral capital epiphysis. (18136916)
1949

Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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Pathways related to Chondroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2SOX9, PTHLH

Compounds for genes affiliated with Chondroblastoma

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Compounds related to Chondroblastoma according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1isotretinoin45 1310.9CHKB, PTHLH
2phosphorus459.9CHKB, PTHLH
3bicarbonate459.9CHKB, PTHLH
4colchicine45 61 3 30 1313.9PTHLH, CHKB
5azathioprine45 3 51 1312.9CHKB, PTHLH
6lovastatin45 51 61 30 1313.8CHKB, PTHLH
7lead459.8CHKB, PTHLH
8guanidine hydrochloride459.8CHKB, SERPINA3
9prednisolone45 30 1311.8CHKB, PTHLH
10dihydrotestosterone45 30 26 1312.8PTHLH, CHKB
11urea45 26 1311.7CHKB, SERPINA3
12simvastatin45 51 61 30 26 1314.7CHKB, PTHLH
13endotoxin459.7PTHLH, CHKB
14glucose 6-phosphate45 2610.7HK2, CHKB
15ionomycin459.7SERPINA3, PTHLH
16valine459.7SERPINA3, PTHLH
17citrate459.6HK2, CHKB
18nacl459.5SERPINA3, CHKB
19polyacrylamide459.4CHKB, SERPINA3
20thyroxine45 2610.4PTHLH, SERPINA3, CHKB
21pyruvate459.4HK2, CHKB
22estradiol45 26 1311.4PTHLH, SERPINA3, CHKB
23heparin45 30 26 1312.4CHKB, SERPINA3, PTHLH
24arginine459.3CHKB, SERPINA3, PTHLH
25methotrexate51 45 1311.3CHKB, SERPINA3
26alanine459.3PTHLH, SERPINA3, CHKB
27glycogen45 2610.3HK2, CHKB, PTHLH
28lactate459.3PTHLH, CHKB, HK2
29estrogen459.3PTHLH, SERPINA3, CHKB
30threonine459.2HK2, SERPINA3, PTHLH
31agar459.2CHKB, PTHLH
32glyceraldehyde 3-phosphate459.2SOX9, HK2
33atp45 3010.1HK2, CHKB, PTHLH
34testosterone45 61 26 1312.1CHKB, SOX9, PTHLH
35zinc45 2610.0SERPINA3, SOX9, CHKB
36cyclic amp45 2610.0PTHLH, SOX9, HK2
37retinoic acid45 269.9PTHLH, SERPINA3, SOX9
38lipid458.9PTHLH, SERPINA3, HK2
39paraffin458.8PTHLH, SERPINA3, CHKB, HK2
40creatinine458.8HK2, CHKB, SERPINA3, PTHLH
41glucose458.8PTHLH, SERPINA3, CHKB, HK2
42steroid458.6PTHLH, SERPINA3, SOX9, CHKB
43dexamethasone45 51 30 1311.6CHKB, SOX9, SERPINA3, PTHLH
44vegf458.5HK2, CHKB, SOX9, PTHLH
45serine458.5HK2, SOX9, SERPINA3, PTHLH
46oxygen45 269.0HK2, CHKB, SOX9, SERPINA3, PTHLH

GO Terms for genes affiliated with Chondroblastoma

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Biological processes related to Chondroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00015019.2SOX9, PTHLH
2negative regulation of chondrocyte differentiationGO:00323318.9SOX9, PTHLH

Products for genes affiliated with Chondroblastoma

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Sources for Chondroblastoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet