MCID: CHN004
MIFTS: 39

Chondroblastoma malady

Bone category

Summaries for Chondroblastoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Chondroblastoma is a rare bone tumor, usually benign with a slow-growing nature. more...

MalaCards: Chondroblastoma, also known as chondroblastoma of bone, is related to papillary carcinoma and clear cell chondrosarcoma. An important gene associated with Chondroblastoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Endochondral Ossification and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include cortex, lung and thyroid.

Aliases & Classifications for Chondroblastoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

chondroblastoma 8 43 10 45 61
chondroblastoma of bone 8
chondroblastoma nos 8


External Ids:

Disease Ontology8 DOID:2649
MeSH35 D002804
NCIt40 C2945

Related Diseases for Chondroblastoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma29.9S100A2, S100A1, KRT7
2clear cell chondrosarcoma10.3
3bone giant cell tumor10.2
4synovitis10.1
5craniopharyngioma10.0KRT8
6stomach cancer10.0SERPINA3
7thymic carcinoma10.0KRT7
8gingivitis10.0TNFSF11
9synovial sarcoma10.0KRT7
10giant cell tumor10.0TNFSF11
11esophagitis10.0IL5
12hepatitis10.0KRT8
13sinusitis10.0IL5
14dysgerminoma10.0PTHLH, KRT7
15cholesteatoma10.0S100A1, TNFSF11
16sarcoma10.0KRT8, S100A1
17renal oncocytoma10.0S100A1, KRT7
18leiomyosarcoma10.0KRT8, S100A1
19diabetes mellitus10.0HK2
20dermatomyositis10.0SERPINA3, CHKB
21osteochondrodysplasia10.0PTHLH, SOX9
22myositis10.0SERPINA3, CHKB
23meningioma10.0S100A1
24osteoblastoma10.0ZNF133, TUBA1C
25nephrogenic adenoma10.0S100A1, KRT7
26cholangiocarcinoma10.0KRT8, KRT7
27ovarian cancer10.0KRT8, KRT7
28chordoma10.0KRT8, KRT7, S100A1
29myocardial infarction10.0S100A1, CHKB, SERPINA3
30chondrosarcoma10.0S100A1, SOX9, PTHLH, SERPINA3
31adenosquamous carcinoma10.0KRT7, KRT8, PTHLH
32epithelioid sarcoma10.0KRT7, KRT8
33abrikosov's tumor10.0S100A1, KRT7, KRT8
34pancreatic ductal carcinoma10.0KRT7, KRT8
35sarcoidosis10.0SERPINA3, KRT8
36oxyphilic adenoma10.0S100A1, KRT7, KRT8
37middle ear cholesteatoma10.0CHKB, TNFSF11
38cystic fibrosis10.0SERPINA3
39basal cell carcinoma10.0KRT8, KRT7, S100A2
40adenoid cystic carcinoma10.0SERPINA3, KRT8, KRT7, S100A1
41adenoameloblastoma10.0TNFSF11, KRT7, KRT8, SERPINA3
42hepatocellular carcinoma10.0TNFSF11, HK2, KRT7, KRT8
43arthritis10.0ADAMTS5, SERPINA3, TNFSF11
44osteoarthritis10.0S100A1, SOX9, TNFSF11, PTHLH, SERPINA3, ADAMTS5
45rheumatoid arthritis10.0S100A1, TNFSF11, CHKB, SERPINA3, ADAMTS5
46breast cancer10.0S100A1, HK2, KRT7, KRT8, PTHLH, SERPINA3
47psoriasis10.0SERPINA3, IL5, S100A1, S100A2
48prostate cancer10.0S100A2, TNFSF11, KRT7, KRT8, PTHLH, SERPINA3
49squamous cell carcinoma10.0S100A2, S100A1, HK2, KRT7, KRT8, PTHLH
50lung cancer10.0S100A2, S100A1, TNFSF11, HK2, KRT8, PTHLH

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Clinical Features for Chondroblastoma

Drugs & Therapeutics for Chondroblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chondroblastoma

Drug clinical trials:

Search ClinicalTrials for Chondroblastoma

Search NIH Clinical Center for Chondroblastoma

Search CenterWatch for Chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Chondroblastoma:

33
Cortex, Lung, Thyroid, T cells

Animal Models for Chondroblastoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Chondroblastoma

Sources:
51PubMed
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Articles related to Chondroblastoma:

(show top 50)    (show all 351)
idTitleAuthorsYear
1
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
2
Immunohistochemical analysis for Sox9 reveals the cartilaginous character of chondroblastoma and chondromyxoid fibroma of the bone. (19801163)
2010
3
Chondroblastoma of bone in a pediatric population. (19723993)
2009
4
Radiology corner. Answer to last month's radiology case and image: chondroblastoma with secondary aneurysmal bone cyst. (18333502)
2008
5
Chondroblastoma patella presenting as a pathological fracture. (19823666)
2008
6
Surgical management of skull base chondroblastoma. (17473681)
2007
7
Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. (16680777)
2006
8
Chondroblastoma with associated aneurysmal bone cyst of the cuboid. (15704086)
2005
9
Rotational acetabular osteotomy for benign chondroblastoma of the femoral head. A case report. (15930549)
2005
10
Chondroblastoma metastasis to lung visualized on bone scan. (15647679)
2005
11
Pathologic quiz case: right knee pain in a 29-year-old man. Chondroblastoma with aneurysmal bone cyst formation. (15628920)
2005
12
"Primary" aggressive chondroblastoma of the humerus: a case report. (15113430)
2004
13
Expression of cartilage growth plate signalling molecules in chondroblastoma. (14694528)
2004
14
Metastatic chondroblastoma with elevated creatine kinase and paraneoplastic neurologic autoimmunity. (14608202)
2003
15
Chondroblastoma of the talus: a case report. (12075906)
2002
16
Local recurrence of chondroblastoma. (11315800)
2001
17
Chondroblastoma of the thoracic vertebra. (11148083)
2001
18
Chondroblastoma of the lumbar vertebra. (11810169)
2001
19
Chondroblastoma-like osteosarcoma. (10192265)
1999
20
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
21
Temporal bone chondroblastoma. (10471886)
1999
22
Chondroblastoma in a metatarsal. (9470119)
1998
23
Malignant chondroblastoma of the os calcis. (18521232)
1998
24
Imprint cytology of chondroblastoma of bone. A case report. (9568146)
1998
25
Chondroblastoma of the patella with a secondary aneurysmal bone cyst. (9683708)
1998
26
Chondroblastoma--an unusual site in a young patient. (8759554)
1996
27
The use of the arthroscope as an adjunct in the resection of a chondroblastoma of the femoral head. (7727002)
1995
28
Chondroblastoma: classic and confusing appearance at MR imaging. (8284401)
1994
29
Chondroblastoma. (8464774)
1993
30
Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. (1384228)
1992
31
Human benign chondroblastoma with a pseudodiploid stemline characterized by a complex and balanced translocation. (1728944)
1992
32
Late pulmonary metastases from chondroblastoma of the distal femur. A case report. (2239176)
1990
33
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
34
Case report 467. Cystic chondroblastoma left 4th rib. (3363383)
1988
35
Histology and biology of metastatic chondroblastoma. Report of a case with a review of the literature. (3588400)
1987
36
Primary benign chondroblastoma cutis: extraskeletal manifestation without bone involvement. (3800417)
1987
37
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
38
A benign chondroblastoma with a rare location. (3160940)
1985
39
Benign Chondroblastoma. (7332302)
1981
40
Periosteal bone apposition in chondroblastoma. (515749)
1979
41
Benign chondroblastoma of bone. Report of a case. (1117026)
1975
42
Chondroblastoma--the nature of the basic cell. A study by means of histochemistry, tissue culture, electron microscopy, and autoradiography. (4260603)
1972
43
Chondroblastoma of bone. A clinicopathologic and electron microscopic study. (5060653)
1972
44
Benign chondroblastoma: report of four cases with a discussion of the presence of ossification. (4996902)
1971
45
Chondroblastoma of the skull. Case report. (5120010)
1971
46
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
47
Benign chondroblastoma. (5909069)
1966
48
Benign chondroblastoma of the pattella. A case report. (14040710)
1963
49
Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. (13284717)
1956
50
Benign chondroblastoma. (13331977)
1956

Genetic Variations for Chondroblastoma

Expression for genes affiliated with Chondroblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

Sources:
38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Chondroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SOX9, PTHLH, ADAMTS5
2
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.8TNFSF11, PTHLH, ADCY1
3
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.7TUBB2A, TUBA1C, ADCY1
49.6TUBB2A, TUBA1C, KRT7, KRT8

Compounds for genes affiliated with Chondroblastoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Chondroblastoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CHKB
2dexamethasone45 50 29 1113.4IL5, TNFSF11
3cycloheximide4510.4KRT8, SOX9
4urea45 11 2412.3TNFSF11, CHKB, KRT8
5phosphorus4510.3TNFSF11, CHKB, PTHLH
6bicarbonate4510.2TNFSF11, CHKB, PTHLH
7lonidamine45 6011.2HK2, ANO1
8b 7234510.2S100A1, KRT7, KRT8
9thyroxine45 2411.2CHKB, IL5, PTHLH, SERPINA3
10heparin45 29 11 2413.2TNFSF11, CHKB, SERPINA3, ADAMTS5
11salbutamol45 50 29 11 2414.2ADCY1, IL5, CHKB
12tartrate4510.2PTHLH, TNFSF11
13colchicine60 45 2 29 1114.1TUBB2A, TUBA1C, CHKB, PTHLH
14agar4510.1PTHLH, KRT8, IL5, CHKB
15hematoxylin4510.1S100A1, KRT7, KRT8
16theophylline45 29 11 2413.1ADCY1, IL5, CHKB
17olopatadine45 1111.1S100A1, S100A2
18ionomycin4510.0IL5, PTHLH, SERPINA3, ADCY1
19methotrexate45 50 1112.0TNFSF11, CHKB, IL5, KRT7, SERPINA3
20azathioprine45 50 2 1112.9TNFSF11, CHKB, PTHLH
21vitamin d459.9TNFSF11, CHKB, IL5, PTHLH
22steroid459.9SOX9, TNFSF11, CHKB, KRT8, PTHLH, SERPINA3
23glycogen45 2410.8S100A1, CHKB, HK2, KRT7, KRT8, PTHLH
24cyclic amp45 2410.8SOX9, TNFSF11, HK2, PTHLH, ADCY1
25oxygen45 2410.7SOX9, TNFSF11, CHKB, HK2, PTHLH, SERPINA3
26testosterone45 60 11 2412.7SOX9, TNFSF11, CHKB, IL5, KRT7, KRT8
27zinc45 2410.6S100A2, S100A1, SOX9, TNFSF11, CHKB, SERPINA3
28creatinine459.6TNFSF11, CHKB, HK2, KRT8, PTHLH, SERPINA3
29progesterone45 60 29 11 2413.6S100A1, KRT7, KRT8, PTHLH, SERPINA3, ADCY1
30cysteine459.6S100A2, S100A1, TNFSF11, CHKB, IL5, KRT8
31arginine459.6CHKB, IL5, KRT7, PTHLH, SERPINA3, ADCY1
32glucose459.5CHKB, HK2, KRT7, KRT8, PTHLH, SERPINA3
33vegf459.5SOX9, TNFSF11, CHKB, HK2, IL5, KRT7
34atp45 2910.4TNFSF11, ATP5B, CHKB, HK2, KRT8, PTHLH
35retinoic acid45 2410.4S100A1, SOX9, IL5, KRT7, KRT8, PTHLH
36serine459.4SERPINA3, KRT8, HK2, TNFSF11, SOX9
37paraffin459.3SERPINA3, S100A1, TNFSF11, CHKB, HK2, IL5
38calcium45 50 11 2412.0S100A2, S100A1, TNFSF11, CHKB, ANO1, KRT8

GO Terms for genes affiliated with Chondroblastoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Chondroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of chondrocyte differentiationGO:03233110.2PTHLH, SOX9

Molecular functions related to Chondroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.7ADAMTS5, S100A1, SOX9, USP6, ATP5B, ANO1

Products for genes affiliated with Chondroblastoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Chondroblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet