MCID: CHN004
MIFTS: 41

Chondroblastoma malady

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

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Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 11 46 13 48 37 66
 
Chondroblastoma of Bone 11

Classifications:



External Ids:

Disease Ontology11 DOID:2649
MeSH37 D002804
NCIt43 C2945

Summaries for Chondroblastoma

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Wikipedia:69 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to hydranencephaly and hemorrhagic shock and encephalopathy syndrome, and has symptoms including pain An important gene associated with Chondroblastoma is SOX9 (SRY-Box 9), and among its related pathways are Osteoblast Signaling and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are no phenotypic analysis and reproductive system.

Related Diseases for Chondroblastoma

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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1hydranencephaly10.5CXCL8, TNFSF11
2hemorrhagic shock and encephalopathy syndrome10.5PTGS2, TNFSF11
3blastomycosis10.5PTH1R, TNFSF11
4impotence10.5PTH1R, TNFSF11
5rasmussen subacute encephalitis10.5CXCL8, PTGS2
6aneurysm10.4
7aneurysmal bone cysts10.4
8tarsal tunnel syndrome10.4CXCL8, IL5
9acute interstitial pneumonia10.4CXCL8, IL5
10orbital plasma cell granuloma10.4CXCL8, IL5
11skin disease10.3CXCL8, IL5
12antidepressant or antipsychotic toxicity or dose selection10.3PTGS2, TNFSF11
13acquired hyperkeratosis10.3PTH1R, TNFSF11
14hidradenitis suppurativa10.3CXCL8, PTGS2
15basidiobolomycosis10.3CXCL8, IL4
16mild phosphoribosylpyrophosphate synthetase superactivity10.3PTH1R, SOX9
17anterior dislocation of lens10.3CXCL8, IL4
18retinal vascular disease10.3CXCL8, IL4
19plantar wart10.2CXCL8, IL4
20fibroma10.2
21chondromyxoid fibroma10.2
22tibialis tendinitis10.2CXCL8, PTGS2
23orbital lymphangioma10.2CXCL8, IL4
24intracortical osteogenic sarcoma10.2CXCL8, PTGS2
25keratoconjunctivitis10.2IL4, IL5
26chronic pulmonary heart disease10.2IL4, IL5
27pediatric germ cell cancer10.2IL5, PTGS2
28papillary squamous carcinoma10.2IL4, IL5
29myositis fibrosa10.2IL4, IL5
30vibrio vulnificus infection10.2IL4, IL5
31chondrosarcoma10.2
32gonococcal synovitis10.2IL4, IL5
33epididymis adenocarcinoma10.1IL4, IL5
34malignant giant cell tumor10.1CXCL8, PTGS2, TNFSF11
35glucose intolerance10.1IL4, IL5
36purpura fulminans10.1IL4, IL5
37acute gonococcal salpingitis10.1IL4, IL5
38bacterial gastritis10.1IL4, IL5
39apple allergy10.1IL4, IL5
40cervix melanoma10.1IL4, IL5
41central nervous system origin vertigo10.1IL4, IL5
42pituitary hypoplasia10.1IL4, IL5
43shwartzman phenomenon10.1CXCL8, IL2
44adenomatoid tumor10.1IL4, IL5
45maligant granulosa cell tumor of ovary10.1CXCL8, IL2
46african histoplasmosis10.1IL4, IL5
47spermatic cord cancer10.1IL4, IL5
48fallopian tube disease10.1CXCL8, IL2
49multiple system atrophy, cerebellar type10.1IL4, IL5
50addison's disease10.1CXCL8, IL2

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms for Chondroblastoma

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UMLS symptoms related to Chondroblastoma:


pain

Drugs & Therapeutics for Chondroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chondroblastoma


Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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MalaCards organs/tissues related to Chondroblastoma:

34
Bone, Lung, Testes, Thyroid, Cortex

Animal Models for Chondroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Chondroblastoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030127.9IL2, IL4, PTGS2, SOX9, TNFSF11
2MP:00053897.5IL2, IL4, IL5, PTGS2, SOX9, TNFSF11
3MP:00053817.1IL2, IL4, IL5, PTGS2, PTH1R, SOX9
4MP:00053887.1IL2, IL4, IL5, PTGS2, PTH1R, SOX9
5MP:00053786.6HK2, IL2, IL4, IL5, PTGS2, PTH1R

Publications for Chondroblastoma

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Articles related to Chondroblastoma:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. (27299121)
2016
2
Epigenetics: Histone mutations reprogramme chondroblastoma. (27339705)
2016
3
Chondroblastoma of bone in the extremities: a multicenter retrospective study. (26041854)
2015
4
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. (27408892)
2015
5
Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. (25432292)
2015
6
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
7
What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? (25115583)
2014
8
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
9
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
10
Peculiar chondroblastoma involving multiple tarsal bones. (20383766)
2010
11
Recurrent and aggressive chondroblastoma: a case report. (18306552)
2007
12
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
13
Aggressive scapular chondroblastoma with secondary metastasis--a case report and review of literature. (16751114)
2006
14
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
15
Chondroblastoma of the hands and feet. (15316680)
2004
16
Tetraparesis caused by chondroblastoma of the cervical spine: a case report. (12942021)
2003
17
Chondroblastoma of the thoracic vertebra. (11148083)
2001
18
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
19
Chondroblastoma of the temporal bone: consistent middle fossa involvement. (17171120)
1999
20
Chondroblastoma of the temporomandibular joint: case report with cytopathologic and histopathologic study. (10555806)
1999
21
Malignant chondroblastoma of the os calcis. (18521232)
1998
22
MR of benign chondroblastoma of the temporal bone. (7726093)
1995
23
Actin-positive chondroblasts (myochondroblasts) in benign chondroblastoma. (9444786)
1995
24
Chondroblastoma of the acromion. (7610418)
1995
25
Chondroblastoma of the rib with widespread bone metastases. (7698736)
1994
26
Temporal bone chondroblastoma: big and small. (7861099)
1994
27
Chondroblastoma of the temporal bone: CT and MR appearance. (8427113)
1993
28
Case report: metadiaphyseal chondroblastoma. (1737428)
1992
29
Case report 663. Unusual chondroblastoma of the scapula. (2057799)
1991
30
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
31
Surgical management of chondroblastoma of the temporal bone. (2108415)
1990
32
Test and teach. Number Sixty-two. Chondroblastoma of the scaphoid. (2362777)
1990
33
Epidermal nevus syndrome: report of association with chondroblastoma of bone. (2616394)
1989
34
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
35
Chondroblastoma of the patella with a pathologic fracture. A case report. (3503985)
1987
36
Aggressive chondroblastoma of the femoral head. A case report. (3563736)
1987
37
Chondroblastoma: a clinical and radiological study of 104 cases. (4023729)
1985
38
Aggressive chondroblastoma. Report of a case with multiple bone and soft tissue involvement. (598129)
1977
39
Metaphyseal chondroblastoma of bone. (970548)
1976
40
Chondroblastoma of the cervical spine. Case report. (4710657)
1973
41
Rare localization of chondroblastoma. (4258839)
1971
42
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
43
Benign chondroblastoma: report of four cases with a discussion of the presence of ossification. (4996902)
1971
44
Benign chondroblastoma of tibia. (5507062)
1970
45
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
46
BENIGN CHONDROBLASTOMA OF MANDIBULAR CONDYLE: REPORT OF CASE. (14155482)
1964
47
Benign chondroblastoma of the pattella. A case report. (14040710)
1963
48
Chondroblastoma. (14409207)
1959
49
Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. (13284717)
1956
50
Benign chondroblastoma of bone; unusual localization in femoral capital epiphysis. (18136916)
1949

Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.8PTH1R, TNFSF11
29.8PTH1R, TNFSF11
39.1CXCL8, PTGS2, TNFSF11
49.0IL4, IL5
59.0CXCL8, IL2, PTGS2
6
Show member pathways
8.5IL2, IL4, IL5
78.5IL2, IL4, IL5
88.5IL2, IL4, IL5
98.5IL2, IL4, IL5
108.5IL2, IL4, IL5
118.5IL2, IL4, IL5
128.5IL2, IL4, IL5
138.4CXCL8, IL2, IL4, SOX9
148.2IL2, IL4, PTGS2, TNFSF11
158.1CXCL8, IL2, IL4, IL5
16
Show member pathways
8.1CXCL8, IL2, IL4, IL5
17
Show member pathways
8.1CXCL8, IL2, IL4, IL5
18
Show member pathways
7.7CXCL8, IL2, IL4, IL5, TNFSF11
197.7CXCL8, IL2, IL4, IL5, TNFSF11
20
Show member pathways
7.5CXCL8, IL2, IL4, IL5, PTGS2
21
Show member pathways
7.2CXCL8, IL2, IL4, IL5, PTGS2, TNFSF11
22
Show member pathways
6.9CXCL8, IL2, IL4, IL5, PTGS2, SOX9

GO Terms for genes affiliated with Chondroblastoma

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Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.7CXCL8, IL2, IL4, IL5, TNFSF11

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.3SOX9, TNFSF11
2chondrocyte differentiationGO:000206210.3PTH1R, SOX9
3bone resorptionGO:004545310.2PTH1R, TNFSF11
4positive regulation of immunoglobulin secretionGO:005102410.0IL2, IL5
5bone mineralizationGO:00302829.9PTGS2, PTH1R
6positive regulation of activated T cell proliferationGO:00421049.7IL2, IL4
7positive regulation of isotype switching to IgG isotypesGO:00483049.7IL2, IL4
8positive regulation of T cell differentiationGO:00455829.7IL2, IL4
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.6IL2, IL4
10ossificationGO:00015039.6PTH1R, SOX9, TNFSF11
11extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.6IL2, IL4
12positive regulation of protein phosphorylationGO:00019349.3IL2, IL4, SOX9
13positive regulation of B cell proliferationGO:00308909.1IL2, IL4, IL5
14positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.0IL4, IL5, TNFSF11
15negative regulation of cell proliferationGO:00082858.6CXCL8, PTGS2, PTH1R, SOX9
16immune responseGO:00069557.6CXCL8, IL2, IL4, IL5, TNFSF11
17positive regulation of cell proliferationGO:00082847.4IL2, IL4, IL5, PTGS2, PTH1R, SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.5IL2, IL4, IL5
2cytokine activityGO:00051257.8IL2, IL4, IL5, TNFSF11

Sources for Chondroblastoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet