MCID: CHN004
MIFTS: 43

Chondroblastoma malady

Bone diseases category

Summaries for Chondroblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chondroblastoma is a rare bone tumor, usually benign with a slow-growing nature. more...

MalaCards: Chondroblastoma, also known as chondroblastoma of bone, is related to chondrosarcoma and giant cell tumor. An important gene associated with Chondroblastoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Endochondral Ossification and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes.

Aliases & Classifications for Chondroblastoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

chondroblastoma 8 42 10 44 60
chondroblastoma of bone 8
chondroblastoma nos 8


External Ids:

Disease Ontology8 DOID:2649
MeSH34 D002804
NCIt39 C2945

Related Diseases for Chondroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.4S100A1, SOX9, PTHLH, SERPINA3
2giant cell tumor30.3TNFSF11
3sarcoma29.8KRT8, S100A1
4meningioma29.8S100A1
5papillary carcinoma29.8S100A2, S100A1, KRT7
6clear cell chondrosarcoma10.2
7osteosarcoma10.2
8bone giant cell tumor10.2
9cervicitis10.1
10chondroma10.1
11periostitis10.1
12synovitis10.1
13craniopharyngioma10.0KRT8
14stomach cancer10.0SERPINA3
15thymus cancer10.0KRT7
16gingivitis10.0TNFSF11
17synovial sarcoma10.0KRT7
18esophagitis10.0IL5
19hepatitis10.0KRT8
20sinusitis10.0IL5
21dysgerminoma10.0PTHLH, KRT7
22cholesteatoma10.0S100A1, TNFSF11
23renal oncocytoma10.0S100A1, KRT7
24leiomyosarcoma10.0KRT8, S100A1
25diabetes mellitus10.0HK2
26dermatomyositis10.0SERPINA3, CHKB
27osteochondrodysplasia10.0PTHLH, SOX9
28myositis10.0SERPINA3, CHKB
29osteoblastoma10.0ZNF133, TUBA1C
30nephrogenic adenoma10.0S100A1, KRT7
31cholangiocarcinoma10.0KRT8, KRT7
32ovarian cancer10.0KRT8, KRT7
33chordoma10.0KRT8, KRT7, S100A1
34myocardial infarction10.0S100A1, CHKB, SERPINA3
35adenosquamous carcinoma10.0KRT7, KRT8, PTHLH
36epithelioid sarcoma10.0KRT7, KRT8
37abrikosov's tumor10.0S100A1, KRT7, KRT8
38pancreatic ductal carcinoma10.0KRT7, KRT8
39sarcoidosis10.0SERPINA3, KRT8
40oxyphilic adenoma10.0S100A1, KRT7, KRT8
41middle ear cholesteatoma10.0CHKB, TNFSF11
42cystic fibrosis10.0SERPINA3
43basal cell carcinoma10.0KRT8, KRT7, S100A2
44adenoid cystic carcinoma10.0SERPINA3, KRT8, KRT7, S100A1
45adenoameloblastoma10.0TNFSF11, KRT7, KRT8, SERPINA3
46hepatocellular carcinoma10.0TNFSF11, HK2, KRT7, KRT8
47arthritis10.0ADAMTS5, SERPINA3, TNFSF11
48osteoarthritis10.0S100A1, SOX9, TNFSF11, PTHLH, SERPINA3, ADAMTS5
49rheumatoid arthritis10.0S100A1, TNFSF11, CHKB, SERPINA3, ADAMTS5
50breast cancer10.0S100A1, HK2, KRT7, KRT8, PTHLH, SERPINA3

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Clinical Features for Chondroblastoma

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Drugs & Therapeutics for Chondroblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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32MalaCards
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MalaCards organs/tissues related to Chondroblastoma:

32
Bone, Lung, Testes, Thyroid, Cortex

Animal Models for Chondroblastoma or affiliated genes

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Publications for Chondroblastoma

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50PubMed
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Articles related to Chondroblastoma:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
A guise of osteosarcoma: Chondroblastoma-like. (24355968)
2013
2
Secondary aneurysmal bone cyst following chondroblastoma of the patella. (24179655)
2013
3
Chondroblastoma in a metatarsal treated with autogenous fibular graft: a case report. (22297106)
2012
4
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
5
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
6
Chondroblastoma: a rare cause of femoral neck fracture in a teenager. (22022682)
2011
7
Chondroblastoma of the fourth lumbar vertebra diagnosed by aspiration biopsy: case report and review of the literature. (21986177)
2011
8
Radiologic case study. Chondroblastoma with geographic bone destruction and a sclerotic rim. (19681548)
2009
9
A case of locally advanced chondroblastoma in the proximal humerus. (19103672)
2009
10
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
11
Diaphyseal chondroblastoma in a long bone: first report. (16010594)
2006
12
Giant chondroblastoma of the scapula with pulmonary metastases. (16007463)
2006
13
Metastatic chondroblastoma with elevated creatine kinase and paraneoplastic neurologic autoimmunity. (14608202)
2003
14
Tetraparesis caused by chondroblastoma of the cervical spine: a case report. (12942021)
2003
15
Results of curettage and high-speed burring for chondroblastoma of the bone. (14717211)
2003
16
Radiologic case study. Benign cartilaginous neoplasm; chondroblastoma. (12755208)
2003
17
Chondroblastoma of a metacarpal bone mimicking an aneurysmal bone cyst: a case report and a review of the literature. (11725841)
2001
18
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
19
Chondroblastoma in a metatarsal. (9470119)
1998
20
Chondroblastoma of the foot. (9127115)
1997
21
Inflammatory reaction in chondroblastoma. (8738003)
1996
22
Fine needle aspiration cytology of chondroblastoma and chondromyxoid fibroma. A report of two cases. (8042429)
1994
23
Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. (1384228)
1992
24
Case report 748: Chondroblastoma of the femur with an aneurysmal bone cyst. (1523439)
1992
25
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
26
Chondroblastoma of bone. (2197612)
1990
27
Case report 537. Chondroblastoma. (2749291)
1989
28
Chondroblastoma of the talus: natural development over 9.5 years. Case report. (3358668)
1988
29
Histology and biology of metastatic chondroblastoma. Report of a case with a review of the literature. (3588400)
1987
30
About one case of vertebral chondroblastoma. (3627860)
1987
31
Chondroblastoma of the skull and facial bones. (3604981)
1987
32
Chondroblastoma--two contrasting presentations. (3653964)
1987
33
Rare forms of chondroblastoma. Cystic and diaphyseal types. (3610613)
1986
34
Chondroblastoma of a metacarpal. Report of a case and review of the literature. (3884206)
1985
35
Benign chondroblastoma of the temporal bone. (503493)
1979
36
Metastatic chondroblastoma: report of an unusual case treated with radiotherapy. (455268)
1979
37
Chondroblastoma of the calcaneus: radiographic features with emphasis on location. (403790)
1977
38
An unusual case of cystic chondroblastoma of the patella. (991501)
1976
39
Chondroblastoma of bone. A critical review. (4585180)
1973
40
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
41
Benign chondroblastoma of rib. (5089674)
1971
42
Chondroblastoma of bone. (5263146)
1970
43
Quantitative microchemical studies of chondroblastoma, giant-cell tumor, chondromyxoid fibroma and desmoplastic fibroma. (4315212)
1970
44
AN UNUSUAL CHONDROBLASTOMA. (14131433)
1964
45
Chondroblastoma of the cuboid. Case report. (14434165)
1960
46
Chondroblastoma (Codman's tumour) of the thoracic spine. (13491633)
1957
47
Chondroblastoma of the talus: a case report. (13356528)
1956
48
Benign chondroblastoma of bone; an unusual localization in temporal bone. (14375495)
1955
49
Benign chondroblastoma (Codman's tumor); case report and review of literature. (14348766)
1955
50
Epiphyseal chondroblastoma of bone. (14880556)
1951

Genetic Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Chondroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ADAMTS5, PTHLH, SOX9
2
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.8TNFSF11, PTHLH, ADCY1
3
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.7ADCY1, TUBA1C, TUBB2A
49.6KRT8, KRT7, TUBA1C, TUBB2A

Compounds for genes affiliated with Chondroblastoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Chondroblastoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHKB
2dexamethasone44 49 28 1113.4IL5, TNFSF11
3cycloheximide4410.4KRT8, SOX9
4urea44 11 2412.3TNFSF11, CHKB, KRT8
5phosphorus4410.3TNFSF11, CHKB, PTHLH
6bicarbonate4410.2TNFSF11, CHKB, PTHLH
7lonidamine44 5911.2HK2, ANO1
8b 7234410.2S100A1, KRT7, KRT8
9thyroxine44 2411.2CHKB, IL5, PTHLH, SERPINA3
10heparin44 28 11 2413.2TNFSF11, CHKB, SERPINA3, ADAMTS5
11salbutamol44 49 28 11 2414.2ADCY1, IL5, CHKB
12tartrate4410.2PTHLH, TNFSF11
13colchicine59 44 2 28 1114.1TUBB2A, TUBA1C, CHKB, PTHLH
14agar4410.1PTHLH, KRT8, IL5, CHKB
15hematoxylin4410.1S100A1, KRT7, KRT8
16theophylline44 28 11 2413.1ADCY1, IL5, CHKB
17olopatadine44 1111.1S100A1, S100A2
18ionomycin4410.0IL5, PTHLH, SERPINA3, ADCY1
19methotrexate44 49 1112.0TNFSF11, CHKB, IL5, KRT7, SERPINA3
20azathioprine44 49 2 1112.9TNFSF11, CHKB, PTHLH
21vitamin d449.9TNFSF11, CHKB, IL5, PTHLH
22steroid449.9SOX9, TNFSF11, CHKB, KRT8, PTHLH, SERPINA3
23glycogen44 2410.8S100A1, CHKB, HK2, KRT7, KRT8, PTHLH
24cyclic amp44 2410.8SOX9, TNFSF11, HK2, PTHLH, ADCY1
25oxygen44 2410.7SOX9, TNFSF11, CHKB, HK2, PTHLH, SERPINA3
26testosterone44 59 11 2412.7SOX9, TNFSF11, CHKB, IL5, KRT7, KRT8
27zinc44 2410.6S100A2, S100A1, SOX9, TNFSF11, CHKB, SERPINA3
28creatinine449.6TNFSF11, CHKB, HK2, KRT8, PTHLH, SERPINA3
29progesterone44 59 28 11 2413.6S100A1, KRT7, KRT8, PTHLH, SERPINA3, ADCY1
30cysteine449.6S100A2, S100A1, TNFSF11, CHKB, IL5, KRT8
31arginine449.6CHKB, IL5, KRT7, PTHLH, SERPINA3, ADCY1
32glucose449.5CHKB, HK2, KRT7, KRT8, PTHLH, SERPINA3
33vegf449.5SOX9, TNFSF11, CHKB, HK2, IL5, KRT7
34atp44 2810.4TNFSF11, ATP5B, CHKB, HK2, KRT8, PTHLH
35retinoic acid44 2410.4S100A1, SOX9, IL5, KRT7, KRT8, PTHLH
36serine449.4SERPINA3, KRT8, HK2, TNFSF11, SOX9
37paraffin449.3SERPINA3, S100A1, TNFSF11, CHKB, HK2, IL5
38calcium44 49 11 2412.0S100A2, S100A1, TNFSF11, CHKB, ANO1, KRT8

GO Terms for genes affiliated with Chondroblastoma

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16Gene Ontology
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Biological processes related to Chondroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of chondrocyte differentiationGO:03233110.2PTHLH, SOX9

Molecular functions related to Chondroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.7ADAMTS5, S100A1, SOX9, USP6, ATP5B, ANO1

Products for genes affiliated with Chondroblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chondroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet