MCID: CHN004
MIFTS: 40

Chondroblastoma malady

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

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Aliases & Descriptions for Chondroblastoma:

Name: Chondroblastoma 11 47 49 38 13 67
 
Chondroblastoma of Bone 11

Classifications:



External Ids:

Disease Ontology11 DOID:2649
MeSH38 D002804
NCIt44 C2945

Summaries for Chondroblastoma

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Wikipedia:70 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

MalaCards based summary: Chondroblastoma, also known as chondroblastoma of bone, is related to blastoma and blastomycosis, and has symptoms including pain An important gene associated with Chondroblastoma is SOX9 (SRY-Box 9), and among its related pathways are Osteoblast Signaling and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Related Diseases for Chondroblastoma

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Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1blastoma10.8
2blastomycosis10.5PTH1R, TNFSF11
3impotence10.5PTH1R, TNFSF11
4mild phosphoribosylpyrophosphate synthetase superactivity10.4PTH1R, SOX9
5acquired hyperkeratosis10.4PTH1R, TNFSF11
6syphilitic myelopathy10.4FGFR1, SOX9
7aneurysm10.3
8aneurysmal bone cysts10.3
9small cell neuroendocrine carcinoma10.3PTH1R, SOX9
10nail disorder, nonsyndromic congenital, 110.3FGFR1, TNFSF11
11hemorrhagic shock and encephalopathy syndrome10.3PTGS2, TNFSF11
12hypochondroplasia10.2FGFR1, PTH1R, SOX9
13keratoconjunctivitis10.2IL4, IL5
14chronic pulmonary heart disease10.2IL4, IL5
15papillary squamous carcinoma10.2IL4, IL5
16myositis fibrosa10.2IL4, IL5
17vibrio vulnificus infection10.2IL4, IL5
18thomsen and becker disease10.2IL4, IL5
19gonococcal synovitis10.2IL4, IL5
20dioctophymiasis10.2IL4, IL5
21epididymis adenocarcinoma10.2IL4, IL5
22glucose intolerance10.2IL4, IL5
23purpura fulminans10.2IL4, IL5
24acute gonococcal salpingitis10.2IL4, IL5
25bacterial gastritis10.2IL4, IL5
26apple allergy10.2IL4, IL5
27cervix melanoma10.2IL4, IL5
28central nervous system origin vertigo10.2IL4, IL5
29pituitary hypoplasia10.2IL4, IL5
30adenomatoid tumor10.1IL4, IL5
31african histoplasmosis10.1IL4, IL5
32spermatic cord cancer10.1IL4, IL5
33multiple system atrophy, cerebellar type10.1IL4, IL5
34peanut allergy10.1IL4, IL5
35orbital periostitis10.1IL4, TNFSF11
36antidepressant or antipsychotic toxicity or dose selection10.1PTGS2, TNFSF11
37philophthalmiasis10.1IL4, IL5
38dacryoadenitis10.1IL4, IL5
39fibroma10.1
40chondromyxoid fibroma10.1
41gait apraxia10.1IL4, IL5
42hydranencephaly10.1CXCL8, TNFSF11
43gonococcal keratitis10.1IL4, IL5
44melanoacanthoma10.0IL4, IL5
45chondrosarcoma10.0
46tetanus neonatorum10.0IL4, IL5
47pediatric germ cell cancer10.0IL5, PTGS2
48tarsal tunnel syndrome10.0CXCL8, IL5
49basidiobolomycosis10.0CXCL8, IL4
50acute conjunctivitis10.0CA10, IL4, IL5

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to chondroblastoma

Symptoms for Chondroblastoma

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UMLS symptoms related to Chondroblastoma:


pain

Drugs & Therapeutics for Chondroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chondroblastoma


Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

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Anatomical Context for Chondroblastoma

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MalaCards organs/tissues related to Chondroblastoma:

35
Bone, Lung, Testes, Thyroid, Cortex

Animal Models for Chondroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Chondroblastoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.3FGFR1, IL4, PTH1R, SOX9, TNFSF11
2MP:00030129.0FGFR1, IL4, PTGS2, SOX9, TNFSF11
3MP:00053808.7FGFR1, HK2, IL5, PTGS2, PTH1R, SOX9
4MP:00028738.6FGFR1, HK2, IL4, PTGS2, SOX9, TNFSF11
5MP:00053818.6FGFR1, IL4, IL5, PTGS2, PTH1R, SOX9
6MP:00053888.6IL4, IL5, PTGS2, PTH1R, SOX9, TNFSF11
7MP:00053898.4FGFR1, IL4, IL5, PTGS2, SOX9, TNFSF11
8MP:00053907.9FGFR1, IL4, PTGS2, PTH1R, SOX9, TNFSF11
9MP:00053787.8FGFR1, HK2, IL4, IL5, PTGS2, PTH1R

Publications for Chondroblastoma

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Articles related to Chondroblastoma:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. (27299121)
2016
2
Epigenetics: Histone mutations reprogramme chondroblastoma. (27339705)
2016
3
Chondroblastoma of bone in the extremities: a multicenter retrospective study. (26041854)
2015
4
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. (27408892)
2015
5
Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. (25432292)
2015
6
Meningothelial meningioma with chondroblastoma-like and granuloma-like nodules. (24849285)
2014
7
What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head? (25115583)
2014
8
Clinical and radiological long-term results after operative treatment of chondroblastoma. (20364261)
2011
9
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
10
Peculiar chondroblastoma involving multiple tarsal bones. (20383766)
2010
11
Recurrent and aggressive chondroblastoma: a case report. (18306552)
2007
12
False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression. (16333655)
2006
13
Aggressive scapular chondroblastoma with secondary metastasis--a case report and review of literature. (16751114)
2006
14
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
15
Chondroblastoma of the hands and feet. (15316680)
2004
16
Tetraparesis caused by chondroblastoma of the cervical spine: a case report. (12942021)
2003
17
Chondroblastoma of the thoracic vertebra. (11148083)
2001
18
Cutaneous metastases from a chondroblastoma initially presenting as unilateral palmar hyperhidrosis. (10025860)
1999
19
Chondroblastoma of the temporal bone: consistent middle fossa involvement. (17171120)
1999
20
Chondroblastoma of the temporomandibular joint: case report with cytopathologic and histopathologic study. (10555806)
1999
21
Malignant chondroblastoma of the os calcis. (18521232)
1998
22
MR of benign chondroblastoma of the temporal bone. (7726093)
1995
23
Actin-positive chondroblasts (myochondroblasts) in benign chondroblastoma. (9444786)
1995
24
Chondroblastoma of the acromion. (7610418)
1995
25
Chondroblastoma of the rib with widespread bone metastases. (7698736)
1994
26
Temporal bone chondroblastoma: big and small. (7861099)
1994
27
Chondroblastoma of the temporal bone: CT and MR appearance. (8427113)
1993
28
Case report: metadiaphyseal chondroblastoma. (1737428)
1992
29
Case report 663. Unusual chondroblastoma of the scapula. (2057799)
1991
30
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
31
Surgical management of chondroblastoma of the temporal bone. (2108415)
1990
32
Test and teach. Number Sixty-two. Chondroblastoma of the scaphoid. (2362777)
1990
33
Epidermal nevus syndrome: report of association with chondroblastoma of bone. (2616394)
1989
34
Case report 449: Chondroblastoma involving C5 and C6. (3358136)
1988
35
Chondroblastoma of the patella with a pathologic fracture. A case report. (3503985)
1987
36
Aggressive chondroblastoma of the femoral head. A case report. (3563736)
1987
37
Chondroblastoma: a clinical and radiological study of 104 cases. (4023729)
1985
38
Aggressive chondroblastoma. Report of a case with multiple bone and soft tissue involvement. (598129)
1977
39
Metaphyseal chondroblastoma of bone. (970548)
1976
40
Chondroblastoma of the cervical spine. Case report. (4710657)
1973
41
Rare localization of chondroblastoma. (4258839)
1971
42
Benign chondroblastoma with soft-tissue recurrence. (5287075)
1971
43
Benign chondroblastoma: report of four cases with a discussion of the presence of ossification. (4996902)
1971
44
Benign chondroblastoma of tibia. (5507062)
1970
45
Congenital atypical benign chondroblastoma of a rib. (4314040)
1970
46
BENIGN CHONDROBLASTOMA OF MANDIBULAR CONDYLE: REPORT OF CASE. (14155482)
1964
47
Benign chondroblastoma of the pattella. A case report. (14040710)
1963
48
Chondroblastoma. (14409207)
1959
49
Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. (13284717)
1956
50
Benign chondroblastoma of bone; unusual localization in femoral capital epiphysis. (18136916)
1949

Variations for Chondroblastoma

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Expression for genes affiliated with Chondroblastoma

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Search GEO for disease gene expression data for Chondroblastoma.

Pathways for genes affiliated with Chondroblastoma

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Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.8PTH1R, TNFSF11
29.8PTH1R, TNFSF11
39.4IL4, IL5
49.4IL4, IL5
59.4IL4, IL5
69.4IL4, IL5
79.4FGFR1, PTH1R, SOX9
89.0CXCL8, PTGS2
98.8CXCL8, IL4, SOX9
108.7CXCL8, PTGS2, TNFSF11
11
Show member pathways
8.6CXCL8, IL4, IL5
128.6CXCL8, IL4, IL5
138.2CXCL8, IL4, IL5, TNFSF11
14
Show member pathways
8.2CXCL8, FGFR1, IL4, IL5
15
Show member pathways
8.0CXCL8, IL4, IL5, PTGS2
16
Show member pathways
7.8CXCL8, FGFR1, IL4, IL5, TNFSF11
17
Show member pathways
7.8CXCL8, FGFR1, IL4, IL5, TNFSF11
18
Show member pathways
7.2CXCL8, FGFR1, IL4, IL5, PTGS2, TNFSF11
19
Show member pathways
6.9CXCL8, FGFR1, IL4, IL5, PTGS2, SOX9

GO Terms for genes affiliated with Chondroblastoma

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Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1ERK1 and ERK2 cascadeGO:007037110.3SOX9, TNFSF11
2bone resorptionGO:004545310.2PTH1R, TNFSF11
3positive regulation of mesenchymal cell proliferationGO:000205310.2FGFR1, SOX9
4cell maturationGO:004846910.2FGFR1, PTH1R
5bone mineralizationGO:003028210.0PTGS2, PTH1R
6positive regulation of B cell proliferationGO:003089010.0IL4, IL5
7chondrocyte differentiationGO:00020629.9FGFR1, PTH1R, SOX9
8ossificationGO:00015039.8PTH1R, SOX9, TNFSF11
9skeletal system developmentGO:00015019.7FGFR1, PTH1R, SOX9
10positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL4, IL5, TNFSF11
11regulation of cell proliferationGO:00421279.2FGFR1, PTGS2, SOX9
12angiogenesisGO:00015258.8CXCL8, FGFR1, PTGS2
13immune responseGO:00069558.4CXCL8, IL4, IL5, TNFSF11
14negative regulation of cell proliferationGO:00082858.1CXCL8, PTGS2, PTH1R, SOX9
15positive regulation of cell proliferationGO:00082847.7FGFR1, IL4, IL5, PTGS2, PTH1R, SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL4, IL5, TNFSF11

Sources for Chondroblastoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet