MCID: CHN059
MIFTS: 37

Chondrocalcinosis malady

Categories: Genetic diseases, Bone diseases, Rare diseases

Aliases & Classifications for Chondrocalcinosis

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Aliases & Descriptions for Chondrocalcinosis:

Name: Chondrocalcinosis 10 47 12 36
Pseudogout 10 47 65
 
Calcium Pyrophosphate Deposition Disease 10 65

Classifications:



External Ids:

Disease Ontology10 DOID:1156
ICD9CM29 712.1
MeSH36 D002805
NCIt42 C34955
UMLS65 C0033802, C0157852, C0553730

Summaries for Chondrocalcinosis

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Wikipedia:68 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and... more...

MalaCards based summary: Chondrocalcinosis, also known as pseudogout, is related to chondrocalcinosis 2 and chondrocalcinosis with early-onset osteoarthritis. An important gene associated with Chondrocalcinosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator). Affiliated tissues include joint, b cells and bone, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Disease Ontology:10 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Related Diseases for Chondrocalcinosis

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Diseases in the Chondrocalcinosis family:

Chondrocalcinosis 2 Chondrocalcinosis Due to Apatite Crystal Deposition

Diseases related to Chondrocalcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1chondrocalcinosis 212.7
2chondrocalcinosis with early-onset osteoarthritis12.4
3chondrocalcinosis due to apatite crystal deposition12.3
4familial calcium pyrophosphate deposition11.8
5hypocalciuric hypercalcemia, type i10.5
6gitelman syndrome10.5
7familial hypopituitarism10.4AP2S1, CASR
8tumoral calcinosis, familial, normophosphatemic10.3
9familial tumoral calcinosis10.3
10familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome10.3
11epilepsy idiopathic generalized 810.3CASR, GNA11
12hypocalciuric hypercalcemia, type ii10.3
13hypocalciuric hypercalcemia, familial, type iii10.3
14breast cancer10.2
15congenital nervous system abnormality10.2ALPL, CASR
16marden-walker syndrome10.2REN, SLC12A3
17bartter syndrome, type 310.1REN, SLC12A3
18primary hyperparathyroidism10.1ALPL, CASR
19hypoinsulinemic hypoglycemia with hemihypertrophy10.1ALPL, ANKH
20leukodystrophy10.1ALPL, CASR
21chromophobe adenocarcinoma10.1REN, SLC12A3
22secondary lacrimal atrophy10.1ANKH, ENPP1
23cerebral lipidosis10.1REN, SLC12A3
24schizophrenia10.1
25bacteremia10.1
26attention deficit-hyperactivity disorder10.1
27testicular microlithiasis10.1
28otitis media10.1
29keratitis10.1
30brain injury10.1
31pulmonary emphysema10.1
32spinal muscular atrophy10.1
33traumatic brain injury10.1
34ophthalmomyiasis10.1
35fetal alcohol syndrome10.1
36lymphoma10.1
37body dysmorphic disorder10.1
38myoglobinuria10.1
39glucose intolerance10.1
40hypospadias10.1
41sarcoma10.1
42lyme disease10.1
43hypercalcemia10.1
44tuberous sclerosis10.1
45iritis10.1
46hypothyroidism10.1
47neuroendocrine tumor10.1
48thyroid cancer10.1
49klinefelter's syndrome10.1
50hypogonadism10.1

Graphical network of the top 20 diseases related to Chondrocalcinosis:



Diseases related to chondrocalcinosis

Symptoms for Chondrocalcinosis

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Drugs & Therapeutics for Chondrocalcinosis

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Drugs for Chondrocalcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ProbenecidapprovedPhase 02757-66-94911
Synonyms:
4-((Dipropylamino)sulfonyl)benzoic acid
4-(Di-N-propylsulfamoyl)benzoesaeure
4-(Di-n-propylsulfamoyl)benzoesaeure
4-(Dipropylsulfamoyl)benzoic acid
4-(N,N-Dipropylsulfamoyl)benzoesaeure
4-[(dipropylamino)sulfonyl]benzoic acid
57-66-9
AB00052080
AC-2023
AC1L1J86
AC1Q2XQM
AC1Q2XQN
AI3-50078
AKOS000165123
Apurina
BIDD:GT0626
BIDD:PXR0092
BPBio1_000643
BRD-K95237249-001-05-9
BRN 2815775
BSPBio_000583
BSPBio_002227
Bencid
Benecid
Benemid
Benemid (TN)
Benemide
Benuryl
Biokanol Brand of Probenecid
C07372
C13H19NO4S
CAS-57-66-9
CCRIS 3643
CHEBI:177474
CHEMBL897
CID4911
CPD000058280
Col-BENEMID
Col-Probenecid
ColBenemid (co mponent of)
ColBenemid (component of)
Colbenemid
D00475
D011339
DB01032
DivK1c_000056
EINECS 200-344-3
HMS1569N05
HMS1920J22
HMS2092C03
HMS500C18
HSDB 3387
I01-1905
ICN Brand of Probenecid
IDI1_000056
IDIS Brand of Probenecid
KBio1_000056
KBio2_001314
KBio2_003882
KBio2_006450
KBio3_001727
KBioGR_000971
KBioSS_001314
LS-33
MLS000028496
MLS001076472
Major Brand of Probenecid
Martec Brand of Probenecid
Merck Brand of Probenecid
MolPort-000-145-935
NCGC00016251-01
NCGC00016251-02
NCGC00023829-03
 
NCGC00023829-04
NCGC00023829-05
NCGC00023829-06
NCI-C56097
NINDS_000056
NSC 18786
NSC18786
Ophthalmic Brand of Probenecid
Oprea1_416955
P-(Dipropylsulfamoyl)benzoic acid
P8761_SIGMA
Panuric
Parabenem
Parmed Brand of Probenecid
Polycillin-BRB
Polycillin-PRB
Polycillin-PRB (component of)
Prestwick0_000542
Prestwick1_000542
Prestwick2_000542
Prestwick3_000542
Prestwick_809
Pro-Cid
Probalan
Probampacin
Probecid
Proben
Proben-C
Probenecid
Probenecid (JP15/USP/INN)
Probenecid Acid
Probenecid Major Brand
Probenecid Martec Brand
Probenecid Parmed Brand
Probenecid Weimer
Probenecid Zenith Brand
Probenecid [INN:BAN:JAN]
Probenecid acid
Probenecida
Probenecida [INN-Spanish]
Probenecide
Probenecide [INN-French]
Probenecidum
Probenecidum [INN-Latin]
Probenemid
Probenicid
Probenid
Probexin
Prolongine
Robenecid
SAM002554923
SBB028597
SMR000058280
SPBio_001327
SPBio_002504
SPECTRUM1500502
Spectrum2_001294
Spectrum3_000554
Spectrum4_000486
Spectrum5_001419
Spectrum_000834
Sulprin
Synergid R
Tubophan
UNII-PO572Z7917
Uricosid
Urocid
Valdecasas Brand of Probenecid
WLN: QVR DSWN3&3
Zenith Brand of Probenecid
p-(Dipropylsulfamoyl)benzoic acid
p-(Dipropylsulfamyl)benzoic acid
p-[Dipropylsulfamoyl]benzoic acid
probenecid
probenicid
2Calcium, DietaryPhase 04678
3Antirheumatic AgentsPhase 08496

Interventional clinical trials:

idNameStatusNCT IDPhase
1Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEMCompletedNCT01529099Phase 4
2Diagnostic Rentability of Screening for Associated Conditions in Calcium Pyrophosphate Deposition Disease PatientsCompletedNCT00453128
3Ultrasound and X-ray in Detecting Articular Cartilage CalcificationCompletedNCT00797537
4A Study to Evaluate BioMarkers in Blood Samples in Subjects With Rheumatoid ArthritisCompletedNCT01209585
5Effect of Probenecid on Synovial Fluid ATP Levels in CPPDRecruitingNCT02243631Phase 0
6Role of ASICs in Human Inflammatory PainRecruitingNCT01867840
7Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic TreatmentsRecruitingNCT01642706

Search NIH Clinical Center for Chondrocalcinosis


Cochrane evidence based reviews: chondrocalcinosis

Genetic Tests for Chondrocalcinosis

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Anatomical Context for Chondrocalcinosis

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MalaCards organs/tissues related to Chondrocalcinosis:

33
B cells, Bone, Breast, Kidney, Skin, Testes, Monocytes

FMA organs/tissues related to Chondrocalcinosis:

16
Joint

Animal Models for Chondrocalcinosis or affiliated genes

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MGI Mouse Phenotypes related to Chondrocalcinosis:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7CASR, ENPP1, GNA11, REN, SLC12A3
2MP:00053778.6ANKH, ENPP1, GNA11, TNFRSF11B
3MP:00053718.5ALPL, ANKH, GNA11, HFE, TNFRSF11B
4MP:00053698.3ALPL, ANKH, CASR, ENPP1, GNA11, REN
5MP:00053868.1ALPL, ANKH, CASR, ENPP1, GNA11, HFE
6MP:00053907.8ALPL, ANKH, CASR, ENPP1, GNA11, TNFRSF11B
7MP:00053767.7ALPL, ANKH, CASR, ENPP1, GNA11, HFE
8MP:00053857.4ALPL, ANKH, ENPP1, GNA11, REN, SLC12A3
9MP:00107687.1ALPL, ANKH, CASR, ENPP1, GNA11, HFE
10MP:00053787.0ALPL, ANKH, CASR, ENPP1, GNA11, HFE
11MP:00053976.9ALPL, ANKH, CASR, GNA11, HFE, REN
12MP:00053876.8ALPL, ANKH, CASR, ENPP1, GNA11, HFE

Publications for Chondrocalcinosis

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Articles related to Chondrocalcinosis:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Porphyria cutanea tarda and Sjogren's syndrome. (25054769)
2014
2
MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. (24423102)
2014
3
Modified Valsalva test differentiates primary from secondary cough headache. (23565708)
2013
4
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. (23275564)
2013
5
Novel nucleotide insertions in two unrelated Indian patients with 5I+ reductase 2 deficiency leading to premature termination of SRD5A2 enzyme. (24012728)
2013
6
Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. (24379621)
2013
7
Effect of downregulation of ZEB1 on vimentin expression, tumor migration and tumorigenicity of melanoma B16F10 cells and CSCs. (24339410)
2013
8
Integrin I^1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion. (23889963)
2013
9
Aspergillus nidulans and chronic granulomatous disease: a unique host-pathogen interaction. (22829648)
2012
10
Mechanism of lactic acidosis in children with acute severe asthma. (21460758)
2012
11
Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments. (21533195)
2011
12
Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure. (21490692)
2011
13
Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. (21464819)
2011
14
IL-1I+ mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut. (21479249)
2011
15
Castleman's disease of the neck: report of 4 cases with unusual presentations. (20708326)
2011
16
Mixed gonadal dysgenesis in a child with isodicentric Y chromosome: Does the relative proportion of the 45,X line really matter? (20583182)
2010
17
NGAL: a biomarker of acute kidney injury and other systemic conditions. (19582588)
2010
18
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. (20124183)
2010
19
RUNX3 protein is overexpressed in human epithelial ovarian cancer. (18937968)
2009
20
Cdc42GAP, reactive oxygen species, and the vimentin network. (19494238)
2009
21
Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression. (18497978)
2008
22
The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. (18362160)
2008
23
Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo. (16912056)
2007
24
Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling. (17581253)
2007
25
Hypothesis: Dent disease is an underrecognized cause of focal glomerulosclerosis. (17702731)
2007
26
Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. (16271751)
2006
27
A variant of the SYT-SSX2 fusion gene in a case of synovial sarcoma. (16682293)
2006
28
Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways. (16788091)
2006
29
Pediatric systemic lupus erythematosus in Siriraj Hospital. (16858852)
2005
30
Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. (16278295)
2005
31
The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. (16227627)
2005
32
Crystal structure of human heme oxygenase-1 in a complex with biliverdin. (15049686)
2004
33
Differential response to placebo among patients with social phobia, panic disorder, and obsessive-compulsive disorder. (15285978)
2004
34
Genotypic determinants of phenotype in North American patients with erythropoietic protoporphyria. (14567969)
2003
35
Mucosa-associated lymhpoid tissue (MALT) lymphoma of the jejunum and Helicobacter pylori--chance association? (12952237)
2003
36
Structure-based description of a step-by-step synthesis of homo- and heterodinuclear (4f, 4f ') lanthanide complexes. (14514333)
2003
37
Erythropoietin requirements: a comparative multicenter study between peritoneal dialysis and hemodialysis. (14733416)
2003
38
Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. (12207345)
2002
39
Deficiency of chaperonin 60 in Down's syndrome. (12515899)
2002
40
Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. (11272145)
2001
41
Effects of energostim on the sympathoadrenal system and contents of pyridine nucleotides during acute myocardial infarction. (12152878)
2001
42
Further family with possible autosomal recessive inheritance of Adams-Oliver syndrome. (10440839)
1999
43
Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. (9841852)
1999
44
Bcl-2, Bcl-X, Bax, and Bak expression in short- and long-lived patients with diffuse large B-cell lymphomas. (10537354)
1999
45
Cervical spondylitis and epidural abscess caused by Salmonella enteritidis with tetraplegia. (9867305)
1998
46
Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli. (9639321)
1998
47
Nuclear translocation of the Y-box binding protein by ultraviolet irradiation. (9409758)
1997
48
Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells. (8827774)
1996
49
Bioactive tumour necrosis factor alpha in pre-eclamptic patients with and without the HELLP syndrome. (7826964)
1994
50
Drug treatment of hypertension. (8361133)
1993

Variations for Chondrocalcinosis

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Expression for genes affiliated with Chondrocalcinosis

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Search GEO for disease gene expression data for Chondrocalcinosis.

Pathways for genes affiliated with Chondrocalcinosis

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GO Terms for genes affiliated with Chondrocalcinosis

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Biological processes related to Chondrocalcinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:003050510.4ANKH, ENPP1
2response to lipopolysaccharideGO:00324968.8ALPL, REN, TNFRSF11B

Sources for Chondrocalcinosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet