MCID: CHN010
MIFTS: 42

Chondroma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Chondroma

Aliases & Descriptions for Chondroma:

Name: Chondroma 12 50 52 42 14 69
Central Chondroma 12
Chondroma Nos 12
Enchondroma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 42 D002812
NCIt 47 C53459
UMLS 69 C0936248

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to paraganglioma and gastric stromal sarcoma and gastrointestinal stromal tumor, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Carbon metabolism and Wnt / Hedgehog / Notch. Affiliated tissues include tongue, bone and lung, and related phenotypes are mortality/aging and embryo

Wikipedia : 71 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 paraganglioma and gastric stromal sarcoma 29.4 SDHB SDHC SDHD
2 gastrointestinal stromal tumor 29.0 ACTC1 SDHB SDHC SDHD
3 extraskeletal chondroma 12.2
4 juxtacortical chondroma 12.0
5 central nervous system chondroma 11.8
6 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 11.7
7 phalanx chondroma 11.7
8 carney triad 11.1
9 carpotarsal osteochondromatosis 10.9
10 paragangliomas 1, with or without deafness 10.8
11 chondroid chordoma 10.8
12 periostitis 10.5
13 pelvic lipomatosis 10.2 HMGA2 SDHB
14 catastrophic antiphospholipid syndrome 10.2 SDHB SDHD
15 acrocapitofemoral dysplasia 10.2 SDHB SDHD
16 bone ameloblastoma 10.2 SDHB SDHD
17 temporal lobe neoplasm 10.2 CTNNB1 HMGA2
18 laryngitis 10.2
19 chondrosarcoma 10.1
20 intestinal pseudo-obstruction 10.1 CTNNB1 GLI1
21 papillary adenoma 10.1 HMGA2 SDHB
22 paraganglioma 10.1
23 childhood central nervous system primitive neuroectodermal neoplasm 10.1 CTNNB1 GLI1
24 male urethral cancer 10.1 ACTC1 CTNNB1
25 cervicitis 10.1
26 house allergic alveolitis 10.1 ACTC1 HMGA2
27 pilar sheath acanthoma 10.1 ACTC1 HMGA2
28 central hypoventilation syndrome, congenital 10.1 SDHB SDHD
29 neuropathy, congenital, with arthrogryposis multiplex 10.0 SDHB SDHC SDHD
30 fitz-hugh-curtis syndrome 10.0 ACTC1 CTNNB1
31 intravenous leiomyomatosis 10.0 SDHB SDHC SDHD
32 endocervical adenocarcinoma 10.0 SDHB SDHC SDHD
33 glioma susceptibility 2 10.0 SDHB SDHC SDHD
34 amaurosis congenita, cone-rod type, with congenital hypertrichosis 10.0 SDHB SDHC SDHD
35 cardiac arrest 10.0 SDHB SDHC SDHD
36 cowden syndrome 3 10.0 SDHB SDHC SDHD
37 glycogen storage disease ic 10.0 SDHB SDHC SDHD
38 non-syndromic male infertility due to sperm motility disorder 10.0 SDHB SDHC SDHD
39 neurofibromatosis-noonan syndrome 10.0 SDHB SDHC SDHD
40 isolated methylmalonic acidemia 10.0 SDHB SDHC SDHD
41 extragonadal germ cell cancer 10.0 CTNNB1 GLI1
42 non-syndromic x-linked intellectual disability 10.0 SDHB SDHC SDHD
43 carotenemia 10.0 SDHB SDHC SDHD
44 zollinger-ellison syndrome 10.0 SDHB SDHC SDHD
45 childhood teratocarcinoma of the testis 10.0 SDHB SDHC SDHD
46 erythrocytosis, familial, 2 10.0 SDHB SDHC SDHD
47 popliteal pterygium syndrome, bartsocas-papas type 10.0 ACTC1 CTNNB1
48 benign shuddering attacks 10.0 SDHB SDHC SDHD
49 leiomyosarcoma 10.0
50 impaired renal function disease 10.0 PTH1R SDHB

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

MGI Mouse Phenotypes related to Chondroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.56 ACTC1 CTNNB1 GLI1 MIB1 PTH1R SDHB
2 embryo MP:0005380 9.55 CTNNB1 GLI1 MIB1 PTH1R SDHD
3 normal MP:0002873 9.1 ACTC1 CTNNB1 GLI1 MIB1 SDHB SDHD

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2
2 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

39
Tongue, Bone, Lung, Spinal Cord, Trachea, Liver, Breast

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 550)
id Title Authors Year
1
Trigger Finger Caused by Extraskeletal Chondroma. ( 27817941 )
2017
2
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. ( 27185409 )
2016
3
Intracranial dural based chondroma. ( 26602798 )
2016
4
Breast Chondroma. ( 27797122 )
2016
5
Scrotal chondroma in a young male: A rare case report. ( 27166053 )
2016
6
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. ( 27602219 )
2016
7
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. ( 27179652 )
2016
8
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. ( 27461824 )
2016
9
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. ( 27213734 )
2016
10
Case report of chondroma in a grass carp (Ctenopharyngodon idella). ( 27482364 )
2016
11
A case of chondroma cutis showing callus-like appearance. ( 26932734 )
2016
12
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? ( 27026930 )
2016
13
Intradural chondroma in the cervical spine: case report. ( 27740393 )
2016
14
Periosteal chondroma of the femur: A case report and review of the literature. ( 25789014 )
2015
15
Orbital Chondroma: A rare mesenchymal tumor of orbit. ( 26265654 )
2015
16
Chondroma of Cerebral Falx: A Rare Intracranial Diagnosis. ( 26454394 )
2015
17
Extraskeletal Chondroma in the Popliteal Region: A Case Report. ( 26960310 )
2015
18
A rare case of bladder chondroma. ( 25844100 )
2015
19
Novel Pathologic Finding of Digital Soft Tissue Chondroma in a Child: A Case Report and Review of Literature. ( 26113665 )
2015
20
Extraosseous chondroma of anterior neck in pediatric patient. ( 26104481 )
2015
21
Primary spinal extraosseous cervical chondroma in an adult. ( 25751486 )
2015
22
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. ( 26091072 )
2015
23
Periosteal chondroma of the distal tibia: Computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. ( 26137286 )
2015
24
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. ( 26918096 )
2015
25
Nasal chondroma presenting as hypertelorism. ( 25730333 )
2015
26
Endobronchial chondroma: An unusual case of bronchial obstruction. ( 25770939 )
2015
27
Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review. ( 26834817 )
2015
28
Bilateral extraskeletal chondroma of the neck. ( 26381679 )
2015
29
Soft tissue chondroma presenting as a dermal mass in the toe. ( 26015904 )
2015
30
Extensive Periosteal Chondroma in the Middle Phalanx with Pathological Fracture Reconstructed with Strut Bone Grafting. ( 26051780 )
2015
31
Extraskeletal Chondroma of the Gluteal Region Along with Sporadic Neurofibroma - An Unusual Presentation. ( 26155485 )
2015
32
True cutaneous chondroma: a case report. ( 25998426 )
2015
33
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. ( 26156668 )
2015
34
Chondroma of the falx cerebri. ( 25909200 )
2015
35
Arytenoid cartilage chondroma. ( 25960446 )
2015
36
Chondroma of the scalp. ( 26405500 )
2015
37
Chondroblastoma-like chondroma of the hand: case report. ( 24656394 )
2014
38
An uncommon cause of anterior knee pain: patellar chondroma. ( 23669736 )
2014
39
Falx chondroma with hyperostosis of the scull: a case report. ( 25233692 )
2014
40
Imaging features of periosteal chondroma manifesting as a subcutaneous mass in the index finger. ( 24778891 )
2014
41
A rare case of chondroma of falx cerebri. ( 25269052 )
2014
42
Chondroma of the diaphragm mimicking a giant liver tumor with calcification: report of a case. ( 24931544 )
2014
43
Arytenoid cartilage chondroma. ( 25181657 )
2014
44
Focal periosteal chondroma of the hand: a review of 24 cases. ( 25172018 )
2014
45
Convexity dural chondroma: a case report with pathological and molecular analysis. ( 25250651 )
2014
46
Intracranial extra-axial chondroma: a case report. ( 24614393 )
2014
47
A rare case of chondroma of the parotid gland. ( 24868998 )
2014
48
A rare case of giant soft tissue chondroma of the wrist: A cytopathological study with review of the literature. ( 25190983 )
2014
49
Extraskeletal chondroma of the foot-a case report. ( 24783107 )
2014
50
Imaging features of juxtacortical chondroma in children. ( 23955368 )
2014

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 9.16 CTNNB1 HMGA2
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.7 ACTC1 CTNNB1 HMGA2
2 positive regulation of cell proliferation GO:0008284 9.56 CTNNB1 GLI1 HMGA2 PTH1R
3 dorsal/ventral pattern formation GO:0009953 9.51 CTNNB1 GLI1
4 chondrocyte differentiation GO:0002062 9.49 HMGA2 PTH1R
5 epithelial to mesenchymal transition GO:0001837 9.48 CTNNB1 HMGA2
6 cell maturation GO:0048469 9.46 CTNNB1 PTH1R
7 pituitary gland development GO:0021983 9.43 GLI1 HMGA2
8 aerobic respiration GO:0009060 9.4 SDHB SDHC
9 bone resorption GO:0045453 9.37 CTNNB1 PTH1R
10 proximal/distal pattern formation GO:0009954 9.32 CTNNB1 GLI1
11 epithelial tube branching involved in lung morphogenesis GO:0060441 9.16 CTNNB1 HMGA2
12 regulation of osteoblast differentiation GO:0045667 8.96 CTNNB1 GLI1
13 tricarboxylic acid cycle GO:0006099 8.8 SDHB SDHC SDHD

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 electron carrier activity GO:0009055 9.43 SDHB SDHC SDHD
2 SMAD binding GO:0046332 9.32 CTNNB1 HMGA2
3 ubiquinone binding GO:0048039 9.16 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.96 SDHB SDHD
5 succinate dehydrogenase activity GO:0000104 8.62 SDHC SDHD

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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