MCID: CHN010
MIFTS: 50

Chondroma malady

Summaries for Chondroma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards: Chondroma, also known as central chondroma, is related to paraganglioma and carney triad. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Pyruvate metabolism. The compounds cycloheximide and fumarate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

chondroma 8 43 10 45 61
central chondroma 8
chondroma nos 8


External Ids:

Disease Ontology8 DOID:2602
NCIt40 C53459
MeSH35 D002812

Related Diseases for Chondroma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma30.6IDH2, SDHB, SDHC, SDHA, S100A1, KIT
2carney triad30.6PDGFRA, SDHC, SDHD, KIT, SDHB
3ollier disease30.3PTHLH
4chondroblastoma30.2PTHLH
5ependymoma29.8PDGFRA, MDM2
6gastrointestinal stromal tumor29.8PDGFRA, KIT
7adenoma29.8S100A1, CDK4, CTNNB1, HMGA2
8astrocytoma29.8SERPINA3, MDM2, PDGFRA, IDH1, CDK4
9squamous cell carcinoma29.8PDGFRA, S100A1, CTNNB1, MDM2, GLI1, CDK4
10extraskeletal chondroma10.7
11juxtacortical chondroma10.5
12osteochondroma10.3
13gastric leiomyosarcoma10.3
14pulmonary function10.3
15periosteal chondrosarcoma10.2
16enchondroma10.2
17central nervous system chondroma10.1
18asthma10.1
19choristoma10.1
20radiculopathy10.1
21carpal tunnel syndrome10.1
22epithelioid leiomyosarcoma10.1
23carpotarsal osteochondromatosis10.1
24meningioma10.0S100A1
25gliosarcoma10.0CDK4
26arthritis10.0SERPINA3
27dermatofibrosarcoma10.0MDM2
28basal cell carcinoma10.0GLI1
29renal oncocytoma10.0S100A1
30seminal vesicle tumor10.0SDHA
31cervical cancer10.0MDM2
32acute leukemia10.0KIT
33pheochromocytoma10.0SDHB, SDHD
34craniopharyngioma10.0CTNNB1
35pituitary adenoma10.0HMGA2, CDK4
36uterine carcinosarcoma10.0KIT
37hereditary paraganglioma-pheochromocytoma syndromes10.0SDHC, SDHD, SDHB
38von hippel-lindau disease10.0SDHD, SDHB, SDHC
39hemangioma10.0SDHC, SDHB, SDHD
40paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
41carotid body tumor10.0SDHD, SDHB, SDHC
42multiple endocrine neoplasia10.0SDHC, SDHD, SDHB
43thymic carcinoma10.0KIT
44myeloma10.0PTHLH
45multiple endocrine neoplasia type 2a10.0SDHD, SDHC, SDHB
46interval angle-closure glaucoma10.0IDH1, IDH2
47malignant mesothelioma10.0S100A1, CDK4
48pilocytic astrocytoma10.0CDK4, IDH1
49wermer syndrome10.0SDHC, SDHD, SDHB
50prolactinoma10.0PTHLH, HMGA2

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Clinical Features for Chondroma

Drugs & Therapeutics for Chondroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Chondroma

Drug clinical trials:

Search ClinicalTrials for Chondroma

Search NIH Clinical Center for Chondroma

Search CenterWatch for Chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

Animal Models for Chondroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chondroma

Sources:
51PubMed
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Articles related to Chondroma:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Primary synovial chondromatosis of the ankle joint presenting as monoarthritis. (24326442)
2013
2
Extraskeletal chondroma of anterior abdominal wall in a child. (24381850)
2013
3
Soft tissue chondroma mimicking "dumbbell" neurogenic tumour: A rare cause of lumbar radiculopathy. (24380757)
2013
4
Periosteal chondroma of the proximaltibia mimicking Osgood-Schlatter's disease. (23610879)
2013
5
Synovial chondromatosis of the temporomandibular joint: radiologic and histopathologic findings. (22801131)
2012
6
Metaphyseal chondromatosis combined with D-2-hydroxyglutaric aciduria in four patients. (22639207)
2012
7
Wrist synovial chondromatosis: case report and literature review. (22745090)
2012
8
Chondroma in temporomandibular region--case report and therapeutic considerations. (21072549)
2012
9
Synovial chondromatosis. (22010324)
2011
10
Anterior knee pain: the pitfalls of plica and chondromalacia patellae. (21699003)
2011
11
Synovial chondromatosis of the elbow causing a mechanical block to range of motion: a case report and review of the literature. (21734934)
2011
12
Synovial chondromatosis of temporomandibular joint: journey through 25 decades and a case report. (21470750)
2011
13
Long-term results after arthroscopic treatment of synovial chondromatosis of the shoulder. (18308184)
2008
14
Interventional radiology of synovial chondromatosis in the temporomandibular joint using a thin arthroscope. (18460578)
2008
15
Secondary synovial chondromatosis in a bursa overlying an osteochondroma mimicking a peripheral chondrosarcoma -- a case report. (17966034)
2007
16
Laparoscopic presentation of a rib chondroma. (14676003)
2004
17
Synovial chondromatosis of the metacarpophalangeal joint. (11895357)
2002
18
Chondroma in the bony external ear canal. (12405083)
2002
19
Snapping plicae associated with radiocapitellar chondromalacia. (11337715)
2001
20
Chondroblastoma-like chondroma of soft tissue: an underrecognized variant and its differential diagnosis. (11342780)
2001
21
Posterior interosseous nerve palsy caused by synovial chondromatosis of the elbow joint. (11428805)
2001
22
Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases. (10422030)
1999
23
Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potential. (9670824)
1998
24
Dural chondroma with fat tissue. (9265964)
1997
25
Intracapsular chondroma of the knee. (9090627)
1997
26
Tracheal resection and anastomosis for an intratracheal chondroma in a ball python. (8756880)
1996
27
Synovial chondromatosis. (7644946)
1995
28
Laryngeal chondroma: an unusual cause of upper airway obstruction. (7789028)
1995
29
Immunohistochemical study on collagenous proteins and biophysical analysis of crystals in extraskeletal chondroma. (7496505)
1995
30
Locking wrist with synovial chondromatosis: report of two cases. (7806803)
1994
31
Intra-tendinous chondroma of a flexor tendon. (1779169)
1991
32
Effect of lateral release on patellar motion in chondromalacia. An MRI study of 11 knees. (2402979)
1990
33
An electron microscopic study of early pathology in chondromalacia of the patella. (2732274)
1989
34
Synovial chondromatosis of the temporomandibular joint. (3143778)
1988
35
Ossifying parasellar chondroma. Case report. (3117983)
1987
36
Extra-adrenal paraganglioma and pulmonary chondroma: a case report and review of the literature. (2884350)
1987
37
Choroid plexus papilloma with chondroma: case report. (3736808)
1986
38
Multilobular osteoma (chondroma rodens) in a horse. (6826457)
1983
39
Chondromalacia of the patella. (7161392)
1982
40
Synovial chondromatosis of the hand. (7071234)
1982
41
Chondromalacia of the patella: an unusual presentation. (7221395)
1981
42
Chondromalacia as a separate entity: new perspectives on osteoarthrosis. (554706)
1979
43
Chondromalacia and the unstable patella. (1180030)
1975
44
Chondroma of the tongue. (5285192)
1971
45
Intracranial solitary chondroma of dural origin. (5459528)
1970
46
Second primary laryngeal chondroma. (5765801)
1969
47
Case reports and technical notes. Chondroma of the cervical spine. Case report. (5684408)
1968
48
An unusual case of hamarto-chondroma. (13719765)
1960
49
Chondromalacia of the patella. (13221987)
1955
50
Primary chondroma of the lung. (14391170)
1955

Genetic Variations for Chondroma

Expression for genes affiliated with Chondroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

Sources:
12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Chondroma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5RUNX2
2fumarate45 1111.2SDHC, SDHB, SDHD
3UBIQUINONE-11110.0SDHB, SDHC, SDHD, SDHA
42-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHA, SDHC, SDHB, SDHD
5isocitrate4510.0IDH1, IDH2, SDHB
6succinic acid29 11 2412.0SDHA, SDHC, SDHB, SDHD
7iron-sulfur4510.0SDHB, SDHD, SDHC, SDHA
8ubiquinone4510.0SDHB, SDHA, SDHC, SDHD
9naphthol as-d chloroacetate4510.0KIT, SERPINA3
10succinate4510.0SDHD, SDHB, SDHA, SDHC
11thenoyltrifluoroacetone45 1111.0SDHA, SDHB
12ag-1296459.8PTHLH, PDGFRA, KIT
13somatropin recombinant50 1110.7CDK4, TSPAN31
14paclitaxel45 50 1111.6CDK4, MDM2, CTNNB1
15lead459.5PTHLH, MDM2, CDK4, KIT
16dexamethasone45 50 29 1112.5MDM2, CDK4, CTNNB1
17glucose459.5GLI1, SERPINA3, SDHB, RUNX2, PTHLH
18glyceraldehyde 3-phosphate459.5SDHA, IDH1, SDHB, MDM2
19valine459.4MDM2, KIT, PTHLH, SERPINA3, CDK4
20roscovitine459.4CDK4, CTNNB1, RUNX2, MDM2
21leptomycin b45 6010.3CTNNB1, LPP, PTHLH, MDM2
22trastuzumab45 50 1111.3CTNNB1, MDM2, CDK4, KIT
23steroid459.3CDK4, PTHLH, SERPINA3, SDHC, RUNX2, MDM2
24gefitinib45 50 1111.3MDM2, KIT, CDK4, CTNNB1
25geldanamycin45 50 60 1112.3KIT, MDM2, CTNNB1, CDK4
26tgf beta1459.1CDK4, PTHLH, CTNNB1, PDGFRA, RUNX2
27imatinib45 50 1111.1KIT, CTNNB1, PDGFRA, MDM2
28doxorubicin45 50 1111.0KIT, HMGA2, MDM2, CDK4, CTNNB1
29arginine458.9CTNNB1, SERPINA3, SDHB, MDM2, PTHLH, CDK4
30rapamycin458.9PDGFRA, CDK4, KIT, MDM2, CTNNB1
31testosterone45 60 11 2411.8MDM2, CDK4, KIT, CTNNB1, SDHB, PTHLH
32pd 98,059458.7MDM2, GLI1, CDK4, CTNNB1, KIT, RUNX2
33alanine458.7RUNX2, PTHLH, SDHB, SERPINA3, CDK4, MDM2
34oxygen45 249.6SDHD, RUNX2, CDK4, PTHLH, SDHC, SDHA
35cisplatin45 50 60 1111.6CTNNB1, MDM2, CDK4, HMGA2, PTHLH
36thymidine45 249.4KIT, CDK4, MDM2, CTNNB1, PDGFRA, RUNX2
37iron45 249.4CDK4, SDHA, SDHC, SDHB, SDHD, S100A1
38threonine458.4PTHLH, MDM2, CDK4, KIT, CTNNB1, SERPINA3
39zinc45 249.4SDHB, RUNX2, S100A1, MDM2, GLI1, CDK4
40oligonucleotide458.4SERPINA3, MDM2, CTNNB1, KIT, PDGFRA, RUNX2
41phosphatidylinositol458.1KIT, GLI1, MDM2, CTNNB1, PDGFRA, RUNX2
42glycogen45 249.1MDM2, CTNNB1, S100A1, PTHLH, CDK4, KIT
43progesterone45 60 29 11 2412.1MDM2, CTNNB1, KIT, CDK4, SERPINA3, S100A1
44nitric oxide45 11 2410.0PTHLH, KIT, MDM2, CDK4, S100A1, RUNX2
45vegf458.0PDGFRA, RUNX2, CDK4, KIT, PTHLH, SDHB
46cysteine457.9CTNNB1, S100A1, MDM2, CDK4, SERPINA3, SDHB
47paraffin457.5CTNNB1, PDGFRA, S100A1, KIT, MDM2, CDK4
48calcium45 50 11 2410.3MDM2, KIT, PDGFRA, S100A1, RUNX2, CDK4
49retinoic acid45 248.3S100A1, PDGFRA, SDHC, SERPINA3, PTHLH, HMGA2
50tyrosine457.3CTNNB1, RUNX2, SDHB, PTHLH, KIT, CDK4

GO Terms for genes affiliated with Chondroma

Sources:
16Gene Ontology
See all sources

Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7HMGA2, CTNNB1
2mitochondrial respiratory chain complex IIGO:0057499.6SDHA, SDHC, SDHB, SDHD
3mitochondrial inner membraneGO:0057439.2IDH2, SDHD, SDHB, SDHC, SDHA
4nucleusGO:0056345.7RUNX2, S100A1, PDGFRA, CTNNB1, MDM2, LPP

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.1IDH1, IDH2
2isocitrate metabolic processGO:00610210.0IDH2, IDH1
3respiratory electron transport chainGO:0229049.7SDHA, SDHC, SDHB, SDHD
4negative regulation of chondrocyte differentiationGO:0323319.7PTHLH, CTNNB1
5stem cell differentiationGO:0488639.7RUNX2, KIT, HMGA2
6succinate metabolic processGO:0061059.7SDHA, SDHB
7positive regulation of phospholipase C activityGO:0108639.6KIT, PDGFRA
8cellular metabolic processGO:0442379.5IDH2, SDHD, SDHB, SDHC, SDHA
9tricarboxylic acid cycleGO:0060999.3SDHA, IDH1, IDH2, SDHD, SDHB, SDHC
10odontogenesis of dentin-containing toothGO:0424759.2RUNX2, PDGFRA, CTNNB1
11positive regulation of cell proliferationGO:0082847.9RUNX2, PDGFRA, MDM2, GLI1, CDK4, KIT

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
2succinate dehydrogenase (ubiquinone) activityGO:0081779.9SDHA, SDHB
3ubiquinone bindingGO:0480399.8SDHB, SDHD
4protein bindingGO:0055155.8LPP, MDM2, CTNNB1, PDGFRA, S100A1, GLI1

Products for genes affiliated with Chondroma

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Sources for Chondroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet