Chondroma malady

Wikipedia: A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern.⁴⁴ more...

MalaCards: Chondroma, also known as chondroma nos (morphologic abnormality), is related to enchondroma and ollier disease. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Parkinsons disease and Oxidative phosphorylation. The compounds roscovitine and fumarate have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Disease Ontology: A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.⁶

Aliases & Descriptions:

chondroma 6 30 8 32 43 chondroma nos (morphologic abnormality) 6 chondroma (morphologic abnormality) 6

central chondroma 6 enchondroma 43

Diseases related to chondroma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 191)

id	Related Disease	Score	Top Affiliating Genes
1	enchondroma	32.7	IDH1, IDH2, PTHLH
2	ollier disease	30.9	IDH1, IDH2, PTHLH
3	spindle cell hemangioma	28.5	IDH1, IDH2
4	hemangioma	27.6	SDHB, SDHC, SDHD, IDH1, IDH2
5	carney triad	27.5	KIT, SDHA, SDHB, SDHC, SDHD, PDGFRA
6	ring chromosomes	27.3	CDK4, MDM2, GLI1, HMGA2
7	paraganglioma	25.7	KIT, SDHA, SDHB, SDHC, SDHD, S100A1
8	chondrosarcoma	24.0	SERPINA3, S100A1, CDK4, MDM2, IDH1, IDH2
9	sarcoma	21.3	KIT, SERPINA3, SDHA, SDHB, SDHC, SDHD
10	cowden-like syndrome	13.5	SDHB, SDHD
11	interval angle-closure glaucoma	13.5	IDH1, IDH2
12	cranial nerve palsy	13.4	SDHC, SDHD
13	seminal vesicle tumor	13.4	SDHA, SDHB
14	paraganglioma and gastric stromal sarcoma	13.4	SDHB, SDHC, SDHD
15	hereditary paraganglioma-pheochromocytoma syndromes	13.4	SDHB, SDHC, SDHD
16	carotid body tumor	13.4	SDHB, SDHC, SDHD
17	familial medullary thyroid carcinoma	13.4	SDHB, SDHC, SDHD
18	familial renal cell carcinoma	13.4	SDHB, SDHC, SDHD
19	d-2-hydroxyglutaric aciduria	13.4	IDH1, IDH2
20	multiple endocrine neoplasia type 2a	13.4	SDHB, SDHC, SDHD
21	intraductal papilloma	13.4	IDH1, IDH2
22	wermer syndrome	13.4	SDHB, SDHC, SDHD
23	adrenal adenoma	13.3	SDHB, SDHC, SDHD
24	2-hydroxyglutaric aciduria	13.3	IDH1, IDH2
25	glomus tumor	13.3	SDHB, SDHD, S100A1
26	soft tissue neoplasm	13.2	CDK4, MDM2
27	spindle cell liposarcoma	13.2	CDK4, MDM2
28	epithelioid leiomyosarcoma	13.2	SERPINA3, PTHLH
29	inflammatory myofibroblastic tumor	13.1	S100A1, CDK4, HMGA2
30	mitochondrial complex ii deficiency	13.1	SDHA, SDHB, SDHC, SDHD
31	neural crest tumor	13.1	SDHA, SDHB, SDHC, SDHD
32	retroperitoneal sarcoma	13.1	CDK4, MDM2
33	myxoid liposarcoma of the ovary	13.1	CDK4, MDM2
34	retroperitoneal leiomyosarcoma	13.0	KIT, S100A1
35	pleomorphic adenoma	13.0	S100A1, MDM2, HMGA2
36	atypical lipomatous tumor	13.0	CDK4, MDM2, HMGA2
37	multiple endocrine neoplasia	13.0	SDHB, SDHC, SDHD, CDK4
38	oligoastrocytoma	13.0	IDH1, PDGFRA
39	rosai-dorfman disease	13.0	SERPINA3, S100A1, PDGFRA
40	chondroblastoma	13.0	SERPINA3, S100A1, PTHLH
41	spindle cell lipoma	12.9	S100A1, CDK4, MDM2
42	pleomorphic liposarcoma	12.9	KIT, MDM2
43	gliomatosis cerebri	12.9	MDM2, IDH1
44	gastrointestinal stromal tumor, somatic	12.9	KIT, PDGFRA
45	adenoid cystic carcinoma	12.8	KIT, SERPINA3, S100A1
46	dysgerminoma of ovary	12.8	KIT, PTHLH
47	mucoepidermoid carcinoma	12.8	SERPINA3, S100A1, MDM2, HMGA2
48	nasopharynx carcinoma	12.8	SDHC, SDHD, CDK4, MDM2
49	renal oncocytoma	12.8	KIT, SDHB, S100A1
50	smooth muscle tumor	12.8	KIT, S100A1, HMGA2

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to chondroma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	HMGA2, RUNX2
2	reproductive system phenotype	MP:0005389	9.4	PDGFRA, HMGA2, GLI1
3	tumorigenesis	MP:0002006	7.7	PDGFRA, GLI1, MDM2, CDK4, SDHD, KIT
4	integument phenotype	MP:0010771	INF	RUNX2, PDGFRA, , HMGA2, MDM2, CDK4
5	limbs/digits/tail phenotype	MP:0005371	INF	KIT, RUNX2, PDGFRA, , HMGA2, GLI1
6	craniofacial phenotype	MP:0005382	INF	RUNX2, PDGFRA, , HMGA2, MDM2, KIT
7	cardiovascular system phenotype	MP:0005385	INF	RUNX2, PDGFRA, , MDM2, CDK4, S100A1
8	digestive/alimentary phenotype	MP:0005381	INF	RUNX2, PDGFRA, , GLI1, MDM2, CDK4

Articles related to chondroma:

id	Title	Authors	Year	Affiliating Genes
1	IDH1 and IDH2 mutations are frequent events in centra l chondrosarcoma and central and periosteal chondromas but not in other mesench ymal tumours. (21598255)	Amary M.F.... Flanagan A.M.	2011	IDH1, IDH2
2	The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gas tric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clini cal implications. (19522824)	Stratakis C.A.... Carney J.A.	2009	SDHA, SDHC, SDHD
3	Chondroma of the cheek: A case report. (15955665)	Onodera K.... Ooya K.	2005	S100A1
4	Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. (14614053)	Dahlen A.... Panagopoulos I.	2003	HMGA2
5	Cell proliferation and expression of Cbfa-1 in a peripheral osteo-chondroma arising from the mandibular oral mucosa of an edentulous alveolar ridge. (12455237)	Matsuzaka K.... Inoue T.	2002	RUNX2
6	Supernumerary ring chromosomes derived from the long arm of chromosome 12 as the primary cytogenetic anomaly in a rare soft tissue chondroma. (10748295)	Shadan F.F.... Stock A.D.	2000	CDK4, MDM2, GLI1
7	Extraskeletal chondroma with chondroblastic and granu loma-like elements. (7634679)	Yamada T.... Tokunaga O.	1995	SERPINA3

Genes related to chondroma according to GeneCards:

(show all 18)

id	Symbol	Description	Score	GeneCards Section Context
1	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
2	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
3	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0	Publications
4	HMGA2	high mobility group AT-hook 2	11.0	Publications
5	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0
6	TSPAN31	tetraspanin 31	11.0
7	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	11.0	Publications
8	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
9	S100A1	S100 calcium binding protein A1	11.0	Publications
10	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0	Publications
11	GLI1	GLI family zinc finger 1	11.0	Publications
12	RUNX2	runt-related transcription factor 2	11.0	Publications
13	CDK4	cyclin-dependent kinase 4	11.0	Publications
14	LHFP	lipoma HMGIC fusion partner	11.0
15	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
16	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
17	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0
18	LPP	LIM domain containing preferred translocation partner in lipoma	11.0

Pathways related to chondroma according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Parkinsons disease20	9.7	SDHD, SDHC, SDHB, SDHA
2	Oxidative phosphorylation20	9.7	SDHD, SDHC, SDHB, SDHA
3	Alzheimers disease20	9.6	SDHD, SDHC, SDHB, SDHA
4	Huntingtons disease20	9.6	SDHA, SDHB, SDHC, SDHD
5	Citric acid cycle (TCA cycle)38	9.5	IDH2, SDHD, SDHC, SDHB, SDHA
6	Citrate cycle (TCA cycle)20	9.2	SDHA, SDHB, SDHC, SDHD, IDH1, IDH2
7	Glioma20	8.9	PDGFRA, MDM2, CDK4
8	Glioblastoma Multiforme36	8.9	CDK4, MDM2, PDGFRA
9	Melanoma20	8.8	CDK4, MDM2, PDGFRA
10	Pathways in cancer20	8.8	PDGFRA, GLI1, MDM2, CDK4
11	Pancreatic Adenocarcinoma36	7.8	PDGFRA, MDM2, CDK4, KIT
12	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	INF	GLI1, , RUNX2
13	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	INF	GLI1, , RUNX2

Compounds related to chondroma according to GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	roscovitine32	10.4	RUNX2
2	fumarate32 9 9	12.2	SDHB, SDHC, SDHD
3	Isocitric Acid9 18 9	12.2	IDH2, IDH1
4	thenoyltrifluoroacetone32 9 9	12.2	SDHB, SDHA
5	isocitrate32	10.0	SDHB, IDH1, IDH2
6	UBIQUINONE-19 9	10.9	SDHA, SDHB, SDHC, SDHD
7	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol9 9	10.9	SDHD, SDHC, SDHB, SDHA
8	Succinic acid9 18 9	11.9	SDHD, SDHC, SDHB, SDHA
9	iron-sulfur32	9.9	SDHD, SDHC, SDHB, SDHA
10	ubiquinone32	9.9	SDHD, SDHC, SDHB, SDHA
11	succinate32	9.9	SDHD, SDHC, SDHB, SDHA
12	naphthol as-d chloroacetate32	9.8	KIT, SERPINA3
13	estrogen32	9.5	RUNX2, PDGFRA, S100A1, SERPINA3
14	glyceraldehyde 3-phosphate32	9.3	SDHA, SDHB, MDM2, IDH1
15	pkc 41232	9.1	KIT, PDGFRA
16	nad+32	9.0	MDM2, SDHB, SDHA
17	flavopiridol32 9 9	10.9	KIT, CDK4, MDM2
18	trastuzumab32 34 9 9	11.8	MDM2, CDK4, KIT
19	gefitinib32 34 9 9	11.7	KIT, CDK4, MDM2
20	geldanamycin32 9 9	10.5	KIT, CDK4, MDM2
21	iron32 18	9.4	MDM2, CDK4, S100A1, SDHD, SDHC, SDHB
22	zinc32 18	9.3	RUNX2, GLI1, MDM2, CDK4, S100A1, SDHB
23	pd 98,05932	8.2	RUNX2, GLI1, MDM2, CDK4, KIT
24	oligonucleotide32	7.8	RUNX2, PDGFRA, MDM2, CDK4, SERPINA3, KIT
25	glycogen32 18	INF	, MDM2, CDK4, S100A1, SDHB, KIT
26	tgf beta132	INF	CDK4, , PDGFRA, RUNX2
27	steroid32	INF	RUNX2, , MDM2, CDK4, SDHC, SERPINA3
28	glucose32	INF	RUNX2, , GLI1, CDK4, SDHB, SERPINA3
29	retinoic acid32 42 18	INF	RUNX2, PDGFRA, , CDK4, SDHC, KIT
30	thymidine32 18	INF	RUNX2, PDGFRA, , MDM2, CDK4, KIT
31	phosphatidylinositol32	INF	RUNX2, PDGFRA, , GLI1, MDM2, KIT
32	tyrosine32	INF	RUNX2, PDGFRA, , MDM2, CDK4, S100A1
33	vegf32	INF	RUNX2, PDGFRA, , MDM2, CDK4, SDHC
34	paraffin32	INF	PDGFRA, , HMGA2, MDM2, CDK4, S100A1
35	oxygen32 18	INF	RUNX2, , MDM2, CDK4, SDHD, SDHC
36	ag-129632	INF	KIT, , PDGFRA
37	nitric oxide32 9 18 9	INF	RUNX2, , MDM2, CDK4, S100A1, KIT
38	valine32	INF	, MDM2, CDK4, SERPINA3, KIT
39	alanine32	INF	RUNX2, , MDM2, CDK4
40	leptomycin b32	INF	, MDM2, LPP
41	cycloheximide32	INF	RUNX2, , MDM2, CDK4, KIT
42	lead32	INF	, MDM2, CDK4, KIT
43	calcium32 9 18 9	INF	RUNX2, PDGFRA, , IDH1, MDM2, CDK4
44	progesterone32 42 9 18 9	INF	, MDM2, CDK4, S100A1, SERPINA3, KIT
45	paclitaxel32 34 9 9	INF	KIT, CDK4, MDM2,

Cellular components related to chondroma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:005743	9.2	SDHA, SDHB, SDHC, SDHD, IDH2
2	mitochondrial respiratory chain complex II	GO:005749	9.2	SDHA, SDHB, SDHC, SDHD

Biological processes related to chondroma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	glyoxylate cycle	GO:006097	10.0	IDH1, IDH2
2	isocitrate metabolic process	GO:006102	9.8	IDH2, IDH1
3	succinate metabolic process	GO:006105	9.6	SDHA, SDHB
4	respiratory electron transport chain	GO:022904	9.6	SDHD, SDHC, SDHB, SDHA
5	stem cell differentiation	GO:048863	9.4	KIT, HMGA2
6	positive regulation of phospholipase C activity	GO:010863	9.1	PDGFRA, KIT
7	tricarboxylic acid cycle	GO:006099	9.1	SDHA, SDHB, SDHC, SDHD, IDH1, IDH2
8	positive regulation of cell proliferation	GO:008284	INF	TSPAN31, PDGFRA, , GLI1, MDM2, CDK4

Molecular functions related to chondroma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	isocitrate dehydrogenase (NADP+) activity	GO:004450	9.9	IDH1, IDH2
2	succinate dehydrogenase (ubiquinone) activity	GO:008177	9.8	SDHA, SDHB
3	succinate dehydrogenase activity	GO:000104	9.8	SDHA, SDHC, SDHD
4	ubiquinone binding	GO:048039	9.7	SDHD, SDHB
5	protein binding	GO:005515	5.6	PDGFRA, HMGA2, GLI1, MDM2, CDK4, S100A1