MCID: CHN010
MIFTS: 42

Chondroma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Chondroma

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Aliases & Descriptions for Chondroma:

Name: Chondroma 11 48 50 39 13 68
Central Chondroma 11
 
Chondroma Nos 11
Enchondroma 68

Classifications:



External Ids:

Disease Ontology11 DOID:2602
MeSH39 D002812
NCIt45 C53459

Summaries for Chondroma

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Wikipedia:71 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards based summary: Chondroma, also known as central chondroma, is related to paraganglioma and gastric stromal sarcoma and gastrointestinal stromal tumor, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways are Carbon metabolism and Citrate cycle (TCA cycle). Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are embryo and normal.

Disease Ontology:11 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Related Diseases for Chondroma

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Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma and gastric stromal sarcoma29.4SDHB, SDHC, SDHD
2gastrointestinal stromal tumor29.0ACTC1, SDHB, SDHC, SDHD
3extraskeletal chondroma12.2
4juxtacortical chondroma12.0
5central nervous system chondroma11.8
6dysplasia epiphysealis hemimelica with chondromas and osteochondromas11.7
7phalanx chondroma11.7
8carney triad11.1
9carpotarsal osteochondromatosis10.9
10paragangliomas 1, with or without deafness10.8
11chondroid chordoma10.8
12periostitis10.5
13pelvic lipomatosis10.2HMGA2, SDHB
14catastrophic antiphospholipid syndrome10.2SDHB, SDHD
15acrocapitofemoral dysplasia10.2SDHB, SDHD
16bone ameloblastoma10.2SDHB, SDHD
17temporal lobe neoplasm10.2CTNNB1, HMGA2
18laryngitis10.2
19chondrosarcoma10.1
20intestinal pseudo-obstruction10.1CTNNB1, GLI1
21papillary adenoma10.1HMGA2, SDHB
22paraganglioma10.1
23childhood central nervous system primitive neuroectodermal neoplasm10.1CTNNB1, GLI1
24male urethral cancer10.1ACTC1, CTNNB1
25cervicitis10.1
26house allergic alveolitis10.1ACTC1, HMGA2
27pilar sheath acanthoma10.1ACTC1, HMGA2
28central hypoventilation syndrome, congenital10.1SDHB, SDHD
29neuropathy, congenital, with arthrogryposis multiplex10.0SDHB, SDHC, SDHD
30fitz-hugh-curtis syndrome10.0ACTC1, CTNNB1
31intravenous leiomyomatosis10.0SDHB, SDHC, SDHD
32endocervical adenocarcinoma10.0SDHB, SDHC, SDHD
33glioma susceptibility 210.0SDHB, SDHC, SDHD
34amaurosis congenita, cone-rod type, with congenital hypertrichosis10.0SDHB, SDHC, SDHD
35cardiac arrest10.0SDHB, SDHC, SDHD
36cowden syndrome 310.0SDHB, SDHC, SDHD
37glycogen storage disease ic10.0SDHB, SDHC, SDHD
38non-syndromic male infertility due to sperm motility disorder10.0SDHB, SDHC, SDHD
39neurofibromatosis-noonan syndrome10.0SDHB, SDHC, SDHD
40isolated methylmalonic acidemia10.0SDHB, SDHC, SDHD
41extragonadal germ cell cancer10.0CTNNB1, GLI1
42non-syndromic x-linked intellectual disability10.0SDHB, SDHC, SDHD
43carotenemia10.0SDHB, SDHC, SDHD
44zollinger-ellison syndrome10.0SDHB, SDHC, SDHD
45childhood teratocarcinoma of the testis10.0SDHB, SDHC, SDHD
46erythrocytosis, familial, 210.0SDHB, SDHC, SDHD
47popliteal pterygium syndrome, bartsocas-papas type10.0ACTC1, CTNNB1
48benign shuddering attacks10.0SDHB, SDHC, SDHD
49leiomyosarcoma10.0
50impaired renal function disease10.0PTH1R, SDHB

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Symptoms & Phenotypes for Chondroma

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UMLS symptoms related to Chondroma:


pain

MGI Mouse Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.6CTNNB1, GLI1, MIB1, PTH1R, SDHD
2MP:00028737.7ACTC1, CTNNB1, GLI1, MIB1, SDHB, SDHD
3MP:00107687.2ACTC1, CTNNB1, GLI1, MIB1, PTH1R, SDHB

Drugs & Therapeutics for Chondroma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone SarcomasRecruitingNCT02389244Phase 2
2Low Grade Chondrosarcoma Versus EnchondromaCompletedNCT02996747

Search NIH Clinical Center for Chondroma


Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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MalaCards organs/tissues related to Chondroma:

36
Tongue, Bone, Lung, Spinal cord, Trachea, Breast, Liver

Publications for Chondroma

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Articles related to Chondroma:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Trigger Finger Caused by Extraskeletal Chondroma. (27817941)
2017
2
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. (27185409)
2016
3
Intracranial dural based chondroma. (26602798)
2016
4
Breast Chondroma. (27797122)
2016
5
Scrotal chondroma in a young male: A rare case report. (27166053)
2016
6
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. (27602219)
2016
7
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. (27179652)
2016
8
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. (27461824)
2016
9
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. (27213734)
2016
10
Case report of chondroma in a grass carp (Ctenopharyngodon idella). (27482364)
2016
11
A case of chondroma cutis showing callus-like appearance. (26932734)
2016
12
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? (27026930)
2016
13
Intradural chondroma in the cervical spine: case report. (27740393)
2016
14
Periosteal chondroma of the femur: A case report and review of the literature. (25789014)
2015
15
Orbital Chondroma: A rare mesenchymal tumor of orbit. (26265654)
2015
16
Chondroma of Cerebral Falx: A Rare Intracranial Diagnosis. (26454394)
2015
17
Extraskeletal Chondroma in the Popliteal Region: A Case Report. (26960310)
2015
18
A rare case of bladder chondroma. (25844100)
2015
19
Novel Pathologic Finding of Digital Soft Tissue Chondroma in a Child: A Case Report and Review of Literature. (26113665)
2015
20
Extraosseous chondroma of anterior neck in pediatric patient. (26104481)
2015
21
Primary spinal extraosseous cervical chondroma in an adult. (25751486)
2015
22
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. (26091072)
2015
23
Periosteal chondroma of the distal tibia: Computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. (26137286)
2015
24
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. (26918096)
2015
25
Nasal chondroma presenting as hypertelorism. (25730333)
2015
26
Endobronchial chondroma: An unusual case of bronchial obstruction. (25770939)
2015
27
Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review. (26834817)
2015
28
Bilateral extraskeletal chondroma of the neck. (26381679)
2015
29
Soft tissue chondroma presenting as a dermal mass in the toe. (26015904)
2015
30
Extensive Periosteal Chondroma in the Middle Phalanx with Pathological Fracture Reconstructed with Strut Bone Grafting. (26051780)
2015
31
Extraskeletal Chondroma of the Gluteal Region Along with Sporadic Neurofibroma - An Unusual Presentation. (26155485)
2015
32
True cutaneous chondroma: a case report. (25998426)
2015
33
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. (26156668)
2015
34
Chondroma of the falx cerebri. (25909200)
2015
35
Arytenoid cartilage chondroma. (25960446)
2015
36
Chondroma of the scalp. (26405500)
2015
37
Chondroblastoma-like chondroma of the hand: case report. (24656394)
2014
38
An uncommon cause of anterior knee pain: patellar chondroma. (23669736)
2014
39
Falx chondroma with hyperostosis of the scull: a case report. (25233692)
2014
40
Imaging features of periosteal chondroma manifesting as a subcutaneous mass in the index finger. (24778891)
2014
41
A rare case of chondroma of falx cerebri. (25269052)
2014
42
Chondroma of the diaphragm mimicking a giant liver tumor with calcification: report of a case. (24931544)
2014
43
Arytenoid cartilage chondroma. (25181657)
2014
44
Focal periosteal chondroma of the hand: a review of 24 cases. (25172018)
2014
45
Convexity dural chondroma: a case report with pathological and molecular analysis. (25250651)
2014
46
Intracranial extra-axial chondroma: a case report. (24614393)
2014
47
A rare case of chondroma of the parotid gland. (24868998)
2014
48
A rare case of giant soft tissue chondroma of the wrist: A cytopathological study with review of the literature. (25190983)
2014
49
Extraskeletal chondroma of the foot-a case report. (24783107)
2014
50
Imaging features of juxtacortical chondroma in children. (23955368)
2014

Variations for Chondroma

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Expression for genes affiliated with Chondroma

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Search GEO for disease gene expression data for Chondroma.

GO Terms for genes affiliated with Chondroma

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Cellular components related to Chondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)GO:00057499.9SDHB, SDHC, SDHD
2respiratory chain complex IIGO:00452739.8SDHB, SDHC
3protein-DNA complexGO:00329939.5CTNNB1, HMGA2

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1aerobic respirationGO:000906010.5SDHB, SDHC
2epithelial to mesenchymal transitionGO:000183710.3CTNNB1, HMGA2
3epithelial tube branching involved in lung morphogenesisGO:006044110.3CTNNB1, HMGA2
4pituitary gland developmentGO:002198310.2GLI1, HMGA2
5dorsal/ventral pattern formationGO:000995310.2CTNNB1, GLI1
6chondrocyte differentiationGO:00020629.9HMGA2, PTH1R
7proximal/distal pattern formationGO:00099549.9CTNNB1, GLI1
8bone resorptionGO:00454539.9CTNNB1, PTH1R
9cell maturationGO:00484699.9CTNNB1, PTH1R
10regulation of osteoblast differentiationGO:00456679.9CTNNB1, GLI1
11positive regulation of gene expressionGO:00106289.5ACTC1, CTNNB1, HMGA2
12tricarboxylic acid cycleGO:00060999.4SDHB, SDHC, SDHD
13positive regulation of cell proliferationGO:00082848.9CTNNB1, GLI1, HMGA2, PTH1R

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:000817710.0SDHB, SDHD
2succinate dehydrogenase activityGO:00001049.9SDHC, SDHD
3electron carrier activityGO:00090559.9SDHB, SDHC, SDHD
4SMAD bindingGO:00463329.9CTNNB1, HMGA2
5ubiquinone bindingGO:00480399.8SDHB, SDHD

Sources for Chondroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet