MCID: CHN010
MIFTS: 55

Chondroma malady

Summaries for Chondroma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards: Chondroma, also known as central chondroma, is related to chondrosarcoma and paraganglioma. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Pyruvate metabolism. The compounds cycloheximide and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

chondroma 8 42 10 44 60
central chondroma 8
chondroma nos 8


External Ids:

Disease Ontology8 DOID:2602
NCIt39 C53459
MeSH34 D002812

Related Diseases for Chondroma

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17GeneCards, 18GeneDecks
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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.6SERPINA3, PTHLH, HMGA2, CDK4, MDM2, PDGFRA
2paraganglioma30.6IDH2, S100A1, KIT, SDHD, SDHB, SDHC
3leiomyosarcoma30.4KIT, CDK4, MDM2, PDGFRA, S100A1
4chondroblastoma30.0PTHLH
5meningioma30.0S100A1
6chordoma30.0PDGFRA, S100A1
7sarcoma30.0S100A1, PDGFRA, MDM2, HMGA2, KIT, CDK4
8pituitary adenoma29.8HMGA2, CDK4
9glomus tumor29.8SDHB, SDHD, S100A1
10fibrosarcoma29.8PDGFRA, MDM2
11gastrointestinal stromal tumor29.8PDGFRA, KIT
12adenoma29.8HMGA2, CDK4, CTNNB1, S100A1
13carney triad29.8SDHC, SDHB, SDHD, KIT, PDGFRA
14leiomyoma29.8S100A1, PDGFRA, KIT, HMGA2
15astrocytoma29.8IDH1, PDGFRA, MDM2, CDK4, SERPINA3
16lipoma29.7HMGA2, CDK4, LPP, MDM2, S100A1, LHFP
17squamous cell carcinoma29.7S100A1, PDGFRA, CTNNB1, MDM2, GLI1, CDK4
18periostitis10.8
19extraskeletal chondroma10.6
20juxtacortical chondroma10.5
21laryngitis10.5
22cervicitis10.3
23gastric leiomyosarcoma10.2
24meningitis10.2
25periosteal chondrosarcoma10.2
26central nervous system chondroma10.1
27asthma10.1
28radiculopathy10.0
29carpal tunnel syndrome10.0
30epithelioid leiomyosarcoma10.0
31mesenchymal chondrosarcoma10.0
32carpotarsal osteochondromatosis10.0
33ollier disease10.0PTHLH
34gliosarcoma10.0CDK4
35arthritis10.0SERPINA3
36dermatofibrosarcoma10.0MDM2
37basal cell carcinoma10.0GLI1
38renal oncocytoma10.0S100A1
39seminal vesicle tumor10.0SDHA
40cervical cancer10.0MDM2
41acute leukemia10.0KIT
42pheochromocytoma10.0SDHD, SDHB
43craniopharyngioma10.0CTNNB1
44uterine carcinosarcoma10.0KIT
45hereditary paraganglioma-pheochromocytoma syndromes10.0SDHD, SDHB, SDHC
46von hippel-lindau disease10.0SDHC, SDHB, SDHD
47hemangioma10.0SDHC, SDHB, SDHD
48paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
49carotid body tumor10.0SDHD, SDHB, SDHC
50thymus cancer10.0KIT

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Clinical Features for Chondroma

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Drugs & Therapeutics for Chondroma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chondroma

Drug clinical trials:

Search ClinicalTrials for Chondroma

Search NIH Clinical Center for Chondroma

Search CenterWatch for Chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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32MalaCards
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MalaCards organs/tissues related to Chondroma:

32
Tongue, Bone, Lung, Cortex, Spinal cord, Trachea, Occipital lobe, Testis, Prostate, Breast, Thyroid, Liver, Heart, Pituitary

Animal Models for Chondroma or affiliated genes

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36MGI
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Publications for Chondroma

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50PubMed
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Articles related to Chondroma:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Subungual Soft Tissue Chondroma with Nail Deformity in a Child. (23869595)
2013
2
Soft tissue chondroma mimicking "dumbbell" neurogenic tumour: A rare cause of lumbar radiculopathy. (24380757)
2013
3
A large extraskeletal chondroma in the hand of an elderly patient--a case report. (23413864)
2013
4
A case of bilateral multiple pulmonary chondroma: necessity of follow-up for Carney's triad. (22664948)
2012
5
Extremely rare case of primary cardiac chondroma in a patient presenting with acute pulmonary edema. (20889354)
2011
6
Extraskeletal chondroma: another diagnostic possibility for a soft tissue axillary mass in an adolescent. (23198206)
2011
7
Childhood soft tissue chondroma. Two cases report. (21484690)
2011
8
An intracranial chondroma with intratumoral and subarachnoidal hemorrhage. (21483150)
2011
9
Extraskeletal chondroma in the auricle. (21119479)
2010
10
Multiple pulmonary chondromas in a young female patient: a component of Carney triad. (19461402)
2009
11
Unilateral mosaic cutaneous vascular lesions, enchondroma, multiple soft tissue chondromas and congenital fibrosarcoma--a variant of Maffucci syndrome? (18429781)
2008
12
Bizarre parosteal osteochondromatous proliferation and periosteal chondroma: a comparative report and review of the literature. (17606073)
2007
13
Concurrent periosteal chondroma and enchondroma of the fibula mimicking chondrosarcoma. (16421751)
2006
14
Posterior interosseous neuropathy due to compression by a soft tissue chondroma of the elbow. (16076062)
2005
15
Juxtacortical chondroma of the hand: treatment by resection of the tumour and the adjacent bone cortex. (15935532)
2005
16
Anterior septal chondroma. (23120105)
2004
17
Laryngeal chondroma: a rare neck tumor in pediatric age. (15533570)
2004
18
Soft-tissue chondroma in a finger: a case report. (12152379)
2002
19
Extraskeletal chondroma of the fallopian tube. (11961319)
2002
20
Extraskeletal chondroma around the knee. (11585403)
2001
21
Intracapsular and para-articular chondroma adjacent to large joints: report of three cases and review of the literature. (11810164)
2001
22
Posterior fossa chondroma arising from the tentorium: a case report. (10660027)
1999
23
Condylar chondroma: report of a case. (9496853)
1998
24
Intracranial chondroma of the occipital lobe. (9509611)
1998
25
Childhood soft tissue chondroma: a case report. (8597830)
1995
26
Extraskeletal chondroma with chondroblastic and granuloma-like elements. (7634679)
1995
27
Image interpretation session. Intrasellar chondroma. (1996389)
1991
28
Trigger finger secondary to soft tissue chondroma. (2269840)
1990
29
Recurrence and malignant transformation of endotracheal chondroma. (2339945)
1990
30
Tracheal chondroma: CT appearance. (3183122)
1988
31
Bilateral chondroma of the auricle. (3351074)
1988
32
Chondroma of the nasal cavity and nasopharynx--a case of chondroma arising from the nasal septum. (3449038)
1987
33
Extra-adrenal paraganglioma and pulmonary chondroma: a case report and review of the literature. (2884350)
1987
34
Chondroma of the tongue. (3456027)
1986
35
Extraadrenal paraganglioma, pulmonary chondroma, and gastric leiomyoblastoma: triad in young females. (106655)
1979
36
Prolonged survival following excision of dural chondroma. (619012)
1978
37
Odontogenic keratocyst associated with an intramandibular chondroma. (264262)
1977
38
Intracranial chondroma. (898003)
1977
39
Periosteal chondroma. Report of two cases with atypical radiological features. (993246)
1976
40
Chondroma of the tongue. (5267622)
1970
41
Chondroma of the bronchus. (5810373)
1969
42
Case reports and technical notes. Chondroma of the cervical spine. Case report. (5684408)
1968
43
AN EXCEPTIONALLY LARGE CHONDROMA OF THE MAXILLA: CASE REPORT. (14256819)
1965
44
Endobronchial chondroma as a trigger mechanism in asthma. Report of a case with endobronchial extirpation of chondroma. (14453351)
1962
45
Laryngeal chondroma. (13715797)
1961
46
Solitary chondroma of the right main bronchus. (13724192)
1960
47
Laryngeal chondroma. (13775120)
1960
48
A case of chondroma of the nasopharynx. (13332362)
1956
49
The central malignant chondroma of bone. (14778069)
1950
50
Chondroma of right knee]. (20280022)
1947

Genetic Variations for Chondroma

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Expression for genes affiliated with Chondroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Chondroma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5RUNX2
2fumarate44 1111.2SDHC, SDHB, SDHD
3UBIQUINONE-11110.0SDHB, SDHC, SDHD, SDHA
42-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHA, SDHC, SDHB, SDHD
5isocitrate4410.0IDH1, IDH2, SDHB
6succinic acid28 11 2412.0SDHA, SDHC, SDHB, SDHD
7iron-sulfur4410.0SDHB, SDHD, SDHC, SDHA
8ubiquinone4410.0SDHB, SDHA, SDHC, SDHD
9naphthol as-d chloroacetate4410.0KIT, SERPINA3
10succinate4410.0SDHD, SDHB, SDHA, SDHC
11Isocitric Acid11 2411.0IDH1, IDH2
12ag-1296449.8PTHLH, PDGFRA, KIT
13somatropin recombinant49 1110.7CDK4, TSPAN31
14paclitaxel44 49 1111.6CDK4, MDM2, CTNNB1
15lead449.5PTHLH, CDK4, MDM2, KIT
16dexamethasone44 49 28 1112.5MDM2, CTNNB1, CDK4
17glucose449.5SDHB, RUNX2, GLI1, PTHLH, SERPINA3
18glyceraldehyde 3-phosphate449.5MDM2, IDH1, SDHA, SDHB
19valine449.4MDM2, KIT, PTHLH, SERPINA3, CDK4
20roscovitine449.4CDK4, CTNNB1, RUNX2, MDM2
21leptomycin b44 5910.3CTNNB1, LPP, PTHLH, MDM2
22trastuzumab44 49 1111.3CTNNB1, MDM2, CDK4, KIT
23steroid449.3CDK4, PTHLH, SERPINA3, SDHC, RUNX2, MDM2
24gefitinib44 49 1111.3MDM2, KIT, CDK4, CTNNB1
25geldanamycin44 49 59 1112.3KIT, CDK4, MDM2, CTNNB1
26tgf beta1449.1CDK4, PTHLH, CTNNB1, PDGFRA, RUNX2
27imatinib44 49 1111.1CTNNB1, PDGFRA, KIT, MDM2
28doxorubicin44 49 1111.0CTNNB1, KIT, CDK4, MDM2, HMGA2
29arginine448.9SERPINA3, MDM2, CDK4, PTHLH, CTNNB1, SDHB
30rapamycin448.9CDK4, KIT, PDGFRA, CTNNB1, MDM2
31testosterone44 59 11 2411.8KIT, CDK4, CTNNB1, MDM2, PTHLH, SDHB
32pd 98,059448.7MDM2, GLI1, CDK4, CTNNB1, KIT, RUNX2
33alanine448.7RUNX2, PTHLH, SDHB, SERPINA3, CDK4, MDM2
34oxygen44 249.6SDHD, RUNX2, CDK4, PTHLH, SDHC, SDHA
35cisplatin44 49 59 1111.6PTHLH, CTNNB1, MDM2, CDK4, HMGA2
36thymidine44 249.4KIT, CDK4, MDM2, CTNNB1, PDGFRA, RUNX2
37iron44 249.4CDK4, SDHA, SDHC, SDHB, SDHD, S100A1
38threonine448.4CDK4, KIT, SERPINA3, MDM2, CTNNB1, PTHLH
39zinc44 249.4SDHB, RUNX2, S100A1, MDM2, GLI1, CDK4
40oligonucleotide448.4SERPINA3, MDM2, CTNNB1, KIT, PDGFRA, RUNX2
41phosphatidylinositol448.1KIT, GLI1, MDM2, CTNNB1, PDGFRA, RUNX2
42glycogen44 249.1MDM2, CTNNB1, S100A1, PTHLH, CDK4, KIT
43progesterone44 59 28 11 2412.1MDM2, CTNNB1, KIT, CDK4, SERPINA3, S100A1
44nitric oxide44 11 2410.0KIT, PTHLH, S100A1, RUNX2, CDK4, MDM2
45vegf448.0PDGFRA, RUNX2, CDK4, KIT, PTHLH, SDHB
46cysteine447.9CTNNB1, MDM2, S100A1, CDK4, KIT, SERPINA3
47paraffin447.5CTNNB1, PDGFRA, S100A1, KIT, MDM2, CDK4
48calcium44 49 11 2410.3MDM2, KIT, PDGFRA, S100A1, RUNX2, CDK4
49retinoic acid44 248.3S100A1, PDGFRA, SDHC, SERPINA3, PTHLH, HMGA2
50tyrosine447.3CTNNB1, PTHLH, SDHB, KIT, CDK4, MDM2

GO Terms for genes affiliated with Chondroma

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16Gene Ontology
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Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7HMGA2, CTNNB1
2mitochondrial respiratory chain complex IIGO:0057499.6SDHA, SDHC, SDHB, SDHD
3mitochondrial inner membraneGO:0057439.2IDH2, SDHD, SDHB, SDHC, SDHA
4nucleusGO:0056345.7RUNX2, S100A1, PDGFRA, CTNNB1, MDM2, LPP

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.1IDH1, IDH2
2isocitrate metabolic processGO:00610210.0IDH2, IDH1
3respiratory electron transport chainGO:0229049.7SDHA, SDHC, SDHB, SDHD
4negative regulation of chondrocyte differentiationGO:0323319.7PTHLH, CTNNB1
5stem cell differentiationGO:0488639.7RUNX2, KIT, HMGA2
6succinate metabolic processGO:0061059.7SDHA, SDHB
7positive regulation of phospholipase C activityGO:0108639.6KIT, PDGFRA
8cellular metabolic processGO:0442379.5IDH2, SDHD, SDHB, SDHC, SDHA
9tricarboxylic acid cycleGO:0060999.3SDHA, IDH1, IDH2, SDHD, SDHB, SDHC
10odontogenesis of dentin-containing toothGO:0424759.2RUNX2, PDGFRA, CTNNB1
11positive regulation of cell proliferationGO:0082847.9RUNX2, PDGFRA, MDM2, GLI1, CDK4, KIT

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
2succinate dehydrogenase (ubiquinone) activityGO:0081779.9SDHA, SDHB
3ubiquinone bindingGO:0480399.8SDHB, SDHD
4protein bindingGO:0055155.8LPP, MDM2, CTNNB1, PDGFRA, S100A1, GLI1

Products for genes affiliated with Chondroma

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Sources for Chondroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet