MCID: CHN010
MIFTS: 50

Chondroma malady

Rare diseases category

Summaries for Chondroma

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Wikipedia:63 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards based summary: Chondroma, also known as central chondroma, is related to paraganglioma and carney triad. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Glucose / Energy Metabolism and Alzheimer's disease. The compounds Oxalosuccinic acid and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:9 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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Chondroma, Aliases & Descriptions:

Name: Chondroma 9 41 11 43 60
Central Chondroma 9
 
Chondroma Nos 9
Enchondroma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:2602
MeSH33 D002812
NCIt38 C53459

Related Diseases for Chondroma

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Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma30.7SDHB, SDHD, SDHC, SDHA, S100A1, IDH2
2carney triad30.7SDHC, SDHD, PDGFRA, SDHB
3leiomyosarcoma30.5S100A1, MDM2, PDGFRA, CDK4
4paraganglioma and gastric stromal sarcoma30.5SDHD, SDHC, SDHB
5paragangliomas 1, with or without deafness30.5SDHC, SDHB, SDHD
6glomus tumor30.4SDHB, SDHD, S100A1
7chordoma30.4PDGFRA, S100A1
8leiomyoma30.2PDGFRA, HMGA2, S100A1
9chondrosarcoma30.1SERPINA3, MDM2, PDGFRA, HMGA2, CDK4, RUNX2
10gastrointestinal stromal tumor29.9PDGFRA, SDHA, SDHC, S100A1, SDHB
11sarcoma29.8PDGFRA, CDK4, MDM2, GLI1, S100A1, HMGA2
12astrocytoma29.7MDM2, CDK4, IDH1, PDGFRA, SERPINA3
13adenoma29.5CDK4, HMGA2, CTNNB1, S100A1
14lipoma29.3MDM2, S100A1, HMGA2, LHFP, CDK4, LPP
15periostitis10.8
16extraskeletal chondroma10.7
17juxtacortical chondroma10.6
18laryngitis10.5
19paragangliomas 510.5SDHA
20gliosarcoma10.5CDK4
21lipomatosis10.5HMGA2
22pleomorphic adenoma10.5HMGA2
23pheochromocytoma10.4SDHD, SDHB
24cervicitis10.4
25neurofibromatosis, type 210.4SDHD, SDHB
26hereditary paraganglioma-pheochromocytoma syndromes10.4SDHC, SDHB, SDHD
27giant cell glioblastoma10.4MDM2
28phaeochromocytoma10.4SDHB, SDHC, SDHD
29interval angle-closure glaucoma10.4IDH1, IDH2
30multiple endocrine neoplasia iia10.4SDHB, SDHD, SDHC
31von hippel-lindau syndrome10.4SDHB, SDHD, SDHC
32multiple endocrine neoplasia10.4SDHC, SDHD, SDHB
33multiple endocrine neoplasia 110.4SDHC, SDHB, SDHD
34d-2-hydroxyglutaric aciduria10.4IDH1, IDH2
35hyperparathyroidism10.4SDHB, SDHD, SDHC
36intraductal papilloma10.4IDH2, IDH1
37hemangioma10.4SDHB, SDHD, SDHC
38neurofibroma10.3PDGFRA, S100A1
39connective tissue benign neoplasm10.3MDM2, CDK4
40hemangiopericytoma10.3MDM2, S100A1
41central nervous system chondroma10.3
42meningitis10.3
43osteochondroma10.3
44myxoid liposarcoma10.3MDM2, CDK4
45rhabdomyosarcoma 2, alveolar10.3CDK4, MDM2
46ameloblastoma10.2SERPINA3, GLI1
47dedifferentiated liposarcoma10.2CDK4, HMGA2, MDM2
48smooth muscle tumor10.2S100A1, HMGA2
49asthma10.2
50chondroblastoma10.2

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Symptoms for Chondroma

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Drugs & Therapeutics for Chondroma

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Drug clinical trials:

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Search NIH Clinical Center for Chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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MalaCards organs/tissues related to Chondroma:

31
Tongue, Bone, Lung, Cortex, Spinal cord, Liver, Trachea, Heart, Thyroid, Breast, Prostate, Testis, Occipital lobe, Pituitary

Animal Models for Chondroma or affiliated genes

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MGI Mouse Phenotypes related to Chondroma:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
2MP:00053718.7RUNX2, PDGFRA, HMGA2, GLI1, MDM2, CTNNB1
3MP:00030128.6RUNX2, SDHB, PDGFRA, GLI1, MDM2, CTNNB1
4MP:00053678.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA
5MP:00053818.5RUNX2, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
6MP:00053808.5SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
7MP:00053828.5RUNX2, PDGFRA, HMGA2, MDM2, CTNNB1
8MP:00053798.5RUNX2, SDHD, PDGFRA, HMGA2, GLI1, CDK4
9MP:00107718.4RUNX2, PDGFRA, HMGA2, MDM2, CDK4, CTNNB1
10MP:00053698.2RUNX2, PDGFRA, S100A1, MDM2, CDK4, CTNNB1
11MP:00036318.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
12MP:00053858.0RUNX2, SDHD, PDGFRA, S100A1, MDM2, CDK4
13MP:00053788.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
14MP:00053868.0SDHD, PDGFRA, S100A1, HMGA2, GLI1, MDM2
15MP:00028737.9SDHD, PDGFRA, S100A1, GLI1, MDM2, CTNNB1
16MP:00053897.7CTNNB1, RUNX2, LPP, PDGFRA, HMGA2, GLI1
17MP:00053847.7RUNX2, SDHD, LPP, PDGFRA, GLI1, MDM2
18MP:00053767.5RUNX2, IDH1, SDHD, LPP, PDGFRA, HMGA2
19MP:00107687.4RUNX2, SDHD, SDHC, LPP, PDGFRA, GLI1

Publications for Chondroma

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Articles related to Chondroma:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
A rare case of bladder chondroma. (25844100)
2015
2
True chondroma of the mandibular condyle: A rare case. (25593880)
2014
3
Intracranial extra-axial chondroma: a case report. (24614393)
2014
4
Chondroma located in cerebral parenchyma without meningeal attachment. (23172440)
2012
5
Extraskeletal chondroma in the auricle. (21119479)
2010
6
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
7
Massive chondroma of pelvis - case report. (19828919)
2009
8
Atypical location of a solitary intracranial chondroma without meningeal attachment. (17614089)
2007
9
Cutaneous chondroma with overlying pigmentation clinically mimicking dermatofibroma. (16403116)
2006
10
Intracortical chondroma: a report of two cases. (16284766)
2006
11
Nasal septum chondroma: a case report. (15875440)
2005
12
Laparoscopic presentation of a rib chondroma. (14676003)
2004
13
Soft-tissue chondroma in a finger: a case report. (12152379)
2002
14
Soft-tissue chondroma in the thumb. (12409791)
2002
15
Periosteal chondroma presenting as a subcutaneous mass in the thumb. (11733159)
2001
16
DNA flow cytometric analysis of chest-wall chondroma and chondrosarcoma. (8976036)
1996
17
Extraskeletal chondroma of the foot. (8867554)
1996
18
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. (7785598)
1995
19
Soft tissue chondroma of the fallopian tube. Differential diagnosis and histogenetic considerations. (7567687)
1995
20
Cardiac valvular chondroma. (7979695)
1994
21
Skull base chondroma of extracranial origin. (7822182)
1994
22
Soft-tissue chondroma as a cause of calcinosis in a patient with CREST syndrome. (8457459)
1993
23
Chondroma of the cervical spinal canal. Case report. (1306207)
1992
24
Benign cartilaginous tumor (chondroma) of the liver. (1634084)
1992
25
Intra-tendinous chondroma of a flexor tendon. (1779169)
1991
26
Chondroma of the lumbar spine, a rare cause of sciatica: case report. (2330093)
1990
27
Ossifying parasellar chondroma. Case report. (3117983)
1987
28
Chondroma of the nasal cavity and nasopharynx--a case of chondroma arising from the nasal septum. (3449038)
1987
29
Chondroma of falx: CT findings. (3782554)
1986
30
Case report 354: Chondroma of soft tissues with dystrophic calcification. (3961527)
1986
31
Extraskeletal ossifying chondroma in the knee. A case report. (3984711)
1985
32
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984
33
Malignant chondroma. (6582165)
1983
34
Orbital chondroma rodens in a dog. (500440)
1979
35
Intracerebral chondroma. (483149)
1979
36
The nasal chondroma. 2 case reports and a survey of the literature. (864317)
1977
37
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. 3. Cartilaginous tumors (chondroma, chondrosarcoma). (4853358)
1974
38
Periosteal chondroma. (4506239)
1972
39
Intracranial solitary chondroma of dural origin. (5459528)
1970
40
Case reports and technical notes. Chondroma of the cervical spine. Case report. (5684408)
1968
41
Chondroma of sternum. A case report. (14441200)
1959
42
Chondroma of the larynx; report of a case with recurrence after twenty-eight years. (13636589)
1959
43
An endobronchial chondroma in a cachectic psychotic with hypopituitarism. (13253916)
1955
44
Chondroma of the vocal cord. (15412306)
1950
45
Chondroma of the larynx; report of a case. (15393512)
1949
46
Laryngeal chondroma. (18892972)
1948
47
Chondroma of the larynx; report of a case. (18921039)
1948
48
Chondroma of right knee]. (20280022)
1947
49
Chondroma of eighth costal cartilage]. (21001781)
1946
50
Osteofibro-chondroma of the scapula in a new born infant. (20275903)
1946

Variations for Chondroma

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Expression for genes affiliated with Chondroma

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Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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Pathways related to Chondroma according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SDHA, IDH1, IDH2
2
Show member pathways
Alzheimers Disease36
9.5SDHA, SDHC, SDHD, SDHB
39.5MDM2, HMGA2, RUNX2
49.4CDK4, MDM2, PDGFRA
59.3MDM2, CDK4, CTNNB1
69.3CTNNB1, CDK4, MDM2
79.3RUNX2, CDK4, CTNNB1
8
Show member pathways
9.3IDH2, SDHB, SDHD, SDHC, SDHA
99.2CTNNB1, MDM2, RUNX2
10
Show member pathways
9.2PDGFRA, MDM2, CTNNB1
11
Show member pathways
TCA cycle36
pyruvate decarboxylation to acetyl CoA36
NAD phosphorylation and dephosphorylation36
TCA Cycle36
conversion of glucose to acetyl CoA and entry into the TCA cycle36
9.0SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
12
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.0IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
13
Show member pathways
Signaling Pathways in Glioblastoma36
8.9PDGFRA, MDM2, CDK4, CTNNB1
148.9CTNNB1, CDK4, MDM2, PDGFRA
158.9CTNNB1, CDK4, MDM2, PDGFRA
168.6PDGFRA, GLI1, MDM2, CDK4, CTNNB1

Compounds for genes affiliated with Chondroma

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Compounds related to Chondroma according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid2410.3IDH1, IDH2
2fumarate43 1211.2SDHC, SDHD, SDHB
3thenoyltrifluoroacetone43 1211.2SDHB, SDHA
4Isocitric acid24 1211.2IDH2, IDH1
5isocitrate4310.1IDH2, IDH1, SDHB
6Fumaric acid2410.0SDHB, SDHD, SDHC, SDHA
7succinic acid28 24 1212.0SDHB, SDHD, SDHC, SDHA
8iron-sulfur4310.0SDHB, SDHD, SDHC, SDHA
9ubiquinone4310.0SDHB, SDHD, SDHC, SDHA
10Sulfide2410.0SDHB, SDHD, SDHC, SDHA
11QH2249.9SDHB, SDHD, SDHC, SDHA
12Ubiquinone Q2249.9SDHA, SDHC, SDHD, SDHB
13Ubiquinone Q1249.9SDHB, SDHD, SDHC, SDHA
14succinate439.9SDHB, SDHD, SDHC, SDHA
15FAD249.9SDHA, SDHC, SDHD, SDHB
16cyclopamine43 5910.7CTNNB1, GLI1
17nad+439.7SDHB, SDHA, MDM2
18glyceraldehyde 3-phosphate439.7IDH1, SDHB, SDHA, MDM2
19somatropin recombinant49 1210.6TSPAN31, CDK4
20trastuzumab43 49 1211.6CTNNB1, CDK4, MDM2
21gefitinib43 49 1211.5CTNNB1, CDK4, MDM2
22adpribose439.5CTNNB1, CDK4, MDM2
23geldanamycin43 49 59 1212.4CTNNB1, CDK4, MDM2
24roscovitine439.3CTNNB1, CDK4, MDM2, RUNX2
25leptomycin b43 5910.3LPP, MDM2, CTNNB1
26valproic acid43 49 24 1212.3CTNNB1, CDK4, RUNX2
27tgf beta1439.2RUNX2, PDGFRA, CDK4, CTNNB1
28rapamycin439.1PDGFRA, MDM2, CDK4, CTNNB1
29ly294002439.1RUNX2, MDM2, CDK4, CTNNB1
30pd 98,059439.1RUNX2, GLI1, MDM2, CDK4, CTNNB1
31doxorubicin43 49 1210.9CTNNB1, CDK4, MDM2, HMGA2
32glycogen43 249.9SDHB, S100A1, MDM2, CDK4, CTNNB1
33dexamethasone43 49 28 1211.9RUNX2, SERPINA3, MDM2, CDK4, CTNNB1
34steroid438.9RUNX2, SDHC, SERPINA3, MDM2, CDK4, CTNNB1
35thymidine43 249.9RUNX2, PDGFRA, MDM2, CDK4, CTNNB1
36progesterone43 28 59 24 1212.8CTNNB1, CDK4, MDM2, S100A1, SERPINA3
37alanine438.8RUNX2, SDHB, SERPINA3, MDM2, CDK4, CTNNB1
38oxygen43 249.7RUNX2, SDHB, SDHD, SDHC, SDHA, SERPINA3
39oligonucleotide438.7RUNX2, SERPINA3, PDGFRA, MDM2, CDK4, CTNNB1
40cysteine438.7SDHB, SERPINA3, S100A1, MDM2, CDK4, CTNNB1
41zinc43 249.6RUNX2, SDHB, SERPINA3, S100A1, GLI1, MDM2
42phosphatidylinositol438.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA, RUNX2
43iron43 249.6CDK4, SDHB, SDHD, SDHC, SDHA, SERPINA3
44arginine438.6SDHB, SERPINA3, MDM2, CDK4, CTNNB1
45vegf438.5RUNX2, SDHB, SDHC, PDGFRA, MDM2, CDK4
46paraffin438.4SERPINA3, PDGFRA, S100A1, HMGA2, MDM2, CDK4
47estrogen438.2RUNX2, SERPINA3, PDGFRA, S100A1, MDM2, CDK4
48calcium43 49 24 1211.1RUNX2, IDH1, SDHB, SERPINA3, PDGFRA, S100A1
49retinoic acid43 249.1RUNX2, SDHC, SERPINA3, PDGFRA, S100A1, HMGA2
50tyrosine438.0RUNX2, SDHB, PDGFRA, S100A1, MDM2, CDK4

GO Terms for genes affiliated with Chondroma

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Cellular components related to Chondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:00329939.7CTNNB1, HMGA2
2mitochondrial respiratory chain complex IIGO:00057499.6SDHA, SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:00057439.3IDH2, SDHB, SDHD, SDHC, SDHA
4mitochondrionGO:00057398.9IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
5nucleusGO:00056346.4RUNX2, SERPINA3, LPP, PDGFRA, S100A1, HMGA2

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:000609710.2IDH1, IDH2
2succinate metabolic processGO:000610510.2SDHA, SDHB
3isocitrate metabolic processGO:000610210.2IDH2, IDH1
4aerobic respirationGO:000906010.2SDHB, SDHC
52-oxoglutarate metabolic processGO:000610310.2IDH1, IDH2
6stem cell differentiationGO:004886310.1RUNX2, HMGA2
7negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
8adrenal gland developmentGO:00303259.9HMGA2, PDGFRA
9respiratory electron transport chainGO:00229049.8SDHB, SDHD, SDHC, SDHA
10proximal/distal pattern formationGO:00099549.8CTNNB1, GLI1
11male genitalia developmentGO:00305399.7CTNNB1, PDGFRA
12pituitary gland developmentGO:00219839.7HMGA2, GLI1
13embryonic cranial skeleton morphogenesisGO:00487019.6PDGFRA, RUNX2
14cellular metabolic processGO:00442379.6IDH2, SDHB, SDHD, SDHC, SDHA
15odontogenesis of dentin-containing toothGO:00424759.5CTNNB1, PDGFRA, RUNX2
16tricarboxylic acid cycleGO:00060999.3SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
17small molecule metabolic processGO:00442819.2IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
18negative regulation of transcription, DNA-templatedGO:00458929.2CTNNB1, MDM2, HMGA2, RUNX2
19positive regulation of transcription, DNA-templatedGO:00458939.1RUNX2, HMGA2, GLI1, CTNNB1
20negative regulation of transcription from RNA polymerase II promoterGO:00001228.8CTNNB1, MDM2, HMGA2, S100A1
21positive regulation of cell proliferationGO:00082848.3RUNX2, TSPAN31, PDGFRA, GLI1, MDM2, CDK4

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:000817710.1SDHB, SDHA
2isocitrate dehydrogenase (NADP+) activityGO:000445010.0IDH2, IDH1
3ubiquinone bindingGO:004803910.0SDHB, SDHD
4succinate dehydrogenase activityGO:00001049.9SDHA, SDHC, SDHD
5repressing transcription factor bindingGO:00704919.6CTNNB1, RUNX2
6electron carrier activityGO:00090559.5SDHC, SDHD, SDHB
7protein bindingGO:00055156.1RUNX2, SDHB, SDHA, SERPINA3, LPP, PDGFRA

Products for genes affiliated with Chondroma

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Sources for Chondroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet