MCID: CHN010
MIFTS: 59

Chondroma malady

Rare diseases, Cancer diseases categories
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Summaries for Chondroma

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Wikipedia:65 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards based summary: Chondroma, also known as central chondroma, is related to paraganglioma and carney triad. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Glucose / Energy Metabolism and Alzheimer's disease. The compounds Oxalosuccinic acid and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:8 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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Chondroma, Aliases & Descriptions:

Name: Chondroma 8 42 10 44 62
Central Chondroma 8 62
 
Chondroma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


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Disease Ontology8 DOID:2602
MeSH34 D002812
NCIt39 C53459

Related Diseases for Chondroma

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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma31.3SDHB, SDHD, S100A1
2carney triad30.7SDHC, SDHD, PDGFRA, SDHB
3leiomyosarcoma30.5S100A1, MDM2, PDGFRA, CDK4
4paraganglioma and gastric stromal sarcoma30.5SDHD, SDHC, SDHB
5chordoma30.4PDGFRA, S100A1
6leiomyoma30.2PDGFRA, HMGA2, S100A1
7chondrosarcoma30.2SERPINA3, MDM2, PDGFRA, HMGA2, CDK4, RUNX2
8gastrointestinal stromal tumor29.9PDGFRA, SDHA, SDHC, S100A1, SDHB
9sarcoma29.8PDGFRA, CDK4, MDM2, GLI1, S100A1, HMGA2
10astrocytoma29.7MDM2, CDK4, IDH1, PDGFRA, SERPINA3
11adenoma29.5CDK4, HMGA2, CTNNB1, S100A1
12lipoma29.3MDM2, S100A1, HMGA2, LHFP, CDK4, LPP
13periostitis10.8
14extraskeletal chondroma10.7
15juxtacortical chondroma10.5
16paragangliomas 510.5SDHA
17laryngitis10.5
18gliosarcoma10.5CDK4
19lipomatosis10.5HMGA2
20pleomorphic adenoma10.5HMGA2
21pheochromocytoma10.5SDHD, SDHB
22familial colorectal cancer10.4SDHD, SDHB
23neurofibromatosis10.4SDHD, SDHB
24cervicitis10.4
25hereditary paraganglioma-pheochromocytoma syndromes10.4SDHC, SDHB, SDHD
26carotid body tumor10.4SDHC, SDHB, SDHD
27giant cell glioblastoma10.4MDM2
28phaeochromocytoma10.4SDHB, SDHC, SDHD
29interval angle-closure glaucoma10.4IDH1, IDH2
30multiple endocrine neoplasia type 2a10.4SDHB, SDHD, SDHC
31von hippel-lindau disease10.4SDHB, SDHD, SDHC
32multiple endocrine neoplasia10.4SDHC, SDHD, SDHB
33wermer syndrome10.4SDHC, SDHB, SDHD
34d-2-hydroxyglutaric aciduria10.4IDH1, IDH2
35hyperparathyroidism10.4SDHB, SDHD, SDHC
36intraductal papilloma10.4IDH2, IDH1
37hemangioma10.4SDHB, SDHD, SDHC
38neurofibroma10.3PDGFRA, S100A1
39hemangiopericytoma10.3MDM2, S100A1
40myxoid liposarcoma10.3MDM2, CDK4
41meningitis10.3
42osteochondroma10.3
43alveolar rhabdomyosarcoma10.3CDK4, MDM2
44ameloblastoma10.3SERPINA3, GLI1
45dedifferentiated liposarcoma10.2CDK4, HMGA2, MDM2
46central nervous system chondroma10.2
47smooth muscle tumor10.2S100A1, HMGA2
48asthma10.2
49chondroblastoma10.2
50gastric leiomyosarcoma10.2

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Symptoms for Chondroma

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Drugs & Therapeutics for Chondroma

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Drug clinical trials:

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Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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MalaCards organs/tissues related to Chondroma:

32
Tongue, Bone, Lung, Cortex, Spinal cord, Liver, Trachea, Heart, Thyroid, Breast, Prostate, Testis, Occipital lobe, Pituitary

Animal Models for Chondroma or affiliated genes

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MGI Mouse Phenotypes related to Chondroma:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
2MP:00053718.7RUNX2, PDGFRA, HMGA2, GLI1, MDM2, CTNNB1
3MP:00030128.6RUNX2, SDHB, PDGFRA, GLI1, MDM2, CTNNB1
4MP:00053678.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA
5MP:00053818.5RUNX2, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
6MP:00053808.5SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
7MP:00053828.5RUNX2, PDGFRA, HMGA2, MDM2, CTNNB1
8MP:00053798.5RUNX2, SDHD, PDGFRA, HMGA2, GLI1, CDK4
9MP:00107718.4RUNX2, PDGFRA, HMGA2, MDM2, CDK4, CTNNB1
10MP:00053698.2RUNX2, PDGFRA, S100A1, MDM2, CDK4, CTNNB1
11MP:00036318.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
12MP:00053858.0RUNX2, SDHD, PDGFRA, S100A1, MDM2, CDK4
13MP:00053788.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
14MP:00053868.0SDHD, PDGFRA, S100A1, HMGA2, GLI1, MDM2
15MP:00028737.9SDHD, PDGFRA, S100A1, GLI1, MDM2, CTNNB1
16MP:00053897.7CTNNB1, RUNX2, LPP, PDGFRA, HMGA2, GLI1
17MP:00053847.7RUNX2, SDHD, LPP, PDGFRA, GLI1, MDM2
18MP:00053767.5RUNX2, IDH1, SDHD, LPP, PDGFRA, HMGA2
19MP:00107687.4RUNX2, SDHD, SDHC, LPP, PDGFRA, GLI1

Publications for Chondroma

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Articles related to Chondroma:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Intracranial extra-axial chondroma: a case report. (24614393)
2014
2
A rare case of giant soft tissue chondroma of the wrist: A cytopathological study with review of the literature. (25190983)
2014
3
Chondroma located in cerebral parenchyma without meningeal attachment. (23172440)
2012
4
Extraskeletal chondroma in the auricle. (21119479)
2010
5
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
6
Massive chondroma of pelvis - case report. (19828919)
2009
7
Atypical location of a solitary intracranial chondroma without meningeal attachment. (17614089)
2007
8
Cutaneous chondroma with overlying pigmentation clinically mimicking dermatofibroma. (16403116)
2006
9
Intracortical chondroma: a report of two cases. (16284766)
2006
10
Nasal septum chondroma: a case report. (15875440)
2005
11
Laparoscopic presentation of a rib chondroma. (14676003)
2004
12
Soft-tissue chondroma in a finger: a case report. (12152379)
2002
13
Soft-tissue chondroma in the thumb. (12409791)
2002
14
Periosteal chondroma presenting as a subcutaneous mass in the thumb. (11733159)
2001
15
DNA flow cytometric analysis of chest-wall chondroma and chondrosarcoma. (8976036)
1996
16
Extraskeletal chondroma of the foot. (8867554)
1996
17
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. (7785598)
1995
18
Soft tissue chondroma of the fallopian tube. Differential diagnosis and histogenetic considerations. (7567687)
1995
19
Cardiac valvular chondroma. (7979695)
1994
20
Skull base chondroma of extracranial origin. (7822182)
1994
21
Soft-tissue chondroma as a cause of calcinosis in a patient with CREST syndrome. (8457459)
1993
22
Chondroma of the cervical spinal canal. Case report. (1306207)
1992
23
Benign cartilaginous tumor (chondroma) of the liver. (1634084)
1992
24
Intra-tendinous chondroma of a flexor tendon. (1779169)
1991
25
Chondroma of the lumbar spine, a rare cause of sciatica: case report. (2330093)
1990
26
Ossifying parasellar chondroma. Case report. (3117983)
1987
27
Chondroma of the nasal cavity and nasopharynx--a case of chondroma arising from the nasal septum. (3449038)
1987
28
Chondroma of falx: CT findings. (3782554)
1986
29
Case report 354: Chondroma of soft tissues with dystrophic calcification. (3961527)
1986
30
Extraskeletal ossifying chondroma in the knee. A case report. (3984711)
1985
31
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984
32
Malignant chondroma. (6582165)
1983
33
Orbital chondroma rodens in a dog. (500440)
1979
34
Intracerebral chondroma. (483149)
1979
35
The nasal chondroma. 2 case reports and a survey of the literature. (864317)
1977
36
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. 3. Cartilaginous tumors (chondroma, chondrosarcoma). (4853358)
1974
37
Intracranial solitary chondroma of dural origin. (5459528)
1970
38
Chondroma of the tongue. (5267622)
1970
39
Case reports and technical notes. Chondroma of the cervical spine. Case report. (5684408)
1968
40
AN EXCEPTIONALLY LARGE CHONDROMA OF THE MAXILLA: CASE REPORT. (14256819)
1965
41
Chondroma of sternum. A case report. (14441200)
1959
42
Chondroma of the larynx; report of a case with recurrence after twenty-eight years. (13636589)
1959
43
An endobronchial chondroma in a cachectic psychotic with hypopituitarism. (13253916)
1955
44
Chondroma of the vocal cord. (15412306)
1950
45
Chondroma of the larynx; report of a case. (15393512)
1949
46
Laryngeal chondroma. (18892972)
1948
47
Chondroma of the larynx; report of a case. (18921039)
1948
48
Chondroma of right knee]. (20280022)
1947
49
Chondroma of eighth costal cartilage]. (21001781)
1946
50
Osteofibro-chondroma of the scapula in a new born infant. (20275903)
1946

Variations for Chondroma

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Expression for genes affiliated with Chondroma

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Expression patterns in normal tissues for genes affiliated with Chondroma

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Pathways for genes affiliated with Chondroma

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Pathways related to Chondroma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SDHA, IDH1, IDH2
2
Show member pathways
Alzheimers Disease37
9.5SDHA, SDHC, SDHD, SDHB
39.5MDM2, HMGA2, RUNX2
49.4CDK4, MDM2, PDGFRA
59.3MDM2, CDK4, CTNNB1
69.3CTNNB1, CDK4, MDM2
79.3RUNX2, CDK4, CTNNB1
8
Show member pathways
9.3IDH2, SDHB, SDHD, SDHC, SDHA
99.2CTNNB1, MDM2, RUNX2
10
Show member pathways
9.2PDGFRA, MDM2, CTNNB1
11
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.0SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
12
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.0IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
13
Show member pathways
Signaling Pathways in Glioblastoma37
8.9PDGFRA, MDM2, CDK4, CTNNB1
148.9CTNNB1, CDK4, MDM2, PDGFRA
158.9CTNNB1, CDK4, MDM2, PDGFRA
168.6PDGFRA, GLI1, MDM2, CDK4, CTNNB1

Compounds for genes affiliated with Chondroma

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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid2410.3IDH1, IDH2
2fumarate44 1111.2SDHC, SDHD, SDHB
3thenoyltrifluoroacetone44 1111.2SDHB, SDHA
4Isocitric acid24 1111.2IDH2, IDH1
5isocitrate4410.1IDH2, IDH1, SDHB
6Fumaric acid2410.0SDHB, SDHD, SDHC, SDHA
7succinic acid28 24 1112.0SDHB, SDHD, SDHC, SDHA
8iron-sulfur4410.0SDHB, SDHD, SDHC, SDHA
9ubiquinone4410.0SDHB, SDHD, SDHC, SDHA
10Sulfide2410.0SDHB, SDHD, SDHC, SDHA
11QH2249.9SDHB, SDHD, SDHC, SDHA
12Ubiquinone Q2249.9SDHA, SDHC, SDHD, SDHB
13Ubiquinone Q1249.9SDHB, SDHD, SDHC, SDHA
14succinate449.9SDHB, SDHD, SDHC, SDHA
15FAD249.9SDHA, SDHC, SDHD, SDHB
16cyclopamine44 6110.7CTNNB1, GLI1
17nad+449.7SDHB, SDHA, MDM2
18glyceraldehyde 3-phosphate449.7IDH1, SDHB, SDHA, MDM2
19somatropin recombinant50 1110.6TSPAN31, CDK4
20trastuzumab44 50 1111.6CTNNB1, CDK4, MDM2
21gefitinib44 50 1111.5CTNNB1, CDK4, MDM2
22adpribose449.5CTNNB1, CDK4, MDM2
23geldanamycin44 50 61 1112.4CTNNB1, CDK4, MDM2
24roscovitine449.3CTNNB1, CDK4, MDM2, RUNX2
25leptomycin b44 6110.3LPP, MDM2, CTNNB1
26valproic acid44 50 24 1112.3CTNNB1, CDK4, RUNX2
27tgf beta1449.2RUNX2, PDGFRA, CDK4, CTNNB1
28rapamycin449.1PDGFRA, MDM2, CDK4, CTNNB1
29ly294002449.1RUNX2, MDM2, CDK4, CTNNB1
30pd 98,059449.1RUNX2, GLI1, MDM2, CDK4, CTNNB1
31doxorubicin44 50 1110.9CTNNB1, CDK4, MDM2, HMGA2
32glycogen44 249.9SDHB, S100A1, MDM2, CDK4, CTNNB1
33dexamethasone44 50 28 1111.9RUNX2, SERPINA3, MDM2, CDK4, CTNNB1
34steroid448.9RUNX2, SDHC, SERPINA3, MDM2, CDK4, CTNNB1
35thymidine44 249.9RUNX2, PDGFRA, MDM2, CDK4, CTNNB1
36progesterone44 28 61 24 1112.8CTNNB1, CDK4, MDM2, S100A1, SERPINA3
37alanine448.8RUNX2, SDHB, SERPINA3, MDM2, CDK4, CTNNB1
38oxygen44 249.7RUNX2, SDHB, SDHD, SDHC, SDHA, SERPINA3
39oligonucleotide448.7RUNX2, SERPINA3, PDGFRA, MDM2, CDK4, CTNNB1
40cysteine448.7SDHB, SERPINA3, S100A1, MDM2, CDK4, CTNNB1
41zinc44 249.6RUNX2, SDHB, SERPINA3, S100A1, GLI1, MDM2
42phosphatidylinositol448.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA, RUNX2
43iron44 249.6CDK4, SDHB, SDHD, SDHC, SDHA, SERPINA3
44arginine448.6SDHB, SERPINA3, MDM2, CDK4, CTNNB1
45vegf448.5RUNX2, SDHB, SDHC, PDGFRA, MDM2, CDK4
46paraffin448.4SERPINA3, PDGFRA, S100A1, HMGA2, MDM2, CDK4
47estrogen448.2RUNX2, SERPINA3, PDGFRA, S100A1, MDM2, CDK4
48calcium44 50 24 1111.1RUNX2, IDH1, SDHB, SERPINA3, PDGFRA, S100A1
49retinoic acid44 249.1RUNX2, SDHC, SERPINA3, PDGFRA, S100A1, HMGA2
50tyrosine448.0RUNX2, SDHB, PDGFRA, S100A1, MDM2, CDK4

GO Terms for genes affiliated with Chondroma

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Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7CTNNB1, HMGA2
2mitochondrial respiratory chain complex IIGO:0057499.6SDHA, SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:0057439.3IDH2, SDHB, SDHD, SDHC, SDHA
4mitochondrionGO:0057398.9IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
5nucleusGO:0056346.4RUNX2, SERPINA3, LPP, PDGFRA, S100A1, HMGA2

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.2IDH1, IDH2
2succinate metabolic processGO:00610510.2SDHA, SDHB
3isocitrate metabolic processGO:00610210.2IDH2, IDH1
4aerobic respirationGO:00906010.2SDHB, SDHC
52-oxoglutarate metabolic processGO:00610310.2IDH1, IDH2
6stem cell differentiationGO:04886310.1RUNX2, HMGA2
7negative regulation of cell cycle arrestGO:07115710.1CDK4, MDM2
8adrenal gland developmentGO:0303259.9HMGA2, PDGFRA
9respiratory electron transport chainGO:0229049.8SDHB, SDHD, SDHC, SDHA
10proximal/distal pattern formationGO:0099549.8CTNNB1, GLI1
11male genitalia developmentGO:0305399.7CTNNB1, PDGFRA
12pituitary gland developmentGO:0219839.7HMGA2, GLI1
13embryonic cranial skeleton morphogenesisGO:0487019.6PDGFRA, RUNX2
14cellular metabolic processGO:0442379.6IDH2, SDHB, SDHD, SDHC, SDHA
15odontogenesis of dentin-containing toothGO:0424759.5CTNNB1, PDGFRA, RUNX2
16tricarboxylic acid cycleGO:0060999.3SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
17small molecule metabolic processGO:0442819.2IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
18negative regulation of transcription, DNA-templatedGO:0458929.2CTNNB1, MDM2, HMGA2, RUNX2
19positive regulation of transcription, DNA-templatedGO:0458939.1RUNX2, HMGA2, GLI1, CTNNB1
20negative regulation of transcription from RNA polymerase II promoterGO:0001228.8CTNNB1, MDM2, HMGA2, S100A1
21positive regulation of cell proliferationGO:0082848.3RUNX2, TSPAN31, PDGFRA, GLI1, MDM2, CDK4

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00817710.1SDHB, SDHA
2isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
3ubiquinone bindingGO:04803910.0SDHB, SDHD
4succinate dehydrogenase activityGO:0001049.9SDHA, SDHC, SDHD
5repressing transcription factor bindingGO:0704919.6CTNNB1, RUNX2
6electron carrier activityGO:0090559.5SDHC, SDHD, SDHB
7protein bindingGO:0055156.1RUNX2, SDHB, SDHA, SERPINA3, LPP, PDGFRA

Products for genes affiliated with Chondroma

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Sources for Chondroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet