MCID: CHN010
MIFTS: 41

Chondroma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Chondroma

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Aliases & Descriptions for Chondroma:

Name: Chondroma 11 48 50 39 13 68
Central Chondroma 11
 
Chondroma Nos 11
Enchondroma 68

Classifications:



External Ids:

Disease Ontology11 DOID:2602
MeSH39 D002812
NCIt45 C53459

Summaries for Chondroma

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Wikipedia:71 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards based summary: Chondroma, also known as central chondroma, is related to paraganglioma and gastric stromal sarcoma and gastrointestinal stromal tumor, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Citrate cycle (TCA cycle). Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and mortality/aging.

Disease Ontology:11 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Related Diseases for Chondroma

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Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma and gastric stromal sarcoma28.9SDHB, SDHC, SDHD
2gastrointestinal stromal tumor28.3ACTC1, SDHB, SDHC, SDHD
3extraskeletal chondroma12.2
4juxtacortical chondroma12.0
5central nervous system chondroma11.8
6dysplasia epiphysealis hemimelica with chondromas and osteochondromas11.7
7phalanx chondroma11.7
8carney triad11.1
9carpotarsal osteochondromatosis10.9
10paragangliomas 1, with or without deafness10.8
11chondroid chordoma10.8
12periostitis10.5
13colonic pseudo-obstruction10.4CTNNB1, GLI1
14melanotic medulloblastoma10.3CTNNB1, GLI1
15foramen magnum meningioma10.3CTNNB1, GLI1
16polyomavirus allograft nephropathy10.3ACTC1, CTNNB1
17adenomyoma10.2CTNNB1, PTH1R
18retinoschisis autosomal dominant10.2SDHB, SDHD
19skin glomangioma10.2ACTC1, SDHB
20ameloblastoma10.2SDHB, SDHD
21laryngitis10.2
22pancreatic somatostatinoma10.1CTNNB1, GLI1
23chondrosarcoma10.1
24mild phosphoribosylpyrophosphate synthetase superactivity10.1ACTC1, PTH1R
25small cell neuroendocrine carcinoma10.1CTNNB1, PTH1R
26dysgammaglobulinemia10.1PTH1R, SDHB
27cervicitis10.1
28pancreatitis, pediatric10.1SDHC, SDHD
29pediatric infratentorial ependymoma10.0SDHB, SDHD
30leiomyosarcoma10.0
31pleuropulmonary blastoma type 29.9ACTC1, HMGA2
32meningitis9.9
33osteochondroma9.9
34gastrointestinal neuroendocrine tumor9.9CTNNB1, HMGA2
35steroid lipomatosis9.9HMGA2, SDHB
36in situ carcinoma9.9SDHB, SDHD
37malignant spindle cell melanoma9.8HMGA2, SDHB
38asthma9.8
39chondroblastoma9.8
40gastric leiomyosarcoma9.8
41enchondroma9.8
42cervix endometrial stromal tumor9.8CTNNB1, HMGA2
43torticollis, familial9.7SDHB, SDHC, SDHD
44neuroendocrine carcinoma of the cervix9.7SDHB, SDHC, SDHD
45carcinoid tumors, intestinal9.7SDHB, SDHC, SDHD
46chordoma9.7
47sarcoma9.7
48hyperostosis9.7
49cerebritis9.7
50radiculopathy9.7

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Symptoms & Phenotypes for Chondroma

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UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-3510.2CTNNB1, SDHC

MGI Mouse Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.9ACTC1, CTNNB1, GLI1, PTH1R, SDHB, SDHC

Drugs & Therapeutics for Chondroma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone SarcomasRecruitingNCT02389244Phase 2
2Low Grade Chondrosarcoma Versus EnchondromaCompletedNCT02996747

Search NIH Clinical Center for Chondroma


Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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MalaCards organs/tissues related to Chondroma:

36
Tongue, Bone, Lung, Spinal cord, Trachea, Breast, Liver

Publications for Chondroma

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Articles related to Chondroma:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Trigger Finger Caused by Extraskeletal Chondroma. (27817941)
2017
2
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. (27185409)
2016
3
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. (27602219)
2016
4
Intradural chondroma in the cervical spine: case report. (27740393)
2016
5
Case report of chondroma in a grass carp (Ctenopharyngodon idella). (27482364)
2016
6
Intracranial dural based chondroma. (26602798)
2016
7
Breast Chondroma. (27797122)
2016
8
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. (27461824)
2016
9
A case of chondroma cutis showing callus-like appearance. (26932734)
2016
10
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. (27213734)
2016
11
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. (27179652)
2016
12
Scrotal chondroma in a young male: A rare case report. (27166053)
2016
13
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? (27026930)
2016
14
Arytenoid cartilage chondroma. (25960446)
2015
15
Endobronchial chondroma: An unusual case of bronchial obstruction. (25770939)
2015
16
Extraskeletal Chondroma of the Gluteal Region Along with Sporadic Neurofibroma - An Unusual Presentation. (26155485)
2015
17
Extensive Periosteal Chondroma in the Middle Phalanx with Pathological Fracture Reconstructed with Strut Bone Grafting. (26051780)
2015
18
Primary spinal extraosseous cervical chondroma in an adult. (25751486)
2015
19
Soft tissue chondroma presenting as a dermal mass in the toe. (26015904)
2015
20
Chondroma of the falx cerebri. (25909200)
2015
21
Orbital Chondroma: A rare mesenchymal tumor of orbit. (26265654)
2015
22
Chondroma of the scalp. (26405500)
2015
23
True cutaneous chondroma: a case report. (25998426)
2015
24
A rare case of bladder chondroma. (25844100)
2015
25
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. (26091072)
2015
26
Periosteal chondroma of the femur: A case report and review of the literature. (25789014)
2015
27
Bilateral extraskeletal chondroma of the neck. (26381679)
2015
28
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. (26156668)
2015
29
Nasal chondroma presenting as hypertelorism. (25730333)
2015
30
Extraosseous chondroma of anterior neck in pediatric patient. (26104481)
2015
31
Chondroma of Cerebral Falx: A Rare Intracranial Diagnosis. (26454394)
2015
32
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. (26918096)
2015
33
Novel Pathologic Finding of Digital Soft Tissue Chondroma in a Child: A Case Report and Review of Literature. (26113665)
2015
34
Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review. (26834817)
2015
35
Extraskeletal Chondroma in the Popliteal Region: A Case Report. (26960310)
2015
36
Periosteal chondroma of the distal tibia: Computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. (26137286)
2015
37
A rare case of giant soft tissue chondroma of the wrist: A cytopathological study with review of the literature. (25190983)
2014
38
Imaging features of juxtacortical chondroma in children. (23955368)
2014
39
A rare case of chondroma of the parotid gland. (24868998)
2014
40
Focal periosteal chondroma of the hand: a review of 24 cases. (25172018)
2014
41
Soft tissue chondroma of the oral cavity: an extremely rare tumour localized on the hard palate. (24715909)
2014
42
Arytenoid cartilage chondroma. (25181657)
2014
43
Convexity dural chondroma: a case report with pathological and molecular analysis. (25250651)
2014
44
Extradural chondroma presenting as lumbar mass with compressive neuropathy. (25336836)
2014
45
True chondroma of the mandibular condyle: A rare case. (25593880)
2014
46
Intracranial extra-axial chondroma: a case report. (24614393)
2014
47
Chondroblastoma-like chondroma of the hand: case report. (24656394)
2014
48
Chondroma of the diaphragm mimicking a giant liver tumor with calcification: report of a case. (24931544)
2014
49
A Case of Giant Skull Base Chondroma. (25408932)
2014
50
Falx chondroma with hyperostosis of the scull: a case report. (25233692)
2014

Variations for Chondroma

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Expression for genes affiliated with Chondroma

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Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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GO Terms for genes affiliated with Chondroma

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Cellular components related to Chondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)GO:00057499.7SDHB, SDHC, SDHD
2respiratory chain complex IIGO:00452739.7SDHB, SDHC
3protein-DNA complexGO:00329939.3CTNNB1, HMGA2

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1aerobic respirationGO:000906010.4SDHB, SDHC
2chondrocyte differentiationGO:000206210.2HMGA2, PTH1R
3pituitary gland developmentGO:002198310.2GLI1, HMGA2
4epithelial to mesenchymal transitionGO:000183710.1CTNNB1, HMGA2
5epithelial tube branching involved in lung morphogenesisGO:006044110.1CTNNB1, HMGA2
6bone resorptionGO:004545310.0CTNNB1, PTH1R
7cell maturationGO:004846910.0CTNNB1, PTH1R
8dorsal/ventral pattern formationGO:000995310.0CTNNB1, GLI1
9proximal/distal pattern formationGO:00099549.8CTNNB1, GLI1
10regulation of osteoblast differentiationGO:00456679.7CTNNB1, GLI1
11tricarboxylic acid cycleGO:00060999.3SDHB, SDHC, SDHD
12positive regulation of gene expressionGO:00106289.1ACTC1, CTNNB1, HMGA2
13positive regulation of cell proliferationGO:00082849.0CTNNB1, GLI1, HMGA2, PTH1R

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase activityGO:00001049.9SDHC, SDHD
2electron carrier activityGO:00090559.8SDHB, SDHC, SDHD
3ubiquinone bindingGO:00480399.8SDHB, SDHD
4SMAD bindingGO:00463329.6CTNNB1, HMGA2

Sources for Chondroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet