MCID: CHN010
MIFTS: 55

Chondroma malady

Summaries for Chondroma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards: Chondroma, also known as central chondroma, is related to chondrosarcoma and paraganglioma. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Pyruvate metabolism. The compounds cycloheximide and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

chondroma 8 42 10 44 60
central chondroma 8
chondroma nos 8


External Ids:

Disease Ontology8 DOID:2602
NCIt39 C53459
MeSH34 D002812

Related Diseases for Chondroma

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17GeneCards, 18GeneDecks
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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.6SERPINA3, PTHLH, HMGA2, CDK4, MDM2, PDGFRA
2paraganglioma30.6IDH2, S100A1, KIT, SDHD, SDHB, SDHC
3leiomyosarcoma30.4KIT, CDK4, MDM2, PDGFRA, S100A1
4chondroblastoma30.0PTHLH
5meningioma30.0S100A1
6chordoma30.0PDGFRA, S100A1
7sarcoma30.0S100A1, PDGFRA, MDM2, HMGA2, KIT, CDK4
8pituitary adenoma29.8HMGA2, CDK4
9glomus tumor29.8SDHB, SDHD, S100A1
10fibrosarcoma29.8PDGFRA, MDM2
11gastrointestinal stromal tumor29.8PDGFRA, KIT
12adenoma29.8HMGA2, CDK4, CTNNB1, S100A1
13carney triad29.8SDHC, SDHB, SDHD, KIT, PDGFRA
14leiomyoma29.8S100A1, PDGFRA, KIT, HMGA2
15astrocytoma29.8IDH1, PDGFRA, MDM2, CDK4, SERPINA3
16lipoma29.7HMGA2, CDK4, LPP, MDM2, S100A1, LHFP
17squamous cell carcinoma29.7S100A1, PDGFRA, CTNNB1, MDM2, GLI1, CDK4
18periostitis10.8
19extraskeletal chondroma10.6
20juxtacortical chondroma10.5
21laryngitis10.5
22cervicitis10.3
23gastric leiomyosarcoma10.2
24meningitis10.2
25periosteal chondrosarcoma10.2
26central nervous system chondroma10.1
27asthma10.1
28radiculopathy10.0
29carpal tunnel syndrome10.0
30epithelioid leiomyosarcoma10.0
31mesenchymal chondrosarcoma10.0
32carpotarsal osteochondromatosis10.0
33ollier disease10.0PTHLH
34gliosarcoma10.0CDK4
35arthritis10.0SERPINA3
36dermatofibrosarcoma10.0MDM2
37basal cell carcinoma10.0GLI1
38renal oncocytoma10.0S100A1
39seminal vesicle tumor10.0SDHA
40cervical cancer10.0MDM2
41acute leukemia10.0KIT
42pheochromocytoma10.0SDHD, SDHB
43craniopharyngioma10.0CTNNB1
44uterine carcinosarcoma10.0KIT
45hereditary paraganglioma-pheochromocytoma syndromes10.0SDHD, SDHB, SDHC
46von hippel-lindau disease10.0SDHC, SDHB, SDHD
47hemangioma10.0SDHC, SDHB, SDHD
48paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
49carotid body tumor10.0SDHD, SDHB, SDHC
50thymus cancer10.0KIT

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Clinical Features for Chondroma

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Drugs & Therapeutics for Chondroma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chondroma

Drug clinical trials:

Search ClinicalTrials for Chondroma

Search NIH Clinical Center for Chondroma

Search CenterWatch for Chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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32MalaCards
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MalaCards organs/tissues related to Chondroma:

32
Tongue, Bone, Lung, Cortex, Spinal cord, Trachea, Occipital lobe, Testis, Prostate, Breast, Thyroid, Liver, Heart, Pituitary

Animal Models for Chondroma or affiliated genes

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36MGI
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Publications for Chondroma

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50PubMed
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Articles related to Chondroma:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Periosteal chondroma of the proximaltibia mimicking Osgood-Schlatter's disease. (23610879)
2013
2
Chondroma of falx: case report of a rare condition. (22418994)
2012
3
Chondroma (cartilaginous choristoma) of the tongue: report of a case. (21723021)
2012
4
Giant chondroma of the head and neck causing gross facial deformity. (22359137)
2012
5
Soft tissue chondroma of Hoffa's fat pad. (22489403)
2012
6
Solitary intracerebral chondroma without meningeal attachment: a case report with review of the literature. (21672374)
2011
7
Laryngeal chondroma: a rare diagnosis in this localization. (22937396)
2011
8
Cartilage choristoma (soft tissue chondroma): a rare presentation in the lower lip. (19476101)
2009
9
Intracranial falx chondroma: literature review and a case report. (17913345)
2008
10
Imaging diagnosis--cervical spine chondroma in a dog. (18833956)
2008
11
Pleural chondroma. (18245719)
2008
12
Atypical location of a solitary intracranial chondroma without meningeal attachment. (17614089)
2007
13
Intracortical chondroma: a report of two cases. (16284766)
2006
14
Chondroma of the subcutaneous bursa of the Achilles tendon. (16536214)
2005
15
Periosteal chondroma of the rib--report of a case and literature review. (16150361)
2005
16
Periosteal chondroma of the proximal radius: a case report. (16878776)
2005
17
Extraskeletal chondroma as a cause of carpal tunnel syndrome: a case report. (16568538)
2005
18
Laparoscopic presentation of a rib chondroma. (14676003)
2004
19
Chondroma of epithelial cell origin. (12819041)
2003
20
Giant chondroma arising from the dura mater of the convexity. Case report and review of the literature. (11213975)
2001
21
Childhood periosteal chondroma. (11110148)
2000
22
Intracapsular chondroma of the elbow producing a posterior interosseous nerve palsy. (9571497)
1998
23
Chondroma of the external auditory canal. (9624379)
1998
24
Association of gastrointestinal stromal tumor (leiomyosarcoma), pulmonary chondroma, and nonfunctional retroperitoneal paraganglioma. (9835913)
1998
25
Dural chondroma with fat tissue. (9265964)
1997
26
Diffuse mineralization of extraskeletal chondroma: a case report. (9134585)
1997
27
Intracranial chondroma. Report of two cases and review of the literature. (8738927)
1996
28
MR imaging of periosteal chondroma. (1939750)
1991
29
Chondroma of the tongue. (2911063)
1989
30
Two cases of periosteal chondroma. (3213465)
1988
31
A large soft-tissue chondroma arising from the posterior mediastinum. (3396292)
1988
32
Extraskeletal ossifying chondroma in the knee. A case report. (3984711)
1985
33
Prostatic chondroma. (2579502)
1985
34
Thoracic cord compression from chondroma of rib. A case report. (6495020)
1984
35
Intracerebral chondroma. (483149)
1979
36
Radiologic diagnosis of chondroma and chondrosarcoma of the larynx. (1120013)
1975
37
Chondroma of the mandible with early malignant changes. (4523074)
1973
38
Sternal chondroma. (5775732)
1969
39
Second primary laryngeal chondroma. (5765801)
1969
40
Chondroma of the larynx with report of 4 cases. (5738889)
1968
41
Chondroma of a finger. (5612887)
1967
42
Juxtacortical chondroma of the hyoid bone. Report of a case. (6058416)
1967
43
Intracranial meningeal chondroma. (14490078)
1961
44
An unusual case of hamarto-chondroma. (13719765)
1960
45
Intracranial chondroma. (13707276)
1960
46
Chondroma of sternum. A case report. (14441200)
1959
47
Chondroma of nasopharynx. (13838446)
1959
48
The roentgenologic characteristics of chondroma of the larynx. (13595164)
1958
49
An unusual hamartoma (so-called chondroma of the lung). (20256746)
1947
50
Chondroma. (20988923)
1946

Genetic Variations for Chondroma

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Expression for genes affiliated with Chondroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Chondroma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5RUNX2
2fumarate44 1111.2SDHC, SDHB, SDHD
3UBIQUINONE-11110.0SDHB, SDHC, SDHD, SDHA
42-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHA, SDHC, SDHB, SDHD
5isocitrate4410.0IDH1, IDH2, SDHB
6succinic acid28 11 2412.0SDHA, SDHC, SDHB, SDHD
7iron-sulfur4410.0SDHB, SDHD, SDHC, SDHA
8ubiquinone4410.0SDHB, SDHA, SDHC, SDHD
9naphthol as-d chloroacetate4410.0KIT, SERPINA3
10succinate4410.0SDHD, SDHB, SDHA, SDHC
11thenoyltrifluoroacetone44 1111.0SDHA, SDHB
12ag-1296449.8PTHLH, PDGFRA, KIT
13somatropin recombinant49 1110.7CDK4, TSPAN31
14paclitaxel44 49 1111.6CDK4, MDM2, CTNNB1
15lead449.5PTHLH, MDM2, CDK4, KIT
16dexamethasone44 49 28 1112.5MDM2, CDK4, CTNNB1
17glucose449.5GLI1, SERPINA3, SDHB, RUNX2, PTHLH
18glyceraldehyde 3-phosphate449.5SDHA, IDH1, SDHB, MDM2
19valine449.4MDM2, KIT, PTHLH, SERPINA3, CDK4
20roscovitine449.4CDK4, CTNNB1, RUNX2, MDM2
21leptomycin b44 5910.3CTNNB1, LPP, PTHLH, MDM2
22trastuzumab44 49 1111.3CTNNB1, MDM2, CDK4, KIT
23steroid449.3CDK4, PTHLH, SERPINA3, SDHC, RUNX2, MDM2
24gefitinib44 49 1111.3MDM2, KIT, CDK4, CTNNB1
25geldanamycin44 49 59 1112.3KIT, MDM2, CTNNB1, CDK4
26tgf beta1449.1CDK4, PTHLH, CTNNB1, PDGFRA, RUNX2
27imatinib44 49 1111.1KIT, CTNNB1, PDGFRA, MDM2
28doxorubicin44 49 1111.0KIT, HMGA2, MDM2, CDK4, CTNNB1
29arginine448.9CTNNB1, SERPINA3, SDHB, MDM2, PTHLH, CDK4
30rapamycin448.9PDGFRA, CDK4, KIT, MDM2, CTNNB1
31testosterone44 59 11 2411.8MDM2, CDK4, KIT, CTNNB1, SDHB, PTHLH
32pd 98,059448.7MDM2, GLI1, CDK4, CTNNB1, KIT, RUNX2
33alanine448.7RUNX2, PTHLH, SDHB, SERPINA3, CDK4, MDM2
34oxygen44 249.6SDHD, RUNX2, CDK4, PTHLH, SDHC, SDHA
35cisplatin44 49 59 1111.6CTNNB1, MDM2, CDK4, HMGA2, PTHLH
36thymidine44 249.4KIT, CDK4, MDM2, CTNNB1, PDGFRA, RUNX2
37iron44 249.4CDK4, SDHA, SDHC, SDHB, SDHD, S100A1
38threonine448.4PTHLH, MDM2, CDK4, KIT, CTNNB1, SERPINA3
39zinc44 249.4SDHB, RUNX2, S100A1, MDM2, GLI1, CDK4
40oligonucleotide448.4SERPINA3, MDM2, CTNNB1, KIT, PDGFRA, RUNX2
41phosphatidylinositol448.1KIT, GLI1, MDM2, CTNNB1, PDGFRA, RUNX2
42glycogen44 249.1MDM2, CTNNB1, S100A1, PTHLH, CDK4, KIT
43progesterone44 59 28 11 2412.1MDM2, CTNNB1, KIT, CDK4, SERPINA3, S100A1
44nitric oxide44 11 2410.0PTHLH, KIT, MDM2, CDK4, S100A1, RUNX2
45vegf448.0PDGFRA, RUNX2, CDK4, KIT, PTHLH, SDHB
46cysteine447.9CTNNB1, S100A1, MDM2, CDK4, SERPINA3, SDHB
47paraffin447.5CTNNB1, PDGFRA, S100A1, KIT, MDM2, CDK4
48calcium44 49 11 2410.3MDM2, KIT, PDGFRA, S100A1, RUNX2, CDK4
49retinoic acid44 248.3S100A1, PDGFRA, SDHC, SERPINA3, PTHLH, HMGA2
50tyrosine447.3CTNNB1, RUNX2, SDHB, PTHLH, KIT, CDK4

GO Terms for genes affiliated with Chondroma

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16Gene Ontology
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Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7HMGA2, CTNNB1
2mitochondrial respiratory chain complex IIGO:0057499.6SDHA, SDHC, SDHB, SDHD
3mitochondrial inner membraneGO:0057439.2IDH2, SDHD, SDHB, SDHC, SDHA
4nucleusGO:0056345.7RUNX2, S100A1, PDGFRA, CTNNB1, MDM2, LPP

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.1IDH1, IDH2
2isocitrate metabolic processGO:00610210.0IDH2, IDH1
3respiratory electron transport chainGO:0229049.7SDHA, SDHC, SDHB, SDHD
4negative regulation of chondrocyte differentiationGO:0323319.7PTHLH, CTNNB1
5stem cell differentiationGO:0488639.7RUNX2, KIT, HMGA2
6succinate metabolic processGO:0061059.7SDHA, SDHB
7positive regulation of phospholipase C activityGO:0108639.6KIT, PDGFRA
8cellular metabolic processGO:0442379.5IDH2, SDHD, SDHB, SDHC, SDHA
9tricarboxylic acid cycleGO:0060999.3SDHA, IDH1, IDH2, SDHD, SDHB, SDHC
10odontogenesis of dentin-containing toothGO:0424759.2RUNX2, PDGFRA, CTNNB1
11positive regulation of cell proliferationGO:0082847.9RUNX2, PDGFRA, MDM2, GLI1, CDK4, KIT

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
2succinate dehydrogenase (ubiquinone) activityGO:0081779.9SDHA, SDHB
3ubiquinone bindingGO:0480399.8SDHB, SDHD
4protein bindingGO:0055155.8LPP, MDM2, CTNNB1, PDGFRA, S100A1, GLI1

Products for genes affiliated with Chondroma

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Sources for Chondroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet