Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 72 49 51 41 14 69
Central Chondroma 12
Enchondroma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 41 D002812
NCIt 46 C53459

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to juxtacortical chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include tongue, bone and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 juxtacortical chondroma 32.6 CTNNB1 HMGA2 PTH1R
2 carney triad 32.4 SDHB SDHC SDHD
3 paragangliomas 1 31.0 SDHB SDHC SDHD
4 paraganglioma 29.8 SDHB SDHC SDHD
5 chondromyxoid fibroma 29.6 ACTC1 PTH1R
6 glomus tumor 29.2 ACTC1 SDHB SDHD
7 paraganglioma and gastric stromal sarcoma 29.0 SDHB SDHC SDHD
8 gastrointestinal stromal tumor 28.6 ACTC1 SDHB SDHC SDHD
9 extraskeletal chondroma 12.3
10 central nervous system chondroma 11.9
11 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 11.9
12 phalanx chondroma 11.9
13 carpotarsal osteochondromatosis 11.0
14 chondroid chordoma 10.9
15 periostitis 10.6
16 nodular medulloblastoma 10.3 CTNNB1 GLI1
17 laryngitis 10.2
18 pseudosarcomatous fibromatosis 10.2 ACTC1 CTNNB1
19 chondrosarcoma 10.2
20 polymorphous low-grade adenocarcinoma 10.2 ACTC1 CTNNB1
21 cervicitis 10.2
22 fibromatosis 10.2 ACTC1 CTNNB1
23 infratentorial cancer 10.1 CTNNB1 GLI1
24 nonsyndromic paraganglioma 10.1
25 leiomyosarcoma 10.1
26 heart cancer 10.0 PTH1R SDHB
27 meningitis 10.0
28 osteochondroma 10.0
29 pancreas adenocarcinoma 10.0 CTNNB1 GLI1
30 episodic pain syndrome, familial, 1 9.9
31 dedifferentiated liposarcoma 9.9 ACTC1 HMGA2
32 multiple endocrine neoplasia, type iia 9.9 SDHB SDHD
33 smooth muscle tumor 9.9 ACTC1 HMGA2
34 atypical teratoid rhabdoid tumor 9.9 CTNNB1 HMGA2
35 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
36 asthma 9.9
37 chondroblastoma 9.9
38 gastric leiomyosarcoma 9.9
39 enchondroma 9.9
40 gastrointestinal system benign neoplasm 9.8 CTNNB1 HMGA2
41 multiple endocrine neoplasia 9.8 SDHB SDHC
42 carpal tunnel syndrome 9.8
43 chordoma 9.8
44 osteoid osteoma 9.8
45 meningioma, familial 9.8
46 mononeuropathy of the median nerve, mild 9.8
47 sarcoma 9.8
48 hyperostosis 9.8
49 cerebritis 9.8
50 radiculopathy 9.8

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.5 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.5 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.5 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.5 SDHC CTNNB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.5 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.5 CTNNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 SDHC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.5 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.5 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.5 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 SDHC

MGI Mouse Phenotypes related to Chondroma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 SDHC SDHD ACTC1 CTNNB1 GLI1 PTH1R
2 neoplasm MP:0002006 9.35 SDHD CTNNB1 GLI1 PTH1R SDHB
3 normal MP:0002873 9.02 SDHB SDHD ACTC1 CTNNB1 GLI1

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

38
Tongue, Bone, Lung, Spinal Cord, Trachea, Breast, Liver

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 563)
# Title Authors Year
1
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
2
Soft-Tissue Chondroma in the Preauricular Region: An Unusual Presentation. ( 29387304 )
2018
3
Soft tissue chondroma on the lip: Clinical, histopathological and ultrasonographic findings. ( 29115679 )
2017
4
Giant convexity chondroma with dural involvement: Case report and review of literature. ( 28484562 )
2017
5
Synovial chondroma in Hoffa's fat pad: Case report and literature review of a rare disorder. ( 28130075 )
2017
6
Extraskeletal Chondroma with Concomitant Arthrosis of the Foot at the First Metatarsophalangeal Joint<sub>A Case Report</sub>. ( 29252024 )
2017
7
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
8
Chondroma of the Bladder: A Case Report and Review of the Literature. ( 28479478 )
2017
9
Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. ( 29106539 )
2017
10
Trigger Finger Caused by Extraskeletal Chondroma. ( 27817941 )
2017
11
Chondroma of the Bladder: An Atypical Localization. ( 29138708 )
2017
12
Extraskeletal Chondroma of the Index Finger: A Case Report. ( 28690520 )
2017
13
Intracranial dural chondroma in a child-conventional and advanced neuroimaging characteristics and differential diagnosis. ( 28631961 )
2017
14
Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report. ( 28592723 )
2017
15
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. ( 27461824 )
2016
16
Scrotal chondroma in a young male: A rare case report. ( 27166053 )
2016
17
A case of chondroma cutis showing callus-like appearance. ( 26932734 )
2016
18
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? ( 27026930 )
2016
19
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. ( 27185409 )
2016
20
Intracranial dural based chondroma. ( 26602798 )
2016
21
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. ( 27602219 )
2016
22
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. ( 27213734 )
2016
23
Breast Chondroma. ( 27797122 )
2016
24
Case report of chondroma in a grass carp (Ctenopharyngodon idella). ( 27482364 )
2016
25
Intradural chondroma in the cervical spine: case report. ( 27740393 )
2016
26
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. ( 27179652 )
2016
27
Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review. ( 26834817 )
2015
28
Extraskeletal Chondroma of the Gluteal Region Along with Sporadic Neurofibroma - An Unusual Presentation. ( 26155485 )
2015
29
A rare case of bladder chondroma. ( 25844100 )
2015
30
Arytenoid cartilage chondroma. ( 25960446 )
2015
31
Periosteal chondroma of the distal tibia: Computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. ( 26137286 )
2015
32
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. ( 26091072 )
2015
33
Soft tissue chondroma presenting as a dermal mass in the toe. ( 26015904 )
2015
34
Endobronchial chondroma: An unusual case of bronchial obstruction. ( 25770939 )
2015
35
Orbital Chondroma: A rare mesenchymal tumor of orbit. ( 26265654 )
2015
36
Extraosseous chondroma of anterior neck in pediatric patient. ( 26104481 )
2015
37
Chondroma of the scalp. ( 26405500 )
2015
38
True cutaneous chondroma: a case report. ( 25998426 )
2015
39
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. ( 26156668 )
2015
40
Chondroma of Cerebral Falx: A Rare Intracranial Diagnosis. ( 26454394 )
2015
41
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. ( 26918096 )
2015
42
Primary spinal extraosseous cervical chondroma in an adult. ( 25751486 )
2015
43
Extraskeletal Chondroma in the Popliteal Region: A Case Report. ( 26960310 )
2015
44
Periosteal chondroma of the femur: A case report and review of the literature. ( 25789014 )
2015
45
Novel Pathologic Finding of Digital Soft Tissue Chondroma in a Child: A Case Report and Review of Literature. ( 26113665 )
2015
46
Chondroma of the falx cerebri. ( 25909200 )
2015
47
Nasal chondroma presenting as hypertelorism. ( 25730333 )
2015
48
Bilateral extraskeletal chondroma of the neck. ( 26381679 )
2015
49
Extensive Periosteal Chondroma in the Middle Phalanx with Pathological Fracture Reconstructed with Strut Bone Grafting. ( 26051780 )
2015
50
True chondroma of the mandibular condyle: A rare case. ( 25593880 )
2014

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 9.16 CTNNB1 HMGA2
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 ACTC1 CTNNB1 HMGA2
2 chondrocyte differentiation GO:0002062 9.48 HMGA2 PTH1R
3 dorsal/ventral pattern formation GO:0009953 9.46 CTNNB1 GLI1
4 epithelial to mesenchymal transition GO:0001837 9.43 CTNNB1 HMGA2
5 cell maturation GO:0048469 9.4 CTNNB1 PTH1R
6 aerobic respiration GO:0009060 9.37 SDHB SDHC
7 proximal/distal pattern formation GO:0009954 9.32 CTNNB1 GLI1
8 bone resorption GO:0045453 9.26 CTNNB1 PTH1R
9 regulation of osteoblast differentiation GO:0045667 9.16 CTNNB1 GLI1
10 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHC SDHD
11 tricarboxylic acid cycle GO:0006099 8.8 SDHB SDHC SDHD

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.5 CTNNB1 GLI1 HMGA2
2 SMAD binding GO:0046332 9.37 CTNNB1 HMGA2
3 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
4 ubiquinone binding GO:0048039 9.26 SDHB SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.96 SDHB SDHD
6 succinate dehydrogenase activity GO:0000104 8.62 SDHC SDHD

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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