MCID: CHN010
MIFTS: 58

Chondroma malady

Rare diseases, Cancer diseases categories

Summaries for Chondroma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards: Chondroma, also known as central chondroma, is related to paraganglioma and chondrosarcoma. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Glucose / Energy Metabolism and Alzheimer's disease. The compounds Oxalosuccinic acid and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:9 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

chondroma 9 44 11 46 63
central chondroma 9
chondroma nos 9


External Ids:

Disease Ontology9 DOID:2602
MeSH36 D002812
NCIt41 C53459

Related Diseases for Chondroma

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18GeneCards, 19GeneDecks
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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma30.7SDHB, SDHD, SDHC, SDHA, S100A1, IDH2
2chondrosarcoma30.6SERPINA3, MDM2, PDGFRA, HMGA2, CDK4, RUNX2
3leiomyosarcoma30.5S100A1, MDM2, PDGFRA, CDK4
4carney triad30.4SDHC, SDHD, PDGFRA, SDHB
5chordoma30.1PDGFRA, S100A1
6sarcoma30.0PDGFRA, CDK4, MDM2, GLI1, S100A1, HMGA2
7paraganglioma and gastric stromal sarcoma30.0SDHD, SDHC, SDHB
8glomus tumor30.0SDHB, SDHD, S100A1
9leiomyoma29.9PDGFRA, HMGA2, S100A1
10gastrointestinal stromal tumor29.9PDGFRA, SDHA, SDHC, S100A1, SDHB
11astrocytoma29.8MDM2, CDK4, IDH1, PDGFRA, SERPINA3
12adenoma29.8CDK4, HMGA2, CTNNB1, S100A1
13lipoma29.7MDM2, S100A1, HMGA2, LHFP, CDK4, LPP
14periostitis10.8
15extraskeletal chondroma10.7
16juxtacortical chondroma10.5
17laryngitis10.5
18cervicitis10.4
19meningitis10.3
20osteochondroma10.3
21gastric leiomyosarcoma10.1
22central nervous system chondroma10.1
23asthma10.1
24enchondroma10.1
25choristoma10.1
26paragangliomas 510.1SDHA
27gliosarcoma10.1CDK4
28lipomatosis10.1HMGA2
29pleomorphic adenoma10.1HMGA2
30pheochromocytoma10.1SDHD, SDHB
31familial colorectal cancer10.1SDHD, SDHB
32neurofibromatosis10.1SDHD, SDHB
33hereditary paraganglioma-pheochromocytoma syndromes10.1SDHC, SDHB, SDHD
34carotid body tumor10.1SDHC, SDHB, SDHD
35giant cell glioblastoma10.1MDM2
36phaeochromocytoma10.1SDHB, SDHC, SDHD
37interval angle-closure glaucoma10.1IDH1, IDH2
38multiple endocrine neoplasia type 2a10.1SDHB, SDHD, SDHC
39von hippel-lindau disease10.1SDHB, SDHD, SDHC
40multiple endocrine neoplasia10.1SDHC, SDHD, SDHB
41wermer syndrome10.1SDHC, SDHB, SDHD
42d-2-hydroxyglutaric aciduria10.1IDH1, IDH2
43hyperparathyroidism10.1SDHB, SDHD, SDHC
44intraductal papilloma10.1IDH2, IDH1
45hemangioma10.1SDHB, SDHD, SDHC
46neurofibroma10.1PDGFRA, S100A1
47hemangiopericytoma10.1MDM2, S100A1
48myxoid liposarcoma10.1MDM2, CDK4
49alveolar rhabdomyosarcoma10.1CDK4, MDM2
50chondroblastoma10.1

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Symptoms for Chondroma

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Drugs & Therapeutics for Chondroma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Chondroma

Search CenterWatch for Chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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34MalaCards
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MalaCards organs/tissues related to Chondroma:

34
Tongue, Bone, Lung, Cortex, Spinal cord, Trachea, Occipital lobe, Testis, Prostate, Breast, Thyroid, Liver, Heart, Pituitary

Animal Models for Chondroma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chondroma:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
2MP:00053718.7RUNX2, PDGFRA, HMGA2, GLI1, MDM2, CTNNB1
3MP:00030128.6RUNX2, SDHB, PDGFRA, GLI1, MDM2, CTNNB1
4MP:00053678.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA
5MP:00053818.5RUNX2, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
6MP:00053808.5SDHD, PDGFRA, GLI1, MDM2, CDK4, CTNNB1
7MP:00053828.5RUNX2, PDGFRA, HMGA2, MDM2, CTNNB1
8MP:00053798.5RUNX2, SDHD, PDGFRA, HMGA2, GLI1, CDK4
9MP:00107718.4RUNX2, PDGFRA, HMGA2, MDM2, CDK4, CTNNB1
10MP:00053698.2RUNX2, PDGFRA, S100A1, MDM2, CDK4, CTNNB1
11MP:00036318.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
12MP:00053858.0RUNX2, SDHD, PDGFRA, S100A1, MDM2, CDK4
13MP:00053788.0RUNX2, SDHD, PDGFRA, HMGA2, GLI1, MDM2
14MP:00053868.0SDHD, PDGFRA, S100A1, HMGA2, GLI1, MDM2
15MP:00028737.9SDHD, PDGFRA, S100A1, GLI1, MDM2, CTNNB1
16MP:00053897.7CTNNB1, RUNX2, LPP, PDGFRA, HMGA2, GLI1
17MP:00053847.7RUNX2, SDHD, LPP, PDGFRA, GLI1, MDM2
18MP:00053767.5RUNX2, IDH1, SDHD, LPP, PDGFRA, HMGA2
19MP:00107687.4RUNX2, SDHD, SDHC, LPP, PDGFRA, GLI1

Publications for Chondroma

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53PubMed
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Articles related to Chondroma:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Chondroma located in cerebral parenchyma without meningeal attachment. (23172440)
2012
2
Extraskeletal chondroma in the auricle. (21119479)
2010
3
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
4
Massive chondroma of pelvis - case report. (19828919)
2009
5
Atypical location of a solitary intracranial chondroma without meningeal attachment. (17614089)
2007
6
Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. (18043038)
2007
7
Cutaneous chondroma with overlying pigmentation clinically mimicking dermatofibroma. (16403116)
2006
8
Intracortical chondroma: a report of two cases. (16284766)
2006
9
Nasal septum chondroma: a case report. (15875440)
2005
10
Laparoscopic presentation of a rib chondroma. (14676003)
2004
11
Soft-tissue chondroma in a finger: a case report. (12152379)
2002
12
Soft-tissue chondroma in the thumb. (12409791)
2002
13
Periosteal chondroma presenting as a subcutaneous mass in the thumb. (11733159)
2001
14
DNA flow cytometric analysis of chest-wall chondroma and chondrosarcoma. (8976036)
1996
15
Extraskeletal chondroma of the foot. (8867554)
1996
16
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. (7785598)
1995
17
Soft tissue chondroma of the fallopian tube. Differential diagnosis and histogenetic considerations. (7567687)
1995
18
Cardiac valvular chondroma. (7979695)
1994
19
Skull base chondroma of extracranial origin. (7822182)
1994
20
Soft-tissue chondroma as a cause of calcinosis in a patient with CREST syndrome. (8457459)
1993
21
Chondroma of the cervical spinal canal. Case report. (1306207)
1992
22
Benign cartilaginous tumor (chondroma) of the liver. (1634084)
1992
23
Intra-tendinous chondroma of a flexor tendon. (1779169)
1991
24
Chondroma of the lumbar spine, a rare cause of sciatica: case report. (2330093)
1990
25
Ossifying parasellar chondroma. Case report. (3117983)
1987
26
Chondroma of the nasal cavity and nasopharynx--a case of chondroma arising from the nasal septum. (3449038)
1987
27
Chondroma of falx: CT findings. (3782554)
1986
28
Case report 354: Chondroma of soft tissues with dystrophic calcification. (3961527)
1986
29
Extraskeletal ossifying chondroma in the knee. A case report. (3984711)
1985
30
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984
31
Malignant chondroma. (6582165)
1983
32
Orbital chondroma rodens in a dog. (500440)
1979
33
Intracerebral chondroma. (483149)
1979
34
The nasal chondroma. 2 case reports and a survey of the literature. (864317)
1977
35
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. 3. Cartilaginous tumors (chondroma, chondrosarcoma). (4853358)
1974
36
Periosteal chondroma. (4506239)
1972
37
Intracranial solitary chondroma of dural origin. (5459528)
1970
38
Chondroma of the tongue. (5267622)
1970
39
Case reports and technical notes. Chondroma of the cervical spine. Case report. (5684408)
1968
40
AN EXCEPTIONALLY LARGE CHONDROMA OF THE MAXILLA: CASE REPORT. (14256819)
1965
41
Chondroma of sternum. A case report. (14441200)
1959
42
Chondroma of the larynx; report of a case with recurrence after twenty-eight years. (13636589)
1959
43
An endobronchial chondroma in a cachectic psychotic with hypopituitarism. (13253916)
1955
44
Chondroma of the vocal cord. (15412306)
1950
45
Chondroma of the larynx; report of a case. (15393512)
1949
46
Laryngeal chondroma. (18892972)
1948
47
Chondroma of the larynx; report of a case. (18921039)
1948
48
Chondroma of right knee]. (20280022)
1947
49
Chondroma of eighth costal cartilage]. (21001781)
1946
50
Osteofibro-chondroma of the scapula in a new born infant. (20275903)
1946

Variations for Chondroma

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Expression for genes affiliated with Chondroma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 61Thomson Reuters, 56Reactome, 62Tocris Bioscience, 52PharmGKB, 54QIAGEN
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Pathways related to Chondroma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SDHA, IDH1, IDH2
2
Show member pathways
Alzheimers Disease39
9.5SDHA, SDHC, SDHD, SDHB
39.5MDM2, HMGA2, RUNX2
49.4CDK4, MDM2, PDGFRA
59.3MDM2, CDK4, CTNNB1
69.3CTNNB1, CDK4, MDM2
79.3RUNX2, CDK4, CTNNB1
8
Show member pathways
9.3IDH2, SDHB, SDHD, SDHC, SDHA
99.2CTNNB1, MDM2, RUNX2
10
Show member pathways
9.2PDGFRA, MDM2, CTNNB1
11
Show member pathways
TCA cycle39
pyruvate decarboxylation to acetyl CoA39
NAD phosphorylation and dephosphorylation39
TCA Cycle39
conversion of glucose to acetyl CoA and entry into the TCA cycle39
9.0SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
12
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.0IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
13
Show member pathways
Signaling Pathways in Glioblastoma39
8.9PDGFRA, MDM2, CDK4, CTNNB1
148.9CTNNB1, CDK4, MDM2, PDGFRA
158.9CTNNB1, CDK4, MDM2, PDGFRA
168.6PDGFRA, GLI1, MDM2, CDK4, CTNNB1

Compounds for genes affiliated with Chondroma

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25HMDB, 46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid2510.3IDH1, IDH2
2fumarate46 1211.2SDHC, SDHD, SDHB
3thenoyltrifluoroacetone46 1211.2SDHB, SDHA
4Isocitric acid25 1211.2IDH2, IDH1
5isocitrate4610.1IDH2, IDH1, SDHB
6Fumaric acid2510.0SDHB, SDHD, SDHC, SDHA
7succinic acid30 25 1212.0SDHB, SDHD, SDHC, SDHA
8iron-sulfur4610.0SDHB, SDHD, SDHC, SDHA
9ubiquinone4610.0SDHB, SDHD, SDHC, SDHA
10Sulfide2510.0SDHB, SDHD, SDHC, SDHA
11QH2259.9SDHB, SDHD, SDHC, SDHA
12Ubiquinone Q2259.9SDHA, SDHC, SDHD, SDHB
13Ubiquinone Q1259.9SDHB, SDHD, SDHC, SDHA
14succinate469.9SDHB, SDHD, SDHC, SDHA
15FAD259.9SDHA, SDHC, SDHD, SDHB
16cyclopamine46 6210.7CTNNB1, GLI1
17nad+469.7SDHB, SDHA, MDM2
18glyceraldehyde 3-phosphate469.7IDH1, SDHB, SDHA, MDM2
19somatropin recombinant52 1210.6TSPAN31, CDK4
20trastuzumab46 52 1211.6CTNNB1, CDK4, MDM2
21gefitinib46 52 1211.5CTNNB1, CDK4, MDM2
22adpribose469.5CTNNB1, CDK4, MDM2
23geldanamycin46 52 62 1212.4CTNNB1, CDK4, MDM2
24roscovitine469.3CTNNB1, CDK4, MDM2, RUNX2
25leptomycin b46 6210.3LPP, MDM2, CTNNB1
26valproic acid46 52 25 1212.3CTNNB1, CDK4, RUNX2
27tgf beta1469.2RUNX2, PDGFRA, CDK4, CTNNB1
28rapamycin469.1PDGFRA, MDM2, CDK4, CTNNB1
29ly294002469.1RUNX2, MDM2, CDK4, CTNNB1
30pd 98,059469.1RUNX2, GLI1, MDM2, CDK4, CTNNB1
31doxorubicin46 52 1210.9CTNNB1, CDK4, MDM2, HMGA2
32glycogen46 259.9SDHB, S100A1, MDM2, CDK4, CTNNB1
33dexamethasone46 52 30 1211.9RUNX2, SERPINA3, MDM2, CDK4, CTNNB1
34steroid468.9RUNX2, SDHC, SERPINA3, MDM2, CDK4, CTNNB1
35thymidine46 259.9RUNX2, PDGFRA, MDM2, CDK4, CTNNB1
36progesterone46 30 62 25 1212.8CTNNB1, CDK4, MDM2, S100A1, SERPINA3
37alanine468.8RUNX2, SDHB, SERPINA3, MDM2, CDK4, CTNNB1
38oxygen46 259.7RUNX2, SDHB, SDHD, SDHC, SDHA, SERPINA3
39oligonucleotide468.7RUNX2, SERPINA3, PDGFRA, MDM2, CDK4, CTNNB1
40cysteine468.7SDHB, SERPINA3, S100A1, MDM2, CDK4, CTNNB1
41zinc46 259.6RUNX2, SDHB, SERPINA3, S100A1, GLI1, MDM2
42phosphatidylinositol468.6CTNNB1, CDK4, MDM2, GLI1, PDGFRA, RUNX2
43iron46 259.6CDK4, SDHB, SDHD, SDHC, SDHA, SERPINA3
44arginine468.6SDHB, SERPINA3, MDM2, CDK4, CTNNB1
45vegf468.5RUNX2, SDHB, SDHC, PDGFRA, MDM2, CDK4
46paraffin468.4SERPINA3, PDGFRA, S100A1, HMGA2, MDM2, CDK4
47estrogen468.2RUNX2, SERPINA3, PDGFRA, S100A1, MDM2, CDK4
48calcium46 52 25 1211.1RUNX2, IDH1, SDHB, SERPINA3, PDGFRA, S100A1
49retinoic acid46 259.1RUNX2, SDHC, SERPINA3, PDGFRA, S100A1, HMGA2
50tyrosine468.0RUNX2, SDHB, PDGFRA, S100A1, MDM2, CDK4

GO Terms for genes affiliated with Chondroma

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17Gene Ontology
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Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7CTNNB1, HMGA2
2mitochondrial respiratory chain complex IIGO:0057499.6SDHA, SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:0057439.3IDH2, SDHB, SDHD, SDHC, SDHA
4mitochondrionGO:0057398.9IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
5nucleusGO:0056346.4RUNX2, SERPINA3, LPP, PDGFRA, S100A1, HMGA2

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.2IDH1, IDH2
2succinate metabolic processGO:00610510.2SDHA, SDHB
3isocitrate metabolic processGO:00610210.2IDH2, IDH1
4aerobic respirationGO:00906010.2SDHB, SDHC
52-oxoglutarate metabolic processGO:00610310.2IDH1, IDH2
6stem cell differentiationGO:04886310.1RUNX2, HMGA2
7negative regulation of cell cycle arrestGO:07115710.1CDK4, MDM2
8adrenal gland developmentGO:0303259.9HMGA2, PDGFRA
9respiratory electron transport chainGO:0229049.8SDHB, SDHD, SDHC, SDHA
10proximal/distal pattern formationGO:0099549.8CTNNB1, GLI1
11male genitalia developmentGO:0305399.7CTNNB1, PDGFRA
12pituitary gland developmentGO:0219839.7HMGA2, GLI1
13embryonic cranial skeleton morphogenesisGO:0487019.6PDGFRA, RUNX2
14cellular metabolic processGO:0442379.6IDH2, SDHB, SDHD, SDHC, SDHA
15odontogenesis of dentin-containing toothGO:0424759.5CTNNB1, PDGFRA, RUNX2
16tricarboxylic acid cycleGO:0060999.3SDHA, SDHC, SDHD, SDHB, IDH1, IDH2
17small molecule metabolic processGO:0442819.2IDH2, IDH1, SDHB, SDHD, SDHC, SDHA
18negative regulation of transcription, DNA-templatedGO:0458929.2CTNNB1, MDM2, HMGA2, RUNX2
19positive regulation of transcription, DNA-templatedGO:0458939.1RUNX2, HMGA2, GLI1, CTNNB1
20negative regulation of transcription from RNA polymerase II promoterGO:0001228.8CTNNB1, MDM2, HMGA2, S100A1
21positive regulation of cell proliferationGO:0082848.3RUNX2, TSPAN31, PDGFRA, GLI1, MDM2, CDK4

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00817710.1SDHB, SDHA
2isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
3ubiquinone bindingGO:04803910.0SDHB, SDHD
4succinate dehydrogenase activityGO:0001049.9SDHA, SDHC, SDHD
5repressing transcription factor bindingGO:0704919.6CTNNB1, RUNX2
6electron carrier activityGO:0090559.5SDHC, SDHD, SDHB
7protein bindingGO:0055156.1RUNX2, SDHB, SDHA, SERPINA3, LPP, PDGFRA

Products for genes affiliated with Chondroma

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Sources for Chondroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet