MCID: CHN010
MIFTS: 55

Chondroma malady

Summaries for Chondroma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. more...

MalaCards: Chondroma, also known as central chondroma, is related to chondrosarcoma and paraganglioma. An important gene associated with Chondroma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Pyruvate metabolism. The compounds cycloheximide and fumarate have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and lung, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Aliases & Classifications for Chondroma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

chondroma 8 42 10 44 60
central chondroma 8
chondroma nos 8


External Ids:

Disease Ontology8 DOID:2602
NCIt39 C53459
MeSH34 D002812

Related Diseases for Chondroma

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17GeneCards, 18GeneDecks
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Diseases related to Chondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.6SERPINA3, PTHLH, HMGA2, CDK4, MDM2, PDGFRA
2paraganglioma30.6IDH2, S100A1, KIT, SDHD, SDHB, SDHC
3leiomyosarcoma30.4KIT, CDK4, MDM2, PDGFRA, S100A1
4chondroblastoma30.0PTHLH
5meningioma30.0S100A1
6chordoma30.0PDGFRA, S100A1
7sarcoma30.0S100A1, PDGFRA, MDM2, HMGA2, KIT, CDK4
8pituitary adenoma29.8HMGA2, CDK4
9glomus tumor29.8SDHB, SDHD, S100A1
10fibrosarcoma29.8PDGFRA, MDM2
11gastrointestinal stromal tumor29.8PDGFRA, KIT
12adenoma29.8HMGA2, CDK4, CTNNB1, S100A1
13carney triad29.8SDHC, SDHB, SDHD, KIT, PDGFRA
14leiomyoma29.8S100A1, PDGFRA, KIT, HMGA2
15astrocytoma29.8IDH1, PDGFRA, MDM2, CDK4, SERPINA3
16lipoma29.7HMGA2, CDK4, LPP, MDM2, S100A1, LHFP
17squamous cell carcinoma29.7S100A1, PDGFRA, CTNNB1, MDM2, GLI1, CDK4
18periostitis10.8
19extraskeletal chondroma10.6
20juxtacortical chondroma10.5
21laryngitis10.5
22cervicitis10.3
23gastric leiomyosarcoma10.2
24meningitis10.2
25periosteal chondrosarcoma10.2
26central nervous system chondroma10.1
27asthma10.1
28radiculopathy10.0
29carpal tunnel syndrome10.0
30epithelioid leiomyosarcoma10.0
31mesenchymal chondrosarcoma10.0
32carpotarsal osteochondromatosis10.0
33ollier disease10.0PTHLH
34gliosarcoma10.0CDK4
35arthritis10.0SERPINA3
36dermatofibrosarcoma10.0MDM2
37basal cell carcinoma10.0GLI1
38renal oncocytoma10.0S100A1
39seminal vesicle tumor10.0SDHA
40cervical cancer10.0MDM2
41acute leukemia10.0KIT
42pheochromocytoma10.0SDHD, SDHB
43craniopharyngioma10.0CTNNB1
44uterine carcinosarcoma10.0KIT
45hereditary paraganglioma-pheochromocytoma syndromes10.0SDHD, SDHB, SDHC
46von hippel-lindau disease10.0SDHC, SDHB, SDHD
47hemangioma10.0SDHC, SDHB, SDHD
48paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
49carotid body tumor10.0SDHD, SDHB, SDHC
50thymus cancer10.0KIT

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to chondroma

Clinical Features for Chondroma

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Drugs & Therapeutics for Chondroma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chondroma

Drug clinical trials:

Search ClinicalTrials for Chondroma

Search NIH Clinical Center for Chondroma

Search CenterWatch for Chondroma

Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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32MalaCards
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MalaCards organs/tissues related to Chondroma:

32
Tongue, Bone, Lung, Cortex, Spinal cord, Trachea, Occipital lobe, Testis, Prostate, Breast, Thyroid, Liver, Heart, Pituitary

Animal Models for Chondroma or affiliated genes

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36MGI
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Publications for Chondroma

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50PubMed
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Articles related to Chondroma:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Compression of the digital nerves by a giant periosteal chondroma. (23245470)
2013
2
Soft tissue chondroma of the index finger: clinical, histological and radiological findings in a unique case. (24011276)
2013
3
Soft tissue chondroma of hard palate associated with cleft palate. (23450263)
2012
4
Chondroma in temporomandibular region--case report and therapeutic considerations. (21072549)
2012
5
Stridor as initial clinical presentation of tracheal chondroma. (20346431)
2011
6
Extraskeletal juxtaarticular chondroma of the knee. (21610313)
2011
7
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
8
A true chondroma cutis. (19415816)
2009
9
Giant cystic intracranial chondroma of the falx with review of literature. (18761633)
2009
10
Five cases of chondroma involving the external auditory canal. (18242908)
2008
11
Juxtacortical chondroma of the sacrum. (18843465)
2008
12
Orbital chondroma. (17117112)
2006
13
Recurrent para-articular chondroma of the ankle: a case report. (16539906)
2006
14
A case of congenital soft tissue chondroma. (15863870)
2005
15
Chondroma of the cheek: A case report. (15955665)
2005
16
Resolution of chylothorax after resection of rib chondroma in a dog. (14692553)
2003
17
Chondroma in the bony external ear canal. (12405083)
2002
18
Periosteal chondroma of the distal radius. (10672819)
1999
19
Chondroma of the trachea. (9810461)
1998
20
Chondroma of the bladder. (9532011)
1998
21
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. (7785598)
1995
22
Immunohistochemical study on collagenous proteins and biophysical analysis of crystals in extraskeletal chondroma. (7496505)
1995
23
Cardiac valvular chondroma. (7979695)
1994
24
Pathologic quiz case 2. Chondroma of the larynx. (17436440)
1993
25
Gastric leiomyoblastoma associated with extraadrenal paraganglioma and pulmonary chondroma: a new case of Carney's triad. (8301486)
1993
26
Chondroma of the cervical spine. (3197353)
1988
27
Periosteal chondroma. (3809014)
1987
28
Tenosynovial chondroma of the hand. (4078480)
1985
29
Chondroma of the skull base. A case report. (6822775)
1983
30
Intradural chondroma: a case report and review of the literature. (6828215)
1983
31
Resection of bronchial chondroma through the flexible fiberoptic bronchoscope. (7363872)
1980
32
Intracranial solitary chondroma. Case report. (682012)
1978
33
Tenosynovial chondroma of the hand: a case report with a brief review of the literature. (711227)
1978
34
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. 3. Cartilaginous tumors (chondroma, chondrosarcoma). (4853358)
1974
35
Chondroma of the tongue. (4519447)
1974
36
Synovial chondromatosis of the knee with associated extracapsular chondromas. (4804995)
1973
37
Periosteal chondroma. (4506239)
1972
38
Carpal chondroma. Report of a case. (5121801)
1971
39
Parajugular foramen chondroma. Case report. (5659578)
1968
40
Cartilage-containing tumours of the lung. Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours. (6033393)
1967
41
Periosteal chondroma (juxtacortical chondroma). (5889127)
1964
42
PERIOSTEAL CHONDROMA. REPORT OF AN ATYPICAL CASE AND REVIEW O THE LITERATURE. (14166219)
1964
43
Juxtacortical chondroma. (13499868)
1958
44
Chondroma of the arytenoid. (13481481)
1957
45
Periosteal myxoma of infancy and periosteal chondroma of adolescence, with local malignancy. (13447244)
1957
46
Chondroma in infrapatellar fat pad. (14890911)
1951
47
Laryngeal chondroma. (18892972)
1948
48
Laryngeal chondroma. (20243500)
1947
49
Recurrent Chondroma of the Subglottic Region. (19993542)
1947
50
A CASE OF CHONDROMA BULBI. (18170246)
1946

Genetic Variations for Chondroma

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Expression for genes affiliated with Chondroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for genes affiliated with Chondroma

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12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Chondroma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Chondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5RUNX2
2fumarate44 1111.2SDHC, SDHB, SDHD
3UBIQUINONE-11110.0SDHB, SDHC, SDHD, SDHA
42-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHA, SDHC, SDHB, SDHD
5isocitrate4410.0IDH1, IDH2, SDHB
6succinic acid28 11 2412.0SDHA, SDHC, SDHB, SDHD
7iron-sulfur4410.0SDHB, SDHD, SDHC, SDHA
8ubiquinone4410.0SDHB, SDHA, SDHC, SDHD
9naphthol as-d chloroacetate4410.0KIT, SERPINA3
10succinate4410.0SDHD, SDHB, SDHA, SDHC
11thenoyltrifluoroacetone44 1111.0SDHA, SDHB
12ag-1296449.8PTHLH, PDGFRA, KIT
13somatropin recombinant49 1110.7CDK4, TSPAN31
14paclitaxel44 49 1111.6CDK4, MDM2, CTNNB1
15lead449.5PTHLH, MDM2, CDK4, KIT
16dexamethasone44 49 28 1112.5MDM2, CDK4, CTNNB1
17glucose449.5GLI1, SERPINA3, SDHB, RUNX2, PTHLH
18glyceraldehyde 3-phosphate449.5SDHA, IDH1, SDHB, MDM2
19valine449.4MDM2, KIT, PTHLH, SERPINA3, CDK4
20roscovitine449.4CDK4, CTNNB1, RUNX2, MDM2
21leptomycin b44 5910.3CTNNB1, LPP, PTHLH, MDM2
22trastuzumab44 49 1111.3CTNNB1, MDM2, CDK4, KIT
23steroid449.3CDK4, PTHLH, SERPINA3, SDHC, RUNX2, MDM2
24gefitinib44 49 1111.3MDM2, KIT, CDK4, CTNNB1
25geldanamycin44 49 59 1112.3KIT, MDM2, CTNNB1, CDK4
26tgf beta1449.1CDK4, PTHLH, CTNNB1, PDGFRA, RUNX2
27imatinib44 49 1111.1KIT, CTNNB1, PDGFRA, MDM2
28doxorubicin44 49 1111.0KIT, HMGA2, MDM2, CDK4, CTNNB1
29arginine448.9CTNNB1, SERPINA3, SDHB, MDM2, PTHLH, CDK4
30rapamycin448.9PDGFRA, CDK4, KIT, MDM2, CTNNB1
31testosterone44 59 11 2411.8MDM2, CDK4, KIT, CTNNB1, SDHB, PTHLH
32pd 98,059448.7MDM2, GLI1, CDK4, CTNNB1, KIT, RUNX2
33alanine448.7RUNX2, PTHLH, SDHB, SERPINA3, CDK4, MDM2
34oxygen44 249.6SDHD, RUNX2, CDK4, PTHLH, SDHC, SDHA
35cisplatin44 49 59 1111.6CTNNB1, MDM2, CDK4, HMGA2, PTHLH
36thymidine44 249.4KIT, CDK4, MDM2, CTNNB1, PDGFRA, RUNX2
37iron44 249.4CDK4, SDHA, SDHC, SDHB, SDHD, S100A1
38threonine448.4PTHLH, MDM2, CDK4, KIT, CTNNB1, SERPINA3
39zinc44 249.4SDHB, RUNX2, S100A1, MDM2, GLI1, CDK4
40oligonucleotide448.4SERPINA3, MDM2, CTNNB1, KIT, PDGFRA, RUNX2
41phosphatidylinositol448.1KIT, GLI1, MDM2, CTNNB1, PDGFRA, RUNX2
42glycogen44 249.1MDM2, CTNNB1, S100A1, PTHLH, CDK4, KIT
43progesterone44 59 28 11 2412.1MDM2, CTNNB1, KIT, CDK4, SERPINA3, S100A1
44nitric oxide44 11 2410.0PTHLH, KIT, MDM2, CDK4, S100A1, RUNX2
45vegf448.0PDGFRA, RUNX2, CDK4, KIT, PTHLH, SDHB
46cysteine447.9CTNNB1, S100A1, MDM2, CDK4, SERPINA3, SDHB
47paraffin447.5CTNNB1, PDGFRA, S100A1, KIT, MDM2, CDK4
48calcium44 49 11 2410.3MDM2, KIT, PDGFRA, S100A1, RUNX2, CDK4
49retinoic acid44 248.3S100A1, PDGFRA, SDHC, SERPINA3, PTHLH, HMGA2
50tyrosine447.3CTNNB1, RUNX2, SDHB, PTHLH, KIT, CDK4

GO Terms for genes affiliated with Chondroma

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16Gene Ontology
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Cellular components related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.7HMGA2, CTNNB1
2mitochondrial respiratory chain complex IIGO:0057499.6SDHD, SDHB, SDHC, SDHA
3mitochondrial inner membraneGO:0057439.2IDH2, SDHA, SDHD, SDHB, SDHC
4nucleusGO:0056345.7SERPINA3, RUNX2, S100A1, PTHLH, HMGA2, KIT

Biological processes related to Chondroma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.1IDH2, IDH1
2isocitrate metabolic processGO:00610210.0IDH2, IDH1
3respiratory electron transport chainGO:0229049.7SDHA, SDHC, SDHB, SDHD
4negative regulation of chondrocyte differentiationGO:0323319.7CTNNB1, PTHLH
5stem cell differentiationGO:0488639.7HMGA2, KIT, RUNX2
6succinate metabolic processGO:0061059.7SDHB, SDHA
7positive regulation of phospholipase C activityGO:0108639.6KIT, PDGFRA
8cellular metabolic processGO:0442379.5SDHC, SDHB, SDHD, IDH2, SDHA
9tricarboxylic acid cycleGO:0060999.3IDH1, IDH2, SDHD, SDHB, SDHC, SDHA
10odontogenesis of dentin-containing toothGO:0424759.2RUNX2, PDGFRA, CTNNB1
11positive regulation of cell proliferationGO:0082847.9PTHLH, TSPAN31, CDK4, GLI1, MDM2, PDGFRA

Molecular functions related to Chondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
2succinate dehydrogenase (ubiquinone) activityGO:0081779.9SDHB, SDHA
3ubiquinone bindingGO:0480399.8SDHB, SDHD
4protein bindingGO:0055155.8KIT, SDHA, SDHB, SERPINA3, RUNX2, S100A1

Products for genes affiliated with Chondroma

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Sources for Chondroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet