MCID: CHN053
MIFTS: 41

Chondromyxoid Fibroma

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Chondromyxoid Fibroma

MalaCards integrated aliases for Chondromyxoid Fibroma:

Name: Chondromyxoid Fibroma 55 69
Fibroma Chondromyxoid 51

Characteristics:

Orphanet epidemiological data:

55
chondromyxoid fibroma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 55  
Rare bone diseases


External Ids:

Orphanet 55 ORPHA404507
UMLS via Orphanet 70 C0221290
ICD10 via Orphanet 33 D16.9
UMLS 69 C0221290

Summaries for Chondromyxoid Fibroma

MalaCards based summary : Chondromyxoid Fibroma, also known as fibroma chondromyxoid, is related to mesenchymal chondrosarcoma and ovarian fibrothecoma, and has symptoms including pain An important gene associated with Chondromyxoid Fibroma is GRM1 (Glutamate Metabotropic Receptor 1), and among its related pathways/superpathways are ERK Signaling and Endometrial cancer. Affiliated tissues include bone and cortex, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Chondromyxoid fibroma is a type of cartilaginous... more...

Related Diseases for Chondromyxoid Fibroma

Diseases related to Chondromyxoid Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 mesenchymal chondrosarcoma 30.1 DES SOX9 VIM
2 ovarian fibrothecoma 10.5 ACTC1 DES
3 fibroblastic rheumatism 10.5 ACTC1 DES
4 tooth ankylosis 10.4 PTH1R PTHLH
5 chondroblastoma 10.4
6 plasma cell leukemia 10.4 CCND1 FGFR3
7 achondroplasia 10.4 FGFR3 PTH1R SOX9
8 metaphyseal chondrodysplasia, jansen type 10.4 FGFR3 PTH1R PTHLH
9 breast papillomatosis 10.4 CCND1 CDKN2A
10 bizarre leiomyoma 10.3 ACTC1 CDKN2A
11 pyle disease 10.3 COL10A1 PTH1R PTHLH
12 tonsil squamous cell carcinoma 10.3 CCND1 CDKN2A
13 lymphoma, small cleaved-cell, diffuse 10.3 BCL2 CCND1
14 lymphangiectasis 10.3 ACTC1 VIM
15 glomangiomyoma 10.3 ACTC1 VIM
16 dedifferentiated liposarcoma 10.3 ACTC1 CDKN2A DES
17 skin glomus tumor 10.2 DES VIM
18 intravascular papillary endothelial hyperplasia 10.2 ACTC1 VIM
19 bowenoid papulosis 10.2 CCND1 CDKN2A
20 skeletal dysplasias 10.2 FGFR3 PTH1R PTHLH SOX9
21 primary hyperparathyroidism 10.2 CCND1 PTH1R PTHLH
22 osteochondrodysplasia 10.2 FGFR3 PTH1R PTHLH SOX9
23 infantile digital fibromatosis 10.2 DES VIM
24 lymphangiomatosis 10.2 DES VIM
25 aneurysmal bone cysts 10.2
26 aneurysm 10.2
27 chondrosarcoma 10.2
28 skin carcinoma in situ 10.2 CCND1 CDKN2A
29 primitive neuroectodermal tumor of the cervix uteri 10.2 DES VIM
30 endometrial squamous cell carcinoma 10.1 CCND1 CDKN2A
31 angiolipoma 10.1 ACTC1 DES VIM
32 cutaneous leiomyosarcoma 10.1 ACTC1 DES VIM
33 spindle cell lipoma 10.1 ACTC1 DES VIM
34 parachordoma 10.1 ACTC1 DES VIM
35 ossifying fibromyxoid tumor 10.1 ACTC1 DES VIM
36 epithelioid leiomyosarcoma 10.1 ACTC1 DES VIM
37 syringocystadenoma papilliferum 10.1 ACTC1 DES VIM
38 congenital fibrosarcoma 10.1 ACTC1 DES VIM
39 perivascular epithelioid cell tumor 10.1 ACTC1 DES VIM
40 cutaneous fibrous histiocytoma 10.1 ACTC1 DES VIM
41 epulis 10.1 DES VIM
42 peyronie disease 10.1 DES TGFB1
43 keratocystic odontogenic tumor 10.1 BCL2 CCND1 PTHLH
44 spindle cell sarcoma 10.1 ACTC1 DES VIM
45 pseudosarcomatous fibromatosis 10.1 ACTC1 DES VIM
46 glomus tumor 10.1 ACTC1 DES VIM
47 infantile myofibromatosis 10.1 ACTC1 DES VIM
48 smooth muscle tumor 10.1 ACTC1 DES VIM
49 hemangiopericytoma, malignant 10.1 ACTC1 DES VIM
50 malignant fibroxanthoma 10.1 ACTC1 DES VIM

Graphical network of the top 20 diseases related to Chondromyxoid Fibroma:



Diseases related to Chondromyxoid Fibroma

Symptoms & Phenotypes for Chondromyxoid Fibroma

UMLS symptoms related to Chondromyxoid Fibroma:


pain

MGI Mouse Phenotypes related to Chondromyxoid Fibroma:

43 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2 cellular MP:0005384 10.46 COL10A1 COL12A1 DES FGFR3 GRM1 PTHLH
3 cardiovascular system MP:0005385 10.4 S100A1 SERPINE1 SOX9 TGFB1 VIM ACTC1
4 homeostasis/metabolism MP:0005376 10.4 TGFB1 VIM ACTC1 BCL2 CCND1 CDKN1A
5 growth/size/body region MP:0005378 10.39 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
6 mortality/aging MP:0010768 10.36 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
7 hematopoietic system MP:0005397 10.31 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
8 immune system MP:0005387 10.29 SOX9 TGFB1 VIM BCL2 CCND1 CDKN1A
9 craniofacial MP:0005382 10.23 COL10A1 FGFR3 PTH1R PTHLH SOX9 TGFB1
10 digestive/alimentary MP:0005381 10.22 CDKN1A CDKN2A FGFR3 PTH1R PTHLH SOX9
11 endocrine/exocrine gland MP:0005379 10.21 BCL2 CCND1 CDKN1A CDKN2A COL10A1 PTH1R
12 integument MP:0010771 10.19 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
13 muscle MP:0005369 10.17 S100A1 SOX9 TGFB1 VIM ACTC1 BCL2
14 adipose tissue MP:0005375 10.15 SERPINE1 SOX9 TGFB1 CDKN1A GRM1 PTHLH
15 nervous system MP:0003631 10.15 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
16 neoplasm MP:0002006 10.06 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
17 limbs/digits/tail MP:0005371 10.02 CDKN1A COL10A1 COL12A1 FGFR3 PTH1R PTHLH
18 reproductive system MP:0005389 9.96 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
19 renal/urinary system MP:0005367 9.92 GRM1 PTHLH SERPINE1 SOX9 TGFB1 BCL2
20 respiratory system MP:0005388 9.9 CCND1 CDKN1A CDKN2A FGFR3 PTH1R PTHLH
21 skeleton MP:0005390 9.7 CCND1 CDKN1A CDKN2A COL10A1 COL12A1 FGFR3
22 vision/eye MP:0005391 9.36 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1

Drugs & Therapeutics for Chondromyxoid Fibroma

Search Clinical Trials , NIH Clinical Center for Chondromyxoid Fibroma

Genetic Tests for Chondromyxoid Fibroma

Anatomical Context for Chondromyxoid Fibroma

MalaCards organs/tissues related to Chondromyxoid Fibroma:

38
Bone, Cortex

Publications for Chondromyxoid Fibroma

Articles related to Chondromyxoid Fibroma:

(show top 50) (show all 70)
# Title Authors Year
1
Chondromyxoid Fibroma of the Metatarsal Bone: A Diagnosis Using Fine Needle Aspiration Biopsy. ( 29403178 )
2018
2
Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases. ( 29324473 )
2018
3
Benign Chondromyxoid Fibroma of the Iliac Crest. ( 29385939 )
2018
4
Chondromyxoid Fibroma of the Skull Base: Our Experience with an Elusive Disease. ( 28255973 )
2017
5
Primary Orbital Chondromyxoid Fibroma: A Rare Case. ( 28099230 )
2017
6
Chondromyxoid fibroma of the distal fibula treated by percutaneous radiofrequency ablation. ( 28731366 )
2017
7
Long-lasting chondromyxoid fibroma of the zygoma: A rare case report and review of literature. ( 28852667 )
2017
8
Radiological presentation of chondromyxoid fibroma in the sellar region: A CARE-compliant article and literature review. ( 29245307 )
2017
9
An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. ( 28808739 )
2017
10
Chondromyxoid fibroma of the sacrum: A case report and literature review. ( 27274412 )
2016
11
Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review. ( 26929898 )
2016
12
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016
13
Rare case of sacral mass due to chondromyxoid fibroma. ( 26961558 )
2016
14
Chondromyxoid fibroma of the pubic ramus: a case report and literature review. ( 26854059 )
2016
15
Imaging features of chondromyxoid fibroma: report of 15 cases and literature review. ( 27226218 )
2016
16
Pediatric Chondromyxoid Fibroma-Like Osteosarcoma. ( 27935335 )
2016
17
Chondromyxoid Fibroma of Radius: A Case Report. ( 27437232 )
2016
18
Chondromyxoid Fibroma: A Rare Case Report and Review of Literature. ( 27833828 )
2016
19
Chondromyxoid Fibroma of Two Cervical Vertebrae with Involvement of Surrounding Soft Tissue: Radiologic Diagnostic Dilemma. ( 26587204 )
2015
20
Chondromyxoid fibroma of zygoma in an elderly patient: A rare presentation. ( 26981481 )
2015
21
Chondromyxoid Fibroma: An Unusual Tumour at An Atypical Location. ( 26393192 )
2015
22
Chondromyxoid Fibroma of Pelvis, Surgical Management of 8 Cases. ( 26058932 )
2015
23
Chondromyxoid Fibroma of the Sternum in a 63-Year-Old Woman. ( 26413029 )
2015
24
Maxillary osteosarcoma masquerading as chondromyxoid fibroma: report of a case. ( 25838677 )
2015
25
Extradural spinal chondromyxoid fibroma mimicking intradural mass lesion: MR and MR myelographic images. ( 26235465 )
2015
26
Surgical management of a giant sternal chondromyxoid fibroma: a case report. ( 26615403 )
2015
27
Chondromyxoid fibroma of the frontal bone mimicking meningioma. ( 25748938 )
2015
28
Chondromyxoid fibroma invasion of the transverse-sigmoid sinus junction causing posterior fossa hemorrhage. ( 26481053 )
2015
29
Chondromyxoid fibroma; experience of 36 cases of an intriguing entity. ( 25989772 )
2014
30
A false positive finding on the PET of somatostatin receptor due to a chondromyxoid fibroma. ( 24140025 )
2014
31
Chondromyxoid Fibroma of the Mandible in an Adolescent: Case Report and Microsurgical Reconstructive Option. ( 24625223 )
2014
32
Surface chondromyxoid fibroma of the distal ulna: unusual tumor, site, and age. ( 24057439 )
2014
33
Chondromyxoid fibroma of the finger. ( 24883287 )
2014
34
Chondromyxoid fibroma of the mandible: Case report and review of the literature. ( 24987604 )
2014
35
Chondromyxoid fibroma of zygoma: A rare case report. ( 24959045 )
2014
36
Chondromyxoid fibroma management: a single institution experience of 22 cases. ( 25217119 )
2014
37
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. ( 24658000 )
2014
38
Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. ( 23630677 )
2013
39
Chondromyxoid fibroma of the second rib. ( 23845646 )
2013
40
Pseudotetraploid clone with structural chromosomal rearrangements in a chondromyxoid fibroma: a case report. ( 23282218 )
2013
41
Chondroblastoma and chondromyxoid fibroma. ( 23545728 )
2013
42
Chondromyxoid fibroma with secondary aneurysmal bone cyst of the rib. ( 22971709 )
2013
43
Huge chondromyxoid fibroma of proximal third tibia masquerading as an aneurysmal bone cyst: A rare case report. ( 24455535 )
2013
44
Chondromyxoid fibroma of the calcaneus: two case reports and literature review. ( 23590809 )
2013
45
Chondromyxoid fibroma of the mastoid portion of the temporal bone: MRI and PET/CT findings and their correlation with histology. ( 23599102 )
2013
46
Chondromyxoid fibroma of calcaneus. ( 23337277 )
2013
47
A rare case of chondromyxoid fibroma mimicking spina ventosa. ( 23066464 )
2012
48
Chondromyxoid fibroma of the temporal bone: A rare entity. ( 23560012 )
2012
49
Chondromyxoid fibroma of the clavicle extending to the adjacent joint: a case report. ( 23255657 )
2012
50
Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas. ( 22933546 )
2012

Variations for Chondromyxoid Fibroma

Copy number variations for Chondromyxoid Fibroma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 206032 6 135200000 139100000 Gain BCLAF1 Chondromyxoid Fibroma
2 215014 6 70000000 75900000 Gain COL12A1 Chondromyxoid Fibroma
3 215892 6 82700000 149100000 Deletion UTRN Chondromyxoid Fibroma

Expression for Chondromyxoid Fibroma

Search GEO for disease gene expression data for Chondromyxoid Fibroma.

Pathways for Chondromyxoid Fibroma

Pathways related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2
Show member pathways
12.98 BCL2 CCND1 CDKN1A CDKN2A FGFR3 TGFB1
3 12.74 BCL2 CCND1 CDKN1A CDKN2A FGFR3 TGFB1
4
Show member pathways
12.69 BCL2 CCND1 CDKN1A CDKN2A TGFB1
5
Show member pathways
12.48 BCL2 CCND1 CDKN1A CDKN2A GRM1 TGFB1
6 12.46 CCND1 CDKN1A CDKN2A VIM
7 12.38 CCND1 CDKN1A CDKN2A TGFB1
8 12.36 BCL2 CCND1 CDKN1A CDKN2A FGFR3 VIM
9
Show member pathways
12.32 CCND1 CDKN1A CDKN2A SERPINE1
10 12.31 CCND1 CDKN1A CDKN2A TGFB1
11
Show member pathways
12.28 CCND1 CDKN1A CDKN2A TGFB1
12
Show member pathways
12.17 BCL2 CCND1 CDKN1A FGFR3
13
Show member pathways
12.16 CCND1 CDKN1A CDKN2A TGFB1
14
Show member pathways
12.08 CCND1 CDKN1A CDKN2A TGFB1
15 12.06 CCND1 CDKN1A CDKN2A SERPINE1 TGFB1
16
Show member pathways
12.02 CCND1 CDKN1A GRM1 TGFB1
17 11.99 BCL2 CDKN1A CDKN2A TGFB1
18 11.99 BCL2 CDKN1A S100A2 SERPINE1
19 11.93 CCND1 SOX9 TGFB1 VIM
20 11.91 CCND1 CDKN1A CDKN2A
21 11.86 BCL2 CDKN1A SERPINE1
22 11.84 BCL2 CCND1 CDKN1A CDKN2A SERPINE1
23 11.83 DES SOX9 TGFB1
24 11.82 BCL2 CCND1 CDKN1A
25 11.82 BCL2 CCND1 SERPINE1 TGFB1
26 11.74 FGFR3 SOX9 VIM
27 11.73 BCL2 CCND1 CDKN1A
28 11.72 BCL2 CCND1 CDKN1A CDKN2A TGFB1
29 11.7 CDKN1A TGFB1 VIM
30 11.69 BCL2 CDKN1A CDKN2A
31 11.68 CDKN1A SERPINE1 TGFB1
32 11.67 ACTC1 DES VIM
33 11.66 CCND1 CDKN1A CDKN2A FGFR3
34 11.61 BCL2 CCND1 CDKN1A TGFB1 VIM
35 11.58 BCL2 CCND1 CDKN1A
36 11.48 CCND1 CDKN1A TGFB1
37 11.46 BCL2 CDKN1A CDKN2A COL10A1 SERPINE1 TGFB1
38 11.38 BCL2 CCND1 CDKN1A CDKN2A
39 11.35 CCND1 PTH1R PTHLH
40
Show member pathways
11.03 BCL2 CDKN1A CDKN2A
41 10.91 COL10A1 FGFR3 PTH1R PTHLH SOX9 TGFB1
42 10.88 BCL2 COL10A1 COL12A1 DES FGFR3 TGFB1
43 10.82 BCL2 TGFB1

GO Terms for Chondromyxoid Fibroma

Biological processes related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 ACTC1 CDKN2A SOX9 TGFB1 VIM
2 response to drug GO:0042493 9.83 ACTC1 BCL2 CCND1 CDKN1A TGFB1
3 positive regulation of cell proliferation GO:0008284 9.8 BCL2 CCND1 FGFR3 PTH1R PTHLH SOX9
4 G1/S transition of mitotic cell cycle GO:0000082 9.77 CCND1 CDKN1A CDKN2A
5 cellular calcium ion homeostasis GO:0006874 9.77 BCL2 PTH1R TGFB1
6 female pregnancy GO:0007565 9.76 BCL2 PTHLH TGFB1
7 response to organic substance GO:0010033 9.75 CCND1 CDKN1A TGFB1
8 ossification GO:0001503 9.74 BCL2 PTH1R SOX9
9 response to glucocorticoid GO:0051384 9.72 BCL2 CCND1 CDKN1A
10 negative regulation of cell growth GO:0030308 9.71 BCL2 CDKN1A CDKN2A TGFB1
11 protein kinase B signaling GO:0043491 9.69 CDKN1A SOX9 TGFB1
12 animal organ regeneration GO:0031100 9.67 CCND1 CDKN1A TGFB1
13 muscle filament sliding GO:0030049 9.63 ACTC1 DES VIM
14 intermediate filament organization GO:0045109 9.62 DES VIM
15 osteoblast development GO:0002076 9.61 PTH1R PTHLH
16 response to corticosterone GO:0051412 9.61 CCND1 CDKN1A
17 negative regulation of epithelial cell differentiation GO:0030857 9.56 CCND1 SOX9
18 heart valve morphogenesis GO:0003179 9.54 SOX9 TGFB1
19 negative regulation of ossification GO:0030279 9.54 BCL2 SOX9 TGFB1
20 replicative senescence GO:0090399 9.5 CDKN1A CDKN2A SERPINE1
21 negative regulation of cell proliferation GO:0008285 9.5 BCL2 CDKN1A CDKN2A PTH1R PTHLH SOX9
22 positive regulation of extracellular matrix assembly GO:1901203 9.48 SOX9 TGFB1
23 chondrocyte differentiation GO:0002062 9.46 FGFR3 PTH1R SOX9 TGFB1
24 skeletal system development GO:0001501 9.1 COL10A1 COL12A1 FGFR3 PTH1R PTHLH SOX9

Molecular functions related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BCL2 DES FGFR3 S100A1 S100A2 TGFB1
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1A CDKN2A

Sources for Chondromyxoid Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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