CHDSA
MCID: CHN012
MIFTS: 56

Chondrosarcoma (CHDSA) malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Chondrosarcoma

Aliases & Descriptions for Chondrosarcoma:

Name: Chondrosarcoma 54 12 50 56 66 29 13 52 42 14 69
Primary Chondrosarcoma of the Bone 12
Chondrosarcoma of Bone 12
Chdsa 66

Characteristics:

Orphanet epidemiological data:

56
chondrosarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Adult; Age of death: adult,elderly;

HPO:

32
chondrosarcoma:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 56  
Rare bone diseases


External Ids:

OMIM 54 215300
Disease Ontology 12 DOID:3371
MeSH 42 D002813
NCIt 47 C2946 C7155
Orphanet 56 ORPHA55880
MESH via Orphanet 43 D002813
UMLS via Orphanet 70 C0008479
ICD10 via Orphanet 34 C49.9
MedGen 40 C0008479

Summaries for Chondrosarcoma

UniProtKB/Swiss-Prot : 66 Chondrosarcoma: A malignant neoplasm derived from cartilage cells. Chondrosarcomas range from slow-growing non-metastasizing lesions to highly aggressive metastasizing sarcomas.

MalaCards based summary : Chondrosarcoma, also known as primary chondrosarcoma of the bone, is related to liposarcoma and mesenchymal chondrosarcoma. An important gene associated with Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related phenotype is skeleton.

Disease Ontology : 12 A connective tissue cancer that has material basis in cells derived from transformed cells that produce cartilage.

Wikipedia : 71 Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.... more...

Description from OMIM: 215300

Related Diseases for Chondrosarcoma

Diseases in the Chondrosarcoma family:

Localized Chondrosarcoma

Diseases related to Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
id Related Disease Score Top Affiliating Genes
1 liposarcoma 29.4 EWSR1 SPARC
2 mesenchymal chondrosarcoma 12.3
3 myxoid chondrosarcoma 12.2
4 chondrosarcoma, extraskeletal myxoid 12.1
5 extraosseous chondrosarcoma 12.1
6 bone chondrosarcoma 12.1
7 adult mesenchymal chondrosarcoma 12.0
8 adult myxoid chondrosarcoma 12.0
9 extraskeletal mesenchymal chondrosarcoma 12.0
10 clear cell chondrosarcoma 11.9
11 periosteal chondrosarcoma 11.9
12 localized chondrosarcoma 11.9
13 intracranial chondrosarcoma 11.9
14 juxtacortical chondrosarcoma 11.9
15 pediatric mesenchymal chondrosarcoma 11.7
16 pediatric myxoid chondrosarcoma 11.7
17 adult extraosseous chondrosarcoma 11.7
18 chondroid chordoma 11.1
19 bone cancer 10.7
20 multiple enchondromatosis, maffucci type 10.7
21 exostoses, multiple, type 1 10.7
22 exostoses, multiple, type 2 10.7
23 enchondroma 10.3
24 erythroderma, lethal congenital 10.3 EXT1 EXT2
25 ovarian large-cell neuroendocrine carcinoma 10.2 EWSR1 TAF15 TFG
26 trichorhinophalangeal syndrome, type ii 10.2 EXT1 EXT2
27 chordoma 10.2
28 periostitis 10.2
29 vulvar syringoma 10.2 EXT1 EXT2
30 sarcoma 10.2
31 transverse colon cancer 10.2 EWSR1 EXT1 PTHLH
32 macrosomia with microphthalmia, lethal 10.1 EXT1 EXT2 PTHLH
33 synovial chondromatosis 10.1
34 endocardium cancer 10.1 EWSR1 MTAP NR4A3 TAF15
35 cervicitis 10.1
36 osteochondroma 10.1
37 chondroma 10.1
38 colorectal cancer 1 10.1 ENO2 EWSR1 NR4A3 TAF15 TFG
39 malignant adult ependymoma 10.0 EXT2 PTHLH SPARC
40 binocular vision disease 10.0 PTHLH SPARC
41 laryngitis 10.0
42 bacterial vaginosis 10.0 EWSR1 SPARC
43 ovarian epithelial cancer 10.0 EXT1 EXT2 FGF2 PTHLH
44 gestational choriocarcinoma 10.0 ENO2 EWSR1 EXT1 FGF2
45 endotheliitis 10.0
46 exostosis 9.9
47 hereditary multiple exostoses 9.9
48 intrahepatic cholestasis 9.9 EWSR1 EXT1 MTAP PTHLH SPARC
49 meningitis 9.9
50 chondroblastoma 9.9

Graphical network of the top 20 diseases related to Chondrosarcoma:



Diseases related to Chondrosarcoma

Symptoms & Phenotypes for Chondrosarcoma

Symptoms by clinical synopsis from OMIM:

215300

Clinical features from OMIM:

215300

Human phenotypes related to Chondrosarcoma:

32
id Description HPO Frequency HPO Source Accession
1 chondrosarcoma 32 HP:0006765

MGI Mouse Phenotypes related to Chondrosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.28 EXT1 EXT2 FGF2 MMP13 PTHLH SOX9

Drugs & Therapeutics for Chondrosarcoma

Drugs for Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Cyproheptadine Approved Phase 3 129-03-3 2913
7
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
8
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
9
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
10 Alkylating Agents Phase 3,Phase 2
11 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
12 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
13 Antineoplastic Agents, Alkylating Phase 3,Phase 2
14 Isophosphamide mustard Phase 3,Phase 2
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Liver Extracts Phase 3,Phase 2,Phase 1
17 Adjuvants, Anesthesia Phase 3
18 Analgesics Phase 3,Phase 1,Phase 2
19 Analgesics, Opioid Phase 3
20 Anesthetics Phase 3
21 Anesthetics, General Phase 3
22 Anesthetics, Intravenous Phase 3
23 Central Nervous System Depressants Phase 3
24 Narcotics Phase 3
25 pancreatic polypeptide Phase 3
26 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
27 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
28 Anti-Allergic Agents Phase 3
29 Antipruritics Phase 3
30 Dermatologic Agents Phase 3
31 Histamine Antagonists Phase 3
32 Histamine H1 Antagonists Phase 3
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Neurotransmitter Agents Phase 3
35
Serotonin Phase 3 50-67-9 5202
36 Serotonin Agents Phase 3
37 Serotonin Antagonists Phase 3
38 Cola Nutraceutical Phase 3,Phase 1
39
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
40
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
41
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
42
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
43
Lenograstim Approved Phase 2,Phase 1 135968-09-1
44
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
45
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
46
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
47
Dactinomycin Approved Phase 2 50-76-0 2019 457193
48
Epirubicin Approved Phase 2 56420-45-2 41867
49
Etoposide Approved Phase 2 33419-42-0 36462
50
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978

Interventional clinical trials:

(show top 50) (show all 80)
id Name Status NCT ID Phase
1 Stereotactic Body Radiotherapy for Head and Neck Tumors Active, not recruiting NCT01344356 Phase 4
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
3 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
5 Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base Recruiting NCT01182753 Phase 3
6 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
7 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
8 Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors Not yet recruiting NCT02838602 Phase 3
9 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
10 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3
11 Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine Unknown status NCT00592748 Phase 1, Phase 2
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2
13 A Safety and Efficacy Study of Patients With Metastatic or Locally Advanced (Unresectable) Chondrosarcoma Completed NCT01310816 Phase 2
14 S0344 Intralesional Resection in Treating Patients With Chondrosarcoma of the Bone Completed NCT00096213 Phase 2
15 S0423 Pemetrexed Disodium in Treating Patients With Recurrent and Unresectable or Metastatic Chondrosarcoma Completed NCT00107419 Phase 2
16 Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma Completed NCT00073983 Phase 2
17 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2
18 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2
19 Linsitinib in Treating Patients With Gastrointestinal Stromal Tumors Completed NCT01560260 Phase 2
20 Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymp Completed NCT02273739 Phase 1, Phase 2
21 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
22 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2
23 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2
24 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
25 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
26 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2
27 Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma Completed NCT00003308 Phase 2
28 High-dose ICE With Amifostine Completed NCT00003657 Phase 2
29 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2
30 A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 Completed NCT00948961 Phase 1, Phase 2
31 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
32 Alanosine in Treating Patients With Cancer Completed NCT00062283 Phase 2
33 Proton Radiation for Chordomas and Chondrosarcomas Recruiting NCT01449149 Phase 1, Phase 2
34 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Recruiting NCT02066285 Phase 2
35 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2
36 Metformin And Chloroquine in IDH1/2-mutated Solid Tumors Recruiting NCT02496741 Phase 1, Phase 2
37 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2
38 Trial of Nilotinib and Adriamycin as Treatment in Liposarcomas and Leiomyosarcomas of Retroperitoneum Recruiting NCT02587169 Phase 1, Phase 2
39 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
40 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2
41 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2
42 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
43 Autologous Dendritic Cell Vaccine Loaded With Allogeneic Tumor Lysate Expression of Cancer Testis Antigens in Patients With Soft Tissue Sarcoma Recruiting NCT01883518 Phase 1, Phase 2
44 Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma Active, not recruiting NCT01330966 Phase 2
45 Proton Beam Therapy for Chondrosarcoma Active, not recruiting NCT00496522 Phase 2
46 Imatinib in Patients With Desmoid Tumor and Chondrosarcoma Active, not recruiting NCT00928525 Phase 2
47 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2
48 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2
49 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
50 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Active, not recruiting NCT00589121 Phase 2

Search NIH Clinical Center for Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma

Genetic Tests for Chondrosarcoma

Genetic tests related to Chondrosarcoma:

id Genetic test Affiliating Genes
1 Chondrosarcoma 29

Anatomical Context for Chondrosarcoma

MalaCards organs/tissues related to Chondrosarcoma:

39
Bone, Lung, Breast, Endothelial, Kidney, Thyroid, Pancreas

Publications for Chondrosarcoma

Articles related to Chondrosarcoma:

(show top 50) (show all 1485)
id Title Authors Year
1
WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis. ( 28465477 )
2017
2
Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast. ( 28402910 )
2017
3
Conservative surgery for laryngeal chondrosarcoma: a review of the most recently proposed approaches. ( 28059901 )
2017
4
Chondrosarcoma-like metastasis from a poorly differentiated uterine cervical squamous cell carcinoma. A unique morphology and diagnostic pitfall in cytology. ( 28411397 )
2017
5
Bortezomib induces apoptosis and suppresses cell growth and metastasis by inactivation of Stat3 signaling in chondrosarcoma. ( 28000897 )
2017
6
Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. ( 27696380 )
2017
7
Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma. ( 28439237 )
2017
8
Juxtacortical Mandibular Chondrosarcoma during pregnancy: A case report. ( 28512553 )
2017
9
Celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway. ( 28522217 )
2017
10
Chondrosarcoma of the Osseous Spine: An Analysis of Epidemiology, Patient Outcomes, and Prognostic Factors Using the SEER Registry From 1973 to 2012. ( 28441682 )
2017
11
Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma. ( 28432450 )
2017
12
Dedifferentiated chondrosarcoma: A survival analysis of 159 cases from the SEER database (2001-2011). ( 28420036 )
2017
13
The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling. ( 28059436 )
2017
14
Correction: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. ( 28445994 )
2017
15
Conventional chondrosarcoma in the right hand with the invasion of the pisiform and the hamate bones - case report. ( 28523331 )
2017
16
Primary chondrosarcoma of the trachea with extensive extralumenal growth. ( 28444377 )
2017
17
Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF-1/SOX9 Axis. ( 28485543 )
2017
18
Phalangeal chondrosarcoma: A rare presentation with an unusual biological behavior. ( 28465204 )
2017
19
Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma. ( 28484252 )
2017
20
Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCI' pathway. ( 27826039 )
2017
21
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
22
The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). ( 28420520 )
2017
23
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
24
Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells. ( 28085008 )
2017
25
Icariin inhibits MMPa891, MMPa893 and MMPa8913 expression through MAPK pathways in ILa891I^a89stimulated SW1353 chondrosarcoma cells. ( 28447732 )
2017
26
Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma. ( 28035378 )
2017
27
MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/I^-Catenin Signaling Pathway. ( 28535514 )
2017
28
Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells. ( 28057484 )
2017
29
Extensive Chondrosarcoma of the Nasal Septum: Endoscopic Resection and Long-Term Follow-Up. ( 27192653 )
2016
30
TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma. ( 27522523 )
2016
31
CORR Insights(Ar): Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2016
32
Proteoglycans as target for an innovative therapeutic approach in chondrosarcoma: preclinical proof of concept. ( 27573424 )
2016
33
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
34
miRNA-497 Negatively Regulates the Growth and Motility of Chondrosarcoma Cells by Targeting Cdc25A. ( 27053344 )
2016
35
Molecular oncogenesis of chondrosarcoma: impact for targeted treatment. ( 27166664 )
2016
36
Secondary Chondrosarcoma of the Upper Thoracic Costovertebral Junction with Neural Foraminal Extension and Compressing The Spinal Cord. ( 27155384 )
2016
37
False-positive (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in a patient with metallic implants following chondrosarcoma resection. ( 27123290 )
2016
38
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
39
Oncological outcome after lung metastasis in patients presenting with localized chondrosarcoma at extremities: Tokai Musculoskeletal Oncology Consortium study. ( 27536136 )
2016
40
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
41
BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway. ( 27618007 )
2016
42
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. ( 27094859 )
2016
43
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
44
CCL5 promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells. ( 27166194 )
2016
45
Retracted: Intramedullary Chondrosarcoma of Proximal Humerus. ( 27110423 )
2016
46
Rapamycin causes growth arrest and inhibition of invasion in human chondrosarcoma cells. ( 27061554 )
2016
47
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
48
The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2. ( 26596830 )
2016
49
Chondrosarcoma in the mental foramen region of the mandible: A case report. ( 27602143 )
2016
50
Temporomandibular joint chondrosarcoma: a case report and literature review. ( 27847738 )
2016

Variations for Chondrosarcoma

UniProtKB/Swiss-Prot genetic disease variations for Chondrosarcoma:

66
id Symbol AA change Variation ID SNP ID
1 EXT1 p.Asn316Ser VAR_012820

ClinVar genetic disease variations for Chondrosarcoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 EXT1 NM_000127.2(EXT1): c.528_535delCAAAGTGC (p.Lys177Glufs) deletion Pathogenic rs587776540 GRCh37 Chromosome 8, 119122751: 119122758

Copy number variations for Chondrosarcoma from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 110025 17 31160600 31198351 Translate TAF15 Chondrosarcoma

Expression for Chondrosarcoma

Search GEO for disease gene expression data for Chondrosarcoma.

Pathways for Chondrosarcoma

Pathways related to Chondrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 ADAMTS4 FGF2 MMP1 MMP13 SPARC
2 11.42 FGF2 SOX9 SPARC
3 10.92 MMP1 MMP13 SPARC
4 10.83 ADAMTS4 FGF2 MMP13 PTHLH SOX9

GO Terms for Chondrosarcoma

Cellular components related to Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.02 ADAMTS4 CNMD MMP1 MMP13 SPARC

Biological processes related to Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.54 ADAMTS4 MMP1 MMP13
2 cartilage development GO:0051216 9.5 CNMD MMP13 SOX9
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.43 EXT1 EXT2
4 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTHLH SOX9
5 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.26 EXT1 EXT2
6 ossification GO:0001503 9.26 EXT1 EXT2 SOX9 SPARC
7 cellular polysaccharide biosynthetic process GO:0033692 9.16 EXT1 EXT2
8 skeletal system development GO:0001501 9.02 ADAMTS4 CNMD EXT1 PTHLH SOX9

Molecular functions related to Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 9.43 ADAMTS4 MMP1 MMP13
2 acetylglucosaminyltransferase activity GO:0008375 9.32 EXT1 EXT2
3 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.16 EXT1 EXT2
4 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.96 EXT1 EXT2
5 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 8.62 EXT1 EXT2

Sources for Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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