MCID: CHN012
MIFTS: 63

Chondrosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Chondrosarcoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A connective tissue cancer that has physical basis in cells derived from transformed cells that produce cartilage.

MalaCards: Chondrosarcoma, also known as primary chondrosarcoma of the bone, is related to mesenchymal chondrosarcoma and extraskeletal myxoid chondrosarcoma. An important gene associated with Chondrosarcoma is EXT1 (exostosin glycosyltransferase 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related mouse phenotype behavior/neurological.

Wikipedia:63 Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.... more...

Description from OMIM:46 215300

Aliases & Classifications for Chondrosarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
chondrosarcoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

chondrosarcoma 8 9 42 22 46 10 44 48 60
primary chondrosarcoma of the bone 8
primary chondrosarcoma of bone 8
chondrosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3371
MeSH34 D002813
NCIt39 C2946
OMIM46 215300
SNOMED-CT via Orphanet57 447792005, 443520009
MESH via Orphanet35 D002813
UMLS via Orphanet61 C0008479

Related Diseases for Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Chondrosarcoma family:

Localized Chondrosarcoma

Diseases related to Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1mesenchymal chondrosarcoma31.6VIM, DES, MUC1
2extraskeletal myxoid chondrosarcoma31.4TAF15, NR4A3, TFG
3osteosarcoma30.8EXT1, CD36
4chordoma30.7MUC1, DES, S100A1, S100B, VIM
5sarcoma30.7VIM, EXT1, S100B, S100A1, SMARCB1, FUS
6giant cell tumor30.2VIM, S100B, DES, MUC1
7fibrosarcoma30.2CD36, DES, VIM
8rhabdomyosarcoma30.1VIM, S100B, S100A1, EWSR1, DES, ENO2
9synovial sarcoma30.0MUC1, DES, S100B, VIM
10osteoarthritis29.9CD36, S100A1
11leiomyosarcoma29.7VIM, S100B, S100A1, DES, MUC1, ENO2
12hemangiopericytoma29.7VIM, S100B, S100A1, DES, MUC1
13meningioma29.7VIM, S100B, S100A1, MUC1, SMARCB1
14liposarcoma29.7VIM, EWSR1, DES, FUS
15alveolar soft part sarcoma29.7VIM, DES, ENO2
16clear cell sarcoma29.7FUS, EWSR1, S100B
17lipoma29.7S100A1, DES, FUS
18adenoma29.7S100A1, MUC1, ENO2
19angiosarcoma29.7MUC1, VIM
20myxoid liposarcoma29.7EWSR1, FUS
21myxoid chondrosarcoma11.0
22clear cell chondrosarcoma10.7
23intracranial chondrosarcoma10.7
24extraskeletal mesenchymal chondrosarcoma10.7
25periosteal chondrosarcoma10.5
26periostitis10.5
27juxtacortical chondrosarcoma10.5
28localized chondrosarcoma10.4
29chondroma10.4
30cervicitis10.4
31extraosseous chondrosarcoma10.3
32laryngitis10.3
33hereditary multiple exostoses10.3
34pediatric mesenchymal chondrosarcoma10.3
35exostosis10.3
36meningitis10.3
37chondroblastoma10.2
38adult mesenchymal chondrosarcoma10.2
39ollier disease10.2
40bone osteosarcoma10.2
41chondroid chordoma10.2
42chondroblastic osteosarcoma10.1
43pediatric myxoid chondrosarcoma10.1
44adult myxoid chondrosarcoma10.1
45thyroiditis10.1
46localized osteosarcoma10.1
47adult extraosseous chondrosarcoma10.1
48paget's disease of bone10.1
49melanoma10.0VIM, S100B, S100A1, EWSR1, DES, CD36
50malignant mixed mullerian tumor10.0VIM, S100B, S100A1, DES, MUC1, ENO2

Graphical network of the top 20 diseases related to Chondrosarcoma:



Diseases related to chondrosarcoma

Clinical Features for Chondrosarcoma

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46OMIM
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Clinical features from OMIM:

215300

Clinical synopsis from OMIM:

215300

Drugs & Therapeutics for Chondrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Chondrosarcoma

Search NIH Clinical Center for Chondrosarcoma

Search CenterWatch for Chondrosarcoma

Genetic Tests for Chondrosarcoma

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22GTR
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Genetic tests related to Chondrosarcoma:

id Genetic test Affiliating Genes
1 Chondrosarcoma22

Anatomical Context for Chondrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Chondrosarcoma:

32
Bone, Lung, Breast, Endothelial, Kidney, Thyroid, Heart, Pancreas, Liver, Cerebellum, Brain, Spinal cord, Bone marrow, Colon, Trachea, Tongue, Lymph node, T cells, Testis, Uterus, Ovary, Skin, Spleen, Pineal

Animal Models for Chondrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.3FUS, EXT1, S100B, S100A1, DES, NR4A3

Publications for Chondrosarcoma

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50PubMed
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Articles related to Chondrosarcoma:

(show top 50)    (show all 1225)
idTitleAuthorsYear
1
Does Ifosfamide Therapy Improve Survival of Patients With Dedifferentiated Chondrosarcoma? (24197392)
2013
2
Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. (23584483)
2013
3
Paediatric chondrosarcoma of the sinonasal region. (23575105)
2013
4
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. (23588370)
2013
5
Dedifferentiated chondrosarcoma of the cervical spine: a case report. (23375124)
2013
6
NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine. (22384167)
2012
7
Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003. (22363068)
2012
8
Myxoid chondrosarcoma of the cricoid cartilage. (23032857)
2012
9
Can we save the arm? A 38-year-old man with morbus ollier (enchondromatosis) and secondary chondrosarcoma. (22544147)
2012
10
Primary chondrosarcoma of male breast: a rare case. (24082599)
2012
11
Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis. (22809428)
2012
12
IL-8 increases integrin expression and cell motility in human chondrosarcoma cells. (21590707)
2011
13
Huge tumor thrombus of chondrosarcoma on FDG PET/CT. (21892027)
2011
14
Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway. (21328612)
2011
15
Therapeutic molecular targets in human chondrosarcoma. (21078112)
2010
16
Cellular variant of extraskeletal myxoid chondrosarcoma with Ewing's sarcoma-like areas: a diagnostic pitfall in core needle biopsy. (20496272)
2010
17
BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress. (20067774)
2010
18
Allograft sternochondral replacement after resection of large sternal chondrosarcoma. (19660292)
2010
19
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. (20123451)
2010
20
Case report: Mesenchymal chondrosarcoma of the lumbar spine in a child. (20300902)
2010
21
Secondary chondrosarcoma in an enchondroma in a proximal phalanx of toe. A diagnostic problem. A case report. (20307452)
2009
22
Primary dedifferentiated chondrosarcoma of the lung. (19593290)
2009
23
High-grade chondrosarcoma mimicking Brodie's abscess. (19664486)
2009
24
Mandibular periosteal (juxtacortical) chondrosarcoma. (20126915)
2009
25
Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. (18584350)
2008
26
Primary spinal intradural mesenchymal chondrosarcoma. A pediatric case report. (18243318)
2008
27
High-dose radiotherapy in the management of chordoma and chondrosarcoma of the skull base and cervical spine: Part 1--Clinical outcomes. (17524633)
2007
28
siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line. (15499569)
2005
29
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
30
Skull metastasis from clear cell chondrosarcoma. (16041184)
2005
31
Absence of a correlation between the presence of a single nucleotide polymorphism in the matrix metalloproteinase 1 promoter and outcome in patients of chondrosarcoma. (15534109)
2004
32
Cardiac chondrosarcoma producing parathyroid hormone-related protein. (15226640)
2004
33
Malignant transformation of a benign enchondroma of the hand to secondary chondrosarcoma with isolated pulmonary metastasis. (15285552)
2004
34
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (12543801)
2003
35
Pathologic quiz case: chest wall mass in a 74-year-old man. Extraskeletal myxoid chondrosarcoma. (14521439)
2003
36
Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (12378528)
2002
37
Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas. (12183075)
2002
38
Human chondrosarcoma secretes vascular endothelial growth factor to induce tumor angiogenesis and stores basic fibroblast growth factor for regulation of its own growth. (11774282)
2002
39
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. (10626952)
2000
40
Phenotypic plasticity and prognostic factors in extraskeletal myxoid chondrosarcoma. (10721413)
2000
41
Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease. (9723029)
1998
42
Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. (9060841)
1997
43
Mesenchymal chondrosarcoma of the cauda equina. (7671456)
1995
44
Mesenchymal chondrosarcoma. An immunohistochemical study. (2202275)
1990
45
Intracranial chondrosarcoma--case report. (1696697)
1990
46
Ultrastructural study of a clear cell chondrosarcoma. (3739043)
1986
47
Mesenchymal chondrosarcoma of the kidney. (6498739)
1984
48
Extraskeletal mesenchymal chondrosarcoma of the orbit. (7174941)
1982
49
"Mesenchymal" chondrosarcoma, a rare malignant chondroid tumor usually primary in bone. Report of a case arising in extraskeletal soft tissue. (4292221)
1967
50
JUXTACORTICAL CHONDROSARCOMA. (14275172)
1965

Genetic Variations for Chondrosarcoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Chondrosarcoma:

62
id Symbol AA change Variation ID SNP ID
1EXT1p.Asn316SerVAR_012820

Expression for genes affiliated with Chondrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondrosarcoma

Search GEO for disease gene expression data for Chondrosarcoma.

Pathways for genes affiliated with Chondrosarcoma

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29KEGG
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Pathways related to Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FUS, TAF15, NR4A3, EWSR1

Compounds for genes affiliated with Chondrosarcoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Chondrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.6VIM, S100B, S100A1, EWSR1, DES, MUC1
2tyrosine4411.6S100B, S100A1, EWSR1, TFG, DES, NR4A3
3paraffin4411.6VIM, S100B, S100A1, EWSR1, DES, MUC1
4progesterone44 59 28 11 2415.5VIM, S100B, S100A1, DES, MUC1, ENO2
5hematoxylin4411.4VIM, S100B, S100A1, DES, MUC1, ENO2
6heparin44 28 11 2414.4VIM, EXT1, S100B, DES, CD36, ENO2
7dexamethasone44 49 28 1114.3VIM, S100B, MUC1, CD36, ENO2, ESRRB
8s 1004411.3ENO2, MUC1, DES, S100B, VIM
9mucicarmine4411.3VIM, S100B, S100A1, DES, MUC1
10b 7234411.3VIM, S100B, S100A1, DES, MUC1
11vegf4411.3VIM, S100B, DES, MUC1, CD36, ENO2
12hyaluronic acid44 2412.3VIM, DES, MUC1, CD36, ENO2
13formaldehyde44 2412.3VIM, S100B, DES, MUC1, ENO2
14glutamine4411.2VIM, S100B, EWSR1, CD36, ENO2
15reticulin4411.2VIM, S100B, DES, MUC1
16iron44 2412.2VIM, S100B, S100A1, DES, ENO2
17toluidine4411.2VIM, S100A1, DES, ENO2
18biotin44 11 2413.2VIM, S100A1, DES, MUC1
19adriamycin4411.2VIM, DES, MUC1, CD36
20bromodeoxyuridine4411.2VIM, S100B, DES, ENO2
21cyclic amp44 2412.2VIM, S100B, EWSR1, DES, MUC1
22dmso4411.1ENO2, CD36, MUC1, VIM
23orcein4411.1VIM, S100B, DES
24eosin4411.1MUC1, S100B, VIM
25acth4411.1S100B, MUC1, ENO2, ESRRB
26cysteine4411.1VIM, S100B, S100A1, DES, MUC1, CD36
27hydroxyapatite4411.0VIM, S100B, CD36
28acetylcholine44 49 28 11 2415.0ENO2, S100A1
294-hydroxytamoxifen4411.0ESRRB, S100B, VIM
30askin4411.0ENO2, EWSR1
31ganglioside4411.0VIM, DES, ENO2
32procollagen4411.0CD36, DES, VIM
33creatinine4411.0CD36
34edss4411.0ENO2, S100B
35dbc-amp4411.0VIM, S100B, ENO2
36nor 14410.9NR4A3, EWSR1
37silver4410.9ENO2, DES, S100A1
38progestin4410.9VIM, DES, MUC1
39testosterone44 59 11 2413.9VIM, S100B, DES, MUC1, ENO2
40olopatadine44 1111.8S100A1, S100B
41cytarabine44 49 1112.7CD36, MUC1, VIM
422-methoxyethanol4410.7S100A1, VIM
43catecholamine4410.6ENO2, S100B, VIM
44tartrate4410.3VIM, CD36

GO Terms for genes affiliated with Chondrosarcoma

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16Gene Ontology
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Molecular functions related to Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.8FUS, VIM, S100B, S100A1, EWSR1, TFG
2S100 protein bindingGO:04454810.6S100A1, S100B

Products for genes affiliated with Chondrosarcoma

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Sources for Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet