MCID: CHN012
MIFTS: 50

Chondrosarcoma malady

Bone, Cancer categories

Summaries for Chondrosarcoma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A connective tissue cancer that has physical basis in cells derived from transformed cells that produce cartilage.

MalaCards: Chondrosarcoma, also known as primary chondrosarcoma of the bone, is related to extraskeletal myxoid chondrosarcoma and synovial sarcoma. An important gene associated with Chondrosarcoma is EXT1 (exostosin glycosyltransferase 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Related mouse phenotype behavior/neurological.

Wikipedia:64 Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.... more...

Description from OMIM:47 215300

Aliases & Classifications for Chondrosarcoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
chondrosarcoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

chondrosarcoma 8 9 43 22 47 10 45 49 61
primary chondrosarcoma of the bone 8
primary chondrosarcoma of bone 8
chondrosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3371
MeSH35 D002813
NCIt40 C2946
OMIM47 215300
MESH via Orphanet36 D002813
SNOMED-CT via Orphanet58 443520009
UMLS via Orphanet62 C0008479

Related Diseases for Chondrosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chondrosarcoma family:

localized chondrosarcoma

Diseases related to Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1extraskeletal myxoid chondrosarcoma31.4TAF15, NR4A3, TFG
2synovial sarcoma30.0MUC1, DES, S100B, VIM
3osteoarthritis30.0CD36, S100A1
4rhabdoid tumor29.8VIM, DES, MUC1, SMARCB1
5ependymoma29.8VIM, S100B, MUC1, ENO2
6alveolar soft part sarcoma29.8VIM, DES, ENO2
7clear cell sarcoma29.8FUS, EWSR1, S100B
8adenoma29.8S100A1, MUC1, ENO2
9angiosarcoma29.8MUC1, VIM
10teratoma29.8SMARCB1, ENO2
11myxoid liposarcoma29.8EWSR1, FUS
12clear cell chondrosarcoma10.8
13intracranial chondrosarcoma10.7
14extraskeletal mesenchymal chondrosarcoma10.7
15enchondroma10.7
16periosteal chondrosarcoma10.6
17juxtacortical chondrosarcoma10.5
18osteochondroma10.5
19synovial chondromatosis10.5
20hereditary multiple exostoses10.3
21ollier disease10.3
22pediatric mesenchymal chondrosarcoma10.3
23chondroblastoma10.3
24adult mesenchymal chondrosarcoma10.3
25bone osteosarcoma10.2
26chondroblastic osteosarcoma10.2
27pediatric myxoid chondrosarcoma10.2
28adult myxoid chondrosarcoma10.2
29hypoxia10.2
30adult extraosseous chondrosarcoma10.1
31localized chondrosarcoma10.1
32malignant mesenchymal tumor10.1
33bone carcinoma10.0
34mccune albright syndrome10.0
35ossifying fibroma10.0
36osteomalacia10.0
37myositis ossificans10.0
38fibrous dysplasia10.0
39small cell sarcoma10.0
40horner's syndrome10.0
41squamous cell carcinoma10.0
42mccune–albright syndrome10.0
43sarcoma10.0VIM, EXT1, S100B, S100A1, SMARCB1, FUS
44leiomyosarcoma10.0VIM, S100B, S100A1, DES, MUC1, ENO2
45melanoma10.0VIM, S100B, S100A1, EWSR1, DES, CD36
46rhabdomyosarcoma10.0VIM, S100B, S100A1, EWSR1, DES, ENO2
47malignant mixed mullerian tumor10.0VIM, S100B, S100A1, DES, MUC1, ENO2
48dermatofibrosarcoma protuberans10.0VIM, S100B, S100A1, DES, MUC1
49chordoma10.0MUC1, DES, S100A1, S100B, VIM
50malignant fibroxanthoma10.0VIM, S100B, S100A1, DES, MUC1

Graphical network of the top 20 diseases related to Chondrosarcoma:



Diseases related to chondrosarcoma

Clinical Features for Chondrosarcoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

215300

Clinical synopsis from OMIM:

215300

Drugs & Therapeutics for Chondrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Chondrosarcoma

Search NIH Clinical Center for Chondrosarcoma

Search CenterWatch for Chondrosarcoma

Genetic Tests for Chondrosarcoma

Sources:
22GTR
See all sources

Genetic tests related to Chondrosarcoma:

id Genetic test Affiliating Genes
1 Chondrosarcoma22

Anatomical Context for Chondrosarcoma

Animal Models for Chondrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Chondrosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.3FUS, EXT1, S100B, S100A1, DES, NR4A3

Publications for Chondrosarcoma

Sources:
51PubMed
See all sources

Articles related to Chondrosarcoma:

(show top 50)    (show all 1233)
idTitleAuthorsYear
1
Chondrosarcoma of the maxilla: A case report and review of literature. (24250092)
2013
2
Cytogenetic analysis of a low-grade secondary peripheral chondrosarcoma arising in synovial chondromatosis. (23239852)
2013
3
Paediatric chondrosarcoma of the sinonasal region. (23575105)
2013
4
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. (23588370)
2013
5
The imaging of cartilaginous bone tumours. II. Chondrosarcoma. (23053201)
2013
6
Multiplanar osteotomies guided by navigation in chondrosarcoma of the knee. (23464952)
2013
7
Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFI^ as potential targets. (23415961)
2013
8
Total scapulectomy for the treatment of chondrosarcoma in a cat. (22812474)
2012
9
Chondrosarcoma of the proximal phalanx of the fourth digit: a rare location. (23185160)
2012
10
Chondrosarcoma of the spinous process: a rare presentation. (23275812)
2012
11
Intraluminal chondrosarcoma leading to occlusion of the brachiocephalic trunk. (21480142)
2011
12
IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells. (21278254)
2011
13
Primary spinal dumbbell-shaped mesenchymal chondrosarcoma located intradurally and extradurally. (22259697)
2011
14
Huge tumor thrombus of chondrosarcoma on FDG PET/CT. (21892027)
2011
15
Residual postoperative tumour volume predicts outcome after high-dose radiotherapy for chordoma and chondrosarcoma of the skull base and spine. (20980136)
2011
16
Chondrosarcoma of sinonasal cavity: a case report and brief literature review. (20415174)
2010
17
Endoscopic resection of low grade, subglottic chondrosarcoma. (19566974)
2009
18
High-grade chondrosarcoma mimicking Brodie's abscess. (19664486)
2009
19
Mandibular periosteal (juxtacortical) chondrosarcoma. (20126915)
2009
20
Intracranial chondrosarcoma: a case report and review of the literature. (20077365)
2009
21
Chondrosarcoma of the jaws. (20166380)
2009
22
Extraskeletal myxoid chondrosarcoma arising from the clavicle. (16786132)
2006
23
The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF. (16324193)
2005
24
Clear cell chondrosarcoma in association with niemann-pick disease. (18521415)
2005
25
Extraskeletal myxoid chondrosarcoma: a report of a gynecologic case. (15992919)
2005
26
Cardiac chondrosarcoma producing parathyroid hormone-related protein. (15226640)
2004
27
Radiation therapy for chordoma and chondrosarcoma of the skull base and the cervical spine. Prognostic factors and patterns of failure. (12707713)
2003
28
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (12543801)
2003
29
Mesenchymal chondrosarcoma originating from the femoral vein. (12514602)
2003
30
The expression of selected immunocytochemical diagnostic markers in the case of chondrosarcoma with a mesenchymal component. (14655155)
2003
31
Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. (11953889)
2002
32
Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (12378528)
2002
33
Mesenchymal chondrosarcoma of soft tissues of the calf. (11334455)
2001
34
Intracranial low-grade chondrosarcoma with hyperostosis of the skull: a case report. (11212904)
2000
35
Chondrosarcomatous differentiation in metastatic deposit of serous papillary cystadenocarcinoma. (10886727)
2000
36
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. (10472345)
1999
37
Mesenchymal chondrosarcoma of the hyoid bone: a case report. (9886185)
1998
38
Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas. (9065576)
1997
39
Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression in cartilage and chondrosarcoma. (9097023)
1997
40
Primary pulmonary chondrosarcoma mimicking bronchogenic cyst on CT and MRI. (8877170)
1996
41
Extraskeletal myxoid chondrosarcoma with dedifferentiation. (8847071)
1995
42
Mesenchymal chondrosarcoma of the maxilla. Report of a case. (2019783)
1991
43
Extraosseus uptake with bone scintigraphy. Renal mesenchymal chondrosarcoma with metastasis. (2054997)
1991
44
Case report 484: Mesenchymal chondrosarcoma of the left fifth rib. (3212495)
1988
45
Aspiration biopsy cytology of metastatic extraskeletal myxoid chondrosarcoma and its cytologic differential diagnosis. (3861047)
1985
46
Retroperitoneal mesenchymal chondrosarcoma. (4056423)
1985
47
Mesenchymal chondrosarcoma - a case report with brief review of the literature. (7187459)
1982
48
Mandibular metastasis of an extraskeletal myxoid chondrosarcoma arising on the plantar surface of the foot: report of case. (273676)
1978
49
Mesenchymal chondrosarcoma. A case report. (845214)
1977
50
Case reports; chondrosarcomatous degeneration of a myositis ossificans. (15425073)
1950

Genetic Variations for Chondrosarcoma

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Chondrosarcoma:

63
id Symbol AA change Variation SNP ID
1EXT1p.Asn316SerVAR_012820

Expression for genes affiliated with Chondrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chondrosarcoma

Search GEO for disease gene expression data for Chondrosarcoma.

Pathways for genes affiliated with Chondrosarcoma

Sources:
30KEGG
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Pathways related to Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FUS, TAF15, NR4A3, EWSR1

Compounds for genes affiliated with Chondrosarcoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Chondrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.6EWSR1, ESRRB, MUC1, CD36, ENO2, S100B
2tyrosine4511.6S100B, MUC1, NR4A3, S100A1, EWSR1, TFG
3paraffin4511.6ENO2, EWSR1, DES, S100A1, S100B, VIM
4progesterone45 60 29 11 2415.5DES, S100B, ESRRB, ENO2, MUC1, S100A1
5hematoxylin4511.4VIM, ENO2, MUC1, DES, S100A1, S100B
6heparin45 29 11 2414.4ENO2, DES, S100B, EXT1, VIM, CD36
7dexamethasone45 50 29 1114.3ESRRB, MUC1, S100B, ENO2, CD36, VIM
8s 1004511.3VIM, ENO2, MUC1, DES, S100B
9mucicarmine4511.3VIM, MUC1, DES, S100B, S100A1
10b 7234511.3VIM, MUC1, DES, S100A1, S100B
11vegf4511.3VIM, ENO2, CD36, MUC1, DES, S100B
12hyaluronic acid45 2412.3DES, VIM, ENO2, MUC1, CD36
13formaldehyde45 2412.3MUC1, DES, ENO2, S100B, VIM
14glutamine4511.2VIM, S100B, ENO2, CD36, EWSR1
15reticulin4511.2MUC1, VIM, S100B, DES
16iron45 2412.2S100B, DES, VIM, ENO2, S100A1
17toluidine4511.2S100A1, VIM, DES, ENO2
18biotin45 11 2413.2DES, MUC1, S100A1, VIM
19adriamycin4511.2MUC1, CD36, DES, VIM
20bromodeoxyuridine4511.2DES, VIM, ENO2, S100B
21cyclic amp45 2412.2DES, EWSR1, VIM, MUC1, S100B
22dmso4511.1ENO2, CD36, MUC1, VIM
23orcein4511.1DES, S100B, VIM
24eosin4511.1VIM, MUC1, S100B
25acth4511.1ESRRB, S100B, MUC1, ENO2
26cysteine4511.1CD36, S100A1, MUC1, DES, S100B, VIM
27hydroxyapatite4511.0VIM, S100B, CD36
28acetylcholine45 50 29 11 2415.0ENO2, S100A1
294-hydroxytamoxifen4511.0VIM, ESRRB, S100B
30askin4511.0ENO2, EWSR1
31ganglioside4511.0VIM, DES, ENO2
32procollagen4511.0DES, CD36, VIM
33creatinine4511.0CD36
34nor 14511.0EWSR1, NR4A3
35dbc-amp4511.0VIM, S100B, ENO2
36edss4510.9S100B, ENO2
37silver4510.9DES, S100A1, ENO2
38progestin4510.9MUC1, DES, VIM
39testosterone45 60 11 2413.9VIM, S100B, MUC1, ENO2, DES
40olopatadine45 1111.8S100B, S100A1
41cytarabine45 50 1112.7MUC1, CD36, VIM
422-methoxyethanol4510.7VIM, S100A1
43catecholamine4510.6ENO2, S100B, VIM
44tartrate4510.3VIM, CD36

GO Terms for genes affiliated with Chondrosarcoma

Sources:
16Gene Ontology
See all sources

Molecular functions related to Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.8FUS, VIM, S100B, S100A1, EWSR1, TFG
2S100 protein bindingGO:04454810.6S100A1, S100B

Products for genes affiliated with Chondrosarcoma

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Sources for Chondrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet