Chondrosarcoma malady

Wikipedia: Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage....⁴⁴ more...

MalaCards: Chondrosarcoma, also known as chondrosarcoma nos (morphologic abnormality), is related to myxoid chondrosarcoma and extraskeletal myxoid chondrosarcoma. An important gene associated with Chondrosarcoma is NR4A3 (nuclear receptor subfamily 4, group A, member 3), and among its related pathways are Breast Cancer Regulation by Stathmin1 and PTEN Pathway. The compounds lysine and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and testis, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

OMIM: 215300

Aliases & Descriptions:

chondrosarcoma 6 7 30 8 33 32 43 chondrosarcoma nos (morphologic abnormality) 6 chondrosarcoma (morphologic abnormality) 6 primary chondrosarcoma of the bone 6

primary chondrosarcoma of bone 6 conventional chondrosarcoma 43 chondrosarcoma of bone 6

Diseases related to chondrosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 904)

id	Related Disease	Score	Top Affiliating Genes
1	myxoid chondrosarcoma	38.3	VIM, CHI3L1, MUC1, MTAP, S100A1, S100B
2	extraskeletal myxoid chondrosarcoma	37.6	VIM, CHI3L1, MUC1, S100A1, S100B, FUS
3	mesenchymal chondrosarcoma	34.0	VIM, MUC1, SPARC, DES
4	clear cell chondrosarcoma	33.9	RB1, VIM, CD36, ALPP, PTHLH, SPARC
5	osteochondroma	32.5	BMP2, FGF2, FGF9, FGFR1, FGFR3, EXT1
6	enchondroma	31.9	MMP13, MCM6, IDH1, IDH2, ESR2, PTH1R
7	chondroid chordoma	31.3	VIM, MUC1, S100A1, S100B, CEACAM3
8	ollier disease	30.4	CD36, MMP2, IDH1, IDH2, EXT1, EXT2
9	chordoma	29.6	SERPINA3, VIM, VEGFA, VCAM1, LGALS1, MUC1
10	parachordoma	29.3	VIM, MUC1, S100B, T, CEACAM3, DES
11	chondroma	29.1	SERPINA3, S100A1, CDK4, MDM2, IDH1, IDH2
12	bone cancer	28.8	CD36, IL1B, ENO2, F2R, ALPP, EWSR1
13	squamous cell carcinoma	28.2	LGALS1, CD44, MMP19, MMP7, MKI67, PTHLH
14	chondroblastoma	28.0	SERPINA3, VIM, S100A1, IL8, TNFSF11, PTGS2
15	exostosis	27.8	BMP2, BGLAP, MMP13, EXT1, EXT2, TGFB1
16	angiosarcoma	27.4	PIK3CG, SERPINA3, VIM, VEGFA, MYOG, MYOD1
17	periostitis	27.2	VEGFA, BMP2, BGLAP, MUC1, CD36, MMP13
18	rhabdomyosarcoma	23.4	RB1, VIM, VEGFA, VCL, MYOG, MYOD1
19	osteosarcoma	20.9	PIK3CB, PIK3CG, RB1, VIM, VEGFA, MYOG
20	soft tissue sarcoma	20.5	RB1, SERPINA3, VIM, VEGFA, MYOG, MYOD1
21	sarcoma	18.7	PIK3CB, PIK3CG, RB1, SERPINB2, SERPINA3, VIM
22	hypoxia	18.3	PIK3CB, PIK3CG, RB1, VEGFA, VCAM1, MYOD1
23	carcinoma	17.1	PIK3CB, PIK3CG, PDCD5, RB1, SERPINB2, SERPINA3
24	thyroiditis	16.9	PIK3CB, PIK3CG, PDCD5, RB1, SERPINB2, VIM
25	benign mesothelioma	14.7	VIM, MYOG, MYOD1, BCL2L1, MUC1, MTAP
26	neurilemmoma	14.7	VIM, BMP2, MUC1, S100A1, S100B, ENO2
27	malignant mixed mullerian tumor	14.6	VIM, MUC1, S100A1, S100B, CEACAM3, MMP7
28	chst3-related skeletal dysplasia	14.6	MMP13, FGFR1, FGFR2, FGFR3, PTH1R, PTHLH
29	perivascular epithelioid cell tumor	14.5	VIM, MUC1, S100A1, S100B, CDKN2A, ACTC1
30	ovarian sex cord tumors	14.5	VIM, MUC1, CEACAM3, ENO2, ALPP, PTHLH
31	polymorphous low-grade adenocarcinoma	14.5	VIM, MUC1, S100A1, S100B, CEACAM3, ACTC1
32	glomus tumor	14.5	VIM, MUC1, S100A1, S100B, CDKN2B, ACTC1
33	syringoma	14.5	VIM, MUC1, S100A1, S100B, CEACAM3, GFAP
34	rectum sarcomatoid carcinoma	14.4	VIM, BMP2, MUC1, S100A1, S100B, MKI67
35	sarcomatoid mesothelioma	14.4	VIM, MUC1, S100A1, CEACAM3, PDPN, ACTC1
36	epithelioid leiomyosarcoma	14.4	SERPINA3, VIM, ENO2, PTHLH, ACTC1, DES
37	alveolar rhabdomyosarcoma	14.4	RB1, MYOG, MYOD1, CDK4, MDM2, ENO2
38	sertoli-leydig cell tumor	14.4	VIM, MYOG, MUC1, CEACAM3, ENO2, ALPP
39	fibrous histiocytoma	14.4	SERPINA3, VIM, S100B, FUS, CTSB, ACTC1
40	pediatric cns embryonal cell carcinoma	14.4	VCL, MYOG, MYOD1, BMP2, ITGB1, FGFR1
41	spindle cell lipoma	14.4	VIM, S100A1, CDK4, MDM2, ACTC1, DES
42	malignant peripheral nerve sheath tumor	14.4	VIM, MYOG, BMP2, S100A1, S100B, CDKN2A
43	desmoplastic small round cell tumor	14.4	VIM, MYOG, MYOD1, MUC1, S100B, ENO2
44	osteochondrodysplasia	14.4	FGFR3, PTH1R, PTHLH, CTSK, COL11A2, SOX9
45	pleomorphic adenoma	14.3	VIM, BMP2, LECT1, MUC1, S100A1, S100B
46	craniosynostosis	14.3	BMP2, BMP6, FGF2, FGF9, FGFR1, FGFR2
47	cutaneous leiomyosarcoma	14.3	VIM, MUC1, S100B, ACTC1, DES
48	rhabdoid tumors	14.3	VIM, MYOD1, MUC1, IGF2, ALPP, SPP1
49	epulis	14.3	VIM, S100B, FGF2, ENO2, DES
50	achondroplasia	14.3	FGF2, FGF3, FGF9, FGFR1, FGFR2, FGFR3

Clinical features from OMIM: 215300

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to chondrosarcoma:

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MGI Mouse Phenotypes related to chondrosarcoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.1	MYOG, MYOD1, FST, ITGB3, IL10RB, PTH1R
2	endocrine/exocrine gland phenotype	MP:0005379	11.0	FUS, CDKN2B, FGFR1, FGFR2, EWSR1, ETV6
3	craniofacial phenotype	MP:0005382	11.0	T, FST, INHBA, FGF9, FGFR2, EXT1
4	embryogenesis phenotype	MP:0005380	10.9	PIK3CB, VIM, VCL, MYOG, RAF1, BECN1
5	hematopoietic system phenotype	MP:0005397	10.4	SERPINB2, BCL2, BCL2L1, CHUK, XIAP, FUS
6	renal/urinary system phenotype	MP:0005367	10.2	PARVA, BCL2, CHUK, BAX, CDKN1A, CDKN2B
7	normal phenotype	MP:0002873	10.0	VEGFA, MYOG, MYOD1, BMP2, PARVB, LGALS1
8	immune system phenotype	MP:0005387	9.7	SERPINB2, VIM, RAF1, LGALS1, LECT1, CHUK
9	other phenotype	MP:0005395	9.4	CDKN2A, ITGB1, ITGB3, MMP14, MAPT, CAPN2
10	integument phenotype	MP:0010771	9.3	PIK3CG, RB1, MYOG, RAF1, BECN1, PARP1
11	nervous system phenotype	MP:0003631	9.2	RB1, VCL, BMP2, RAF1, BECN1, PARP1
12	hearing/vestibular/ear phenotype	MP:0005377	9.2	RB1, BMP2, PARP1, BCL2, CHUK, BAX
13	no phenotypic analysis	MP:0003012	8.8	RB1, VEGFA, VCAM1, MYOD1, PARP1, MUC1
14	limbs/digits/tail phenotype	MP:0005371	8.8	RB1, VEGFA, VCL, BMP2, LEP, CHUK
15	liver/biliary system phenotype	MP:0005370	8.6	VEGFA, MTAP, CD36, MET, IL10RB, IL6
16	digestive/alimentary phenotype	MP:0005381	8.5	RB1, VEGFA, VCL, BMP2, BCL2, LEP
17	behavior/neurological phenotype	MP:0005386	8.2	RB1, VIM, MYOG, LGALS1, LEP, S100A1
18	mortality/aging	MP:0010768	8.2	PIK3CB, RB1, SERPINB2, VEGFA, VCAM1, VCL
19	growth/size phenotype	MP:0005378	7.6	PIK3CB, PIK3CG, RB1, SERPINB2, VCAM1, VCL
20	reproductive system phenotype	MP:0005389	6.5	VEGFA, MYOD1, BMP2, BECN1, LEP, CHUK
21	skeleton phenotype	MP:0005390	6.4	PIK3CG, RB1, VEGFA, MYOG, MYOD1, BMP2
22	adipose tissue phenotype	MP:0005375	6.4	RB1, MYOG, MYOD1, BCL2, LEP, CDKN1A
23	homeostasis/metabolism phenotype	MP:0005376	6.0	PIK3CB, PIK3CG, RB1, SERPINB2, VIM, VEGFA
24	vision/eye phenotype	MP:0005391	5.3	RB1, VIM, VEGFA, RAF1, BCL2, LECT1
25	muscle phenotype	MP:0005369	4.9	PIK3CG, RB1, SERPINB2, VIM, VEGFA, VCL
26	tumorigenesis	MP:0002006	4.5	PIK3CB, RB1, BECN1, BCL2, BCL2L1, LEP
27	cardiovascular system phenotype	MP:0005385	3.9	PIK3CB, PIK3CG, RB1, VIM, VEGFA, VCAM1
28	cellular phenotype	MP:0005384	3.8	PIK3CB, PIK3CG, RB1, VIM, VEGFA, VCAM1

Articles related to chondrosarcoma:

(show top 50)    (show all 222)

id	Title	Authors	Year	Affiliating Genes
1	IL-8 increases integrin expression and cell motility in human chondrosarcoma cells. (21590707)	Lee C.Y.... Tang C.H.	2011	ITGAV, IL8, ITGB3
2	The antiapoptotic gene survivin is highly expressed i n human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. (21457573)	Lechler P.... Schaumburger J.	2011	ETV6
3	Involvement of matrix metalloproteinase-3 in CCL5/CCR 5 pathway of chondrosarcomas metastasis. (19682436)	Tang C.H.... Tan T.W.	2010	MMP3, PIK3CB
4	BFPP, a phloroglucinol derivative, induces cell apopt osis in human chondrosarcoma cells through endoplasmic reticulum stress. (20067774)	Liu J.F.... Tang C.H.	2010	HSPA5, HSP90B1
5	Involvement of integrin up-regulation in RANKL/RANK p athway of chondrosarcomas migration. (20506523)	Hsu C.J.... Tang C.H.	2010	TNFSF11, TNFRSF11A
6	Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells. (18814143)	Lai T.H.... Tang C.H.	2009	ITGAV, ITGB3, CXCL12
7	Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells. (19549705)	Chiu Y.C.... Tang C.H.	2009	ADIPOR1, ADIPOR2
8	A novel mutated cell line with characteristics of ded ifferentiated chondrosarcoma. (19724881)	Yang L.... Ju G.	2009	S100A1
9	Glial cell-derived neurotrophic factor increases migr ation of human chondrosarcoma cells via ERK and NF-kappaB pathways. (19399830)	Su C.M.... Tang C.H.	2009	MAPK1, NFKB1, IKBKB
10	Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor. (19168585)	Yang S.N.... Tang C.H.	2009	LEP
11	Dedifferentiated peripheral chondrosarcomas: regulati on of EXT-downstream molecules and differentiation-related genes. (19734846)	Rozeman L.B.... Hogendoorn P.C.	2009	FGF2
12	Immunohistochemical expression of estrogen receptors in chondrosarcomas and enchondromas. (18203781)	Grifone T.J.... Brooks J.J.	2008	ESR2
13	Chondrosarcoma and peroxisome proliferator-activated receptor. (18725985)	Nishida K.... Ozaki T.	2008	PPARG
14	Alendronate inhibits cell invasion and MMP-2 secretio n in human chondrosarcoma cell line. (17640487)	Lai T.J.... Fong Y.C.	2007	MMP2
15	Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. (16400033)	Tiet T.D.... Wunder J.S.	2006	PTHLH
16	Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell. (16157221)	Jang J.H.... Chung C.P.	2005	TNC
17	Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. (15731776)	Muller S.... Aigner T.	2005	COL2A1
18	Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas. (15685701)	Rozeman L.B.... BovAce J.V.	2005	PTH1R, PTHLH
19	RNAi mediated MMP-1 silencing inhibits human chondrosarcoma invasion. (15927440)	Yuan J.... Scully S.P.	2005	MMP1
20	The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. (15744499)	Hameetman L.... Bovee J.V.	2005	EXT1
21	Genetics of chondrosarcoma and related tumors. (15187889)	Sandberg A.A.	2004	NR4A3
22	Effect of IL-1alpha on the expression of cartilage matrix proteins in human chondrosarcoma cell line OUMS-27. (15488896)	Aida Y.... Matsumura H.	2004	BMP2, MATN1
23	Cardiac chondrosarcoma producing parathyroid hormone-related protein. (15226640)	Kase S.... Ito H.	2004	PTHLH
24	Identification of a single nucleotide polymorphism in the MMP-1 promoter in chondrosarcoma. (15334640)	Dickey I.D.... Scully S.P.	2004	MMP1
25	Telomerase reverse transcriptase subunit expression is associated with chondrosarcoma malignancy. (15346061)	Martin J.A.... Buckwalter J.A.	2004	TERT
26	The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (12543801)	Laflamme C.... Labelle Y.	2003	NR1H2, NR4A3, SIX3
27	The C-terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines. (14554221)	Lee J.W.... Scully S.P.	2003	PTK2
28	Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells. (12553050)	Matsui Y.... Yoshikawa H.	2002	GFM1
29	Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. (11777908)	Suzuki M.... Terao T.	2002	PLAU, SPINT2
30	p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells. (12587980)	Ju J.W.... Chun J.S.	2002	TNF, VCAM1
31	Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas. (12183075)	Aoyama T.... Toguchida J.	2002	NFATC1, NFATC2
32	Transforming growth factor-beta isoform and receptor expression in chondrosarcoma of bone. (12021923)	Masi L.... Franchi A.	2002	TGFBR1, TGFB1, TGFB3
33	CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells. (12402308)	Kobayashi H.... Terao T.	2002	PLAU, MAPK10, PLAUR
34	Fluoroquinolone's effect on growth of human chondrocy tes and chondrosarcomas. In vitro and in vivo correlation. (11685846)	Multhaupt H.A.... Lackman R.D.	2001	VIM
35	The clinical significance of tenascin-C splice varian t expression in chondrosarcoma. (11721178)	Ghert M.A.... Scully S.P.	2001	TNC
36	IL-1beta-induced expression of matrix metalloproteinases and gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) in a chondrosarcoma cell line (OUMS-27). (11732857)	Ieda Y.... Kato T.	2001	MMP13, MMP1
37	Platelet-derived growth factor-alpha receptor expression supports the growth of conventional chondrosarcoma and is associated with adverse outcome. (11717542)	Sulzbacher I.... Chott A.	2001	PDGFRA
38	Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. (11140704)	Bovee J.V.... Hogendoorn P.C.	2000	FGFR1, FGFR3, FGF2
39	Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes. (10937620)	Matsumura T.... Trippel S.B.	2000	TGFB1, IGF1
40	Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma. (10906887)	Scully S.P.... Block J.A.	2000	MMP1
41	Expression of cell cycle-associated proteins CDK4, p27, and E2F-1 in chondrosarcoma of the jaws. (11314534)	Si X.H.	2000	CDK4, E2F1
42	Involvement of caspase-3 in epigallocatechin-3-gallat e-mediated apoptosis of human chondrosarcoma cells. (10772904)	Islam S.... Haqqi T.M.	2000	CASP3, PARP1
43	Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2). (10895826)	Harris M.... Telford N.	2000	TAF15
44	Abl expression, tumour grade, and apoptosis in chondrosarcoma. (10748867)	O'Donovan M.... Gaffney E.F.	1999	ABL1
45	De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma. (9726043)	Aigner T.... Kirchner T.	1998	CD36
46	Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor. (9665469)	Uria J.A.... Lopez-Otin C.	1998	FGF2, MMP13
47	Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas. (8712735)	Yamaguchi T.... Sasaki M.S.	1996	TP53
48	Immunohistochemical localization of bone Gla protein and osteonectin in normal human bone and cartilage tissues, and in osteosarcomas and chondrosarcomas (8336066)	Chiba H.... Matsuyama T.	1993	SPARC, BGLAP
49	Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis. An immunohistochemical analysis of 17 cases. (1463093)	Wojno K.J.... Huvos A.G.	1992	S100B, VIM, MUC1
50	Mesenchymal chondrosarcoma. An immunohistochemical study. (2202275)	Swanson P.E.... Wick M.R.	1990	S100B

Genes related to chondrosarcoma according to GeneCards:

(show top 50)    (show all 221)

id	Symbol	Description	Score	GeneCards Section Context
1	NR4A3	nuclear receptor subfamily 4, group A, member 3	11.1	Functions, Publications, Aliases & Descriptions, Summaries
2	CSAG1	chondrosarcoma associated gene 1	11.1	Publications, Expressions, Transcripts, Proteins (show all 6 sections) Aliases & Descriptions, Summaries
3	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.1	Publications, Summaries
4	TFG	TRK-fused gene	11.1	Publications, Summaries
5	CSAG3	CSAG family, member 3	11.0	Proteins, Publications, Aliases & Descriptions
6	CSAG2	CSAG family, member 2	11.0	Aliases & Descriptions, Proteins, Publications
7	IK	IK cytokine, down-regulator of HLA II	11.0	Aliases & Descriptions
8	VIM	vimentin	11.0	Publications
9	MUC1	mucin 1, cell surface associated	11.0	Publications
10	S100B	S100 calcium binding protein B	11.0	Publications
11	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
12	SIX3	SIX homeobox 3	11.0	Publications
13	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
14	S100A1	S100 calcium binding protein A1	11.0	Publications
15	ESRRB	estrogen-related receptor beta	11.0	Publications
16	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
17	FUS	fused in sarcoma	11.0	Publications
18	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
19	DES	desmin	11.0	Publications
20	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
21	PRPH	peripherin	11.0	Publications
22	TSN	translin	11.0	Publications
23	TDRKH	tudor and KH domain containing	11.0	Publications
24	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
25	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
26	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
27	MTAP	methylthioadenosine phosphorylase	11.0	Publications
28	PLAGL1	pleiomorphic adenoma gene-like 1	11.0	Publications
29	LOC100130935	chondrosarcoma-associated gene 2/3 protein pseudogene	11.0	Aliases & Descriptions
30	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
31	PTHLH	parathyroid hormone-like hormone	11.0	Publications
32	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
33	MAPT	microtubule-associated protein tau	11.0	Functions, Publications
34	COL10A1	collagen, type X, alpha 1	11.0	Publications
35	LECT1	leukocyte cell derived chemotaxin 1	11.0	Expressions, Publications
36	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
37	SYNM	synemin, intermediate filament protein	11.0	Publications
38	EXT2	exostosin 2	11.0	Publications
39	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	11.0	Publications
40	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	11.0	Publications
41	MYOG	myogenin (myogenic factor 4)	11.0	Publications
42	ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	11.0	Publications
43	COL11A2	collagen, type XI, alpha 2	11.0	Publications
44	MYOD1	myogenic differentiation 1	11.0	Publications
45	EXT1	exostosin 1	11.0	Publications
46	ASS1	argininosuccinate synthase 1	11.0	Publications
47	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
48	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
49	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
50	CDK4	cyclin-dependent kinase 4	11.0	Publications

Pathways related to chondrosarcoma according to GeneDecks:

(show top 50)    (show all 320)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.8	BMP2, RAF1, FGF2, FGFR2, FGFR3, MAPK10
2	PTEN Pathway36	10.7	BMP2, FGF2, FGFR1, FGFR2, FGFR3, MET
3	Metalloproteases in connective tissue degradation10	10.5	ITGB5, MMP1, MMP13, MMP14, MMP15, MMP19
4	Colorectal cancer20	10.4	PIK3CB, PIK3CG, TGFB1, TGFB2, TGFB3, TGFBR1
5	CREB Pathway36	10.3	BMP2, BMP6, FGFR1, FGFR2, FGFR3, IL3
6	Paxillin Interactions36	10.0	VCL, BMP2, PARVA, ITGA5, ITGAV, ITGB1
7	UPA-UPAR Pathway36	9.9	ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, MMP1
8	Focal adhesion20	9.9	PIK3CB, PIK3CG, VCL, RAF1, PARVA, PARVB
9	Melanoma20	9.7	PIK3CB, PIK3CG, RB1, RAF1, CDKN1A, CDKN2A
10	ILK Signaling36	9.6	VIM, BMP2, PARVA, PARVB, ITGAV, ITGB1
11	Glioma20	9.5	PIK3CB, PIK3CG, RB1, RAF1, CDKN1A, CDKN2A
12	eNOS Signaling36	9.5	BMP2, BMP6, FGFR1, FGFR2, FGFR3, MET
13	Transendothelial Migration of Leukocytes36	9.4	VCAM1, SDC2, ITGA5, ITGAV, ITGB1, ITGB3
14	14-3-3 Induced Intracellular Signaling36	9.2	BMP2, RAF1, FGF2, FGFR2, FGFR3, IL3
15	Chronic myeloid leukemia20	9.2	PIK3CB, PIK3CG, RB1, RAF1, BCL2L1, CHUK
16	Prostate cancer20	9.0	PIK3CB, PIK3CG, RB1, RAF1, BCL2, CHUK
17	Cell adhesion_ECM remodeling41	9.0	SDC2, CD44, ITGA5, ITGB1, MMP1, MMP13
18	IL-6 Pathway36	9.0	BMP2, BMP6, RAF1, BAX, IL10, IL3
19	Osteoclast differentiation20	8.8	PIK3CB, PIK3CG, CHUK, ITGB3, IL1A, IL1B
20	eIF2 Pathway36	8.8	BMP6, RAF1, FGF2, FGFR1, FGFR2, FGFR3
21	Nuclear Receptor Activation by Vitamin-A36	8.7	BMP2, BMP6, FGF2, FGFR1, FGFR2, FGFR3
22	Rac1 Pathway36	8.5	BMP6, RAF1, ITGA5, ITGAV, ITGB1, ITGB3
23	p70S6K Signaling36	8.5	BMP2, BMP6, RAF1, FGF2, FGFR1, FGFR2
24	PPAR Pathway36	8.5	BMP2, RAF1, ITGA5, ITGAV, ITGB1, ITGB3
25	Activation of PKC through GPCR36	8.4	BMP2, BMP6, RAF1, FGF2, FGFR1, FGFR2
26	Endothelin-1 Signaling Pathway36	8.2	BMP2, BMP6, RAF1, FGFR2, FGFR3, IL10
27	Pathways in cancer20	8.1	PIK3CB, PIK3CG, RB1, VEGFA, BMP2, BCL2
28	Apoptosis20	8.1	PIK3CB, PIK3CG, BCL2, BCL2L1, CHUK, BAX
29	DHA Signaling36	7.9	BMP2, BMP6, BCL2, BCL2L1, BAX, FGF2
30	Estrogen Pathway36	7.9	BMP2, BMP6, RAF1, BCL2, CHUK, FGF2
31	Immune response MIF-mediated glucocorticoid regulation10	7.7	VCAM1, CHUK, MMP1, IL6, IL8, MAPK3
32	Glucocorticoid Receptor Signaling36	7.6	BMP2, BMP6, BCL2, BAX, CDKN1A, IL10
33	p53 Mediated Apoptosis36	7.6	BMP2, BMP6, BCL2, BAX, FGF2, FGFR1
34	Immune response_MIF-mediated glucocorticoid regulation41	7.6	VCAM1, CHUK, MMP1, IL6, IL8, MAPK3
35	Apoptotic Pathways in Synovial Fibroblasts36	7.6	BMP2, BMP6, FGF2, FGFR1, FGFR2, FGFR3
36	ERK Signaling36	7.4	BMP2, BMP6, RAF1, CHUK, ITGA5, ITGAV
37	Molecular Mechanisms of Cancer36	7.4	PIK3CG, RB1, BMP2, BMP6, RAF1, BCL2
38	TGF-Beta Pathway36	7.1	BMP2, BMP6, BCL2, BAX, FGF2, FGFR1
39	MIF Mediated Glucocorticoid Regulation36	6.8	BMP2, BMP6, BCL2, BAX, IL10, IL1A
40	JAK-STAT Pathway36	6.8	BMP2, BMP6, RAF1, BCL2, BAX, FGF2
41	Tuberculosis20	6.8	RAF1, BCL2, BAX, IL10, IL10RA, IL10RB
42	PEDF Induced Signaling36	6.7	BMP2, BMP6, RAF1, BCL2, BCL2L1, CHUK
43	PAK Pathway36	6.6	BMP2, BMP6, BCL2, BAX, FGF2, FGFR1
44	Tec Kinases Signaling36	6.5	BMP2, BMP6, BCL2, BAX, ITGA5, ITGAV
45	Pancreatic Adenocarcinoma36	6.5	RB1, BMP2, BMP6, RAF1, BCL2, BCL2L1
46	Antioxidant Action of Vitamin-C36	6.4	BMP2, BMP6, BCL2, CHUK, BAX, FGF2
47	MAPK Family Pathway36	6.4	BMP2, BMP6, RAF1, BCL2, CHUK, BAX
48	Cytokine-cytokine receptor interaction20	6.3	VEGFA, BMP2, LEP, INHBA, MET, IL10
49	MIF Regulation of Innate Immune Cells36	6.2	BMP2, BMP6, BCL2, BAX, IL10, IL1A
50	p38 Signaling36	5.4	BMP2, BMP6, BCL2, BAX, FGF2, FGFR1

Compounds related to chondrosarcoma according to GeneDecks:

(show top 50)    (show all 403)

id	Compound	Score	Top Affiliating Genes
1	lysine32	11.1	SERPINB2, MYOD1, CHUK, FGFR3, PTHLH, PLAU
2	glycosaminoglycan32	11.1	BMP2, CD36, CD44, MMP13, FGF2, FGFR2
3	estradiol32 9 18 9	14.0	RB1, SERPINA3, VIM, MUC1, XIAP, FST
4	chondroitin sulfate32 18	12.0	VIM, BMP6, CD36, CD44, MMP13, MMP3
5	heparan sulfate32 18	11.8	VIM, BMP2, BMP6, SDC2, LGALS1, CD44
6	glycogen32 18	11.7	PIK3CB, PIK3CG, VIM, CHUK, MUC1, S100A1
7	agar32	10.6	RB1, VIM, LGALS1, MUC1, MTAP, XIAP
8	titanium32	10.6	VIM, VCL, BMP2, BGLAP, CD36, ITGAV
9	phosphatidylserine32 9 9	12.5	VIM, PARP1, BCL2, LGALS1, MAPT, CAPN1
10	manumycin32	10.5	RAF1, CHUK, SRC, NFKBIA, GDNF
11	pge232	10.3	SERPINB2, VCAM1, BMP2, RAF1, FST, MMP1
12	atp32	10.2	PIK3CB, RB1, VCL, MYOD1, PARP1, BCL2L1
13	rottlerin32 42	11.1	PIK3CG, VCAM1, PARP1, XIAP, CD36, IL8
14	arginine32	10.1	SERPINA3, MYOD1, BMP2, BGLAP, LGALS1, LEP
15	dopamine32 9 18 9	13.0	SERPINA3, BMP2, BMP6, RAF1, MTHFR, S100B
16	ceramide32	10.0	RB1, RAF1, BECN1, BCL2L1, LGALS1, XIAP
17	gnrh32	9.9	VIM, RAF1, LEP, FST, MKI67, FGFR1
18	formaldehyde32 18	10.7	RB1, VIM, MUC1, S100B, CD44, MMP1
19	ibmx32	9.6	VCAM1, BMP2, RAF1, FST, MMP2, FGF2
20	oxygen32 18	10.6	RB1, SERPINA3, MYOG, MYOD1, BMP2, BECN1
21	suramin32 9 9	11.5	VEGFA, BMP6, RAF1, FGF2, FGFR1, FGFR2
22	fibrinogen32	9.5	PIK3CB, SERPINB2, SERPINA3, VCAM1, VCL, LEP
23	ang ii32	9.5	PIK3CG, VEGFA, CD36, MAPK3, MAPK10, MAPK1
24	thapsigargin32 42	10.4	PIK3CG, RAF1, BCL2, BCL2L1, CD36, MDM2
25	geldanamycin32 9 9	11.4	PIK3CG, VEGFA, VCL, MYOD1, RAF1, PARP1
26	adenylate32	9.3	PIK3CG, VIM, VCAM1, MYOG, MTAP, S100B
27	p00232	9.2	RB1, LEP, MTHFR, JUP, CD44, MMP13
28	c2ceramide32	9.2	PIK3CG, MYOG, BECN1, PARP1, BCL2L1, CHUK
29	procollagen32	9.1	VIM, BMP2, BMP6, BGLAP, LGALS1, CD36
30	ribonucleic acid32	9.0	SERPINB2, MYOG, BMP2, BMP6, MUC1, FST
31	cysteine32	9.0	SERPINA3, VCL, MYOG, RAF1, BGLAP, PARP1
32	creatinine32	8.9	SERPINA3, MYOG, MYOD1, BMP2, BMP6, LEP
33	testosterone32 9 18 9	11.9	RB1, VIM, VCAM1, VCL, MYOG, MYOD1
34	glutamate32	8.8	PIK3CB, VIM, BMP6, LEP, CHUK, MTHFR
35	suberoylanilide hydroxamic acid32	8.8	RAF1, PARP1, BCL2, BCL2L1, BAX, XIAP
36	matrigel32	8.8	PIK3CG, RB1, SERPINB2, VIM, VEGFA, VCAM1
37	flavopiridol32 9 9	10.6	PIK3CG, RB1, VEGFA, PARP1, BCL2, BCL2L1
38	tgf beta132	8.6	VCAM1, MYOD1, BMP6, FST, CDKN1A, CD36
39	superoxide32 18	9.6	RB1, SERPINB2, SERPINA3, VCAM1, LGALS1, CHUK
40	alanine32	8.5	VCAM1, MYOD1, BMP2, BMP6, RAF1, BGLAP
41	rosiglitazone32 9 18 9	10.7	PIK3CG, VCAM1, LEP, CDKN1A, CD36, MMP1
42	irinotecan32 34 9 9	10.6	VEGFA, PARP1, BCL2L1, BAX, MTHFR, CEACAM3
43	5fluorouracil32	7.3	PIK3CG, RB1, VEGFA, BCL2, BCL2L1, CHUK
44	lactate32	7.3	VIM, VCAM1, BMP2, BMP6, S100B, CEACAM3
45	hydrocortisone32 9 9	9.2	VIM, BMP6, BGLAP, MUC1, CD36, MMP1
46	15-deoxy-delta-12,14-prostaglandin j232	7.0	PIK3CG, VEGFA, VCAM1, BMP6, BCL2L1, CDKN1A
47	methotrexate32 34 42 9 9	10.7	RB1, SERPINA3, VIM, BMP6, LEP, MUC1
48	parthenolide32	6.6	PIK3CG, VCAM1, BCL2L1, CHUK, MMP9, IL6
49	indomethacin32 9 9	8.1	VIM, BMP2, BMP6, RAF1, LGALS1, LEP
50	actinomycin d32	4.0	PIK3CG, RB1, SERPINB2, VIM, VEGFA, MYOD1

Cellular components related to chondrosarcoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	focal adhesion	GO:005925	10.3	PTK2, EZR, MAPK1, MAPK3, FBLIM1, FERMT2
2	proteinaceous extracellular matrix	GO:005578	10.1	SPARC, CTGF, TGFB1, ADAMTS1, ADAMTS8, ADAMTS9
3	caveola	GO:005901	9.6	EFNA5, SMO, CTSB, SRC, PTGS2, PTCH1
4	nucleoplasm	GO:005654	9.4	PPARG, TERT, TP53, ESRRB, ESR2, AKT1
5	external side of plasma membrane	GO:009897	9.3	CXCL12, CTSB, TNFRSF11A, TNF, ICAM1, ITGB1
6	cell surface	GO:009986	8.4	TNF, PLAU, PLAUR, ABCB1, TIMP2, TGFA
7	cytoplasm	GO:005737	8.2	PTH1R, PTHLH, PTK2, DAPK1, SPINT2, NR1H2
8	plasma membrane	GO:005886	8.1	SRC, CTGF, PPFIBP1, SMO, PLAU, PLAUR
9	cytosol	GO:005829	7.8	AKT1, TP53, PTK2, SRC, CTGF, PPARG
10	extracellular region	GO:005576	7.3	TGFB2, TGFB3, CXCL12, ADAM28, GDNF, SERPINB2
11	extracellular space	GO:005615	5.7	MMP2, MMP3, MMP7, MMP9, FGF2, FGF9
12	nucleus	GO:005634	INF	, SRC, SPARC, PPARG, NR1H2, NR4A3

Biological processes related to chondrosarcoma according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	chondrocyte differentiation	GO:002062	10.7	FGFR3, PTH1R, PRKCA, TGFB1, FGF9, COL2A1
2	peptidyl-tyrosine phosphorylation	GO:018108	10.6	FGFR3, PTK2, SRC, PDGFRA, PDGFRB, ABL1
3	cartilage development	GO:051216	10.6	BMP6, SOX9, HIF1A, COL2A1, BMP2, CD44
4	fibroblast growth factor receptor signaling pathway	GO:008543	10.5	MDM2, FGFR1, FGF3, FGF9, FGFR2, FGFR3
5	proteolysis	GO:006508	10.5	CAPN1, CASP6, CAPN2, CTSK, CTSB, ADAMTS1
6	axon guidance	GO:007411	10.5	MAPK1, MET, MAPK3, FGFR1, ITGB3, ITGB1
7	extracellular matrix disassembly	GO:022617	10.3	TIMP2, MMP9, TIMP1, MMP7, MMP3, MMP2
8	response to wounding	GO:009611	10.3	MET, F2RL3, TGFB2, TGFB1, GFAP, AGER
9	positive regulation of cell migration	GO:030335	10.3	CSF1R, TGFB1, PDPN, PDGFRB, PDGFRA, VEGFA
10	skeletal system development	GO:001501	10.3	COL2A1, COL10A1, MMP9, FGFR1, IGF2, IGF1
11	insulin receptor signaling pathway	GO:008286	10.2	MAPK1, FGFR1, FGFR2, FGFR3, MAPK3, FGF3
12	ossification	GO:001503	10.2	CTGF, BCL2, MMP9, IGF2, EXT2, TNFRSF11A
13	wound healing	GO:042060	10.2	TGFB2, TGFBR1, IL1A, PDGFRA, IL1B, RAF1
14	extracellular matrix organization	GO:030198	10.1	MMP14, MMP3, MMP7, MMP9, TNF, PTK2
15	angiogenesis	GO:001525	10.0	PIK3CG, VEGFA, ITGA5, ITGAV, MMP19, MMP2
16	collagen catabolic process	GO:030574	10.0	MMP13, MMP9, MMP7, MMP3, MMP2, MMP19
17	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	CSF1R, CHI3L1, PDGFRA, CD44, FGF2, FGFR2
18	platelet degranulation	GO:002576	9.9	TGFB2, TGFB1, ITGB3, SPARC, HSPA5, IGF1
19	positive regulation of cell division	GO:051781	9.7	FGF9, TGFB2, TGFB1, TGFA, IL1B, IGF2
20	signal transduction	GO:007165	9.6	CDK4, FGF2, FGF3, FGF9, MET, IL10RA
21	positive regulation of endothelial cell proliferation	GO:001938	9.6	FGF2, CCL2, ITGB3, PRKCA, BMP6, VEGFA
22	cellular response to interleukin-1	GO:071347	9.6	CHI3L1, HIF1A, NFKB1, ICAM1, CCL2, IL8
23	activation of MAPK activity	GO:000187	9.5	MAPK10, PIK3CB, FGF2, MET, MAPK3, IL1B
24	response to mechanical stimulus	GO:009612	9.5	PRKCA, MMP9, BMP2, CXCL12, CTSB, TNF
25	virus-host interaction	GO:019048	9.4	PDGFRA, TGFB1, CXCR4, BECN1, RB1, NFKBIA
26	positive regulation of mitosis	GO:045840	9.4	PDGFRB, TGFA, MET, IL1A, IL1B, IGF2
27	response to estradiol stimulus	GO:032355	9.3	PTGS2, CTGF, TGFB1, TGFB2, PRKCA, ENO2
28	positive regulation of MAPK cascade	GO:043410	9.3	FGFR2, FGFR1, FGF9, ITGB1, CD36, LEP
29	positive regulation of protein phosphorylation	GO:001934	9.2	CSF1R, BMP2, ITGB3, IL1B, MAPK3, AKT1
30	induction of apoptosis by intracellular signals	GO:008629	9.2	PRKCA, TP53, BCL2, AKT1, CASP3, CDKN1A
31	induction of apoptosis	GO:006917	9.1	TNF, PDCD5, BAX, CDKN2A, INHBA, DAPK1
32	MAPK cascade	GO:000165	9.1	RAF1, FGFR1, FGFR3, IL1B, MAPK3, MAPK1
33	Ras protein signal transduction	GO:007265	9.1	CDKN2A, CDKN1A, FGF2, RB1, MAPK3, MAPK1
34	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.5	HDAC4, SMO, E2F1, HDAC9, TGFB1, CD36
35	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.5	ESR2, JUP, AKT1, IL6, IL10, TNF
36	platelet activation	GO:030168	8.5	PIK3CB, PIK3CG, VEGFA, VCL, RAF1, CD36
37	anti-apoptosis	GO:006916	8.5	SERPINB2, BECN1, BCL2, BCL2L1, MUC1, XIAP
38	blood coagulation	GO:007596	8.5	ITGB3, TGFB1, TGFB2, TGFB3, PRKCA, TIMP1
39	apoptotic process	GO:006915	8.4	BAX, XIAP, FGF2, FGFR2, CASP6, CASP3
40	positive regulation of cell proliferation	GO:008284	8.4	VEGFA, BCL2L1, LEP, T, CDK4, ITGAV
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.4	IL1B, IL6, IKBKB, NFKB1, ICAM1, TNF
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.3	TP53, VEGFA, ITGA5, ITGB1, ITGB3, CD44
43	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.2	CD44, RAF1, MET, VEGFA, IL6, TGFB1
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.5	RB1, VEGFA, MYOG, MYOD1, BMP2, BMP6
45	response to drug	GO:042493	7.5	CSAG2, MET, IL10, ENO2, CCL2, IKBKB
46	positive regulation of transcription, DNA-dependent	GO:045893	7.5	HIF1A, IL6, RUNX2, SOX9, TAF15, TGFBR1
47	response to hypoxia	GO:001666	7.4	HIF1A, TGFB3, CXCL12, CXCR4, LEP, TGFB2
48	negative regulation of cell proliferation	GO:008285	7.2	BMP2, RAF1, BECN1, CDKN1A, CDKN2B, CDKN2A
49	inflammatory response	GO:006954	7.0	F2R, AKT1, TNF, PTGS2, SPP1, NFKB1
50	negative regulation of apoptotic process	GO:043066	7.0	TNF, PTK2, CYR61, PLAUR, COL2A1, TIMP1

Molecular functions related to chondrosarcoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	metalloendopeptidase activity	GO:004222	10.4	ADAMTS1, ADAMTS8, ADAMTS9, ADAM28, ADAMTS15, ADAMTS4
2	integrin binding	GO:005178	9.7	CTGF, GFAP, TIMP2, ADAMTS8, ADAMTS5, SRC
3	protein homodimerization activity	GO:042803	9.0	EXT1, EXT2, TERT, PTGS2, NOS2, NFKB1
4	identical protein binding	GO:042802	9.0	AKT1, TP53, TNF, COL2A1, NFKBIA, TGFB3
5	protein heterodimerization activity	GO:046982	8.8	BMP2, MYOD1, MYOG, VEGFA, BMP6, CAPN2
6	cytokine activity	GO:005125	7.3	IL6, TNF, TNFSF11, SPP1, TGFB2, CSF3
7	growth factor activity	GO:008083	7.1	GDNF, IL6, IL3, IL1B, IL10, FGF9
8	protein binding	GO:005515	5.1	NUP107, CXCR4, PRKCA, DES, SYNM, TAF15