MCID: CHN012
MIFTS: 63

Chondrosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Chondrosarcoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A connective tissue cancer that has physical basis in cells derived from transformed cells that produce cartilage.

MalaCards: Chondrosarcoma, also known as primary chondrosarcoma of the bone, is related to mesenchymal chondrosarcoma and extraskeletal myxoid chondrosarcoma. An important gene associated with Chondrosarcoma is EXT1 (exostosin glycosyltransferase 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related mouse phenotype behavior/neurological.

Wikipedia:63 Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.... more...

Description from OMIM:46 215300

Aliases & Classifications for Chondrosarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
chondrosarcoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

chondrosarcoma 8 9 42 22 46 10 44 48 60
primary chondrosarcoma of the bone 8
primary chondrosarcoma of bone 8
chondrosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3371
MeSH34 D002813
NCIt39 C2946
OMIM46 215300
SNOMED-CT via Orphanet57 447792005, 443520009
MESH via Orphanet35 D002813
UMLS via Orphanet61 C0008479

Related Diseases for Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Chondrosarcoma family:

Localized Chondrosarcoma

Diseases related to Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1mesenchymal chondrosarcoma31.6VIM, DES, MUC1
2extraskeletal myxoid chondrosarcoma31.4TAF15, NR4A3, TFG
3osteosarcoma30.8EXT1, CD36
4chordoma30.7MUC1, DES, S100A1, S100B, VIM
5sarcoma30.7VIM, EXT1, S100B, S100A1, SMARCB1, FUS
6giant cell tumor30.2VIM, S100B, DES, MUC1
7fibrosarcoma30.2CD36, DES, VIM
8rhabdomyosarcoma30.1VIM, S100B, S100A1, EWSR1, DES, ENO2
9synovial sarcoma30.0MUC1, DES, S100B, VIM
10osteoarthritis29.9CD36, S100A1
11leiomyosarcoma29.7VIM, S100B, S100A1, DES, MUC1, ENO2
12hemangiopericytoma29.7VIM, S100B, S100A1, DES, MUC1
13meningioma29.7VIM, S100B, S100A1, MUC1, SMARCB1
14liposarcoma29.7VIM, EWSR1, DES, FUS
15alveolar soft part sarcoma29.7VIM, DES, ENO2
16clear cell sarcoma29.7FUS, EWSR1, S100B
17lipoma29.7S100A1, DES, FUS
18adenoma29.7S100A1, MUC1, ENO2
19angiosarcoma29.7MUC1, VIM
20myxoid liposarcoma29.7EWSR1, FUS
21myxoid chondrosarcoma11.0
22clear cell chondrosarcoma10.7
23intracranial chondrosarcoma10.7
24extraskeletal mesenchymal chondrosarcoma10.7
25periosteal chondrosarcoma10.5
26periostitis10.5
27juxtacortical chondrosarcoma10.5
28localized chondrosarcoma10.4
29chondroma10.4
30cervicitis10.4
31extraosseous chondrosarcoma10.3
32laryngitis10.3
33hereditary multiple exostoses10.3
34pediatric mesenchymal chondrosarcoma10.3
35exostosis10.3
36meningitis10.3
37chondroblastoma10.2
38adult mesenchymal chondrosarcoma10.2
39ollier disease10.2
40bone osteosarcoma10.2
41chondroid chordoma10.2
42chondroblastic osteosarcoma10.1
43pediatric myxoid chondrosarcoma10.1
44adult myxoid chondrosarcoma10.1
45thyroiditis10.1
46localized osteosarcoma10.1
47adult extraosseous chondrosarcoma10.1
48paget's disease of bone10.1
49melanoma10.0VIM, S100B, S100A1, EWSR1, DES, CD36
50malignant mixed mullerian tumor10.0VIM, S100B, S100A1, DES, MUC1, ENO2

Graphical network of the top 20 diseases related to Chondrosarcoma:



Diseases related to chondrosarcoma

Clinical Features for Chondrosarcoma

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46OMIM
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Clinical features from OMIM:

215300

Clinical synopsis from OMIM:

215300

Drugs & Therapeutics for Chondrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Chondrosarcoma

Search NIH Clinical Center for Chondrosarcoma

Search CenterWatch for Chondrosarcoma

Genetic Tests for Chondrosarcoma

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22GTR
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Genetic tests related to Chondrosarcoma:

id Genetic test Affiliating Genes
1 Chondrosarcoma22

Anatomical Context for Chondrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Chondrosarcoma:

32
Bone, Lung, Breast, Endothelial, Kidney, Thyroid, Pancreas, Heart, Liver, Brain, Spinal cord, Cerebellum, Bone marrow, Testis, T cells, Trachea, Colon, Skin, Uterus, Spleen, Lymph node, Tongue, Ovary, Pineal

Animal Models for Chondrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.3FUS, EXT1, S100B, S100A1, DES, NR4A3

Publications for Chondrosarcoma

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50PubMed
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Articles related to Chondrosarcoma:

(show top 50)    (show all 1225)
idTitleAuthorsYear
1
Analysis of microRNAs expressions in chondrosarcoma. (23940002)
2013
2
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
3
Chondrosarcoma of the mandibular condyle in a patient with Werner syndrome: a case report. (23357132)
2013
4
Diffusion-weighted MRI: distinction of skull base chordoma from chondrosarcoma. (23124635)
2013
5
Dosimetric comparison of photon and proton treatment techniques for chondrosarcoma of thoracic spine. (23541524)
2013
6
Primary mesenchymal chondrosarcoma of the kidney with synchronous implant and infiltrating urothelial carcinoma of the ureter. (22999069)
2012
7
Intramedullary chondrosarcoma of proximal humerus. (23243546)
2012
8
Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma. (21804475)
2011
9
Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78. (20890703)
2011
10
Chondrosarcoma of the foot. (21720585)
2011
11
Intralesional curettage, with phenol and cement as adjuvants, for low-grade intramedullary chondrosarcoma of the long bones. (22187844)
2011
12
Non-skeletal multicentric chondrosarcoma in the hindlimb of a dog. (21029099)
2010
13
Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization. (19596254)
2009
14
Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. (19126648)
2009
15
Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro. (18624751)
2009
16
Extraskeletal myxoid chondrosarcoma: Diagnosis of a rare soft tissue tumor based on fine needle aspiration cytology. (21938148)
2009
17
Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. (19968226)
2009
18
Development of chondrosarcoma animal models for assessment of adjuvant therapy. (19566512)
2009
19
Mesenchymal chondrosarcoma mimicking apical periodontitis. (18928860)
2008
20
Chondrosarcoma and peroxisome proliferator-activated receptor. (18725985)
2008
21
Myxoid chondrosarcoma in the calcaneus: a case report with MR imaging findings. (17219232)
2007
22
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. (17343283)
2007
23
Extraskeletal mesenchymal chondrosarcoma of the cervical meninx. (17705006)
2007
24
Survivorship analysis in patients with periosteal chondrosarcoma. (16826117)
2006
25
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
26
Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue]. (17068623)
2006
27
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. (15744499)
2005
28
Primary intradural myxoid chondrosarcoma: a case report and review in the literature. (16283441)
2005
29
Evaluation of p16 and Id1 status and endogenous reference genes in human chondrosarcoma by real-time PCR. (16273214)
2005
30
An institutional review of clear cell chondrosarcoma. (16239809)
2005
31
Expression of the chondromodulin-I gene in chondrosarcomas. (14744535)
2004
32
Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. (12792311)
2003
33
Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. (11777908)
2002
34
Imaging of an exceptional tumor: myxoid chondrosarcoma of the jugular foramen. (12412972)
2001
35
Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes. (10937620)
2000
36
Musculoskeletal case of the day. Clear cell chondrosarcoma. (10470928)
1999
37
De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma. (9726043)
1998
38
Der(16)t(1;16)(q21;q13) as a secondary structural aberration in yet a third sarcoma, extraskeletal myxoid chondrosarcoma. (9408761)
1997
39
Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas. (8689637)
1996
40
Extraskeletal myxoid chondrosarcoma. A clinicopathologic study of ten patients with long-term follow-up. (1451062)
1992
41
Orbital mesenchymal chondrosarcoma. (1636546)
1992
42
Extraskeletal mesenchymal chondrosarcoma of the mediastinum. (2242853)
1990
43
Case report 517. Mesenchymal chondrosarcoma of the femur. (2749290)
1989
44
Nonrandom translocation in extraskeletal myxoid chondrosarcoma. (3567883)
1987
45
Mesenchymal chondrosarcoma in the young. (6402853)
1983
46
Chordoid sarcoma (extraskeletal myxoid chondrosarcoma). (6402851)
1983
47
A case of mesenchymal chondrosarcoma of the orbit. (7211271)
1980
48
Intracranial mesenchymal chondrosarcoma. (7434199)
1980
49
Chondrosarcoma of the first metatarsal--primary or secondary to enchondroma? (398208)
1979
50
MESENCHYMAL CHONDROSARCOMA. (14161087)
1964

Genetic Variations for Chondrosarcoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Chondrosarcoma:

62
id Symbol AA change Variation ID SNP ID
1EXT1p.Asn316SerVAR_012820

Expression for genes affiliated with Chondrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chondrosarcoma

Search GEO for disease gene expression data for Chondrosarcoma.

Pathways for genes affiliated with Chondrosarcoma

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29KEGG
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Pathways related to Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FUS, TAF15, NR4A3, EWSR1

Compounds for genes affiliated with Chondrosarcoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Chondrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.6EWSR1, ESRRB, MUC1, CD36, ENO2, S100B
2tyrosine4411.6S100B, MUC1, NR4A3, S100A1, EWSR1, TFG
3paraffin4411.6ENO2, EWSR1, DES, S100A1, S100B, VIM
4progesterone44 59 28 11 2415.5DES, S100B, ESRRB, ENO2, MUC1, S100A1
5hematoxylin4411.4VIM, ENO2, MUC1, DES, S100A1, S100B
6heparin44 28 11 2414.4ENO2, DES, S100B, EXT1, VIM, CD36
7dexamethasone44 49 28 1114.3ESRRB, MUC1, S100B, ENO2, CD36, VIM
8s 1004411.3VIM, ENO2, MUC1, DES, S100B
9mucicarmine4411.3VIM, MUC1, DES, S100B, S100A1
10b 7234411.3VIM, MUC1, DES, S100A1, S100B
11vegf4411.3VIM, ENO2, CD36, MUC1, DES, S100B
12hyaluronic acid44 2412.3DES, VIM, ENO2, MUC1, CD36
13formaldehyde44 2412.3MUC1, DES, ENO2, S100B, VIM
14glutamine4411.2VIM, S100B, ENO2, CD36, EWSR1
15reticulin4411.2MUC1, VIM, S100B, DES
16iron44 2412.2S100B, DES, VIM, ENO2, S100A1
17toluidine4411.2S100A1, VIM, DES, ENO2
18biotin44 11 2413.2DES, MUC1, S100A1, VIM
19adriamycin4411.2MUC1, CD36, DES, VIM
20bromodeoxyuridine4411.2DES, VIM, ENO2, S100B
21cyclic amp44 2412.2DES, EWSR1, VIM, MUC1, S100B
22dmso4411.1ENO2, CD36, MUC1, VIM
23orcein4411.1DES, S100B, VIM
24eosin4411.1VIM, MUC1, S100B
25acth4411.1ESRRB, S100B, MUC1, ENO2
26cysteine4411.1CD36, S100A1, MUC1, DES, S100B, VIM
27hydroxyapatite4411.0VIM, S100B, CD36
28acetylcholine44 49 28 11 2415.0ENO2, S100A1
294-hydroxytamoxifen4411.0VIM, ESRRB, S100B
30askin4411.0ENO2, EWSR1
31ganglioside4411.0VIM, DES, ENO2
32procollagen4411.0DES, CD36, VIM
33creatinine4411.0CD36
34nor 14411.0EWSR1, NR4A3
35dbc-amp4411.0VIM, S100B, ENO2
36edss4410.9S100B, ENO2
37silver4410.9DES, S100A1, ENO2
38progestin4410.9MUC1, DES, VIM
39testosterone44 59 11 2413.9VIM, S100B, MUC1, ENO2, DES
40olopatadine44 1111.8S100B, S100A1
41cytarabine44 49 1112.7MUC1, CD36, VIM
422-methoxyethanol4410.7VIM, S100A1
43catecholamine4410.6ENO2, S100B, VIM
44tartrate4410.3VIM, CD36

GO Terms for genes affiliated with Chondrosarcoma

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16Gene Ontology
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Molecular functions related to Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.8FUS, VIM, S100B, S100A1, EWSR1, TFG
2S100 protein bindingGO:04454810.6S100A1, S100B

Products for genes affiliated with Chondrosarcoma

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Sources for Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet