MCID: CHN056
MIFTS: 44

Chondrosarcoma, Extraskeletal Myxoid

Categories: Genetic diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Chondrosarcoma, Extraskeletal Myxoid

MalaCards integrated aliases for Chondrosarcoma, Extraskeletal Myxoid:

Name: Chondrosarcoma, Extraskeletal Myxoid 53 13 41
Extraskeletal Myxoid Chondrosarcoma 12 55 36 14 69
Myxoid Extraosseous Chondrosarcoma 12
Emc 53

Characteristics:

Orphanet epidemiological data:

55
extraskeletal myxoid chondrosarcoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

HPO:

31
chondrosarcoma, extraskeletal myxoid:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 53 612237
Disease Ontology 12 DOID:6496
MeSH 41 C563195
NCIt 46 C27502
SNOMED-CT 64 404079008
Orphanet 55 ORPHA209916
UMLS via Orphanet 70 C1275278
ICD10 via Orphanet 33 C49.9
MedGen 39 C1275278
KEGG 36 H00053
SNOMED-CT via HPO 65 124975008 14990007 443520009
UMLS 69 C1275278

Summaries for Chondrosarcoma, Extraskeletal Myxoid

OMIM : 53 Extraskeletal myxoid chondrosarcoma is a rare soft tissue neoplasm of chondroblastic origin. The tumors are most commonly found in middle-aged and elderly individuals, are more common among men, and are often detected as deep-seated lesions in the extremities. Despite their relatively low-grade malignancy, recurrence and metastasis may appear many years after the initial diagnosis. Histologic tissue section examination reveals a mixture of cellular and myxoid stromal components (Panagopoulos et al., 2002). (612237)

MalaCards based summary : Chondrosarcoma, Extraskeletal Myxoid, also known as extraskeletal myxoid chondrosarcoma, is related to epithelial-myoepithelial carcinoma and myxoid chondrosarcoma, and has symptoms including chondrosarcoma An important gene associated with Chondrosarcoma, Extraskeletal Myxoid is NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Related phenotype is shRNA abundance <= 50%.

Disease Ontology : 12 An extraosseous chondrosarcoma that has material basis in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix.

Related Diseases for Chondrosarcoma, Extraskeletal Myxoid

Diseases related to Chondrosarcoma, Extraskeletal Myxoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 32.6 NR4A3 SMARCB1 TAF15
2 myxoid chondrosarcoma 31.8 EWSR1 NR4A3 TAF15
3 chondrosarcoma 31.2 ENO2 EWSR1 NR4A3 TAF15 TFG
4 extraosseous chondrosarcoma 31.0 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
5 small cell osteogenic sarcoma 10.6 ENO2 EWSR1
6 malignant sertoli cell tumor 10.5 ENO2 SYP
7 urinary bladder small cell neuroendocrine carcinoma 10.5 ENO2 SYP
8 askin's tumor 10.5 ENO2 EWSR1
9 sinonasal undifferentiated carcinoma 10.5 ENO2 SYP
10 auditory system cancer 10.5 ENO2 SYP
11 cutaneous ganglioneuroma 10.5 ENO2 SYP
12 large cell carcinoma with rhabdoid phenotype 10.5 ENO2 SMARCB1
13 sensory organ benign neoplasm 10.5 ENO2 SYP
14 middle ear adenoma 10.5 ENO2 SYP
15 gallbladder small cell carcinoma 10.5 ENO2 SYP
16 melanotic medulloblastoma 10.5 ENO2 SMARCB1
17 pancreatic somatostatinoma 10.5 ENO2 SYP
18 extrahepatic bile duct adenocarcinoma 10.5 ENO2 SYP
19 small cell carcinoma of the bladder 10.5 ENO2 SYP
20 papillary tumor of the pineal region 10.5 ENO2 SYP
21 ovarian carcinosarcoma 10.5 ENO2 SYP
22 pulmonary large cell neuroendocrine carcinoma 10.5 ENO2 SYP
23 atypical follicular adenoma 10.5 ENO2 SYP
24 epithelioid malignant peripheral nerve sheath tumor 10.5 ENO2 SMARCB1
25 central nervous system primitive neuroectodermal neoplasm 10.5 ENO2 SYP
26 rhabdoid meningioma 10.5 SMARCB1 SYP
27 cerebellum cancer 10.5 ENO2 SYP
28 vulvar sarcoma 10.5 EWSR1 SMARCB1
29 subependymal glioma 10.5 ENO2 SYP
30 peritoneal serous adenocarcinoma 10.5 SYP WT1
31 olfactory nerve neoplasm 10.4 ENO2 SYP
32 cerebral neuroblastoma 10.4 ENO2 SYP
33 epithelioid cell melanoma 10.4 ENO2 WT1
34 benign ependymoma 10.4 ENO2 SYP
35 malignant teratoma 10.4 ENO2 SYP
36 astroblastoma 10.4 ENO2 SYP
37 orbital cancer 10.4 ENO2 EWSR1 SYP
38 juxtacortical chondroma 10.4 EWSR1 FUS
39 olfactory neuroblastoma 10.4 ENO2 EWSR1 SYP
40 myxofibrosarcoma 10.4 CREB3L2 FUS
41 pineal gland cancer 10.4 ENO2 SYP
42 ovarian small cell carcinoma 10.4 SYP WT1
43 endometrial small cell carcinoma 10.4 ENO2 SYP
44 sclerosing liposarcoma 10.4 CREB3L2 FUS
45 cell type cancer 10.4 ENO2 EWSR1 SYP
46 melanotic neuroectodermal tumor 10.4 ENO2 SYP
47 pancoast tumor 10.4 CREB3L2 ENO2
48 bone ewing's sarcoma 10.4 ENO2 EWSR1 WT1
49 cerebral ventricle cancer 10.4 ENO2 SMARCB1 SYP
50 cerebrum cancer 10.4 ENO2 SMARCB1 SYP

Graphical network of the top 20 diseases related to Chondrosarcoma, Extraskeletal Myxoid:



Diseases related to Chondrosarcoma, Extraskeletal Myxoid

Symptoms & Phenotypes for Chondrosarcoma, Extraskeletal Myxoid

Clinical features from OMIM:

612237

Human phenotypes related to Chondrosarcoma, Extraskeletal Myxoid:

31
# Description HPO Frequency HPO Source Accession
1 chondrosarcoma 31 HP:0006765

GenomeRNAi Phenotypes related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1

Drugs & Therapeutics for Chondrosarcoma, Extraskeletal Myxoid

Drugs for Chondrosarcoma, Extraskeletal Myxoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
7 Alkylating Agents Phase 3,Phase 2
8 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
9 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
10 Isophosphamide mustard Phase 3,Phase 2 0
11 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
12
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
13
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
14
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
15
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
16
Gemcitabine Approved Phase 2 95058-81-4 60750
17 Antibodies Phase 2,Phase 1
18 Antibodies, Monoclonal Phase 2,Phase 1
19 Immunoglobulins Phase 2,Phase 1
20 insulin Phase 2
21 Insulin, Globin Zinc Phase 2
22 Mitogens Phase 2
23 Angiogenesis Inhibitors Phase 2
24 Angiogenesis Modulating Agents Phase 2
25 Immunosuppressive Agents Phase 2
26 Anti-Infective Agents Phase 2
27 Antimetabolites Phase 2
28 Antimetabolites, Antineoplastic Phase 2
29 Antiviral Agents Phase 2
30 lysine Nutraceutical Phase 2,Phase 1

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
3 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
6 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
7 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
8 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
9 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
10 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
11 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Recruiting NCT02066285 Phase 2 Pazopanib
12 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
13 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
14 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
15 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Active, not recruiting NCT00589121 Phase 2 Chemotherapy
16 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
17 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
18 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Chondrosarcoma, Extraskeletal Myxoid

Cochrane evidence based reviews: chondrosarcoma, extraskeletal myxoid

Genetic Tests for Chondrosarcoma, Extraskeletal Myxoid

Anatomical Context for Chondrosarcoma, Extraskeletal Myxoid

Publications for Chondrosarcoma, Extraskeletal Myxoid

Articles related to Chondrosarcoma, Extraskeletal Myxoid:

(show top 50) (show all 185)
# Title Authors Year
1
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
2
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
3
Curious case of extraskeletal myxoid chondrosarcoma. ( 28360467 )
2017
4
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. ( 28249774 )
2017
5
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
6
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2017
7
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. ( 28638563 )
2017
8
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. ( 29390404 )
2017
9
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. ( 28383167 )
2017
10
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. ( 29381948 )
2017
11
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
12
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2016
13
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
14
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
15
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
16
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2016
17
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
18
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
19
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
20
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
21
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
22
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
23
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
24
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
25
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
26
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
27
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
28
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
29
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
30
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
31
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
32
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
33
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
34
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
35
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
36
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
37
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
38
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. ( 24185117 )
2013
39
A novel sarcoma with dual differentiation: clinicopathologic and molecular characterization of a combined synovial sarcoma and extraskeletal myxoid chondrosarcoma. ( 22743288 )
2012
40
Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma. ( 22592656 )
2012
41
Primary intracranial extraskeletal myxoid chondrosarcoma. ( 22426765 )
2012
42
Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. ( 23058004 )
2012
43
Multicentric extraskeletal myxoid chondrosarcoma of uterine adnexa in a young female: an unusual presentation. ( 22499307 )
2012
44
The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC. ( 22581839 )
2012
45
Extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old Irish setter dog. ( 22446404 )
2012
46
Extraskeletal myxoid chondrosarcoma of the thigh with a t(9;17) translocation. ( 22740963 )
2012
47
Extraskeletal myxoid chondrosarcoma with small bowel metastasis causing bowel obstruction. ( 23213584 )
2012
48
Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia. ( 22925697 )
2012
49
Intra-articular extraskeletal myxoid chondrosarcoma of the ankle. ( 22438126 )
2012
50
Chromosomal translocation-negative cellular extraskeletal myxoid chondrosarcoma in an adolescent female. ( 22804337 )
2012

Variations for Chondrosarcoma, Extraskeletal Myxoid

Cosmic variations for Chondrosarcoma, Extraskeletal Myxoid:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM5324 PTEN bone,extraskeletal,chondrosarcoma,myxoid c.522T>G p.Y174* 16

Expression for Chondrosarcoma, Extraskeletal Myxoid

Search GEO for disease gene expression data for Chondrosarcoma, Extraskeletal Myxoid.

Pathways for Chondrosarcoma, Extraskeletal Myxoid

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to KEGG:

36
# Name Kegg Source Accession
1 Transcriptional misregulation in cancer hsa05202

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 EWSR1 FUS SMARCB1 SS18 TAF15
2 11.44 DDIT3 EWSR1 FUS NR4A3 SS18 TAF15

GO Terms for Chondrosarcoma, Extraskeletal Myxoid

Cellular components related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.85 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1
2 nucleus GO:0005634 9.53 CREB3L2 DDIT3 EWSR1 FUS MKL2 NPM3
3 npBAF complex GO:0071564 8.96 SMARCB1 SS18

Biological processes related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.77 CREB3L2 MKL2 NR4A2 TCF12 WT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.7 CREB3L2 DDIT3 NR4A2 NR4A3 TAF15 TCF12
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 CREB3L2 DDIT3 MKL2 NR4A2 NR4A3 SMARCB1
4 regulation of transcription, DNA-templated GO:0006355 9.44 CREB3L2 DDIT3 EWSR1 FUS MKL2 NR4A2
5 cellular response to corticotropin-releasing hormone stimulus GO:0071376 9.32 NR4A2 NR4A3
6 transcription, DNA-templated GO:0006351 10 CREB3L2 DDIT3 EWSR1 MKL2 NR4A2 NR4A3

Molecular functions related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.7 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 WT1
2 DNA binding GO:0003677 9.7 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1
3 transcription coactivator activity GO:0003713 9.67 FUS MKL2 SMARCB1 SS18
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.65 DDIT3 NR4A2 NR4A3 SMARCB1 TCF12
5 transcription regulatory region DNA binding GO:0044212 9.62 CREB3L2 DDIT3 TCF12 WT1
6 retinoid X receptor binding GO:0046965 9.46 FUS NR4A2
7 glucocorticoid receptor binding GO:0035259 9.43 NR4A2 NR4A3
8 cAMP response element binding GO:0035497 9.4 CREB3L2 TCF12
9 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.1 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 WT1
10 protein binding GO:0005515 10.38 DDIT3 ENO2 EWSR1 FUS MKL2 NPM3
11 RNA binding GO:0003723 10.04 EWSR1 FUS NPM3 SNRPC TAF15 WT1

Sources for Chondrosarcoma, Extraskeletal Myxoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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