Chordoma malady

NIH Rare Diseases: A chordoma is a rare tumor that develops from cells of the notochord, a structure that is present in the developing embryo and is important for the development of the spine.  The notochord usually disappears before birth, though a few cells may remain embedded in the bones of the spine or at the base of the skull.  A chordoma occurs when these notochord cells start to grow into a tumor and spread into surrounding bone.  Approximately one third of chordomas occur at the base of the skull in a bone called the clivus and the most common symptoms are double vision (diplopia) and headaches.  The average age of diagnosis for chordomas of the skull base is 38 years.   Treatment often begins with surgery to remove as much of the tumor as possible, and radiation therapy may follow surgery to destroy any remaining tumor cells.  Chordomas often grow back in the original location after treatment (known as a recurrence); they do not often spread to distant parts of the body (metastasize).  Though the cause of chordomas is unknown, there is currently a study aimed at identifying a potential genetic predisposition to this disease; more information on this study can be found on the National Cancer Institute's web site.³⁰

MalaCards: Chordoma, also known as chordoma (morphologic abnormality), is related to chondroid chordoma and parachordoma. An important gene associated with Chordoma is CHDM (Chordoma), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeleton remodeling_Keratin filaments. The compounds egcg and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, lung and thyroid, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A notochordal cancer that derives from cellular remnants of the notochord.⁶

Genetics Home Reference: A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordomas grow slowly, gradually extending into the bone and soft tissue around them. They often recur after treatment, and in about 40 percent of cases the cancer spreads (metastasizes) to other areas of the body, such as the lungs.¹⁷

Wikipedia: Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The...⁴⁴ more...

Aliases & Descriptions:

chordoma 6 7 30 16 17 8 33 32 43 chordoma (morphologic abnormality) 6

notochordoma 6

Diseases related to chordoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 760)

id	Related Disease	Score	Top Affiliating Genes
1	chondroid chordoma	34.4	VIM, MUC1, S100A1, S100B, CEACAM3, MFGE8
2	parachordoma	31.1	VIM, MUC1, S100B, T, CEACAM3, KRT8
3	myxopapillary ependymoma	30.0	NCAM1, VIM, LGALS3, MUC1, S100B, KRT7
4	fibrous histiocytoma	30.0	SERPINA3, VIM, S100B, DES
5	extraskeletal myxoid chondrosarcoma	29.4	VIM, MUC1, S100A1, S100B, MAPT, EWSR1
6	myxoid chondrosarcoma	28.9	VIM, MUC1, MTAP, S100A1, S100B, CDKN2B
7	myoepithelioma	28.9	VIM, S100A1, S100B, T, EWSR1, TP53
8	pleomorphic adenoma	27.7	VIM, MUC1, S100A1, S100B, CDKN1B, AR
9	chordoid meningioma	27.5	NCAM1, VIM, VEGFA, LGALS3, MUC1, S100B
10	myasthenia gravis	26.3	NCAM1, LGALS1, MMP9, AR, HSP90B1, ESR2
11	mediastinitis	26.1	VIM, S100A1, CEACAM3, AKT1, TP53, PLAU
12	ependymoma	24.1	NCAM1, VIM, VEGFA, LGALS3, MUC1, S100B
13	tuberous sclerosis	24.0	VIM, VEGFA, S100B, CDKN1B, CDKN3, CCL26
14	malignant fibrous histiocytoma	23.5	SERPINA3, VIM, VEGFA, MUC1, S100A1, S100B
15	histiocytoma	22.9	SERPINA3, VIM, VEGFA, MUC1, S100A1, S100B
16	renal cell carcinoma	21.7	VIM, VEGFA, LGALS1, CHKA, MUC1, S100A1
17	chondrosarcoma	21.5	SERPINA3, VIM, VEGFA, VCAM1, LGALS1, MUC1
18	astrocytoma	16.5	NCAM1, SERPINA3, VIM, VEGFA, VCAM1, LGALS1
19	meningioma	16.4	NCAM1, SERPINA3, VIM, VEGFA, VCAM1, LGALS3
20	cervicitis	15.2	SERPINA3, VIM, VEGFA, VCAM1, LGALS1, LGALS3
21	gastric cancer	15.1	SERPINA3, VIM, VEGFA, VCAM1, LGALS1, LGALS3
22	adenoma	14.9	NCAM1, VIM, VEGFA, LGALS1, LGALS3, CHKA
23	sarcoma	14.5	NCAM1, SERPINA3, VIM, VEGFA, VCAM1, PAX7
24	thyroiditis	14.3	NCAM1, VIM, VEGFA, VCAM1, LGALS1, LGALS3
25	cutaneous leiomyosarcoma	14.0	VIM, MUC1, S100B, DES
26	spindle cell sarcoma	14.0	VIM, MUC1, S100B, KRT7, DES
27	cellular schwannoma	14.0	VIM, S100A1, S100B, GFAP
28	metanephric adenoma	14.0	VIM, MUC1, KRT7, DES
29	chordoid glioma	14.0	VIM, MUC1, S100B, KRT7, GFAP
30	ossifying fibromyxoid tumor	14.0	VIM, S100A1, S100B, DES
31	mesenchymal chondrosarcoma	14.0	VIM, MUC1, DES
32	congenital epulis	14.0	VIM, S100B, DES
33	fibrous meningioma	14.0	MUC1, S100B, DES
34	ovarian sex cord tumors	14.0	VIM, MUC1, CEACAM3, KRT7, DES
35	osteofibrous dysplasia	14.0	VIM, MUC1, KRT1, KRT19
36	adenomatoid tumor	14.0	VIM, MUC1, KRT7, KRT5, DES
37	mixed glioma	14.0	VIM, PDGFRA, GFAP
38	perineurioma	14.0	NCAM1, VIM, MUC1, S100B, PDGFRA, DES
39	sarcomatoid mesothelioma	14.0	VIM, MUC1, S100A1, CEACAM3, PDPN, DES
40	epidermolytic palmoplantar keratoderma	14.0	JUP, KRT1, KRT14
41	epulis	13.9	VIM, S100B, DES
42	mucinous cystadenocarcinoma	13.9	MUC1, CEACAM3, KRT7, KRT20
43	choroid plexus papilloma	13.9	MUC1, S100B, GFAP
44	hidradenitis	13.9	MUC1, KRT8, KRT1, KRT14
45	cutaneous fibrous histiocytoma	13.9	S100A1, S100B, PDGFB, DES
46	hidrocystoma	13.9	MFGE8, KRT8, KRT7, KRT19
47	ossifying fibroma	13.9	VIM, S100A1, KRT1, TSC1, DES
48	glomus tumor	13.9	VIM, MUC1, S100A1, S100B, CDKN2B, DES
49	langerhans-cell histiocytosis	13.9	S100A1, S100B, PDGFB
50	epithelial-myoepithelial carcinoma	13.9	VIM, KRT14, GFAP

Approved drugs:

Drug clinical trials:

Genetic tests related to chordoma:

id	Genetic test	Affiliating Genes
1	Chordoma clinical/research

MalaCards organs/tissues related to chordoma:

²²

MGI Mouse Phenotypes related to chordoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	SOX9, MYH11, PDGFB, TBX1, PAX7
2	craniofacial phenotype	MP:0005382	10.0	SOX9, TYRP1, KRT5, PDGFRB, PDGFRA, CTSK
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	EWSR1, TBX1, CTSK, CTNNA1, SOX9, CDH3
4	embryogenesis phenotype	MP:0005380	9.3	VIM, PAX7, UGDH, T, JUP, CDH2
5	pigmentation phenotype	MP:0001186	9.1	KRT14, KRT1, PDGFRA, PDGFB, PTEN, TP53
6	limbs/digits/tail phenotype	MP:0005371	8.9	CTSK, CTNNA1, PDGFRA, KRT5, SOX9, TBX1
7	renal/urinary system phenotype	MP:0005367	8.8	PDGFB, PDGFRA, PDGFRB, HIF1A, TSC1, MYH11
8	normal phenotype	MP:0002873	8.1	ESR2, TERT, TBX1, PDGFRA, HIF1A, GFAP
9	other phenotype	MP:0005395	8.0	ABCC1, ABCB1, PDGFRA, CTNNA1, CTSK, PTGS2
10	liver/biliary system phenotype	MP:0005370	7.7	VEGFA, CHKA, MTAP, MLXIPL, AR, MET
11	behavior/neurological phenotype	MP:0005386	7.7	TBX1, PDGFRA, PDPN, KRT5, ABCB1, GFAP
12	integument phenotype	MP:0010771	7.6	LGALS1, PDPN, KRT5, KRT1, KRT19, KRT14
13	immune system phenotype	MP:0005387	7.5	MTAP, JUP, CDKN2B, CDKN1B, MFGE8, MAPT
14	adipose tissue phenotype	MP:0005375	7.5	PTEN, PTGS2, PLAU, PDGFRB, TGFA, TP53
15	nervous system phenotype	MP:0003631	7.5	PAX7, LGALS1, LGALS3, T, JUP, CDH2
16	reproductive system phenotype	MP:0005389	7.3	PDGFB, PDGFRA, KRT8, KRT19, KRT14, TYRP1
17	no phenotypic analysis	MP:0003012	7.2	ESR2, TP53, PTGS2, TBX1, PKM, PDGFB
18	vision/eye phenotype	MP:0005391	6.0	PDGFB, PLAU, SMARCB1, PTGS2, PTEN, PDGFRB
19	skeleton phenotype	MP:0005390	5.5	VEGFA, PAX7, LGALS3, CDKN2A, MMP9, AR
20	muscle phenotype	MP:0005369	5.1	CDKN1B, CDKN2A, MMP9, AR, MET, MDM2
21	tumorigenesis	MP:0002006	4.8	MET, KRT14, HIF1A, TYRP1, TSC1, PGR
22	growth/size phenotype	MP:0005378	4.7	EWSR1, KRT19, HIF1A, GFAP, TYRP1, TSC1
23	cardiovascular system phenotype	MP:0005385	2.9	TBX1, HGF, MYH11, PGR, SOX9, DES
24	digestive/alimentary phenotype	MP:0005381	INF	VEGFA, PAX7, LGALS3, UGDH, MUC1, T
25	mortality/aging	MP:0010768	INF	NCAM1, CCND1, GPI, HSP90B1, EWSR1, ETS2
26	cellular phenotype	MP:0005384	INF	NCAM1, VIM, VEGFA, VCAM1, PAX7, LGALS3
27	hematopoietic system phenotype	MP:0005397	INF	SMARCB1, PDGFB, PDGFRA, KRT8, TG, TFRC
28	homeostasis/metabolism phenotype	MP:0005376	INF	VIM, VEGFA, VCAM1, LGALS3, CHKA, ETS2

Articles related to chordoma:

(show top 50)    (show all 92)

id	Title	Authors	Year	Affiliating Genes
1	Gain of chromosome 7 by chromogenic in situ hybridiza tion (CISH) in chordomas is correlated to c-MET expression. (20617367)	Walter B.A.... Quezado M.	2011	MET
2	Recurrent chromosomal copy number alterations in spor adic chordomas. (21602918)	Le L.P.... Iafrate A.J.	2011	PTEN, CDKN2A
3	Classic chordoma coexisting with benign notochordal c ell rest demonstrating different immunohistological expression patterns of brac hyury and galectin-3. (20855213)	Shen J.... Deng M.	2011	LGALS3, T
4	Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in sacral chordoma. (20549300)	Chen K.W.... Gu Y.P.	2011	MMP9, VEGFA
5	Methylthioadenosine phosphorylase and activated insul in-like growth factor-1 receptor/insulin receptor: potential therapeutic target s in chordoma. (20140939)	Sommer J.... Cates J.M.	2010	MTAP
6	Characterization and analysis of human chordoma cell lines. (20461036)	Yang C.... Duan Z.	2010	VIM
7	Revisiting chordoma with brachyury, a 'new age' marker: analysis of a validation study on 51 cases. (20670140)	Jambhekar N.A.... Puri A.	2010	T
8	MET overexpressing chordomas frequently exhibit polys omy of chromosome 7 but no MET activation through sarcoma-specific gene fusions . (20512480)	Grabellus F.... Schmid K.W.	2010	MET
9	Loss of SMARCB1/INI1 expression in poorly differentia ted chordomas. (21057957)	Mobley B.C.... Vogel H.	2010	SMARCB1
10	Immunohistochemical comparison of chordoma with chond rosarcoma, myxopapillary ependymoma, and chordoid meningioma. (19521276)	Cho H.Y.... Zhai Q.J.	2009	S100B, NCAM1, MUC1
11	Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma. (19302530)	Naka T.... Roessner A.	2009	MET
12	Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. (19276265)	Han S.... Ramesh V.	2009	AKT1, PTEN, CDKN3
13	Mandibular metastasis from a skull base chordoma: rep ort of a case with review of literature. (20190948)	Loehn B.... Nuss D.	2009	VIM, MUC1
14	Expression of hepatocyte growth factor and c-MET in skull base chordoma. (17948912)	Naka T.... Roessner A.	2008	MET
15	Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (18301055)	Tirabosco R.... Flanagan A.M.	2008	T
16	Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation. (18071362)	Hallor K.H.... Mertens F.	2008	CDKN2A, CDKN2B
17	New candidate chromosomal regions for chordoma development. (17714767)	Bayrakli F.... Pamir M.N.	2007	VEGFA, TGFA
18	Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation. (16810540)	O'Donnell P.... Flanagan A.M.	2007	MUC1, KRT19
19	Metastatic chordoma of the breast: an extremely rare lesion mimicking mucinous cancer. (17004976)	Tot T.	2006	S100B, KRT7
20	Cadherins and catenins in clival chordomas: correlation of expression with tumor aggressiveness. (16224208)	Triana A.... Hazan R.	2005	CDH2, JUP
21	Case report: familial gastric cancer and chordoma in the same family. (20223035)	Weber W.... Scott R.J.	2005	CDH1
22	Cervical chordoma masquerading as a thyroid neoplasm: a case report. (15830368)	Saqi A.... Baloch Z.	2005	TG
23	Chordomas: a histological and immunohistochemical study of cases with and without recurrent tumors. (15584212)	Sell M.... Theallier A.	2004	VIM, DES, MUC1
24	Parachordoma is not distinguishable from axial chordoma using immunohistochemistry. (15086843)	Scolyer R.A.... McCarthy S.W.	2004	MUC1, KRT7, CEACAM3
25	Chordoma of the skull base: predictors of tumor recurrence. (12691407)	Pallini R.... Larocca L.M.	2003	TP53, TERT
26	Galectin-3: a biologic marker and diagnostic aid for chordoma. (11953597)	Juliao S.F.... Schwartz H.S.	2002	LGALS3, LGALS1
27	Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (11452362)	Kelley M.J.... Parry D.M.	2001	CHDM
28	Ectopic chordoma with orbital invasion. (11239887)	Moshari A.... Buckwalter N.R.	2001	VIM, MUC1
29	Sarcomatoid chordoma: chordoma with a massive malignant spindle-cell component. (11271555)	Morimitsu Y.... Hashimoto H.	2000	VIM, MUC1
30	Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors. (10439798)	Hu B.... French S.W.	1999	MAPT
31	Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma. (9490269)	O'Hara B.J.... Miettinen M.	1998	KRT19
32	Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. (9195570)	Naka T.... Tsuneyoshi M.	1997	KRT18, KRT8, KRT19
33	Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma. (9447709)	Gotz W.... Hughes R.C.	1997	LGALS3, MLXIPL
34	Significance of immunohistochemical study in the diagnosis and differential diagnosis of chordoma (8697996)	Xu Y.... Ji P.	1995	GFAP
35	Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. (7532910)	Jeffrey P.B.... Davis R.L.	1995	MUC1, S100A1
36	Immunohistochemical and electron microscopic studies on intracranial chordomas: difference between typical chordomas and chondroid chordomas. (7512865)	Niwa J.... Minase T.	1994	VIM, MUC1
37	Immunohistochemical and ultrastructural study of skull base chordomas. (7512866)	Kubota T.... Yamashita J.	1994	VIM, DES, MUC1
38	Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? (7525890)	Ishida T.... Dorfman H.D.	1994	MUC1
39	Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. (8091802)	Choi Y.J.... Kim T.S.	1994	VIM, MUC1, SERPINA3
40	Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. (7506477)	Rosenberg A.E.... Lee J.M.	1994	VIM, MUC1, CEACAM3
41	Microtubule aggregates in a clival chordoma. (8215832)	Jeffrey P.B.... Rosenblum M.	1993	S100A1
42	Myasthenia gravis in a man with a history of chordoma: observations of muscle-like antigens in carcinoma. (8454279)	Carson H.J.... Streib E.W.	1993	DES
43	Chordoma and chondroid neoplasms of the spheno-occiput. An immunohistochemical study of 41 cases with prognostic and nosologic implications. (7693324)	Mitchell A.... McGivney D.J.	1993	S100B
44	Expression of intermediate filaments in chordomas. An immunocytochemical study of five cases. (1280357)	Maiorano E.... Ricco R.	1992	VIM, DES, GFAP
45	Sarcomatous transformation in cranial chordoma. (1641093)	Tomlinson F.H.... Meyer F.B.	1992	MUC1
46	Value of immunocytochemistry in aspiration cytology of sacrococcygeal chordoma. A report of two cases. (1546518)	Plate K.H.... Bittinger A.	1992	VIM, MUC1
47	Coexpression of intermediate filaments in notochords and chordomas and its significance in the histogenesis and diagnosis of chordoma (1283974)	Fang X.Z.	1992	VIM, DES, GFAP
48	Chordoma-natural history, treatment and prognosis. The Florence Radiotherapy Department experience (1956-1990) and a critical review of the literature. (1290633)	Magrini S.M.... Biti G.	1992	GTPBP3
49	Chordomas with malignant spindle cell components. A DNA flow cytometric and immunohistochemical study with histogenetic implications. (1696786)	Hruban R.H.... Huvos A.G.	1990	S100B, VIM, MUC1
50	Expression of embryonal and differentiational proteins in chordomas and in the notochord (1688959)	Tamayama C.... Maruyama K.	1990	S100B

Genes related to chordoma according to GeneCards:

(show top 50)    (show all 85)

id	Symbol	Description	Score	GeneCards Section Context
1	CHDM	Chordoma	11.0	Publications, Aliases & Descriptions
2	S100A1	S100 calcium binding protein A1	11.0	Publications
3	VIM	vimentin	11.0	Publications
4	MUC1	mucin 1, cell surface associated	11.0	Publications
5	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
6	S100B	S100 calcium binding protein B	11.0	Publications
7	KRT1	keratin 1	11.0	Publications
8	DES	desmin	11.0	Publications
9	KRT7	keratin 7	11.0	Publications
10	KRT19	keratin 19	11.0	Publications
11	GFAP	glial fibrillary acidic protein	11.0	Publications
12	JUP	junction plakoglobin	11.0	Publications
13	KRT18	keratin 18	11.0	Publications
14	KRT14	keratin 14	11.0	Publications
15	KRT5	keratin 5	11.0	Publications
16	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
17	KRT8	keratin 8	11.0	Publications
18	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
19	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	11.0	Publications
20	NCAM1	neural cell adhesion molecule 1	11.0	Publications
21	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
22	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
23	LOH1CR1	loss of heterozygosity, 1, chromosomal region 1	11.0	Publications
24	T	T, brachyury homolog (mouse)	11.0	Publications
25	GTPBP3	GTP binding protein 3 (mitochondrial)	11.0	Publications
26	MMP19	matrix metallopeptidase 19	11.0	Publications
27	TYRP1	tyrosinase-related protein 1	11.0	Publications
28	TBX1	T-box 1	11.0	Publications
29	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
30	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
31	UGDH	UDP-glucose 6-dehydrogenase	11.0	Publications
32	ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	11.0	Publications
33	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0	Publications
34	MTAP	methylthioadenosine phosphorylase	11.0	Publications
35	PDPN	podoplanin	11.0	Publications
36	MFGE8	milk fat globule-EGF factor 8 protein	11.0
37	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
38	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
39	MLXIPL	MLX interacting protein-like	11.0	Publications
40	ENO1	enolase 1, (alpha)	11.0	Publications
41	GPI	glucose-6-phosphate isomerase	11.0	Publications
42	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
43	CTSK	cathepsin K	11.0	Publications
44	HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	11.0	Publications
45	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
46	PAX7	paired box 7	11.0	Publications
47	KRT20	keratin 20	11.0	Publications
48	LGALS1	lectin, galactoside-binding, soluble, 1	11.0	Publications
49	CHKA	choline kinase alpha	11.0	Publications
50	TSC1	tuberous sclerosis 1	11.0	Publications

Pathways related to chordoma according to GeneDecks:

(show top 50)    (show all 91)

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Keratin filaments10	10.7	VIM, KRT1, KRT7, KRT18, KRT19, KRT14
2	Cytoskeleton remodeling_Keratin filaments41	10.7	KRT8, KRT7, KRT14, KRT5, KRT1, KRT18
3	Cell adhesion_Cadherin-mediated cell adhesion41	10.4	CDH2, CDH1, CTNNA1, MET, CDH3, JUP
4	Cell adhesion Cadherin-mediated cell adhesion10	10.4	JUP, CDH2, CDH1, MET, CTNNA1, CDH3
5	Adhesion3	10.3	CDH3, CDH2, NCAM1, CTNNA1, JUP, ICAM1
6	PPAR Pathway36	10.2	NUDT6, PDGFRB, PDGFRA, PDGFB, AKT1, MET
7	S-1P Stimulated Signaling36	10.2	CDH2, CDH3, CDH1, AKT1, PDGFRA, PDGFB
8	14-3-3 Induced Intracellular Signaling36	10.1	NUDT6, TSC1, PDGFRB, PDGFB, AKT1, MAPT
9	Breast Cancer Regulation by Stathmin136	9.9	NUDT6, TGFA, PDGFB, HGF, FGFR4
10	Renal cell carcinoma20	9.9	HGF, PDGFB, MET, HIF1A, TGFA
11	Development_HGF signaling pathway41	9.8	CDH1, MET, AKT1, PLAU, HGF
12	JNK Pathway36	9.8	NUDT6, PDGFRB, PDGFB, FGFR4, TP53, PDGFRA
13	Cell adhesion Cell-matrix glycoconjugates10	9.8	MMP1, MUC1, LGALS3, NCAM1, MMP9
14	ERK5 Signaling36	9.7	TGFA, PDGFRB, PDGFRA, HGF, AKT1, FGFR4
15	Cell adhesion_Cell-matrix glycoconjugates41	9.7	NCAM1, MMP9, LGALS3, MMP1
16	eIF2 Pathway36	9.6	NUDT6, FGFR4, PDGFB, PDGFRA, PDGFRB, TGFA
17	DHA Signaling36	9.6	AKT1, PDGFRA, PDGFB, TGFA, NUDT6, HGF
18	PAK Pathway36	9.6	PDGFRA, FGFR4, MET, TGFA, NUDT6, HGF
19	Rho Family GTPases36	9.6	FGFR4, MET, CDH1, CDH3, CCL26, CDH2
20	p70S6K Signaling36	9.6	MET, PDGFB, PDGFRA, PDGFRB, NUDT6, HGF
21	eNOS Signaling36	9.5	HGF, NUDT6, TGFA, PDGFRB, PDGFRA, PDGFB
22	GSK3 Signaling36	9.5	CDH3, CDH1, FGFR4, MET, AKT1, PDGFRA
23	Glioblastoma Multiforme36	9.5	PTEN, PDGFB, CDKN1B, MDM2, TP53, AKT1
24	TGF-Beta Pathway36	9.4	NUDT6, CDH1, FGFR4, MET, CCL26, AKT1
25	Epithelial Adherens Junctions36	9.4	CTNNA1, NUDT6, HGF, MYH11, JUP, CDH1
26	PTEN Pathway36	9.3	PDGFRB, NUDT6, MET, MDM2, HGF, PDGFRA
27	Apoptotic Pathways in Synovial Fibroblasts36	9.3	NUDT6, HGF, MET, FGFR4, AKT1, TP53
28	Angiogenesis3	9.2	PTGS2, PDGFRA, FGFR4, MMP9, PDGFRB, HIF1A
29	Endometrial cancer20	9.2	TP53, CDH1, CCND1, PTEN, AKT1, CTNNA1
30	Estrogen Pathway36	9.1	PDGFRA, PDGFRB, PDGFB, ESR2, CCND1, TGFA
31	Renin-Angiotensin Pathway36	9.1	HGF, VCAM1, MET, NUDT6, TGFA, PDGFRB
32	G1-S Phase Transition36	9.1	CCND1, CDKN2A, CDKN1B, CDKN2B, TP53
33	Telomerase Components in Cell Signaling36	9.1	MET, TP53, PDGFB, HGF, NUDT6, TGFA
34	Focal adhesion20	9.0	PTEN, AKT1, CCND1, VEGFA, PDGFB, PDGFRA
35	Signal transduction_AKT signaling41	9.0	CDKN1B, MDM2, CCND1, HSP90B1, AKT1, TP53
36	p53 Mediated Apoptosis36	9.0	PDGFRA, NUDT6, HGF, PDGFB, TP53, TGFA
37	Mitochondrial Apoptosis36	9.0	HGF, FGFR4, PDGFRB, CDKN2A, PDGFRA, TGFA
38	Cellular Apoptosis Pathway36	9.0	MDM2, MET, FGFR4, AKT1, PDGFRB, NUDT6
39	Glioma20	8.9	AKT1, CDKN2A, CCND1, TP53, PDGFB, PDGFRA
40	Chronic myeloid leukemia20	8.9	TP53, AKT1, CCND1, MDM2, CDKN2A, CDKN1B
41	ILK Signaling36	8.8	MYH11, NUDT6, TGFA, HIF1A, KRT18, PDGFRA
42	Prostate cancer20	8.7	CCND1, MDM2, AR, CDKN1B, PDGFRB, PDGFRA
43	Melanoma20	8.6	HGF, PDGFRB, PDGFRA, PTEN, AKT1, CCND1
44	Small cell lung cancer20	8.6	TP53, AKT1, CCND1, PTGS2, CDKN1B, CDKN2B
45	Bladder cancer20	8.4	TP53, MDM2, MMP9, CCND1, VEGFA, CDH1
46	Pancreatic Adenocarcinoma36	7.0	CDKN2B, CDKN1B, CDKN2A, MMP1, MMP19, MMP9
47	Pathways in cancer20	6.7	CCND1, MDM2, MET, AR, MMP9, MMP1
48	Molecular Mechanisms of Cancer36	INF	CDKN2B, CDH1, CCND1, CDKN1B, CDKN2A, NUDT6
49	Antioxidant Action of Vitamin-C36	INF	PDGFRA, MYH11, , CCL26, MET, FGFR4
50	Akt Signaling36	INF	PDGFRB, MET, CCL26, HGF, AKT1,

Compounds related to chordoma according to GeneDecks:

(show top 50)    (show all 290)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.7	PDGFRB, KRT18
2	mucicarmine32	10.6	VIM, MUC1, S100A1, S100B, CEACAM3, KRT7
3	b 72332	10.2	VIM, CHKA, MUC1, S100A1, S100B, CEACAM3
4	hyaluronic acid32 18	10.7	VIM, UGDH, MUC1, CDH1, MMP1, PTEN
5	h2o232	9.6	LGALS3, CDKN3, MAPT, ICAM1, ESR2, PDGFRB
6	rapamycin32 42	10.4	VIM, VEGFA, LGALS1, AR, MET, MDM2
7	glucose32	9.3	LGALS1, UGDH, S100B, MKI67, ENO1, GPI
8	bromodeoxyuridine32	9.0	NCAM1, VIM, S100B, CDKN1B, MKI67, CCND1
9	arginine32	8.6	SERPINA3, LGALS1, S100B, AR, FGFR4, MDM2
10	estradiol32 9 18 9	11.4	SERPINA3, VIM, CHKA, MUC1, CDKN1B, MKI67
11	aspartate32	8.3	VIM, S100B, CEACAM3, CDKN2A, CDH1, MMP9
12	tgf beta132	8.3	VCAM1, CDKN2B, CDKN1B, CDH1, MMP1, MKI67
13	hematoxylin32	8.3	NCAM1, VIM, LGALS3, CHKA, MUC1, S100A1
14	lipid32	8.3	NCAM1, SERPINA3, VIM, VCAM1, LGALS1, LGALS3
15	polysaccharide32	8.2	NCAM1, SERPINA3, VCAM1, LGALS1, LGALS3, UGDH
16	proline32	7.9	VIM, LGALS3, S100B, CDH1, MMP9, MKI67
17	ly29400232	7.9	VEGFA, CDKN1B, CDKN3, CDH1, MMP9, CCND1
18	glycogen32 18	8.9	VIM, LGALS3, CHKA, S100A1, S100B, CDH2
19	progesterone32 42 9 18 9	11.8	NCAM1, SERPINA3, CHKA, S100A1, S100B, CEACAM3
20	5-aza-2deoxycytidine32	7.8	VIM, JUP, CDH2, CDKN2B, CDKN2A, CDH1
21	creatinine32	7.7	NCAM1, SERPINA3, VIM, CHKA, MUC1, S100B
22	glutamate32	7.7	NCAM1, VIM, LGALS3, CHKA, UGDH, CDH2
23	estrogen32	7.7	SERPINA3, LGALS3, CHKA, S100A1, S100B, CEACAM3
24	calcium32 9 18 9	10.5	SERPINA3, LGALS1, LGALS3, CHKA, MUC1, S100A1
25	retinoid32	7.4	VIM, LGALS1, CDH1, MMP1, AR, CCND1
26	oxygen32 18	8.4	SERPINA3, LGALS1, LGALS3, CHKA, CEACAM3, CDKN1B
27	glutamine32	7.3	NCAM1, VIM, LGALS1, LGALS3, S100B, CDKN1B
28	atp32	7.3	NCAM1, LGALS3, CHKA, MTAP, CDH2, CDKN1B
29	thymidine32 18	8.1	CHKA, MUC1, MTAP, S100B, CEACAM3, CDKN1B
30	butyrate32	7.0	VIM, LGALS1, LGALS3, MUC1, CDKN1B, CDKN2A
31	cysteine32	6.8	SERPINA3, LGALS1, LGALS3, MUC1, S100A1, S100B
32	phosphatidylinositol32	6.7	NCAM1, VCAM1, LGALS3, CHKA, CDKN1B, CDKN3
33	etoposide32 42 9 9	9.7	LGALS1, LGALS3, S100B, CDKN1B, CDKN3, CDH1
34	methotrexate32 34 42 9 9	10.7	SERPINA3, VIM, MUC1, MTAP, CEACAM3, CDKN2B
35	matrigel32	6.6	NCAM1, VIM, VEGFA, VCAM1, LGALS1, LGALS3
36	lactate32	6.4	NCAM1, VIM, VCAM1, LGALS3, CHKA, S100B
37	gefitinib32 34 9 9	9.4	VIM, VEGFA, CDKN1B, CDKN3, CDH1, MMP9
38	5fluorouracil32	6.4	VEGFA, MUC1, CEACAM3, CDKN1B, CDKN2A, CDH1
39	alanine32	6.1	NCAM1, SERPINA3, VIM, VCAM1, LGALS3, CHKA
40	arsenite32 18	6.7	VEGFA, CDKN2B, CDKN2A, CDKN3, MMP1, MMP9
41	curcumin32	5.5	VEGFA, VCAM1, CDH1, MMP1, MMP9, AR
42	retinoic acid32 42 18	7.5	NCAM1, VCAM1, LGALS3, CHKA, S100B, JUP
43	paclitaxel32 34 9 9	7.9	VIM, VEGFA, S100B, JUP, CDKN1B, CDKN2A
44	dexamethasone32 42 34 9 9	8.9	NCAM1, SERPINA3, VIM, VEGFA, VCAM1, LGALS1
45	actinomycin d32	4.8	VIM, VEGFA, MUC1, CDKN1B, CDKN2A, CDKN3
46	testosterone32 9 18 9	7.4	NCAM1, VIM, VCAM1, CHKA, MUC1, S100B
47	doxorubicin32 34 9 9	7.3	NCAM1, VIM, VEGFA, CHKA, CEACAM3, CDKN1B
48	vegf32	4.1	NCAM1, VCAM1, LGALS3, MUC1, S100B, CEACAM3
49	tyrosine32	3.8	NCAM1, VEGFA, VCAM1, LGALS1, LGALS3, CHKA
50	genistein32 9 18 9	6.2	VIM, VEGFA, VCAM1, CHKA, CDH2, CDKN1B

Cellular components related to chordoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.4	VIM, DES, GFAP, KRT14, KRT19, KRT20
2	catenin complex	GO:016342	10.3	CTNNA1, CDH1, CDH2, JUP
3	keratin filament	GO:045095	10.3	KRT14, KRT18, KRT1, KRT5, KRT7, KRT8
4	cell-cell adherens junction	GO:005913	10.2	JUP, CDH2, CDH3, CDH1
5	protein complex	GO:043234	8.4	SOX9, TSC1, PTGS2, TP53, MDM2, AR
6	cell surface	GO:009986	8.3	TGFA, ABCB1, PDGFB, PLAU, CDH1, LGALS1
7	extracellular space	GO:005615	7.9	HGF, TGFA, PLAU, CTSK, ICAM1, GPI
8	nucleoplasm	GO:005654	7.1	TP53, TERT, SMARCB1, KRT8, HIF1A, PGR
9	cytosol	GO:005829	6.8	PKM, CTNNA1, PTEN, TP53, AKT1, KRT5
10	cytoplasm	GO:005737	4.9	PDGFRA, PDGFB, PKM, PTGS2, PTEN, TERT
11	nucleus	GO:005634	INF	PKM, SMARCB1, TBX1, PTGS2, PTEN, TP53
12	plasma membrane	GO:005886	INF	PKM, PLAU, CTNNA1, PTEN, , AKT1

Biological processes related to chordoma according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to indole-3-methanol	GO:071681	10.5	JUP, CDH1, CTNNA1
2	intermediate filament organization	GO:045109	10.5	GFAP, KRT20, VIM
3	adherens junction organization	GO:034332	10.5	JUP, CDH2, CDH3, CDH1, CTNNA1
4	cell junction assembly	GO:034329	10.4	KRT14, KRT5, CTNNA1, CDH1, CDH3, CDH2
5	retina vasculature development in camera-type eye	GO:061298	10.4	HIF1A, PDGFRB, PDGFRA
6	positive regulation of mitosis	GO:045840	10.4	TGFA, PDGFRB, PDGFB, MET
7	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.4	PDGFRB, PDGFRA, VEGFA
8	cell-cell junction organization	GO:045216	10.3	CTNNA1, CDH1, CDH3, CDH2, JUP
9	positive regulation of DNA biosynthetic process	GO:2000573	10.3	HGF, PDGFRB, PDGFB, FGFR4
10	negative regulation of cell size	GO:045792	10.3	TSC1, PTEN, AKT1
11	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.3	HGF, SOX9, PDGFRB, PDGFRA, PDGFB
12	cellular response to glucose stimulus	GO:071333	10.2	VCAM1, LGALS1, MET, ICAM1
13	negative regulation of epithelial cell proliferation	GO:050680	10.2	SOX9, PTEN, ESR2, AR, CDKN2B
14	cell chemotaxis	GO:060326	10.2	HGF, ABCC1, PDGFRB, PDGFRA, PDGFB
15	phosphatidylinositol-mediated signaling	GO:048015	10.1	PDGFRB, PDGFRA, PTEN, AKT1, MDM2, CDKN1B
16	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.0	JUP, AKT1, ESR2, PTEN, SMARCB1
17	positive regulation of cell migration	GO:030335	9.9	ABCC1, PDPN, PDGFRB, PDGFRA, PDGFB, CCL26
18	cellular response to interleukin-1	GO:071347	9.7	MMP9, ICAM1, HIF1A, SOX9
19	epidermal growth factor receptor signaling pathway	GO:007173	9.7	SOX9, TGFA, PTEN, AKT1, MDM2, CDKN1B
20	G1 phase of mitotic cell cycle	GO:000080	9.6	CCND1, CDKN2A, CDKN1B, CDKN2B
21	anti-apoptosis	GO:006916	9.6	HGF, TGFA, TERT, AKT1, HSP90B1, MUC1
22	angiogenesis	GO:001525	9.6	TGFA, HIF1A, TBX1, PTEN, GPI, MFGE8
23	replicative senescence	GO:090399	9.5	CDKN2A, TP53, TERT
24	cell cycle arrest	GO:007050	9.4	TSC1, TP53, CDKN3, CDKN2A, CDKN1B, CDKN2B
25	positive regulation of protein phosphorylation	GO:001934	9.3	SOX9, TBX1, AKT1, CCND1, VEGFA
26	positive regulation of cell proliferation	GO:008284	9.3	PTEN, TBX1, PDGFB, PDGFRA, PDGFRB, SOX9
27	response to organic cyclic compound	GO:014070	9.2	PDGFB, CTNNA1, PTGS2, ICAM1, CCND1, MET
28	cell proliferation	GO:008283	9.2	TGFA, PDPN, TBX1, PTEN, TP53, AKT1
29	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	PDGFRB, PDGFB, PTGS2, HIF1A
30	positive regulation of transcription, DNA-dependent	GO:045893	9.0	SOX9, HIF1A, PDGFB, TBX1, TP53, ETS2
31	negative regulation of apoptotic process	GO:043066	8.9	SOX9, KRT18, CTNNA1, PTEN, TP53, AKT1
32	signal transduction	GO:007165	8.7	PDGFRB, PDPN, HIF1A, TG, SOX9, PGR
33	cellular response to hypoxia	GO:071456	8.6	HIF1A, PTGS2, TP53, ICAM1, MDM2, VEGFA
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	SOX9, HIF1A, SMARCB1, TBX1, TP53, AKT1
35	response to drug	GO:042493	7.5	TGFA, ABCC1, ABCB1, PDGFB, PTGS2, ICAM1
36	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	HGF, PDGFB, , TP53, VEGFA
37	virus-host interaction	GO:019048	INF	VIM, TFRC, KRT19, KRT18, KRT7, KRT8

Molecular functions related to chordoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	HGF, KRT5, KRT7, KRT8, PDGFRB, PDGFRA
2	structural constituent of cytoskeleton	GO:005200	10.3	DES, GFAP, KRT14, KRT19, KRT20, KRT1
3	platelet-derived growth factor binding	GO:048407	10.3	PDGFRB, PDGFRA, PDGFB
4	gamma-catenin binding	GO:045295	10.2	CDH2, CDH1, CTNNA1
5	protein phosphatase binding	GO:019903	10.1	HSP90B1, CDH1, CDKN1B, CDH2, JUP
6	beta-catenin binding	GO:008013	10.1	SOX9, CTNNA1, MET, AR, CDH1, CDH2
7	platelet-derived growth factor receptor binding	GO:005161	10.1	PDGFRB, PDGFRA, PDGFB, VEGFA
8	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.0	CDKN2A, CDKN1B, CDKN2B
9	protein homodimerization activity	GO:042803	8.8	PTGS2, TBX1, PDGFB, PDGFRA, TYRP1, TERT
10	protein kinase binding	GO:019901	8.7	HIF1A, PTEN, TP53, CCND1, MAPT, CDKN2A
11	protein heterodimerization activity	GO:046982	8.7	HGF, TYRP1, HIF1A, PDGFB, TP53, MET
12	sequence-specific DNA binding transcription factor activity	GO:003700	8.0	PGR, SOX9, HIF1A, TBX1, TP53, ESR2
13	enzyme binding	GO:019899	7.5	PGR, HIF1A, PTGS2, PTEN, TP53, ESR2