MCID: CHR104
MIFTS: 42

Chorea malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Chorea

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NINDS:43 Chorea is an abnormal involuntary movement disorder, one of a group of neurological disorders called which are caused by overactivity of the neurotransmitter dopamine in the areas of the brain that control movement. Chorea is characterized by brief, irregular contractions that are not repetitive or rhythmic, but appear to flow from one muscle to the next. Chorea often occurs with which adds twisting and writhing movements. Chorea is a primary feature of a progressive, hereditary movement disorder that appears in adults, but it may also occur in a variety of other conditions. occurs in a small percentage (20 percent) of children and adolescents as a complication of rheumatic fever. Chorea can also be induced by drugs (levodopa, anti-convulsants, and anti-psychotics) metabolic and endocrine disorders, and vascular incidents.

MalaCards based summary: Chorea is related to chorea-acanthocytosis and huntington's disease. An important gene associated with Chorea is VPS13A (vacuolar protein sorting 13 homolog A (S. cerevisiae)), and among its related pathways is Neuroscience. The compound sodium have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and globus pallidus, and related mouse phenotypes are mortality/aging and nervous system.

Wikipedia:65 Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of... more...

Aliases & Classifications for Chorea

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Chorea, Aliases & Descriptions:

Name: Chorea 43 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Chorea

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Graphical network of the top 20 diseases related to Chorea:



Diseases related to chorea

Symptoms for Chorea

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Drugs & Therapeutics for Chorea

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Drug clinical trials:

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Genetic Tests for Chorea

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Anatomical Context for Chorea

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MalaCards organs/tissues related to Chorea:

32
Brain, Thyroid, Globus pallidus, Temporal lobe, Eye, Cortex, Lung, Thalamus, Caudate nucleus, Pituitary, Heart, Skeletal muscle, Breast, Testes, Monocytes, Tongue, Adrenal cortex

Animal Models for Chorea or affiliated genes

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MGI Mouse Phenotypes related to Chorea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7PAX9, TOR1A, CACNA1B, NKX2-1, OPA3
2MP:00036317.7OPA3, NKX2-1, CACNA1B, TOR1A, VPS13A
3MP:00053867.2TOR1A, VPS13A, CACNA1B, NKX2-1, OPA3, PAX9

Publications for Chorea

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Articles related to Chorea:

(show top 50)    (show all 803)
idTitleAuthorsYear
1
Chorea-ballism associated with ketotic hyperglycemia. (25262066)
2014
2
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
3
Huntington's disease gene expansion associates with early onset nonprogressive chorea. (23536475)
2013
4
Gowers' Queen Square case notes on chorea: a 21st century re-appraisal. (23128056)
2013
5
Paraneoplastic chorea caused by anti-CRMP5 antibodies associated with small cell lung cancer. (23582747)
2013
6
Acute-onset chorea, dystonia, and cardiac fibroelastoma in a child: a paraneoplastic association? (23238994)
2013
7
Delayed chorea after recovery from a symmetric parkinsonian syndrome due to striatal myelinolysis. (22682647)
2012
8
Beneficial Effects of Fluvoxamine for Chorea in a Patient With Huntington's Disease: A Case Report. (23585991)
2012
9
Post pump chorea in a 77-year-old male. (21499730)
2011
10
Further Evidence for Celiac Disease-associated Chorea. (23439937)
2011
11
Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea. (21559940)
2011
12
Hyperthyroid chorea. (21496587)
2011
13
Serum levels of brain-derived neurotrophic factor in Sydenham's chorea. (20112124)
2010
14
The prevalence of neuropsychiatric disorders in Sydenham's chorea. (20304326)
2010
15
Re: Chorea-acanthocytosis: report of two Brazilian cases. (19373931)
2009
16
Cardiac papillary fibroelastoma presenting as chorea in childhood. (19458993)
2009
17
Polycythemia and chorea. (19139620)
2009
18
Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea. (17965987)
2009
19
Chorea induced by a luteinizing hormone-releasing hormone analog. (18500493)
2008
20
Acute chorea and bilateral basal ganglia lesions in a hemodialysis patient. (18185507)
2008
21
Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. (17513792)
2007
22
Atypical onset of symptoms in Huntington disease: severe cognitive decline preceding chorea or other motor manifestations. (17159620)
2006
23
The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea. (16221531)
2006
24
A case of late-onset chorea. (16932507)
2005
25
Nemaline rods in chorea-acanthocytosis. (15660376)
2005
26
Two cases of hyperglycemic chorea in diabetic patients. (14984460)
2004
27
Diagnostic role of 99mTc hexamethyl-propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea. (15310312)
2004
28
Chorea as a presenting feature of variant Creutzfeldt-Jakob disease. (12815669)
2003
29
CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? (12620654)
2003
30
Sydenham's chorea in the age of MRI: a case report and review. (12160978)
2002
31
A case of chorea-acanthocytosis with dilated cardiomyopathy and myopathy]. (11218703)
2000
32
Anti-nuclear antibodies in Sydenham's chorea. (9331621)
1997
33
Senile chorea: a multicenter prospective study. (9088388)
1997
34
Sydenham's chorea and schizophrenia: a case report. (7547648)
1995
35
Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis]. (7669403)
1995
36
Loss of striatal histamine H2 receptors in Huntington's chorea but not in Parkinson's disease: comparison with animal models. (7904088)
1993
37
Neuropsychiatric aspects of Sydenham's chorea: a case report. (8358529)
1993
38
Reversible striatal hypermetabolism in a case of Sydenham's chorea. (8341301)
1993
39
Sydenham's chorea: physical and psychological symptoms of St Vitus dance. (8464654)
1993
40
Sydenham's chorea. (2075007)
1990
41
Chorea-acanthocytosis: a report of three new families and implications for genetic counselling. (3322006)
1987
42
Chorea gravidarum in systemic lupus erythematosus. (4087276)
1985
43
Chorea gravidarum and SLE. (6503770)
1984
44
Sodium valproate and baclofen for Sydenham's chorea. (6407124)
1983
45
Morphological abnormalities of erythrocyte membrane in the hereditary neurological disease with chorea, areflexia and acanthocytosis. (6216328)
1982
46
Psychological correlates of the course of Sydenham's chorea. Repeat evaluations of a case. (1165335)
1975
47
A comparative study of the treatment of chorea minor. (13555638)
1958
48
Sydenham's chorea. II. Effects of hormone therapy. (14360739)
1955
49
Chorea gravidarum; review of the recent literature and report of five cases. (18864038)
1948
50
The Etiology of Sydenham's Chorea: Electroencephalographic Studies. (20322055)
1941

Variations for Chorea

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Expression for genes affiliated with Chorea

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Expression patterns in normal tissues for genes affiliated with Chorea

Search GEO for disease gene expression data for Chorea.

Pathways for genes affiliated with Chorea

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Pathways related to Chorea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NKX2-1, TOR1A

Compounds for genes affiliated with Chorea

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Sources:
44Novoseek, 24HMDB
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Compounds related to Chorea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium44 2410.1NKX2-1, CACNA1B, XK

GO Terms for genes affiliated with Chorea

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Biological processes related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:0074929.5NKX2-1, PAX9
2locomotory behaviorGO:0076268.9NKX2-1, CACNA1B, VPS13A

Molecular functions related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3NKX2-1, CACNA1B, XK, TOR1A, PAX9, VPS13A

Products for genes affiliated with Chorea

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  • Antibodies
  • Proteins
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Sources for Chorea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet