MCID: CHR104
MIFTS: 32

Chorea malady

Summaries for Chorea

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Chorea is an abnormal involuntary movement disorder, one of a group of neurological disorders called which are caused by overactivity of the neurotransmitter dopamine in the areas of the brain that control movement. Chorea is characterized by brief, irregular contractions that are not repetitive or rhythmic, but appear to flow from one muscle to the next. Chorea often occurs with which adds twisting and writhing movements. Chorea is a primary feature of a progressive, hereditary movement disorder that appears in adults, but it may also occur in a variety of other conditions. occurs in a small percentage (20 percent) of children and adolescents as a complication of rheumatic fever. Chorea can also be induced by drugs (levodopa, anti-convulsants, and anti-psychotics) metabolic and endocrine disorders, and vascular incidents.

MalaCards: Chorea is related to chorea-acanthocytosis and huntington's disease. An important gene associated with Chorea is VPS13A (vacuolar protein sorting 13 homolog A (S. cerevisiae)), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Alpha-synuclein signaling. The compounds it 15 and cystamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are growth/size and behavior/neurological.

Wikipedia:63 Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of... more...

Aliases & Classifications for Chorea

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43NINDS, 60UMLS
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Aliases & Descriptions:

chorea 43 60


Related Diseases for Chorea

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17GeneCards, 18GeneDecks
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Diseases in the Chorea family:

Chorea Familial Benign

Diseases related to Chorea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1chorea-acanthocytosis31.2VPS13A, XK, JPH3
2huntington's disease31.0VPS13A, JPH3, HTT, TGM2
3neuroacanthocytosis30.5XK
4dementia30.4HTT, TH, CXCL10
5parkinson's disease30.3TGM2, HTT, TOR1A, TH
6graves' disease30.1CXCL10, PAX8, NKX2-1
7schizophrenia30.0TH, RHD
8lung cancer29.9NKX2-1
9hypothyroidism29.9NKX2-1, PAX8
10herpes simplex29.9TH, CXCL10
11pantothenate kinase-associated neurodegeneration29.9JPH3
12dentatorubral-pallidoluysian atrophy29.9HTT, JPH3
13myoclonus-dystonia29.7TOR1A, SGCE
14sjogren's syndrome29.7CXCL9
15leukemia29.7LYN, RHD
16movement disease29.7TH, TOR1A, SGCE
17goiter29.7PAX8, NKX2-1
18chorea gravidarum10.6
19neuronitis10.4
20lupus erythematosus10.4
21chorea minor10.4
22sydenham's chorea10.4
23rheumatic fever10.3
24cerebritis10.3
25systemic lupus erythematosus10.3
26benign hereditary chorea10.3
27moyamoya disease10.3
28diabetes mellitus10.2
29encephalitis10.2
30mcleod syndrome10.2
31antiphospholipid syndrome10.2
32diabetic ketoacidosis10.1
33hydrocephalus10.1
34polycythemia10.1
35thyroiditis10.1
36obsessive-compulsive disorder10.1
37hyperglycemia10.1
38hyperthyroidism10.1
39motor neuron disease10.1
40neurologic diseases10.1
41levine-critchley syndrome10.1
42polycythemia vera10.0
43temporal lobe epilepsy10.0
44alzheimer's disease10.0
45type 1 diabetes mellitus10.0
46cerebellar ataxia10.0
47dilated cardiomyopathy10.0
48methylmalonic acidemia10.0
49neuropathy10.0
50retinitis10.0

Graphical network of the top 20 diseases related to Chorea:



Diseases related to chorea

Clinical Features for Chorea

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Drugs & Therapeutics for Chorea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Chorea

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Anatomical Context for Chorea

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32MalaCards
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MalaCards organs/tissues related to Chorea:

32
Brain

Animal Models for Chorea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chorea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053789.8SLC4A1, TH, NKX2-1, JPH3, OPA3, HTT
2MP:00053869.7TGM2, SGCE, TH, NKX2-1, PAX9, TOR1A
3MP:00053859.7TGM2, HTT, PAX8, SGCE, SLC4A1, CACNA1B
4MP:00036319.5JPH3, TGM2, LYN, PAX8, SGCE, TH
5MP:00053769.4TGM2, LYN, PAX8, SLC4A1, TH, CXCL10
6MP:00107689.3CACNA1B, CXCL10, GEMIN2, NKX2-1, TOR1A, JPH3
7MP:00053849.3CXCL10, LYN, PAX8, SGCE, SLC4A1, TH

Publications for Chorea

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Genetic Variations for Chorea

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Expression for genes affiliated with Chorea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chorea

Search GEO for disease gene expression data for Chorea.

Pathways for genes affiliated with Chorea

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49PharmGKB, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
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Pathways related to Chorea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TH, CACNA1B
210.2TOR1A, TH, LYN
310.2TOR1A, TH, NKX2-1, HTT
4
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10.1LYN, CACNA1B, CXCL10, CXCL9

Compounds for genes affiliated with Chorea

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Chorea according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1it 154410.6JPH3, HTT
2cystamine4410.6TGM2, HTT
33-nitropropionic acid4410.6TH, HTT
4naoh4410.6RHD, SLC4A1
5sodium iodide4410.5NKX2-1, PAX8
6glucose4410.4SLC4A1, RHD, HTT
7forskolin44 49 1112.4HTT, NKX2-1, CXCL10, TH, PAX8
8sodium44 2411.4XK, CACNA1B, NKX2-1, SLC4A1, PAX8
9oxalate4410.4SLC4A1, RHD
10gtp44 2811.3CACNA1B, TOR1A, GEMIN2, TH, TGM2
11kainate44 2811.3CACNA1B, HTT, TH
12cholesterol44 28 11 2413.3CACNA1B, HTT, CXCL10, SLC4A1, TSPAN7, LYN
13dids44 2811.3SLC4A1, RHD
14glutamate4410.3CACNA1B, HTT, TOR1A, TH, SLC4A1, TGM2
15histamine44 28 2412.2LYN, TH, CXCL9, CXCL10
16morphine44 49 28 1113.2TH, CXCL10, CACNA1B
17alanine4410.2CACNA1B, HTT, CXCL10, TH, SLC4A1, TGM2
18mibg4410.2CACNA1B, TH
19retinoic acid44 2411.2HTT, NKX2-1, CXCL10, TH, LYN, TGM2
20cysteine4410.2XK, CACNA1B, HTT, TH, SLC4A1, TGM2
21atp44 2811.1TGM2, CACNA1B, HTT, RHD, CXCL10, CXCL9
22tyrosine4410.0HTT, TOR1A, RHD, NKX2-1, CXCL10, CXCL9
23nimodipine44 28 1112.0TH, CACNA1B

GO Terms for genes affiliated with Chorea

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16Gene Ontology
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Biological processes related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.3NKX2-1, PAX8
2locomotory behaviorGO:00762610.0TH, NKX2-1, HTT, VPS13A, CACNA1B
3social behaviorGO:0351769.9HTT, TH, VPS13A

Molecular functions related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.3TGM2, CACNA1B, VPS13A, HTT, NKX2-1, GEMIN2

Products for genes affiliated with Chorea

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Sources for Chorea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet