MCID: CHR104
MIFTS: 46

Chorea malady

Summaries for Chorea

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Chorea is an abnormal involuntary movement disorder, one of a group of neurological disorders called which are caused by overactivity of the neurotransmitter dopamine in the areas of the brain that control movement. Chorea is characterized by brief, irregular contractions that are not repetitive or rhythmic, but appear to flow from one muscle to the next. Chorea often occurs with which adds twisting and writhing movements. Chorea is a primary feature of a progressive, hereditary movement disorder that appears in adults, but it may also occur in a variety of other conditions. occurs in a small percentage (20 percent) of children and adolescents as a complication of rheumatic fever. Chorea can also be induced by drugs (levodopa, anti-convulsants, and anti-psychotics) metabolic and endocrine disorders, and vascular incidents.

MalaCards: Chorea is related to chorea-acanthocytosis and huntington's disease. An important gene associated with Chorea is VPS13A (vacuolar protein sorting 13 homolog A (S. cerevisiae)), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Alpha-synuclein signaling. The compounds it 15 and cystamine have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and lung, and related mouse phenotypes are growth/size and behavior/neurological.

Wikipedia:64 Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of... more...

Aliases & Classifications for Chorea

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

chorea 44 61


Related Diseases for Chorea

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chorea family:

chorea familial benign

Diseases related to Chorea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1chorea-acanthocytosis31.3JPH3, VPS13A, XK
2huntington's disease30.9VPS13A, HTT, JPH3, TGM2
3parkinson's disease30.3TGM2, TH, TOR1A, HTT
4myoclonus-dystonia30.2TOR1A, SGCE
5graves' disease30.2PAX8, CXCL10, NKX2-1
6focal dystonia29.9TOR1A
7sjogren's syndrome29.9CXCL9
8dentatorubral-pallidoluysian atrophy29.9JPH3, HTT
9huntington disease-like 229.7JPH3
10pantothenate kinase-associated neurodegeneration29.7JPH3
11sydenham's chorea11.0
12acanthocytosis10.8
13benign hereditary chorea10.7
14chorea gravidarum10.7
15chorea minor10.4
16rheumatic fever10.4
17systemic lupus erythematosus10.3
18moyamoya disease10.3
19n syndrome10.3
20mcleod syndrome10.3
21antiphospholipid syndrome10.2
22athetosis10.2
23myoclonus10.2
24diabetic ketoacidosis10.2
25morvan's fibrillary chorea10.2
26pandas10.2
27ataxia10.2
28obsessive-compulsive disorder10.1
29chorea familial benign10.1
30levine-critchley syndrome10.1
31tremor10.1
32polycythemia vera10.1
33temporal lobe epilepsy10.1
34thyroiditis10.1
35thyrotoxicosis10.1
36chorea, remitting with nystagmus and cataracts10.1
37neuroacanthocytosis10.0XK
38lung cancer10.0NKX2-1
39neuroblastoma10.0TH
40thyroid agenesis10.0NKX2-1, PAX8
41congenital dyserythropoietic anemia10.0RHD, SLC4A1
42leukemia10.0LYN, RHD
43familial dystonia10.0SGCE, TOR1A
44hypothyroidism10.0PAX8, NKX2-1
45movement disease10.0SGCE, TH, TOR1A
46herpes simplex10.0TH, CXCL10
47dementia10.0HTT, CXCL10, TH
48kidney cancer10.0PAX8
49allergic contact dermatitis10.0CXCL9, CXCL10
50hereditary spherocytosis10.0RHD, SLC4A1

Graphical network of the top 20 diseases related to Chorea:



Diseases related to chorea

Clinical Features for Chorea

Drugs & Therapeutics for Chorea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chorea

Drug clinical trials:

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Search NIH Clinical Center for Chorea

Search CenterWatch for Chorea

Genetic Tests for Chorea

Anatomical Context for Chorea

Sources:
33MalaCards
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MalaCards organs/tissues related to Chorea:

33
Tongue, Brain, Lung, Whole blood, Cortex, Heart, Skeletal muscle, Small intestine, Thyroid, Breast, Monocytes, T cells, Temporal lobe, Globus pallidus, Thalamus, Caudate nucleus, Adrenal cortex, Pituitary

Animal Models for Chorea or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chorea

Sources:
51PubMed
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Articles related to Chorea:

(show top 50)    (show all 790)
idTitleAuthorsYear
1
Acute chorea-dystonia heralding diabetes mellitus. (24000205)
2013
2
Brain human monoclonal autoantibody from sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: implications in human disease. (24184556)
2013
3
Chorea and tick-borne encephalitis, Poland. (23968621)
2013
4
Psychiatric symptoms in a woman with chorea-acanthocytosis. (23592074)
2013
5
Dopaminergic innervation of the human subventricular zone: a comparison between Huntington's chorea and Parkinson's disease. (24093085)
2013
6
Chorea-acanthocytosis. (22258171)
2012
7
Expanding the phenomenology of benign hereditary chorea: evolution from chorea to myoclonus and dystonia. (21714005)
2011
8
The Wilson films--Huntington's chorea. (22170268)
2011
9
Sydenham's chorea. (21496581)
2011
10
Benign hereditary chorea: an update. (21292530)
2011
11
Non-ketotic hyperglycemic chorea-hemiballismus mimicking basal ganglia hemorrhage. (21871808)
2011
12
Drug-induced movement disorders and Syndenham's chorea in an antipsychotic-treated young child. (22040195)
2011
13
Chorea-ballism associated with nonketotic hyperglycaemia or diabetic ketoacidosis: characteristics of 25 patients in Korea. (21632136)
2011
14
MRI appearance of a cerebral cavernous malformation in the caudate nucleus before and after chorea onset. (21396825)
2011
15
Post-pump chorea--choreiform movements developing after pulmonary thromboendarterectomy for chronic pulmonary hypertension presenting as "functional" movement disorder. (21907066)
2011
16
Chorea in a child with Churg-Strauss syndrome. (20505631)
2010
17
Chorea-acanthocytosis with upper motor neuron degeneration and 3419_3420 delCA and 3970_3973 delAGTC VPS13A mutations. (19949804)
2010
18
Chorea-acanthocytosis without acanthocytes]. (19497603)
2010
19
Chorea as the presenting feature of neurosyphilis. (19587483)
2009
20
Systemic manifestations and rheumatic chorea. (18847627)
2008
21
Chorea associated with antiphospholipid antibodies in a patient with Kabuki syndrome. (17506095)
2007
22
Donepezil-induced chorea in Alzheimer's disease. (17990058)
2007
23
Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome. (17659641)
2007
24
Depressive and anxiety symptoms in Sydenham's chorea. (17343271)
2007
25
Severe childhood autosomal recessive muscular dystrophy, mental subnormality and chorea. (17114866)
2006
26
Nerve conduction study in Sydenham's chorea. (15551347)
2005
27
Ciprofloxacin-induced chorea. (15739219)
2005
28
Bilateral chorea-ballism after cardiac arrest. (15781800)
2005
29
UFMG Sydenham's chorea rating scale (USCRS): reliability and consistency. (15648075)
2005
30
Leber hereditary optic neuropathy with chorea and dementia resembling Huntington disease. (15623735)
2004
31
Magnetic resonance imaging and single-photon emission computed tomography changes in hypoglycemia-induced chorea. (15077249)
2004
32
Amphetamine-induced chorea in attention deficit-hyperactivity disorder. (15254949)
2004
33
Chorea can present long before other manifestations of primary antiphospholipid syndrome. (17146236)
2003
34
Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. (12819778)
2003
35
Tetrabenazine in the treatment of severe pediatric chorea. (12784277)
2003
36
Chorea and community in a nineteenth-century town. (12486915)
2002
37
Dopa-resistant parkinsonism, oculomotor disturbances, chorea, mirror movements, dyspraxia, and dementia: the expanding clinical spectrum of hypoparathyroidism. A case report. (11104223)
2000
38
High-signal basal ganglia on T1-weighted images in a patient with Sydenham's chorea. (9833896)
1998
39
Senile chorea: a multicenter prospective study. (9088388)
1997
40
Chorea gravidarum: a case report and review. (9294953)
1997
41
Sydenham's chorea. Clinical and therapeutic update. (9331612)
1997
42
Chorea as a presentation of herpes simplex encephalitis relapse. (8214342)
1993
43
A pedigree of amyotrophic chorea with acanthocytosis. (7417043)
1980
44
Abnormal occurrence of the ulnar nerve-hypothenar muscle H-reflex in Sydenham's chorea. (13907940)
1962
45
Papilledema in Sydenham's chorea. (13693517)
1961
46
Chorea gravidarum. (13504634)
1958
47
Chorea gravidarum. (13372615)
1956
48
Sydenham's chorea. II. Effects of hormone therapy. (14360739)
1955
49
Chorea gravis (Sydenham's chorea) treated with cortisone and ascorbic acid. (14859171)
1951
50
Enterococcus and Sydenham's Chorea. (20476019)
1934

Genetic Variations for Chorea

Expression for genes affiliated with Chorea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chorea

Search GEO for disease gene expression data for Chorea.

Pathways for genes affiliated with Chorea

Sources:
50PharmGKB, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 30KEGG
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Pathways related to Chorea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TH, CACNA1B
210.2TOR1A, TH, LYN
310.2TOR1A, TH, NKX2-1, HTT
4
Hide members
10.1LYN, CACNA1B, CXCL10, CXCL9

Compounds for genes affiliated with Chorea

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Chorea according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1it 154510.6JPH3, HTT
2cystamine4510.6TGM2, HTT
33-nitropropionic acid4510.6TH, HTT
4naoh4510.6RHD, SLC4A1
5sodium iodide4510.5NKX2-1, PAX8
6glucose4510.4SLC4A1, RHD, HTT
7forskolin45 50 1112.4HTT, NKX2-1, CXCL10, TH, PAX8
8sodium45 2411.4XK, CACNA1B, NKX2-1, SLC4A1, PAX8
9oxalate4510.4SLC4A1, RHD
10gtp45 2911.3CACNA1B, TOR1A, GEMIN2, TH, TGM2
11kainate45 2911.3CACNA1B, HTT, TH
12cholesterol45 29 11 2413.3CACNA1B, HTT, CXCL10, SLC4A1, TSPAN7, LYN
13dids45 2911.3SLC4A1, RHD
14glutamate4510.3CACNA1B, HTT, TOR1A, TH, SLC4A1, TGM2
15histamine45 29 2412.2LYN, TH, CXCL9, CXCL10
16morphine45 50 29 1113.2TH, CXCL10, CACNA1B
17alanine4510.2CACNA1B, HTT, CXCL10, TH, SLC4A1, TGM2
18mibg4510.2CACNA1B, TH
19retinoic acid45 2411.2HTT, NKX2-1, CXCL10, TH, LYN, TGM2
20cysteine4510.2XK, CACNA1B, HTT, TH, SLC4A1, TGM2
21atp45 2911.1TGM2, CACNA1B, HTT, RHD, CXCL10, CXCL9
22tyrosine4510.0HTT, TOR1A, RHD, NKX2-1, CXCL10, CXCL9
23nimodipine45 29 1112.0TH, CACNA1B

GO Terms for genes affiliated with Chorea

Sources:
16Gene Ontology
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Biological processes related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.3NKX2-1, PAX8
2locomotory behaviorGO:00762610.0TH, NKX2-1, HTT, VPS13A, CACNA1B
3social behaviorGO:0351769.9HTT, TH, VPS13A

Molecular functions related to Chorea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.3TGM2, CACNA1B, VPS13A, HTT, NKX2-1, GEMIN2

Products for genes affiliated with Chorea

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Sources for Chorea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet