MCID: CHR005
MIFTS: 48

Chorioamnionitis malady

Categories: Fetal diseases

Aliases & Classifications for Chorioamnionitis

Aliases & Descriptions for Chorioamnionitis:

Name: Chorioamnionitis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050697

Summaries for Chorioamnionitis

Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to hepatitis and tuberculosis. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Misoprostol and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

Related Diseases for Chorioamnionitis

Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.7 IL10 IL6 TNF
2 tuberculosis 29.2 CCL2 IL10 IL1B IL6 TNF
3 listeriosis 10.8
4 intussusception 10.3 IL1B TNF
5 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
6 funisitis 10.3
7 thymic neuroendocrine carcinoma 10.3 CXCL8 IL6 TNF
8 oculomotor nerve paralysis 10.3 CXCL8 IL1B IL6
9 common peroneal nerve lesion 10.3 CXCL8 IL1B IL6
10 esophagus lymphoma 10.3 CXCL8 IL6 TNF
11 bipolar i disorder 10.3 IL1B IL6 TNF
12 bullous retinoschisis 10.3 CXCL8 IL1B IL6
13 carbuncle 10.3 CXCL8 IL1B IL6
14 tinea capitis 10.3 IL1B IL6 TNF
15 measles 10.3 IL1B IL6 TNF
16 dextrocardia 10.3 IL1B IL6 TNF
17 orthostatic proteinuria 10.3 CXCL8 IL6 TNF
18 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IL1B TNF
19 vitreoretinopathy, neovascular inflammatory 10.3 CXCL8 IL6 MMP8
20 mineral metabolism disease 10.2 IL1B IL6 TNF
21 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
22 keratoconus 10.2 IL1B IL6 TNF
23 splenic artery aneurysm 10.2 IL1B IL6 TNF
24 coloboma of iris 10.2 CRP IL6
25 laryngotracheoesophageal cleft type 2 10.2 CRP IL1B IL6
26 joint disorders 10.2 CRP IL6 TNF
27 nasal cavity cancer 10.2 CXCL8 IL1B TNF
28 cerebellar disease 10.2 IL1A IL1B TNF
29 pyridoxal 5'-phosphate-dependent epilepsy 10.2 IL10 TNF
30 paranasal sinus sarcoma 10.2 CXCL8 IL6 TNF
31 cataract 10.2 CRP IL1B TNF
32 schwannoma of ureter 10.2 CCL2 CXCL8 IL6
33 autoimmune disease of central nervous system 10.2 CRP IL6 TNF
34 hidradenitis 10.2 CRP CXCL8 IL1B
35 pyloric stenosis, infantile hypertrophic, 2 10.2 CRP IL1B TNF
36 retinal vascular occlusion 10.2 CXCL8 IL1B TNF
37 glandular cystitis 10.2 IL1B IL6 OXT
38 tau syndrome 10.2 IL1B TNF
39 carotenemia 10.2 CRP IL6 TNF
40 wilkes stevenson syndrome 10.2 CRP CXCL8 IL1B
41 ulcerative proctitis 10.2 CCL2 CXCL8 TNF
42 urticaria 10.2 CRP IL1B TNF
43 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
44 glucose intolerance 10.2 CCL2 CXCL8 TNF
45 patau syndrome 10.2 CRP IL1B TNF
46 choanal atresia, bilateral 10.2 CCL2 IL6 TNF
47 chondroma 10.2 CRP IL6 TNF
48 smooth muscle tumor 10.2 CCL2 IL1A IL6
49 cutaneous candidiasis 10.2 CCL2 CXCL8
50 granulomatous hepatitis 10.2 CRP IL1B IL6

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis

Symptoms & Phenotypes for Chorioamnionitis

MGI Mouse Phenotypes related to Chorioamnionitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 IL10 IL1A IL1B IL6 MMP9 OXT
2 homeostasis/metabolism MP:0005376 10.03 CRP ELANE FLT1 IL10 IL1A IL1B
3 hematopoietic system MP:0005397 9.97 ELANE FLT1 IL10 IL1A IL1B IL6
4 immune system MP:0005387 9.93 CCL2 CRP ELANE FLT1 IL10 IL1A
5 integument MP:0010771 9.56 IL10 IL1A IL1B IL6 MMP9 OXT
6 neoplasm MP:0002006 9.28 ELANE IL10 IL1A IL1B IL6 MMP8

Drugs & Therapeutics for Chorioamnionitis

Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 4,Phase 2 59122-46-2 5282381
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-56-6 439302 53477758
3
Ampicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 69-53-4 6249
4
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
5
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
6
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
7
Povidone-iodine Approved Phase 4 25655-41-8
8 Clindamycin palmitate Phase 4
9 Clindamycin phosphate Phase 4
10 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
11 Gentamicins Phase 4,Phase 2,Phase 3
12 Anesthetics Phase 4,Phase 3,Phase 1
13 Oxytocics Phase 4,Phase 3,Phase 2
14 Antacids Phase 4,Phase 2
15 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
16 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Ulcer Agents Phase 4,Phase 2
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
20 Antitubercular Agents Phase 4,Phase 3,Phase 2
21 Progestins Phase 4,Phase 3,Phase 2
22 Hormone Antagonists Phase 4,Phase 3,Phase 2
23 Hormones Phase 4,Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
25 cefuroxime axetil Phase 4
26 Vaccines Phase 4
27
Nevirapine Approved Phase 3 129618-40-2 4463
28
Erythromycin Approved, Vet_approved Phase 3 114-07-8 12560
29
Clarithromycin Approved Phase 3 81103-11-9 84029
30
Metronidazole Approved Phase 3,Phase 2 443-48-1 4173
31
Josamycin Approved Phase 3 16846-24-5 5282165
32
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 9552079 2713
33
Cefazolin Approved Phase 3 25953-19-9 656510 33255
34
Dinoprostone Approved Phase 3 363-24-6 5280360
35
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
36
Sulbactam Approved Phase 2, Phase 3 68373-14-8
37 Analgesics Phase 3,Phase 2
38 Tocolytic Agents Phase 3,Phase 2
39 Peripheral Nervous System Agents Phase 3,Phase 2
40 Central Nervous System Depressants Phase 3,Phase 1
41 Chlorhexidine gluconate Phase 3
42 calcium channel blockers Phase 3
43 Cytochrome P-450 CYP3A Inducers Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 Nucleic Acid Synthesis Inhibitors Phase 3
47 Dermatologic Agents Phase 3
48 Disinfectants Phase 3
49 Anesthetics, Local Phase 3
50 Erythromycin Estolate Phase 3

Interventional clinical trials:

(show top 50) (show all 107)
id Name Status NCT ID Phase
1 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4
2 Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester Completed NCT00324519 Phase 4
3 A Trial of Oral Misoprostol for Labor Augmentation Completed NCT00906347 Phase 4
4 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4
5 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
6 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4
7 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Recruiting NCT02487797 Phase 4
8 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Recruiting NCT02783170 Phase 4
9 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4
10 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4
11 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4
12 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455 Phase 4
13 Intrapartum Fever: Antibiotics Versus no Treatment Not yet recruiting NCT03168178 Phase 4
14 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4
15 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
16 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4
17 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
18 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3
19 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3
20 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3
21 Combined Anesthesia for Labor and Maternal Temperature Completed NCT01078519 Phase 3
22 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3
23 Chlorhexidine Vaginal and Infant Wash in Pakistan Completed NCT00121394 Phase 3
24 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
25 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3
26 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3
27 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3
28 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Recruiting NCT02716922 Phase 3
29 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Recruiting NCT02716909 Phase 3
30 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Recruiting NCT02678026 Phase 3
31 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Active, not recruiting NCT00879190 Phase 2, Phase 3
32 Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Terminated NCT00946088 Phase 2, Phase 3
33 Can Safety Planning Improve Perinatal Outcomes Among Pregnant Women Exposed to Intimate Partner Violence? Withdrawn NCT00831831 Phase 3
34 Amniotomy and Oxytocin for Augmentation of Labour Unknown status NCT02318121 Phase 2
35 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2
36 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Completed NCT00724594 Phase 1, Phase 2
37 Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy Completed NCT00153517 Phase 2
38 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2
39 Randomized Trial Comparing Misoprostol and Foley Bulb for Labor Induction in the Preterm Gestation Completed NCT00325026 Phase 2
40 A Study on the Effects of Dextrose Solutions on the Course of Labor Completed NCT00569439 Phase 2
41 Acupuncture for the Prevention of Postdates Pregnancy Completed NCT00312585 Phase 2
42 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2
43 Reduction of Intrapartum Fever With Intravenous Acetaminophen Recruiting NCT02625454 Phase 2
44 Prevention of Preterm Birth With a Pessary in Triplet Recruiting NCT02601443 Phase 2
45 Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term Terminated NCT00890630 Phase 2
46 Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia Unknown status NCT00326521 Phase 1
47 Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies Not yet recruiting NCT02443961 Phase 1
48 Treatment of Chorioamnionitis After Delivery Unknown status NCT00814905
49 Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis Unknown status NCT00299637 Early Phase 1
50 Intrapartum Study of Sterile and Clean Gloves Unknown status NCT01852188

Search NIH Clinical Center for Chorioamnionitis

Genetic Tests for Chorioamnionitis

Anatomical Context for Chorioamnionitis

MalaCards organs/tissues related to Chorioamnionitis:

39
Placenta, Uterus, Lung, Brain, Colon, Neutrophil, Endothelial

Publications for Chorioamnionitis

Articles related to Chorioamnionitis:

(show top 50) (show all 642)
id Title Authors Year
1
Neutrophil extracellular traps in acute chorioamnionitis: AA mechanism of host defense. ( 28045214 )
2017
2
The Human Ureaplasma Species as Causative Agents of Chorioamnionitis. ( 27974410 )
2017
3
Chorioamnionitis and Neurocognitive Development at Age 2 Years. ( 26855093 )
2016
4
Alarmin high mobility group box-1 in maternal serum as a potential biomarker of chorioamnionitis-associated preterm birth. ( 27684473 )
2016
5
Re: Magnesium sulphate, chorioamnionitis, and neurodevelopment after preterm birth. ( 27206037 )
2016
6
Accuracy of several maternal seric markers for predicting histological chorioamnionitis after preterm premature rupture of membranes: a prospective and multicentric study. ( 27591714 )
2016
7
Differential immunophenotype of macrophages in acute and chronic chorioamnionitis. ( 27124669 )
2016
8
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop. ( 26855098 )
2016
9
Revisiting the diagnostic criteria of clinical chorioamnionitis in preterm birth. ( 27365145 )
2016
10
Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. ( 27036917 )
2016
11
Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term infants. ( 27023390 )
2016
12
Elevated C-reactive protein levels in histological chorioamnionitis at term: impact of funisitis on term neonates. ( 27450900 )
2016
13
Authors' reply re: Magnesium sulphate, chorioamnionitis, and neurodevelopment after preterm birth. ( 27206038 )
2016
14
Diagnostic value of amniotic fluid inflammatory biomarkers for subclinical chorioamnionitis. ( 27177518 )
2016
15
Chorioamnionitis at birth does not increase the risk of neurodevelopmental disability in premature infants with bronchopulmonary dysplasia. ( 27552089 )
2016
16
Diagnostic and Prognostic Value of Presepsin for Subclinical Chorioamnionitis in Pregnancies between 23-28 Week with Preterm Premature Rupture of the Membranes. ( 27994922 )
2016
17
Chorioamnionitis at Term: Definition, Diagnosis, and Implications for Practice. ( 27104601 )
2016
18
Contribution of Histologic Chorioamnionitis and Fetal Inflammatory Response Syndrome to Increased Risk of Brain Injury in Infants With Preterm Premature Rupture of Membranes. ( 27353694 )
2016
19
Aerococcus christensenii as Part of Severe Polymicrobial Chorioamnionitis in a Pregnant Woman. ( 27014376 )
2016
20
Is Ureaplasma spp. the leading causative agent of acute chorioamnionitis in women with preterm birth? ( 27756710 )
2016
21
Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants. ( 27015030 )
2016
22
Non-Invasive Prediction of Histologic Chorioamnionitis in Women with Preterm Premature Rupture of Membranes. ( 26847301 )
2016
23
Activation of the IL-1I^/CXCL1/MMP-10 axis in chorioamnionitis induced by inactivated Group B Streptococcus. ( 27780533 )
2016
24
Predictive value of maternal serum NF-I_B p65 and sTREM-1 for subclinical chorioamnionitis in premature rupture of membranes. ( 27521929 )
2016
25
Coexistence of Ureaplasma and chorioamnionitis is associated with prolonged mechanical ventilation. ( 27337221 )
2016
26
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis. ( 27852921 )
2016
27
Chorioamnionitis and Five-Year Neurodevelopmental Outcome in Preterm Infants. ( 27355828 )
2016
28
Histologic Chorioamnionitis and Funisitis After Laser Surgery for Twin-Twin Transfusion Syndrome. ( 27399997 )
2016
29
Association between preterm brain injury and exposure to chorioamnionitis during fetal life. ( 27905410 )
2016
30
Microbial invasion and histological chorioamnionitis upregulate neutrophil-gelatinase associated lipocalin in preterm prelabor rupture of membranes. ( 25424376 )
2016
31
Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Study. ( 26890440 )
2016
32
Association between maternal genital mycoplasma colonization and histologic chorioamnionitis in preterm births. ( 27197925 )
2016
33
Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response. ( 27763883 )
2016
34
Chorioamnionitis and subsequent bronchopulmonary dysplasia in very-low-birth weight infants: a 25-year cohort. ( 27583395 )
2016
35
Ureaplasma Infection Mediated Release of Matrix Metalloproteinase-9 and PGP - a Novel Mechanism of Preterm Rupture of Membranes and Chorioamnionitis. ( 27632777 )
2016
36
Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. ( 27629373 )
2016
37
The common vaginal commensal bacterium Ureaplasma parvum is associated with chorioamnionitis in extreme preterm labor. ( 26795404 )
2016
38
Clinical Chorioamnionitis at Term: The Amniotic Fluid Fatty acyl Lipidome. ( 27538821 )
2016
39
Candida chorioamnionitis: Report of two cases and review of literature. ( 27760473 )
2016
40
Augmented Th17-Type Immune Responses in Preterm Neonates Exposed to Histologic Chorioamnionitis. ( 27870827 )
2016
41
Histological chorioamnionitis shapes the neonatal transcriptomic immune response. ( 27318328 )
2016
42
Amnioinfusion for chorioamnionitis. ( 27556818 )
2016
43
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
44
Histological chorioamnionitis in pre-term pre-labor rupture of the membranes is associated with increased expression of galectin-3 by amniotic epithelium. ( 27690725 )
2016
45
Chorioamnionitis and early-onset neonatal infection. ( 27333860 )
2016
46
Chorioamnionitis appears not to be a Risk Factor for Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis. ( 27892517 )
2016
47
The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis. ( 26965447 )
2016
48
Inflammation, lipids and aortic intima-media thickness in newborns following chorioamnionitis. ( 27002899 )
2016
49
The Effect of Clinical Chorioamnionitis on Cesarean Delivery in the United States. ( 26841089 )
2016
50
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop. ( 27333345 )
2016

Variations for Chorioamnionitis

Expression for Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for Chorioamnionitis

Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CCL2 CRP CXCL8 ELANE IL10 IL1A
2
Show member pathways
13.7 CCL2 CXCL8 FLT1 IL10 IL1A IL1B
3
Show member pathways
13.57 CCL2 CXCL8 FLT1 IL10 IL1A IL1B
4
Show member pathways
13.45 CCL2 CXCL8 FLT1 IL10 IL1A IL1B
5
Show member pathways
13.41 CCL2 CXCL8 IL10 IL1A IL1B IL6
6
Show member pathways
13.35 CCL2 CXCL8 FLT1 IL10 IL1A IL1B
7
Show member pathways
13.05 CCL2 CXCL8 IL1A IL1B IL6 TLR4
8
Show member pathways
12.96 CCL2 CXCL8 IL10 IL1B IL6 MMP9
9
Show member pathways
12.92 CXCL8 IL10 IL1A IL1B IL6 TNF
10
Show member pathways
12.87 CCL2 CXCL8 IL1A IL1B IL6 TLR4
11
Show member pathways
12.78 FLT1 IL1A IL1B IL6 TLR4 TNF
12
Show member pathways
12.67 IL10 IL1A IL1B IL6 TLR4 TNF
13
Show member pathways
12.66 FLT1 IL1A IL1B TLR4 TNF
14
Show member pathways
12.65 CCL2 IL10 IL1B IL6 TNF
15 12.54 CCL2 IL10 IL1B TNF
16
Show member pathways
12.52 IL10 IL1A IL1B IL6 TNF
17
Show member pathways
12.43 CCL2 CRP IL1B IL6 TNF
18
Show member pathways
12.41 CCL2 CXCL8 IL1B IL6 MMP9 TNF
19
Show member pathways
12.36 CXCL8 IL1A IL6 TLR4 TNF
20
Show member pathways
12.35 IL10 IL1A IL1B TLR4 TNF
21
Show member pathways
12.34 CXCL8 IL1A IL1B IL6 TLR4 TNF
22 12.32 CXCL8 ELANE FLT1 IL6 MMP9
23 12.32 IL10 IL1A IL1B IL6 TLR4 TNF
24
Show member pathways
12.28 CXCL8 IL1B IL6 TLR4 TNF
25 12.25 IL6 MMP9 TLR4 TNF
26 12.25 CXCL8 IL10 IL1A IL1B IL6 TNF
27
Show member pathways
12.22 CXCL8 IL10 IL1A IL1B IL6 TNF
28 12.18 CCL2 IL1A IL1B MMP9 TNF
29 12.05 CCL2 IL1B IL6 MMP9 TNF
30 12.04 CXCL8 IL1A IL1B IL6
31
Show member pathways
12.04 IL10 IL1B IL6 TLR4 TNF
32
Show member pathways
12.02 IL1A IL1B TLR4
33
Show member pathways
12.01 ELANE MMP8 MMP9 TNF
34 12 CCL2 CXCL8 IL1A IL1B IL6 TNF
35 12 CCL2 CXCL8 IL1A IL1B IL6 MMP9
36 11.99 IL10 IL6 TNF
37 11.99 IL1A IL1B IL6 TNF
38 11.98 CXCL8 IL1B TLR4 TNF
39 11.97 CXCL8 IL10 IL1B IL6 TLR4 TNF
40
Show member pathways
11.93 IL1B IL6 TLR4
41 11.93 CXCL8 IL1A IL1B IL6 TLR4
42 11.92 CCL2 CXCL8 IL10 IL1A IL1B IL6
43 11.91 FLT1 IL6 TLR4
44
Show member pathways
11.89 CXCL8 IL6 TLR4
45 11.87 IL10 IL1B IL6 TNF
46 11.86 CCL2 FLT1 MMP9
47 11.83 IL10 IL6 TLR4 TNF
48 11.82 IL10 IL1B TNF
49 11.79 CXCL8 IL10 IL1A IL1B IL6 TLR4
50 11.73 CCL2 CXCL8 IL1B IL6 MMP9 TNF

GO Terms for Chorioamnionitis

Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CCL2 CRP CXCL8 ELANE FLT1 IL10
2 extracellular space GO:0005615 9.44 CCL2 CRP CXCL8 ELANE FLT1 IL10
3 secretory granule GO:0030141 9.33 ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL2 IL6 TLR4 TNF
2 positive regulation of gene expression GO:0010628 9.97 CRP IL1A IL1B IL6 TLR4 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.95 CCL2 IL1A IL1B IL6
4 cellular response to tumor necrosis factor GO:0071356 9.92 CCL2 CXCL8 IL6
5 activation of MAPK activity GO:0000187 9.91 IL1B TLR4 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TLR4 TNF
7 extracellular matrix disassembly GO:0022617 9.9 ELANE MMP8 MMP9
8 cellular response to interleukin-1 GO:0071347 9.9 CCL2 CXCL8 IL6
9 cellular response to organic cyclic compound GO:0071407 9.9 CCL2 IL1B TNF
10 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 TNF
11 positive regulation of JNK cascade GO:0046330 9.89 IL1B TLR4 TNF
12 positive regulation of angiogenesis GO:0045766 9.89 CXCL8 FLT1 IL1A IL1B
13 neutrophil chemotaxis GO:0030593 9.88 CCL2 CXCL8 IL1B
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 ELANE IL6 TNF
15 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.87 IL10 IL1B IL6 TNF
16 positive regulation of MAP kinase activity GO:0043406 9.86 ELANE FLT1 TNF
17 humoral immune response GO:0006959 9.86 CCL2 IL6 TNF
18 immune response GO:0006955 9.86 CCL2 CXCL8 IL10 IL1A IL1B IL6
19 response to lipopolysaccharide GO:0032496 9.85 CCL2 ELANE IL10 IL1B IL6 TLR4
20 response to activity GO:0014823 9.84 CCL2 IL10 OXT
21 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
22 monocyte chemotaxis GO:0002548 9.83 CCL2 FLT1 IL6
23 cellular response to estradiol stimulus GO:0071392 9.82 CCL2 IL10 IL6
24 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
25 response to bacterium GO:0009617 9.79 CCL2 IL6 TLR4
26 protein kinase B signaling GO:0043491 9.78 CCL2 IL1B TNF
27 positive regulation of cytokine secretion GO:0050715 9.77 IL10 IL1A TNF
28 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR4 TNF
29 negative regulation of lipid catabolic process GO:0050995 9.75 IL1B TNF
30 negative regulation of interleukin-6 production GO:0032715 9.75 IL10 TLR4 TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IL1B TNF
32 cellular response to hepatocyte growth factor stimulus GO:0035729 9.74 IL10 IL6
33 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.74 FLT1 IL1B
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 CCL2 TLR4
35 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
36 response to molecule of bacterial origin GO:0002237 9.74 CXCL8 IL10
37 PERK-mediated unfolded protein response GO:0036499 9.73 CCL2 CXCL8
38 leukocyte migration involved in inflammatory response GO:0002523 9.73 CCL2 ELANE
39 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.73 IL1A IL1B
40 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
41 positive regulation of NF-kappaB import into nucleus GO:0042346 9.73 IL1B TLR4 TNF
42 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IL1B IL6 TLR4 TNF
43 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.72 IL1A IL1B
44 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
45 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 TLR4
46 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.72 IL10 MMP9 TNF
47 response to glucocorticoid GO:0051384 9.72 CCL2 IL10 IL6 OXT TNF
48 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
49 positive regulation of prostaglandin secretion GO:0032308 9.71 IL1B OXT
50 response to yeast GO:0001878 9.71 ELANE IL6

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CXCL8 IL10 IL1A IL1B IL6
2 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B

Sources for Chorioamnionitis

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
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44 MGI
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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