MCID: CHR005
MIFTS: 52

Chorioamnionitis malady

Summaries for Chorioamnionitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards: Chorioamnionitis is related to funisitis and sepsis. An important gene associated with Chorioamnionitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Monoamine Transport and TGF-Beta Pathway. The compounds tenidap and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain, and related mouse phenotypes are tumorigenesis and skeleton.

Wikipedia:64 Chorioamnionitis is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial... more...

Aliases & Classifications for Chorioamnionitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

chorioamnionitis 8 10 45 61


External Ids:

Disease Ontology8 DOID:0050697

Related Diseases for Chorioamnionitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to chorioamnionitis

Clinical Features for Chorioamnionitis

Drugs & Therapeutics for Chorioamnionitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Chorioamnionitis

Anatomical Context for Chorioamnionitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Chorioamnionitis:

33
Skin, Spinal cord, Brain, Lung, Spleen, Uterus, Bone marrow, Thymus, Heart, Small intestine, Colon, Placenta, Monocytes, T cells, B cells, Endothelial, Fetal brain, Fetal lung

Animal Models for Chorioamnionitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chorioamnionitis

Sources:
51PubMed
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Articles related to Chorioamnionitis:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Histological chorioamnionitis: effects on premature delivery and neonatal prognosis. (23639744)
2013
2
uPAR, IL-33, and ST2 Values as a Predictor of Subclinical Chorioamnionitis in Preterm Premature Rupture of Membranes. (24304137)
2013
3
Neonatal outcome of preterm infants born to mothers with abnormal genital tract colonisation and chorioamnionitis: a cohort study. (23158015)
2013
4
Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone. (23653388)
2013
5
Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep. (23410690)
2013
6
The effect of histological chorioamnionitis on the short-term outcome of preterm infants a8o32 weeks: a single-center study. (24093223)
2013
7
Early-onset neonatal sepsis in Dhaka, Bangladesh: risk associated with maternal bacterial colonisation and chorioamnionitis. (23822861)
2013
8
Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. (21860336)
2012
9
Umbilical cord blood levels of cortisol and dehydroepiandrosterone sulfate in preterm prelabor rupture of membrane pregnancies complicated by the presence of histological chorioamnionitis. (22489862)
2012
10
Chorioamnionitis and diagnostic value of C-reactive protein, erythrocyte sedimentation rate and white blood cell count in its diagnosis among pregnant women with premature rupture of membranes. (24163955)
2012
11
Acute histologic chorioamnionitis at term: nearly always noninfectious. (22412842)
2012
12
Acute chorioamnionitis at term caused by the oral pathogen Fusobacterium nucleatum. (23115747)
2012
13
Ovine fetal thymus response to lipopolysaccharide-induced chorioamnionitis and antenatal corticosteroids. (22693607)
2012
14
Chorioamnionitis due to Arcanobacterium haemolyticum. (21572617)
2011
15
Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep. (21493953)
2011
16
Chorioamnionitis, lung function and bronchopulmonary dysplasia in prematurely born infants. (21097839)
2011
17
Maternal markers for detecting early-onset neonatal infection and chorioamnionitis in cases of premature rupture of membranes at or after 34 weeks of gestation: a two-center prospective study. (21470433)
2011
18
NICU admission hypothermia, chorioamnionitis, and cytokines. (21838601)
2011
19
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. (20727688)
2010
20
Chorioamnionitis bites the lung. (20633896)
2010
21
Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. (20172951)
2010
22
Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants. (19710675)
2010
23
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. (19164476)
2009
24
Neonatal outcomes in the setting of preterm premature rupture of membranes complicated by chorioamnionitis. (19557664)
2009
25
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
26
Subphrenic abscess after cesarean section in term pregnancy complicated by chorioamnionitis. (18570582)
2008
27
Neurodevelopmental outcome of very-low-birth-weight infants with chorioamnionitis. (18265542)
2007
28
Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery. (17547879)
2007
29
Pre-term pre-labour rupture of membranes: effect of chorioamnionitis on overall neonatal outcome. (17130019)
2006
30
Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. (15611353)
2005
31
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
32
Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. (14745724)
2004
33
Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. (14600137)
2003
34
Tumor necrosis factor-alpha promoter gene polymorphism -308 and chorioamnionitis. (12850624)
2003
35
Puerperal adrenal abscess complicating chorioamnionitis. (11975955)
2002
36
Methicillin-resistant Staphylococcus aureus chorioamnionitis: a rare cause of fetal death in our community. (11926653)
2002
37
Early neonatal brain injury in histologic chorioamnionitis. (11148520)
2001
38
Thymic size and chorioamnionitis in very low birth weight infants. (11174640)
2001
39
Chorioamnionitis and early-onset neonatal sepsis do not significantly affect levels of interleukin-6 in very low birth weight neonates]. (12092128)
2001
40
Cytokine production in chorioamnionitis. (10924750)
2000
41
Acute thymic involution in fetuses and neonates with chorioamnionitis. (11014581)
2000
42
Chronic chorioamnionitis: a clinicopathologic and immunohistochemical study. (9865833)
1998
43
Prevalence and risk factors of chorioamnionitis among adolescents. (9699762)
1998
44
Interleukin-8 level in maternal serum as a marker for screening of histological chorioamnionitis at term. (9184952)
1997
45
International Multicentre Term Prelabor Rupture of Membranes Study: evaluation of predictors of clinical chorioamnionitis and postpartum fever in patients with prelabor rupture of membranes at term. (9396886)
1997
46
Interleukin-6 expression in cord blood of patients with clinical chorioamnionitis. (8725257)
1996
47
Chorioamnionitis caused by Capnocytophaga: case report. (7631698)
1995
48
Bacteremia and chorioamnionitis due to cryptic genospecies of Haemophilus Influenzae biotype I. (8681986)
1995
49
Recurrent chorioamnionitis and second-trimester abortion because of an enterouterine fistula. (7675395)
1995
50
Chorioamnionitis and funisitis due to Corynebacterium kutscheri. (518110)
1979

Genetic Variations for Chorioamnionitis

Expression for genes affiliated with Chorioamnionitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for genes affiliated with Chorioamnionitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 30KEGG, 12EMD Millipore, 54Reactome, 60Tocris Bioscience, 4Cell Signaling Technology
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Pathways related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL1R1
2
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10.4FLT1
3
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10.4IL6, IL1R1
410.4TLR2, TLR4
510.4TLR2, TLR4
6
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10.4TLR4, TLR2
7
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10.4IL1R1, FLT1
8
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10.4TLR4, FLT1
9
Cytokine production by Th17 cells in CF (Mouse model)
10.3TLR4, IL8, IL6
1010.3TNF, IL8, IL6
1110.3ELANE, MMP8, LTF
1210.3ELANE, IL6, TNF
1310.3TNF, IL1B, IL6
1410.3TNF, IL1B, IL6
15
Hide members
10.3IL1B, IL1R1, IL1RN
1610.3TLR4, TNF, IL1R1
1710.3TLR4, IL8, IL1B, IL6
1810.3IL6, IL8, TLR2, TLR4
1910.3IL6, IL1B, IL8, TLR2
2010.3IL6, IL1B, IL8, TNF
21
Hide members
10.3TNF, IL8, IL1B, IL6
2210.3TNF, CRP, IL1B, IL6
23
Hide members
10.3IL1RN, IL1R1, IL1B, IL6
2410.3TNF, IL1R1, IL1B, IL6
2510.3TLR4, TNF, IL1B, IL6
26
Hide members
10.3IL1B, IL1R1, TLR2, TLR4
2710.3TLR4, TLR2, TNF, IL6
28
Hide members
10.3IL1B, IL1R1, TNF, TLR4
2910.2IL1B, TNF, TLR2, TLR4
3010.2IL1B, TNF, TLR2, TLR4
3110.2FLT1, HPGD, IL8, IL6, ELANE
3210.2TLR4, TNF, IL8, IL1B, IL6
3310.2TLR4, TNF, IL1R1, IL8, IL1B
3410.2TNF, IL1RN, IL8, IL1B, IL6
3510.2TLR4, TNF, IL1R1, IL1B, IL6
3610.2IL6, IL1B, TNF, TLR2, TLR4
37
Hide members
10.2TLR4, TLR2, TNF, IL1B, IL6
38
Hide members
10.2TLR4, TLR2, TNF, IL1R1, IL1B
39
Hide members
10.2TLR4, TLR2, TNF, IL1R1, IL1B
40
Hide members
10.2OXTR, OXT, IL1B, IL6, RAMP2
41
Hide members
10.2TLR4, TNF, IL1R1, IL8, IL1B, IL6
42
Hide members
10.2TLR4, TLR2, TNF, IL8, IL1B, IL6
4310.2TLR4, TLR2, TNF, IL8, IL1B, IL6
44
Hide members
10.2TLR4, TLR2, TNF, IL8, IL1B, IL6
45
Hide members
10.1TLR4, TLR2, TNF, IL1R1, IL8, IL1B
4610.1TLR4, TLR2, TNF, IL1R1, IL8, IL1B
47
Hide members
10.1TLR4, TLR2, TNF, FLT1, IL1R1, IL1B
48
Immune response Bacterial infections in normal airways
Hide members
10.0IL6, TLR4, TLR2, TNF, IL1RN, IL1R1
49
Hide members
10.0TLR4, TLR2, TNF, FLT1, IL1R1, IL8
50
Hide members
10.0TLR4, TLR2, S100A12, DEFB103B, IL1RN, IL1R1

Compounds for genes affiliated with Chorioamnionitis

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 210)
idCompoundScoreTop Affiliating Genes
1tenidap45 2911.8LTF, IL1R1
2endotoxin4510.8LTF, HPGD
3gabexate mesilate4510.8ELANE
4cycloheximide4510.8TLR2
5hydrocortisone45 2 60 1113.7FLT1, LTF, IL8, ELANE
6pentoxifylline45 1111.7LTF, IL1RN, IL1R1, ELANE
7cyclosporin a45 29 6012.6LTF, IL1R1, MMP8, ELANE
8h2o24510.6MMP8, FLT1, LTF, IL1RN, IL1R1
9anakinra45 1111.6IL1RN, IL1R1, IL1B, CRP, IL6, TNF
10superoxide45 2411.6MMP8, IL1B, LTF, TNF, ELANE
11hbd24510.5IL8, TLR4, TLR2, DEFB103B, IL1B, IL6
12prostaglandin4510.5IL1B, IL1R1, TNF, OXTR, HPGD, IL1RN
13indomethacin45 60 29 1113.5HPGD, IL1R1, OXTR, LTF
14gold sodium thiomalate4510.5IL8, IL1R1, TNF, IL1RN, IL1B
15sulfasalazine45 29 50 1113.5IL1RN, IL1B, CRP, IL1R1, IL8, TNF
16etanercept45 50 1112.5IL6, IL1R1, IL1RN, CRP, IL8, TNF
17zymosan4510.5TLR2, TNF, TLR4, LTF, IL1RN, ELANE
18polyinosinic-polycytidylic acid4510.5TLR2, IL8, IL1B, IL6, TLR4, TNF
19infliximab45 50 1112.5IL6, IL1R1, IL1RN, CRP, IL1B, TLR4
20peptidoglycan45 2911.5IL1RN, IL1R1, IL8, IL1B, IL6, TNF
21lipoteichoic acid4510.5TLR4, TLR2, TNF, IL1RN, IL1R1, IL8
22il 104510.5IL1RN, TNF, TLR2, TLR4, IL1R1, IL8
23polymyxin b4510.5IL6, TLR2, TNF, LTF, IL1RN, TLR4
24poly(i-c)4510.5TLR4, TNF, IL1B, IL6, TLR2, IL8
25ivig4510.5S100A12, TNF, IL1RN, IL1R1, IL6, CRP
26adalimumab45 50 1112.5TNF, CRP, IL1RN, IL1R1, IL6
27ccl345 2911.5IL1R1, IL8, TNF, IL1B, IL6, PTX3
28rantes4510.4IL1R1, TLR2, IL1B, IL6, TNF, TLR4
29neopterin4510.4ELANE, IL6, IL1B, IL8, IL1R1, IL1RN
30il-124510.4IL8, IL6, IL1B, TNF, IL1R1
31leukotriene b445 60 2412.4ELANE, TLR2, LTF, HPGD, IL1RN, IL1R1
32fibrinogen4510.3IL1RN, IL6, IL1R1, MMP8, ELANE, LTF
33n acetylcysteine4510.3IL6, IL1R1, TLR4, TNF, CRP, IL1B
34sb 20358045 6011.3IL6, TLR2, IL1R1, IL8, TNF, IL1RN
35simvastatin45 50 60 29 11 2415.3IL6, TLR4, TLR2, TNF, CRP, IL1RN
36imiquimod45 29 60 1113.3TLR4, TLR2, IL6, IL8, TNF
37lactate4510.3TLR4, ELANE, MMP8, IL6, IL8, IL1R1
38dexamethasone45 50 29 1113.3PTX3, RAMP2, IL6, IL1R1, HPGD, OXTR
39fmlp4510.3IL1RN, ELANE, LTF
40actinomycin d4510.3IL1R1, PTX3, IL6, IL1B, IL8, LTF
41hyaluronic acid45 2411.3ELANE, IL1RN, IL1R1, IL8, IL1B, LTF
42leflunomide50 45 1112.2TNF, IL1R1, IL6, IL1RN, IL1B
43polysulfone4510.2IL1RN, ELANE, IL1R1, IL1B
44nitric oxide45 11 2412.2IL1R1, IL6, FLT1, IL8, OXT, IL1B
45vegf4510.1LTF, OXT, OXTR, FLT1, TNF, TLR2
46serine4510.1LTF, OXT, FLT1, TNF, IL8, TLR2
47histamine45 29 2412.1TLR4, TLR2, TNF, LTF, IL1RN, IL1B
48retinoic acid45 2411.1OXT, TLR4, TLR2, TNF, LTF, IL1RN
49cysteine4510.0DEFB103B, TLR2, TLR4, IL8, IL1R1, OXT
50alanine459.7LTF, HPGD, IL1RN, IL1R1, IL6, OXTR

GO Terms for genes affiliated with Chorioamnionitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.3OXT, LTF, IL1B, ELANE
2cell surfaceGO:00998610.2TLR2, TNF, IL1R1, RAMP2, ELANE
3extracellular spaceGO:00561510.1TNF, CRP, FLT1, OXT, IL1RN, IL8
4integral to plasma membraneGO:00588710.0TLR4, TLR2, TNF, FLT1, OXTR, IL1R1
5external side of plasma membraneGO:00989710.0TLR4, TLR2, TNF, IL6
6extracellular regionGO:0055769.9ELANE, S100A12, TNF, CRP, OXT, LTF
7plasma membraneGO:0058869.9TLR2, S100A12, TNF, CRP, FLT1, OXTR

Biological processes related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:04507910.8IL6, ELANE
2negative regulation of lipid storageGO:01088810.8TNF, CRP, IL6
3positive regulation of norepinephrine secretionGO:01070110.7OXT, OXTR
4chronic inflammatory response to antigenic stimulusGO:00243910.7IL1RN, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:06055910.7TNF, IL1B
6positive regulation of interleukin-8 biosynthetic processGO:04541610.7TLR4, TNF, ELANE
7sequestering of triglycerideGO:03073010.7TNF, IL1B
8positive regulation of interleukin-8 productionGO:03275710.7TLR4, TLR2, IL1B
9negative regulation of growth of symbiont in hostGO:04413010.7ELANE, TNF, TLR2
10monocyte chemotaxisGO:00254810.7IL6, FLT1, S100A12
11negative regulation of gastric acid secretionGO:06045510.7OXTR, OXT
12positive regulation of chemokine productionGO:03272210.7TLR4, TLR2, TNF, IL6
13acute-phase responseGO:00695310.7IL6, IL1RN, CRP
14positive regulation of penile erectionGO:06040610.7OXTR, OXT
15defense response to Gram-positive bacteriumGO:05083010.7IL6, CRP, TNF, TLR2
16positive regulation of interferon-gamma productionGO:03272910.7TLR4, TNF, IL1B
17positive regulation of heterotypic cell-cell adhesionGO:03411610.7TNF, IL1B
18response to progesterone stimulusGO:03257010.7RAMP2, OXT, OXTR
19positive regulation of NF-kappaB import into nucleusGO:04234610.7IL1B, TNF, TLR2, TLR4
20lipopolysaccharide-mediated signaling pathwayGO:03166310.7TLR4, TLR2, TNF, IL1B
21neutrophil chemotaxisGO:03059310.7S100A12, IL8, IL1B
22positive regulation of smooth muscle cell proliferationGO:04866110.7ELANE, IL6, TNF
23response to yeastGO:00187810.7PTX3, ELANE
24humoral immune responseGO:00695910.7TNF, LTF, IL6
25response to glucocorticoid stimulusGO:05138410.7TNF, OXT, IL1RN, IL6
26positive regulation of MAP kinase activityGO:04340610.6S100A12, TNF, FLT1, ELANE
27positive regulation of interleukin-6 productionGO:03275510.6TLR4, TLR2, TNF, IL1B, IL6
28positive regulation of fever generationGO:03162210.6IL1B, TNF
29positive regulation of macrophage cytokine productionGO:06090710.6TLR4, TLR2
30female pregnancyGO:00756510.6OXTR, OXT, HPGD, IL1RN, RAMP2
31sperm ejaculationGO:04271310.6OXTR, OXT
32positive regulation of inflammatory responseGO:05072910.6TLR4, TLR2, S100A12
33memoryGO:00761310.6OXTR, OXT, IL1RN
34positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.6TLR4, S100A12, TNF, LTF, IL1B
35positive regulation of JNK cascadeGO:04633010.6TLR4, TNF, IL1B
36positive regulation of prostaglandin secretionGO:03230810.6OXT, IL1B
37positive regulation of nitric oxide biosynthetic processGO:04542910.6PTX3, IL6, IL1B, TNF, TLR2, TLR4
38immune responseGO:00695510.6TLR4, TLR2, IL1RN, IL1R1, IL8, IL1B
39cellular response to lipoteichoic acidGO:07122310.6TLR4, TLR2
40epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.5TNF, IL6
41positive regulation of NF-kappaB transcription factor activityGO:05109210.5TLR4, TLR2, S100A12, TNF, LTF, IL1B
42response to estradiol stimulusGO:03235510.5RAMP2, OXT, OXTR
43opsonizationGO:00822810.5CRP, PTX3
44positive regulation of uterine smooth muscle contractionGO:07047410.5OXTR, OXT
45inflammatory responseGO:00695410.5TLR2, S100A12, TNF, CRP, IL8, IL1B
46positive regulation of chemokine biosynthetic processGO:04508010.4TNF, IL1B
47maternal behaviorGO:04271110.4OXTR, OXT
48positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.3IL6, IL1B, TNF
49negative regulation of interleukin-17 productionGO:03270010.3TLR4, TLR2
50sleepGO:03043110.1OXT, OXTR

Molecular functions related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.3ELANE, IL1R1, TNF
2lipopolysaccharide receptor activityGO:00187510.1TLR2, TLR4

Products for genes affiliated with Chorioamnionitis

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  • Antibodies

Sources for Chorioamnionitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet