Aliases & Classifications for Chorioamnionitis

MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050697
UMLS 69 C0008495

Summaries for Chorioamnionitis

Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and preterm premature rupture of the membranes. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clindamycin and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and uterus, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

Related Diseases for Chorioamnionitis

Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 359)
# Related Disease Score Top Affiliating Genes
1 funisitis 31.2 CXCL8 IL1B IL6
2 preterm premature rupture of the membranes 31.2 CXCL8 IL6 MMP8
3 vaginitis 30.9 CXCL8 IL1B IL6
4 cerebral palsy 30.7 IL1B IL6 TNF
5 bronchopulmonary dysplasia 30.3 CXCL8 ELANE FLT1
6 neutrophilia, hereditary 30.1 CRP IL6
7 endometritis 30.1 IL1B IL6 OXT TNF
8 haemophilus influenzae 30.0 CXCL8 IL1B TNF
9 eclampsia 29.9 FLT1 OXT TNF
10 newborn respiratory distress syndrome 29.7 CXCL8 ELANE IL1B
11 bacteriuria 29.6 CXCL8 IL6 TLR4
12 septic arthritis 29.5 CRP CXCL8 TLR4
13 endometriosis 29.5 CCL2 CXCL8 IL1B IL6
14 vasculitis 29.5 CCL2 CRP ELANE TNF
15 respiratory failure 29.4 CRP CXCL8 ELANE TNF
16 toxic shock syndrome 29.1 CXCL8 IL1B IL6 TLR4 TNF
17 lung disease 29.1 CCL2 CXCL8 ELANE IL1B MMP9 TNF
18 otitis media 29.1 CXCL8 IL1B IL6 TLR4 TNF
19 pertussis 29.0 IL1A IL1B IL6 TLR4 TNF
20 crohn's disease 29.0 CRP IL1B IL6 TLR4 TNF
21 perinatal necrotizing enterocolitis 28.9 CRP CXCL8 IL1B IL6 TLR4 TNF
22 appendicitis 28.8 CRP CXCL8 IL1B IL6 MMP8 MMP9
23 bacterial vaginosis 28.7 CXCL8 IL1A IL1B IL6 TLR4 TNF
24 chlamydia 28.7 CRP CXCL8 IL1B IL6 TLR4 TNF
25 arthritis 28.5 CCL2 CXCL8 IL1A IL1B IL6 MMP9
26 pneumonia 27.9 CCL2 CRP CXCL8 ELANE IL1B IL6
27 asthma 27.0 CCL2 CXCL8 ELANE IL1A IL1B IL1R1
28 malaria 26.5 CCL2 CRP CXCL8 IL1A IL1B IL1R1
29 listeriosis 11.0
30 scorpion envenomation 10.6 IL6 TNF
31 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
32 polyposis, gastric 10.5 IL1B TNF
33 critical limb ischemia 10.5 IL6 TNF
34 tungiasis 10.5 CXCL8 TNF
35 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
36 staphylococcal toxic shock syndrome 10.5 IL1B TNF
37 null-cell leukemia 10.5 IL6 TNF
38 cold agglutinin disease 10.5 CRP IL6
39 kashin-beck disease 10.5 IL1B TNF
40 leukoregulin 10.5 CXCL8 IL1A
41 scabies 10.5 CXCL8 IL1A
42 acute cholangitis 10.5 CRP IL6
43 skin conditions 10.5 IL1A TNF
44 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6 TNF
45 recurrent corneal erosion 10.4 CXCL8 IL1B IL6
46 bagassosis 10.4 CXCL8 IL1B IL6
47 retinitis pigmentosa 55 10.4 IL6 TNF
48 cardiogenic shock 10.4 CRP IL6
49 meconium aspiration syndrome 10.4 CXCL8 IL6 TNF
50 slow-channel congenital myasthenic syndrome 10.4 CRP CXCL8

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis

Symptoms & Phenotypes for Chorioamnionitis

MGI Mouse Phenotypes related to Chorioamnionitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 OXT IL1B TLR4 IL1R1 CRP IL6
2 homeostasis/metabolism MP:0005376 10.03 OXT IL1B TLR4 IL1R1 CRP IL6
3 hematopoietic system MP:0005397 9.97 MMP9 IL1A IL1B TLR4 IL1R1 IL6
4 immune system MP:0005387 9.93 IL1B TLR4 IL1R1 TNF CCL2 CRP
5 integument MP:0010771 9.56 IL1A OXT IL1B TLR4 IL1R1 IL6
6 neoplasm MP:0002006 9.28 IL1B TLR4 IL1R1 TNF IL6 ELANE

Drugs & Therapeutics for Chorioamnionitis

Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Misoprostol Approved Phase 4,Phase 2 59122-46-2 5282381
3
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-56-6 53477758 439302
4
Ampicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 69-53-4 6249
5
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
6
Dinoprostone Approved Phase 4,Phase 3 363-24-6 5280360
7
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
8
Povidone-iodine Approved Phase 4 25655-41-8
9
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Clindamycin palmitate Phase 4
13 Clindamycin phosphate Phase 4
14 Antacids Phase 4,Phase 2
15 Anti-Ulcer Agents Phase 4,Phase 2
16 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
17 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1
18 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
19 Antitubercular Agents Phase 4,Phase 3,Phase 2
20 Analgesics Phase 4,Phase 3,Phase 2
21 Gentamicins Phase 4,Phase 2,Phase 3
22 Hormone Antagonists Phase 4,Phase 3,Phase 2
23 Hormones Phase 4,Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
25 Progestins Phase 4,Phase 3,Phase 2
26 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2
27 cefuroxime axetil Phase 4
28 Vaccines Phase 4
29
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
30
Metronidazole Approved Phase 3,Phase 2 443-48-1 4173
31
Nevirapine Approved Phase 3 129618-40-2 4463
32
Cefazolin Approved Phase 3 25953-19-9 33255 656510
33
Clarithromycin Approved Phase 3 81103-11-9 84029
34
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 2713 9552079
35
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
36
Josamycin Approved, Investigational Phase 3 16846-24-5 5282165
37
Methenamine Approved, Vet_approved Phase 3 100-97-0 4101
38
Sulbactam Approved Phase 2, Phase 3 68373-14-8
39 Sultamicillin Approved, Investigational Phase 2, Phase 3 76497-13-7
40 Anesthetics Phase 3,Phase 1
41 Central Nervous System Depressants Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 3,Phase 2
43 Tocolytic Agents Phase 3,Phase 2
44 Anti-HIV Agents Phase 3
45 Antiparasitic Agents Phase 3,Phase 2
46 Antiprotozoal Agents Phase 3,Phase 2
47 Anti-Retroviral Agents Phase 3
48 Antiviral Agents Phase 3,Phase 1,Phase 2
49 Cytochrome P-450 CYP3A Inducers Phase 3
50 Erythromycin Estolate Phase 3

Interventional clinical trials:

(show top 50) (show all 118)

# Name Status NCT ID Phase Drugs
1 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
2 Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester Completed NCT00324519 Phase 4 misoprostol
3 A Trial of Oral Misoprostol for Labor Augmentation Completed NCT00906347 Phase 4 Misoprostol;Oxytocin
4 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4 Vaginal micronized progesterone
5 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
6 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
7 Intrapartum Fever: Antibiotics Versus no Treatment Recruiting NCT03168178 Phase 4 Standard Antibiotic Treatment
8 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Recruiting NCT02487797 Phase 4 Oxytocin
9 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Recruiting NCT02783170 Phase 4
10 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4
11 Foley Bulb With Oral Misoprostol for Induction of Labor Recruiting NCT03407625 Phase 4
12 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
13 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
14 Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes Recruiting NCT03310333 Phase 4 Propess® (dinoprostone)
15 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
16 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
17 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4 Buccal Misoprostol;Vaginal misoprostol
18 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
19 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
20 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
21 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
22 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
23 Combined Anesthesia for Labor and Maternal Temperature Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
24 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
25 Chlorhexidine Vaginal and Infant Wash in Pakistan Completed NCT00121394 Phase 3
26 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3
27 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
28 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
29 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
30 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Recruiting NCT02716922 Phase 3
31 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Recruiting NCT02716909 Phase 3
32 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Active, not recruiting NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
33 Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization Not yet recruiting NCT03407157 Phase 3
34 Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Terminated NCT00946088 Phase 2, Phase 3 Progesterone;Polyethylene glycol&hydrogenated vegetable oil.
35 Can Safety Planning Improve Perinatal Outcomes Among Pregnant Women Exposed to Intimate Partner Violence? Withdrawn NCT00831831 Phase 3
36 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
37 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Completed NCT00724594 Phase 1, Phase 2 N-acetylcysteine;Control
38 Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy Completed NCT00153517 Phase 2 oral versus vaginal metronidazole
39 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
40 Amniotomy and Oxytocin for Augmentation of Labour Completed NCT02318121 Phase 2 Oxytocin
41 Randomized Trial Comparing Misoprostol and Foley Bulb for Labor Induction in the Preterm Gestation Completed NCT00325026 Phase 2 Misoprostol
42 A Study on the Effects of Dextrose Solutions on the Course of Labor Completed NCT00569439 Phase 2 D5NS;D10NS;NS
43 Acupuncture for the Prevention of Postdates Pregnancy Completed NCT00312585 Phase 2
44 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
45 Reduction of Intrapartum Fever With Intravenous Acetaminophen Recruiting NCT02625454 Phase 2 Intravenous Acetaminophen;Oral Acetaminophen
46 Prevention of Preterm Birth With a Pessary in Triplet Recruiting NCT02601443 Phase 2
47 Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term Terminated NCT00890630 Phase 2 Oxytocin
48 Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia Unknown status NCT00326521 Phase 1
49 Foley Labor Induction Trial at Term and in PROM Completed NCT02098421 Phase 1 Oxytocin
50 Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies Not yet recruiting NCT02443961 Phase 1

Search NIH Clinical Center for Chorioamnionitis

Genetic Tests for Chorioamnionitis

Anatomical Context for Chorioamnionitis

MalaCards organs/tissues related to Chorioamnionitis:

38
Placenta, Brain, Uterus, Lung, Cervix, Testes, Colon

Publications for Chorioamnionitis

Articles related to Chorioamnionitis:

(show top 50) (show all 684)
# Title Authors Year
1
Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. ( 29448926 )
2018
2
Case report of Staphylococcus epidermidis maternal sepsis and chorioamnionitis following fetoscopy. ( 29055131 )
2018
3
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta. ( 29402780 )
2018
4
The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. ( 29371755 )
2018
5
Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences. ( 29083107 )
2018
6
Case Report: Chorioamnionitis and Premature Delivery due to<i>Burkholderia pseudomallei</i>Infection in Pregnancy. ( 29363450 )
2018
7
Intrapartum Management of Chorioamnionitis. ( 29215424 )
2018
8
The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins. ( 29449803 )
2018
9
Prediction of histological chorioamnionitis and neonatal and infantile outcomes using procalcitonin in the umbilical cord blood and amniotic fluid at birth. ( 29315994 )
2018
10
Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? ( 28861110 )
2017
11
Genital tract GBS and rate of histologic chorioamnionitis in patients with preterm premature rupture of membrane. ( 28715920 )
2017
12
Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation. ( 28672752 )
2017
13
The Human Ureaplasma Species as Causative Agents of Chorioamnionitis. ( 27974410 )
2017
14
Histological Chorioamnionitis as a Risk Factor for Preterm Birth without Disturbing Fetal Heart Rate: A Case-Control Study. ( 29249732 )
2017
15
Histologic chorioamnionitis does not modulate the oxidative stress and antioxidant status in pregnancies complicated by spontaneous preterm delivery. ( 29132320 )
2017
16
Impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in preterm infants: A literature review. ( 28643657 )
2017
17
Chorioamnionitis and Management of Asymptomatic Infants a8Y35 Weeks Without Empiric Antibiotics. ( 28759393 )
2017
18
Intrauterine inflammation, infection, or both (Triple I): A new concept for chorioamnionitis. ( 29066072 )
2017
19
Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. ( 28936902 )
2017
20
Quality and Clinical Outcomes Associated with a Gentamicin Use System Change for Managing Chorioamnionitis. ( 29124501 )
2017
21
Urinary metabolomic analysis to identify preterm neonates exposed to histological chorioamnionitis: A pilot study. ( 29211784 )
2017
22
Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes. ( 28847437 )
2017
23
Chorioamnionitis following preterm premature rupture of membranes and fetal heart rate variability. ( 28945767 )
2017
24
Acquired hemophilia A manifesting as plasma transfusion-uncontrolled severe bleeding 2 weeks after chorioamnionitis-induced abortion. ( 28150393 )
2017
25
Preclinical chorioamnionitis dysregulates CXCL1/CXCR2 signaling throughout the placental-fetal-brain axis. ( 29117499 )
2017
26
Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes. ( 28700642 )
2017
27
Methicillin-sensitive Staphylococcus aureus chorioamnionitis and foetal death after mechanical induction of labour: a case report. ( 28901792 )
2017
28
Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort. ( 28583707 )
2017
29
Association between genital mycoplasmas, acute chorioamnionitis and fetal pneumonia in spontaneous abortions. ( 28599391 )
2017
30
Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis. ( 28161060 )
2017
31
Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations. ( 28873067 )
2017
32
Management of asymptomatic neonates born in the setting of chorioamnionitis: a safety comparison of the well-baby and intensive care setting. ( 28880259 )
2017
33
Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation. ( 28693123 )
2017
34
<i>Candida</i> Chorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome. ( 29180840 )
2017
35
Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis. ( 29275925 )
2017
36
Chorioamnionitis, IL-17A, and fetal origins of neurologic disease. ( 29271527 )
2017
37
Neonatal sepsis secondary to chorioamnionitis by Actinomyces neuii in a 25 weeks pregnant woman. ( 29150122 )
2017
38
Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review. ( 28814548 )
2017
39
Neutrophil extracellular traps in acute chorioamnionitis: AA mechanism of host defense. ( 28045214 )
2017
40
Chorioamnionitis due to Leptotrichia trevisanii. ( 29155162 )
2017
41
In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4(+) T Lymphocytes. ( 28947540 )
2017
42
High- but not low-grade histologic chorioamnionitis is associated with spontaneous preterm birth in a Swedish cohort. ( 28605945 )
2017
43
Augmented Th17-Type Immune Responses in Preterm Neonates Exposed to Histologic Chorioamnionitis. ( 27870827 )
2016
44
Inflammation, lipids and aortic intima-media thickness in newborns following chorioamnionitis. ( 27002899 )
2016
45
Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes. ( 27658190 )
2016
46
Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis. ( 27605399 )
2016
47
Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. ( 27629373 )
2016
48
Alarmin high mobility group box-1 in maternal serum as a potential biomarker of chorioamnionitis-associated preterm birth. ( 27684473 )
2016
49
Histological Chorioamnionitis. ( 28856130 )
2016
50
Chorioamnionitis and Neurocognitive Development at Age 2 Years. ( 26855093 )
2016

Variations for Chorioamnionitis

Expression for Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for Chorioamnionitis

Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL2 CRP CXCL8 ELANE IL1A IL1B
2
Show member pathways
13.82 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
3
Show member pathways
13.69 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
4
Show member pathways
13.57 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
5
Show member pathways
13.45 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
6
Show member pathways
13.41 CCL2 CXCL8 IL1A IL1B IL1R1 IL6
7
Show member pathways
13.36 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
8
Show member pathways
13 CCL2 CXCL8 IL1A IL1B IL1R1 IL6
9
Show member pathways
12.88 CXCL8 IL1A IL1B IL6 TNF
10
Show member pathways
12.87 CCL2 CXCL8 IL1A IL1B IL6 TLR4
11 12.8 FLT1 IL1A IL1B IL1R1 TNF
12
Show member pathways
12.76 FLT1 IL1A IL1B IL1R1 IL6 TLR4
13
Show member pathways
12.71 FLT1 IL1A IL1B IL1R1 TLR4 TNF
14
Show member pathways
12.68 IL1A IL1B IL1R1 IL6 TLR4 TNF
15
Show member pathways
12.66 IL1A IL1B IL1R1 TNF
16
Show member pathways
12.64 CXCL8 IL6 MMP9 TLR4 TNF
17
Show member pathways
12.63 CCL2 CXCL8 IL1B IL6 TLR4 TNF
18
Show member pathways
12.59 CCL2 IL1B IL6 TNF
19
Show member pathways
12.47 FLT1 IL1A IL1B IL1R1
20
Show member pathways
12.46 IL1A IL1B IL6 TNF
21
Show member pathways
12.43 CCL2 CRP IL1B IL6 TNF
22
Show member pathways
12.41 CCL2 CXCL8 IL1B IL6 MMP9 TNF
23
Show member pathways
12.36 CXCL8 IL1A IL6 TLR4 TNF
24
Show member pathways
12.35 CCL2 IL1A IL1B IL1R1
25 12.35 CXCL8 ELANE FLT1 IL6 MMP9
26 12.33 IL1A IL1B IL6 TLR4 TNF
27
Show member pathways
12.31 IL1A IL1B TLR4 TNF
28 12.29 CXCL8 IL1A IL1B IL6 TNF
29
Show member pathways
12.28 IL1A IL1B TLR4 TNF
30
Show member pathways
12.27 CXCL8 IL1A IL1B IL1R1 IL6 TLR4
31 12.25 IL6 MMP9 TLR4 TNF
32
Show member pathways
12.25 CXCL8 IL1A IL1B IL6 TNF
33
Show member pathways
12.24 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
34 12.14 CCL2 IL1A IL1B IL1R1 MMP9 TNF
35 12.13 IL1A IL1B IL1R1 TNF
36
Show member pathways
12.11 IL1A IL1B IL1R1 TLR4
37 12.06 CCL2 IL1B IL6 MMP9 TNF
38 12.04 CXCL8 IL1A IL1B IL6
39
Show member pathways
12.03 IL1B IL6 TLR4 TNF
40
Show member pathways
12 ELANE MMP8 MMP9 TNF
41 12 IL1A IL1B IL1R1 IL6 TNF
42 11.99 CXCL8 IL1B IL1R1 TLR4 TNF
43 11.98 CCL2 CXCL8 IL1A IL1B IL6 TNF
44
Show member pathways
11.96 IL1B IL1R1 IL6 TLR4
45 11.94 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
46 11.93 FLT1 IL6 TLR4
47 11.92 CXCL8 IL1A IL1B IL6 TLR4
48
Show member pathways
11.9 CXCL8 IL6 TLR4
49 11.87 CCL2 FLT1 MMP9
50 11.86 CCL2 CXCL8 IL1A IL1B IL6 MMP9

GO Terms for Chorioamnionitis

Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CCL2 CRP CXCL8 ELANE FLT1 IL1A
2 extracellular region GO:0005576 9.44 CCL2 CRP CXCL8 ELANE FLT1 IL1A
3 secretory granule GO:0030141 9.33 ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 CRP IL1A IL1B IL6 TLR4 TNF
2 leukocyte migration GO:0050900 9.94 ELANE IL1B MMP9 TNF
3 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.88 IL1B IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.87 CRP IL6 TNF
6 extracellular matrix disassembly GO:0022617 9.86 ELANE MMP8 MMP9
7 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
8 regulation of inflammatory response GO:0050727 9.85 IL1R1 TLR4 TNF
9 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR4 TNF
11 cytokine-mediated signaling pathway GO:0019221 9.85 CCL2 IL1A IL1B IL1R1 IL6
12 positive regulation of angiogenesis GO:0045766 9.84 CXCL8 FLT1 IL1A IL1B
13 neutrophil chemotaxis GO:0030593 9.83 CCL2 CXCL8 IL1B
14 response to glucocorticoid GO:0051384 9.83 IL6 OXT TNF
15 positive regulation of MAP kinase activity GO:0043406 9.82 ELANE FLT1 TNF
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 ELANE IL6 TNF
17 humoral immune response GO:0006959 9.81 CCL2 IL6 TNF
18 regulation of receptor activity GO:0010469 9.8 CCL2 CXCL8 IL1A IL1B IL6 OXT
19 protein kinase B signaling GO:0043491 9.79 CCL2 IL1B TNF
20 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B TLR4 TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B TLR4 TNF
22 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 CXCL8 IL6 TLR4 TNF
23 monocyte chemotaxis GO:0002548 9.76 CCL2 FLT1 IL6
24 immune response GO:0006955 9.76 CCL2 CXCL8 IL1A IL1B IL1R1 IL6
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 IL1A IL1B TNF
26 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
28 interleukin-1-mediated signaling pathway GO:0070498 9.71 IL1A IL1R1
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
30 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.71 FLT1 IL1B
31 negative regulation of growth of symbiont in host GO:0044130 9.71 ELANE TNF
32 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 CCL2 TLR4
34 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B TLR4 TNF
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
36 PERK-mediated unfolded protein response GO:0036499 9.69 CCL2 CXCL8
37 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.69 IL1A IL1B
38 positive regulation of NF-kappaB import into nucleus GO:0042346 9.69 IL1B TLR4 TNF
39 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.68 IL1A IL1B
40 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
41 positive regulation of prostaglandin secretion GO:0032308 9.67 IL1B OXT
42 positive regulation of chemokine production GO:0032722 9.67 IL6 TLR4 TNF
43 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
44 ectopic germ cell programmed cell death GO:0035234 9.66 IL1A IL1B
45 fever generation GO:0001660 9.63 IL1A IL1B
46 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
47 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 CCL2 IL1B TLR4 TNF
48 positive regulation of neutrophil extravasation GO:2000391 9.61 IL1A IL1R1
49 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
50 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1A IL1B
2 protease binding GO:0002020 9.13 ELANE IL1R1 TNF
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL1A IL1B IL6 TNF

Sources for Chorioamnionitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
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50 NINDS
51 Novoseek
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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