Aliases & Classifications for Chorioamnionitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS
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Chorioamnionitis, Aliases & Descriptions:

Name: Chorioamnionitis 9 11 43 60


External Ids:

Disease Ontology9 DOID:0050697

Summaries for Chorioamnionitis

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Disease Ontology:9 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary: Chorioamnionitis is related to funisitis and bronchopulmonary dysplasia. An important gene associated with Chorioamnionitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and Selected targets of C EBPalpha. The compounds sivelestat and survanta have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:63 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1funisitis31.7MMP8
2bronchopulmonary dysplasia31.1ELANE, IL8
3bacteriuria30.6CRP
4crohn's disease30.4CRP
5arthritis30.0IL8, IL6, IL1B
6malaria29.9IL1R1, IL1B
7respiratory failure29.9CRP, IL1B, IL6
8asthma29.8MMP8, IL8, IL1B, ELANE
9bacterial vaginosis29.8IL1B, IL8, IL1R1
10pneumonia29.2IL1B, MMP8, ELANE, CRP, IL8, IL6
11endometriosis29.1IL1B, OXTR, IL6, IL1R1, IL8
12bronchiolitis10.5IL8
13capillary leak syndrome10.5ELANE
14common cold10.5IL8
15vaginitis10.5
16pustulosis palmaris et plantaris10.5ELANE
17cerebritis10.4
18aortic aneurysm10.4CRP
19adult-onset still's disease10.4CRP
20brain injury10.4
21cerebral palsy10.4
22intervertebral disc disease10.4IL1B
23bronchiolitis obliterans10.3MMP8, IL8
24endotheliitis10.3
25chronic ulcer of skin10.3ELANE, MMP8
26pulmonary emphysema10.3MMP8, ELANE
27schnitzler syndrome10.3IL1R1
28abdominal aortic aneurysm10.3MMP8, ELANE
29extrinsic allergic alveolitis10.3IL8, ELANE
30myasthenic syndrome, slow-channel congenital10.3CRP, IL8
31bronchitis10.3ELANE, IL8
32reactive arthritis10.3MMP8, CRP
33preterm premature rupture of the membranes10.2
34cervicitis10.2
35endometritis10.2
36candida glabrata10.2
37skin disease10.2IL1B, IL6
38euthyroid sick syndrome10.2IL1B, IL6
39mastitis10.2IL8, IL1B
40aneurysm10.2MMP8, ELANE
41poems syndrome10.2IL6, IL1B
42kawasaki disease10.2ELANE, CRP
43cork-handlers' disease10.2IL8, ELANE
44behcet's disease10.2IL8, CRP
45bronchiectasis10.2IL8, ELANE, MMP8
46bacteremia10.2
47leukemoid reaction10.2
48eclampsia10.2
49pre-eclampsia10.2
50familial mediterranean fever, ar10.2CRP, IL1B

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to chorioamnionitis

Symptoms for Chorioamnionitis

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Drugs & Therapeutics for Chorioamnionitis

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Drug clinical trials:

Search ClinicalTrials for Chorioamnionitis

Search NIH Clinical Center for Chorioamnionitis

Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

31
Placenta, Uterus, Lung, Brain, Colon, Endothelial, Neutrophil, Monocytes, Fetal lung, Thymus, Heart, T cells, Fetal brain, Bone marrow, Bone, Spleen, Skin, Testes

Animal Models for Chorioamnionitis or affiliated genes

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MGI Mouse Phenotypes related to Chorioamnionitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MMP8, ELANE, IL1R1, IL6, IL1B
2MP:00053977.9IL1B, IL6, IL8, IL1R1, ELANE
3MP:00053857.5IL1R1, IL6, IL1B, HPGD, CRP
4MP:00053767.3ELANE, IL1R1, IL6, IL1B, HPGD, CRP
5MP:00053877.1CRP, IL1B, IL6, IL8, IL1R1, ELANE

Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Protective ventilation of preterm lambs exposed to acute chorioamnionitis does not reduce ventilation-induced lung or brain injury. (25379714)
2014
2
Silent chorioamnionitis and associated pregnancy outcomes: a review of clinical data gathered over a 16-year period. (24421211)
2014
3
Association of respiratory distress syndrome and perinatal hypoxia with histologic chorioamnionitis in preterm infants. (24827948)
2014
4
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
5
Histological chorioamnionitis: effects on premature delivery and neonatal prognosis. (23639744)
2013
6
Histological chorioamnionitis associated with preterm prelabour rupture of membranes at kingston general hospital: a practice audit. (24405875)
2013
7
Chorioamnionitis and chronic lung disease of prematurity: a path analysis of causality. (22147641)
2012
8
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
9
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
10
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
11
Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. (21860336)
2012
12
A clinical prediction rule for histological chorioamnionitis in preterm newborns. (23071549)
2012
13
Limited course of antibiotic treatment for chorioamnionitis. (22617573)
2012
14
Severity of chorioamnionitis and neonatal outcome. (21535310)
2011
15
Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. (20961565)
2011
16
Chorioamnionitis - new ideas from experimental models. (21701204)
2011
17
Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis. (21784405)
2011
18
Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. (20717072)
2010
19
Chorioamnionitis alters the response to surfactant in preterm infants. (19833352)
2010
20
Maternal interleukin-6 (-174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant. (20237486)
2010
21
Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery. (19858776)
2010
22
Chorioamnionitis and intrauterine fetal death after second-trimester amniocentesis. (19893298)
2009
23
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. (19164476)
2009
24
Effect of chorioamnionitis on brain development and injury in premature newborns. (19743455)
2009
25
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
26
Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis. (18032912)
2008
27
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. (17940116)
2008
28
Chorioamnionitis and increased galectin-1 expression in PPROM --an anti-inflammatory response in the fetal membranes? (18691335)
2008
29
The association between meconium-stained amniotic fluid and chorioamnionitis or endometritis. (17427518)
2007
30
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. (17567416)
2007
31
Maternal signs of chorioamnionitis: persistent cognitive impairment in low-birthweight children. (16449032)
2006
32
Chorioamnionitis-induced changes of fetal extramedullar hematopoiesis in the second trimester of gestation. Is diagnosis from fetal autopsy possible? (15583932)
2005
33
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. (15746262)
2005
34
Early postnatal changes in the perfusion index in term newborns with subclinical chorioamnionitis. (15863488)
2005
35
Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitis. (15241686)
2004
36
Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies. (14711859)
2004
37
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
38
Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. (14600137)
2003
39
Induction of hepatic granulopoiesis due to chorioamnionitis during the second trimester of development. (12969577)
2003
40
Chorioamnionitis and cerebral palsy in term and near-term infants. (14645309)
2003
41
Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis. (12565880)
2003
42
Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. (12530486)
2002
43
Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. (12066943)
2002
44
Maternal serum C-reactive protein level does not change significantly after fetal reduction: it could be used as an indicator of chorioamnionitis. (11495410)
2001
45
Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. (10960621)
2000
46
Candida chorioamnionitis after serial therapeutic amniocenteses: a possible association. (10920796)
2000
47
Chorioamnionitis and endometritis. (9067792)
1997
48
Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants. (8629898)
1996
49
Maternal and umbilical cord serum interleukin levels in preterm labor with clinical chorioamnionitis. (8178864)
1994
50
Chorioamnionitis and serum IgM in Wilson-Mikity syndrome. (2589873)
1989

Variations for Chorioamnionitis

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Expression for genes affiliated with Chorioamnionitis

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Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for genes affiliated with Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ELANE, MMP8
29.6IL6, IL8
39.6IL6, IL8
49.6IL8, IL6
59.6IL8, IL6
6
Show member pathways
9.6IL8, IL6
79.6IL6, ELANE
89.5CRP, IL6
99.5IL1B, IL6
109.5IL1B, IL6
119.5IL6, IL1B
12
Show member pathways
IL27-mediated signaling events36
9.5IL1B, IL6
139.5IL6, IL1B
149.5IL1B, IL6
15
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.1IL1R1, IL1B
16
Show member pathways
Serotonin Transporter Activity36
9.1IL1R1, IL1B
179.1IL1B, IL6, IL8
189.1IL1B, IL6, IL8
19
Show member pathways
9.1IL6, IL1B, IL8
20
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1IL1B, IL8, IL6
219.1IL1B, IL8, IL6
229.1IL1B, IL6, IL8
239.1IL6, IL1B, IL8
24
Show member pathways
9.1IL8, IL6, IL1B
25
Show member pathways
9.1IL8, IL1B, IL6
269.1IL8, IL6, IL1B
27
Show member pathways
9.1IL8, IL1B, IL6
289.1IL8, IL6, IL1B
29
Show member pathways
thioredoxin pathway36
9.0IL6, CRP, IL1B
308.9ELANE, HPGD, IL6, IL8
31
Show member pathways
Calcium Regulation in the Cardiac Cell36
8.9OXTR, IL6, IL1B
328.8IL1R1, IL1B, IL8
33
Show member pathways
8.7IL1R1, IL6, IL1B
34
Show member pathways
8.7IL1B, IL6, IL1R1
35
Show member pathways
8.7IL1R1, IL1B, IL6
36
Show member pathways
8.7IL6, IL1B, IL1R1
378.7IL1B, IL6, IL1R1
38
Show member pathways
8.3IL6, IL1B, IL8, IL1R1
39
Show member pathways
Immune response MIF in innate immunity response58
8.3IL1B, IL6, IL8, IL1R1
40
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.3IL1B, IL6, IL8, IL1R1
41
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.3IL1B, IL6, IL8, IL1R1
428.3IL1B, IL6, IL8, IL1R1
43
Show member pathways
8.3IL6, IL1R1, IL1B, IL8
44
Show member pathways
8.3IL1R1, IL8, IL1B, IL6
45
Show member pathways
8.3IL6, IL8, IL1R1, IL1B
468.3IL1R1, IL8, IL1B, IL6
47
Show member pathways
8.3IL8, IL1R1, IL6, IL1B

Compounds for genes affiliated with Chorioamnionitis

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Compounds related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1sivelestat439.6IL6, IL8, ELANE
2survanta439.6IL1B, ELANE, IL8
3tlck439.5IL8, ELANE, IL1B
4ulinastatin439.4ELANE, IL8, IL6
5turpentine439.4CRP, IL1B, IL6
6taurine chloramine439.4IL6, IL8, IL1B
7bucillamine439.3CRP, IL1B, IL6
8hbd2439.3IL1B, IL8, IL6
9mip 1alpha439.2IL1B, IL8, IL6
10ciglitazone43 2810.2IL1B, HPGD, IL6, IL8
11gabexate mesilate439.1CRP, IL6, IL8, ELANE
12anaphylatoxin439.1IL6, IL8, ELANE, IL1B
13tpck439.1IL1B, IL8, IL6
14gm-csf43 2810.1IL1B, IL8, ELANE, IL6
15clodronate43 49 1211.1IL1B, IL6, MMP8
16monosodium urate439.0IL1B, IL1R1, IL8
17gold sodium thiomalate438.8IL8, IL1B, IL1R1
18il-12438.7IL1R1, IL8, IL1B, IL6
19lipoteichoic acid438.7IL6, IL1R1, IL8, IL1B
20il 10438.7IL6, IL1R1, IL1B, IL8
21peptidoglycan43 289.7IL1B, IL1R1, IL8, IL6
22ccl343 289.6IL8, IL1R1, IL6, IL1B
23sulfasalazine28 43 49 1211.6IL8, IL1B, IL1R1, CRP
24polysulfone438.6ELANE, IL1R1, IL1B, CRP
25anakinra43 129.6IL6, IL1R1, CRP, IL1B
26infliximab43 49 1210.5IL1R1, IL6, CRP, IL1B
27ivig438.5CRP, IL1B, IL6, IL1R1
28adalimumab43 49 1210.4IL6, CRP, IL1R1
29pentoxifylline43 129.3IL1B, IL6, IL8, IL1R1, ELANE
30hydrocortisone43 2 59 1211.3IL1R1, IL8, ELANE, IL1B, IL6
31hyaluronic acid43 249.3IL1B, ELANE, IL8, IL1R1, IL6
32etanercept43 49 1210.2IL6, IL1R1, IL8, IL1B, CRP
33mifepristone43 28 59 1211.2IL1B, IL8, IL1R1, OXTR, HPGD
34fibrinogen438.2IL6, MMP8, IL1R1, ELANE, CRP
35tenidap43 289.2ELANE, IL1R1, IL1B, CRP, IL6
36n acetylcysteine438.1CRP, IL6, IL1B, IL1R1, IL8
37cyclosporin a43 28 5910.1IL1R1, ELANE, MMP8, IL8, IL6
38prostaglandin438.1HPGD, IL1R1, IL6, IL1B, OXTR
39sb 20358043 599.1CRP, IL1B, IL1R1, IL6, IL8
40indomethacin43 28 59 1211.0IL1B, HPGD, OXTR, IL1R1, IL6
41leukotriene b443 59 2410.0IL6, IL1B, IL1R1, ELANE, HPGD, IL8
42lactate438.0CRP, IL6, IL8, MMP8, ELANE, IL1R1
43neopterin437.8IL1R1, ELANE, IL8, IL6, IL1B, CRP
44testosterone43 59 24 1210.6HPGD, ELANE, CRP, IL1R1, IL6, OXTR
45dexamethasone43 49 28 1210.6IL1B, IL6, IL1R1, OXTR, IL8, HPGD
46nitric oxide43 24 129.6IL8, MMP8, IL1R1, IL1B, OXTR, IL6
47alanine437.5CRP, MMP8, OXTR, HPGD, IL6, IL1R1
48endotoxin437.5HPGD, IL6, CRP, IL1B, IL8, IL1R1
49vegf437.3CRP, IL6, MMP8, OXTR, IL1R1, IL8
50pge2437.0IL1R1, HPGD, IL1B, IL6, IL8, MMP8

GO Terms for genes affiliated with Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3CRP, IL1B, IL6, IL8, MMP8
2extracellular regionGO:00055766.7CRP, MMP8, ELANE, IL1R1, IL8, IL6

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:00450799.9IL6, ELANE
2negative regulation of lipid storageGO:00108889.7IL6, CRP
3positive regulation of nitric oxide biosynthetic processGO:00454299.7IL1B, IL6
4neutrophil chemotaxisGO:00305939.7IL8, IL1B
5defense response to Gram-positive bacteriumGO:00508309.7CRP, IL6
6acute-phase responseGO:00069539.6CRP, IL6
7positive regulation of smooth muscle cell proliferationGO:00486619.6IL6, ELANE
8positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6
9positive regulation of T cell proliferationGO:00421029.2IL1B, IL6
10negative regulation of cell proliferationGO:00082859.1IL1B, IL6, IL8
11inflammatory responseGO:00069548.8CRP, IL1B, IL6, IL8
12immune responseGO:00069558.7IL1R1, IL8, IL1B

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.2IL1R1, ELANE

Products for genes affiliated with Chorioamnionitis

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Sources for Chorioamnionitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet