MCID: CHR005
MIFTS: 50

Chorioamnionitis malady

Fetal diseases category

Summaries for Chorioamnionitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards: Chorioamnionitis is related to funisitis and bronchopulmonary dysplasia. An important gene associated with Chorioamnionitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Selected targets of C EBPalpha and Matrix Metalloproteinases. The compounds sivelestat and survanta have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:66 Chorioamnionitis is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial... more...

Aliases & Classifications for Chorioamnionitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

chorioamnionitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:0050697

Related Diseases for Chorioamnionitis

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18GeneCards, 19GeneDecks
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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1funisitis31.1MMP8
2bronchopulmonary dysplasia30.7ELANE, IL8
3sepsis30.6ELANE, IL1R1, IL8, IL6, CRP, IL1B
4bacteriuria30.1CRP
5crohn's disease30.0CRP
6respiratory failure29.9CRP, IL1B, IL6
7asthma29.9MMP8, IL8, IL1B, ELANE
8bacterial vaginosis29.9IL1B, IL8, IL1R1
9pneumonia29.7IL1B, MMP8, ELANE, CRP, IL8, IL6
10endometriosis29.7IL1B, OXTR, IL6, IL1R1, IL8
11cerebritis10.4
12cerebral palsy10.4
13vaginitis10.4
14brain injury10.4
15endotheliitis10.3
16cervicitis10.2
17endometritis10.2
18placental abruption10.2
19eclampsia10.2
20pre-eclampsia10.2
21candida glabrata10.2
22bacteremia10.2
23preterm premature rupture of the membranes10.2
24bronchiolitis10.1IL8
25capillary leak syndrome10.1ELANE
26common cold10.1IL8
27pustulosis palmaris et plantaris10.1ELANE
28aortic aneurysm10.1CRP
29adult-onset still's disease10.1CRP
30degenerative disc disease10.1IL1B
31appendicitis10.1
32leukemoid reaction10.1
33hepatitis10.1
34twin twin transfusion syndrome10.1
35hiv-110.1
36bronchiolitis obliterans10.1MMP8, IL8
37pulmonary emphysema10.1MMP8, ELANE
38schnitzler syndrome10.1IL1R1
39abdominal aortic aneurysm10.1MMP8, ELANE
40extrinsic allergic alveolitis10.1IL8, ELANE
41slow-channel congenital myasthenic syndrome10.1CRP, IL8
42bronchitis10.1ELANE, IL8
43reactive arthritis10.1MMP8, CRP
44skin disease10.1IL1B, IL6
45euthyroid sick syndrome10.1IL1B, IL6
46mastitis10.1IL8, IL1B
47poems syndrome10.0IL6, IL1B
48kawasaki disease10.0ELANE, CRP
49aneurysm10.0MMP8, ELANE
50cork-handlers' disease10.0IL8, ELANE

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to chorioamnionitis

Symptoms for Chorioamnionitis

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Drugs & Therapeutics for Chorioamnionitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chorioamnionitis

Drug clinical trials:

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Search NIH Clinical Center for Chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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34MalaCards
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MalaCards organs/tissues related to Chorioamnionitis:

34
Placenta, Uterus, Lung, Brain, Colon, Endothelial, Fetal lung, Monocytes, Thymus, Heart, Fetal brain, T cells, Testes, Skin, Spleen, Bone, Bone marrow

Animal Models for Chorioamnionitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chorioamnionitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MMP8, ELANE, IL1R1, IL6, IL1B
2MP:00053977.9IL1B, IL6, IL8, IL1R1, ELANE
3MP:00053857.5IL1R1, IL6, IL1B, HPGD, CRP
4MP:00053767.3ELANE, IL1R1, IL6, IL1B, HPGD, CRP
5MP:00053877.1CRP, IL1B, IL6, IL8, IL1R1, ELANE

Publications for Chorioamnionitis

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53PubMed
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Articles related to Chorioamnionitis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Silent chorioamnionitis and associated pregnancy outcomes: a review of clinical data gathered over a 16-year period. (24421211)
2014
2
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
3
Histological chorioamnionitis: effects on premature delivery and neonatal prognosis. (23639744)
2013
4
Histological chorioamnionitis associated with preterm prelabour rupture of membranes at kingston general hospital: a practice audit. (24405875)
2013
5
Chorioamnionitis and chronic lung disease of prematurity: a path analysis of causality. (22147641)
2012
6
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
7
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
8
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
9
Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. (21860336)
2012
10
A clinical prediction rule for histological chorioamnionitis in preterm newborns. (23071549)
2012
11
Limited course of antibiotic treatment for chorioamnionitis. (22617573)
2012
12
Severity of chorioamnionitis and neonatal outcome. (21535310)
2011
13
Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. (20961565)
2011
14
Chorioamnionitis - new ideas from experimental models. (21701204)
2011
15
Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis. (21784405)
2011
16
Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis. (21106714)
2011
17
Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis. (21933102)
2011
18
Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. (20717072)
2010
19
Chorioamnionitis alters the response to surfactant in preterm infants. (19833352)
2010
20
Maternal interleukin-6 (-174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant. (20237486)
2010
21
Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery. (19858776)
2010
22
Chorioamnionitis and intrauterine fetal death after second-trimester amniocentesis. (19893298)
2009
23
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. (19164476)
2009
24
Effect of chorioamnionitis on brain development and injury in premature newborns. (19743455)
2009
25
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
26
Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis. (18032912)
2008
27
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. (17940116)
2008
28
Chorioamnionitis and increased galectin-1 expression in PPROM --an anti-inflammatory response in the fetal membranes? (18691335)
2008
29
The association between meconium-stained amniotic fluid and chorioamnionitis or endometritis. (17427518)
2007
30
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. (17567416)
2007
31
Maternal signs of chorioamnionitis: persistent cognitive impairment in low-birthweight children. (16449032)
2006
32
Chorioamnionitis-induced changes of fetal extramedullar hematopoiesis in the second trimester of gestation. Is diagnosis from fetal autopsy possible? (15583932)
2005
33
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. (15746262)
2005
34
Early postnatal changes in the perfusion index in term newborns with subclinical chorioamnionitis. (15863488)
2005
35
Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitis. (15241686)
2004
36
Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies. (14711859)
2004
37
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
38
Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. (14600137)
2003
39
Induction of hepatic granulopoiesis due to chorioamnionitis during the second trimester of development. (12969577)
2003
40
Chorioamnionitis and cerebral palsy in term and near-term infants. (14645309)
2003
41
Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis. (12565880)
2003
42
Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. (12530486)
2002
43
Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. (12066943)
2002
44
Maternal serum C-reactive protein level does not change significantly after fetal reduction: it could be used as an indicator of chorioamnionitis. (11495410)
2001
45
Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. (10960621)
2000
46
Candida chorioamnionitis after serial therapeutic amniocenteses: a possible association. (10920796)
2000
47
Chorioamnionitis and endometritis. (9067792)
1997
48
Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants. (8629898)
1996
49
Maternal and umbilical cord serum interleukin levels in preterm labor with clinical chorioamnionitis. (8178864)
1994
50
Chorioamnionitis and serum IgM in Wilson-Mikity syndrome. (2589873)
1989

Variations for Chorioamnionitis

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Expression for genes affiliated with Chorioamnionitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for genes affiliated with Chorioamnionitis

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters, 31KEGG, 55R&D Systems
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Pathways related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP8, ELANE
2
Show member pathways
9.7MMP8, ELANE
39.6IL6, IL8
4
Show member pathways
9.6IL8, IL6
59.6IL8, IL6
69.6IL8, IL6
79.6IL8, IL6
89.6IL6, ELANE
99.5CRP, IL6
109.5IL1B, IL6
119.5IL1B, IL6
129.5IL6, IL1B
139.5IL6, IL1B
149.5IL1B, IL6
15
Show member pathways
IL27-mediated signaling events39
9.5IL6, IL1B
169.4ELANE, OXTR
17
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.1IL1R1, IL1B
18
Show member pathways
Serotonin Transporter Activity39
9.1IL1B, IL1R1
19
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1IL1B, IL6, IL8
209.1IL1B, IL6, IL8
219.1IL1B, IL6, IL8
229.1IL1B, IL6, IL8
23
Show member pathways
9.1IL1B, IL6, IL8
24
Show member pathways
9.1IL1B, IL6, IL8
259.1IL1B, IL6, IL8
26
Show member pathways
9.1IL1B, IL6, IL8
279.1IL8, IL6, IL1B
289.1IL8, IL6, IL1B
299.1IL8, IL6, IL1B
309.1IL8, IL6, IL1B
31
Show member pathways
9.1IL8, IL6, IL1B
32
Show member pathways
thioredoxin pathway39
9.0IL6, IL1B, CRP
338.9ELANE, IL8, IL6, HPGD
34
Show member pathways
Calcium Regulation in the Cardiac Cell39
8.9IL1B, IL6, OXTR
358.8IL1R1, IL8, IL1B
36
Show member pathways
8.7IL1B, IL6, IL1R1
37
Show member pathways
8.7IL1R1, IL6, IL1B
38
Show member pathways
8.7IL1B, IL6, IL1R1
39
Show member pathways
8.7IL1R1, IL6, IL1B
408.7IL1R1, IL6, IL1B
41
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.3IL1B, IL6, IL8, IL1R1
428.3IL1B, IL6, IL8, IL1R1
43
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
448.3IL1R1, IL8, IL6, IL1B
45
Show member pathways
Immune response MIF in innate immunity response61
8.3IL1R1, IL8, IL6, IL1B
46
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.3IL1R1, IL8, IL6, IL1B
47
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
48
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
49
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
50
Show member pathways
8.3IL1R1, IL8, IL6, IL1B

Compounds for genes affiliated with Chorioamnionitis

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 25HMDB
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Compounds related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1sivelestat469.6IL6, IL8, ELANE
2survanta469.6IL1B, ELANE, IL8
3tlck469.5IL8, ELANE, IL1B
4ulinastatin469.4ELANE, IL8, IL6
5turpentine469.4CRP, IL1B, IL6
6taurine chloramine469.4IL6, IL8, IL1B
7bucillamine469.3CRP, IL1B, IL6
8hbd2469.3IL1B, IL8, IL6
9mip 1alpha469.2IL1B, IL8, IL6
10ciglitazone46 3010.2IL1B, HPGD, IL6, IL8
11gabexate mesilate469.1CRP, IL6, IL8, ELANE
12anaphylatoxin469.1IL6, IL8, ELANE, IL1B
13tpck469.1IL1B, IL8, IL6
14gm-csf46 3010.1IL1B, IL8, ELANE, IL6
15clodronate46 52 1211.1IL1B, IL6, MMP8
16monosodium urate469.0IL1B, IL1R1, IL8
17gold sodium thiomalate468.8IL8, IL1B, IL1R1
18il-12468.7IL1R1, IL8, IL1B, IL6
19lipoteichoic acid468.7IL6, IL1R1, IL8, IL1B
20il 10468.7IL6, IL1R1, IL1B, IL8
21peptidoglycan46 309.7IL1B, IL1R1, IL8, IL6
22ccl346 309.6IL8, IL1R1, IL6, IL1B
23sulfasalazine30 46 52 1211.6IL8, IL1B, IL1R1, CRP
24polysulfone468.6ELANE, IL1R1, IL1B, CRP
25anakinra46 129.6IL6, IL1R1, CRP, IL1B
26infliximab46 52 1210.5IL1R1, IL6, CRP, IL1B
27ivig468.5CRP, IL1B, IL6, IL1R1
28adalimumab46 52 1210.4IL6, CRP, IL1R1
29pentoxifylline46 129.3IL1B, IL6, IL8, IL1R1, ELANE
30hydrocortisone46 3 62 1211.3IL1R1, IL8, ELANE, IL1B, IL6
31hyaluronic acid46 259.3IL1B, ELANE, IL8, IL1R1, IL6
32etanercept46 52 1210.2IL6, IL1R1, IL8, IL1B, CRP
33mifepristone46 30 62 1211.2IL1B, IL8, IL1R1, OXTR, HPGD
34fibrinogen468.2IL6, MMP8, IL1R1, ELANE, CRP
35tenidap46 309.2ELANE, IL1R1, IL1B, CRP, IL6
36n acetylcysteine468.1CRP, IL6, IL1B, IL1R1, IL8
37cyclosporin a46 30 6210.1IL1R1, ELANE, MMP8, IL8, IL6
38prostaglandin468.1HPGD, IL1R1, IL6, IL1B, OXTR
39sb 20358046 629.1CRP, IL1B, IL1R1, IL6, IL8
40indomethacin46 30 62 1211.0IL1B, HPGD, OXTR, IL1R1, IL6
41leukotriene b446 62 2510.0IL6, IL1B, IL1R1, ELANE, HPGD, IL8
42lactate468.0CRP, IL6, IL8, MMP8, ELANE, IL1R1
43neopterin467.8IL1R1, ELANE, IL8, IL6, IL1B, CRP
44testosterone46 62 25 1210.6HPGD, ELANE, CRP, IL1R1, IL6, OXTR
45dexamethasone46 52 30 1210.6IL1B, IL6, IL1R1, OXTR, IL8, HPGD
46nitric oxide46 25 129.6IL8, MMP8, IL1R1, IL1B, OXTR, IL6
47alanine467.5CRP, MMP8, OXTR, HPGD, IL6, IL1R1
48endotoxin467.5HPGD, IL6, CRP, IL1B, IL8, IL1R1
49vegf467.3CRP, IL6, MMP8, OXTR, IL1R1, IL8
50pge2467.0IL1R1, HPGD, IL1B, IL6, IL8, MMP8

GO Terms for genes affiliated with Chorioamnionitis

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17Gene Ontology
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Cellular components related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3CRP, IL1B, IL6, IL8, MMP8
2extracellular regionGO:0055766.7CRP, MMP8, ELANE, IL1R1, IL8, IL6

Biological processes related to Chorioamnionitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:0450799.9IL6, ELANE
2negative regulation of lipid storageGO:0108889.7IL6, CRP
3positive regulation of nitric oxide biosynthetic processGO:0454299.7IL1B, IL6
4neutrophil chemotaxisGO:0305939.7IL8, IL1B
5defense response to Gram-positive bacteriumGO:0508309.7CRP, IL6
6acute-phase responseGO:0069539.6CRP, IL6
7positive regulation of smooth muscle cell proliferationGO:0486619.6IL6, ELANE
8positive regulation of interleukin-6 productionGO:0327559.6IL1B, IL6
9positive regulation of T cell proliferationGO:0421029.2IL1B, IL6
10negative regulation of cell proliferationGO:0082859.1IL1B, IL6, IL8
11inflammatory responseGO:0069548.8CRP, IL1B, IL6, IL8
12immune responseGO:0069558.7IL1R1, IL8, IL1B

Molecular functions related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2IL1R1, ELANE

Products for genes affiliated with Chorioamnionitis

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  • Antibodies
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Sources for Chorioamnionitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet