MCID: CHR005
MIFTS: 50

Chorioamnionitis malady

Fetal diseases category

Summaries for Chorioamnionitis

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Disease Ontology:9 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary: Chorioamnionitis is related to funisitis and bronchopulmonary dysplasia. An important gene associated with Chorioamnionitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Selected targets of C EBPalpha and Matrix Metalloproteinases. The compounds sivelestat and survanta have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:64 Chorioamnionitis is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial... more...

Aliases & Classifications for Chorioamnionitis

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS
See all sources

Chorioamnionitis, Aliases & Descriptions:

Name: Chorioamnionitis 9 11 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology9 DOID:0050697

Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1funisitis31.7MMP8
2bronchopulmonary dysplasia31.1ELANE, IL8
3bacteriuria30.6CRP
4crohn's disease30.4CRP
5arthritis30.0IL8, IL6, IL1B
6respiratory failure29.9CRP, IL1B, IL6
7sepsis29.9ELANE, IL1R1, IL8, IL6, CRP, IL1B
8asthma29.8MMP8, IL8, IL1B, ELANE
9bacterial vaginosis29.8IL1B, IL8, IL1R1
10pneumonia29.2IL1B, MMP8, ELANE, CRP, IL8, IL6
11endometriosis29.1IL1B, OXTR, IL6, IL1R1, IL8
12bronchiolitis10.5IL8
13capillary leak syndrome10.5ELANE
14common cold10.5IL8
15pustulosis palmaris et plantaris10.5ELANE
16aortic aneurysm10.4CRP
17cerebritis10.4
18vaginitis10.4
19adult-onset still's disease10.4CRP
20cerebral palsy10.4
21degenerative disc disease10.4IL1B
22brain injury10.4
23bronchiolitis obliterans10.3MMP8, IL8
24endotheliitis10.3
25pulmonary emphysema10.3MMP8, ELANE
26schnitzler syndrome10.3IL1R1
27abdominal aortic aneurysm10.3MMP8, ELANE
28extrinsic allergic alveolitis10.3IL8, ELANE
29slow-channel congenital myasthenic syndrome10.3CRP, IL8
30bronchitis10.3ELANE, IL8
31reactive arthritis10.3MMP8, CRP
32cervicitis10.2
33endometritis10.2
34preterm premature rupture of the membranes10.2
35skin disease10.2IL1B, IL6
36euthyroid sick syndrome10.2IL1B, IL6
37mastitis10.2IL8, IL1B
38poems syndrome10.2IL6, IL1B
39kawasaki disease10.2ELANE, CRP
40aneurysm10.2MMP8, ELANE
41cork-handlers' disease10.2IL8, ELANE
42bronchiectasis10.2IL8, ELANE, MMP8
43behcet's disease10.2IL8, CRP
44familial mediterranean fever10.2CRP, IL1B
45eclampsia10.2
46placental abruption10.2
47leukemoid reaction10.2
48pre-eclampsia10.2
49candida glabrata10.2
50bacteremia10.2

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to chorioamnionitis

Symptoms for Chorioamnionitis

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Drugs & Therapeutics for Chorioamnionitis

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Drug clinical trials:

Search ClinicalTrials for Chorioamnionitis

Search NIH Clinical Center for Chorioamnionitis

Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

32
Placenta, Uterus, Lung, Brain, Colon, Endothelial, Neutrophil, Monocytes, Fetal lung, Thymus, Heart, Fetal brain, Bone marrow, Bone, Spleen, Skin, Testes, T cells

Animal Models for Chorioamnionitis or affiliated genes

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MGI Mouse Phenotypes related to Chorioamnionitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MMP8, ELANE, IL1R1, IL6, IL1B
2MP:00053977.9IL1B, IL6, IL8, IL1R1, ELANE
3MP:00053857.5IL1R1, IL6, IL1B, HPGD, CRP
4MP:00053767.3ELANE, IL1R1, IL6, IL1B, HPGD, CRP
5MP:00053877.1CRP, IL1B, IL6, IL8, IL1R1, ELANE

Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Silent chorioamnionitis and associated pregnancy outcomes: a review of clinical data gathered over a 16-year period. (24421211)
2014
2
Association of respiratory distress syndrome and perinatal hypoxia with histologic chorioamnionitis in preterm infants. (24827948)
2014
3
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
4
Histological chorioamnionitis: effects on premature delivery and neonatal prognosis. (23639744)
2013
5
Histological chorioamnionitis associated with preterm prelabour rupture of membranes at kingston general hospital: a practice audit. (24405875)
2013
6
Chorioamnionitis and chronic lung disease of prematurity: a path analysis of causality. (22147641)
2012
7
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
8
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
9
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
10
Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis. (21860336)
2012
11
A clinical prediction rule for histological chorioamnionitis in preterm newborns. (23071549)
2012
12
Limited course of antibiotic treatment for chorioamnionitis. (22617573)
2012
13
Severity of chorioamnionitis and neonatal outcome. (21535310)
2011
14
Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. (20961565)
2011
15
Chorioamnionitis - new ideas from experimental models. (21701204)
2011
16
Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis. (21784405)
2011
17
Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis. (21106714)
2011
18
Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. (20717072)
2010
19
Chorioamnionitis alters the response to surfactant in preterm infants. (19833352)
2010
20
Maternal interleukin-6 (-174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant. (20237486)
2010
21
Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery. (19858776)
2010
22
Chorioamnionitis and intrauterine fetal death after second-trimester amniocentesis. (19893298)
2009
23
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. (19164476)
2009
24
Effect of chorioamnionitis on brain development and injury in premature newborns. (19743455)
2009
25
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
26
Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis. (18032912)
2008
27
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. (17940116)
2008
28
Chorioamnionitis and increased galectin-1 expression in PPROM --an anti-inflammatory response in the fetal membranes? (18691335)
2008
29
The association between meconium-stained amniotic fluid and chorioamnionitis or endometritis. (17427518)
2007
30
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. (17567416)
2007
31
Maternal signs of chorioamnionitis: persistent cognitive impairment in low-birthweight children. (16449032)
2006
32
Chorioamnionitis-induced changes of fetal extramedullar hematopoiesis in the second trimester of gestation. Is diagnosis from fetal autopsy possible? (15583932)
2005
33
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. (15746262)
2005
34
Early postnatal changes in the perfusion index in term newborns with subclinical chorioamnionitis. (15863488)
2005
35
Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitis. (15241686)
2004
36
Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies. (14711859)
2004
37
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
38
Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. (14600137)
2003
39
Induction of hepatic granulopoiesis due to chorioamnionitis during the second trimester of development. (12969577)
2003
40
Chorioamnionitis and cerebral palsy in term and near-term infants. (14645309)
2003
41
Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis. (12565880)
2003
42
Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. (12530486)
2002
43
Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. (12066943)
2002
44
Maternal serum C-reactive protein level does not change significantly after fetal reduction: it could be used as an indicator of chorioamnionitis. (11495410)
2001
45
Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. (10960621)
2000
46
Candida chorioamnionitis after serial therapeutic amniocenteses: a possible association. (10920796)
2000
47
Chorioamnionitis and endometritis. (9067792)
1997
48
Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants. (8629898)
1996
49
Maternal and umbilical cord serum interleukin levels in preterm labor with clinical chorioamnionitis. (8178864)
1994
50
Chorioamnionitis and serum IgM in Wilson-Mikity syndrome. (2589873)
1989

Variations for Chorioamnionitis

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Expression for genes affiliated with Chorioamnionitis

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Expression patterns in normal tissues for genes affiliated with Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for genes affiliated with Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP8, ELANE
2
Show member pathways
9.7MMP8, ELANE
39.6IL6, IL8
4
Show member pathways
9.6IL8, IL6
59.6IL8, IL6
69.6IL8, IL6
79.6IL8, IL6
89.6IL6, ELANE
99.5CRP, IL6
109.5IL1B, IL6
119.5IL1B, IL6
129.5IL6, IL1B
139.5IL6, IL1B
149.5IL1B, IL6
15
Show member pathways
IL27-mediated signaling events37
9.5IL6, IL1B
169.4ELANE, OXTR
17
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.1IL1R1, IL1B
18
Show member pathways
Serotonin Transporter Activity37
9.1IL1B, IL1R1
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1IL1B, IL6, IL8
209.1IL1B, IL6, IL8
219.1IL1B, IL6, IL8
229.1IL1B, IL6, IL8
23
Show member pathways
9.1IL1B, IL6, IL8
24
Show member pathways
9.1IL1B, IL6, IL8
259.1IL1B, IL6, IL8
26
Show member pathways
9.1IL1B, IL6, IL8
279.1IL8, IL6, IL1B
289.1IL8, IL6, IL1B
299.1IL8, IL6, IL1B
309.1IL8, IL6, IL1B
31
Show member pathways
9.1IL8, IL6, IL1B
32
Show member pathways
thioredoxin pathway37
9.0IL6, IL1B, CRP
338.9ELANE, IL8, IL6, HPGD
34
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.9IL1B, IL6, OXTR
358.8IL1R1, IL8, IL1B
36
Show member pathways
8.7IL1B, IL6, IL1R1
37
Show member pathways
8.7IL1R1, IL6, IL1B
38
Show member pathways
8.7IL1B, IL6, IL1R1
39
Show member pathways
8.7IL1R1, IL6, IL1B
408.7IL1R1, IL6, IL1B
41
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.3IL1B, IL6, IL8, IL1R1
428.3IL1B, IL6, IL8, IL1R1
43
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
448.3IL1R1, IL8, IL6, IL1B
45
Show member pathways
Immune response MIF in innate immunity response59
8.3IL1R1, IL8, IL6, IL1B
46
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.3IL1R1, IL8, IL6, IL1B
47
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
48
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
49
Show member pathways
8.3IL1R1, IL8, IL6, IL1B
50
Show member pathways
8.3IL1R1, IL8, IL6, IL1B

Compounds for genes affiliated with Chorioamnionitis

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Compounds related to Chorioamnionitis according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1sivelestat449.6IL6, IL8, ELANE
2survanta449.6IL1B, ELANE, IL8
3tlck449.5IL8, ELANE, IL1B
4ulinastatin449.4ELANE, IL8, IL6
5turpentine449.4CRP, IL1B, IL6
6taurine chloramine449.4IL6, IL8, IL1B
7bucillamine449.3CRP, IL1B, IL6
8hbd2449.3IL1B, IL8, IL6
9mip 1alpha449.2IL1B, IL8, IL6
10ciglitazone44 2910.2IL1B, HPGD, IL6, IL8
11gabexate mesilate449.1CRP, IL6, IL8, ELANE
12anaphylatoxin449.1IL6, IL8, ELANE, IL1B
13tpck449.1IL1B, IL8, IL6
14gm-csf44 2910.1IL1B, IL8, ELANE, IL6
15clodronate44 50 1211.1IL1B, IL6, MMP8
16monosodium urate449.0IL1B, IL1R1, IL8
17gold sodium thiomalate448.8IL8, IL1B, IL1R1
18il-12448.7IL1R1, IL8, IL1B, IL6
19lipoteichoic acid448.7IL6, IL1R1, IL8, IL1B
20il 10448.7IL6, IL1R1, IL1B, IL8
21peptidoglycan44 299.7IL1B, IL1R1, IL8, IL6
22ccl344 299.6IL8, IL1R1, IL6, IL1B
23sulfasalazine29 44 50 1211.6IL8, IL1B, IL1R1, CRP
24polysulfone448.6ELANE, IL1R1, IL1B, CRP
25anakinra44 129.6IL6, IL1R1, CRP, IL1B
26infliximab44 50 1210.5IL1R1, IL6, CRP, IL1B
27ivig448.5CRP, IL1B, IL6, IL1R1
28adalimumab44 50 1210.4IL6, CRP, IL1R1
29pentoxifylline44 129.3IL1B, IL6, IL8, IL1R1, ELANE
30hydrocortisone44 3 60 1211.3IL1R1, IL8, ELANE, IL1B, IL6
31hyaluronic acid44 259.3IL1B, ELANE, IL8, IL1R1, IL6
32etanercept44 50 1210.2IL6, IL1R1, IL8, IL1B, CRP
33mifepristone44 29 60 1211.2IL1B, IL8, IL1R1, OXTR, HPGD
34fibrinogen448.2IL6, MMP8, IL1R1, ELANE, CRP
35tenidap44 299.2ELANE, IL1R1, IL1B, CRP, IL6
36n acetylcysteine448.1CRP, IL6, IL1B, IL1R1, IL8
37cyclosporin a44 29 6010.1IL1R1, ELANE, MMP8, IL8, IL6
38prostaglandin448.1HPGD, IL1R1, IL6, IL1B, OXTR
39sb 20358044 609.1CRP, IL1B, IL1R1, IL6, IL8
40indomethacin44 29 60 1211.0IL1B, HPGD, OXTR, IL1R1, IL6
41leukotriene b444 60 2510.0IL6, IL1B, IL1R1, ELANE, HPGD, IL8
42lactate448.0CRP, IL6, IL8, MMP8, ELANE, IL1R1
43neopterin447.8IL1R1, ELANE, IL8, IL6, IL1B, CRP
44testosterone44 60 25 1210.6HPGD, ELANE, CRP, IL1R1, IL6, OXTR
45dexamethasone44 50 29 1210.6IL1B, IL6, IL1R1, OXTR, IL8, HPGD
46nitric oxide44 25 129.6IL8, MMP8, IL1R1, IL1B, OXTR, IL6
47alanine447.5CRP, MMP8, OXTR, HPGD, IL6, IL1R1
48endotoxin447.5HPGD, IL6, CRP, IL1B, IL8, IL1R1
49vegf447.3CRP, IL6, MMP8, OXTR, IL1R1, IL8
50pge2447.0IL1R1, HPGD, IL1B, IL6, IL8, MMP8

GO Terms for genes affiliated with Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3CRP, IL1B, IL6, IL8, MMP8
2extracellular regionGO:0055766.7CRP, MMP8, ELANE, IL1R1, IL8, IL6

Biological processes related to Chorioamnionitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:0450799.9IL6, ELANE
2negative regulation of lipid storageGO:0108889.7IL6, CRP
3positive regulation of nitric oxide biosynthetic processGO:0454299.7IL1B, IL6
4neutrophil chemotaxisGO:0305939.7IL8, IL1B
5defense response to Gram-positive bacteriumGO:0508309.7CRP, IL6
6acute-phase responseGO:0069539.6CRP, IL6
7positive regulation of smooth muscle cell proliferationGO:0486619.6IL6, ELANE
8positive regulation of interleukin-6 productionGO:0327559.6IL1B, IL6
9positive regulation of T cell proliferationGO:0421029.2IL1B, IL6
10negative regulation of cell proliferationGO:0082859.1IL1B, IL6, IL8
11inflammatory responseGO:0069548.8CRP, IL1B, IL6, IL8
12immune responseGO:0069558.7IL1R1, IL8, IL1B

Molecular functions related to Chorioamnionitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2IL1R1, ELANE

Products for genes affiliated with Chorioamnionitis

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Sources for Chorioamnionitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet