MCID: CHR074
MIFTS: 59

Choriocarcinoma malady

Summaries for Choriocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to gestational choriocarcinoma and adenocarcinoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Abacavir transport and metabolism and Folate biosynthesis. The drugs chlorambucil and vinblastine and the compounds testosterone and arginine have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Choriocarcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

choriocarcinoma 8 42 10 44 60
choriocarcinoma, no icd-o subtype 8
chorioepithelioma nos 8
chorioepithelioma 8


External Ids:

Disease Ontology8 DOID:3594
NCIt39 C2948
MeSH34 D002822

Related Diseases for Choriocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma31.4EBF4
2adenocarcinoma30.6EGF, CGB5, CGB7, CGB, AHR, ABCG2
3placental site trophoblastic tumor30.3CGB5, CGB
4breast cancer30.3EGF, AHR, CYP19A1, ERVW-1
5hepatitis30.3ALPP
6leukemia30.2EGF, CGB, AHR, ABCG2, SLC19A1, ERVW-1
7hyperthyroidism30.1CGB5, CGB, LEP, ALPP, ALPPL2
8hepatitis b30.1ALPPL2, ALPP, AHR, CGB
9squamous cell carcinoma30.0EGF, CGB7, CGB, AHR, HOPX, ABCG2
10testicular cancer30.0CGB5, CGB, ALPP, ALPPL2
11gonadoblastoma30.0ALPPL2, ALPP
12seminoma29.7CGB5, CGB7, CGB, ERVW-1, ALPP, ALPPL2
13endodermal sinus tumor29.7CGB5, CGB, ALPP, ALPPL2
14down syndrome29.7CGB5, CGB7, CGB, SLC19A1
15gestational trophoblastic neoplasm29.7CGB5, CGB7, CGB, ALPP
16hypertension29.7PPARG, LEP, SLC6A4, ENPEP
17endometriosis29.7CYP19A1, AHR
18leydig cell tumor29.7CYP19A1, CGB5
19melanoma29.7ABCG2, AHR, CGB
20endometrial carcinoma29.7CYP19A1, EGF
21pancreatitis29.7ALPPL2, ALPP
22leiomyoma29.7CYP19A1, EGF
23klinefelter's syndrome29.7CYP19A1, CGB
24placental choriocarcinoma10.8
25choriocarcinoma of ovary10.5
26choriocarcinoma of the testis10.5
27non-gestational choriocarcinoma10.5
28fallopian tube gestational choriocarcinoma10.3
29cervicitis10.3
30non-gestational ovarian choriocarcinoma10.3
31choroiditis10.3
32gestational ovarian choriocarcinoma10.3
33gastric adenocarcinoma10.3
34cerebritis10.2
35pineal region choriocarcinoma10.2
36mature teratoma10.2
37mediastinitis10.2
38pediatric cns choriocarcinoma10.1
39epithelioid trophoblastic tumor10.1
40childhood choriocarcinoma of the testis10.1
41duodenitis10.1
42vaginitis10.1
43testicular monophasic choriocarcinoma10.1
44adult central nervous system choriocarcinoma10.1
45pulmonary artery choriocarcinoma10.1
46childhood choriocarcinoma of the ovary10.1
47herpes gestationis10.1
48hepatitis a10.1
49pulmonary embolism10.1
50thyrotoxicosis10.1

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Clinical Features for Choriocarcinoma

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Drugs & Therapeutics for Choriocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Choriocarcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Choriocarcinoma

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Anatomical Context for Choriocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Choriocarcinoma:

32
Placenta, Ovary, Testis, Lung, Brain, Breast, Liver, Skin, Uterus, Colon, Cervix, Endothelial, Pituitary, Thyroid, Spinal cord, Pineal, Testes, Pancreas, Skeletal muscle, Spleen, Small intestine, Lymph node, Tonsil, Bone, Eye

Animal Models for Choriocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.1SLC19A1, ABCG2, LEP, CYP19A1, AHR, PPARG
2MP:001077110.8SLC19A1, SLC6A4, ABCG2, AHR
3MP:000537910.6EGF, AHR, SLC6A4, SLC19A1

Publications for Choriocarcinoma

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50PubMed
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Articles related to Choriocarcinoma:

(show top 50)    (show all 937)
idTitleAuthorsYear
1
Brain metastatic dissemination of choriocarcinoma complicated of aneurysmal rupture. (22033419)
2013
2
Ruptured cerebral aneurysm from choriocarcinoma. (23835464)
2013
3
Case of maternal and infantile choriocarcinoma following normal pregnancy. (24371634)
2012
4
The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells. (22677473)
2012
5
Coexistence of gastric adenocarcinoma and choriocarcinoma: complete response to trastuzumab and chemotherapy. (23525369)
2012
6
Pure choriocarcinoma of the ovary: a case report. (21860741)
2011
7
Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. (21993263)
2011
8
Choriocarcinoma after a nonterm pregnancy. (20626177)
2010
9
Changes in the expression of pituitary adenylate cyclase-activating polypeptide in the human placenta during pregnancy and its effects on the survival of JAR choriocarcinoma cells. (20449689)
2010
10
Primary pulmonary choriocarcinoma presenting with a hemothorax. (19395912)
2009
11
Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis. (18407327)
2009
12
Severe gastrointestinal bleeding secondary to duodenal metastasis from a choriocarcinoma. (19899941)
2009
13
STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. (19079545)
2008
14
Choriocarcinoma with pulmonary and cerebral metastases. (18946601)
2008
15
Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole. (18317216)
2008
16
Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation. (18362896)
2008
17
Immature teratoma with choriocarcinoma-like lesion of testis: case report of an unusual presentation. (17883088)
2007
18
The use of Alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells. (17307808)
2007
19
Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. (18059230)
2007
20
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. (16984618)
2006
21
Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. (16487037)
2006
22
Improvement in uterine choriocarcinoma complicated by life-threatening pulmonary infarction. (16553189)
2006
23
Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro. (16210391)
2006
24
Refractory metastatic choriocarcinoma treated surgically with polychemotherapy--case report. (17139992)
2006
25
Treatment and prognosis of post term choriocarcinoma in The Netherlands. (16790263)
2006
26
Embolization for hemorrhage of liver metastases from choriocarcinoma. (15979698)
2005
27
Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells. (16177192)
2005
28
Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. (15837074)
2005
29
Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3. (15316280)
2004
30
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. (12657510)
2003
31
Induction of apoptosis in human choriocarcinoma cell lines by treatment with 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone). (12375038)
2002
32
Massive feto-maternal hemorrhage: an early presentation of women with gestational choriocarcinoma. (12047317)
2002
33
Non-gestational choriocarcinoma in small intestine. (12546180)
2002
34
Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (10233754)
1999
35
Tamoxifen-mediated anti-cellular effect against a choriocarcinoma cell line. (9538145)
1998
36
Autocrine mechanism of epidermal growth factor in choriocarcinoma cell proliferation. (9027325)
1996
37
Treatment of resistant gestational choriocarcinoma with taxol: a report of two cases. (8626100)
1996
38
Functional characterization of L-alanine transport in a placental choriocarcinoma cell line (BeWo). (7886021)
1994
39
Characterization of 17 beta-hydroxysteroid dehydrogenase type 1 in choriocarcinoma cells: regulation by basic fibroblast growth factor. (7821700)
1994
40
In situ choriocarcinoma arising in partial hydatidiform mole: implications for the risk of persistent trophoblastic disease. (1409158)
1992
41
Insulin stimulates synthesis and release of human chorionic gonadotropin by choriocarcinoma cell lines. (1999176)
1991
42
Retinoic acid stimulates placental hormone secretion by choriocarcinoma cell lines in vitro. (1702702)
1991
43
cDNA-derived amino acid sequences of choriocarcinoma alpha- and beta-subunits of human choriogonadotropin. (2289629)
1990
44
Metastatic gestational choriocarcinoma: two cases. (3364839)
1988
45
Immobilized Datura stramonium agglutinin column chromatography, a novel method to discriminate the urinary hCGs of patients with invasive mole and choriocarcinoma from those of normal pregnant women and patients with hydatidiform mole. (3130349)
1988
46
Resistant gestational choriocarcinoma: successful treatment with vinblastine, bleomycin, and cisplatin (VBP). (6189602)
1983
47
Irradiation of liver metastases due to gestational choriocarcinoma. (6823396)
1983
48
Fatal gestational choriocarcinoma. Clinicopathologic study of patients treated at a trophoblastic disease center. (7116308)
1982
49
Gestational choriocarcinoma. Its origin in the placenta during seemingly normal pregnancy. (7235120)
1981
50
Gestational choriocarcinoma in Denmark 1940-1969. A reappraisal based on modern histologic criteria. (4340330)
1972

Genetic Variations for Choriocarcinoma

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Expression for genes affiliated with Choriocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

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Pathways for genes affiliated with Choriocarcinoma

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53Reactome, 49PharmGKB, 29KEGG
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Pathways related to Choriocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SLC22A2, ABCG2
210.7ALPPL2, ALPP

Compounds for genes affiliated with Choriocarcinoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.1AHR, CGB, CGB7, CYP19A1, LEP, ABCG2
2arginine4412.1CGB5, AHR, CYP19A1, LEP, ABCG2, SLC6A4
3cisplatin44 49 59 1114.9SLC19A1, SLC22A2, EGF, CGB5, CGB7, CGB
4cysteine4411.8ERVW-1, SLC6A4, LEP, AHR, EGF, SLC19A1
5alanine4411.8ALPP, CGB, PPARG, AHR, ABCG2, SLC6A4
6progesterone44 59 28 11 2415.7CGB5, EGF, CGB, CYP19A1, LEP, ABCG2
7steroid4411.7ERVW-1, LEP, EGF, CYP19A1, ERV3-1, AHR
8vegf4411.7PPARG, EGF, CGB5, CGB, LEP, AHR
9methotrexate44 49 1113.6CYP19A1, LEP, CGB7, CGB, CGB5, ABCG2
10genistein44 28 59 2 11 2416.6ALPP, ABCG2, PPARG, CYP19A1, AHR, CGB5
11progestin4411.5CYP19A1, ALPP, AHR, CGB5, EGF, SLC6A4
12thyroxine44 2412.5ALPP, LEP, CGB, CGB7, PPARG, AHR
13tamoxifen44 49 28 1114.4SLC6A4, CYP19A1, AHR, CGB5, ALPP
14estrone44 28 11 2414.4ABCG2, LEP, CYP19A1, CGB5, AHR
15nifedipine44 49 28 1114.4CGB5, LEP, ABCG2, SLC22A2, ALPP
16dihydrotestosterone44 28 11 2414.4EGF, CYP19A1, LEP, SLC6A4, CGB5
17estradiol44 11 2413.3CGB5, CGB, CYP19A1, CGB7
18serine4411.3ERVW-1, ENDOU, ALPP, LEP, SLC6A4
19epinephrine44 11 2413.3CGB5, LEP, ABCG2, SLC6A4, SLC22A2
20dexamethasone44 49 28 1114.3CGB5, AHR, ALPP, ABCG2
21leucovorin44 49 1113.3EGF, CGB5, CGB, SLC19A1
22metformin44 49 1113.3SLC22A2, CYP19A1, PPARG, LEP
23androstenedione44 2412.2LEP, CGB, CGB5, CYP19A1
24indomethacin44 59 28 1114.2LEP, CYP19A1, CGB5, PPARG, EGF
25phenobarbital44 28 1113.2PPARG, ALPP, ABCG2, AHR
26gnrh4411.2CGB7, CYP19A1, CGB
27zidovudine44 1112.2SLC22A2, CGB5, ERVW-1, ABCG2
28chrysin4411.2AHR, ABCG2, CYP19A1
29oestriol4411.2CGB, CGB7, CGB5
30corticosterone44 59 2413.2SLC22A2, SLC6A4, LEP, CGB5
31cetrorelix44 28 1113.1CGB5, LEP, EGF
32mifepristone44 59 28 1114.1EGF, CGB5, CGB, CYP19A1
33ctp4411.1CGB5, CGB7, CGB
34naringenin44 1112.1AHR, CYP19A1, ABCG2
35retinoic acid44 2412.1PPARG, CGB5, EGF, CGB7, AHR, CYP19A1
36clomiphene citrate4411.1CYP19A1, CGB5, CGB
37telmisartan44 28 1113.1PPARG, LEP, ABCG2
38vincristine44 49 1113.1SLC19A1, CGB5, CGB, ABCG2
39cycloheximide4411.1CGB5, ALPP
40glutamate4411.1ERVW-1, SLC6A4, AHR
41paclitaxel44 49 1113.0CYP19A1, CGB5, EGF, ABCG2
42estrogen4411.0SLC6A4
43verapamil44 49 28 11 2415.0SLC22A2, SLC6A4, ABCG2, ALPP
44norepinephrine44 11 2413.0SLC6A4, CGB5, LEP, SLC22A2, ALPP
45pge24411.0SLC22A2
46hydrocortisone44 2 59 1114.0CYP19A1, ALPP, EGF, ABCG2
47cocaine44 1111.9SLC6A4, SLC22A2, ALPP, LEP
48testolactone44 1111.9CYP19A1, CGB5
49butyrate4410.8ALPPL2
50lamivudine44 1111.5SLC22A2, LEP, ABCG2

GO Terms for genes affiliated with Choriocarcinoma

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16Gene Ontology
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Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.5ABCG2, SLC6A4, SLC22A2, SLC19A1, ERVW-1, ENPEP
2viral envelopeGO:01903110.4ERVW-1, ERV3-1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.7SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.7ALPPL2, ALPP

Products for genes affiliated with Choriocarcinoma

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Sources for Choriocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet