MCID: CHR074
MIFTS: 59

Choriocarcinoma malady

Rare diseases, Cancer diseases categories

Summaries for Choriocarcinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to gestational choriocarcinoma and teratoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs chlorambucil and vinblastine and the compounds chrysin and naringenin have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Choriocarcinoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

choriocarcinoma 9 44 11 46 63
choriocarcinoma, no icd-o subtype 9
chorioepithelioma nos 9
chorioepithelioma 9


External Ids:

Disease Ontology9 DOID:3594
NCIt41 C2948
MeSH36 D002822

Related Diseases for Choriocarcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma31.6EBF4
2teratoma30.7CGB5, ALPP, CGB7, CGB
3ectopic pregnancy30.6CGB, CGB7, CGB5
4adenocarcinoma30.6CGB, ERVW-1, AHR, EGF, CGB7, CGB5
5placental site trophoblastic tumor30.5CGB5, CGB
6breast cancer30.3ERVW-1, CYP19A1, AHR, EGF
7dysgerminoma30.3CGB5, ALPP
8hyperthyroidism30.2CGB, ALPP, LEP, CGB5
9germinoma30.2CGB5, CGB, ALPP
10testicular cancer30.2CGB5, ALPP, CGB
11leukemia30.1CGB, SLC19A1, ERVW-1, ALPP, AHR, ABCG2
12endodermal sinus tumor29.9ALPP, CGB5, CGB
13gestational trophoblastic neoplasm29.9CGB5, CGB, CGB7, ALPP
14down syndrome29.9SLC19A1, CGB5, CGB7, CGB
15seminoma29.9ERVW-1, CGB, CGB7, CGB5, ALPP
16cholera29.8ALPP, EGF, SLC6A4
17endometrial carcinoma29.8EGF, CYP19A1, AHR
18hypertension29.7LEP, SLC6A4, ENPEP, PPARG
19placental choriocarcinoma10.7
20invasive mole10.6
21germ cell tumors10.5
22choriocarcinoma of the testis10.5
23non-gestational choriocarcinoma10.4
24mixed germ cell tumor10.3
25cervicitis10.3
26choriocarcinoma of ovary10.3
27choroiditis10.3
28non-gestational ovarian choriocarcinoma10.3
29gestational ovarian choriocarcinoma10.3
30cerebritis10.3
31pineal region choriocarcinoma10.2
32hepatitis10.2
33mature teratoma10.2
34mediastinitis10.2
35aneurysm10.2
36partial hydatidiform mole10.2
37pediatric cns choriocarcinoma10.2
38fallopian tube gestational choriocarcinoma10.2
39childhood choriocarcinoma of the testis10.2
40duodenitis10.2
41epithelioid trophoblastic tumor10.2
42vaginitis10.2
43primary non-gestational choriocarcinoma of ovary10.2
44extragonadal germ cell tumor10.1CGB5
45aromatase excess syndrome10.1CYP19A1
46adult central nervous system choriocarcinoma10.1
47testicular monophasic choriocarcinoma10.1
48pulmonary artery choriocarcinoma10.1
49childhood choriocarcinoma of the ovary10.1
50hepatitis b10.1

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Symptoms for Choriocarcinoma

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Drugs & Therapeutics for Choriocarcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Choriocarcinoma

Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Search CenterWatch for Choriocarcinoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Choriocarcinoma

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Anatomical Context for Choriocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Choriocarcinoma:

34
Placenta, Ovary, Testis, Lung, Brain, Liver, Breast, Skin, Uterus, Cervix, Colon, Thyroid, Pituitary, Spinal cord, Testes, Pineal, Pancreas, Endothelial, Small intestine, Spleen, Bone, Lymph node, Tonsil, Eye, Skeletal muscle

Animal Models for Choriocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Choriocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.1PPARG, ABCG2, CYP19A1, AHR, LEP, SLC19A1
2MP:00053798.9PPARG, CYP19A1, AHR, LEP, EGF, SLC6A4
3MP:00053698.7HOPX, PPARG, CYP19A1, AHR, LEP, SLC6A4
4MP:00107718.7SLC19A1, PPARG, ABCG2, CYP19A1, AHR, LEP
5MP:00028738.6CYP19A1, ALPP, EGF, SLC6A4, SLC22A2, PPARG
6MP:00053898.4PPARG, CYP19A1, AHR, LEP, ALPP, EGF
7MP:00053768.2HOPX, PPARG, ABCG2, CYP19A1, AHR, LEP
8MP:00053787.8PPARG, CYP19A1, AHR, LEP, ALPP, EGF

Publications for Choriocarcinoma

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53PubMed
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Articles related to Choriocarcinoma:

(show top 50)    (show all 929)
idTitleAuthorsYear
1
Glycan profiling of gestational choriocarcinoma using a lectin microarray. (24424471)
2014
2
Brain metastases of choriocarcinoma--a report on two cases. (24313181)
2013
3
Induction of apoptosis and inhibition of invasion in choriocarcinoma JEG-3 cells by I+-calendic acid and I^-calendic acid. (24035100)
2013
4
NLRP7 and the genetics of post-molar choriocarcinomas in Senegal. (21948117)
2012
5
Case of maternal and infantile choriocarcinoma following normal pregnancy. (24371634)
2012
6
Mixed germ cell testicular tumor presenting as metastatic cutaneous choriocarcinoma. (21763587)
2011
7
Primary nongestational choriocarcinoma of the uterine cervix. (21245425)
2011
8
Gastric cancer with choriocarcinoma and yolk sac tumor components: case report. (21355958)
2011
9
Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. (20878477)
2011
10
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. (24371601)
2011
11
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
12
Induction of oxidative stress and cytotoxicity by PCB126 in JEG-3 human choriocarcinoma cells. (20446149)
2010
13
Cutaneous and systemic metastasis of a testicular choriocarcinoma. (20571348)
2010
14
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
15
Primary pulmonary choriocarcinoma presenting with a hemothorax. (19395912)
2009
16
Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. (18459557)
2008
17
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
18
Pure choriocarcinoma of testis with rare gingival and skin metastases. (17342276)
2007
19
Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells. (17520289)
2007
20
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
21
Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. (17165440)
2006
22
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
23
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. (16343490)
2006
24
IFNgamma pretreatment sensitizes human choriocarcinoma cells to etoposide-induced apoptosis. (16467399)
2006
25
Interaction of Jar choriocarcinoma cells with endothelial cell monolayers. (16085041)
2005
26
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
27
Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. (15457851)
2004
28
Primary choriocarcinoma of the jejunum: report of a case. (14669091)
2003
29
Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma. (12192487)
2002
30
Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo. (12399424)
2002
31
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. (11181528)
2001
32
Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. (10378027)
1999
33
Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (10233754)
1999
34
Differentiation markers and invasiveness: discordant regulation in normal trophoblast and choriocarcinoma cells. (9770367)
1998
35
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
36
A uterine choriocarcinoma in a virgin Donryu rat. (9437811)
1997
37
Gestational choriocarcinoma. (9443570)
1997
38
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
39
Choriocarcinoma]. (8778012)
1995
40
Transcriptional and posttranscriptional mechanisms in epidermal growth factor regulation of human chorionic gonadotropin (hCG) subunits and hCG receptor gene expression in human choriocarcinoma cells. (8070393)
1994
41
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
42
Characterization of upstream activation elements essential for the expression of germ cell alkaline phosphatase in human choriocarcinoma cells. (8314767)
1993
43
Gestational choriocarcinoma in a tubal ectopic pregnancy. (1315103)
1992
44
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway. (1317386)
1992
45
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. (1316854)
1992
46
Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. (1989875)
1991
47
Establishment and characterization of three new human gestational choriocarcinoma cell lines. (3171272)
1988
48
The role of thoracotomy in the management of the pulmonary metastases of gestational choriocarcinoma. (1212836)
1975
49
Gestational choriocarcinoma of the tube and ovary. (4730067)
1973
50
Histocompatibility antigens on the HL-A locus in gestational choriocarcinoma. (5406845)
1969

Variations for Choriocarcinoma

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Expression for genes affiliated with Choriocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

Search GEO for disease gene expression data for Choriocarcinoma.

Pathways for genes affiliated with Choriocarcinoma

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51PathCards, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database
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Compounds for genes affiliated with Choriocarcinoma

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1chrysin4610.2ABCG2, CYP19A1, AHR
2naringenin46 1211.0ABCG2, AHR, CYP19A1
3clomiphene citrate469.9CGB, CGB5, CYP19A1
4telmisartan46 30 1211.9LEP, PPARG, ABCG2
5cetrorelix46 30 1211.9CGB5, LEP, EGF
6metformin46 52 1211.8CYP19A1, SLC22A2, PPARG, LEP
7oestriol469.8CGB, CGB7, CGB5
8leucovorin46 52 1211.8CGB, SLC19A1, EGF, CGB5
9ctp469.7CGB5, CGB, CGB7
10androstenedione46 2510.7CGB5, CGB, CYP19A1, LEP
11mifepristone46 30 62 1212.7CYP19A1, CGB, EGF, CGB5
12corticosterone46 62 2511.6SLC6A4, CGB5, SLC22A2, LEP
13vincristine46 52 1211.6SLC19A1, ABCG2, CGB, CGB5
14testolactone46 1210.5CYP19A1, CGB5
15estrone46 30 25 1212.5AHR, CYP19A1, ABCG2, CGB5, LEP
16zidovudine46 52 1211.4CGB5, ABCG2, ERVW-1, SLC22A2
17dihydrotestosterone46 30 25 1212.4CYP19A1, CGB5, SLC6A4, EGF, LEP
18phenobarbital46 30 52 1212.4ALPP, PPARG, AHR, ABCG2
19epinephrine46 25 1211.4ABCG2, LEP, SLC6A4, SLC22A2, CGB5
20paclitaxel46 52 1211.4SLC19A1, EGF, CYP19A1, CGB5, ABCG2
21indomethacin46 30 62 1212.3PPARG, CGB5, EGF, LEP, CYP19A1
22hydrocortisone46 3 62 1212.2ABCG2, CYP19A1, ALPP, EGF
23atorvastatin46 52 30 25 1213.2ABCG2, PPARG, AHR, ALPP
24verapamil46 30 52 25 1213.1SLC6A4, SLC22A2, ALPP, ABCG2
25nifedipine46 30 52 1212.1ALPP, LEP, ABCG2, SLC22A2, CGB5
26cocaine46 1210.1LEP, SLC6A4, ALPP, SLC22A2
27doxorubicin46 52 1211.0SLC19A1, EGF, CGB5, CYP19A1, ABCG2
28progestin468.9EGF, ALPP, AHR, CYP19A1, CGB5, SLC6A4
29methotrexate52 46 1210.9CGB5, CGB7, ABCG2, CYP19A1, CGB, SLC19A1
30norepinephrine46 25 1210.9CGB5, LEP, ALPP, SLC6A4, SLC22A2
31gnrh468.8CGB5, CGB, SLC6A4, EGF, LEP, CYP19A1
32thyroxine46 259.8ALPP, AHR, PPARG, CGB7, LEP, CGB
33pge2468.6AHR, CYP19A1, PPARG, ALPP, EGF, SLC22A2
34progesterone46 30 62 25 1212.6ABCG2, LEP, EGF, SLC22A2, CGB, CYP19A1
35genistein46 30 62 3 25 1213.6ALPP, AHR, CYP19A1, PPARG, ABCG2, EGF
36cycloheximide468.6CYP19A1, PPARG, AHR, LEP, EGF, CGB5
37estradiol46 25 1210.4CGB5, CGB7, SLC22A2, EGF, LEP, AHR
38tamoxifen46 52 30 1211.4CGB5, SLC6A4, EGF, ABCG2, ALPP, LEP
39steroid468.4ERVW-1, ERV3-1, LEP, AHR, CYP19A1, CGB5
40dexamethasone46 52 30 1211.3PPARG, CGB5, EGF, CYP19A1, ALPP, ABCG2
41retinoic acid46 259.3EGF, PPARG, CYP19A1, CGB7, ALPP, AHR
42cisplatin46 52 62 1211.0CGB7, ABCG2, LEP, EGF, SLC19A1, SLC22A2
43estrogen467.9CGB5, SLC6A4, EGF, ALPP, LEP, CGB
44glutamate467.9AHR, ERVW-1, SLC19A1, SLC6A4, LEP, ALPP
45serine467.8EGF, AHR, LEP, ALPP, ERVW-1, SLC6A4
46vegf467.8PPARG, AHR, LEP, CGB5, ALPP, ENPEP
47cysteine467.7CGB, SLC22A2, SLC19A1, SLC6A4, EGF, ERVW-1
48alanine467.5ENPEP, PPARG, ABCG2, ALPP, AHR, ERVW-1
49testosterone46 62 25 1210.1PPARG, CGB5, CGB7, CGB, SLC6A4, EGF
50arginine466.9ERVW-1, ALPP, ENPEP, SLC22A2, CGB5, SLC6A4

GO Terms for genes affiliated with Choriocarcinoma

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17Gene Ontology
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Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral envelopeGO:0190319.3ERVW-1, ERV3-1
2plasma membraneGO:0058867.3ALPP, ERVW-1, ENPEP, EGF, SLC6A4, SLC19A1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.0SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7CGB, GH2, LEP

Products for genes affiliated with Choriocarcinoma

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Sources for Choriocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet