MCID: CHR074
MIFTS: 52

Choriocarcinoma malady

Summaries for Choriocarcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to adenocarcinoma and teratoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Abacavir transport and metabolism and Folate biosynthesis. The drugs chlorambucil and vinblastine and the compounds testosterone and arginine have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Choriocarcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

choriocarcinoma 8 43 10 45 61
choriocarcinoma, no icd-o subtype 8
chorioepithelioma nos 8
chorioepithelioma 8


External Ids:

Disease Ontology8 DOID:3594
NCIt40 C2948
MeSH35 D002822

Related Diseases for Choriocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7ERVW-1, CGB, CGB7, CGB5, AHR, ABCG2
2teratoma30.5CGB, CGB7, ALPP, CGB5, ALPPL2
3ectopic pregnancy30.5CGB5, CGB7, CGB
4placental site trophoblastic tumor30.4CGB5, CGB
5dysgerminoma30.1ALPP, CGB5
6hepatitis c30.1ERVW-1
7squamous cell carcinoma30.0CGB7, AHR, ENPEP, EGF, CGB, HOPX
8testicular cancer30.0ALPP, ALPPL2, CGB5, CGB
9germinoma30.0ALPP, CGB, CGB5
10gonadoblastoma30.0ALPPL2, ALPP
11gestational trophoblastic neoplasm29.8CGB, ALPP, CGB7, CGB5
12adenoma29.8CGB, CGB7, PPARG, AHR
13precocious puberty29.8LEP, CYP19A1, CGB5
14klinefelter's syndrome29.8CYP19A1, CGB
15placental choriocarcinoma10.8
16invasive mole10.6
17mixed germ cell tumor10.4
18fallopian tube gestational choriocarcinoma10.3
19testicular germ cell tumor10.3
20gestational ovarian choriocarcinoma10.3
21pineal region choriocarcinoma10.3
22partial hydatidiform mole10.2
23pediatric cns choriocarcinoma10.2
24epithelioid trophoblastic tumor10.2
25non-gestational ovarian choriocarcinoma10.2
26childhood choriocarcinoma of the testis10.2
27testicular monophasic choriocarcinoma10.1
28adult central nervous system choriocarcinoma10.1
29non-gestational choriocarcinoma10.1
30pulmonary artery choriocarcinoma10.1
31childhood choriocarcinoma of the ovary10.1
32herpes gestationis10.1
33thyrotoxicosis10.1
34uterine corpus choriocarcinoma10.1
35hepatitis c virus10.1
36germ cell tumors10.1
37hemorrhage, intracerebral10.1
38hepatitis e10.0
39gestational uterine corpus choriocarcinoma10.0
40tubular adenocarcinoma10.0
41hepatitis a10.0
42nonseminomatous germ cell tumor10.0
43ovarian germ cell tumor10.0
44hypoxia10.0
45venous thrombosis10.0
46choriocarcinoma of the central nervous system10.0
47prostate cancer10.0ALPPL2, CYP19A1, AHR, ABCG2, PPARG, ENPEP
48colorectal cancer10.0CGB, PPARG, ALPP, SLC19A1, ALPPL2, ABCG2
49leukemia10.0EGF, CGB, AHR, ERVW-1, ALPP, ABCG2
50pre-eclampsia10.0CGB, CGB7, SLC6A4, CGB5, LEP, ENPEP

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Clinical Features for Choriocarcinoma

Drugs & Therapeutics for Choriocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Choriocarcinoma

Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Search CenterWatch for Choriocarcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Choriocarcinoma

Anatomical Context for Choriocarcinoma

Animal Models for Choriocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Choriocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.1SLC19A1, ABCG2, LEP, CYP19A1, AHR, PPARG
2MP:001077110.8AHR, ABCG2, SLC6A4, SLC19A1
3MP:000537910.6SLC19A1, EGF, AHR, SLC6A4

Publications for Choriocarcinoma

Sources:
51PubMed
See all sources

Articles related to Choriocarcinoma:

(show top 50)    (show all 948)
idTitleAuthorsYear
1
Testicular seminomatous mixed germ cell tumor with choriocarcinoma and teratoma with secondary somatic malignancy: a case report. (24380446)
2014
2
Intracranial choriocarcinoma occurrence in males: Two cases and a review of the literature. (24179518)
2013
3
Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling. (24403258)
2013
4
NLRP7 and the genetics of post-molar choriocarcinomas in Senegal. (21948117)
2012
5
Effect on the production of soluble endoglin from human choriocarcinoma cells by preeclampsia sera. (22040284)
2012
6
Gastric cancer with choriocarcinoma and yolk sac tumor components: case report. (21355958)
2011
7
Mediastinal choriocarcinoma masquerading as relapsed hodgkin lymphoma. (22114578)
2011
8
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. (22053686)
2011
9
Unusual tumor: primary gastric choriocarcinoma. (21948579)
2011
10
Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. (21455559)
2011
11
Pulmonary metastases revealing choriocarcinoma. (20415215)
2010
12
Thymidylate synthase mRNA expression does not predict resistance to floxuridine in a choriocarcinoma cell line. (20626181)
2010
13
Epigenetic therapy in human choriocarcinoma. (24281181)
2010
14
A case of primary choriocarcinoma of the fallopian tube. (21126145)
2010
15
An aggressive course of de novo ulcerative colitis after renal transplantation: colonic adenocarcinoma with choriocarcinomatous differentiation. (19927772)
2009
16
Acute abdomen as initial presentation of gestational choriocarcinoma. (19288267)
2009
17
Live birth following treatment of post molar choriocarcinoma. (19769244)
2009
18
F-18 FDG PET/CT imaging in a case of primary choriocarcinoma in the retroperitoneum. (19542954)
2009
19
MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line. (19615077)
2009
20
Choriocarcinoma in an AIDS patient--relapsing but not fatal. (18574129)
2008
21
Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole. (18317216)
2008
22
A rare metastasis in the hand: a case of cutaneous metastasis of choriocarcinoma to the small finger. (17336850)
2007
23
Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. (17140564)
2007
24
Effect of Iodide on Human Choriogonadotropin, Sodium-Iodide Symporter Expression, and Iodide Uptake in BeWo Choriocarcinoma Cells. (17726079)
2007
25
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
26
Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells. (16790488)
2006
27
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (16391323)
2006
28
Ovarian choriocarcinoma in a rhesus monkey associated with elevated serum chorionic gonadotropin levels. (15753479)
2005
29
The expression of Cdk inhibitors p27kip1 and p57kip2 in mouse placenta and human choriocarcinoma JEG-3 cells. (15664414)
2005
30
Role of human leukocyte antigen-G small interference RNA in a choriocarcinoma cell line]. (16202295)
2005
31
Inhibition of HLA-G production in JEG-3 choriocarcinoma cells by RNA interference. (15209386)
2004
32
Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells. (14991266)
2004
33
Membranous glomerulonephritis in a patient with choriocarcinoma: case report. (12630648)
2003
34
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. (12538089)
2003
35
Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo. (12399424)
2002
36
The 15-deoxy-delta(12,14)-prostaglandin J(2)receptor, peroxisome proliferator activated receptor-gamma (PPARgamma) is expressed in human gestational tissues and is functionally active in JEG3 choriocarcinoma cells. (10833383)
2000
37
Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3. (9465263)
1998
38
Regulation of classical HLA class I genes in human choriocarcinoma cells by nuclear proteins binding to MHC class I regulatory elements. (8595132)
1995
39
Tumor necrosis factor-alpha affects in vitro hormone production by JEG-3 choriocarcinoma cell cultures. (8531193)
1995
40
Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. (8175977)
1994
41
Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (8061055)
1994
42
Gestational choriocarcinoma in norway, 1953-92 - an epidemiologic report. (21573475)
1993
43
Fibroblast growth factor enhances the transcription and stability of human chorionic gonadotropin beta-subunit messenger ribonucleic acid in Jar choriocarcinoma cells. (7678798)
1993
44
D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (8406465)
1993
45
Variant choriocarcinoma (BeWo) cells that differ in adhesion and migration on fibronectin display conserved patterns of integrin expression. (1478945)
1992
46
Tissue-specific expression and thyroid hormone regulation of the endogenous placental growth hormone variant and chorionic somatomammotropin genes in a human choriocarcinoma cell line. (1708334)
1991
47
Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule. (2295808)
1990
48
Establishment and characterization of a subline predisposed to pulmonary metastasis from a human gestational choriocarcinoma cell line in nude mice. (2520787)
1989
49
Immobilized Datura stramonium agglutinin column chromatography, a novel method to discriminate the urinary hCGs of patients with invasive mole and choriocarcinoma from those of normal pregnant women and patients with hydatidiform mole. (3130349)
1988
50
Mixed germ cell tumor of the ovary with pure choriocarcinoma metastasis. (3016631)
1986

Genetic Variations for Choriocarcinoma

Expression for genes affiliated with Choriocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

Search GEO for disease gene expression data for Choriocarcinoma.

Pathways for genes affiliated with Choriocarcinoma

Sources:
54Reactome, 50PharmGKB, 30KEGG
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Pathways related to Choriocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SLC22A2, ABCG2
210.7ALPPL2, ALPP

Compounds for genes affiliated with Choriocarcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1testosterone45 60 11 2415.1AHR, CGB, CGB7, CYP19A1, LEP, ABCG2
2arginine4512.1CGB5, AHR, CYP19A1, LEP, ABCG2, SLC6A4
3cisplatin45 50 60 1114.9SLC19A1, SLC22A2, EGF, CGB5, CGB7, CGB
4cysteine4511.8ERVW-1, SLC6A4, LEP, AHR, EGF, SLC19A1
5alanine4511.8ALPP, CGB, PPARG, AHR, ABCG2, SLC6A4
6progesterone45 60 29 11 2415.7CGB5, EGF, CGB, CYP19A1, LEP, ABCG2
7steroid4511.7ERVW-1, LEP, EGF, CYP19A1, ERV3-1, AHR
8vegf4511.7PPARG, EGF, CGB5, CGB, LEP, AHR
9methotrexate45 50 1113.6CYP19A1, LEP, CGB7, CGB, CGB5, ABCG2
10genistein45 29 60 2 11 2416.6ALPP, ABCG2, PPARG, CYP19A1, AHR, CGB5
11progestin4511.5CYP19A1, ALPP, AHR, CGB5, EGF, SLC6A4
12thyroxine45 2412.5ALPP, LEP, CGB, CGB7, PPARG, AHR
13tamoxifen45 50 29 1114.4SLC6A4, CYP19A1, AHR, CGB5, ALPP
14estrone45 29 11 2414.4ABCG2, LEP, CYP19A1, CGB5, AHR
15nifedipine45 50 29 1114.4CGB5, LEP, ABCG2, SLC22A2, ALPP
16dihydrotestosterone45 29 11 2414.4EGF, CYP19A1, LEP, SLC6A4, CGB5
17estradiol45 11 2413.3CGB5, CGB, CYP19A1, CGB7
18serine4511.3ERVW-1, ENDOU, ALPP, LEP, SLC6A4
19epinephrine45 11 2413.3CGB5, LEP, ABCG2, SLC6A4, SLC22A2
20dexamethasone45 50 29 1114.3CGB5, AHR, ALPP, ABCG2
21leucovorin45 50 1113.3EGF, CGB5, CGB, SLC19A1
22metformin45 50 1113.3SLC22A2, CYP19A1, PPARG, LEP
23androstenedione45 2412.2LEP, CGB, CGB5, CYP19A1
24indomethacin45 60 29 1114.2LEP, CYP19A1, CGB5, PPARG, EGF
25phenobarbital45 29 1113.2PPARG, ALPP, ABCG2, AHR
26gnrh4511.2CGB7, CYP19A1, CGB
27zidovudine45 1112.2SLC22A2, CGB5, ERVW-1, ABCG2
28chrysin4511.2AHR, ABCG2, CYP19A1
29oestriol4511.2CGB, CGB7, CGB5
30corticosterone45 60 2413.2SLC22A2, SLC6A4, LEP, CGB5
31cetrorelix45 29 1113.1CGB5, LEP, EGF
32mifepristone45 60 29 1114.1EGF, CGB5, CGB, CYP19A1
33ctp4511.1CGB5, CGB7, CGB
34naringenin45 1112.1AHR, CYP19A1, ABCG2
35retinoic acid45 2412.1PPARG, CGB5, EGF, CGB7, AHR, CYP19A1
36clomiphene citrate4511.1CYP19A1, CGB5, CGB
37telmisartan45 29 1113.1PPARG, LEP, ABCG2
38vincristine45 50 1113.1SLC19A1, CGB5, CGB, ABCG2
39cycloheximide4511.1CGB5, ALPP
40glutamate4511.1ERVW-1, SLC6A4, AHR
41paclitaxel45 50 1113.0CYP19A1, CGB5, EGF, ABCG2
42estrogen4511.0SLC6A4
43verapamil45 50 29 11 2415.0SLC22A2, SLC6A4, ABCG2, ALPP
44norepinephrine45 11 2413.0SLC6A4, CGB5, LEP, SLC22A2, ALPP
45pge24511.0SLC22A2
46hydrocortisone45 2 60 1114.0CYP19A1, ALPP, EGF, ABCG2
47cocaine45 1111.9SLC6A4, SLC22A2, ALPP, LEP
48testolactone45 1111.9CYP19A1, CGB5
49butyrate4510.8ALPPL2
50lamivudine45 1111.5SLC22A2, LEP, ABCG2

GO Terms for genes affiliated with Choriocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.5EGF, ABCG2, SLC6A4, SLC22A2, SLC19A1, ERVW-1
2viral envelopeGO:01903110.4ERV3-1, ERVW-1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.7SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.7ALPPL2, ALPP

Products for genes affiliated with Choriocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Choriocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet