MCID: CHR074
MIFTS: 59

Choriocarcinoma malady

Summaries for Choriocarcinoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to gestational choriocarcinoma and adenocarcinoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Abacavir transport and metabolism and Folate biosynthesis. The drugs chlorambucil and vinblastine and the compounds testosterone and arginine have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Choriocarcinoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

choriocarcinoma 8 42 10 44 60
choriocarcinoma, no icd-o subtype 8
chorioepithelioma nos 8
chorioepithelioma 8


External Ids:

Disease Ontology8 DOID:3594
NCIt39 C2948
MeSH34 D002822

Related Diseases for Choriocarcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma31.4EBF4
2adenocarcinoma30.6EGF, CGB5, CGB7, CGB, AHR, ABCG2
3placental site trophoblastic tumor30.3CGB5, CGB
4breast cancer30.3EGF, AHR, CYP19A1, ERVW-1
5hepatitis30.3ALPP
6leukemia30.2EGF, CGB, AHR, ABCG2, SLC19A1, ERVW-1
7hyperthyroidism30.1CGB5, CGB, LEP, ALPP, ALPPL2
8hepatitis b30.1ALPPL2, ALPP, AHR, CGB
9squamous cell carcinoma30.0EGF, CGB7, CGB, AHR, HOPX, ABCG2
10testicular cancer30.0CGB5, CGB, ALPP, ALPPL2
11gonadoblastoma30.0ALPPL2, ALPP
12seminoma29.7CGB5, CGB7, CGB, ERVW-1, ALPP, ALPPL2
13endodermal sinus tumor29.7CGB5, CGB, ALPP, ALPPL2
14down syndrome29.7CGB5, CGB7, CGB, SLC19A1
15gestational trophoblastic neoplasm29.7CGB5, CGB7, CGB, ALPP
16hypertension29.7PPARG, LEP, SLC6A4, ENPEP
17endometriosis29.7CYP19A1, AHR
18leydig cell tumor29.7CYP19A1, CGB5
19melanoma29.7ABCG2, AHR, CGB
20endometrial carcinoma29.7CYP19A1, EGF
21pancreatitis29.7ALPPL2, ALPP
22leiomyoma29.7CYP19A1, EGF
23klinefelter's syndrome29.7CYP19A1, CGB
24placental choriocarcinoma10.8
25choriocarcinoma of ovary10.5
26choriocarcinoma of the testis10.5
27non-gestational choriocarcinoma10.5
28fallopian tube gestational choriocarcinoma10.3
29cervicitis10.3
30non-gestational ovarian choriocarcinoma10.3
31choroiditis10.3
32gestational ovarian choriocarcinoma10.3
33gastric adenocarcinoma10.3
34cerebritis10.2
35pineal region choriocarcinoma10.2
36mature teratoma10.2
37mediastinitis10.2
38pediatric cns choriocarcinoma10.1
39epithelioid trophoblastic tumor10.1
40childhood choriocarcinoma of the testis10.1
41duodenitis10.1
42vaginitis10.1
43testicular monophasic choriocarcinoma10.1
44adult central nervous system choriocarcinoma10.1
45pulmonary artery choriocarcinoma10.1
46childhood choriocarcinoma of the ovary10.1
47herpes gestationis10.1
48hepatitis a10.1
49pulmonary embolism10.1
50thyrotoxicosis10.1

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Clinical Features for Choriocarcinoma

About this section

Drugs & Therapeutics for Choriocarcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Choriocarcinoma

Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Search CenterWatch for Choriocarcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Choriocarcinoma

About this section

Anatomical Context for Choriocarcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Choriocarcinoma:

32
Placenta, Ovary, Testis, Lung, Brain, Breast, Liver, Skin, Uterus, Cervix, Colon, Spinal cord, Pituitary, Thyroid, Endothelial, Pancreas, Testes, Pineal, Small intestine, Spleen, Eye, Lymph node, Bone, Tonsil, Skeletal muscle

Animal Models for Choriocarcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.1SLC19A1, ABCG2, LEP, CYP19A1, AHR, PPARG
2MP:001077110.8AHR, ABCG2, SLC6A4, SLC19A1
3MP:000537910.6SLC19A1, EGF, AHR, SLC6A4

Publications for Choriocarcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Choriocarcinoma:

(show top 50)    (show all 937)
idTitleAuthorsYear
1
Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. (24145647)
2014
2
Infantile choriocarcinoma in a neonate with massive liver involvement cured with chemotherapy and liver transplant. (21792032)
2011
3
Solitary choriocarcinoma in the lung. (20357625)
2010
4
Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma. (20134273)
2010
5
Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. (19924425)
2010
6
Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line. (19239424)
2009
7
Positron emission tomography/computed tomography evaluation for choriocarcinoma. (18992881)
2009
8
Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells. (19571381)
2009
9
Lumbar metastasis of choriocarcinoma. (19564760)
2009
10
Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells. (18719855)
2009
11
A rare case of cutaneous metastasis of postpartum choriocarcinoma. (19530557)
2009
12
Successful treatment of FIGO stage IV gestational choriocarcinoma occurring 2 months after delivery. (17521800)
2008
13
Treatment of infantile choriocarcinoma of the liver. (16206190)
2007
14
Heparanase expression correlates with metastatic capability in human choriocarcinoma. (17688924)
2007
15
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
16
Transvaginal sonographic findings of isolated intramural uterine choriocarcinoma mimicking an interstitial pregnancy. (16731898)
2006
17
Choriocarcinoma - a rare association with squamous cell carcinoma of esophagus. (16567899)
2006
18
Regulatory role of hepatocyte nuclear factor-4alpha on gastric choriocarcinoma function. (15990092)
2006
19
Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. (16445700)
2006
20
Interaction of Jar choriocarcinoma cells with endothelial cell monolayers. (16085041)
2005
21
Choriocarcinoma and gestational trophoblastic disease. (16310678)
2005
22
Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3. (15922086)
2005
23
Proteomic analysis of hyperoxia-induced responses in the human choriocarcinoma cell line JEG-3. (14997506)
2004
24
Cerebral metastasis in choriocarcinoma a case report]. (12741100)
2003
25
Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: an autopsy case report. (11940220)
2002
26
Cutaneous metastasis of gestational choriocarcinoma. (12065138)
2002
27
Expression of functional Fas ligand in choriocarcinoma. (12516633)
2002
28
Resistance to multiple agent chemotherapy including cisplatin after chronic low-dose oral etoposide administration in gestational choriocarcinoma. (11586044)
2001
29
Activity of docetaxel in chemoresistant gestational choriocarcinoma. (11104635)
2000
30
A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. (10986872)
2000
31
Pure primary choriocarcinoma of the urinary bladder with long-term survival. (11068319)
2000
32
Biological action of keratinocyte growth factor in BeWo cells, a human choriocarcinoma cell line. (10698046)
2000
33
Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. (10194533)
1999
34
Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy. (9766571)
1998
35
Unexpected death due to gestational choriocarcinoma: a report of two cases. (9885937)
1998
36
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
37
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
38
Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. (9419968)
1997
39
Hypoxia downregulates continuous and interleukin-1-induced expression of human chorionic gonadotropin in choriocarcinoma cells. (9290157)
1997
40
Choriocarcinoma of the bladder. Report of a case of primary tumor or late metastasis of a molar pregnancy. (7650666)
1995
41
Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). (7756345)
1995
42
Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. (8408014)
1993
43
Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor. (1638483)
1992
44
Identification of a soluble GM-CSF binding protein in the supernatant of a human choriocarcinoma cell line. (1531919)
1992
45
Modulation of transferrin-receptor activity and recycling after induced differentiation of BeWo choriocarcinoma cells. (2400396)
1990
46
Lectin binding in tissues from hydatidiform mole, invasive mole and choriocarcinoma to concanavalin-A, wheat germ agglutinin and peanut agglutinin. (2560369)
1989
47
Gestational choriocarcinoma presenting as endobronchial carcinoma. (3194870)
1988
48
Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma. (3346101)
1988
49
Activity of high-dose cis-platinum (NCI 119875) in combination with vincristine and methotrexate in drug-resistant gestational choriocarcinoma. A report of 17 cases. (575049)
1979
50
Hydatidiform mole, invasive mole and choriocarcinoma in Sweden 1958-1965. (5519491)
1970

Genetic Variations for Choriocarcinoma

About this section

Expression for genes affiliated with Choriocarcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

Search GEO for disease gene expression data for Choriocarcinoma.

Pathways for genes affiliated with Choriocarcinoma

About this section
Sources:
53Reactome, 49PharmGKB, 29KEGG
See all sources

Pathways related to Choriocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SLC22A2, ABCG2
210.7ALPPL2, ALPP

Compounds for genes affiliated with Choriocarcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.1AHR, CGB, CGB7, CYP19A1, LEP, ABCG2
2arginine4412.1CGB5, AHR, CYP19A1, LEP, ABCG2, SLC6A4
3cisplatin44 49 59 1114.9SLC19A1, SLC22A2, EGF, CGB5, CGB7, CGB
4cysteine4411.8ERVW-1, SLC6A4, LEP, AHR, EGF, SLC19A1
5alanine4411.8ALPP, CGB, PPARG, AHR, ABCG2, SLC6A4
6progesterone44 59 28 11 2415.7CGB5, EGF, CGB, CYP19A1, LEP, ABCG2
7steroid4411.7ERVW-1, LEP, EGF, CYP19A1, ERV3-1, AHR
8vegf4411.7PPARG, EGF, CGB5, CGB, LEP, AHR
9methotrexate44 49 1113.6CYP19A1, LEP, CGB7, CGB, CGB5, ABCG2
10genistein44 28 59 2 11 2416.6ALPP, ABCG2, PPARG, CYP19A1, AHR, CGB5
11progestin4411.5CYP19A1, ALPP, AHR, CGB5, EGF, SLC6A4
12thyroxine44 2412.5ALPP, LEP, CGB, CGB7, PPARG, AHR
13tamoxifen44 49 28 1114.4SLC6A4, CYP19A1, AHR, CGB5, ALPP
14estrone44 28 11 2414.4ABCG2, LEP, CYP19A1, CGB5, AHR
15nifedipine44 49 28 1114.4CGB5, LEP, ABCG2, SLC22A2, ALPP
16dihydrotestosterone44 28 11 2414.4EGF, CYP19A1, LEP, SLC6A4, CGB5
17estradiol44 11 2413.3CGB5, CGB, CYP19A1, CGB7
18serine4411.3ERVW-1, ENDOU, ALPP, LEP, SLC6A4
19epinephrine44 11 2413.3CGB5, LEP, ABCG2, SLC6A4, SLC22A2
20dexamethasone44 49 28 1114.3CGB5, AHR, ALPP, ABCG2
21leucovorin44 49 1113.3EGF, CGB5, CGB, SLC19A1
22metformin44 49 1113.3SLC22A2, CYP19A1, PPARG, LEP
23androstenedione44 2412.2LEP, CGB, CGB5, CYP19A1
24indomethacin44 59 28 1114.2LEP, CYP19A1, CGB5, PPARG, EGF
25phenobarbital44 28 1113.2PPARG, ALPP, ABCG2, AHR
26gnrh4411.2CGB7, CYP19A1, CGB
27zidovudine44 1112.2SLC22A2, CGB5, ERVW-1, ABCG2
28chrysin4411.2AHR, ABCG2, CYP19A1
29oestriol4411.2CGB, CGB7, CGB5
30corticosterone44 59 2413.2SLC22A2, SLC6A4, LEP, CGB5
31cetrorelix44 28 1113.1CGB5, LEP, EGF
32mifepristone44 59 28 1114.1EGF, CGB5, CGB, CYP19A1
33ctp4411.1CGB5, CGB7, CGB
34naringenin44 1112.1AHR, CYP19A1, ABCG2
35retinoic acid44 2412.1PPARG, CGB5, EGF, CGB7, AHR, CYP19A1
36clomiphene citrate4411.1CYP19A1, CGB5, CGB
37telmisartan44 28 1113.1PPARG, LEP, ABCG2
38vincristine44 49 1113.1SLC19A1, CGB5, CGB, ABCG2
39cycloheximide4411.1CGB5, ALPP
40glutamate4411.1ERVW-1, SLC6A4, AHR
41paclitaxel44 49 1113.0CYP19A1, CGB5, EGF, ABCG2
42estrogen4411.0SLC6A4
43verapamil44 49 28 11 2415.0SLC22A2, SLC6A4, ABCG2, ALPP
44norepinephrine44 11 2413.0SLC6A4, CGB5, LEP, SLC22A2, ALPP
45pge24411.0SLC22A2
46hydrocortisone44 2 59 1114.0CYP19A1, ALPP, EGF, ABCG2
47cocaine44 1111.9SLC6A4, SLC22A2, ALPP, LEP
48testolactone44 1111.9CYP19A1, CGB5
49butyrate4410.8ALPPL2
50lamivudine44 1111.5SLC22A2, LEP, ABCG2

GO Terms for genes affiliated with Choriocarcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.5EGF, ABCG2, SLC6A4, SLC22A2, SLC19A1, ERVW-1
2viral envelopeGO:01903110.4ERV3-1, ERVW-1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.7SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.7ALPPL2, ALPP

Products for genes affiliated with Choriocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Choriocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet