MCID: CHR074
MIFTS: 59

Choriocarcinoma malady

Rare diseases, Cancer diseases categories
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Summaries for Choriocarcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to gestational choriocarcinoma and teratoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs chlorambucil and vinblastine and the compounds chrysin and naringenin have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Choriocarcinoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

choriocarcinoma 8 43 10 45 62
choriocarcinoma, no icd-o subtype 8
chorioepithelioma nos 8
chorioepithelioma 8


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Disease Ontology8 DOID:3594
NCIt40 C2948
MeSH35 D002822

Related Diseases for Choriocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma31.6EBF4
2teratoma30.7CGB5, ALPP, CGB7, CGB
3ectopic pregnancy30.6CGB, CGB7, CGB5
4adenocarcinoma30.6CGB, ERVW-1, AHR, EGF, CGB7, CGB5
5placental site trophoblastic tumor30.5CGB5, CGB
6breast cancer30.3ERVW-1, CYP19A1, AHR, EGF
7dysgerminoma30.3CGB5, ALPP
8hyperthyroidism30.2CGB, ALPP, LEP, CGB5
9germinoma30.2CGB5, CGB, ALPP
10testicular cancer30.2CGB5, ALPP, CGB
11leukemia30.1CGB, SLC19A1, ERVW-1, ALPP, AHR, ABCG2
12endodermal sinus tumor29.9ALPP, CGB5, CGB
13gestational trophoblastic neoplasm29.9CGB5, CGB, CGB7, ALPP
14down syndrome29.9SLC19A1, CGB5, CGB7, CGB
15seminoma29.9ERVW-1, CGB, CGB7, CGB5, ALPP
16cholera29.8ALPP, EGF, SLC6A4
17endometrial carcinoma29.8EGF, CYP19A1, AHR
18hypertension29.7LEP, SLC6A4, ENPEP, PPARG
19placental choriocarcinoma10.7
20invasive mole10.6
21germ cell tumors10.5
22choriocarcinoma of the testis10.5
23non-gestational choriocarcinoma10.4
24mixed germ cell tumor10.3
25cervicitis10.3
26choriocarcinoma of ovary10.3
27choroiditis10.3
28non-gestational ovarian choriocarcinoma10.3
29gestational ovarian choriocarcinoma10.3
30cerebritis10.3
31pineal region choriocarcinoma10.2
32hepatitis10.2
33mature teratoma10.2
34mediastinitis10.2
35aneurysm10.2
36partial hydatidiform mole10.2
37pediatric cns choriocarcinoma10.2
38fallopian tube gestational choriocarcinoma10.2
39childhood choriocarcinoma of the testis10.2
40duodenitis10.2
41epithelioid trophoblastic tumor10.2
42vaginitis10.2
43primary non-gestational choriocarcinoma of ovary10.2
44extragonadal germ cell tumor10.1CGB5
45aromatase excess syndrome10.1CYP19A1
46adult central nervous system choriocarcinoma10.1
47testicular monophasic choriocarcinoma10.1
48pulmonary artery choriocarcinoma10.1
49childhood choriocarcinoma of the ovary10.1
50hepatitis b10.1

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Symptoms for Choriocarcinoma

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Drugs & Therapeutics for Choriocarcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Choriocarcinoma

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Anatomical Context for Choriocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Choriocarcinoma:

33
Placenta, Ovary, Testis, Lung, Brain, Liver, Breast, Skin, Uterus, Cervix, Colon, Thyroid, Pituitary, Spinal cord, Testes, Pineal, Pancreas, Endothelial, Small intestine, Spleen, Bone, Lymph node, Tonsil, Eye, Skeletal muscle

Animal Models for Choriocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Choriocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.1PPARG, ABCG2, CYP19A1, AHR, LEP, SLC19A1
2MP:00053798.9PPARG, CYP19A1, AHR, LEP, EGF, SLC6A4
3MP:00053698.7HOPX, PPARG, CYP19A1, AHR, LEP, SLC6A4
4MP:00107718.7SLC19A1, PPARG, ABCG2, CYP19A1, AHR, LEP
5MP:00028738.6CYP19A1, ALPP, EGF, SLC6A4, SLC22A2, PPARG
6MP:00053898.4PPARG, CYP19A1, AHR, LEP, ALPP, EGF
7MP:00053768.2HOPX, PPARG, ABCG2, CYP19A1, AHR, LEP
8MP:00053787.8PPARG, CYP19A1, AHR, LEP, ALPP, EGF

Publications for Choriocarcinoma

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52PubMed
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Articles related to Choriocarcinoma:

(show top 50)    (show all 929)
idTitleAuthorsYear
1
Glycan profiling of gestational choriocarcinoma using a lectin microarray. (24424471)
2014
2
Brain metastases of choriocarcinoma--a report on two cases. (24313181)
2013
3
Induction of apoptosis and inhibition of invasion in choriocarcinoma JEG-3 cells by I+-calendic acid and I^-calendic acid. (24035100)
2013
4
NLRP7 and the genetics of post-molar choriocarcinomas in Senegal. (21948117)
2012
5
Case of maternal and infantile choriocarcinoma following normal pregnancy. (24371634)
2012
6
Mixed germ cell testicular tumor presenting as metastatic cutaneous choriocarcinoma. (21763587)
2011
7
Primary nongestational choriocarcinoma of the uterine cervix. (21245425)
2011
8
Gastric cancer with choriocarcinoma and yolk sac tumor components: case report. (21355958)
2011
9
Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. (20878477)
2011
10
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. (24371601)
2011
11
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
12
Induction of oxidative stress and cytotoxicity by PCB126 in JEG-3 human choriocarcinoma cells. (20446149)
2010
13
Cutaneous and systemic metastasis of a testicular choriocarcinoma. (20571348)
2010
14
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
15
Primary pulmonary choriocarcinoma presenting with a hemothorax. (19395912)
2009
16
Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. (18459557)
2008
17
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
18
Pure choriocarcinoma of testis with rare gingival and skin metastases. (17342276)
2007
19
Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells. (17520289)
2007
20
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
21
Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. (17165440)
2006
22
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
23
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. (16343490)
2006
24
IFNgamma pretreatment sensitizes human choriocarcinoma cells to etoposide-induced apoptosis. (16467399)
2006
25
Interaction of Jar choriocarcinoma cells with endothelial cell monolayers. (16085041)
2005
26
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
27
Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. (15457851)
2004
28
Primary choriocarcinoma of the jejunum: report of a case. (14669091)
2003
29
Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma. (12192487)
2002
30
Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo. (12399424)
2002
31
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. (11181528)
2001
32
Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. (10378027)
1999
33
Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (10233754)
1999
34
Differentiation markers and invasiveness: discordant regulation in normal trophoblast and choriocarcinoma cells. (9770367)
1998
35
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
36
A uterine choriocarcinoma in a virgin Donryu rat. (9437811)
1997
37
Gestational choriocarcinoma. (9443570)
1997
38
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
39
Choriocarcinoma]. (8778012)
1995
40
Transcriptional and posttranscriptional mechanisms in epidermal growth factor regulation of human chorionic gonadotropin (hCG) subunits and hCG receptor gene expression in human choriocarcinoma cells. (8070393)
1994
41
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
42
Characterization of upstream activation elements essential for the expression of germ cell alkaline phosphatase in human choriocarcinoma cells. (8314767)
1993
43
Gestational choriocarcinoma in a tubal ectopic pregnancy. (1315103)
1992
44
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway. (1317386)
1992
45
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. (1316854)
1992
46
Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. (1989875)
1991
47
Establishment and characterization of three new human gestational choriocarcinoma cell lines. (3171272)
1988
48
The role of thoracotomy in the management of the pulmonary metastases of gestational choriocarcinoma. (1212836)
1975
49
Gestational choriocarcinoma of the tube and ovary. (4730067)
1973
50
Histocompatibility antigens on the HL-A locus in gestational choriocarcinoma. (5406845)
1969

Variations for Choriocarcinoma

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Expression for genes affiliated with Choriocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

Search GEO for disease gene expression data for Choriocarcinoma.

Pathways for genes affiliated with Choriocarcinoma

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50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database
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Compounds for genes affiliated with Choriocarcinoma

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1chrysin4510.2ABCG2, CYP19A1, AHR
2naringenin45 1111.0ABCG2, AHR, CYP19A1
3clomiphene citrate459.9CGB, CGB5, CYP19A1
4telmisartan45 29 1111.9LEP, PPARG, ABCG2
5cetrorelix45 29 1111.9CGB5, LEP, EGF
6metformin45 51 1111.8CYP19A1, SLC22A2, PPARG, LEP
7oestriol459.8CGB, CGB7, CGB5
8leucovorin45 51 1111.8CGB, SLC19A1, EGF, CGB5
9ctp459.7CGB5, CGB, CGB7
10androstenedione45 2410.7CGB5, CGB, CYP19A1, LEP
11mifepristone45 29 61 1112.7CYP19A1, CGB, EGF, CGB5
12corticosterone45 61 2411.6SLC6A4, CGB5, SLC22A2, LEP
13vincristine45 51 1111.6SLC19A1, ABCG2, CGB, CGB5
14testolactone45 1110.5CYP19A1, CGB5
15estrone45 29 24 1112.5AHR, CYP19A1, ABCG2, CGB5, LEP
16zidovudine45 51 1111.4CGB5, ABCG2, ERVW-1, SLC22A2
17dihydrotestosterone45 29 24 1112.4CYP19A1, CGB5, SLC6A4, EGF, LEP
18phenobarbital45 29 51 1112.4ALPP, PPARG, AHR, ABCG2
19epinephrine45 24 1111.4ABCG2, LEP, SLC6A4, SLC22A2, CGB5
20paclitaxel45 51 1111.4SLC19A1, EGF, CYP19A1, CGB5, ABCG2
21indomethacin45 29 61 1112.3PPARG, CGB5, EGF, LEP, CYP19A1
22hydrocortisone45 3 61 1112.2ABCG2, CYP19A1, ALPP, EGF
23atorvastatin45 51 29 24 1113.2ABCG2, PPARG, AHR, ALPP
24verapamil45 29 51 24 1113.1SLC6A4, SLC22A2, ALPP, ABCG2
25nifedipine45 29 51 1112.1ALPP, LEP, ABCG2, SLC22A2, CGB5
26cocaine45 1110.1LEP, SLC6A4, ALPP, SLC22A2
27doxorubicin45 51 1111.0SLC19A1, EGF, CGB5, CYP19A1, ABCG2
28progestin458.9EGF, ALPP, AHR, CYP19A1, CGB5, SLC6A4
29methotrexate51 45 1110.9CGB5, CGB7, ABCG2, CYP19A1, CGB, SLC19A1
30norepinephrine45 24 1110.9CGB5, LEP, ALPP, SLC6A4, SLC22A2
31gnrh458.8CGB5, CGB, SLC6A4, EGF, LEP, CYP19A1
32thyroxine45 249.8ALPP, AHR, PPARG, CGB7, LEP, CGB
33pge2458.6AHR, CYP19A1, PPARG, ALPP, EGF, SLC22A2
34progesterone45 29 61 24 1112.6ABCG2, LEP, EGF, SLC22A2, CGB, CYP19A1
35genistein45 29 61 3 24 1113.6ALPP, AHR, CYP19A1, PPARG, ABCG2, EGF
36cycloheximide458.6CYP19A1, PPARG, AHR, LEP, EGF, CGB5
37estradiol45 24 1110.4CGB5, CGB7, SLC22A2, EGF, LEP, AHR
38tamoxifen45 51 29 1111.4CGB5, SLC6A4, EGF, ABCG2, ALPP, LEP
39steroid458.4ERVW-1, ERV3-1, LEP, AHR, CYP19A1, CGB5
40dexamethasone45 51 29 1111.3PPARG, CGB5, EGF, CYP19A1, ALPP, ABCG2
41retinoic acid45 249.3EGF, PPARG, CYP19A1, CGB7, ALPP, AHR
42cisplatin45 51 61 1111.0CGB7, ABCG2, LEP, EGF, SLC19A1, SLC22A2
43estrogen457.9CGB5, SLC6A4, EGF, ALPP, LEP, CGB
44glutamate457.9AHR, ERVW-1, SLC19A1, SLC6A4, LEP, ALPP
45serine457.8EGF, AHR, LEP, ALPP, ERVW-1, SLC6A4
46vegf457.8PPARG, AHR, LEP, CGB5, ALPP, ENPEP
47cysteine457.7CGB, SLC22A2, SLC19A1, SLC6A4, EGF, ERVW-1
48alanine457.5ENPEP, PPARG, ABCG2, ALPP, AHR, ERVW-1
49testosterone45 61 24 1110.1PPARG, CGB5, CGB7, CGB, SLC6A4, EGF
50arginine456.9ERVW-1, ALPP, ENPEP, SLC22A2, CGB5, SLC6A4

GO Terms for genes affiliated with Choriocarcinoma

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16Gene Ontology
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Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral envelopeGO:0190319.3ERVW-1, ERV3-1
2plasma membraneGO:0058867.3ALPP, ERVW-1, ENPEP, EGF, SLC6A4, SLC19A1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.0SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7CGB, GH2, LEP

Products for genes affiliated with Choriocarcinoma

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Sources for Choriocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet