MCID: CHR074
MIFTS: 61

Choriocarcinoma malady

Rare diseases, Cancer diseases categories
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Summaries for Choriocarcinoma

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Wikipedia:65 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards based summary: Choriocarcinoma, also known as chorioepithelioma, is related to gestational choriocarcinoma and ectopic pregnancy. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs chlorambucil and vinblastine and the compounds chrysin and naringenin have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Choriocarcinoma

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Choriocarcinoma, Aliases & Descriptions:

Name: Choriocarcinoma 8 42 10 44 62
Chorioepithelioma 8 62
 
Choriocarcinoma, No Icd-O Subtype 8
Chorioepithelioma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3594
NCIt39 C2948
MeSH34 D002822

Related Diseases for Choriocarcinoma

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Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma32.3EBF4
2ectopic pregnancy31.1CGB, CGB7, CGB5
3placental site trophoblastic tumor31.1CGB5, CGB
4teratoma31.0CGB5, ALPP, CGB7, CGB
5dysgerminoma30.8CGB5, ALPP
6germinoma30.6CGB5, CGB, ALPP
7testicular cancer30.6CGB5, ALPP, CGB
8breast cancer30.4ERVW-1, CYP19A1, AHR, EGF
9endodermal sinus tumor30.4ALPP, CGB5, CGB
10hyperthyroidism30.3CGB, ALPP, LEP, CGB5
11adenocarcinoma30.3CGB, ERVW-1, AHR, EGF, CGB7, CGB5
12gestational trophoblastic neoplasm30.2CGB5, CGB, CGB7, ALPP
13down syndrome30.2SLC19A1, CGB5, CGB7, CGB
14seminoma30.1ERVW-1, CGB, CGB7, CGB5, ALPP
15precocious puberty30.1LEP, CYP19A1, CGB5
16cholera29.9ALPP, EGF, SLC6A4
17endometrial carcinoma29.9EGF, CYP19A1, AHR
18leukemia29.8CGB, SLC19A1, ERVW-1, ALPP, AHR, ABCG2
19hypertension29.3LEP, SLC6A4, ENPEP, PPARG
20pre-eclampsia29.3LEP, ERVW-1, ENPEP, CGB5, CGB, SLC6A4
21placental choriocarcinoma10.7
22invasive mole10.6
23extragonadal germ cell tumor10.6CGB5
24aromatase excess syndrome10.5CYP19A1
25germ cell tumors10.5
26choriocarcinoma of the testis10.5
27serotonin syndrome10.5CGB
28premature ejaculation10.4SLC6A4
29gestational trophoblastic tumor10.4CGB5, CGB
30ovarian disease10.4CYP19A1
31non-gestational choriocarcinoma10.4
32ovarian cyst10.4CYP19A1, CGB5
33ovarian hyperstimulation syndrome10.4CGB5, CYP19A1
34cryptococcosis10.4CGB5, CGB, CGB7
35sertoli cell tumor10.4CYP19A1, ALPP
36cervicitis10.4
37mixed germ cell tumor10.4
38transitional cell carcinoma10.3CGB7, CGB, CGB5
39choroiditis10.3
40choriocarcinoma of ovary10.3
41hyperprolactinemia10.3CGB5, CGB
42gynecomastia10.3CGB5, CYP19A1
43cryptorchidism10.3CYP19A1, CGB5, ALPP
44oligospermia10.3CGB5, AHR
45non-gestational ovarian choriocarcinoma10.3
46gestational ovarian choriocarcinoma10.3
47cerebritis10.3
48neural tube defects10.3CGB7, CGB, SLC19A1, CGB5
49embryonal cancer10.3CGB7, CGB5, CGB, ALPP
50breast cyst10.2CYP19A1, EGF, CGB5

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Symptoms for Choriocarcinoma

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Drugs & Therapeutics for Choriocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Choriocarcinoma

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Anatomical Context for Choriocarcinoma

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MalaCards organs/tissues related to Choriocarcinoma:

32
Placenta, Ovary, Testis, Lung, Brain, Liver, Breast, Skin, Uterus, Cervix, Colon, Spinal cord, Thyroid, Endothelial, Pituitary, Pancreas, Testes, Pineal, Eye, Bone, Lymph node, Spleen, Skeletal muscle, Small intestine, Tonsil

Animal Models for Choriocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.1ABCG2, CYP19A1, AHR, LEP, SLC19A1, PPARG
2MP:00053798.9SLC19A1, PPARG, CYP19A1, AHR, LEP, EGF
3MP:00053698.7HOPX, PPARG, SLC6A4, LEP, AHR, CYP19A1
4MP:00107718.7AHR, CYP19A1, PPARG, LEP, EGF, SLC6A4
5MP:00028738.6SLC22A2, SLC6A4, EGF, ALPP, CYP19A1, PPARG
6MP:00053898.4SLC19A1, PPARG, CYP19A1, AHR, LEP, ALPP
7MP:00053768.2HOPX, CYP19A1, AHR, LEP, SLC6A4, SLC19A1
8MP:00053787.8SLC19A1, SLC6A4, EGF, ALPP, LEP, AHR

Publications for Choriocarcinoma

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Articles related to Choriocarcinoma:

(show top 50)    (show all 951)
idTitleAuthorsYear
1
Choroidal metastases of choriocarcinoma. (25372318)
2014
2
Choriocarcinoma of the testis. (24949806)
2014
3
Glycan profiling of gestational choriocarcinoma using a lectin microarray. (24424471)
2014
4
Brain metastases of choriocarcinoma--a report on two cases. (24313181)
2013
5
Induction of apoptosis and inhibition of invasion in choriocarcinoma JEG-3 cells by I+-calendic acid and I^-calendic acid. (24035100)
2013
6
NLRP7 and the genetics of post-molar choriocarcinomas in Senegal. (21948117)
2012
7
Case of maternal and infantile choriocarcinoma following normal pregnancy. (24371634)
2012
8
Mixed germ cell testicular tumor presenting as metastatic cutaneous choriocarcinoma. (21763587)
2011
9
Primary nongestational choriocarcinoma of the uterine cervix. (21245425)
2011
10
Gastric cancer with choriocarcinoma and yolk sac tumor components: case report. (21355958)
2011
11
Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. (20878477)
2011
12
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. (24371601)
2011
13
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (20736774)
2010
14
Induction of oxidative stress and cytotoxicity by PCB126 in JEG-3 human choriocarcinoma cells. (20446149)
2010
15
Cutaneous and systemic metastasis of a testicular choriocarcinoma. (20571348)
2010
16
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
17
Primary pulmonary choriocarcinoma presenting with a hemothorax. (19395912)
2009
18
Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. (18459557)
2008
19
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
20
Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells. (17520289)
2007
21
A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. (16935862)
2006
22
Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. (17165440)
2006
23
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. (16632463)
2006
24
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. (16343490)
2006
25
IFNgamma pretreatment sensitizes human choriocarcinoma cells to etoposide-induced apoptosis. (16467399)
2006
26
Interaction of Jar choriocarcinoma cells with endothelial cell monolayers. (16085041)
2005
27
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
28
Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. (15457851)
2004
29
Primary choriocarcinoma of the jejunum: report of a case. (14669091)
2003
30
Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma. (12192487)
2002
31
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. (11181528)
2001
32
Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. (10378027)
1999
33
Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (10233754)
1999
34
Differentiation markers and invasiveness: discordant regulation in normal trophoblast and choriocarcinoma cells. (9770367)
1998
35
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (9445130)
1998
36
A uterine choriocarcinoma in a virgin Donryu rat. (9437811)
1997
37
Gestational choriocarcinoma. (9443570)
1997
38
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells. (9290147)
1997
39
Choriocarcinoma]. (8778012)
1995
40
Transcriptional and posttranscriptional mechanisms in epidermal growth factor regulation of human chorionic gonadotropin (hCG) subunits and hCG receptor gene expression in human choriocarcinoma cells. (8070393)
1994
41
Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. (7691711)
1993
42
Characterization of upstream activation elements essential for the expression of germ cell alkaline phosphatase in human choriocarcinoma cells. (8314767)
1993
43
Gestational choriocarcinoma in a tubal ectopic pregnancy. (1315103)
1992
44
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway. (1317386)
1992
45
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. (1316854)
1992
46
Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. (1989875)
1991
47
Establishment and characterization of three new human gestational choriocarcinoma cell lines. (3171272)
1988
48
The role of thoracotomy in the management of the pulmonary metastases of gestational choriocarcinoma. (1212836)
1975
49
Gestational choriocarcinoma of the tube and ovary. (4730067)
1973
50
Histocompatibility antigens on the HL-A locus in gestational choriocarcinoma. (5406845)
1969

Variations for Choriocarcinoma

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Expression for genes affiliated with Choriocarcinoma

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Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

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Pathways for genes affiliated with Choriocarcinoma

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Compounds for genes affiliated with Choriocarcinoma

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Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1chrysin4410.2ABCG2, CYP19A1, AHR
2naringenin44 1111.0ABCG2, AHR, CYP19A1
3clomiphene citrate449.9CGB, CGB5, CYP19A1
4telmisartan44 28 1111.9LEP, PPARG, ABCG2
5cetrorelix44 28 1111.9CGB5, LEP, EGF
6metformin44 50 1111.8CYP19A1, SLC22A2, PPARG, LEP
7oestriol449.8CGB, CGB7, CGB5
8leucovorin44 50 1111.8CGB, SLC19A1, EGF, CGB5
9ctp449.7CGB5, CGB, CGB7
10androstenedione44 2410.7CGB5, CGB, CYP19A1, LEP
11mifepristone44 28 61 1112.7CYP19A1, CGB, EGF, CGB5
12corticosterone44 61 2411.6SLC6A4, CGB5, SLC22A2, LEP
13vincristine44 50 1111.6SLC19A1, ABCG2, CGB, CGB5
14testolactone44 1110.5CYP19A1, CGB5
15estrone44 28 24 1112.5AHR, CYP19A1, ABCG2, CGB5, LEP
16zidovudine44 50 1111.4CGB5, ABCG2, ERVW-1, SLC22A2
17dihydrotestosterone44 28 24 1112.4CYP19A1, CGB5, SLC6A4, EGF, LEP
18phenobarbital44 28 50 1112.4ALPP, PPARG, AHR, ABCG2
19epinephrine44 24 1111.4ABCG2, LEP, SLC6A4, SLC22A2, CGB5
20paclitaxel44 50 1111.4SLC19A1, EGF, CYP19A1, CGB5, ABCG2
21indomethacin44 28 61 1112.3PPARG, CGB5, EGF, LEP, CYP19A1
22hydrocortisone44 2 61 1112.2ABCG2, CYP19A1, ALPP, EGF
23atorvastatin44 50 28 24 1113.2ABCG2, PPARG, AHR, ALPP
24verapamil44 28 50 24 1113.1SLC6A4, SLC22A2, ALPP, ABCG2
25nifedipine44 28 50 1112.1ALPP, LEP, ABCG2, SLC22A2, CGB5
26cocaine44 1110.1LEP, SLC6A4, ALPP, SLC22A2
27doxorubicin44 50 1111.0SLC19A1, EGF, CGB5, CYP19A1, ABCG2
28progestin448.9EGF, ALPP, AHR, CYP19A1, CGB5, SLC6A4
29methotrexate50 44 1110.9CGB5, CGB7, ABCG2, CYP19A1, CGB, SLC19A1
30norepinephrine44 24 1110.9CGB5, LEP, ALPP, SLC6A4, SLC22A2
31gnrh448.8CGB5, CGB, SLC6A4, EGF, LEP, CYP19A1
32thyroxine44 249.8ALPP, AHR, PPARG, CGB7, LEP, CGB
33pge2448.6AHR, CYP19A1, PPARG, ALPP, EGF, SLC22A2
34progesterone44 28 61 24 1112.6ABCG2, LEP, EGF, SLC22A2, CGB, CYP19A1
35genistein44 28 61 2 24 1113.6ALPP, AHR, CYP19A1, PPARG, ABCG2, EGF
36cycloheximide448.6CYP19A1, PPARG, AHR, LEP, EGF, CGB5
37estradiol44 24 1110.4CGB5, CGB7, SLC22A2, EGF, LEP, AHR
38tamoxifen44 50 28 1111.4CGB5, SLC6A4, EGF, ABCG2, ALPP, LEP
39steroid448.4ERVW-1, ERV3-1, LEP, AHR, CYP19A1, CGB5
40dexamethasone44 50 28 1111.3PPARG, CGB5, EGF, CYP19A1, ALPP, ABCG2
41retinoic acid44 249.3EGF, PPARG, CYP19A1, CGB7, ALPP, AHR
42cisplatin44 50 61 1111.0CGB7, ABCG2, LEP, EGF, SLC19A1, SLC22A2
43estrogen447.9CGB5, SLC6A4, EGF, ALPP, LEP, CGB
44glutamate447.9AHR, ERVW-1, SLC19A1, SLC6A4, LEP, ALPP
45serine447.8EGF, AHR, LEP, ALPP, ERVW-1, SLC6A4
46vegf447.8PPARG, AHR, LEP, CGB5, ALPP, ENPEP
47cysteine447.7CGB, SLC22A2, SLC19A1, SLC6A4, EGF, ERVW-1
48alanine447.5ENPEP, PPARG, ABCG2, ALPP, AHR, ERVW-1
49testosterone44 61 24 1110.1PPARG, CGB5, CGB7, CGB, SLC6A4, EGF
50arginine446.9ERVW-1, ALPP, ENPEP, SLC22A2, CGB5, SLC6A4

GO Terms for genes affiliated with Choriocarcinoma

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Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral envelopeGO:0190319.3ERVW-1, ERV3-1
2plasma membraneGO:0058867.3ALPP, ERVW-1, ENPEP, EGF, SLC6A4, SLC19A1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.0SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7CGB, GH2, LEP

Products for genes affiliated with Choriocarcinoma

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Sources for Choriocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet