MCID: CHR074
MIFTS: 59

Choriocarcinoma malady

Summaries for Choriocarcinoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by... more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype, is related to gestational choriocarcinoma and adenocarcinoma. An important gene associated with Choriocarcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Abacavir transport and metabolism and Folate biosynthesis. The drugs chlorambucil and vinblastine and the compounds testosterone and arginine have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and testis, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Choriocarcinoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

choriocarcinoma 8 42 10 44 60
choriocarcinoma, no icd-o subtype 8
chorioepithelioma nos 8
chorioepithelioma 8


External Ids:

Disease Ontology8 DOID:3594
NCIt39 C2948
MeSH34 D002822

Related Diseases for Choriocarcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Choriocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1gestational choriocarcinoma31.4EBF4
2adenocarcinoma30.6EGF, CGB5, CGB7, CGB, AHR, ABCG2
3placental site trophoblastic tumor30.3CGB5, CGB
4breast cancer30.3EGF, AHR, CYP19A1, ERVW-1
5hepatitis30.3ALPP
6leukemia30.2EGF, CGB, AHR, ABCG2, SLC19A1, ERVW-1
7hyperthyroidism30.1CGB5, CGB, LEP, ALPP, ALPPL2
8hepatitis b30.1ALPPL2, ALPP, AHR, CGB
9squamous cell carcinoma30.0EGF, CGB7, CGB, AHR, HOPX, ABCG2
10testicular cancer30.0CGB5, CGB, ALPP, ALPPL2
11gonadoblastoma30.0ALPPL2, ALPP
12seminoma29.7CGB5, CGB7, CGB, ERVW-1, ALPP, ALPPL2
13endodermal sinus tumor29.7CGB5, CGB, ALPP, ALPPL2
14down syndrome29.7CGB5, CGB7, CGB, SLC19A1
15gestational trophoblastic neoplasm29.7CGB5, CGB7, CGB, ALPP
16hypertension29.7PPARG, LEP, SLC6A4, ENPEP
17endometriosis29.7CYP19A1, AHR
18leydig cell tumor29.7CYP19A1, CGB5
19melanoma29.7ABCG2, AHR, CGB
20endometrial carcinoma29.7CYP19A1, EGF
21pancreatitis29.7ALPPL2, ALPP
22leiomyoma29.7CYP19A1, EGF
23klinefelter's syndrome29.7CYP19A1, CGB
24placental choriocarcinoma10.8
25choriocarcinoma of ovary10.5
26choriocarcinoma of the testis10.5
27non-gestational choriocarcinoma10.5
28fallopian tube gestational choriocarcinoma10.3
29cervicitis10.3
30non-gestational ovarian choriocarcinoma10.3
31choroiditis10.3
32gestational ovarian choriocarcinoma10.3
33gastric adenocarcinoma10.3
34cerebritis10.2
35pineal region choriocarcinoma10.2
36mature teratoma10.2
37mediastinitis10.2
38pediatric cns choriocarcinoma10.1
39epithelioid trophoblastic tumor10.1
40childhood choriocarcinoma of the testis10.1
41duodenitis10.1
42vaginitis10.1
43testicular monophasic choriocarcinoma10.1
44adult central nervous system choriocarcinoma10.1
45pulmonary artery choriocarcinoma10.1
46childhood choriocarcinoma of the ovary10.1
47herpes gestationis10.1
48hepatitis a10.1
49pulmonary embolism10.1
50thyrotoxicosis10.1

Graphical network of the top 20 diseases related to Choriocarcinoma:



Diseases related to choriocarcinoma

Clinical Features for Choriocarcinoma

About this section

Drugs & Therapeutics for Choriocarcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Choriocarcinoma

Drug clinical trials:

Search ClinicalTrials for Choriocarcinoma

Search NIH Clinical Center for Choriocarcinoma

Search CenterWatch for Choriocarcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Choriocarcinoma

About this section

Anatomical Context for Choriocarcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Choriocarcinoma:

32
Placenta, Ovary, Testis, Lung, Brain, Breast, Liver, Skin, Uterus, Colon, Cervix, Endothelial, Pituitary, Thyroid, Spinal cord, Pineal, Testes, Pancreas, Skeletal muscle, Spleen, Small intestine, Lymph node, Tonsil, Bone, Eye

Animal Models for Choriocarcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Choriocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.1SLC19A1, ABCG2, LEP, CYP19A1, AHR, PPARG
2MP:001077110.8SLC19A1, SLC6A4, ABCG2, AHR
3MP:000537910.6EGF, AHR, SLC6A4, SLC19A1

Publications for Choriocarcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Choriocarcinoma:

(show top 50)    (show all 937)
idTitleAuthorsYear
1
Glycan profiling of gestational choriocarcinoma using a lectin microarray. (24424471)
2014
2
Crosstalk between p38 and Smad3 through TGF-I^1 in JEG-3 choriocarcinoma cells. (23877620)
2013
3
The human leukocyte antigen G promotes trophoblast fusion and I^-hCG production through the Erk1/2 pathway in human choriocarcinoma cell lines. (23583402)
2013
4
Primary choriocarcinoma metastasizing to skeletal muscles, presenting as an abdominal wall mass: A rare presentation. (24082764)
2013
5
Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP). (23587111)
2013
6
A translocator protein ligand PK11195 shows antigrowth activity in human choriocarcinoma cells. (22528948)
2012
7
Atypical case of choriocarcinoma with breast metastasis. (24293893)
2012
8
Pituitary choriocarcinoma in an adolescent male: tumor-derived CG and GH delay diagnosis. (21658594)
2011
9
Stimulation of serotonergic 5-HT2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells. (21703684)
2011
10
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. (22053686)
2011
11
Effect of oxygen concentrations on sodium iodide symporter expression and iodide uptake and hCG expression in human choriocarcinoma BeWo cells. (21406611)
2011
12
Does malaoxon play a role in the geno- and cytotoxic effects of malathion on human choriocarcinoma cells? (21902555)
2011
13
Effects of anti-I^2-glycoprotein I antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cell line. (21501325)
2011
14
Gestational choriocarcinoma transmission following multiorgan donation. (20977645)
2010
15
Good prognosis for primary ovarian pure nongestational choriocarcinoma using the EMA/CO regime. (20349799)
2010
16
A case of jejunal choriocarcinoma detected by capsule endoscopy and double-balloon endoscopy. (20157888)
2010
17
Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines. (19133314)
2009
18
Acute abdomen as initial presentation of gestational choriocarcinoma. (19288267)
2009
19
Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma. (19665071)
2009
20
Choriocarcinoma in an AIDS patient--relapsing but not fatal. (18574129)
2008
21
Using choriocarcinoma to cause remission of other tumors: a novel approach to kill tumors. (17045411)
2007
22
Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells. (16439450)
2006
23
Caspase activity is downregulated in choriocarcinoma: a cDNA array differential expression study. (16443735)
2006
24
Choriocarcinoma presenting as a renal tumour. (17315596)
2006
25
Ovarian choriocarcinoma in a rhesus monkey associated with elevated serum chorionic gonadotropin levels. (15753479)
2005
26
Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. (15919610)
2005
27
Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells. (14972450)
2004
28
The HLA-G*0105N null allele induces cell surface expression of HLA-E molecule and promotes CD94/NKG2A-mediated recognition in JAR choriocarcinoma cell line. (15578261)
2004
29
Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins. (12542695)
2003
30
Regulation by human chorionic gonadotropin of sodium/iodide symporter gene expression in the JAr human choriocarcinoma cell line. (12021185)
2002
31
A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells. (11113121)
2001
32
Expression of constitutively active c-MET receptor in human choriocarcinoma. (11014955)
2000
33
Leydig cell tumor, mature teratoma, and nongestational choriocarcinoma in a single ovary. (10808019)
2000
34
Case report: Clostridium septicum infection presenting as liver abscess in a case of choriocarcinoma with liver metastasis. (10634163)
1999
35
Retinoic acid stimulates the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. (10026096)
1999
36
Phantom hCG and phantom choriocarcinoma. (9826481)
1998
37
Estrogen receptor expression and growth-promoting function in human choriocarcinoma cells. (9303438)
1997
38
Expression and function of autocrine motility factor receptor in human choriocarcinoma. (8751543)
1996
39
cis-acting elements and trans-acting proteins in the transcription of chorionic gonadotropin/luteinizing hormone receptor gene in human choriocarcinoma cells and placenta. (8756564)
1996
40
An extra gonadal non-gestational choriocarcinoma in a woman treated for an endometrial carcinoma. (7543866)
1995
41
Primary pulmonary choriocarcinoma in a four month old boy complicated with precocious puberty. (7942004)
1994
42
Ethanol modulates the hormone secretory responses induced by epidermal growth factor in choriocarcinoma cells. (7695043)
1994
43
Characterization of upstream activation elements essential for the expression of germ cell alkaline phosphatase in human choriocarcinoma cells. (8314767)
1993
44
Documentation of complete resolution of gestational choriocarcinoma in the oophorectomized patient. (8276305)
1993
45
Interferon production by cultured human trophoblasts and choriocarcinoma cell lines induced by Sendai virus. (2177096)
1990
46
Case-control study of gestational choriocarcinoma. (3338071)
1988
47
Vaginal metastasis of choriocarcinoma and invasive mole. Clinical and pathological characteristics, diagnosis and treatment. (2996843)
1985
48
Neoplastic cerebral aneurysm from metastatic gestational choriocarcinoma. Case report. (4040960)
1985
49
Anti-tumour activity of the epipodophyllin derivative VP16-213 (etoposide: NSC-141540) in gestational choriocarcinoma. (6154579)
1980
50
Gestational choriocarcinoma of the tube and ovary. (4730067)
1973

Genetic Variations for Choriocarcinoma

About this section

Expression for genes affiliated with Choriocarcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Choriocarcinoma

Search GEO for disease gene expression data for Choriocarcinoma.

Pathways for genes affiliated with Choriocarcinoma

About this section
Sources:
53Reactome, 49PharmGKB, 29KEGG
See all sources

Pathways related to Choriocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SLC22A2, ABCG2
210.7ALPPL2, ALPP

Compounds for genes affiliated with Choriocarcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Choriocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.1AHR, CGB, CGB7, CYP19A1, LEP, ABCG2
2arginine4412.1CGB5, AHR, CYP19A1, LEP, ABCG2, SLC6A4
3cisplatin44 49 59 1114.9SLC19A1, SLC22A2, EGF, CGB5, CGB7, CGB
4cysteine4411.8ERVW-1, SLC6A4, LEP, AHR, EGF, SLC19A1
5alanine4411.8ALPP, CGB, PPARG, AHR, ABCG2, SLC6A4
6progesterone44 59 28 11 2415.7CGB5, EGF, CGB, CYP19A1, LEP, ABCG2
7steroid4411.7ERVW-1, LEP, EGF, CYP19A1, ERV3-1, AHR
8vegf4411.7PPARG, EGF, CGB5, CGB, LEP, AHR
9methotrexate44 49 1113.6CYP19A1, LEP, CGB7, CGB, CGB5, ABCG2
10genistein44 28 59 2 11 2416.6ALPP, ABCG2, PPARG, CYP19A1, AHR, CGB5
11progestin4411.5CYP19A1, ALPP, AHR, CGB5, EGF, SLC6A4
12thyroxine44 2412.5ALPP, LEP, CGB, CGB7, PPARG, AHR
13tamoxifen44 49 28 1114.4SLC6A4, CYP19A1, AHR, CGB5, ALPP
14estrone44 28 11 2414.4ABCG2, LEP, CYP19A1, CGB5, AHR
15nifedipine44 49 28 1114.4CGB5, LEP, ABCG2, SLC22A2, ALPP
16dihydrotestosterone44 28 11 2414.4EGF, CYP19A1, LEP, SLC6A4, CGB5
17estradiol44 11 2413.3CGB5, CGB, CYP19A1, CGB7
18serine4411.3ERVW-1, ENDOU, ALPP, LEP, SLC6A4
19epinephrine44 11 2413.3CGB5, LEP, ABCG2, SLC6A4, SLC22A2
20dexamethasone44 49 28 1114.3CGB5, AHR, ALPP, ABCG2
21leucovorin44 49 1113.3EGF, CGB5, CGB, SLC19A1
22metformin44 49 1113.3SLC22A2, CYP19A1, PPARG, LEP
23androstenedione44 2412.2LEP, CGB, CGB5, CYP19A1
24indomethacin44 59 28 1114.2LEP, CYP19A1, CGB5, PPARG, EGF
25phenobarbital44 28 1113.2PPARG, ALPP, ABCG2, AHR
26gnrh4411.2CGB7, CYP19A1, CGB
27zidovudine44 1112.2SLC22A2, CGB5, ERVW-1, ABCG2
28chrysin4411.2AHR, ABCG2, CYP19A1
29oestriol4411.2CGB, CGB7, CGB5
30corticosterone44 59 2413.2SLC22A2, SLC6A4, LEP, CGB5
31cetrorelix44 28 1113.1CGB5, LEP, EGF
32mifepristone44 59 28 1114.1EGF, CGB5, CGB, CYP19A1
33ctp4411.1CGB5, CGB7, CGB
34naringenin44 1112.1AHR, CYP19A1, ABCG2
35retinoic acid44 2412.1PPARG, CGB5, EGF, CGB7, AHR, CYP19A1
36clomiphene citrate4411.1CYP19A1, CGB5, CGB
37telmisartan44 28 1113.1PPARG, LEP, ABCG2
38vincristine44 49 1113.1SLC19A1, CGB5, CGB, ABCG2
39cycloheximide4411.1CGB5, ALPP
40glutamate4411.1ERVW-1, SLC6A4, AHR
41paclitaxel44 49 1113.0CYP19A1, CGB5, EGF, ABCG2
42estrogen4411.0SLC6A4
43verapamil44 49 28 11 2415.0SLC22A2, SLC6A4, ABCG2, ALPP
44norepinephrine44 11 2413.0SLC6A4, CGB5, LEP, SLC22A2, ALPP
45pge24411.0SLC22A2
46hydrocortisone44 2 59 1114.0CYP19A1, ALPP, EGF, ABCG2
47cocaine44 1111.9SLC6A4, SLC22A2, ALPP, LEP
48testolactone44 1111.9CYP19A1, CGB5
49butyrate4410.8ALPPL2
50lamivudine44 1111.5SLC22A2, LEP, ABCG2

GO Terms for genes affiliated with Choriocarcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.5ABCG2, SLC6A4, SLC22A2, SLC19A1, ERVW-1, ENPEP
2viral envelopeGO:01903110.4ERVW-1, ERV3-1

Biological processes related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.7SLC22A2, ABCG2

Molecular functions related to Choriocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.7ALPPL2, ALPP

Products for genes affiliated with Choriocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Choriocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet