Choriocarcinoma malady

Wikipedia: Choriocarcinoma is a malignant, trophoblasticcancer, usually of the placenta. It is characterized by...⁴⁴ more...

MalaCards: Choriocarcinoma, also known as choriocarcinoma, no icd-o subtype (morphologic abnormality), is related to placental choriocarcinoma and gestational choriocarcinoma. An important gene associated with Choriocarcinoma is HOPX (HOP homeobox), and among its related pathways are Epithelial Adherens Junctions and Breast Cancer Regulation by Stathmin1. The drugs vinblastine sulfate and vinblastine and the compounds progesterone and calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Aliases & Descriptions:

choriocarcinoma 6 30 8 32 43 choriocarcinoma, no icd-o subtype (morphologic abnormality) 6 choriocarcinoma (disorder) 6

chorioepithelioma nos 6 chorioepithelioma 6

Diseases related to choriocarcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 882)

id	Related Disease	Score	Top Affiliating Genes
1	placental choriocarcinoma	39.1	LEP, MTOR, CGB, ASCL3, INS, MAFF
2	gestational choriocarcinoma	35.0	CGB5, CGB7, ENPEP, ENDOU, ALPP, NFE2L3
3	carcinoma	31.6	PIK3CB, PIGF, PIK3CG, LRP1, KLF6, PDE1A
4	placental site trophoblastic tumor	30.5	LNPEP, CGA, CGB, CGB5, INHA
5	adenocarcinoma	30.1	PIK3CB, PIK3CG, LRP1, KLF6, PCNA, SERPINB5
6	down syndrome	29.8	MYC, RARA, PAPPA, CGA, CGB, CGB5
7	gestational trophoblastic neoplasm	29.7	PAM, CHM, CGA, CGB5, CDKN1C, INHA
8	endodermal sinus tumor	29.6	CGB, CGB5, CEACAM5, INHA, ALPP, ALPPL2
9	epithelioid trophoblastic tumor	29.6	LNPEP, CGA, CGB5, INHA, MCAM, ALPP
10	teratocarcinoma	29.6	MYC, RARA, LAMA1, CGA, JUN, FST
11	dysgerminoma	29.5	CGA, CGB, CGB5, INHA, FGFR2, ALPL
12	ectopic pregnancy	29.5	LIF, PAPPA, CGA, CGB, CGB5, CGB7
13	gastric adenocarcinoma	29.5	SERPINB5, MYC, CGB7, CFLAR, CEACAM5, JUN
14	teratoma	29.1	PCNA, LIF, CGA, CGB, CGB5, CGB7
15	leukemia	28.5	PIK3CB, PIK3CG, LRP1, KLF6, PDE1A, RETN
16	hepatitis	28.1	GZMB, MGAT3, FASLG, GPC3, F2, ALB
17	germ cell tumor	28.0	PIGF, PCNA, LIF, LGALS1, CGA, CGB
18	mediastinitis	27.3	PIK3CG, PCNA, MYC, CGA, CGB, JUN
19	thyroiditis	27.2	ZNF71, PIK3CB, PIGF, PIK3CG, LRP1, PDE1A
20	breast cancer	27.1	VDR, MMP2, FLT1, GSTP1, FGFR2, IL1B
21	melanoma	26.0	PIK3CB, PIK3CG, LRP1, KLF6, KISS1, KISS1R
22	hepatitis b	25.7	IL17A, IFNG, F2, ALB, CAT, NOS3
23	cholesterol	25.6	PIK3CB, PIK3CG, LRP1, PDE1A, RETN, VDR
24	adenomatous polyposis coli	25.3	PIK3CG, MYC, JUP, CDKN1A, APC, HNF4A
25	cervicitis	25.3	PIK3CG, PCNA, GCH1, SERPINB5, VDR, MYC
26	hypoxia	25.3	PIK3CB, PIGF, PIK3CG, LRP1, PCNA, GCM1
27	respiratory failure	25.2	CGB5, INS, FGF7, IL1B, ANXA5, IFNG
28	cholera	24.6	LGALS1, CGA, ATP6V0A2, CD9, MME, FOS
29	cervical carcinoma	23.5	PIK3CG, PCNA, VDR, MYC, LIF, CGB7
30	cerebritis	22.2	PIGF, PIK3CG, LRP1, KLF6, PCNA, MYC
31	polyposis	22.1	PIK3CG, KLF6, PCNA, VDR, MYC, LIFR
32	hyperglycemia	21.8	PIK3CB, PIK3CG, RETN, BDNF, LEP, LEPR
33	sinusitis	21.2	PCNA, MYC, CGA, CGB7, CDKN1A, MMP2
34	pediatric cns embryonal cell carcinoma	15.9	VDR, RARA, LIF, LIFR, CGA, CGB
35	cryptorchidism	15.1	LEP, CGA, CGB5, ALPP, ALPPL2, GNRH1
36	adrenal hyperplasia	15.0	LEP, CGA, CGB, CGB5, INS, FDX1
37	adrenal adenoma	15.0	CGA, CDKN1C, INS, IGF2, HSD11B2, CYP11A1
38	hypogonadotropism	14.9	KISS1, KISS1R, LEP, LEPR, CGA, CGB5
39	thyrotoxicosis	14.9	LEP, CGA, CGB7, INS, ALB, ALPP
40	germinoma	14.8	CGA, CGB, CGB5, CGB7, INHA, APC
41	lung carcinoma	14.8	PIK3CG, KLF6, PCNA, SERPINB5, MYC, RARA
42	kaposi's sarcoma	14.8	CGB5, CFLAR, CEBPB, CD9, FGF4, FGFR2
43	placental insufficiency	14.7	LNPEP, PAPPA, LGALS1, LEP, CGA, FLT1
44	kallmann syndrome	14.7	KISS1, KISS1R, LEP, LEPR, CGA, CGB5
45	leydig cell tumor	14.7	LGALS1, CGA, CGB, CGB5, INHA, INSR
46	pseudohermaphroditism	14.7	CGB5, ALPP, HSD17B13, HSD3B1, HSD3BP4, CYP19A1
47	androgen insensitivity syndrome	14.7	LNPEP, CGA, INHA, INS, IGF2, ALPPL2
48	cerebellar hypoplasia	14.7	JAG1, FGFR2, MAPK10, GH1, PTTG1, CYP11A1
49	gynecomastia	14.6	LEP, CGA, CGB, CGB5, INHA, GNRH1
50	sertoli-leydig cell tumor	14.6	INHA, ALPP, HSD3B1, HSD3BP4, CYP19A1, SRY

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chlorambucil, dactinomycin, vinblastine, vinblastine sulfate

MalaCards organs/tissues related to choriocarcinoma:

²²

MGI Mouse Phenotypes related to choriocarcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	12.1	VDR, RARA, RASA1, LEP, CDKN1C, IRS1
2	embryogenesis phenotype	MP:0005380	11.9	PIK3CB, KLF6, SERPINB5, MYC, RASA1, LIFR
3	growth/size phenotype	MP:0005378	11.9	PIK3CB, PIK3CG, LRP1, KLF6, KISS1, KISS1R
4	craniofacial phenotype	MP:0005382	11.2	RASA1, BDNF, LAMA5, FST, JAG1, CDKN1C
5	normal phenotype	MP:0002873	11.1	LRP1, KISS1R, GCM1, MYC, RARA, BDNF
6	nervous system phenotype	MP:0003631	11.1	LRP1, KISS1, KISS1R, GCM1, MYC, RARA
7	endocrine/exocrine gland phenotype	MP:0005379	11.0	KISS1, KISS1R, CDKN1B, CDKN1C, ASCL2, INHA
8	renal/urinary system phenotype	MP:0005367	10.9	KISS1, KISS1R, RARA, SCARB2, LEPR, MTOR
9	mortality/aging	MP:0010768	10.9	PIK3CB, LRP1, KLF6, KISS1, KISS1R, GCM1
10	hematopoietic system phenotype	MP:0005397	10.8	KLF6, KISS1R, PCNA, CFLAR, JAG1, JAK1
11	skeleton phenotype	MP:0005390	10.7	PIK3CG, LRP1, VDR, MYC, RARA, LIF
12	no phenotypic analysis	MP:0003012	10.7	PCNA, LNPEP, MYC, RASA1, PAK4, BDNF
13	immune system phenotype	MP:0005387	10.6	LRP1, KISS1R, VDR, RARA, LGALS1, LEPR
14	respiratory system phenotype	MP:0005388	10.5	LIF, PAM, BDNF, LEPR, ATP7A, ATOX1
15	liver/biliary system phenotype	MP:0005370	10.5	KLF6, RETN, LIF, XYLT2, ATP7A, ATP8B1
16	reproductive system phenotype	MP:0005389	10.4	KLF6, KISS1, KISS1R, VDR, RARA, LIF
17	behavior/neurological phenotype	MP:0005386	10.4	LRP1, KISS1R, LNPEP, LIF, BDNF, KCNIP3
18	integument phenotype	MP:0010771	10.3	PIK3CG, KLF6, KISS1, KISS1R, MYC, LIF
19	pigmentation phenotype	MP:0001186	10.1	MYC, CHM, ATP7A, ATOX1, CDKN1B, FGFR2
20	homeostasis/metabolism phenotype	MP:0005376	9.9	PIK3CB, PIK3CG, LRP1, RETN, KISS1, KISS1R
21	other phenotype	MP:0005395	9.8	RARA, LEPR, LAMA5, ATOX1, JAK2, MME
22	hearing/vestibular/ear phenotype	MP:0005377	9.7	VDR, MYC, RARA, RASA1, BDNF, SCARB2
23	digestive/alimentary phenotype	MP:0005381	9.2	KISS1, KISS1R, VDR, MYC, RARA, LIF
24	vision/eye phenotype	MP:0005391	8.2	RARA, LIF, BDNF, LEP, LEPR, CHM
25	muscle phenotype	MP:0005369	8.2	PIK3CG, LRP1, MYC, RARA, LIF, LGALS1
26	cardiovascular system phenotype	MP:0005385	8.0	PIK3CB, PIK3CG, LRP1, KLF6, VDR, LNPEP
27	cellular phenotype	MP:0005384	7.8	PIK3CB, PIK3CG, KLF6, PCNA, GCM1, SERPINB5
28	tumorigenesis	MP:0002006	7.6	PIK3CB, MYC, RARA, LEP, LEPR, CEBPB
29	adipose tissue phenotype	MP:0005375	7.6	LRP1, RETN, MYC, LIF, PAM, LEP

Articles related to choriocarcinoma:

(show top 50)    (show all 338)

id	Title	Authors	Year	Affiliating Genes
1	Effects of Wnt5a protein on proliferation and apoptos is in JAR choriocarcinoma cells. (21461571)	Peng S.... Wang H.	2011	WNT5A
2	Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell lines. (19968964)	Jiao Y.... Liu W.	2010	LRP1
3	Transcription regulation in differential expression o f the human GSTP1 gene in breast and choriocarcinoma cells. (20387634)	Slonchak A.M.... Yu Obolenska M.	2009	GSTP1
4	Allelic loss of the PTEN gene and mutation of the TP5 3 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma. (19665071)	Tate G.... Mitsuya T.	2009	TP53, PTEN, CDKN3
5	JWA sensitizes P-glycoprotein-mediated drug-resistant choriocarcinoma cells to etoposide via JNK and mitochondrial-associated signal pathway. (19492242)	Zhang Y.... Xu S.	2009	MAPK8
6	Primary sinonasal choriocarcinoma. (19302957)	Bell D.M.... Luna M.A.	2009	CGA, CGB7
7	Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells. (17901237)	Wu X.... Nakanishi T.	2008	CYP19A1, SLC23A2
8	STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. (19079545)	Rigourd V.... Vaiman D.	2008	ENG, STOX1, ERVW-1
9	Expression of caveolin-1 and the invasion of choriocarcinoma (18460778)	Liu H.N.... Yu R.	2008	CAV1
10	Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells. (17520289)	Adams Y.... Andrews K.T.	2007	IFNG
11	Regulatory role of hepatocyte nuclear factor-4alpha on gastric choriocarcinoma function. (15990092)	Tochigi N.... Ishikura H.	2006	HNF4A, HLA-G, CGB5
12	Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells. (16356544)	Hardman B.... Ackland M.L.	2006	ATOX1, SLC31A1
13	The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells. (17141338)	Niimi T.... Kitagawa Y.	2006	LAMA1, KLF6
14	Transfection of antisense chorionic gonadotropin beta gene into choriocarcinoma cells suppresses the cell proliferation and induces apoptosis. (15886246)	Hamada A.L.... Maruo T.	2005	CGB5, CGB7
15	Expression of the 5-HT2A serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin. (15950062)	Sonier B.... Vaillancourt C.	2005	HTR2A
16	Changes in gene expression profiles of hydatidiform mole and choriocarcinoma as compared with trophoblast hyperplasia (15733390)	Cui J.Q.... Li J.Q.	2004	RRM2, TK1
17	Endothelin-2 down-regulation occurs in parallel with the anti-proliferative effect of dimethylsulfoxide in BeWO human choriocarcinoma cell line. (15619356)	Rebourcet R.... Ferre F.	2004	EDN2
18	Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. (14628141)	Blohm M.E.... GAPbel U.	2004	CGB
19	Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures. (12771237)	Higuchi T.... Fujii S.	2003	MCAM
20	Expression of functional Fas ligand in choriocarcinoma. (12516633)	Hammer A.... Dohr G.	2002	FASLG
21	Effects of estrogen on leptin gene promoter activatio n in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors alpha and beta. (11369444)	O'Neil J.S.... Henson M.C.	2001	LEP
22	First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells. (11087729)	Kuhn J.... Kleesiek K.	2001	XYLT2, XYLT1
23	Gastric choriocarcinoma shows characteristics of aden ocarcinoma and gestational choriocarcinoma: a comparative genomic hybridization and fluorescence in situ hybridization study. (11552718)	Liu A.Y.... Chung S.C.	2001	CGB7
24	Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo. (10833370)	Fujisawa K.... Miyakawa I.	2000	TGFB1
25	Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain. (10463590)	Takamatsu S.... Kobata A.	1999	MAN2A1, MGAT3, MGAT4A
26	Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG. (10451222)	Birken S.... Canfield R.	1999	CGB5
27	Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. (10502498)	Letcher R.J.... van den Berg M.	1999	CYP19A1
28	Characterization of glucose transport and glucose transporters in the human choriocarcinoma cell line, BeWo. (10527819)	Shah S.W.... Hundal H.S.	1999	SLC2A5
29	BeWo choriocarcinoma cells produce laminin 10. (9601079)	Church H.J.... Aplin J.D.	1998	LAMA5
30	Human choriocarcinoma JAR cells constitutively expres s pro-interleukin-1beta that can be released with Fc(gamma) receptor engagement . (9545006)	Jarvis J.N.... Moore H.T.	1998	IL1B
31	Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3. (9465263)	Drenth H.J.... van den Berg M.	1998	CYP19A1
32	Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma. (9766657)	Fukushima K.... Yamashita K.	1998	FUT2, ST3GAL3
33	c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma. (9513871)	Fulop V.... Berkowitz R.S.	1998	CSF1R
34	Trophoblastic tumors of the testis other than classic choriocarcinoma: 'monophasic' choriocarcinoma and placental site trophoblastic tumor: a report of two cases. (9060597)	Ulbright T.M.... Scully R.E.	1997	CGB5
35	Attenuation of human chorionic gonadotropin release by nitric oxide in choriocarcinoma cell lines. (8869591)	Myat-Thanda .... Matsuura S.	1996	NOS1, CGB5
36	Choriocarcinoma (8778012)	Wierzchniewska A.... Romanowicz-Makowska H.	1995	CGB5
37	Consequences of antisense human chorionic gonadotrophin-alpha subunit cDNA expression in human choriocarcinoma JAR cells. (7545401)	Cao H.... Rao C.V.	1995	CGA
38	Regulation of classical HLA class I genes in human choriocarcinoma cells by nuclear proteins binding to MHC class I regulatory elements. (8595132)	Wakimoto A.... Tanizawa O.	1995	HLA-G
39	Involvement of a protein distinct from transcription enhancer factor-1 (TEF-1) in mediating human chorionic somatomammotropin gene enhancer function through the GT-IIC enhanson in choriocarcinoma and COS cells. (7775450)	Jiang S.W.... Eberhardt N.L.	1995	TEAD1
40	Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters. (8193164)	Wang J.... Chen S.	1994	CYP19A1
41	Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity. (7961121)	Ino K.... Tomoda Y.	1994	ANPEP, CPQ
42	Functional expression of the nitrobenzylthioinosine-sensitive nucleoside transporter of human choriocarcinoma (BeWo) cells in isolated oocytes of Xenopus laevis. (8192666)	Boumah C.E.... Cass C.E.	1994	SLC29A1
43	Characterization of 17 beta-hydroxysteroid dehydrogenase type 1 in choriocarcinoma cells: regulation by basic fibroblast growth factor. (7821700)	Lewintre E.J.... Vihko R.	1994	NUDT6
44	Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. (8061055)	Prasad P.D.... Ganapathy V.	1994	FOLR1, FOLR2
45	Induction of germ-cell alkaline phosphatase by butyrate and cyclic AMP in BeWo choriocarcinoma cells. (7504459)	Telfer J.F.... Green C.D.	1993	ALPPL2
46	Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma. (8504434)	Holmgren L.... Ohlsson R.	1993	PDGFB
47	Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells. (1309352)	Ritvos O.... Voutilainen R.	1992	CYP19A1, CYP11A1, ADCY10
48	Long-term treatment in infantile choriocarcinoma. (1580153)	Hongo T.... Igarashi Y.	1992	CGB5
49	Modulation of transferrin-receptor activity and recyc ling after induced differentiation of BeWo choriocarcinoma cells. (2400396)	van Der Ende A.... Strous G.J.	1990	TFRC
50	Cytovillin and other microvillar proteins of human choriocarcinoma cells. (2592436)	Pakkanen R.... Vaheri A.	1989	EZR

Genes related to choriocarcinoma according to GeneCards:

(show top 50)    (show all 337)

id	Symbol	Description	Score	GeneCards Section Context
1	HOPX	HOP homeobox	11.1	Publications, Summaries, Aliases & Descriptions, Expressions
2	ERV3-1	endogenous retrovirus group 3, member 1	11.0	Summaries, Publications
3	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
4	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
5	ENDOU	endonuclease, polyU-specific	11.0
6	EBF4	early B-cell factor 4	11.0
7	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
8	ENPEP	glutamyl aminopeptidase (aminopeptidase A)	11.0	Publications
9	ERVW-1	endogenous retrovirus group W, member 1	11.0	Publications
10	SLC22A2	solute carrier family 22 (organic cation transporter), member 2	11.0	Publications
11	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Functions, Publications
12	ALPP	alkaline phosphatase, placental	11.0	Publications
13	AHR	aryl hydrocarbon receptor	11.0	Publications
14	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
15	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
16	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
17	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
18	EGF	epidermal growth factor	11.0	Publications
19	LEP	leptin	11.0	Publications
20	ASCL3	achaete-scute complex homolog 3 (Drosophila)	11.0
21	CSH2	chorionic somatomammotropin hormone 2	11.0	Publications
22	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	11.0	Publications
23	SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	11.0	Publications
24	CSHL1	chorionic somatomammotropin hormone-like 1	11.0
25	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
26	ASCL2	achaete-scute complex homolog 2 (Drosophila)	11.0
27	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
28	DLX3	distal-less homeobox 3	11.0	Publications
29	CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	11.0	Publications
30	PGRMC1	progesterone receptor membrane component 1	11.0	Publications
31	GH2	growth hormone 2	11.0	Publications
32	RRM2	ribonucleotide reductase M2	11.0	Publications
33	DIO3	deiodinase, iodothyronine, type III	11.0
34	DLX4	distal-less homeobox 4	11.0	Publications
35	PLIN2	perilipin 2	11.0	Publications
36	TFPI2	tissue factor pathway inhibitor 2	11.0	Publications
37	MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	11.0	Publications
38	SLC6A19	solute carrier family 6 (neutral amino acid transporter), member 19	11.0	Publications
39	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	11.0	Publications
40	HLA-E	major histocompatibility complex, class I, E	11.0	Publications
41	PLIN1	perilipin 1	11.0	Publications
42	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Publications
43	GJA5	gap junction protein, alpha 5, 40kDa	11.0	Publications
44	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
45	DKK1	dickkopf 1 homolog (Xenopus laevis)	11.0	Publications
46	SLC5A6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	11.0	Publications
47	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
48	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
49	FOLR1	folate receptor 1 (adult)	11.0	Publications
50	FST	follistatin	11.0	Publications

Pathways related to choriocarcinoma according to GeneDecks:

(show top 50)    (show all 229)

id	Pathway	Score	Top Affiliating Genes
1	Epithelial Adherens Junctions36	11.8	CEBPB, JUP, FGF4, FGF7, IGF2, GNRH1
2	Breast Cancer Regulation by Stathmin136	11.4	LIFR, FGF4, FGF7, FGFR2, MAPK10, GH2
3	Paxillin Interactions36	11.3	LIFR, PAK4, BDNF, FLT1, INSR, FGF4
4	Jak-STAT signaling pathway20	11.3	PIK3CB, PIK3CG, MYC, LIFR, LEP, LEPR
5	Glioma Invasiveness36	11.2	BDNF, FGF4, FGF7, GNRH1, GH1, GH2
6	CREB Pathway36	11.1	BDNF, FGF4, FGF7, FGFR2, IGF2R, IGF2
7	ILK Signaling36	11.1	LIFR, BDNF, LAMA1, LAMA5, CEBPB, JUN
8	JNK Pathway36	11.1	LIFR, PAK4, CEBPB, JUN, IRS1, FLT1
9	Development Prolactin receptor signaling10	11.0	PIK3CB, MYC, CEBPB, JUN, JAK2, IRF1
10	Development_Prolactin receptor signaling41	11.0	PIK3CB, MYC, CEBPB, JUN, JAK2, IRF1
11	Actin-Based Motility by Rho Family GTPases36	10.8	PAK4, BDNF, FGF4, FGF7, IGF1, GH1
12	Nuclear Receptor Activation by Vitamin-A36	10.5	RARA, BDNF, FLT1, FGF4, FGF7, FGFR2
13	eNOS Signaling36	10.5	LIFR, BDNF, INSR, FGF4, FGF7, FGFR2
14	ERK Signaling36	10.4	MYC, LIFR, PAK4, LAMA1, LAMA5, FLT1
15	Rac1 Pathway36	10.4	PAK4, BDNF, JUN, FGF4, FGF7, FGFR2
16	PTEN Pathway36	10.3	BDNF, LAMA1, LAMA5, FLT1, FGF4, FGF7
17	GPCR Pathway36	10.3	LIFR, PAK4, BDNF, JUN, FOS, FLT1
18	PPAR Pathway36	10.3	FLT1, FGF4, FGF7, FGFR2, MAPK1, IGF2
19	Intracellular Calcium Signaling36	10.2	LIFR, BDNF, FLT1, INSR, FGF4, FGF7
20	Activation of PKC through GPCR36	10.2	PDE1A, BDNF, FLT1, FGF4, FGF7, FGFR2
21	GSK3 Signaling36	10.1	LIFR, BDNF, CDH11, FLT1, INSR, FGF4
22	DHA Signaling36	10.1	BDNF, FLT1, FGF4, FGF7, FGFR2, IL1B
23	ERK5 Signaling36	10.0	MYC, BDNF, FOS, FLT1, FGF4, IL6ST
24	mTOR Pathway36	10.0	BDNF, IRS1, INS, INSR, FGF4, FGF7
25	Estrogen Pathway36	10.0	LIFR, BDNF, JUN, FOS, FLT1, INSR
26	NFAT in Immune Response36	10.0	LIFR, BDNF, JUN, FOS, FLT1, INSR
27	p53 Mediated Apoptosis36	9.9	BDNF, FLT1, FGF4, FGF7, FGFR2, IGF2R
28	Activation of PKA through GPCR36	9.8	PDE1A, LIFR, BDNF, FLT1, INSR, FGF4
29	Nanog in Mammalian ESC Pluripotency36	9.8	LIFR, BDNF, FLT1, INSR, FGF4, FGF7
30	TGF-Beta Pathway36	9.7	BDNF, JUN, FOS, FLT1, FGF4, FGF7
31	Pancreatic Adenocarcinoma36	9.7	LIFR, BDNF, JAK1, JAK2, CDKN1A, CDKN1B
32	Rap1 Pathway36	9.7	LIFR, BDNF, INSR, FGF4, FGF7, FGFR2
33	Endothelin-1 Signaling Pathway36	9.7	MYC, LIFR, FLT1, INSR, FGFR2, IL1B
34	14-3-3 Induced Intracellular Signaling36	9.6	LIFR, BDNF, JUN, FLT1, INSR, FGF4
35	Rho Family GTPases36	9.6	LIF, LIFR, PAK4, BDNF, LAMA1, LAMA5
36	NF-KappaB (p50-p65) Pathway36	9.5	BDNF, FLT1, FGF4, FGF7, FGFR2, IL1B
37	NF-KappaB Family Pathway36	9.4	BDNF, FLT1, FGF4, FGF7, FGFR2, IL1B
38	p70S6K Signaling36	9.4	BDNF, JAK1, JAK2, IRS1, FLT1, INS
39	Apoptotic Pathways in Synovial Fibroblasts36	9.3	BDNF, CFLAR, FLT1, FGF4, FGF7, FGFR2
40	Cellular Apoptosis Pathway36	9.2	BDNF, CFLAR, FLT1, FGF4, FGF7, FGFR2
41	p38 Signaling36	9.2	LIF, LIFR, BDNF, FLT1, INSR, FGF4
42	Tec Kinases Signaling36	9.2	LIFR, PAK4, BDNF, JAK1, JAK2, FOS
43	Molecular Mechanisms of Cancer36	9.1	PIK3CG, MYC, RARA, RASA1, LIF, BDNF
44	Antioxidant Action of Vitamin-C36	9.1	LIF, LIFR, BDNF, JUN, JAK2, FOS
45	Cytokine-cytokine receptor interaction20	9.0	LIF, LIFR, LEP, LEPR, FLT1, IL17A
46	PAK Pathway36	9.0	LIF, PAK4, BDNF, FLT1, FGF4, FGF7
47	MAPK Signaling36	8.8	MYC, LIFR, PAK4, BDNF, LAMA1, LAMA5
48	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	VDR, CGA, JUN, CDKN1C, FOS, IL1B
49	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.4	VDR, CGA, JUN, CDKN1C, FOS, IL1B
50	Pathways in cancer20	8.4	PIK3CB, PIK3CG, MYC, RARA, MTOR, LAMA1

Compounds related to choriocarcinoma according to GeneDecks:

(show top 50)    (show all 503)

id	Compound	Score	Top Affiliating Genes
1	progesterone32 42 9 18 9	18.3	KISS1, PCNA, SERPINB5, LNPEP, RARA, LIF
2	calcium32 9 18 9	16.8	LRP1, PDE1A, RETN, KISS1, KISS1R, SET
3	testosterone32 9 18 9	15.7	KISS1, PCNA, SERPINB5, VDR, RARA, LIF
4	glucose32	12.6	KISS1, GCH1, LGALS1, LAP3, CGB, CFLAR
5	cysteine32	12.5	LRP1, PCNA, VDR, RARA, LIF, BLZF1
6	leucine32	12.4	LRP1, LNPEP, MYC, BLZF1, SCARB2, MTOR
7	cholesterol32 9 18 9	15.2	PIK3CB, LRP1, RETN, LIF, LIFR, BLZF1
8	atp32	12.1	PIK3CB, LIF, BLZF1, BDNF, MTOR, CGB5
9	ribonucleic acid32	12.1	KLF6, MYC, RARA, LIF, BLZF1, LEPR
10	forskolin32 42 9 9	14.9	RETN, GCM1, LNPEP, LIF, BLZF1, BDNF
11	gnrh32	11.7	KISS1R, LEP, LEPR, CGB, CGB5, CGB7
12	heparin32 9 18 9	14.6	PIK3CG, LRP1, LIF, PAPPA, LGALS1, LAMA1
13	cyclic amp32 18	12.5	KLF6, PDE1A, LIF, BDNF, CGA, CGB
14	3beta-hydroxysteroid32	11.4	CGA, CGB5, INHA, FDX1, IGF2, HSD11B2
15	progestins32	11.4	LIF, JAK2, MKI67, IGF2, GNRH1, HSD17B13
16	dmso32	11.3	CGA, CGB5, INSR, ALOX5, ALPP, GNRH1
17	gp 13032	11.3	LIF, LIFR, LEPR, CEBPB, JAK1, JAK2
18	verapamil32 34 9 18 9	15.2	LRP1, MYC, CGA, JAK2, INSR, GSTP1
19	phosphotyrosine32	11.0	PIK3CB, PIK3CG, LRP1, RASA2, RASA1, BLZF1
20	polysaccharide32	10.9	LIF, SCARB2, LGALS1, LAP3, CGB5, CEACAM1
21	egcg32	10.8	PIK3CG, MAPK8, MAPK10, CAT, ERBB3, ERVK-6
22	acetylcholine32 9 18 9	13.8	LIF, BLZF1, BDNF, LEP, CGA, CDKN3
23	cyclophosphamide32 34 9 9	13.8	APOH
24	thyroxine32 18	11.8	RETN, PCNA, VDR, LEP, LEPR, CGA
25	calcitriol32 42 9 18 9	14.7	PIK3CB, VDR, MYC, RARA, LIF, S100G
26	corticosterone32 18	11.6	LIF, BDNF, LEPR, CGB5, FOS, FDX1
27	prostaglandin32	10.6	LIF, CGA, CGB5, FST, MME, IL17A
28	tamoxifen32 34 9 9	13.5	PCNA, SERPINB5, VDR, MYC, RARA, BDNF
29	nitric oxide32 9 18 9	13.4	PIK3CB, PIGF, KLF6, RETN, GCH1, SERPINB5
30	vitamin d32	10.2	LRP1, VDR, RARA, LEPR, S100G, CGA
31	cyclosporin a32 42	11.2	PIK3CG, VDR, MYC, LIF, BLZF1, LEP
32	5-aza-2deoxycytidine32	10.2	PCNA, SERPINB5, MYC, CFLAR, JUP, FST
33	okadaic acid32 42	11.1	MYC, BLZF1, MTOR, JUN, CDKN3, FOS
34	glutamine32	10.1	PIK3CG, PCNA, VDR, BLZF1, LGALS1, LEPR
35	imatinib32 34 9 9	13.1	PIK3CG, MYC, RARA, MTOR, CFLAR, CEACAM1
36	gefitinib32 34 9 9	12.9	PIK3CG, MTOR, CEACAM5, CDKN1A, CDKN1B, CDKN3
37	bleomycin32 9 9	11.7	LAP3, CGB, CGB7, CDKN3, GSTP1, FGF7
38	bromodeoxyuridine32	9.7	PCNA, MYC, BDNF, LEPR, FST, CDKN1A
39	gf 109203x32 42	10.6	PIK3CB, PIK3CG, JUN, JAK2, CDKN1A, CDKN3
40	dexamethasone32 42 34 9 9	13.4	LRP1, RETN, PCNA, VDR, MYC, RARA
41	losartan32 34 9 9	12.4	PCNA, LEP, FOS, IRS1, ENPEP, IGF1
42	resveratrol32 9 18 9	12.1	PIK3CG, PCNA, VDR, MTOR, JUN, CDKN1A
43	sb 20358032 42	9.9	VDR, LIF, CDKN1A, CDKN1B, MMP2, FOS
44	gsno32	8.6	CEBPB, JUN, CDKN3, INSR, GSTP1, IFNG
45	paclitaxel32 34 9 9	11.5	PIK3CG, PCNA, LNPEP, MYC, RARA, LIF
46	methotrexate32 34 42 9 9	12.0	PCNA, LEP, CGA, CGB, CGB5, CGB7
47	15-deoxy-delta-12,14-prostaglandin j232	7.9	PIK3CG, MYC, JUN, JAK1, JAK2, CDKN1A
48	indomethacin32 9 9	9.8	PCNA, MYC, BDNF, LGALS1, LEP, CGA
49	curcumin32	7.3	PIK3CG, MYC, JUN, JAK1, JAK2, CDKN1A
50	pdtc32	6.6	PIK3CG, SERPINB5, CFLAR, JUN, CDKN1A, MMP2

Cellular components related to choriocarcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	11.4	PLIN2, GJA1, CAV1, CAT, CASP10, EZR
2	membrane	GO:016020	11.3	SLC1A5, SLC22A3, CSF1, NUCB1, STS, TFRC
3	basolateral plasma membrane	GO:016323	10.8	TGFA, SLC2A1, SLC29A1, SLC22A5, SLC23A2, SLC29A2
4	integral to plasma membrane	GO:005887	10.8	CSF2RA, CSF1R, OXTR, TFRC, THBD, EDNRB
5	apical plasma membrane	GO:016324	10.8	OXTR, SLC26A4, SLC29A1, SLC7A5, SLC22A5, SLC3A2
6	extracellular region	GO:005576	10.7	EPOR, TGFB1, TIMP4, TIMP2, TIMP1, EGF
7	cytoplasm	GO:005737	10.5	NOS3, RPS6KB1, PITRM1, PFN1, PDGFB, KRT7
8	nucleus	GO:005634	10.5	NOS3, NOS2, PLIN2, CREBBP, CREB1, NOTCH1
9	nucleoplasm	GO:005654	9.7	RXRA, NOTCH1, CREBBP, CREB1, SMAD3, NR5A1
10	cell surface	GO:009986	9.6	THBD, TIMP2, PDGFB, PDGFA, RPS6KB1, TGFA
11	external side of plasma membrane	GO:009897	9.6	ANXA5, ANPEP, IFNG, ICAM1, CALR, ENG
12	platelet alpha granule lumen	GO:031093	9.5	HGF, TGFB1, TIMP1, EGF, PDGFB, PDGFA
13	extracellular space	GO:005615	8.8	AFP, TIMP4, EGF, EDN2, PDGFA, RNPEP
14	cytosol	GO:005829	7.9	CYP19A1, ODC1, CUL7, CTNND1, NTRK2, PPARG

Biological processes related to choriocarcinoma according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:007267	11.8	GNRH1, GJA1, GJA5, PDGFA, PGF, ESR2
2	transmembrane transport	GO:055085	11.8	SLC2A1, ALB, ATP8B1, ATP6V0A2, SLC6A3, HMOX2
3	signal transduction	GO:007165	11.7	EGF, HIF1A, TGFBR1, STAT3, OXT, CSF1R
4	small molecule metabolic process	GO:044281	11.7	STAR, STS, ST3GAL3, TKT, TK1, ACSL6
5	female pregnancy	GO:007565	11.4	PSG9, CSH1, PGF, ADM, PSG1, OXTR
6	transcription initiation from RNA polymerase II promoter	GO:006367	11.3	NR0B1, NR3C2, NR4A1, NR5A1, SMAD3, NOTCH1
7	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	11.0	MAPK1, JAK2, IRS1, CSH1, STAT1, GH2
8	response to lipopolysaccharide	GO:032496	11.0	ALPL, GCH1, THBD, CASP8, ADM, EDNRA
9	heart development	GO:007507	11.0	TGFBR1, NOTCH1, EPOR, ADM, OXTR, PDGFB
10	positive regulation of MAPK cascade	GO:043410	11.0	LIF, SOX2, PDGFA, PDGFB, LEP, FLT1
11	response to organic cyclic compound	GO:014070	10.9	RXRA, NOS3, ICAM1, CDKN1A, JUN, RPS6KB1
12	wound healing	GO:042060	10.9	FGF7, INS, IL1B, ERBB3, SMAD3, PDGFA
13	response to cytokine stimulus	GO:034097	10.8	JUN, IL6R, NOS3, TIMP1, IL6ST, LIFR
14	peptidyl-tyrosine phosphorylation	GO:018108	10.8	FLT1, EGF, JAK1, JAK2, INSR, FGFR2
15	lung alveolus development	GO:048286	10.7	WNT5A, SOX2, PDGFA, HOPX, MAN2A1, FGFR2
16	lactation	GO:007595	10.7	SLC29A2, SLC6A3, VDR, OXTR, CAV1, STAT5A
17	angiogenesis	GO:001525	10.7	PTEN, TGFA, PGF, NOS3, PDGFA, EGF
18	response to peptide hormone stimulus	GO:043434	10.6	OXTR, STAT1, OXT, GJA1, STS, NR0B1
19	positive regulation of cell migration	GO:030335	10.6	SMAD3, INSR, NOTCH1, CGA, INS, FLT1
20	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.6	IL6R, FGF7, INS, JAK2, MTOR, LIF
21	response to estradiol stimulus	GO:032355	10.2	TGFB1, AHR, STAT3, OXT, OXTR, SLC6A4
22	phosphatidylinositol-mediated signaling	GO:048015	10.2	PCNA, RPS6KB1, PIK3CB, MTOR, CDKN1B, IRS1
23	positive regulation of cell division	GO:051781	10.2	FGF4, FGF7, FGFR2, APC, PGF, IL1B
24	positive regulation of cell proliferation	GO:008284	10.1	PTEN, MYC, RARA, LIF, LIFR, LEP
25	organ regeneration	GO:031100	10.0	AFP, LIF, LIFR, CDKN1A, MKI67, APOH
26	aging	GO:007568	10.0	EDNRA, TIMP1, TIMP3, ADM, SLC6A3, RXRA
27	interferon-gamma-mediated signaling pathway	GO:060333	10.0	IRF1, JAK2, JAK1, PML, HLA-G, IFNG
28	positive regulation of DNA replication	GO:045740	10.0	JUN, IGF1, INS, CALR, PDGFA, PDGFB
29	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.9	ESR2, TP53, MYC, KCNIP3, STAT3, NOTCH1
30	cytokine-mediated signaling pathway	GO:019221	9.8	KLF6, HLA-G, PTPN11, EDN2, STAT3, STAT5A
31	virus-host interaction	GO:019048	9.8	PML, TGFB1, STAT1, TRIM22, HLA-C, CAV1
32	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	F2, IGF1, FLT1, INS, CAT, GH1
33	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	TNF, IL6R, PDGFB, HIF1A, FLT1, RPS6KB1
34	transforming growth factor beta receptor signaling pathway	GO:007179	9.7	PML, TGIF1, TGFBR1, TGFB1, PDGFB, CREB1
35	response to glucocorticoid stimulus	GO:051384	9.7	ADM, CAV1, HSD11B2, ALPL, IL1B, INSR
36	positive regulation of MAP kinase activity	GO:043406	9.4	FLT1, HTR2A, PDGFB, PDGFA, TNF, TGFB1
37	response to vitamin D	GO:033280	9.4	ALPL, CYP27B1, SPP1, RXRA, TGFB1, INSR
38	positive regulation of mitosis	GO:045840	9.3	EGF, TGFA, INS, INSR, IL1B, IGF2
39	positive regulation of protein kinase B signaling cascade	GO:051897	9.3	IGF1, HPSE, AKR1C3, TNF, PDGFA, TGFB1
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.2	IL1B, ENG, MAF, IGF1, IL17A, FGFR2
41	induction of apoptosis	GO:006917	9.0	FASLG, MAPK1, CASP10, CASP4, TNF, PTEN
42	positive regulation of transcription, DNA-dependent	GO:045893	9.0	FOS, CDKN1C, JUN, RARA, MYC, KLF6
43	negative regulation of transcription, DNA-dependent	GO:045892	8.9	IRF1, CALR, TP53, VDR, CDKN1C, CDKN1B
44	response to drug	GO:042493	8.9	TGFB1, TGFA, TIMP4, ABCG2, TGIF1, STAT3
45	cell cycle arrest	GO:007050	8.8	SMAD3, TGFBR1, SOX2, TGFB1, CDKN3, PML
46	cellular response to organic cyclic compound	GO:071407	8.7	LGALS1, TGFB1, CDKN1B, IL1B, ALPL, PPARG
47	response to hypoxia	GO:001666	8.7	PAM, LEP, ASCL2, FLT1, IL1B, ENG
48	negative regulation of apoptotic process	GO:043066	8.6	MAPK8, TP53, CSF2, TFAP2A, CAT, PTEN
49	negative regulation of cell proliferation	GO:008285	8.6	ADM, TGIF1, TFAP2A, OSM, POU1F1, PML
50	blood coagulation	GO:007596	7.8	NOS2, HGF, HNF4A, CAV1, ALB, F2

Molecular functions related to choriocarcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding transcription factor activity	GO:003700	11.9	TRIM22, GCM1, KLF6, ZNF117, ZNF71, VDR
2	sequence-specific DNA binding	GO:043565	11.7	TGIF1, AHR, HIF1A, HIC1, ELK1, NFE2L3
3	hormone activity	GO:005179	11.5	GH1, GH2, CRH, EDN2, CSH1, CSHL1
4	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	11.2	RORA, STAT3, AHR, RXRA, NR5A1, NR4A1
5	steroid hormone receptor activity	GO:003707	11.0	NR4A1, NR5A1, RXRA, RORA, PGR, NR3C2
6	double-stranded DNA binding	GO:003690	11.0	SMAD3, CREB1, RXRA, STAT5A, STAT1, NR5A1
7	protein homodimerization activity	GO:042803	10.9	TGFB1, TKT, ACSL6, ABCG2, PDGFB, PDGFA
8	receptor binding	GO:005102	10.4	CRAT, CTNND1, HLA-G, HNF4A, CRH, NOS2
9	insulin-like growth factor receptor binding	GO:005159	10.3	IGF1, IGF2, INSR, INSL4, INS, IRS1
10	transcription factor binding	GO:008134	9.9	SMAD3, CREBBP, HIF1A, AHR, STAT3, EBF4
11	protein heterodimerization activity	GO:046982	9.7	PDGFA, PDGFB, HIF1A, AHR, TGFB1, PML
12	transcription regulatory region DNA binding	GO:044212	9.5	HIF1A, AHR, TFAP2A, STAT3, SOX2, WNT5A
13	growth factor activity	GO:008083	9.3	HGF, F2, IGF1, IGF2, ENDOU, IL1B
14	enzyme binding	GO:019899	9.2	NOTCH1, RXRA, ACSL6, HIF1A, TGFB1, STAT1
15	protein binding	GO:005515	8.9	GAPDH, EPOR, HGF, HDAC2, ADM, PGRMC1
16	cytokine activity	GO:005125	8.6	SPP1, OSM, CSF1, CSF2, CSF3, WNT5A