MCID: CHR078
MIFTS: 40

Chorioretinitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Chorioretinitis

Aliases & Descriptions for Chorioretinitis:

Name: Chorioretinitis 12 50 52 42 14 69
Retinochoroiditis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:8886
ICD10 33 H30 H30.9
ICD9CM 35 363.20
MeSH 42 D002825
NCIt 47 C110923
UMLS 69 C0008513

Summaries for Chorioretinitis

MalaCards based summary : Chorioretinitis, also known as retinochoroiditis, is related to syphilis and uveitis, and has symptoms including eye manifestations An important gene associated with Chorioretinitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Dexamethasone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and liver, and related phenotype is nervous system.

Wikipedia : 71 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Chorioretinitis

Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
id Related Disease Score Top Affiliating Genes
1 syphilis 30.2 CD40LG CD79A
2 uveitis 30.2 CD40LG CD79A
3 megacolon 29.4 CD40LG CD79A
4 retinochoroidal coloboma 12.2
5 pigmented paravenous chorioretinal atrophy 12.2
6 microcornea, myopic chorioretinal atrophy, and telecanthus 12.2
7 chorioretinal atrophy, progressive bifocal 12.1
8 focal chorioretinitis 12.0
9 chorioretinal scar 12.0
10 aicardi syndrome 11.9
11 disseminated chorioretinitis 11.9
12 peripheral focal chorioretinitis 11.8
13 boucher-neuhauser syndrome 11.7
14 cleft lower lip cleft lateral canthi chorioretinal 11.7
15 sveinsson choreoretinal atrophy 11.6
16 birdshot chorioretinopathy 11.5
17 choroiditis 11.3
18 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 11.1
19 choroideremia 11.1
20 ataxia - hypogonadism - choroidal dystrophy 11.0
21 gyrate atrophy of choroid and retina with or without ornithinemia 11.0
22 wagner syndrome 1 11.0
23 oliver-mcfarlane syndrome 10.9
24 retinal degeneration, late-onset, autosomal dominant 10.9
25 microcephaly and chorioretinopathy, autosomal recessive, 1 10.8
26 joubert syndrome with oculorenal anomalies 10.8
27 noble bass sherman syndrome 10.8
28 microcephaly and chorioretinopathy, autosomal recessive, 3 10.8
29 cone-rod dystrophy 10.8
30 retinitis 10.7
31 maumenee syndrome 10.7
32 hypomagnesemia 5, renal, with ocular involvement 10.7
33 stickler syndrome, type ii 10.7
34 aicardi-goutieres syndrome 1, dominant and recessive 10.7
35 stickler syndrome, type iv 10.7
36 stickler syndrome, type i 10.7
37 optic disc anomalies with retinal and/or macular dystrophy 10.7
38 linear skin defects with multiple congenital anomalies 1 10.7
39 microcephaly and chorioretinopathy 3 10.7
40 retinal dystrophy with or without extraocular anomalies 10.7
41 vogt-koyanagi-harada disease 10.3
42 peroxisome biogenesis disorder 4b 10.3 CD40LG SAG
43 diabetic peripheral angiopathy 10.3 CD40LG MRAP
44 angiolipoma 10.3 CD40LG MRAP
45 plasmodium falciparum malaria 10.3 CD40LG MRAP
46 hypopituitarism 10.3 CD40LG MRAP
47 parametritis 10.2 RBP3 SAG
48 alcoholic neuropathy 10.2 CD40LG CD79A
49 camptodactyly vertebral fusion 10.2 CD40LG CD79A
50 spinal polio 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Chorioretinitis:



Diseases related to Chorioretinitis

Symptoms & Phenotypes for Chorioretinitis

UMLS symptoms related to Chorioretinitis:


eye manifestations

MGI Mouse Phenotypes related to Chorioretinitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 SRCIN1 CD40LG CD79A CD8A RBP3 SAG

Drugs & Therapeutics for Chorioretinitis

Drugs for Chorioretinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3
Sulfadiazine Approved, Vet_approved Phase 3 68-35-9 5215
4
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
5
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
6
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
7
Sulfamethoxazole Approved Phase 3 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
9
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
11 Prednisolone acetate Phase 3
12 Dexamethasone acetate Phase 3 1177-87-3
13 glucocorticoids Phase 3,Phase 2
14
protease inhibitors Phase 3
15 Folic Acid Antagonists Phase 3
16 Clindamycin palmitate Phase 3
17 Clindamycin phosphate Phase 3
18 Gastrointestinal Agents Phase 3
19 Neuroprotective Agents Phase 3
20 HIV Protease Inhibitors Phase 3
21 Hormone Antagonists Phase 3,Phase 1,Phase 2
22 Dexamethasone 21-phosphate Phase 3
23 Hormones Phase 3,Phase 1,Phase 2
24 Peripheral Nervous System Agents Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
26 Vitamin B Complex Phase 3
27 Anti-Bacterial Agents Phase 3
28 Prednisolone hemisuccinate Phase 3
29 Prednisolone phosphate Phase 3
30 Anti-Infective Agents Phase 3,Phase 2
31 Protective Agents Phase 3
32 Antiemetics Phase 3
33 Anti-Inflammatory Agents Phase 3,Phase 2
34 Antimalarials Phase 3
35 Methylprednisolone acetate Phase 3
36 Methylprednisolone Hemisuccinate Phase 3
37 BB 1101 Phase 3
38 Autonomic Agents Phase 3
39 Antineoplastic Agents, Hormonal Phase 3,Phase 2
40 Antiparasitic Agents Phase 3
41 Antiprotozoal Agents Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
44 Renal Agents Phase 3
45 Immunoglobulin G Phase 3
46 Immunoglobulins Phase 3
47 gamma-Globulins Phase 3
48 Immunoglobulins, Intravenous Phase 3
49 Rho(D) Immune Globulin Phase 3
50 Antibodies Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
2 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
3 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3
4 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3
5 Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis Completed NCT01552044 Phase 1, Phase 2
6 Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a Completed NCT00508040 Phase 2
7 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
8 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
9 Study of the Choroidal Thickness Variations After Ingestion of RedBull® Energy Drink Completed NCT02856256
10 Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Withdrawn NCT01151462

Search NIH Clinical Center for Chorioretinitis

Cochrane evidence based reviews: chorioretinitis

Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

MalaCards organs/tissues related to Chorioretinitis:

39
Retina, Eye, Liver, Testes, B Cells, Brain, Spinal Cord

Publications for Chorioretinitis

Articles related to Chorioretinitis:

(show top 50) (show all 488)
id Title Authors Year
1
Toxoplasmosis with chorioretinitis in an HIV-infected child with no visual complaints-importance of fundus examination. ( 28058107 )
2017
2
SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CHORIORETINAL CHANGES IN HYPERTENSIVE CHOROIDOPATHY RELATED TO HELLP SYNDROME. ( 28067720 )
2017
3
SURGICAL OUTCOMES AND COMPLICATIONS OF RHEGMATOGENOUS RETINAL DETACHMENT IN EYES WITH CHORIORETINAL COLOBOMA: The Results of the KKESH International Collaborative Retina Study Group. ( 28067725 )
2017
4
Syphilitic posterior placoid chorioretinitis as initial presentation of early neurosyphilis. ( 27956326 )
2016
5
En Face: Disappearing Outer Retinal Dots in Treated Syphilitic Chorioretinitis. ( 26902563 )
2016
6
Bilateral Chorioretinitis as Syphilis Presentation: Multimodal Characterization and Therapy Response. ( 27790481 )
2016
7
Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography. ( 27599125 )
2016
8
BIRDSHOT CHORIORETINITIS LESIONS ON INDOCYANINE GREEN ANGIOGRAPHY AS AN INDICATOR OF DISEASE ACTIVITY. ( 26977742 )
2016
9
Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography. ( 27082105 )
2016
10
Sleep Mask-like Chorioretinal Atrophy in a Patient With Alagille Syndrome. ( 27858950 )
2016
11
Toxoplasma chorioretinitis following renal transplantation. ( 26880467 )
2016
12
Effects of PUFAs in a Mouse Model of HSV-1 Chorioretinitis. ( 27438625 )
2016
13
Post-prophylaxis Toxoplasma chorioretinitis following donor-recipient mismatched liver transplantation. ( 27500398 )
2016
14
TECHNIQUE OF LASER CHORIORETINAL ANASTOMOSIS CREATION IN CENTRAL RETINAL VEIN OCCLUSION AND SUCCESS RATE WITH A NEW PHOTOCOAGULATOR SYSTEM. ( 26991650 )
2016
15
CHORIORETINAL WHITE DOT LESIONS IN EYES WITH MULTIFOCAL CHOROIDITIS AND TILTED DISK SYNDROME WITH INFERIOR STAPHYLOMA. ( 27380431 )
2016
16
Cataract, strabismus and chorioretinal coloboma in paediatric HIV infection. ( 27956343 )
2016
17
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS. ( 27880741 )
2016
18
Severe acute syphilitic posterior placoid chorioretinitis with complete spontaneous resolution: The natural course. ( 27625961 )
2016
19
Syphilitic placoid chorioretinitis. A case-report. ( 26920946 )
2016
20
Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient. ( 27340116 )
2016
21
Bilateral optic nerve head drusen with chorioretinal coloboma in the right eye. ( 27099847 )
2016
22
Histiocytic chorioretinitis in a dog. ( 27520710 )
2016
23
Chorioretinal Lesions in a Case of Melanoma-Associated Retinopathy Treated With Pembrolizumab. ( 27540851 )
2016
24
Bilateral papillitis and unilateral focal chorioretinitis as the presenting features of syphilis. ( 26069511 )
2015
25
Spectral domain optical coherence tomography imaging of tubercular chorioretinitis and intraretinal granuloma. Intraretinal tuberculosis: a case report. ( 25813375 )
2015
26
Enhanced Depth Imaging Optical Coherence Tomography of Endogenous Fungal Chorioretinitis. ( 26562514 )
2015
27
Primary silicone oil tamponade and internal limiting membrane peeling for retinal detachment due to macular hole in highly myopic eyes with chorioretinal atrophy. ( 26560878 )
2015
28
Toxoplasma Chorioretinitis Subsequent to Anti-tumour Necrosis Factor Alpha Treatment in a Patient with Ankylosing Spondylitis. ( 26360697 )
2015
29
Long-term visual prognosis of peripheral multifocal chorioretinitis. ( 25595670 )
2015
30
First case of neurofibromatosis type 1 associated with chorioretinal coloboma, optic disc pseudodoubling, and vitiligo: linked pathogenesis? ( 26565699 )
2015
31
Clinical manifestations of syphilitic chorioretinitis: a retrospective study. ( 26064397 )
2015
32
Paradoxical worsening of tuberculous chorioretinitis in a Chinese gentleman. ( 26180557 )
2015
33
Chorioretinal scars and visual deprivation are common in children with cochlear implants after congenital cytomegalovirus infection. ( 25727729 )
2015
34
Traumatic transection of the lateral rectus muscle with chorioretinitis sclopetaria. ( 25790075 )
2015
35
CHORIORETINAL ATROPHY IN ALAGILLE SYNDROME. ( 26355821 )
2015
36
Early resolved acute syphilitic posterior placoid chorioretinitis. ( 25738839 )
2015
37
Helicoid peripapillary chorioretinal degeneration complicated by choroidal neovascularization. ( 26541114 )
2015
38
Multifocal chorioretinitis with progressive subretinal fibrosis in a young child. ( 26468224 )
2015
39
Multimodal imaging of refractory Candida chorioretinitis progressing to endogenous endophthalmitis. ( 26253239 )
2015
40
Spectral-domain optical coherence tomography features of bilateral chorioretinitis sclopetaria. ( 25707053 )
2015
41
Toxocara polymerase chain reaction on ocular fluids in bilateral granulomatous chorioretinitis. ( 26056495 )
2015
42
Toxoplasma chorioretinitis diagnosed by histopathology in a patient with AIDS. ( 25621872 )
2015
43
Atypical chorioretinal coloboma in a Golden Retriever: a retinographic, fluoroangiographic, and optical coherence tomography study. ( 26559650 )
2015
44
Natural course of untreated acute syphilitic posterior placoid chorioretinitis. ( 26566697 )
2015
45
The Role of Chorioretinal Biopsy in the Diagnosis of Intraocular Lymphoma. ( 26344582 )
2015
46
Sequential spontaneous resolution of acute syphilitic posterior placoid chorioretinitis. ( 25449637 )
2015
47
PROSPECTIVE TRIAL OF ENDOGENOUS FUNGAL ENDOPHTHALMITIS AND CHORIORETINITIS RATES, CLINICAL COURSE, AND OUTCOMES IN PATIENTS WITH FUNGEMIA. ( 26655621 )
2015
48
Reversal of Severe Visual Loss from Syphilitic Chorioretinitis Following Penicillin Treatment. ( 27928366 )
2015
49
Chorioretinitis with exudative retinal detachment secondary to varicella zoster virus. ( 26455991 )
2015
50
Multifocal chorioretinitis caused by Bartonella henselae: imaging findings of spectral domain optical coherence tomography during treatment with trimethoprim-sulfamethoxazole. ( 24763244 )
2014

Variations for Chorioretinitis

Expression for Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for Chorioretinitis

Pathways related to Chorioretinitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.37 CD40LG CD79A CD8A

GO Terms for Chorioretinitis

Cellular components related to Chorioretinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD40LG CD79A CD8A

Biological processes related to Chorioretinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.13 CD79A CD8A SAG
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Chorioretinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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