Chorioretinitis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Chorioretinitis

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

MalaCards: Chorioretinitis, also known as other and unspecified forms of chorioretinitis and retinochoroiditis, is related to retinitis and chorioretinal scar. An important gene associated with Chorioretinitis is TEAD1 (TEA domain family member 1 (SV40 transcriptional enhancer factor)), and among its related pathways are the visual cycle I (vertebrates) and Visual phototransduction. The compounds 11-cis-retinol and copper have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and liver, and related mouse phenotypes are pigmentation and homeostasis/metabolism.

Aliases & Classifications for Chorioretinitis

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ²⁷ICD9CM, ³⁴MeSH
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Aliases & Descriptions:

chorioretinitis ⁸ ⁴² ¹⁰ ⁴⁴ ⁶⁰

other and unspecified forms of chorioretinitis and retinochoroiditis ⁸

other chorioretinitis and retinochoroiditis ⁸

retinochoroiditis nos disorder ⁸

retinitis and chorioretinitis ⁸

chorioretinitis, unspecified ⁸

other chorioretinitis ⁸

retinochoroiditis ⁸

External Ids:

Disease Ontology⁸ DOID:8886

ICD9CM²⁷ 363.20

SNOMED-CT⁵⁶ 270531006, 193432007, 46627006

MeSH³⁴ D002825

UMLS⁶⁰ C0008513

Related Diseases for Chorioretinitis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 237)

id	Related Disease	Score	Top Affiliating Genes
1	retinitis	30.8	SAG
2	chorioretinal scar	30.5	JMJD6
3	uveitis	30.4	RBP3, SAG
4	night blindness	30.2	SAG, RPE65
5	cone-rod dystrophy 2	29.9	PRPH2, RPE65
6	gyrate atrophy	29.6	OAT
7	retinal disease	29.6	RPE65, ROM1, SAG, CRB1, RBP3, PRPH2
8	toxoplasmosis	10.5
9	aicardi syndrome	10.4
10	central retinal vein occlusion	10.4
11	retinal vein occlusion	10.4
12	coloboma	10.3
13	microcephaly	10.3
14	progressive bifocal chorioretinal atrophy	10.3
15	disseminated chorioretinitis	10.3
16	choroiditis	10.3
17	retinochoroidal coloboma	10.3
18	focal chorioretinitis	10.3
19	congenital toxoplasmosis	10.2
20	retinal detachment	10.2
21	syphilis	10.2
22	subacute sclerosing panencephalitis	10.2
23	encephalitis	10.2
24	herpes simplex	10.2
25	peripheral focal chorioretinitis	10.1
26	keratitis	10.1
27	lymphedema	10.1
28	tuberculosis	10.1
29	pigmented paravenous chorioretinal atrophy	10.1
30	chronic granulomatous disease	10.1
31	lymphocytic choriomeningitis	10.1
32	onchocerciasis	10.1
33	panuveitis	10.1
34	neuroretinitis	10.0
35	macular retinal edema	10.0
36	vogt-koyanagi-harada disease	10.0
37	joubert syndrome	10.0
38	arthritis	10.0
39	histoplasmosis	10.0
40	myopia	10.0
41	neuritis	10.0
42	optic neuritis	10.0
43	joubert syndrome with oculorenal anomalies	10.0
44	birdshot chorioretinopathy	10.0
45	lymphedema, microcephaly and chorioretinopathy syndrome	10.0
46	cleft lower lip cleft lateral canthi chorioretinal	10.0
47	wagner syndrome	10.0
48	sveinsson choreoretinal atrophy	10.0
49	microcornea, myopic chorioretinal atrophy, and telecanthus	10.0
50	peripheral retinal degeneration	10.0	ROM1

Graphical network of the top 20 diseases related to Chorioretinitis:

Clinical Features for Chorioretinitis

Drugs & Therapeutics for Chorioretinitis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

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³²MalaCards
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MalaCards organs/tissues related to Chorioretinitis:

³²

Retina, Eye, Liver, Brain, Spinal cord, Kidney, Testes, B cells

Animal Models for Chorioretinitis or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Chorioretinitis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	9.4	PRPH2, CRB1, FOXC1, C1QTNF5, RPE65, OAT
2	homeostasis/metabolism phenotype	MP:0005376	8.8	OAT, JMJD6, FOXC1, CRB1, MT2A, MT3
3	vision/eye phenotype	MP:0005391	8.7	PRPH2, C1QTNF5, OAT, ROM1, RPE65, JMJD6
4	cardiovascular system phenotype	MP:0005385	8.7	ROM1, CX3CL1, HCCS, PRPH2, MT2A, JMJD6
5	nervous system phenotype	MP:0003631	8.0	CX3CL1, PRPH2, MT3, MT2A, RBP3, CRB1

Publications for Chorioretinitis

Sources:
⁵⁰PubMed
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Articles related to Chorioretinitis:

(show top 50) (show all 407)

id	Title	Authors	Year
1	Syphilitic posterior placoid chorioretinitis. (24113406)	Gorovoy I.R.... Desai S.	2013
2	Pigmented paravenous chorioretinal atrophy with Coat's like response. (24212310)	Tandon M.... Ramasamy K.	2013
3	Early Autofluorescence Findings of Relentless Placoid Chorioretinitis. (24008837)	Veronese C.... Ciardella A.P.	2013
4	Vascular remodeling in central retinal vein occlusion following laser-induced chorioretinal anastomosis. (23494049)	Cohen S.M.	2013
5	Molecular identification of bacterial DNA in the chorioretinal scars of chronic granulomatous disease. (23636897)	Wang Y.... Chan C.C.	2013
6	TINU (Tubulointerstitial Nephritis Uveitis) Can Be Associated with Chorioretinal Scars. (24143861)	Ali A.... Rosenbaum J.T.	2013
7	Unusual presentation of ocular tuberculosis: multiple chorioretinitis, retinal vasculitis and ischaemic central retinal vein occlusion. (23931632)	Yuksel E.... Ozdek S.	2013
8	Microcephaly, lymphedema, chorioretinal dysplasia (MLCRD) syndrome. (22726716)	Kelly M.N.... Tuli S.	2012
9	Chancre of the eyelid as manifestation of primary syphilis, and precocious chorioretinitis and uveitis in an HIV-infected patient: a case report. (23006858)	Cillino S.... Di Carlo P.	2012
10	Bilateral, geographic, peripapillary, chorioretinal atrophy in a patient with porphyria cutanea tarda and high iron stores. (21775216)	Denton W.J.... McGill W.J.	2011
11	Is a 6-week course of ganciclovir therapy effective for chorioretinitis in infants with congenital cytomegalovirus infection? (20400108)	Shoji K.... Saitoh A.	2010
12	Cryptococcal chorioretinitis with immune reconstitution inflammatory syndrome. (19831560)	Shulman J.... Sanjana V.	2009
13	Acute acquired toxoplasmosis presenting as polymyositis and chorioretinitis in immunocompetent patient. (18406191)	Hassene A.... Series C.	2008
14	Optical coherence tomography in relentless placoid chorioretinitis. (18700930)	Amer R.... Florescu T.	2008
15	Identification of Pseudomonas aeruginosa DNA in a chorioretinal lesion associated with chronic granulomatous disease. (18755713)	Herzlich A.A.... Chan C.	2008
16	Varicella chorioretinitis. (18028120)	Aslan O.... Ozkan S.S.	2007
17	Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)	Chen C.H.... Kuo H.K.	2005
18	A young Japanese man with relentless placoid chorioretinitis. (16365808)	Orihara T.... Hida T.	2005
19	Meningococcal group B meningitis associated with a focal chorioretinitis. (15731773)	Rathod D.... Heath J.D.	2005
20	Microcephaly-lymphoedema-chorioretinal-dysplasia syndrome with atrial septal defect. (16060885)	Strauss R.M.... Cork M.J.	2005
21	Chorioretinal scar growth after 810-nanometer laser treatment for retinoblastoma. (15121379)	Lee T.C.... Abramson D.H.	2004
22	West Nile virus chorioretinitis. (15548822)	Shaikh S.... Trese M.T.	2004
23	Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. (14605902)	Coupland S.E.... Stein H.	2003
24	Recovery of visual function in a patient with birdshot chorioretinitis. (12714425)	Dolan F.M.... Keating D.	2003
25	Chorioretinal anastomosis probably occurs infrequently in type 2A idiopathic juxtafoveolar retinal telangiectasis. (12963631)	Gass J.D.	2003
26	PCR-aided diagnosis of fungal chorioretinitis following ingestion of traditional Chinese medication. (12476112)	Cheng C.L.... Chan T.K.	2002
27	Expression of metallothionein isoforms in human chorioretinal complex. (12187490)	Tate D.J.... Newsome D.A.	2002
28	Clinical picture: tuberculous chorioretinitis. (11356435)	Lanzafame M.... Parrinello A.	2001
29	Experimental reproduction of viral chorioretinitis in kangaroos. (10494399)	Reddacliff L.... Hyatt A.	1999
30	Overt chorioretinitis after patient acquired toxoplasmosis in an immunocompetent subject. (9930284)	Marx-Chemla C.... Ducasse A.	1998
31	Chorioretinitis secondary to mycobacterium tuberculosis in acquired immune deficiency syndrome. (9355193)	Recillas-Gispert C.... Sada-DA-az E.	1997
32	The pathogenesis of chorioretinal disease in onchocerciasis. (15275111)	Cooper P.J.... Taylor D.W.	1997
33	Necrotizing chorioretinitis in mice inoculated with herpes simplex virus type 1 with or without glycoprotein C: anterior chamber-associated immune deviation does not persist. (8397500)	Liu Y.... Mori R.	1993
34	Two cases of acquired syphilis with acute central chorioretinitis as initial manifestation. (1464969)	Yagasaki T.... Awaya S.	1992
35	Experimental ocular onchocerciasis in cynomolgus monkeys. IV. Chorioretinitis elicited by Onchocerca volvulus microfilariae. (2016131)	Semba R.D.... Taylor H.R.	1991
36	Vitrectomy for epiretinal membrane with Candida chorioretinitis. (2326025)	McDonald H.R.... Sipperley J.O.	1990
37	Chorioretinitis induced by coxsackievirus B4 infection. (2154107)	Hirakata K.... Azuma N.	1990
38	Multifocal serous chorioretinitis in beagle dogs. (2100187)	von Landenberg F.... Metallinos A.	1990
39	Bilateral chorioretinitis, centripetal optic neuritis, and encephalitis in a llama. (2722665)	Paulsen M.E.... Severin G.A.	1989
40	Disseminated bilateral chorioretinitis due to Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome. (2413418)	Macher A.... Reichert C.M.	1985
41	Specific diagnosis of toxoplasmic chorioretinitis by demonstration of intraocular toxoplasma IgG antibodies. (3983163)	Leinikki P.O.... Saari K.M.	1985
42	Tears of the retinal pigment epithelium. Occurrence in retinal detachments and a chorioretinal scar. (6463397)	Swanson D.E.... Guzak S.V.	1984
43	Further delineation of the Cohen syndrome; report on chorioretinal dystrophy, leukopenia and consanguinity. (6705238)	Norio R.... Lindahl E.	1984
44	Metastatic fungal chorioretinitis developing during Trichosporon sepsis. (6951137)	Walsh T.J.... Keller J.L.	1982
45	Cyclitis and peripheral chorioretinitis. (13908214)	Hogan M.J.... Kimura S.J.	1961
46	Probable toxoplasmic chorioretinitis. (13050681)	KOKE M.P.	1953
47	Contribution to the chorioretinitis centralis serosa Kitahara. (14827511)	CZUKRASZ I.	1951
48	Central chorioretinitis. (18146136)	STINE G.H.... CHAPMAN K.H.	1949
49	Chorioretinitis juxtapapillaris, Jensen's disease. (18870553)	BULLWINKEL H.G.	1948
50	Probable toxoplasmal chorioretinitis. (20341582)	RYERSON F.S.	1947

Genes related to Chorioretinitis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Chorioretinitis:

(show all 32)

id	Symbol	Description	Score	Implication
1	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	20.39	GeneCards inferred : Publications, Disorders, Gene name, Summaries (show sections)
2	CLDN19	claudin 19	19.73	GeneCards inferred : Disorders, Summaries (show sections)
3	CRB1	crumbs homolog 1 (Drosophila)	19.07	GeneCards inferred : Publications, Disorders (show sections)
4	RBP3	retinol binding protein 3, interstitial	18.43	GeneCards inferred : Disorders (show sections)
5	SAG	S-antigen; retina and pineal gland (arrestin)	17.81	GeneCards inferred : Disorders (show sections)
6	ROM1	retinal outer segment membrane protein 1	17.17	GeneCards inferred : Publications, Disorders (show sections)
7	HCCS	holocytochrome c synthase	16.54	GeneCards inferred : Disorders (show sections)
8	C1QTNF5	C1q and tumor necrosis factor related protein 5	15.92	GeneCards inferred : Disorders (show sections)
9	MT2A	metallothionein 2A	15.29	GeneCards inferred : Publications, Disorders (show sections)
10	PRRT2	proline-rich transmembrane protein 2	14.67	GeneCards inferred : Disorders (show sections)
11	FOXC1	forkhead box C1	14.04	GeneCards inferred : Publications, Disorders (show sections)
12	PRPH2	peripherin 2 (retinal degeneration, slow)	13.42	GeneCards inferred : Publications, Disorders (show sections)
13	RPE65	retinal pigment epithelium-specific protein 65kDa	12.79	GeneCards inferred : Disorders (show sections)
14	OAT	ornithine aminotransferase	12.17	GeneCards inferred : Publications, Disorders (show sections)
15	PBCRA1	progressive bifocal chorioretinal atrophy 1	11.60	GeneCards inferred : Publications, Disorders, Gene name (show sections)
16	JMJD6	jumonji domain containing 6	10.93	GeneCards inferred : Disorders (show sections)
17	CX3CL1	chemokine (C-X3-C motif) ligand 1	10.31	GeneCards inferred : Disorders (show sections)
18	IMPG1	interphotoreceptor matrix proteoglycan 1	9.68	GeneCards inferred : Publications, Disorders (show sections)
19	MT3	metallothionein 3	9.04	GeneCards inferred : Publications, Disorders (show sections)
20	AOC2	amine oxidase, copper containing 2 (retina-specific)	8.42	GeneCards inferred : Disorders (show sections)
21	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	7.79	GeneCards inferred : Publications, Disorders (show sections)
22	PAX6	paired box 6	7.17	GeneCards inferred : Publications, Disorders (show sections)
23	COL2A1	collagen, type II, alpha 1	6.54	GeneCards inferred : Publications, Disorders (show sections)
24	RHO	rhodopsin	5.92	GeneCards inferred : Publications, Disorders (show sections)
25	COL9A1	collagen, type IX, alpha 1	5.29	GeneCards inferred : Disorders (show sections)
26	CHM	choroideremia (Rab escort protein 1)	4.67	GeneCards inferred : Disorders (show sections)
27	TGFA	transforming growth factor, alpha	4.04	GeneCards inferred : Publications, Disorders (show sections)
28	COL11A1	collagen, type XI, alpha 1	3.42	GeneCards inferred : Publications, Disorders (show sections)
29	VCAN	versican	2.79	GeneCards inferred : Disorders (show sections)
30	CD4	CD4 molecule	2.17	GeneCards inferred : Disorders (show sections)
31	IGF2	insulin-like growth factor 2 (somatomedin A)	1.54	GeneCards inferred : Publications, Disorders (show sections)
32	HLA-B	major histocompatibility complex, class I, B	0.92	GeneCards inferred : Disorders (show sections)

Products for genes related to Chorioretinitis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	28	28	31
2	LSBio	-	-	32

Genetic Variations for Chorioretinitis

Expression for genes affiliated with Chorioretinitis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for genes affiliated with Chorioretinitis

Sources:
³⁷NCBI BioSystems Database, ⁵³Reactome, ⁵¹QIAGEN
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Pathways related to Chorioretinitis according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	the visual cycle I (vertebrates)³⁷ Hide members The canonical retinoid cycle in rods (twilight vision)⁵³	10.2	RBP3, RPE65
2	Visual phototransduction⁵³ Hide members Diseases associated with visual transduction⁵³	10.0	RBP3, SAG, RPE65
3	Visual Cycle in Retinal Rods⁵¹	10.0	RBP3, SAG, RPE65