MCID: CHR079
MIFTS: 34

Choroid Disease malady

Categories: Eye diseases

Aliases & Classifications for Choroid Disease

Aliases & Descriptions for Choroid Disease:

Name: Choroid Disease 12 29 14
Choroid Diseases 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1417
ICD10 33 H31.9 H31 H31.8
ICD9CM 35 363.9
MeSH 42 D015862
NCIt 47 C34468
SNOMED-CT 64 193431000 193480005
UMLS 69 C0008521

Summaries for Choroid Disease

MalaCards based summary : Choroid Disease, also known as choroid diseases, is related to agammaglobulinemia, x-linked 1 and fanconi anemia, complementation group l. An important gene associated with Choroid Disease is CHM (CHM, Rab Escort Protein 1), and among its related pathways/superpathways are RAB geranylgeranylation and Arginine and proline metabolism. The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotypes are nervous system and pigmentation

Wikipedia : 71 The choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye, containing... more...

Related Diseases for Choroid Disease

Graphical network of the top 20 diseases related to Choroid Disease:



Diseases related to Choroid Disease

Symptoms & Phenotypes for Choroid Disease

MGI Mouse Phenotypes related to Choroid Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 CHM CNGB3 NDP OAT POU3F4 RAB27A
2 pigmentation MP:0001186 9.35 CHM NDP OAT RAB27A RS1
3 vision/eye MP:0005391 9.1 CHM CNGB3 NDP OAT RAB27A RS1

Drugs & Therapeutics for Choroid Disease

Drugs for Choroid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 350)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
3
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 129497-78-5
4
Povidone-iodine Approved Phase 4 25655-41-8
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
8
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
9
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
10
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
11
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
12
Travoprost Approved Phase 4 157283-68-6 5282226
13
Eplerenone Approved Phase 4,Phase 2,Phase 3 107724-20-9 150310 443872
14
Spironolactone Approved Phase 4,Phase 2,Phase 3,Phase 1 1952-01-7, 52-01-7 5833
15
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
16
Ofloxacin Approved Phase 4 82419-36-1 4583
17
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
18
Dipivefrin Approved Phase 4 52365-63-6 3105
19
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
20 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
21 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
25 Hormones Phase 4,Phase 2,Phase 3,Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
27 Endothelial Growth Factors Phase 4,Phase 3,Phase 2,Phase 1
28 Mitogens Phase 4,Phase 3,Phase 2,Phase 1
29 cadexomer iodine Phase 4,Phase 2,Phase 1
30
Iodine Phase 4,Phase 2,Phase 1 7553-56-2 807
31 Povidone Phase 4
32 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
33 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
35 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
36 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
37 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
38 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
39 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
42 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
44
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
45 Methylprednisolone acetate Phase 4,Phase 3
46 Methylprednisolone Hemisuccinate Phase 4,Phase 3
47 Neuroprotective Agents Phase 4,Phase 3
48 Prednisolone acetate Phase 4,Phase 3
49 Prednisolone hemisuccinate Phase 4,Phase 3
50 Prednisolone phosphate Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 416)
id Name Status NCT ID Phase
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4
3 Ranibizumab for Myopic Neovascularization Unknown status NCT01246089 Phase 4
4 Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial) Unknown status NCT02092532 Phase 4
5 The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil Completed NCT03144596 Phase 4
6 Intraocular Pressure Immediately Following Intravitreous Injection of Ranibizumab Completed NCT00417703 Phase 4
7 Bevacizumab Intravitreal for Myopic Choroidal Neovascularization Completed NCT00797992 Phase 4
8 Photodynamic Therapy in Occult-Only Lesions (POOL) Completed NCT00135837 Phase 4
9 Macular EpiRetinal Brachytherapy Versus Lucentis® Only Treatment (MERLOT) Completed NCT01006538 Phase 4
10 Efficacy Study of Ranibizumab on Patients With Age-related Macular Degeneration. Completed NCT01831947 Phase 4
11 Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab Completed NCT01810042 Phase 4
12 Comparison of Safety, Effectiveness and Quality of Life Outcomes Between Labeled Versus "Treat and Extend" Regimen in Turkish Patients With Choroidal Neovascularisation Due to Age-related Macular Degeneration (AMD) Completed NCT01148511 Phase 4
13 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
14 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
15 Study to Investigate the Safety and Efficacy of Ranibizumab in Patients With Choroidal Neovascularisation Due to Causes Other Than Age Related Macular Degeneration Completed NCT01628354 Phase 4
16 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4
17 Reduced Fluence Photodynamic Therapy (PDT) With Visudyne in Combination With Lucentis for Age-Related Macular Degeneration Completed NCT00473642 Phase 4
18 PreView PHP Preferential Hyperacuity Perimeter for the Detection of Choroidal Neovascularization Completed NCT00358345 Phase 4
19 Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration Completed NCT00504959 Phase 4
20 Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients Completed NCT00308945 Phase 4
21 Micropulse 577nm Laser vs Traditional Laser Treatment in Central Serous Chorioretinopathy Recruiting NCT02735213 Phase 4
22 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4
23 Efficacy of Aflibercept (Eylea®) on Choroidal Neovascularization (Type 3) Recruiting NCT02320474 Phase 4
24 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4
25 Photodynamic Therapy Versus Eplerenone: Treatment Trial for Chronic Central Serous Chorioretinopathy Recruiting NCT03079141 Phase 4
26 Triamcinolone Injections for Persistent Choroidal Effusions Post Glaucoma Surgery Recruiting NCT02917564 Phase 4
27 Comparison of Treatment Regimens Using Ranibizumab: Intensive (Resolution of Intra- and Sub-retinal Fluid) vs Relaxed (Resolution of Primarily Intra-retinal Fluid) Treatment. Active, not recruiting NCT01972789 Phase 4
28 A Study Of Early Markers Of Choroidal Neovascularization Terminated NCT00902785 Phase 4
29 An Open Label Trial to Investigate Macugen for the Preservation of Visual Function in Subjects With Neovascular AMD Terminated NCT00327470 Phase 4
30 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Withdrawn NCT01666236 Phase 4
31 Treatment Of Radiation Retinopathy Trial Unknown status NCT00811200 Phase 2, Phase 3
32 Off-Label AVASTIN (BEVACIZUMAB) For Serosanguinous Maculopathy Unknown status NCT00344617 Phase 3
33 Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Unknown status NCT00599820 Phase 3
34 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3
35 Double-Masked Study of Photrex (Rostaporfin) Photodynamic Therapy in the Treatment of Age-Related Macular Degeneration Unknown status NCT00157976 Phase 3
36 A Randomized, Double-blind, Multicenter, Sham-controlled, Safety and Efficacy Study of Conbercept in Patients With mCNV Unknown status NCT01809223 Phase 3
37 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
38 Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy, Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization Unknown status NCT00930189 Phase 2, Phase 3
39 TTT Versus PDT for Treatment of Choroidal Neovascularization in Age-Related Macular Degeneration Unknown status NCT00260403 Phase 2, Phase 3
40 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
41 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
42 Avastin for CNV Secondary to Pattern Dystrophy Unknown status NCT00391144 Phase 2, Phase 3
43 Efficacy of Retreatments With Intravitreal Bevacizumab Unknown status NCT00406744 Phase 3
44 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3
45 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3
46 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3
47 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3
48 Assess the Efficacy/Safety of Intravitreal Ranibizumab in Patients With Vision Loss Due to Choroidal Neovascularization. Completed NCT01840410 Phase 3
49 Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment Completed NCT00417833 Phase 2, Phase 3
50 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3

Search NIH Clinical Center for Choroid Disease

Cochrane evidence based reviews: choroid diseases

Genetic Tests for Choroid Disease

Genetic tests related to Choroid Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Choroid 29

Anatomical Context for Choroid Disease

MalaCards organs/tissues related to Choroid Disease:

39
Eye, Retina

Publications for Choroid Disease

Articles related to Choroid Disease:

id Title Authors Year
1
ANGIOID STREAKS, AND THEIR RELATION TO A FORM OF CENTRAL CHOROIDAL DISEASE. ( 18168957 )
1931

Variations for Choroid Disease

Expression for Choroid Disease

Search GEO for disease gene expression data for Choroid Disease.

Pathways for Choroid Disease

Pathways related to Choroid Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.07 CHM RAB27A
2
Show member pathways
10.91 OAT PYCR1
3
Show member pathways
10.57 OAT PYCR1
4
Show member pathways
10 OAT PYCR1

GO Terms for Choroid Disease

Cellular components related to Choroid Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 8.62 CNGB3 RAB27A

Biological processes related to Choroid Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.46 CHM CNGB3 NDP RS1
2 cellular amino acid biosynthetic process GO:0008652 9.26 OAT PYCR1
3 visual perception GO:0007601 9.02 CHM CNGB3 NDP OAT RS1
4 L-proline biosynthetic process GO:0055129 8.96 OAT PYCR1

Sources for Choroid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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