Aliases & Classifications for Choroid Disease

MalaCards integrated aliases for Choroid Disease:

Name: Choroid Disease 12 14
Choroid Diseases 41 69
Abnormality of the Choroid 28

Classifications:



External Ids:

Disease Ontology 12 DOID:1417
ICD10 32 H31.9 H31 H31.8
ICD9CM 34 363.9
MeSH 41 D015862
NCIt 46 C34468
SNOMED-CT 64 193431000 193480005
UMLS 69 C0008521

Summaries for Choroid Disease

MalaCards based summary : Choroid Disease, also known as choroid diseases, is related to cystinuria and red-green color blindness. An important gene associated with Choroid Disease is CHM (CHM, Rab Escort Protein 1), and among its related pathways/superpathways are RAB geranylgeranylation and Arginine and proline metabolism. The drugs Dexamethasone and Iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are nervous system and pigmentation

Wikipedia : 72 The Choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye, containing... more...

Related Diseases for Choroid Disease

Diseases related to Choroid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 cystinuria 10.1 OAT SLC6A18
2 red-green color blindness 10.0 CNGB3 RPE65
3 retinoschisis 1, x-linked, juvenile 10.0 CNGB3 RPE65
4 achromatopsia 3 10.0 CNGB3 RPE65
5 stargardt disease 9.9 CNGB3 RPE65
6 fundus albipunctatus 9.9 RBP3 RPE65
7 achromatopsia 9.8 CNGB3 RPE65
8 cone-rod dystrophy 2 9.6 CNGB3 RPE65
9 angioid streaks 9.5
10 choroiditis 9.5
11 choroideremia 9.3 CHM CNGB3 POU3F4 RAB27A RPE65
12 gyrate atrophy of choroid and retina 9.1 DXO OAT PYCR1 SLC6A18

Graphical network of the top 20 diseases related to Choroid Disease:



Diseases related to Choroid Disease

Symptoms & Phenotypes for Choroid Disease

MGI Mouse Phenotypes related to Choroid Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 OAT POU3F4 RAB27A RBP3 RPE65 CHM
2 pigmentation MP:0001186 9.26 RAB27A RPE65 CHM OAT
3 vision/eye MP:0005391 9.1 RAB27A RBP3 RPE65 CHM CNGB3 OAT

Drugs & Therapeutics for Choroid Disease

Drugs for Choroid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 129497-78-5
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
5
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1 347396-82-1 459903
6
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Povidone Approved Phase 4 9003-39-8
9
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
10
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
11
Ofloxacin Approved Phase 4 82419-36-1 4583
12
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
13
Lactitol Investigational Phase 4 585-86-4 3871
14 triamcinolone acetonide Phase 4,Phase 2,Phase 3,Phase 1
15 cadexomer iodine Phase 4
16 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
17 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
18
protease inhibitors Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Triamcinolone diacetate Phase 4,Phase 2,Phase 3,Phase 1
21 Triamcinolone hexacetonide Phase 4,Phase 2,Phase 3,Phase 1
22 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
23 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
24 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
26 Hormones Phase 4,Phase 2,Phase 3,Phase 1
27 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
30 Antiemetics Phase 4,Phase 3,Phase 2
31 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
34 BB 1101 Phase 4,Phase 3,Phase 2
35 Autonomic Agents Phase 4,Phase 3,Phase 2
36 beta-endorphin Phase 4
37 Adrenergic Agents Phase 4
38 Mitogens Phase 4,Phase 3,Phase 2,Phase 1
39 Adrenergic alpha-1 Receptor Antagonists Phase 4
40 Adrenergic alpha-Antagonists Phase 4
41 Adrenergic Antagonists Phase 4
42 Adrenocorticotropic Hormone Phase 4
43 Neurotransmitter Agents Phase 4
44 Endothelial Growth Factors Phase 4,Phase 3,Phase 2,Phase 1
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
46 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Melanocyte-Stimulating Hormones Phase 4
48 Tetrahydrozoline Phase 4,Phase 2
49 Ophthalmic Solutions Phase 4,Phase 2
50
Mycophenolic acid Approved Phase 3 24280-93-1 446541

Interventional clinical trials:

(show top 50) (show all 245)

# Name Status NCT ID Phase Drugs
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4 Aflibercept Injection
3 Ranibizumab for Myopic Neovascularization Unknown status NCT01246089 Phase 4 ranibizumab injection
4 Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial) Unknown status NCT02092532 Phase 4 Rescue Intravitreal Aflibercept Injection
5 The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil Completed NCT03144596 Phase 4 Alfuzosin Hydrochloride 10 MG;Tamsulosin Hydrochloride 0.4 MG
6 Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification Completed NCT03321253 Phase 4
7 Intraocular Pressure Immediately Following Intravitreous Injection of Ranibizumab Completed NCT00417703 Phase 4
8 Bevacizumab Intravitreal for Myopic Choroidal Neovascularization Completed NCT00797992 Phase 4 Injection
9 SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia Completed NCT03409250 Phase 4 Ranibizumab, Lucentis
10 Time Course of Activity Signs at SD-OCT High Frequency Intravitreal Ranibizumab Treatment in CNV Due to AMD Completed NCT03393767 Phase 4 Ranibizumab
11 Efficacy Study of Ranibizumab on Patients With Age-related Macular Degeneration. Completed NCT01831947 Phase 4
12 Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab Completed NCT01810042 Phase 4 ranibizumab
13 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
14 Macular EpiRetinal Brachytherapy Versus Lucentis® Only Treatment (MERLOT) Completed NCT01006538 Phase 4 Ranibizumab
15 Comparison of Treatment Regimens Using Ranibizumab: Intensive (Resolution of Intra- and Sub-retinal Fluid) vs Relaxed (Resolution of Primarily Intra-retinal Fluid) Treatment. Completed NCT01972789 Phase 4 Ranibizumab
16 Study to Investigate the Safety and Efficacy of Ranibizumab in Patients With Choroidal Neovascularisation Due to Causes Other Than Age Related Macular Degeneration Completed NCT01628354 Phase 4 Ranibizumab
17 Comparison of Safety, Effectiveness and Quality of Life Outcomes Between Labeled Versus "Treat and Extend" Regimen in Turkish Patients With Choroidal Neovascularisation Due to Age-related Macular Degeneration (AMD) Completed NCT01148511 Phase 4 Ranibizumab 0.5 mg
18 Photodynamic Therapy in Occult-Only Lesions (POOL) Completed NCT00135837 Phase 4 Verteporfin for injection
19 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4 ranibizumab
20 Reduced Fluence Photodynamic Therapy (PDT) With Visudyne in Combination With Lucentis for Age-Related Macular Degeneration Completed NCT00473642 Phase 4 Ranibizumab;Verteporfin;Verteporfin
21 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
22 Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration Completed NCT00504959 Phase 4 ranibizumab
23 PreView PHP Preferential Hyperacuity Perimeter for the Detection of Choroidal Neovascularization Completed NCT00358345 Phase 4
24 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4 0.5mg intravitreal ranibizumab
25 Efficacy of Aflibercept (Eylea®) on Choroidal Neovascularization (Type 3) Recruiting NCT02320474 Phase 4 Aflibercept
26 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
27 A Study Of Early Markers Of Choroidal Neovascularization Terminated NCT00902785 Phase 4
28 An Open Label Trial to Investigate Macugen for the Preservation of Visual Function in Subjects With Neovascular AMD Terminated NCT00327470 Phase 4 Pegaptanib Sodium 0.3 mg
29 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Withdrawn NCT01666236 Phase 4
30 Treatment Of Radiation Retinopathy Trial Unknown status NCT00811200 Phase 2, Phase 3 ranibizumab;triamcinolone acetonide
31 Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
32 Off-Label AVASTIN (BEVACIZUMAB) For Serosanguinous Maculopathy Unknown status NCT00344617 Phase 3 Bevacizumab (tradename: Avastin)
33 A Randomized, Double-blind, Multicenter, Sham-controlled, Safety and Efficacy Study of Conbercept in Patients With mCNV Unknown status NCT01809223 Phase 3 conbercept, Fixed;conbercept, PRN
34 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3 ranibizumab
35 Double-Masked Study of Photrex (Rostaporfin) Photodynamic Therapy in the Treatment of Age-Related Macular Degeneration Unknown status NCT00157976 Phase 3 Photrex (rostaporfin)
36 Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy, Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization Unknown status NCT00930189 Phase 2, Phase 3 intravitreal injection of ranibizumab;intravitreal injection of triamcinolone
37 Avastin for CNV Secondary to Pattern Dystrophy Unknown status NCT00391144 Phase 2, Phase 3
38 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
39 Efficacy of Retreatments With Intravitreal Bevacizumab Unknown status NCT00406744 Phase 3 Intravitreal injection of Bevacizumab
40 TTT Versus PDT for Treatment of Choroidal Neovascularization in Age-Related Macular Degeneration Unknown status NCT00260403 Phase 2, Phase 3
41 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
42 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
43 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
44 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
45 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
46 Assess the Efficacy/Safety of Intravitreal Ranibizumab in Patients With Vision Loss Due to Choroidal Neovascularization. Completed NCT01840410 Phase 3 Ranibizumab
47 Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment Completed NCT00417833 Phase 2, Phase 3 Intravitreal Bevacizumab
48 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
49 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
50 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin

Search NIH Clinical Center for Choroid Disease

Cochrane evidence based reviews: choroid diseases

Genetic Tests for Choroid Disease

Genetic tests related to Choroid Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Choroid 28

Anatomical Context for Choroid Disease

MalaCards organs/tissues related to Choroid Disease:

38
Eye, Retina, Endothelial, Testes

Publications for Choroid Disease

Articles related to Choroid Disease:

# Title Authors Year
1
ANGIOID STREAKS, AND THEIR RELATION TO A FORM OF CENTRAL CHOROIDAL DISEASE. ( 18168957 )
1931

Variations for Choroid Disease

Expression for Choroid Disease

Search GEO for disease gene expression data for Choroid Disease.

Pathways for Choroid Disease

GO Terms for Choroid Disease

Cellular components related to Choroid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 8.62 CNGB3 RAB27A

Biological processes related to Choroid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.26 RBP3 RPE65
2 cellular amino acid biosynthetic process GO:0008652 9.16 OAT PYCR1
3 visual perception GO:0007601 9.02 CHM CNGB3 OAT RBP3 RPE65
4 L-proline biosynthetic process GO:0055129 8.96 OAT PYCR1

Sources for Choroid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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