MCID: CHR573
MIFTS: 41

Choroid Plexus Cancer malady

Categories: Rare diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Choroid Plexus Cancer

Aliases & Descriptions for Choroid Plexus Cancer:

Name: Choroid Plexus Cancer 12 14
Choroid Plexus Carcinoma 12 50 42 14 69
Malignant Neoplasm of the Choroid Plexus 12 29
Choroid Plexus Neoplasms 42 69
Malignant Neoplasm of Choroid Plexus 12
Malignant Tumor of Choroid Plexus 12
Tumor of the Choroid Plexus 12
Cancer of Choroid Plexus 12
Choroid Plexus Neoplasm 12
Tumor of Choroid Plexus 12
Choroid Plexus Tumors 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3540 DOID:5648

Summaries for Choroid Plexus Cancer

Disease Ontology : 12 A choroid plexus cancer that has material basis in epithelial cells of the choroid plexus.

MalaCards based summary : Choroid Plexus Cancer, also known as choroid plexus carcinoma, is related to childhood choroid plexus cancer and adult choroid plexus cancer, and has symptoms including headache and vomiting. An important gene associated with Choroid Plexus Cancer is TTR (Transthyretin), and among its related pathways/superpathways is Pathways Affected in Adenoid Cystic Carcinoma. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are Increased proliferation and vision/eye

Wikipedia : 71 Choroid plexus tumors are a rare type of cancer that occur from the brain tissue called choroid plexus... more...

Related Diseases for Choroid Plexus Cancer

Diseases in the Choroid Plexus Cancer family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 childhood choroid plexus cancer 31.5 ATRX GFAP IER3IP1 KCNJ13 RAD54L SMARCB1
2 adult choroid plexus cancer 12.0
3 li-fraumeni syndrome 11.5
4 rhabdoid tumors, somatic 11.2
5 choroid plexus papilloma 11.0
6 pediculus humanus corporis infestation 10.2 GFAP TTR
7 meningeal melanoma 10.2 GFAP TTR
8 thrombophlebitis 10.2 GFAP SMARCB1
9 myxopapillary ependymoma 10.2 GFAP SMARCB1
10 trombiculiasis 10.2 GFAP SMARCB1
11 intestinal pseudo-obstruction 10.2 GFAP SMARCB1
12 dysgerminoma of ovary 10.2 GFAP SMARCB1
13 central nervous system sarcoma 10.2 GFAP SMARCB1
14 temporal lobe neoplasm 10.2 GFAP SMARCB1
15 melanotic neurilemmoma 10.2 GFAP SMARCB1
16 epimetaphyseal dysplasia cataract 10.1 GFAP TTR
17 upper respiratory tract disease 10.1 GFAP KCNJ13
18 c-p angle neurinoma 10.1 GFAP SMARCB1
19 substance-induced psychosis 10.1 GFAP IER3IP1 TTR
20 epithelioid type angiomyolipoma 10.1 GFAP IER3IP1 TTR
21 liver fibrosarcoma 10.1 GFAP TP53
22 cervical adenoid cystic carcinoma 10.1 GFAP TP53
23 bronchitis 10.1 GFAP TP53
24 bile duct clear cell adenocarcinoma 10.1 GFAP TP53
25 cervical benign neoplasm 10.1 GFAP TP53
26 clear cell meningioma 10.1 GFAP TP53
27 paternal uniparental disomy of chromosome 1 10.1 GFAP TP53
28 vulvar benign neoplasm 10.1 GFAP TP53
29 porokeratosis 10.1 GFAP TP53
30 adult brainstem gliosarcoma 10.1 GFAP TP53
31 middle ear disease 10.1 GFAP TP53
32 blood group incompatibility 10.0 GFAP TP53
33 mixed epithelial stromal tumour 10.0 GFAP TP53
34 childhood embryonal testis carcinoma 10.0 GFAP TP53
35 amyloid tumor 10.0 GFAP TP53
36 choroiditis 10.0
37 brain oligodendroglioma 10.0 GFAP TP53
38 cutaneous adenocystic carcinoma 10.0 GFAP TP53
39 arthus reaction 10.0 GFAP TP53
40 childhood central nervous system primitive neuroectodermal neoplasm 10.0 GFAP TP53
41 plasmodium ovale malaria 10.0 GFAP TP53
42 pacinian tumor 10.0 GFAP TP53
43 coronary aneurysm 10.0 TP53 TTR
44 fallopian tube benign neoplasm 10.0 GFAP TP53
45 breast squamous cell carcinoma 10.0 GFAP TP53
46 central nervous system hemangioma 10.0 GFAP TP53
47 flat ductal epithelial atypia 10.0 GFAP TP53
48 interstitial lung disease 10.0 GFAP TP53
49 early myoclonic encephalopathy 9.9 GFAP TP53
50 brain stem astrocytic neoplasm 9.9 GFAP SMARCB1 TP53

Graphical network of the top 20 diseases related to Choroid Plexus Cancer:



Diseases related to Choroid Plexus Cancer

Symptoms & Phenotypes for Choroid Plexus Cancer

UMLS symptoms related to Choroid Plexus Cancer:


headache, vomiting

GenomeRNAi Phenotypes related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

MGI Mouse Phenotypes related to Choroid Plexus Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 ATRX GFAP SMARCB1 TP53 TTR

Drugs & Therapeutics for Choroid Plexus Cancer

Drugs for Choroid Plexus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Lenograstim Approved Phase 3,Phase 1,Phase 2 135968-09-1
6
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
7
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2 85622-93-1 5394
8
Thiotepa Approved Phase 3,Phase 2,Phase 1 52-24-4 5453
9
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
11
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
12
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 4342-03-4 5351166
13
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
14
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
15
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
16
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
18
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
19
Ondansetron Approved Phase 3 99614-02-5 4595
20
Dactinomycin Approved Phase 3 50-76-0 2019 457193
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
22
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
23
Camptothecin Experimental Phase 3,Phase 2,Phase 1 7689-03-4
24
Doxil Approved June 1999 Phase 3,Phase 1 31703
25 Alkylating Agents Phase 3,Phase 2,Phase 1
26 Antimetabolites Phase 3,Phase 2
27 Antimetabolites, Antineoplastic Phase 3,Phase 2
28 Antimitotic Agents Phase 3,Phase 2,Phase 1
29 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
30 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
31 Antirheumatic Agents Phase 3,Phase 2,Phase 1
32 Dermatologic Agents Phase 3,Phase 2,Phase 1
33 Etoposide phosphate Phase 3,Phase 2,Phase 1
34 Folic Acid Antagonists Phase 3,Phase 2
35 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
36 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
37 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
38 Vitamin B Complex Phase 3,Phase 2
39 Liver Extracts Phase 3,Phase 1,Phase 2
40 Adjuvants, Immunologic Phase 3,Phase 1
41 Adjuvants, Anesthesia Phase 3
42 Analgesics Phase 3
43 Analgesics, Opioid Phase 3
44 Anesthetics Phase 3
45 Anesthetics, General Phase 3
46 Anesthetics, Intravenous Phase 3
47 Central Nervous System Depressants Phase 3
48 Narcotics Phase 3
49 pancreatic polypeptide Phase 3,Phase 1
50 Peripheral Nervous System Agents Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 87)
id Name Status NCT ID Phase
1 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
4 Treatment of Tumors of the Choroid Plexus Epithelium Active, not recruiting NCT00500890 Phase 3
5 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
6 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Active, not recruiting NCT01346267 Phase 3
7 Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors Suspended NCT01014767 Phase 3
8 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
9 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2
10 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2
11 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2
12 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2
13 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2
14 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2
15 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2
16 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2
17 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2
18 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2
19 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
20 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
21 Phase II Pediatric Study With Dabrafenib in HGG Patients Not yet recruiting NCT02684058 Phase 2
22 Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Not yet recruiting NCT03173950 Phase 2
23 Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor Withdrawn NCT00003273 Phase 2
24 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
25 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1
26 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1
27 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
28 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
29 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
30 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1
31 Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors Completed NCT00303940 Phase 1
32 ABT-751 in Treating Young Patients With Refractory Solid Tumors Completed NCT00036959 Phase 1
33 Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy Completed NCT00030108 Phase 1
34 Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors Completed NCT00020150 Phase 1
35 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1
36 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1
37 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors Completed NCT01975116 Phase 1
38 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
39 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1
40 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1
41 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia Completed NCT00053963 Phase 1
42 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1
43 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1
44 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1
45 SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors Completed NCT00015899 Phase 1
46 Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer Completed NCT00053118 Phase 1
47 VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors Completed NCT00098761 Phase 1
48 O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors Completed NCT00003765 Phase 1
49 Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1
50 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1

Search NIH Clinical Center for Choroid Plexus Cancer

Cochrane evidence based reviews: choroid plexus neoplasms

Genetic Tests for Choroid Plexus Cancer

Genetic tests related to Choroid Plexus Cancer:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma 29

Anatomical Context for Choroid Plexus Cancer

MalaCards organs/tissues related to Choroid Plexus Cancer:

39
Brain

Publications for Choroid Plexus Cancer

Variations for Choroid Plexus Cancer

ClinVar genetic disease variations for Choroid Plexus Cancer:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TP53 NM_000546.5(TP53): c.854A> T (p.Glu285Val) single nucleotide variant Pathogenic rs121912667 GRCh37 Chromosome 17, 7577084: 7577084

Cosmic variations for Choroid Plexus Cancer:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10662 TP53 central nervous system,choroid plexus,other,choroid plexus carcinoma c.743G>A p.R248Q 16
2 COSM1104 SMARCB1 central nervous system,choroid plexus,other,choroid plexus carcinoma c.233-1G>C p.? 16

Expression for Choroid Plexus Cancer

Search GEO for disease gene expression data for Choroid Plexus Cancer.

Pathways for Choroid Plexus Cancer

Pathways related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.44 ATRX TP53

GO Terms for Choroid Plexus Cancer

Biological processes related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.43 ATRX RAD54L SMARCB1
2 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.16 ATRX TP53
3 determination of adult lifespan GO:0008340 8.96 RAD54L TP53
4 DNA strand renaturation GO:0000733 8.62 RAD54L TP53

Molecular functions related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 8.62 SMARCB1 TP53

Sources for Choroid Plexus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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