MCID: CHR019
MIFTS: 50

Choroid Plexus Carcinoma malady

Cancer diseases category

Summaries for Choroid Plexus Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A choroid plexus carcinoma is a type of choroid plexus tumor. more...

MalaCards: Choroid Plexus Carcinoma, also known as choroid plexus cancer, is related to adrenocortical carcinoma and atypical teratoid rhabdoid tumor. An important gene associated with Choroid Plexus Carcinoma is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds Becaplermin and dmpq dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Choroid Plexus Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

choroid plexus carcinoma 8 42 10 60
choroid plexus cancer 8 22
malignant neoplasm of the choroid plexus 8
malignant neoplasm of choroid plexus 8
malignant tumor of choroid plexus 8
tumor of the choroid plexus 8
cancer of choroid plexus 8
choroid plexus neoplasms 60
tumor of choroid plexus 8
choroid plexus tumors 44


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Disease Ontology8 DOID:5648, DOID:3540
NCIt39 C4533, C3473
MeSH34 D016545

Related Diseases for Choroid Plexus Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Choroid Plexus Carcinoma family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5TP53
2atypical teratoid rhabdoid tumor30.4SMARCB1
3choroid plexus papilloma30.4TP53
4papilloma30.3TP53
5glioblastoma multiforme30.2TP53, ADM, PDGFRA, PDGFRB
6osteosarcoma30.2CA2, PDGFRB, PDGFRA, TP53
7astrocytoma30.2TP53, SYP, PDGFRA, PDGFRB, CA2
8rhabdomyosarcoma30.2PDGFRB, PDGFRA, SMARCB1, TP53
9choroiditis11.2
10meningitis10.3
11childhood choroid plexus cancer10.3
12adult choroid plexus cancer10.3
13bone carcinoma10.1
14li-fraumeni syndrome10.1
15acute leukemia10.1
16choroid disease10.1
17disseminated intravascular coagulation10.1
18leukemia10.1
19lymphoblastic leukemia10.1
20pediatric osteosarcoma10.1
21rhabdoid tumors, somatic10.1
22pancreatitis10.0CA2
23ganglioneuroblastoma10.0SYP
24ganglioglioma10.0SYP
25glomerulonephritis10.0CA2
26merkel cell carcinoma10.0SYP
27teratoma10.0SMARCB1
28uterine sarcoma10.0PDGFRB
29gliosarcoma10.0PDGFRB
30dermatofibrosarcoma protuberans10.0PDGFRB
31mental retardation10.0CA2
32leydig cell tumor10.0PDGFRB
33neurofibromatosis10.0PDGFRA
34juvenile myelomonocytic leukemia10.0PDGFRA
35pineoblastoma10.0SYP
36subependymal giant cell astrocytoma10.0SYP
37angiosarcoma10.0PDGFRA
38dysembryoplastic neuroepithelial tumor10.0SYP
39down syndrome10.0SMARCA4
40atherosclerosis10.0PDGFRB
41rhabdoid tumor10.0SYP, SMARCB1
42deficiency anemia10.0ADM, CA2
43pilocytic astrocytoma10.0PDGFRB, SYP
44chronic myeloproliferative disease10.0PDGFRB
45hypertension10.0ADM
46anaplastic oligodendroglioma10.0PDGFRA
47pheochromocytoma10.0ADM, SYP
48ependymoma10.0SYP, PDGFRA
49neuroblastoma10.0TP53, SYP
50malignant mesothelioma10.0PDGFRB

Graphical network of the top 20 diseases related to Choroid Plexus Carcinoma:



Diseases related to choroid plexus carcinoma

Clinical Features for Choroid Plexus Carcinoma

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Drugs & Therapeutics for Choroid Plexus Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Choroid Plexus Carcinoma

Drug clinical trials:

Search ClinicalTrials for Choroid Plexus Carcinoma

Search NIH Clinical Center for Choroid Plexus Carcinoma

Search CenterWatch for Choroid Plexus Carcinoma

Genetic Tests for Choroid Plexus Carcinoma

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22GTR
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Genetic tests related to Choroid Plexus Carcinoma:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma22

Anatomical Context for Choroid Plexus Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Choroid Plexus Carcinoma:

32
Bone, Bone marrow, Thyroid

Animal Models for Choroid Plexus Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choroid Plexus Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4PDGFRB, PDGFRA, SMARCA4, TP53
2MP:00053818.2CA2, PDGFRB, PDGFRA, SMARCA4, SMARCB1, TP53
3MP:00053678.2TP53, ADM, SMARCA4, PDGFRA, PDGFRB, CA2
4MP:00053808.1PDGFRB, PDGFRA, SMARCA4, SMARCB1, ADM, TP53
5MP:00053858.0PDGFRB, PDGFRA, SMARCA4, SMARCB1, ADM, TP53
6MP:00053767.8TP53, ADM, SMARCB1, SMARCA4, PDGFRA, PDGFRB

Publications for Choroid Plexus Carcinoma

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50PubMed
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Articles related to Choroid Plexus Carcinoma:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
A rare case of congenital choroid plexus carcinoma. (22881717)
2012
2
Choroid plexus carcinoma in an adult. (22346199)
2012
3
Choroid plexus carcinoma: Case report and review of literature. (22837788)
2012
4
Fetal tumors of the choroid plexus: is differential diagnosis between papilloma and carcinoma possible? (21800389)
2011
5
Melanotic choroid plexus carcinoma of the posterior fossa. (21779301)
2011
6
Choroid plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier. (21070306)
2010
7
Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient. (20043745)
2010
8
Oncocytic choroid plexus carcinoma: case report. (20040328)
2010
9
Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report. (19834361)
2009
10
Correction: choroid plexus carcinoma. (19415940)
2009
11
Rare intraparenchymal choroid plexus carcinoma resembling atypical teratoid/rhabdoid tumor diagnosed by immunostaining for INI1 protein. (19795969)
2009
12
Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. (18762572)
2008
13
Choroid plexus carcinoma: a new case associated with a novel TP53 germ line mutation. (18208484)
2008
14
Choroid plexus carcinoma: a rare condition and its therapeutic management. (17594955)
2007
15
Secondary glioblastoma multiforme after treatment for primary choroid plexus carcinoma in childhood. (17414567)
2007
16
Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. (17576522)
2007
17
Rhabdoid choroid plexus carcinoma: a rare histological type. (17876420)
2007
18
Choroid plexus papillary carcinoma associated with hemorrhage. A case report. (24351264)
2006
19
Choroid plexus carcinoma in a goat. (16820166)
2006
20
Mutational analysis of hSNF5/INI1 and TP53 genes in choroid plexus carcinomas. (15642401)
2005
21
Successful therapy of choroid plexus carcinoma. (15236288)
2004
22
A case report of a choroid plexus carcinoma spontaneously occurring in the right lateral ventricle of a 14-week-old, female Donryu rat. (15200166)
2004
23
Choroid plexus carcinoma presented with spinal dysfunction caused by a drop metastasis: a case report. (12814258)
2003
24
Choroid plexus carcinoma in an infant. (15190665)
2003
25
Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer. (11800650)
2002
26
Is there a requirement for adjuvant therapy for choroid plexus carcinoma that has been completely resected? (12125972)
2002
27
Detection of choroid plexus carcinoma with Tc-99m sestamibi: case report and review of the literature. (11452945)
2001
28
Usefulness of synaptophysin immunohistochemistry in an adult case of choroid plexus carcinoma. (10935220)
2000
29
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
30
Radiation therapy and survival in choroid plexus carcinoma. (10382700)
1999
31
Chemotherapy of choroid plexus carcinoma. (10550588)
1999
32
Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. (9595484)
1998
33
Spontaneous choroid plexus carcinoma in an albino rat. (9681653)
1998
34
Choroid plexus carcinoma of the lateral ventricle. (9353468)
1997
35
The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (9182293)
1996
36
Endoreduplication and telomeric association in a choroid plexus carcinoma. (8646745)
1996
37
Choroid plexus carcinoma: a report of two cases and review of the literature. (8837074)
1996
38
Choroid plexus carcinoma. (8979596)
1996
39
Primary carcinoma of the choroid plexus in Li-Fraumeni syndrome: case report. (8421542)
1993
40
Bilateral choroid plexus carcinoma of the lateral ventricles. US, CT and MR findings. (1501944)
1992
41
Primary choroid plexus carcinoma in an infant. Report of a case evaluated by MRI. (1306205)
1992
42
Choroid plexus carcinoma of childhood. (1728390)
1992
43
Choroid plexus carcinoma. Cytologic identification of malignant cells in ascitic fluid. (2450440)
1988
44
Choroid plexus carcinoma: report of a case with radiographic and ultrastructure correlation. (3710847)
1986
45
The fine structure of choroid plexus carcinoma. (6662512)
1983
46
Choroid plexus carcinoma. Report of a case with immunohistochemical and ultrastructural observations. (6821827)
1983
47
Choroid plexus carcinoma in a child: a case report. (539483)
1979
48
Choroid plexus carcinoma (a case report). (521848)
1979
49
Choroid plexus carcinoma--a case report. (1028945)
1976
50
Choroid plexus carcinoma. (1185253)
1975

Genetic Variations for Choroid Plexus Carcinoma

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Expression for genes affiliated with Choroid Plexus Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroid Plexus Carcinoma

Search GEO for disease gene expression data for Choroid Plexus Carcinoma.

Pathways for genes affiliated with Choroid Plexus Carcinoma

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12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG, 59Tocris Bioscience
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Compounds for genes affiliated with Choroid Plexus Carcinoma

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11DrugBank, 59Tocris Bioscience, 44Novoseek, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1Becaplermin1110.0PDGFRA, PDGFRB
2dmpq dihydrochloride5910.0PDGFRB, PDGFRA
3su 16f5910.0PDGFRB, PDGFRA
4su 66685910.0PDGFRB, PDGFRA
5sunitinib malate5910.0PDGFRB, PDGFRA
6pkc 4124410.0PDGFRA, PDGFRB
7ag-1296449.9PDGFRA, PDGFRB
8Pazopanib119.9PDGFRA, PDGFRB
9Regorafenib119.8PDGFRB, PDGFRA
10sunitinib44 49 1111.8PDGFRA, PDGFRB
11paraffin449.8ADM, SYP, PDGFRB
12dutp449.6SYP, ADM, TP53
13calcitriol44 59 11 2412.5PDGFRA, PDGFRB, CA2
14cyclic amp44 2410.2ADM, SMARCA4, SYP, CA2
15steroid449.1ADM, SMARCA4, SYP, CA2
16h2o2448.9PDGFRB, SYP, ADM, TP53
17cysteine448.9CA2, PDGFRB, SYP, SMARCA4, ADM
18atp44 289.9CA2, PDGFRB, PDGFRA, SMARCA4, ADM
19vegf448.8PDGFRB, PDGFRA, SYP, ADM, TP53
20progesterone44 59 28 11 2412.8PDGFRB, SYP, SMARCA4, ADM, TP53
21testosterone44 59 11 2411.7PDGFRB, SYP, SMARCA4, ADM
22lipid448.6CA2, PDGFRB, SYP, SMARCA4, ADM
23retinoic acid44 249.6CA2, PDGFRB, PDGFRA, SYP, ADM, TP53
24tyrosine448.5CA2, PDGFRB, PDGFRA, SYP, SMARCA4, ADM
25oligonucleotide448.4CA2, PDGFRB, PDGFRA, SMARCA4, ADM, TP53
26estrogen448.1TP53, CA2, PDGFRB, PDGFRA, SYP, SMARCA4

GO Terms for genes affiliated with Choroid Plexus Carcinoma

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16Gene Ontology
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Cellular components related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SWI/SNF complexGO:0165149.7SMARCB1, SMARCA4
2intrinsic to plasma membraneGO:0312269.7PDGFRA, PDGFRB
3npBAF complexGO:0715649.6SMARCB1, SMARCA4
4nBAF complexGO:0715659.4SMARCB1, SMARCA4

Biological processes related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:00183510.0SMARCB1, SMARCA4
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.0PDGFRA, PDGFRB
3metanephric glomerular capillary formationGO:07227710.0PDGFRA, PDGFRB
4positive regulation of phospholipase C activityGO:0108639.9PDGFRA, PDGFRB
5retina vasculature development in camera-type eyeGO:0612989.9PDGFRA, PDGFRB
6positive regulation by host of viral transcriptionGO:0439239.9SMARCA4, SMARCB1
7cardiac myofibril assemblyGO:0550039.9PDGFRB, PDGFRA
8nucleosome disassemblyGO:0063379.9SMARCB1, SMARCA4
9cell chemotaxisGO:0603269.8PDGFRB, PDGFRA
10adrenal gland developmentGO:0303259.8PDGFRA, PDGFRB
11platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRB, PDGFRA
12odontogenesis of dentin-containing toothGO:0424759.7CA2, PDGFRA, ADM
13positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.6PDGFRB, PDGFRA
14positive regulation of reactive oxygen species metabolic processGO:20003799.3TP53, PDGFRB
15in utero embryonic developmentGO:0017019.2TP53, PDGFRA, PDGFRB

Molecular functions related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.8PDGFRA, PDGFRB
2platelet-derived growth factor receptor bindingGO:0051619.7PDGFRA, PDGFRB
3Tat protein bindingGO:0309579.6SMARCA4, SMARCB1
4platelet-derived growth factor bindingGO:0484079.4PDGFRA, PDGFRB
5p53 bindingGO:0020399.2TP53, SMARCB1, SMARCA4

Products for genes affiliated with Choroid Plexus Carcinoma

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Sources for Choroid Plexus Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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46OMIM
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50PubMed
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57SNOMED-CT via Orphanet
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