MCID: CHR019
MIFTS: 46

Choroid Plexus Carcinoma malady

Cancer category

Summaries for Choroid Plexus Carcinoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A choroid plexus carcinoma is a type of choroid plexus tumor. more...

MalaCards: Choroid Plexus Carcinoma, also known as choroid plexus cancer, is related to adrenocortical carcinoma and atypical teratoid rhabdoid tumor. An important gene associated with Choroid Plexus Carcinoma is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds Becaplermin and dmpq dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thyroid and fetal thyroid, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Choroid Plexus Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

choroid plexus carcinoma 8 43 10 61
choroid plexus cancer 8 22
malignant neoplasm of the choroid plexus 8
malignant neoplasm of choroid plexus 8
malignant tumor of choroid plexus 8
tumor of the choroid plexus 8
cancer of choroid plexus 8
choroid plexus neoplasms 61
tumor of choroid plexus 8
choroid plexus tumors 45


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Disease Ontology8 DOID:5648, DOID:3540
NCIt40 C4533, C3473
MeSH35 D016545

Related Diseases for Choroid Plexus Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Choroid Plexus Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.6TP53
2atypical teratoid rhabdoid tumor30.5SMARCB1
3choroid plexus papilloma30.5TP53
4rhabdoid tumor30.5SYP, SMARCB1
5ependymoma30.5SYP, PDGFRA
6pilocytic astrocytoma30.2PDGFRB, SYP
7astrocytoma30.2TP53, SYP, PDGFRA, PDGFRB, CA2
8childhood choroid plexus cancer10.3
9adult choroid plexus cancer10.3
10bone carcinoma10.2
11acute leukemia10.2
12rhabdoid tumors, somatic10.2
13choroid cancer10.2
14pancreatitis10.0CA2
15ganglioneuroblastoma10.0SYP
16ganglioglioma10.0SYP
17glomerulonephritis10.0CA2
18merkel cell carcinoma10.0SYP
19teratoma10.0SMARCB1
20uterine sarcoma10.0PDGFRB
21gliosarcoma10.0PDGFRB
22dermatofibrosarcoma protuberans10.0PDGFRB
23mental retardation10.0CA2
24leydig cell tumor10.0PDGFRB
25neurofibromatosis10.0PDGFRA
26juvenile myelomonocytic leukemia10.0PDGFRA
27pineoblastoma10.0SYP
28papilloma10.0TP53
29subependymal giant cell astrocytoma10.0SYP
30angiosarcoma10.0PDGFRA
31dysembryoplastic neuroepithelial tumor10.0SYP
32down syndrome10.0SMARCA4
33atherosclerosis10.0PDGFRB
34deficiency anemia10.0ADM, CA2
35chronic myeloproliferative disease10.0PDGFRB
36hypertension10.0ADM
37anaplastic oligodendroglioma10.0PDGFRA
38pheochromocytoma10.0ADM, SYP
39neuroblastoma10.0TP53, SYP
40malignant mesothelioma10.0PDGFRB
41gastrointestinal stromal tumor10.0PDGFRA, PDGFRB
42chordoma10.0PDGFRB, PDGFRA
43lung cancer10.0TP53, SYP
44chondrosarcoma10.0PDGFRA, PDGFRB
45arteriosclerosis10.0PDGFRA, ADM
46myelofibrosis10.0PDGFRA, PDGFRB
47systemic mastocytosis10.0PDGFRA, PDGFRB
48tuberous sclerosis10.0SYP, PDGFRB
49endometrial stromal sarcoma10.0PDGFRA, PDGFRB
50teratocarcinoma10.0SYP, PDGFRA

Graphical network of the top 20 diseases related to Choroid Plexus Carcinoma:



Diseases related to choroid plexus carcinoma

Clinical Features for Choroid Plexus Carcinoma

Drugs & Therapeutics for Choroid Plexus Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Choroid Plexus Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Choroid Plexus Carcinoma

Search CenterWatch for Choroid Plexus Carcinoma

Genetic Tests for Choroid Plexus Carcinoma

Sources:
22GTR
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Genetic tests related to Choroid Plexus Carcinoma:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma22

Anatomical Context for Choroid Plexus Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Choroid Plexus Carcinoma:

33
Bone marrow, Thyroid, Fetal thyroid

Animal Models for Choroid Plexus Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Choroid Plexus Carcinoma

Sources:
51PubMed
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Articles related to Choroid Plexus Carcinoma:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Gross total resection improves overall survival in children with choroid plexus carcinoma. (24166581)
2014
2
Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. (23151741)
2013
3
Coincident choroid plexus carcinoma and adrenocortical tumor in an infant. (22752623)
2013
4
A novel TP53 somatic mutation involved in the pathogenesis of pediatric choroid plexus carcinoma. (22534715)
2012
5
Choroid plexus carcinoma in an adult. (22346199)
2012
6
Choroid plexus carcinoma: prenatal characterization by 3-dimensional sonography and magnetic resonance imaging, perinatal management, and natural history. (22298879)
2012
7
Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil. (21445348)
2011
8
A rare case of papillary carcinoma of choroids plexus: Its management and review of literature. (22174502)
2011
9
Invasive pneumococcal disease following treatment for choroid plexus carcinoma. (20076974)
2010
10
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. (20515336)
2010
11
The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. (20004534)
2010
12
Choroid plexus carcinoma: report of two cases. (19679976)
2009
13
Choroid plexus carcinoma. (18684041)
2008
14
Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas. (18157090)
2008
15
Letter to the editor. A case of inborn choroid plexus carcinoma. (24351311)
2007
16
Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report. (16723819)
2006
17
CT and MR Imaging in Choroid Plexus Carcinoma. Report of Two Cases. (24351218)
2006
18
Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1. (16784985)
2006
19
Choroid plexus carcinoma in a goat. (16820166)
2006
20
Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice. (16552004)
2006
21
Choroid plexus carcinoma in the adult: is there a role for chemotherapy? (16270538)
2005
22
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. (15892296)
2005
23
Shunt-related abdominal metastases in a child with choroid plexus carcinoma: case report. (15670391)
2005
24
Choroid plexus carcinoma. (12116091)
2002
25
Magnetic resonance imaging in the diagnosis and management of choroid plexus carcinoma in children. (11512001)
2001
26
Choroid plexus carcinoma in an adult. (11531769)
2001
27
Primary choroid plexus carcinoma producing carbohydrate antigen 19-9. (11128618)
2000
28
Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. (10874668)
2000
29
Magnetic resonance imaging of a choroid plexus carcinoma and meningeal carcinomatosis in a dog. (10519302)
1999
30
Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. (9595484)
1998
31
Choroid plexus carcinoma in an infant. (9170025)
1997
32
Pigmented choroid plexus carcinoma: a cytogenetic and ultrastructural study. (9209468)
1997
33
Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems. (8878450)
1996
34
Intraoperative radiation therapy and chemotherapy for huge choroid plexus carcinoma in an infant--case report. (8869156)
1996
35
Choroid plexus carcinoma. Case report. (8855084)
1996
36
The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. (7737660)
1995
37
Choroid plexus carcinoma of the lateral ventricle. Report of a case in an adult. (8187382)
1994
38
Bilateral choroid plexus carcinoma of the lateral ventricles. US, CT and MR findings. (1501944)
1992
39
Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children. (1541980)
1992
40
Current management of choroid plexus carcinoma in children. (1822687)
1991-1992
41
Choroid plexus carcinoma--report of a case with metastases within the central nervous system. (2185805)
1990
42
Antigenic expression in human choroid plexus carcinoma: report of 2 cases]. (2264788)
1990
43
Choroid plexus carcinoma in a dog. (2723160)
1989
44
Choroid plexus carcinoma in siblings: a study by light and electron microscopy with Ki-67 immunocytochemistry. (2732756)
1989
45
Choroid plexus carcinoma. Report of a case with positron emission tomographic study. (3489905)
1986
46
Third ventricle choroid plexus carcinoma. (6518429)
1984
47
Choroid plexus carcinoma with meningeal carcinomatosis in a dog. (7368530)
1980
48
Choroid plexus carcinoma in a child: a case report. (539483)
1979
49
Choroid plexus carcinoma (a case report). (521848)
1979
50
Choroid plexus carcinoma. Case report. (532467)
1979

Genetic Variations for Choroid Plexus Carcinoma

Expression for genes affiliated with Choroid Plexus Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroid Plexus Carcinoma

Search GEO for disease gene expression data for Choroid Plexus Carcinoma.

Pathways for genes affiliated with Choroid Plexus Carcinoma

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 30KEGG, 60Tocris Bioscience
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Compounds for genes affiliated with Choroid Plexus Carcinoma

Sources:
11DrugBank, 60Tocris Bioscience, 45Novoseek, 50PharmGKB, 24HMDB, 29IUPHAR
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Compounds related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1Becaplermin1110.0PDGFRA, PDGFRB
2dmpq dihydrochloride6010.0PDGFRB, PDGFRA
3su 16f6010.0PDGFRB, PDGFRA
4su 66686010.0PDGFRB, PDGFRA
5sunitinib malate6010.0PDGFRB, PDGFRA
6pkc 4124510.0PDGFRA, PDGFRB
7ag-1296459.9PDGFRA, PDGFRB
8Pazopanib119.9PDGFRA, PDGFRB
9Regorafenib119.8PDGFRB, PDGFRA
10sunitinib45 50 1111.8PDGFRA, PDGFRB
11paraffin459.8ADM, SYP, PDGFRB
12dutp459.6SYP, ADM, TP53
13calcitriol45 60 11 2412.5PDGFRA, PDGFRB, CA2
14cyclic amp45 2410.2ADM, SMARCA4, SYP, CA2
15steroid459.1ADM, SMARCA4, SYP, CA2
16h2o2458.9PDGFRB, SYP, ADM, TP53
17cysteine458.9CA2, PDGFRB, SYP, SMARCA4, ADM
18atp45 299.9CA2, PDGFRB, PDGFRA, SMARCA4, ADM
19vegf458.8PDGFRB, PDGFRA, SYP, ADM, TP53
20progesterone45 60 29 11 2412.8PDGFRB, SYP, SMARCA4, ADM, TP53
21testosterone45 60 11 2411.7PDGFRB, SYP, SMARCA4, ADM
22lipid458.6CA2, PDGFRB, SYP, SMARCA4, ADM
23retinoic acid45 249.6CA2, PDGFRB, PDGFRA, SYP, ADM, TP53
24tyrosine458.5CA2, PDGFRB, PDGFRA, SYP, SMARCA4, ADM
25oligonucleotide458.4CA2, PDGFRB, PDGFRA, SMARCA4, ADM, TP53
26estrogen458.1TP53, CA2, PDGFRB, PDGFRA, SYP, SMARCA4

GO Terms for genes affiliated with Choroid Plexus Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SWI/SNF complexGO:0165149.7SMARCB1, SMARCA4
2intrinsic to plasma membraneGO:0312269.7PDGFRA, PDGFRB
3npBAF complexGO:0715649.6SMARCB1, SMARCA4
4nBAF complexGO:0715659.4SMARCB1, SMARCA4

Biological processes related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:00183510.0SMARCB1, SMARCA4
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.0PDGFRA, PDGFRB
3metanephric glomerular capillary formationGO:07227710.0PDGFRA, PDGFRB
4positive regulation of phospholipase C activityGO:0108639.9PDGFRA, PDGFRB
5retina vasculature development in camera-type eyeGO:0612989.9PDGFRA, PDGFRB
6positive regulation by host of viral transcriptionGO:0439239.9SMARCA4, SMARCB1
7cardiac myofibril assemblyGO:0550039.9PDGFRB, PDGFRA
8nucleosome disassemblyGO:0063379.9SMARCB1, SMARCA4
9cell chemotaxisGO:0603269.8PDGFRB, PDGFRA
10adrenal gland developmentGO:0303259.8PDGFRA, PDGFRB
11platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRB, PDGFRA
12odontogenesis of dentin-containing toothGO:0424759.7CA2, PDGFRA, ADM
13positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.6PDGFRB, PDGFRA
14positive regulation of reactive oxygen species metabolic processGO:20003799.3TP53, PDGFRB
15in utero embryonic developmentGO:0017019.2TP53, PDGFRA, PDGFRB

Molecular functions related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.8PDGFRA, PDGFRB
2platelet-derived growth factor receptor bindingGO:0051619.7PDGFRA, PDGFRB
3Tat protein bindingGO:0309579.6SMARCA4, SMARCB1
4platelet-derived growth factor bindingGO:0484079.4PDGFRA, PDGFRB
5p53 bindingGO:0020399.2TP53, SMARCB1, SMARCA4

Products for genes affiliated with Choroid Plexus Carcinoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Choroid Plexus Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet