MCID: CHR019
MIFTS: 53

Choroid Plexus Carcinoma malady

Rare diseases, Cancer diseases categories

Summaries for Choroid Plexus Carcinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A choroid plexus carcinoma is a type of choroid plexus tumor. more...

MalaCards: Choroid Plexus Carcinoma, also known as choroid plexus cancer, is related to choroid plexus papilloma and rhabdoid tumor. An important gene associated with Choroid Plexus Carcinoma is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Transcription Ligand dependent activation of the ESR1 SP pathway and Regulation of retinoblastoma protein. The compounds dmpq dihydrochloride and su 16f have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Choroid Plexus Carcinoma

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9Disease Ontology, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

choroid plexus carcinoma 9 44 11 63
choroid plexus cancer 9 23
malignant neoplasm of the choroid plexus 9
malignant neoplasm of choroid plexus 9
malignant tumor of choroid plexus 9
tumor of the choroid plexus 9
cancer of choroid plexus 9
choroid plexus neoplasms 63
tumor of choroid plexus 9
choroid plexus tumors 46


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Disease Ontology9 DOID:5648, DOID:3540
NCIt41 C4533, C3473
MeSH36 D016545

Related Diseases for Choroid Plexus Carcinoma

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18GeneCards, 19GeneDecks
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Diseases in the Choroid Plexus Carcinoma family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma30.6TP53
2rhabdoid tumor30.6SYP, SMARCB1
3ependymoma30.5SYP, PDGFRA
4adrenocortical carcinoma30.5TP53, SYP, ADM
5pilocytic astrocytoma30.3PDGFRB, SYP
6rhabdomyosarcoma30.2SMARCB1, PDGFRB, TP53, PDGFRA
7osteosarcoma30.2PDGFRB, CA2, PDGFRA, TP53
8glioblastoma multiforme30.1TP53, PDGFRA, ADM, SMARCB1, PDGFRB
9astrocytoma30.1SYP, TP53, PDGFRA, PDGFRB, CA2
10leukemia30.1SMARCA4, TP53, PDGFRA, PDGFRB
11choroiditis11.2
12atypical teratoid rhabdoid tumor10.3
13meningitis10.3
14adult choroid plexus cancer10.3
15childhood choroid plexus cancer10.3
16papilloma10.3
17li-fraumeni syndrome10.2
18disseminated intravascular coagulation10.2
19lymphoblastic leukemia10.2
20rhabdoid tumors, somatic10.2
21endolymphatic sac tumor10.2
22dysembryoplastic neuroepithelial tumor10.1SYP
23pineoblastoma10.1SYP
24subependymal giant cell astrocytoma10.1SYP
25gliosarcoma10.1PDGFRB
26adrenal adenoma10.0SYP, ADM
27prion disease10.0SYP
28arteriosclerosis10.0ADM, PDGFRA
29chondrosarcoma10.0PDGFRB, PDGFRA
30desmoid tumor10.0PDGFRB, PDGFRA
31systemic mastocytosis10.0PDGFRA, PDGFRB
32endometrial stromal sarcoma10.0PDGFRA, PDGFRB
33hypereosinophilic syndrome10.0PDGFRB, PDGFRA
34chronic myelomonocytic leukemia10.0PDGFRA, PDGFRB
35chordoma10.0PDGFRA, PDGFRB
36mastocytosis10.0PDGFRA, PDGFRB
37myelofibrosis10.0PDGFRB, PDGFRA
38meningioma10.0SMARCB1, PDGFRB, SYP
39polycythemia vera10.0PDGFRB, PDGFRA
40gastrointestinal stromal tumor10.0PDGFRB, PDGFRA
41neurilemmoma10.0SMARCB1, PDGFRA, PDGFRB
42pancreatic cancer10.0SYP, CA2, PDGFRB
43brain cancer10.0SYP, PDGFRB, TP53
44neurofibroma10.0PDGFRB, SYP, PDGFRA
45tuberous sclerosis10.0PDGFRB, SYP
46esophageal cancer10.0TP53, PDGFRB
47lung small cell carcinoma10.0SYP, PDGFRA, TP53
48systemic scleroderma10.0PDGFRB, PDGFRA, CA2
49lung benign neoplasm10.0SMARCA4, TP53, SYP
50leiomyosarcoma9.9SMARCB1, PDGFRB, PDGFRA, TP53

Graphical network of the top 20 diseases related to Choroid Plexus Carcinoma:



Diseases related to choroid plexus carcinoma

Symptoms for Choroid Plexus Carcinoma

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Drugs & Therapeutics for Choroid Plexus Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Choroid Plexus Carcinoma

Search CenterWatch for Choroid Plexus Carcinoma

Genetic Tests for Choroid Plexus Carcinoma

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23GTR
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Genetic tests related to Choroid Plexus Carcinoma:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma23

Anatomical Context for Choroid Plexus Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Choroid Plexus Carcinoma:

34
Bone marrow, Bone

Animal Models for Choroid Plexus Carcinoma or affiliated genes

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38MGI
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Publications for Choroid Plexus Carcinoma

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53PubMed
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Articles related to Choroid Plexus Carcinoma:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Gross total resection improves overall survival in children with choroid plexus carcinoma. (24166581)
2014
2
Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant. (23427033)
2013
3
Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. (23151741)
2013
4
Coincident choroid plexus carcinoma and adrenocortical tumor in an infant. (22752623)
2013
5
The cytologic findings in choroid plexus carcinoma: report of a case with differential diagnosis. (22180231)
2012
6
A rare case of congenital choroid plexus carcinoma. (22881717)
2012
7
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. (21442238)
2011
8
Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil. (21445348)
2011
9
Melanotic choroid plexus carcinoma of the posterior fossa. (21779301)
2011
10
Invasive pneumococcal disease following treatment for choroid plexus carcinoma. (20076974)
2010
11
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. (20515336)
2010
12
Choroid plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier. (21070306)
2010
13
Choroid plexus carcinoma: report of two cases. (19679976)
2009
14
Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report. (19834361)
2009
15
Choroid plexus carcinoma. (18684041)
2008
16
Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. (18762572)
2008
17
Choroid plexus carcinoma: a rare condition and its therapeutic management. (17594955)
2007
18
Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report. (16723819)
2006
19
Images in neuro-oncology: choroid plexus carcinoma. (16794748)
2006
20
Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations. (15925506)
2005
21
Choroid plexus carcinoma in the adult: is there a role for chemotherapy? (16270538)
2005
22
Successful treatment of an unresectable choroid plexus carcinoma in a patient with Li-Fraumeni syndrome. (15654279)
2005
23
Successful therapy of choroid plexus carcinoma. (15236288)
2004
24
Choroid plexus carcinoma presented with spinal dysfunction caused by a drop metastasis: a case report. (12814258)
2003
25
Efficacy of sequential chemotherapy including methotrexate and doxorubicin in an infant with partially resected choroid plexus carcinoma. (12476023)
2003
26
Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer. (11800650)
2002
27
Primary choroid plexus carcinoma producing carbohydrate antigen 19-9. (11128618)
2000
28
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
29
Magnetic resonance imaging of a choroid plexus carcinoma and meningeal carcinomatosis in a dog. (10519302)
1999
30
Radiation therapy and survival in choroid plexus carcinoma. (10382700)
1999
31
Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. (9595484)
1998
32
Choroid plexus carcinoma in an infant. (9170025)
1997
33
Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems. (8878450)
1996
34
Endoreduplication and telomeric association in a choroid plexus carcinoma. (8646745)
1996
35
The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. (7737660)
1995
36
Choroid plexus carcinoma in the lateral ventricle--case report. (8532130)
1995
37
Choroid plexus carcinoma of the lateral ventricle. Report of a case in an adult. (8187382)
1994
38
Magnetic resonance imaging in a dog with choroid plexus carcinoma. (8286551)
1993
39
Bilateral choroid plexus carcinoma of the lateral ventricles. US, CT and MR findings. (1501944)
1992
40
Primary choroid plexus carcinoma in an infant. Report of a case evaluated by MRI. (1306205)
1992
41
Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children. (1541980)
1992
42
Current management of choroid plexus carcinoma in children. (1822687)
1991-1992
43
Choroid plexus carcinoma in siblings. (2307984)
1990
44
Choroid plexus carcinoma in a dog. (2723160)
1989
45
Choroid plexus carcinoma of the fourth ventricle. Report of a case in an infant. (3075286)
1988
46
Choroid plexus carcinoma: report of a case with radiographic and ultrastructure correlation. (3710847)
1986
47
The fine structure of choroid plexus carcinoma. (6662512)
1983
48
Choroid plexus carcinoma. Report of a case with immunohistochemical and ultrastructural observations. (6821827)
1983
49
Choroid plexus carcinoma in a child: a case report. (539483)
1979
50
Choroid plexus carcinoma--a case report. (1028945)
1976

Variations for Choroid Plexus Carcinoma

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Expression for genes affiliated with Choroid Plexus Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroid Plexus Carcinoma

Search GEO for disease gene expression data for Choroid Plexus Carcinoma.

Pathways for genes affiliated with Choroid Plexus Carcinoma

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 13EMD Millipore, 31KEGG, 55R&D Systems, 62Tocris Bioscience
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Pathways related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway61
9.7SMARCA4, SMARCB1
29.7SMARCA4, SMARCB1
39.6PDGFRA, PDGFRB
49.6PDGFRB, PDGFRA
5
Show member pathways
PDGF Pathway39
9.6PDGFRB, PDGFRA
69.4PDGFRA, TP53
7
Show member pathways
9.0SMARCB1, SMARCA4, TP53
89.0TP53, PDGFRA, PDGFRB
99.0PDGFRB, PDGFRA, TP53
109.0PDGFRB, PDGFRA, TP53
119.0PDGFRB, PDGFRA, TP53
129.0TP53, PDGFRA, PDGFRB
13
Show member pathways
MAPK signaling pathway39
9.0TP53, PDGFRA, PDGFRB
14
Show member pathways
Signaling Pathways in Glioblastoma39
9.0PDGFRB, PDGFRA, TP53
15
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.0TP53, PDGFRA, PDGFRB
16
Show member pathways
9.0TP53, PDGFRA, PDGFRB
179.0PDGFRB, PDGFRA, TP53
18
Show member pathways
9.0TP53, PDGFRA, PDGFRB
19
Show member pathways
8.2PDGFRB, PDGFRA, TP53, SMARCA4, SMARCB1

Compounds for genes affiliated with Choroid Plexus Carcinoma

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62Tocris Bioscience, 46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1dmpq dihydrochloride6210.0PDGFRA, PDGFRB
2su 16f6210.0PDGFRA, PDGFRB
3su 66686210.0PDGFRA, PDGFRB
4sunitinib malate6210.0PDGFRA, PDGFRB
5pkc 4124610.0PDGFRA, PDGFRB
6ag-1296469.9PDGFRB, PDGFRA
7pazopanib52 1210.9PDGFRB, PDGFRA
8sunitinib46 52 1211.9PDGFRB, PDGFRA
9regorafenib52 1210.9PDGFRB, PDGFRA
10streptozotocin469.7SYP, ADM
11ang ii469.7ADM, PDGFRB
12norepinephrine46 25 1211.6CA2, SYP, ADM
13dutp469.6TP53, ADM, SYP
14topotecan46 1210.5TP53, PDGFRB
15calcitriol46 62 25 1212.5PDGFRB, PDGFRA, CA2
16depsipeptide469.5PDGFRB, TP53
17phosphotyrosine469.5PDGFRB, PDGFRA, SYP
18histidine469.4SMARCA4, SYP, CA2
19flavopiridol46 1210.4PDGFRB, TP53
20cyclic amp46 2510.3CA2, SYP, ADM, SMARCA4
21actinomycin d469.2CA2, ADM, TP53
22steroid469.2SMARCA4, ADM, SYP, CA2
23testosterone46 62 25 1212.1SMARCA4, ADM, SYP, PDGFRB
24h2o2469.1TP53, ADM, SYP, PDGFRB
25arginine468.9SMARCA4, TP53, ADM, CA2
26cysteine468.8PDGFRB, CA2, SYP, ADM, SMARCA4
27lipid468.8SMARCA4, ADM, SYP, CA2, PDGFRB
28atp46 309.8SMARCA4, ADM, CA2, PDGFRA, PDGFRB
29paraffin468.7TP53, ADM, SYP, PDGFRA, PDGFRB
30proline468.7PDGFRB, CA2, TP53
31vegf468.7PDGFRB, PDGFRA, SYP, ADM, TP53
32progesterone46 30 62 25 1212.6PDGFRB, SYP, ADM, TP53, SMARCA4
33tyrosine468.4SMARCA4, ADM, SYP, CA2, PDGFRA, PDGFRB
34retinoic acid46 259.4TP53, ADM, SYP, CA2, PDGFRA, PDGFRB
35oligonucleotide468.2SMARCA4, TP53, ADM, CA2, PDGFRA, PDGFRB
36estrogen467.8PDGFRB, SMARCA4, TP53, ADM, SYP, CA2

GO Terms for genes affiliated with Choroid Plexus Carcinoma

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17Gene Ontology
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Cellular components related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1npBAF complexGO:0715649.7SMARCA4, SMARCB1
2SWI/SNF complexGO:0165149.7SMARCA4, SMARCB1
3nBAF complexGO:0715659.6SMARCA4, SMARCB1
4intrinsic component of plasma membraneGO:0312269.3PDGFRB, PDGFRA

Biological processes related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:0018359.9SMARCA4, SMARCB1
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:0380919.9PDGFRB, PDGFRA
3metanephric glomerular capillary formationGO:0722779.9PDGFRB, PDGFRA
4positive regulation by host of viral transcriptionGO:0439239.9SMARCA4, SMARCB1
5retina vasculature development in camera-type eyeGO:0612989.9PDGFRA, PDGFRB
6positive regulation of phospholipase C activityGO:0108639.9PDGFRA, PDGFRB
7nucleosome disassemblyGO:0063379.9SMARCA4, SMARCB1
8cardiac myofibril assemblyGO:0550039.9PDGFRB, PDGFRA
9adrenal gland developmentGO:0303259.8PDGFRA, PDGFRB
10positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRB, PDGFRA
11platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRA, PDGFRB
12odontogenesis of dentin-containing toothGO:0424759.7ADM, CA2, PDGFRA
13vasculogenesisGO:0015709.6ADM, SMARCA4
14cell chemotaxisGO:0603269.6PDGFRB, PDGFRA
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5PDGFRA, PDGFRB
16positive regulation of reactive oxygen species metabolic processGO:20003799.5TP53, PDGFRB
17in utero embryonic developmentGO:0017019.2PDGFRB, PDGFRA, TP53
18negative regulation of cell proliferationGO:0082858.9ADM, TP53, SMARCB1

Molecular functions related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.7PDGFRA, PDGFRB
2Tat protein bindingGO:0309579.7SMARCB1, SMARCA4
3platelet-derived growth factor bindingGO:0484079.5PDGFRB, PDGFRA
4platelet-derived growth factor receptor bindingGO:0051619.3PDGFRA, PDGFRB
5p53 bindingGO:0020399.1TP53, SMARCA4, SMARCB1
6protein bindingGO:0055157.5ADM, SMARCA4, SMARCB1, CA2, PDGFRA, PDGFRB

Products for genes affiliated with Choroid Plexus Carcinoma

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Sources for Choroid Plexus Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet