MCID: CHR019
MIFTS: 50

Choroid Plexus Carcinoma malady

Cancer diseases category

Summaries for Choroid Plexus Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A choroid plexus carcinoma is a type of choroid plexus tumor. more...

MalaCards: Choroid Plexus Carcinoma, also known as choroid plexus cancer, is related to adrenocortical carcinoma and atypical teratoid rhabdoid tumor. An important gene associated with Choroid Plexus Carcinoma is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds Becaplermin and dmpq dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and thyroid, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Choroid Plexus Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

choroid plexus carcinoma 8 42 10 60
choroid plexus cancer 8 22
malignant neoplasm of the choroid plexus 8
malignant neoplasm of choroid plexus 8
malignant tumor of choroid plexus 8
tumor of the choroid plexus 8
cancer of choroid plexus 8
choroid plexus neoplasms 60
tumor of choroid plexus 8
choroid plexus tumors 44


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Disease Ontology8 DOID:5648, DOID:3540
NCIt39 C4533, C3473
MeSH34 D016545

Related Diseases for Choroid Plexus Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Choroid Plexus Carcinoma family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5TP53
2atypical teratoid rhabdoid tumor30.4SMARCB1
3choroid plexus papilloma30.4TP53
4papilloma30.3TP53
5glioblastoma multiforme30.2TP53, ADM, PDGFRA, PDGFRB
6osteosarcoma30.2CA2, PDGFRB, PDGFRA, TP53
7astrocytoma30.2TP53, SYP, PDGFRA, PDGFRB, CA2
8rhabdomyosarcoma30.2PDGFRB, PDGFRA, SMARCB1, TP53
9choroiditis11.2
10meningitis10.3
11childhood choroid plexus cancer10.3
12adult choroid plexus cancer10.3
13bone carcinoma10.1
14li-fraumeni syndrome10.1
15acute leukemia10.1
16choroid disease10.1
17disseminated intravascular coagulation10.1
18leukemia10.1
19lymphoblastic leukemia10.1
20pediatric osteosarcoma10.1
21rhabdoid tumors, somatic10.1
22pancreatitis10.0CA2
23ganglioneuroblastoma10.0SYP
24ganglioglioma10.0SYP
25glomerulonephritis10.0CA2
26merkel cell carcinoma10.0SYP
27teratoma10.0SMARCB1
28uterine sarcoma10.0PDGFRB
29gliosarcoma10.0PDGFRB
30dermatofibrosarcoma protuberans10.0PDGFRB
31mental retardation10.0CA2
32leydig cell tumor10.0PDGFRB
33neurofibromatosis10.0PDGFRA
34juvenile myelomonocytic leukemia10.0PDGFRA
35pineoblastoma10.0SYP
36subependymal giant cell astrocytoma10.0SYP
37angiosarcoma10.0PDGFRA
38dysembryoplastic neuroepithelial tumor10.0SYP
39down syndrome10.0SMARCA4
40atherosclerosis10.0PDGFRB
41rhabdoid tumor10.0SYP, SMARCB1
42deficiency anemia10.0ADM, CA2
43pilocytic astrocytoma10.0PDGFRB, SYP
44chronic myeloproliferative disease10.0PDGFRB
45hypertension10.0ADM
46anaplastic oligodendroglioma10.0PDGFRA
47pheochromocytoma10.0ADM, SYP
48ependymoma10.0SYP, PDGFRA
49neuroblastoma10.0TP53, SYP
50malignant mesothelioma10.0PDGFRB

Graphical network of the top 20 diseases related to Choroid Plexus Carcinoma:



Diseases related to choroid plexus carcinoma

Clinical Features for Choroid Plexus Carcinoma

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Drugs & Therapeutics for Choroid Plexus Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Choroid Plexus Carcinoma

Drug clinical trials:

Search ClinicalTrials for Choroid Plexus Carcinoma

Search NIH Clinical Center for Choroid Plexus Carcinoma

Search CenterWatch for Choroid Plexus Carcinoma

Genetic Tests for Choroid Plexus Carcinoma

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22GTR
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Genetic tests related to Choroid Plexus Carcinoma:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma22

Anatomical Context for Choroid Plexus Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Choroid Plexus Carcinoma:

32
Bone, Bone marrow, Thyroid

Animal Models for Choroid Plexus Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choroid Plexus Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4PDGFRB, PDGFRA, SMARCA4, TP53
2MP:00053818.2CA2, PDGFRB, PDGFRA, SMARCA4, SMARCB1, TP53
3MP:00053678.2TP53, ADM, SMARCA4, PDGFRA, PDGFRB, CA2
4MP:00053808.1PDGFRB, PDGFRA, SMARCA4, SMARCB1, ADM, TP53
5MP:00053858.0PDGFRB, PDGFRA, SMARCA4, SMARCB1, ADM, TP53
6MP:00053767.8TP53, ADM, SMARCB1, SMARCA4, PDGFRA, PDGFRB

Publications for Choroid Plexus Carcinoma

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50PubMed
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Articles related to Choroid Plexus Carcinoma:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Gross total resection improves overall survival in children with choroid plexus carcinoma. (24166581)
2014
2
Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. (23151741)
2013
3
Coincident choroid plexus carcinoma and adrenocortical tumor in an infant. (22752623)
2013
4
A novel TP53 somatic mutation involved in the pathogenesis of pediatric choroid plexus carcinoma. (22534715)
2012
5
Choroid plexus carcinoma in an adult. (22346199)
2012
6
Choroid plexus carcinoma: prenatal characterization by 3-dimensional sonography and magnetic resonance imaging, perinatal management, and natural history. (22298879)
2012
7
Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil. (21445348)
2011
8
A rare case of papillary carcinoma of choroids plexus: Its management and review of literature. (22174502)
2011
9
Invasive pneumococcal disease following treatment for choroid plexus carcinoma. (20076974)
2010
10
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. (20515336)
2010
11
The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. (20004534)
2010
12
Choroid plexus carcinoma: report of two cases. (19679976)
2009
13
Choroid plexus carcinoma. (18684041)
2008
14
Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas. (18157090)
2008
15
Letter to the editor. A case of inborn choroid plexus carcinoma. (24351311)
2007
16
Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report. (16723819)
2006
17
CT and MR Imaging in Choroid Plexus Carcinoma. Report of Two Cases. (24351218)
2006
18
Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1. (16784985)
2006
19
Choroid plexus carcinoma in a goat. (16820166)
2006
20
Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice. (16552004)
2006
21
Choroid plexus carcinoma in the adult: is there a role for chemotherapy? (16270538)
2005
22
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. (15892296)
2005
23
Shunt-related abdominal metastases in a child with choroid plexus carcinoma: case report. (15670391)
2005
24
Choroid plexus carcinoma. (12116091)
2002
25
Magnetic resonance imaging in the diagnosis and management of choroid plexus carcinoma in children. (11512001)
2001
26
Choroid plexus carcinoma in an adult. (11531769)
2001
27
Primary choroid plexus carcinoma producing carbohydrate antigen 19-9. (11128618)
2000
28
Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. (10874668)
2000
29
Magnetic resonance imaging of a choroid plexus carcinoma and meningeal carcinomatosis in a dog. (10519302)
1999
30
Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. (9595484)
1998
31
Choroid plexus carcinoma in an infant. (9170025)
1997
32
Pigmented choroid plexus carcinoma: a cytogenetic and ultrastructural study. (9209468)
1997
33
Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems. (8878450)
1996
34
Intraoperative radiation therapy and chemotherapy for huge choroid plexus carcinoma in an infant--case report. (8869156)
1996
35
Choroid plexus carcinoma. Case report. (8855084)
1996
36
The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. (7737660)
1995
37
Choroid plexus carcinoma of the lateral ventricle. Report of a case in an adult. (8187382)
1994
38
Bilateral choroid plexus carcinoma of the lateral ventricles. US, CT and MR findings. (1501944)
1992
39
Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children. (1541980)
1992
40
Current management of choroid plexus carcinoma in children. (1822687)
1991-1992
41
Choroid plexus carcinoma--report of a case with metastases within the central nervous system. (2185805)
1990
42
Antigenic expression in human choroid plexus carcinoma: report of 2 cases]. (2264788)
1990
43
Choroid plexus carcinoma in a dog. (2723160)
1989
44
Choroid plexus carcinoma in siblings: a study by light and electron microscopy with Ki-67 immunocytochemistry. (2732756)
1989
45
Choroid plexus carcinoma. Report of a case with positron emission tomographic study. (3489905)
1986
46
Third ventricle choroid plexus carcinoma. (6518429)
1984
47
Choroid plexus carcinoma with meningeal carcinomatosis in a dog. (7368530)
1980
48
Choroid plexus carcinoma in a child: a case report. (539483)
1979
49
Choroid plexus carcinoma (a case report). (521848)
1979
50
Choroid plexus carcinoma. Case report. (532467)
1979

Genetic Variations for Choroid Plexus Carcinoma

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Expression for genes affiliated with Choroid Plexus Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroid Plexus Carcinoma

Search GEO for disease gene expression data for Choroid Plexus Carcinoma.

Pathways for genes affiliated with Choroid Plexus Carcinoma

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12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG, 59Tocris Bioscience
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Compounds for genes affiliated with Choroid Plexus Carcinoma

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11DrugBank, 59Tocris Bioscience, 44Novoseek, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1Becaplermin1110.0PDGFRA, PDGFRB
2dmpq dihydrochloride5910.0PDGFRB, PDGFRA
3su 16f5910.0PDGFRB, PDGFRA
4su 66685910.0PDGFRB, PDGFRA
5sunitinib malate5910.0PDGFRB, PDGFRA
6pkc 4124410.0PDGFRA, PDGFRB
7ag-1296449.9PDGFRA, PDGFRB
8Pazopanib119.9PDGFRA, PDGFRB
9Regorafenib119.8PDGFRB, PDGFRA
10sunitinib44 49 1111.8PDGFRA, PDGFRB
11paraffin449.8ADM, SYP, PDGFRB
12dutp449.6SYP, ADM, TP53
13calcitriol44 59 11 2412.5PDGFRA, PDGFRB, CA2
14cyclic amp44 2410.2ADM, SMARCA4, SYP, CA2
15steroid449.1ADM, SMARCA4, SYP, CA2
16h2o2448.9PDGFRB, SYP, ADM, TP53
17cysteine448.9CA2, PDGFRB, SYP, SMARCA4, ADM
18atp44 289.9CA2, PDGFRB, PDGFRA, SMARCA4, ADM
19vegf448.8PDGFRB, PDGFRA, SYP, ADM, TP53
20progesterone44 59 28 11 2412.8PDGFRB, SYP, SMARCA4, ADM, TP53
21testosterone44 59 11 2411.7PDGFRB, SYP, SMARCA4, ADM
22lipid448.6CA2, PDGFRB, SYP, SMARCA4, ADM
23retinoic acid44 249.6CA2, PDGFRB, PDGFRA, SYP, ADM, TP53
24tyrosine448.5CA2, PDGFRB, PDGFRA, SYP, SMARCA4, ADM
25oligonucleotide448.4CA2, PDGFRB, PDGFRA, SMARCA4, ADM, TP53
26estrogen448.1TP53, CA2, PDGFRB, PDGFRA, SYP, SMARCA4

GO Terms for genes affiliated with Choroid Plexus Carcinoma

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16Gene Ontology
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Cellular components related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SWI/SNF complexGO:0165149.7SMARCB1, SMARCA4
2intrinsic to plasma membraneGO:0312269.7PDGFRA, PDGFRB
3npBAF complexGO:0715649.6SMARCB1, SMARCA4
4nBAF complexGO:0715659.4SMARCB1, SMARCA4

Biological processes related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:00183510.0SMARCB1, SMARCA4
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.0PDGFRA, PDGFRB
3metanephric glomerular capillary formationGO:07227710.0PDGFRA, PDGFRB
4positive regulation of phospholipase C activityGO:0108639.9PDGFRA, PDGFRB
5retina vasculature development in camera-type eyeGO:0612989.9PDGFRA, PDGFRB
6positive regulation by host of viral transcriptionGO:0439239.9SMARCA4, SMARCB1
7cardiac myofibril assemblyGO:0550039.9PDGFRB, PDGFRA
8nucleosome disassemblyGO:0063379.9SMARCB1, SMARCA4
9cell chemotaxisGO:0603269.8PDGFRB, PDGFRA
10adrenal gland developmentGO:0303259.8PDGFRA, PDGFRB
11platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRB, PDGFRA
12odontogenesis of dentin-containing toothGO:0424759.7CA2, PDGFRA, ADM
13positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.6PDGFRB, PDGFRA
14positive regulation of reactive oxygen species metabolic processGO:20003799.3TP53, PDGFRB
15in utero embryonic developmentGO:0017019.2TP53, PDGFRA, PDGFRB

Molecular functions related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.8PDGFRA, PDGFRB
2platelet-derived growth factor receptor bindingGO:0051619.7PDGFRA, PDGFRB
3Tat protein bindingGO:0309579.6SMARCA4, SMARCB1
4platelet-derived growth factor bindingGO:0484079.4PDGFRA, PDGFRB
5p53 bindingGO:0020399.2TP53, SMARCB1, SMARCA4

Products for genes affiliated with Choroid Plexus Carcinoma

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Sources for Choroid Plexus Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet