MCID: CHR019
MIFTS: 55

Choroid Plexus Carcinoma malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Choroid Plexus Carcinoma

About this section


Fully expand this MalaCard
Wikipedia:65 A choroid plexus carcinoma is a type of choroid plexus tumor. more...

MalaCards based summary: Choroid Plexus Carcinoma, also known as malignant neoplasm of the choroid plexus, is related to choroid plexus papilloma and rhabdoid tumor. An important gene associated with Choroid Plexus Carcinoma is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Transcription Ligand dependent activation of the ESR1 SP pathway and Regulation of retinoblastoma protein. The compounds dmpq dihydrochloride and su 16f have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are liver/biliary system and muscle.

Disease Ontology:8 A choroid plexus cancer that has material basis in epithelial cells of the choroid plexus.

Aliases & Classifications for Choroid Plexus Carcinoma

About this section

Choroid Plexus Carcinoma, Aliases & Descriptions:

Name: Choroid Plexus Carcinoma 8 42 10 62
Malignant Neoplasm of the Choroid Plexus 8 62
Malignant Neoplasm of Choroid Plexus 8 62
Malignant Tumor of Choroid Plexus 8 62
Tumor of the Choroid Plexus 8 62
 
Cancer of Choroid Plexus 8 62
Tumor of Choroid Plexus 8 62
Choroid Plexus Cancer 8 22
Choroid Plexus Neoplasms 62
Choroid Plexus Tumors 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:5648, DOID:3540
NCIt39 C4533, C3473
MeSH34 D016545

Related Diseases for Choroid Plexus Carcinoma

About this section

Diseases in the Choroid Plexus Carcinoma family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma31.1TP53
2rhabdoid tumor31.0SMARCB1, SYP
3ependymoma30.7PDGFRA, SYP
4adrenocortical carcinoma30.7TP53, ADM, SYP
5pilocytic astrocytoma30.5PDGFRB, SYP
6rhabdomyosarcoma30.0SMARCB1, TP53, PDGFRA, PDGFRB
7glioblastoma multiforme30.0TP53, ADM, PDGFRA, PDGFRB
8osteosarcoma29.9PDGFRB, PDGFRA, CA2, TP53
9glioblastoma29.7SMARCB1, TP53, ADM, PDGFRA, PDGFRB
10astrocytoma29.6PDGFRB, PDGFRA, CA2, SYP, TP53
11leukemia29.4SMARCA4, TP53, PDGFRA, PDGFRB
12choroiditis11.2
13dysembryoplastic neuroepithelial tumor10.5SYP
14pineoblastoma10.4SYP
15subependymal giant cell astrocytoma10.4SYP
16atypical teratoid rhabdoid tumor10.4
17meningitis10.4
18adult choroid plexus cancer10.3
19childhood choroid plexus cancer10.3
20gliosarcoma10.3PDGFRB
21papilloma10.3
22acute lymphoblastic leukemia10.2
23li-fraumeni syndrome10.2
24disseminated intravascular coagulation10.2
25lymphoblastic leukemia10.2
26rhabdoid tumors, somatic10.2
27endolymphatic sac tumor10.2
28adrenal cortical adenoma10.2SYP, ADM
29prion disease10.2SYP
30arteriosclerosis10.2ADM, PDGFRA
31bone marrow cancer10.1PDGFRA, PDGFRB
32chondrosarcoma10.1PDGFRB, PDGFRA
33desmoid tumor10.1PDGFRB, PDGFRA
34systemic mastocytosis10.1PDGFRB, PDGFRA
35endometrial stromal sarcoma10.1PDGFRA, PDGFRB
36hypereosinophilic syndrome10.1PDGFRA, PDGFRB
37pdgfrb-associated chronic eosinophilic leukemia10.1PDGFRB, PDGFRA
38chordoma10.1PDGFRB, PDGFRA
39mastocytosis10.1PDGFRA, PDGFRB
40myelofibrosis10.1PDGFRA, PDGFRB
41meningioma10.1SMARCB1, SYP, PDGFRB
42polycythemia vera10.1PDGFRA, PDGFRB
43gastrointestinal stromal tumor10.0PDGFRA, PDGFRB
44neurilemmoma10.0PDGFRB, PDGFRA, SMARCB1
45pancreatic cancer10.0PDGFRB, CA2, SYP
46brain cancer10.0PDGFRB, SYP, TP53
47neurofibroma10.0SYP, PDGFRA, PDGFRB
48tuberous sclerosis10.0PDGFRB, SYP
49esophageal cancer10.0PDGFRB, TP53
50lung small cell carcinoma10.0PDGFRA, SYP, TP53

Graphical network of the top 20 diseases related to Choroid Plexus Carcinoma:



Diseases related to choroid plexus carcinoma

Symptoms for Choroid Plexus Carcinoma

About this section

Drugs & Therapeutics for Choroid Plexus Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Choroid Plexus Carcinoma

Search NIH Clinical Center for Choroid Plexus Carcinoma

Genetic Tests for Choroid Plexus Carcinoma

About this section

Genetic tests related to Choroid Plexus Carcinoma:

id Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma22

Anatomical Context for Choroid Plexus Carcinoma

About this section

MalaCards organs/tissues related to Choroid Plexus Carcinoma:

32
Bone marrow, Bone

Animal Models for Choroid Plexus Carcinoma or affiliated genes

About this section

Publications for Choroid Plexus Carcinoma

About this section

Articles related to Choroid Plexus Carcinoma:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. (25106865)
2014
2
Gross total resection improves overall survival in children with choroid plexus carcinoma. (24166581)
2014
3
Response to combined radiotherapy and chemotherapy of a leptomeningeal spread from choroid plexus carcinoma: case report. (25308727)
2014
4
Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant. (23427033)
2013
5
Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. (23151741)
2013
6
Coincident choroid plexus carcinoma and adrenocortical tumor in an infant. (22752623)
2013
7
The cytologic findings in choroid plexus carcinoma: report of a case with differential diagnosis. (22180231)
2012
8
Imatinib mesylate treatment for platelet-derived growth factor receptor alfa-positive choroid plexus carcinoma. (24765448)
2012
9
A rare case of congenital choroid plexus carcinoma. (22881717)
2012
10
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. (21442238)
2011
11
Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil. (21445348)
2011
12
Melanotic choroid plexus carcinoma of the posterior fossa. (21779301)
2011
13
Invasive pneumococcal disease following treatment for choroid plexus carcinoma. (20076974)
2010
14
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. (20515336)
2010
15
Choroid plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier. (21070306)
2010
16
Choroid plexus carcinoma: report of two cases. (19679976)
2009
17
Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report. (19834361)
2009
18
Choroid plexus carcinoma. (18684041)
2008
19
Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. (18762572)
2008
20
Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report. (16723819)
2006
21
Images in neuro-oncology: choroid plexus carcinoma. (16794748)
2006
22
Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations. (15925506)
2005
23
Choroid plexus carcinoma in the adult: is there a role for chemotherapy? (16270538)
2005
24
Successful treatment of an unresectable choroid plexus carcinoma in a patient with Li-Fraumeni syndrome. (15654279)
2005
25
Successful therapy of choroid plexus carcinoma. (15236288)
2004
26
Choroid plexus carcinoma presented with spinal dysfunction caused by a drop metastasis: a case report. (12814258)
2003
27
Efficacy of sequential chemotherapy including methotrexate and doxorubicin in an infant with partially resected choroid plexus carcinoma. (12476023)
2003
28
Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer. (11800650)
2002
29
Primary choroid plexus carcinoma producing carbohydrate antigen 19-9. (11128618)
2000
30
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
31
Magnetic resonance imaging of a choroid plexus carcinoma and meningeal carcinomatosis in a dog. (10519302)
1999
32
Radiation therapy and survival in choroid plexus carcinoma. (10382700)
1999
33
Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. (9595484)
1998
34
Choroid plexus carcinoma in an infant. (9170025)
1997
35
Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems. (8878450)
1996
36
Endoreduplication and telomeric association in a choroid plexus carcinoma. (8646745)
1996
37
The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. (7737660)
1995
38
Choroid plexus carcinoma in the lateral ventricle--case report. (8532130)
1995
39
Choroid plexus carcinoma of the lateral ventricle. Report of a case in an adult. (8187382)
1994
40
Magnetic resonance imaging in a dog with choroid plexus carcinoma. (8286551)
1993
41
Primary choroid plexus carcinoma in an infant. Report of a case evaluated by MRI. (1306205)
1992
42
Current management of choroid plexus carcinoma in children. (1822687)
1991-1992
43
Choroid plexus carcinoma in siblings. (2307984)
1990
44
Choroid plexus carcinoma in a dog. (2723160)
1989
45
Choroid plexus carcinoma of the fourth ventricle. Report of a case in an infant. (3075286)
1988
46
Choroid plexus carcinoma: report of a case with radiographic and ultrastructure correlation. (3710847)
1986
47
The fine structure of choroid plexus carcinoma. (6662512)
1983
48
Choroid plexus carcinoma. Report of a case with immunohistochemical and ultrastructural observations. (6821827)
1983
49
Choroid plexus carcinoma in a child: a case report. (539483)
1979
50
Choroid plexus carcinoma--a case report. (1028945)
1976

Variations for Choroid Plexus Carcinoma

About this section

Expression for genes affiliated with Choroid Plexus Carcinoma

About this section
Expression patterns in normal tissues for genes affiliated with Choroid Plexus Carcinoma

Search GEO for disease gene expression data for Choroid Plexus Carcinoma.

Pathways for genes affiliated with Choroid Plexus Carcinoma

About this section

Pathways related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.7SMARCA4, SMARCB1
29.7SMARCA4, SMARCB1
39.6PDGFRA, PDGFRB
49.6PDGFRB, PDGFRA
5
Show member pathways
PDGF Pathway37
9.6PDGFRB, PDGFRA
69.4PDGFRA, TP53
7
Show member pathways
9.0SMARCB1, SMARCA4, TP53
89.0TP53, PDGFRA, PDGFRB
99.0PDGFRB, PDGFRA, TP53
109.0PDGFRB, PDGFRA, TP53
119.0PDGFRB, PDGFRA, TP53
129.0TP53, PDGFRA, PDGFRB
13
Show member pathways
MAPK signaling pathway37
9.0TP53, PDGFRA, PDGFRB
14
Show member pathways
Signaling Pathways in Glioblastoma37
9.0PDGFRB, PDGFRA, TP53
15
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0TP53, PDGFRA, PDGFRB
16
Show member pathways
9.0TP53, PDGFRA, PDGFRB
179.0PDGFRB, PDGFRA, TP53
18
Show member pathways
9.0TP53, PDGFRA, PDGFRB
19
Show member pathways
8.2PDGFRB, PDGFRA, TP53, SMARCA4, SMARCB1

Compounds for genes affiliated with Choroid Plexus Carcinoma

About this section

Compounds related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1dmpq dihydrochloride6110.0PDGFRA, PDGFRB
2su 16f6110.0PDGFRA, PDGFRB
3su 66686110.0PDGFRA, PDGFRB
4sunitinib malate6110.0PDGFRA, PDGFRB
5pkc 4124410.0PDGFRA, PDGFRB
6ag-1296449.9PDGFRB, PDGFRA
7pazopanib50 1110.9PDGFRB, PDGFRA
8sunitinib44 50 1111.9PDGFRB, PDGFRA
9regorafenib50 1110.9PDGFRB, PDGFRA
10streptozotocin449.7SYP, ADM
11ang ii449.7ADM, PDGFRB
12norepinephrine44 24 1111.6CA2, SYP, ADM
13dutp449.6TP53, ADM, SYP
14topotecan44 1110.5TP53, PDGFRB
15calcitriol44 61 24 1112.5PDGFRB, PDGFRA, CA2
16depsipeptide449.5PDGFRB, TP53
17phosphotyrosine449.5PDGFRB, PDGFRA, SYP
18histidine449.4SMARCA4, SYP, CA2
19flavopiridol44 1110.4PDGFRB, TP53
20cyclic amp44 2410.3CA2, SYP, ADM, SMARCA4
21actinomycin d449.2CA2, ADM, TP53
22steroid449.2SMARCA4, ADM, SYP, CA2
23testosterone44 61 24 1112.1SMARCA4, ADM, SYP, PDGFRB
24h2o2449.1TP53, ADM, SYP, PDGFRB
25arginine448.9SMARCA4, TP53, ADM, CA2
26cysteine448.8PDGFRB, CA2, SYP, ADM, SMARCA4
27lipid448.8SMARCA4, ADM, SYP, CA2, PDGFRB
28atp44 289.8SMARCA4, ADM, CA2, PDGFRA, PDGFRB
29paraffin448.7TP53, ADM, SYP, PDGFRA, PDGFRB
30proline448.7PDGFRB, CA2, TP53
31vegf448.7PDGFRB, PDGFRA, SYP, ADM, TP53
32progesterone44 28 61 24 1112.6PDGFRB, SYP, ADM, TP53, SMARCA4
33tyrosine448.4SMARCA4, ADM, SYP, CA2, PDGFRA, PDGFRB
34retinoic acid44 249.4TP53, ADM, SYP, CA2, PDGFRA, PDGFRB
35oligonucleotide448.2SMARCA4, TP53, ADM, CA2, PDGFRA, PDGFRB
36estrogen447.8PDGFRB, SMARCA4, TP53, ADM, SYP, CA2

GO Terms for genes affiliated with Choroid Plexus Carcinoma

About this section

Cellular components related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1npBAF complexGO:0715649.7SMARCA4, SMARCB1
2SWI/SNF complexGO:0165149.7SMARCA4, SMARCB1
3nBAF complexGO:0715659.6SMARCA4, SMARCB1
4intrinsic component of plasma membraneGO:0312269.3PDGFRB, PDGFRA

Biological processes related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:0018359.9SMARCA4, SMARCB1
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:0380919.9PDGFRB, PDGFRA
3metanephric glomerular capillary formationGO:0722779.9PDGFRB, PDGFRA
4positive regulation by host of viral transcriptionGO:0439239.9SMARCA4, SMARCB1
5retina vasculature development in camera-type eyeGO:0612989.9PDGFRA, PDGFRB
6positive regulation of phospholipase C activityGO:0108639.9PDGFRA, PDGFRB
7nucleosome disassemblyGO:0063379.9SMARCA4, SMARCB1
8cardiac myofibril assemblyGO:0550039.9PDGFRB, PDGFRA
9adrenal gland developmentGO:0303259.8PDGFRA, PDGFRB
10positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRB, PDGFRA
11platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRA, PDGFRB
12odontogenesis of dentin-containing toothGO:0424759.7ADM, CA2, PDGFRA
13vasculogenesisGO:0015709.6ADM, SMARCA4
14cell chemotaxisGO:0603269.6PDGFRB, PDGFRA
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5PDGFRA, PDGFRB
16positive regulation of reactive oxygen species metabolic processGO:20003799.5TP53, PDGFRB
17in utero embryonic developmentGO:0017019.2PDGFRB, PDGFRA, TP53
18negative regulation of cell proliferationGO:0082858.9ADM, TP53, SMARCB1

Molecular functions related to Choroid Plexus Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.7PDGFRB, PDGFRA
2Tat protein bindingGO:0309579.7SMARCB1, SMARCA4
3platelet-derived growth factor bindingGO:0484079.5PDGFRB, PDGFRA
4platelet-derived growth factor receptor bindingGO:0051619.3PDGFRA, PDGFRB
5p53 bindingGO:0020399.1TP53, SMARCA4, SMARCB1
6protein bindingGO:0055157.5PDGFRB, PDGFRA, CA2, ADM, TP53, SMARCA4

Products for genes affiliated with Choroid Plexus Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Choroid Plexus Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet