MCID: CHR008
MIFTS: 57

Choroiditis malady

Summaries for Choroiditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

MalaCards: Choroiditis, also known as choroiditis nos, is related to choroid plexus papilloma and papilloma. An important gene associated with Choroiditis is SLC46A1 (solute carrier family 46 (folate transporter), member 1), and among its related pathways is the visual cycle I (vertebrates). The compounds cysteine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are homeostasis/metabolism and vision/eye.

Aliases & Classifications for Choroiditis

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

choroiditis 8 42 60
choroiditis nos 8


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Disease Ontology8 DOID:11406
SNOMED-CT56 193449000, 16553002
MeSH34 D002833

Related Diseases for Choroiditis

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17GeneCards, 18GeneDecks
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Diseases related to Choroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 548)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma31.4S100B, CT49, SYP, IGF2, MUC1, TTR
2papilloma31.4CT49
3choroid plexus carcinoma31.1SMARCB1
4melanoma31.1TIMP3, S100B, CT49
5age related macular degeneration31.0TIMP3, CFH
6glaucoma30.5TTR
7vitelliform macular dystrophy30.3TIMP3, PRPH2
8retinal degeneration30.3TIMP3, PRPH2, CHM, ABCA4, GFAP, OAT
9retinal disease30.3TIMP3, PRPH2, CHM, ABCA4, GFAP
10adenocarcinoma30.3TIMP3, CT49, SYP, MUC1
11meningioma30.3S100B, CT49, SYP, IGF2, MUC1, GFAP
12partial central choroid dystrophy30.3TIMP3, PRPH2
13hepatitis30.1TTR
14adenoma29.9TIMP3, CT49, SYP, IGF2, MUC1
15retinoblastoma29.9SMARCB1, GFAP, SYP, CT49
16ganglioneuroma29.9S100B, SYP, GFAP
17atypical teratoid rhabdoid tumor29.9SMARCB1
18papillary ependymoma29.8GFAP, SYP, S100B
19paraganglioma29.8S100B, SYP, GFAP
20primary open angle glaucoma29.8ABCA4
21parkinson's disease29.8CHM
22neurilemmoma29.8SMARCB1, GFAP
23medulloblastoma29.6TIMP3, S100B, CT49, SYP, IGF2, GFAP
24glioblastoma multiforme29.5SMARCB1, GFAP, CT49, S100B, TIMP3
25leiomyosarcoma29.5S100B, IGF2, MUC1, SMARCB1
26hemangioblastoma29.5S100B, SYP, MUC1, GFAP
27sarcoma29.5S100B, IGF2, MUC1, SMARCB1
28brain cancer29.5CT49, SYP, GFAP, SMARCB1
29hemangiopericytoma29.5S100B, IGF2, MUC1
30ganglioglioma29.5GFAP, SYP, S100B
31eye disease29.5OAT, ABCA4, CHM
32rhabdomyosarcoma29.5SMARCB1, IGF2, S100B
33cone-rod dystrophy 229.5ABCA4, PRPH2, TIMP3
34neurofibroma29.5MUC1, SYP, S100B
35chondrosarcoma29.5S100B, MUC1
36leiomyoma29.5IGF2, S100B
37olfactory neuroblastoma29.5S100B, SYP
38giant cell glioblastoma29.5GFAP
39clear cell sarcoma29.5IGF2, S100B
40primary hyperoxaluria29.5CFH, TTR, CT49, TIMP3
41proliferative diabetic retinopathy29.5TIMP3, GFAP
42fibrosarcoma29.5TIMP3
43retinitis10.8
44gyrate atrophy10.8
45choroid disease10.7
46angioid streaks10.6
47coloboma10.6
48retinal detachment10.5
49myopia10.5
50angioid streaks of choroid10.5

Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to choroiditis

Clinical Features for Choroiditis

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Drugs & Therapeutics for Choroiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choroiditis

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Anatomical Context for Choroiditis

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32MalaCards
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MalaCards organs/tissues related to Choroiditis:

32
Retina, Eye, Endothelial, Brain, Thyroid, Bone, Skin, Lung, Breast, Testes, Prostate, Ovary, Pineal, T cells, B cells, Pituitary, Bone marrow, Cortex, Smooth muscle, Hypothalamus, Ciliary ganglion, Temporal lobe, Cerebellum, Spinal cord, Skeletal muscle, Colon, Kidney, Liver, Salivary gland

Animal Models for Choroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.6MUC1, IGF2, CHM, HTR2C, TIMP3, ABCA4
2MP:000539112.3OAT, TIMP3, OPTC, PRPH2, CHM, IGF2
3MP:000363112.1PRPH2, SYP, CHM, IGF2, ABCA4, GFAP
4MP:000538511.6TIMP3, OPTC, PRPH2, CHM, IGF2, ABCA4
5MP:000118611.4TIMP3, HTR2C, PRPH2, CHM, ABCA4, OAT

Publications for Choroiditis

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50PubMed
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Articles related to Choroiditis:

(show top 50)    (show all 2143)
idTitleAuthorsYear
1
Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy. (24412124)
2014
2
Choroidal thickness in relation to hypercholesterolemia on enhanced depth imaging optical coherence tomography. (23089893)
2013
3
Intravitreal anti-VEGF therapy for choroidal neovascularisation secondary to pathological myopia: 4-year outcome. (24026146)
2013
4
Comparative analysis of repeatability of manual and automated choroidal thickness measurements in nonneovascular age-related macular degeneration. (23538060)
2013
5
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. (23514267)
2013
6
Serpiginous choroiditis and acute retinal necrosis occurring in the same patient. (23571247)
2013
7
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
8
Distal anterior choroidal artery aneurysm following iatrogenic posterior cerebral artery occlusion : a case report and review of literature. (22068715)
2012
9
Pigmented free-floating vitreous cyst in a patient with high myopia and uveal coloboma simulating choroidal melanoma. (21485975)
2011
10
Choroidal neovascularization associated with coloboma of the choroid: a series of three cases. (21350286)
2011
11
Choroidal metastasis from primary pulmonary leiomyosarcoma. (22452689)
2011
12
Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. (21336069)
2011
13
Primary choroid plexus papilloma in the pituitary fossa: case report and literature review. (21140177)
2011
14
CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (20574013)
2010
15
Choroid plexus failure in the Kearns-Sayre syndrome. (20731822)
2010
16
Choroid plexus papilloma with osseous metaplasia as a differential diagnosis of calcifying pseudoneoplasms of the neuraxis. (20395381)
2010
17
Severe choroidal ischemia following photodynamic therapy for pigment epithelial detachment and chronic central serous chorioretinopathy. (19184311)
2009
18
Choroiditis in a patient with multiple sclerosis. (19065419)
2008
19
Treatment of serpiginous choroiditis with intravitreous fluocinolone acetonide implant. (18569797)
2008
20
Association of LOC387715 A69S with vitreous hemorrhage in polypoidal choroidal vasculopathy. (18400199)
2008
21
Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. (17890782)
2007
22
Choroid plexus papilloma developing in a dermoid cyst of ovary. (16879402)
2006
23
Detection of BRAF gene mutation in primary choroidal melanoma tissue. (16410717)
2006
24
Verteporfin photodynamic therapy of choroidal neovascularization secondary to ocular toxoplasmosis. (16682600)
2006
25
Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. (16172982)
2005
26
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. (16181294)
2005
27
Ocular photodynamic therapy in choroidal neovascularization complicating idiopathic central serous chorioretinopathy. (15088832)
2004
28
Choroidal neovascularization after central retinal vein occlusion in a 47-year-old man. (15364727)
2004
29
Pineal region lesion masquerading choroid plexus papilloma: case report. (12648913)
2003
30
Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl. (11879139)
2002
31
Choroid plexus papilloma of the fourth ventricle. (12593575)
2002
32
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
33
Choroidal infiltrates simulating fundal changes of acute leukemia during hematological recovery following high-dose chemotherapy in acute myelomonocytic leukemia in remission. (10602168)
2000
34
nm23 Expression in choroidal melanoma. (11015036)
2000
35
Gyrate atrophy of the choroid and retina: a case report]. (11033500)
2000
36
Mortality in patients with small choroidal melanoma. COMS report no. 4. The Collaborative Ocular Melanoma Study Group. (9230829)
1997
37
Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas. (7795732)
1995
38
Management of retinal detachment associated with choroidal coloboma using perfluoroperhydrophenanthrene (Vitreon). (1508487)
1992
39
Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. (1703384)
1990
40
Superotemporal coloboma of the iris, ciliary body, and choroid. (3177581)
1988
41
Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina. (3922397)
1985
42
Bilateral nodular sarcoid choroiditis with vitreous haemorrhage. (6205681)
1984
43
Choroidal neovascularization in long-standing case of Vogt-Koyanagi-Harada disease. (6190031)
1983
44
Angiography of malignant choroid plexus papilloma. (5314210)
1971
45
Choroid plexus meningioma of the lateral ventricle: two cases demonstrated by brain scanning. (5300176)
1968
46
Treatment of active toxoplasmic retino-choroiditis. (5301644)
1968
47
Gyrate atrophy of choroid and retina. (20260315)
1947
48
Summarized Reports of Eight Cases of Coloboma of Iris and Choroid (Congenital). (19989749)
1934
49
ANGIOID STREAKS, AND THEIR RELATION TO A FORM OF CENTRAL CHOROIDAL DISEASE. (18168957)
1931
50
Patches of Choroiditis at the Maculae, Secondary to Double Antral Suppuration. (19985571)
1927

Genetic Variations for Choroiditis

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Expression for genes affiliated with Choroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroiditis

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Pathways for genes affiliated with Choroiditis

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Choroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.8TTR, ABCA4

Compounds for genes affiliated with Choroiditis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Choroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1cysteine4412.9CFH, TIMP3, S100B, HTR2C, CT49, OPTC
2retinoic acid44 2413.4TIMP3, S100B, CT49, SYP, IGF2, MUC1
3serine4412.3S100B, HTR2C, CT49, SYP, IGF2, MUC1
4paraffin4412.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
5testosterone44 59 11 2415.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
6dexamethasone44 49 28 1115.2TIMP3, S100B, SYP, IGF2, MUC1, TTR
7glutamate4412.2TIMP3, S100B, HTR2C, SYP, IGF2, TTR
8estrogen4412.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
9lipid4412.2TIMP3, S100B, HTR2C, SYP, CHM, MUC1
10tyrosine4412.1TIMP3, S100B, HTR2C, SYP, IGF2, MUC1
11glutamine4412.1TIMP3, S100B, SYP, IGF2, TTR, GFAP
12progesterone44 59 28 11 2416.0TIMP3, S100B, CT49, SYP, IGF2, MUC1
13vegf4412.0TIMP3, S100B, CT49, SYP, IGF2, MUC1
14glucose4412.0TIMP3, S100B, IGF2, MUC1, TTR, GFAP
15estradiol44 11 2413.9TIMP3, CT49, SYP, IGF2, MUC1, GFAP
16creatinine4411.8S100B, SYP, IGF2, MUC1, TTR, GFAP
17cholesterol44 28 11 2414.8SYP, MUC1, ABCA4, TTR, GFAP, CFH
18arginine4411.8TIMP3, S100B, IGF2, TTR, GFAP, OAT
19zinc44 2412.8S100B, CT49, IGF2, TTR, GFAP, CFH
20alanine4411.7S100B, CT49, IGF2, TTR, GFAP, CFH
21dbc-amp4411.7TIMP3, S100B, SYP, IGF2, GFAP
22acth4411.7GFAP, MUC1, IGF2, SYP, S100B
23agar4411.7GFAP, TTR, MUC1, IGF2, CT49
24gaba4411.7S100B, HTR2C, SYP, GFAP, OAT
25norepinephrine44 11 2413.7S100B, HTR2C, SYP, IGF2, TTR
26glycogen44 2412.6S100B, SYP, IGF2, MUC1, GFAP
27dopamine44 28 11 2414.6S100B, HTR2C, SYP, TTR, GFAP
28cisplatin44 49 59 1114.6SYP, IGF2, MUC1, GFAP, CFH
29thymidine44 2412.6S100B, CT49, IGF2, MUC1, GFAP
30s 1004411.6S100B, SYP, MUC1, GFAP
31reticulin4411.6S100B, SYP, MUC1, GFAP
32aspartate4411.6S100B, PRPH2, TTR, GFAP, OAT
33hematoxylin4411.5S100B, SYP, MUC1, GFAP
34adenylate4411.5S100B, HTR2C, IGF2, TTR, GFAP
35formaldehyde44 2412.5S100B, SYP, MUC1, GFAP
36eosin4411.4S100B, MUC1, GFAP
37mucicarmine4411.4S100B, SYP, MUC1
38b 7234411.3S100B, SYP, MUC1
39methionine4411.3TIMP3, S100B, TTR, GFAP
40forskolin44 49 1113.2GFAP, CT49
41guanidine hydrochloride4411.2TTR, MUC1, IGF2
42ethanol44 49 11 2414.2S100B, SYP, MUC1, GFAP
43lithium44 49 11 2414.2MUC1, SYP, HTR2C
44silver4411.1CT49, SYP, GFAP
45phospholipid4411.1ABCA4, MUC1, SYP, S100B
46polyethylene glycol4411.1GFAP, MUC1, IGF2
47n-acetylaspartate4411.1GFAP, SYP
48acetylcholine44 49 28 11 2415.0S100B, HTR2C, SYP, GFAP
49glycosaminoglycan4411.0CFH, IGF2, TIMP3
502,3-cyclic nucleotide4410.5GFAP, S100B

GO Terms for genes affiliated with Choroiditis

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16Gene Ontology
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Biological processes related to Choroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.0OAT, ABCA4, CHM, PRPH2, TIMP3
2cellular response to organic substanceGO:07131010.8SYP, TIMP3

Products for genes affiliated with Choroiditis

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Sources for Choroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet