Choroiditis malady

Wikipedia: Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina...⁴⁴ more...

MalaCards: Choroiditis, also known as choroiditis nos (disorder), is related to carcinoma and retinitis. An important gene associated with Choroiditis is CACD (central areolar choroidal dystrophy), and among its related pathways are PTEN Pathway and ILK Signaling. The compounds estrogen and vegf have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cerebellum, and related mouse phenotypes are nervous system and growth/size.

Aliases & Descriptions:

choroiditis 6 30 8 43 choroiditis nos (disorder) 6

choroiditis (disorder) 6 choroiditis nos 6

Diseases related to choroiditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1061)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	49.2	PIK3CG, LRP2, KLF5, NCAM1, NCOR2, CNTF
2	retinitis	44.2	PIK3CG, LRP2, CNTF, CNTFR, VWF, VTN
3	melanoma	42.8	PIK3CG, KLF5, NCAM1, CNTF, VWF, VTN
4	neuronitis	41.3	PIK3CG, LRP2, NCAM1, NCOR2, CNTF, CNTFR
5	macular degeneration	39.3	CNTF, VWF, VTN, VSX1, SELE, SERPINF1
6	age related macular degeneration	39.0	VTN, SELE, SERPINF1, SERPINE1, SERPING1, VLDLR
7	prostatitis	37.3	PIK3CG, LRP2, KLF5, NCAM1, NCOR2, CNTF
8	papilloma	36.7	PCNA, RBL1, VIM, BRAF, VEGFA, RARB
9	hypoxia	36.5	PIK3CG, KLF5, VWF, VTN, PCNA, SELE
10	choroid plexus carcinoma	36.4	CA2, TP53, SMARCA4, SMARCB1, PLS1, PDGFRA
11	choroid plexus papilloma	36.1	MUC1, S100B, IGF2, GFAP, TTR, TAG
12	choroidal dystrophy	35.1	RCVRN, SERPINF1, ARRB2, CACD, CACD3, AIPL1
13	breast carcinoma	34.8	PIK3CG, VWF, VTN, SFN, RCVRN, PCNA
14	thyroiditis	34.7	PIK3CG, LRP2, NCAM1, NCOR2, VWF, VTN
15	cerebritis	34.4	PIK3CG, LRP2, NCAM1, CNTF, VWF, VTN
16	ependymoma	34.3	NCAM1, VTN, VIM, VEGFA, RARB, RASSF1
17	partial central choroid dystrophy	34.2	UNC119, GUCA1A, GUCY2D, PITPNA, ABCA4, TIMP3
18	hypertension	33.7	PIK3CG, KLF5, NCAM1, VWF, PCNA, SELE
19	chorioretinitis	33.0	SERPINF1, PAX6, CHM, SAG, IGF2, HLA-B
20	meningioma	32.7	PIK3CG, NCAM1, PCNA, SELE, SETD2, SERPINE1
21	intraocular melanoma	32.2	BRAF, S100B, MMP2, MDM2, ENG, ANXA5
22	alzheimer's disease	32.2	PIK3CG, LRP2, NCAM1, CNTF, CNTFR, KIAA0913
23	coloboma	32.0	VSX2, RAX, PAX6, GUCY2D, AIPL1, CRB1
24	rhabdoid tumors	32.0	NCAM1, VIM, MYC, RASSF1, PAX3, MUC1
25	maculopathy	31.9	VWF, SELE, SERPINF1, BEST1, CFB, CFH
26	atypical teratoid rhabdoid tumor	31.9	VIM, RASSF1, MUC1, IGF2, HSP90AA1, TP53
27	retinal degeneration	31.9	CNTF, RCVRN, SERPINF1, BMP6, RAB6A, RABGGTB
28	astrocytoma	31.7	PIK3CG, NCAM1, VTN, PCNA, RBL1, SETD2
29	meningitis	31.2	PIK3CG, NCAM1, PCNA, SELE, VIM, VIP
30	retinoblastoma	31.0	PIK3CG, NCAM1, VSX2, RCVRN, PCNA, RBL1
31	osteosarcoma	30.5	PIK3CG, VWF, VTN, PCNA, RBL1, SETD2
32	choroid cancer	30.1	CNTFR, YIPF3, IFITM2, KRTAP1-3, KRTAP1-1
33	cataract	29.7	VSX2, PCNA, SERPINF1, VIM, VEGFA, BMP6
34	skin melanoma	29.4	PCNA, S100B, CDKN1A, CD36, MMP2, MKI67
35	adrenocortical carcinoma	29.4	VIP, MKI67, IGF2, CALB2, TP53, CYP19A1
36	diabetic retinopathy	29.4	PIK3CG, VWF, VTN, SELE, SETD2, SERPINF1
37	ataxia	29.3	PIK3CG, LRP2, KIAA0913, VWF, RCVRN, PCNA
38	ocular melanoma	29.3	SERPINF1, VIM, VEGFA, BMP6, S100B, ANXA5
39	thyroid cancer	29.3	PIK3CG, LRP2, PCNA, VIM, BRAF, VEGFA
40	neuroendocrine tumor	29.2	NCAM1, VIP, RAF1, RASSF1, CDX2, MKI67
41	posterior uveal melanoma	28.3	PCNA, BRAF, VEGFA, BIRC5, MMP9, MKI67
42	age-related maculopathy	28.2	CFH, APOE, CTSD, ABCA4, TIMP3
43	multiple sclerosis	28.1	NCAM1, CNTF, VWF, VTN, PCNA, SELE
44	intracranial hypertension	27.7	SERPINE1, IL1B, F5, ALB, HSD11B1, TNF
45	uveitis	27.6	RCVRN, SELE, SERPINF1, VEGFA, BMP6, LCN2
46	vasculitis	27.1	VWF, SELE, SERPING1, VEGFA, VCAM1, BMP6
47	hypogonadism	27.1	SERPINE1, LEPR, ATXN2, CD36, FOLH1, INS
48	amyloidosis	27.0	VWF, VTN, BCL2, B2M, FURIN, ITM2B
49	diabetic ketoacidosis	26.9	VWF, INS, IL10, F5, ICAM1, ALB
50	choroideremia	26.8	RAB6A, RAB1A, RAB27B, RAB3A, RAB27A, RABGGTB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to choroiditis:

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MGI Mouse Phenotypes related to choroiditis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	17.9	CNTF, CNTFR, VWF, VSX1, VSX2, RBL1
2	growth/size phenotype	MP:0005378	17.1	PIK3CG, LRP2, KLF5, NCOR2, SFN, RBL1
3	vision/eye phenotype	MP:0005391	16.8	LRP2, NCAM1, VSX1, VSX2, SFN, RCVRN
4	cardiovascular system phenotype	MP:0005385	15.7	PIK3CG, KLF5, NCOR2, VWF, RBL1, SELE
5	immune system phenotype	MP:0005387	15.2	KLF5, CNTF, VWF, SFN, RBL1, SERPINB9
6	behavior/neurological phenotype	MP:0005386	15.0	LRP2, NCAM1, NCOR2, CNTF, CNTFR, VSX1
7	digestive/alimentary phenotype	MP:0005381	14.0	LRP2, KLF5, NCOR2, VWF, SFN, RBL1
8	normal phenotype	MP:0002873	13.9	KLF5, VTN, RBL1, SELE, SERPING1, VIP
9	embryogenesis phenotype	MP:0005380	13.4	KLF5, SFN, RBL1, SETD2, VIM, BRAF
10	renal/urinary system phenotype	MP:0005367	13.4	LRP2, BRAF, MYLK, BMP7, RARB, PAX3
11	skeleton phenotype	MP:0005390	13.1	PIK3CG, LRP2, SFN, RBL1, BRAF, VEGFA
12	endocrine/exocrine gland phenotype	MP:0005379	13.0	LRP2, KLF5, VSX2, SFN, RBL1, PAX3
13	reproductive system phenotype	MP:0005389	12.9	VSX2, SFN, RBL1, SERPINF1, VIP, VEGFA
14	respiratory system phenotype	MP:0005388	12.9	LRP2, KLF5, RAB3A, PAX3, PAX6, PAM
15	integument phenotype	MP:0010771	12.9	PIK3CG, SFN, RBL1, BRAF, MYC, RAB27B
16	muscle phenotype	MP:0005369	12.8	PIK3CG, KLF5, CNTF, RBL1, VIM, BRAF
17	liver/biliary system phenotype	MP:0005370	12.2	NCOR2, SFN, RBL1, VEGFA, CHRM2, UACA
18	limbs/digits/tail phenotype	MP:0005371	12.1	SFN, RBL1, VEGFA, BMP7, RARB, PAX3
19	no phenotypic analysis	MP:0003012	12.1	LRP2, VSX2, PCNA, RBL1, VEGFA, VCAM1
20	craniofacial phenotype	MP:0005382	12.0	LRP2, NCOR2, RBL1, RAX, PAX3, PAX6
21	pigmentation phenotype	MP:0001186	11.6	VSX2, SERPINF1, VLDLR, BRAF, MYC, BMP7
22	tumorigenesis	MP:0002006	11.0	SFN, RBL1, SERPINE1, BRAF, MYC, RASSF1
23	hearing/vestibular/ear phenotype	MP:0005377	10.9	LRP2, SFN, MYC, BMP7, RARB, USH2A
24	other phenotype	MP:0005395	10.6	RARB, KDR, LEPR, LDLR, LAMA2, MME
25	adipose tissue phenotype	MP:0005375	10.2	NCOR2, RBL1, SERPINE1, VLDLR, BRAF, MYC
26	mortality/aging	MP:0010768	INF	KLF5, NCAM1, NCOR2, CNTFR, VWF, VSX2
27	hematopoietic system phenotype	MP:0005397	INF	CNTF, SFN, PCNA, RBL1, SERPINB9, BRAF
28	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CG, LRP2, KLF5, NCOR2, CNTF, VWF
29	cellular phenotype	MP:0005384	INF	PIK3CG, LRP2, KLF5, NCAM1, NCOR2, CNTF

Articles related to choroiditis:

(show top 50)    (show all 386)

id	Title	Authors	Year	Affiliating Genes
1	Influence of Dll4 via HIF-1I+-VEGF signaling on the an giogenesis of choroidal neovascularization under hypoxic conditions. (21526177)	Dong X.... Zhang J.	2011	DLL4
2	Association of elastin gene polymorphism to age-relat ed macular degeneration and polypoidal choroidal vasculopathy. (22003121)	Yamashiro K.... Yoshimura N.	2011	ELN
3	A dominant mutation in RPE65 identified by whole-exom e sequencing causes retinitis pigmentosa with choroidal involvement. (21654732)	Bowne S.J.... Humphries P.	2011	RPE65
4	Annexin A2 promotes choroidal neovascularization by i ncreasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization. (20368092)	Zhao S.H.... Xu Y.	2010	KDR, ANXA5, ANXA2
5	Toll-Like Receptor 3 Polymorphism rs3775291 Is Not As sociated with Choroidal Neovascularization or Polypoidal Choroidal Vasculopathy in Chinese Subjects. (21079408)	Sng C.C.... Vithana E.N.	2010	TLR3
6	SERPING1 polymorphisms in polypoidal choroidal vascul opathy. (20161815)	Li M.... Luo G.	2010	SERPING1
7	The role of vascular endothelial growth factor-induce d activation of NADPH oxidase in choroidal endothelial cells and choroidal neov ascularization. (20802176)	Monaghan-Benson E.... Hartnett M.E.	2010	VEGFA
8	Immunohistochemical analysis of CDX2 expression in no rmal choroid plexus epithelium and choroid plexus tumors. (19795349)	Beschorner R.... Schittenhelm J.	2009	SOX9, CDX2
9	Are intravitreal bevacizumab and ranibizumab effectiv e in a rat model of choroidal neovascularization? (18781316)	Lu F.... Adelman R.A.	2009	VEGFA
10	Clinical features and linkage analysis for a Chinese family with autosomal dominant central areolar choroidal dystrophy. (19951596)	Ma K.... Liu N.P.	2009	AIPL1
11	Early effects of intravitreal triamcinolone acetonide on inflammation and proliferation in human choroidal neovascularization. (19273790)	Tatar O.... Grisanti S.	2009	ICAM1, VEGFA, SELE
12	Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium. (19283393)	Beschorner R.... Schittenhelm J.	2009	SLC1A3, SLC1A2, GFAP
13	5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway. (18634756)	Quintela T.... Santos C.R.	2008	TTR
14	Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour. (19114013)	Greenwood S.... Ferretti P.	2008	FGF2
15	Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (18326737)	Kondo N.... Negi A.	2008	ELN
16	Autoantibodies against bestrophin in a patient with vitelliform paraneoplastic retinopathy and a metastatic choroidal malignant melanoma. (18332332)	Eksandh L.... Andreasson S.	2008	BEST1
17	Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes. (18486097)	Wakusawa R.... Nishida K.	2008	VWF, VASH1
18	The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages. (18689706)	Schroedl F.... Cursiefen C.	2008	LYVE1
19	Molecular mechanism of choroidal neovascularization in age-related macular degeneration (18051818)	Yoshida T.	2007	MME, SERPINF1
20	Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid. (17662275)	Radeke M.J.... Anderson D.H.	2007	CCL26
21	Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. (17389522)	Tanito M.... Anderson R.E.	2007	RHO
22	Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. (16490490)	Tong J.P.... Lam D.S.	2006	VEGFA, SERPINF1
23	A novel role for the choroid plexus in BMP-mediated i nhibition of differentiation of cerebellar neural progenitors. (16325379)	Krizhanovsky V.... Ben-Arie N.	2006	BMP7
24	Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions. (16409998)	Tong J.P.... Yao Y.F.	2006	VEGFA, SERPINF1
25	Detection of BRAF gene mutation in primary choroidal melanoma tissue. (16410717)	Malaponte G.... Travali S.	2006	BRAF
26	Gender and estrogen supplementation increases severit y of experimental choroidal neovascularization. (15721623)	Espinosa-Heidmann D.G.... Cousins S.W.	2005	NOS2
27	Carboxyamido-triazole modulates retinal pigment epith elial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells. (15814468)	Hoffmann S.... Kohn E.C.	2005	MMP2, FGF2, VEGFA
28	Chromosomal abnormalities, p53 and Bcl-2 expression and clinical outcome in choroidal melanoma. (15577317)	Erol N.... Yurdakul S.	2004	TP53, BCL2
29	Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy. (15148217)	Matsuoka M.... Matsumura M.	2004	SERPINF1
30	Apolipoprotein E polymorphisms in Japanese patients with polypoidal choroidal vasculopathy and exudative age-related macular degeneration. (15488782)	Gotoh N.... Yoshimura N.	2004	APOE
31	Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization. (12692592)	Gehlbach P.... Campochiaro P.A.	2003	SERPINF1
32	Nerve growth factor regulates human choroidal, but not retinal, endothelial cell migration and proliferation. (14614965)	Steinle J.J.... Granger H.J.	2003	NGF
33	Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites. (14737013)	Alebouyeh M.... Endou H.	2003	SLC22A6
34	Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase. (12795815)	Hurley J.H.... Yu L.	2003	MAPK10, GPBAR1
35	Expression of neuropilin-1 in choroidal neovascular membranes. (12608516)	Cui J.Z.... Matsubara J.A.	2003	NRP1
36	Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials. (12766088)	Lambert V.... Rakic J.M.	2003	VTN
37	Targeting of interferon to choroidal neovascularization by use of dextran and metal coordination. (11867606)	Yasukawa T.... Ogura Y.	2002	IFNB1
38	Expression of estrogen receptor in the choroidal neov ascular membranes in highly myopic eyes. (12172107)	Kobayashi K.... Okinami S.	2002	ESR1, VIM
39	Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children. (11837741)	Carlotti C.G.... Rutka J.T.	2002	E2F1, RBL1
40	Ophthalmologic heterogeneity in subjects with gyrate atrophy of choroid and retina harboring the L402P mutation of ornithine aminotransferase. (11297489)	Peltola K.E.... Nikoskelainen E.	2001	OAT
41	Regulation effect of vascular endothelial growth fact or on human fetal choroid vascularization. (12579722)	Zhao J.... Zhang X.	2000	PCNA
42	Role of muscarinic cholinergic transmission in Edinger-Westphal nucleus-induced choroidal vasodilation in pigeon. (10712818)	Zagvazdin Y.... Reiner A.	2000	CHRM2
43	Usefulness of synaptophysin immunohistochemistry in an adult case of choroid plexus carcinoma. (10935220)	Kohmura E.... Yoshimine T.	2000	SYP
44	Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. (10874668)	Gyure K.A.... Morrison A.L.	2000	S100B, MUC1, TTR
45	Choroid plexus epithelium (normal and neoplastic) expresses synaptophysin. A potentially useful aid in differentiating carcinoma of the choroid plexus from metastatic papillary carcinomas. (10218635)	Kepes J.J.... Collins J.	1999	SYP
46	The effect of interferon-beta on experimental choroidal neovascularization (7540359)	Tobe T.... Uyama M.	1995	IFNB1
47	The AgNOR technique, PCNA immunohistochemistry, and DNA ploidy in the evaluation of choroid plexus biopsy specimens. (7902669)	Centeno B.A.... Sobel R.A.	1993	PCNA
48	Increased expression and mutation of p53 in choroidal melanoma. (1419633)	Tobal K.... Lightman S.	1992	TP53
49	Evidence for retinal pathology following interruption of neural regulation of choroidal blood flow: Muller cells express GFAP following lesions of the nucleus of Edinger-Westphal in pigeons. (2201485)	Fitzgerald M.E.... Reiner A.	1990	GFAP
50	5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor. (2164094)	Tsutsumi M.... Sanders-Bush E.	1990	HTR1A, HTR2A

Genes related to choroiditis according to GeneCards:

(show top 50)    (show all 471)

id	Symbol	Description	Score	GeneCards Section Context
1	CACD	central areolar choroidal dystrophy	11.0	Aliases & Descriptions, Publications
2	CACD3	Choroidal dystrophy, central areolar 3	11.0	Aliases & Descriptions
3	CHM	choroideremia (Rab escort protein 1)	11.0	Summaries
4	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Summaries
5	OPTC	opticin	11.0	Summaries
6	SLC46A1	solute carrier family 46 (folate transporter), member 1	11.0	Summaries
7	SLC4A10	solute carrier family 4, sodium bicarbonate transporter, member 10	11.0	Summaries
8	PRPH2	peripherin 2 (retinal degeneration, slow)	11.0	Publications
9	GFAP	glial fibrillary acidic protein	11.0	Publications
10	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
11	TTR	transthyretin	11.0	Publications, Expressions
12	S100B	S100 calcium binding protein B	11.0	Publications
13	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
14	TP53	tumor protein p53	11.0	Publications
15	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
16	PITPNA	phosphatidylinositol transfer protein, alpha	11.0
17	SYP	synaptophysin	11.0	Publications
18	PLS1	plastin 1	11.0	Publications
19	CFH	complement factor H	11.0	Publications
20	ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	11.0	Publications
21	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
22	TAG	tumor antigen gene	11.0	Publications
23	MUC1	mucin 1, cell surface associated	11.0	Publications
24	VIM	vimentin	11.0	Publications
25	ARMS2	age-related maculopathy susceptibility 2	11.0	Publications
26	KRTAP1-1	keratin associated protein 1-1	10.9
27	OAT	ornithine aminotransferase	10.9	Publications
28	ZMYND10	zinc finger, MYND-type containing 10	10.9	Publications
29	YIPF3	Yip1 domain family, member 3	10.9
30	HTRA1	HtrA serine peptidase 1	10.9	Publications
31	RCVRN	recoverin	10.9	Publications
32	AIPL1	aryl hydrocarbon receptor interacting protein-like 1	10.9	Publications
33	CFB	complement factor B	10.9	Publications
34	CYP4V2	cytochrome P450, family 4, subfamily V, polypeptide 2	10.9	Publications
35	ENG	endoglin	10.9	Publications
36	CA2	carbonic anhydrase II	10.9	Publications
37	ANGPT2	angiopoietin 2	10.9	Publications
38	PGF	placental growth factor	10.9	Publications
39	ADM	adrenomedullin	10.9	Publications
40	C5AR1	complement component 5a receptor 1	10.9	Publications
41	ARRB2	arrestin, beta 2	10.9	Publications
42	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	10.9	Publications
43	CTGF	connective tissue growth factor	10.9	Publications
44	TEK	TEK tyrosine kinase, endothelial	10.9	Publications
45	ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	10.9
46	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	10.9	Publications
47	PDGFB	platelet-derived growth factor beta polypeptide	10.9	Publications
48	VEGFA	vascular endothelial growth factor A	10.9	Publications
49	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	10.9
50	THBS1	thrombospondin 1	10.9	Publications

Pathways related to choroiditis according to GeneDecks:

(show top 50)    (show all 133)

id	Pathway	Score	Top Affiliating Genes
1	PTEN Pathway36	12.5	BRAF, VEGFB, BMP7, KDR, LAMA2, LAMB2
2	ILK Signaling36	12.4	VIM, VEGFB, BMP7, KDR, LAMA2, LAMB2
3	Molecular Mechanisms of Cancer36	12.3	PIK3CG, RBL1, MYC, BMP6, BMP7, RARB
4	Paxillin Interactions36	12.1	VEGFB, KDR, ITGAV, ITGB4, FLT1, FGF2
5	Phospholipase-C Pathway36	12.0	VEGFB, BMP6, BMP7, RAF1, KDR, LAMA2
6	Rho Family GTPases36	12.0	VIM, VEGFB, MYLK, BMP6, BMP7, RAF1
7	Akt Signaling36	11.9	PIK3CG, VEGFB, BMP7, RAF1, ITGB4, MERTK
8	Angiogenesis3	11.9	VEGFB, KDR, ITGAV, MMP2, MMP9, FLT1
9	Intracellular Calcium Signaling36	11.9	VEGFB, BMP6, BMP7, KDR, ATP2B2, FLT1
10	Apoptotic Pathways in Synovial Fibroblasts36	11.7	VEGFB, BMP6, BMP7, KDR, FLT1, FGF2
11	p38 Signaling36	11.6	VEGFB, BMP6, BMP7, KDR, BCL2, FLT1
12	Antioxidant Action of Vitamin-C36	11.6	VEGFB, BMP6, BMP7, KDR, BCL2, FLT1
13	Rac1 Pathway36	11.6	VEGFB, BMP6, BMP7, RAF1, KDR, ITGAV
14	p53 Mediated Apoptosis36	11.6	VEGFB, BMP6, BMP7, KDR, BCL2, FLT1
15	Telomerase Components in Cell Signaling36	11.6	VEGFB, MYC, BMP6, BMP7, KDR, FLT1
16	Ras Pathway36	11.6	BRAF, VEGFB, BMP7, RAF1, KDR, ITGAV
17	Glioma Invasiveness36	11.5	VTN, VEGFB, BMP6, BMP7, CD44, ITGAV
18	ERK Signaling36	11.5	BRAF, VEGFB, MYC, MYLK, BMP6, BMP7
19	Cytokine-cytokine receptor interaction20	11.5	CNTF, CNTFR, VEGFA, VEGFB, BMP7, KDR
20	Focal adhesion20	11.5	PIK3CG, VWF, VTN, BRAF, VEGFB, MYLK
21	Nanog in Mammalian ESC Pluripotency36	11.4	BRAF, VEGFB, BMP6, BMP7, RAF1, KDR
22	JNK Pathway36	11.4	VEGFB, BMP6, BMP7, RAF1, KDR, BCL2
23	PPAR Pathway36	11.4	VEGFB, RAF1, ITGAV, ITGB4, FLT1, FGF2
24	DHA Signaling36	11.4	SERPINF1, VEGFB, BMP6, BMP7, KDR, BCL2
25	Tec Kinases Signaling36	11.3	VEGFB, BMP6, BMP7, BCL2, ITGAV, ITGB4
26	Breast Cancer Regulation by Stathmin136	11.3	VEGFB, BMP7, RAF1, FGF2, FGF5, FGFR2
27	Transendothelial Migration of Leukocytes36	11.3	VCAM1, MYLK, CLDN2, CLDN11, LAMA2, LAMB2
28	Pathways in cancer20	11.3	PIK3CG, VEGFA, VEGFB, MYC, RARB, RASSF1
29	Estrogen Pathway36	11.3	NCOR2, BRAF, VEGFB, BMP6, BMP7, RAF1
30	p70S6K Signaling36	11.2	VEGFB, BMP6, BMP7, RAF1, KDR, FLT1
31	TGF-Beta Pathway36	11.2	VEGFB, BMP6, BMP7, KDR, BCL2, CDH1
32	MAPK Signaling36	11.2	BRAF, VEGFB, MYC, BMP6, BMP7, RAF1
33	ERK5 Signaling36	11.2	VEGFB, MYC, BMP6, BMP7, KDR, FOXO3
34	Renin-Angiotensin Pathway36	11.1	VEGFB, VCAM1, BMP6, BMP7, RAF1, KDR
35	PAK Pathway36	11.1	VEGFB, MYLK, BMP6, BMP7, KDR, BCL2
36	JAK-STAT Pathway36	11.1	VEGFB, MYC, BMP6, BMP7, RAF1, KDR
37	Neuroscience3	11.1	NCAM1, SAG, S100B, APP, ENO2, HTR1A
38	eIF2 Pathway36	11.1	BRAF, BMP6, BMP7, RAF1, INS, FGF2
39	Mitochondrial Apoptosis36	11.0	VEGFB, BMP6, BMP7, KDR, BCL2, FLT1
40	MAPK Family Pathway36	11.0	BRAF, VEGFB, BMP6, BMP7, RAF1, KDR
41	Pancreatic Adenocarcinoma36	11.0	BRAF, VEGFB, BMP6, BMP7, RAF1, BIRC5
42	Bladder cancer20	10.9	BRAF, VEGFA, VEGFB, MYC, RAF1, RASSF1
43	eNOS Signaling36	10.9	BMP6, BMP7, GUCY2D, FGF5, FGFR2, MERTK
44	Cellular Apoptosis Pathway36	10.9	VEGFB, BMP6, BMP7, KDR, BCL2, FLT1
45	Activation of PKC through GPCR36	10.8	VEGFB, BMP6, BMP7, RAF1, KDR, FLT1
46	Glioblastoma Multiforme36	10.8	BRAF, RAF1, CDKN1A, CDKN1B, MGMT, MDM2
47	STAT3 Pathway36	10.1	BRAF, MYC, BMP6, BMP7, RAF1, BCL2
48	Endothelin-1 Signaling Pathway36	10.1	BRAF, MYC, BMP6, BMP7, RAF1, FLT1
49	Prostate cancer20	10.1	PIK3CG, BRAF, RAF1, BCL2, CDKN1A, CDKN1B
50	14-3-3 Induced Intracellular Signaling36	INF	VEGFB, BMP7, RAF1, FLT1, FGF2, FGF5

Compounds related to choroiditis according to GeneDecks:

(show top 50)    (show all 485)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	14.0	KLF5, NCOR2, VWF, PCNA, SETD2, SERPINB9
2	vegf32	13.9	PIK3CG, NCAM1, CNTF, VWF, VTN, PCNA
3	retinoic acid32 42 18	15.2	PIK3CG, LRP2, NCAM1, NCOR2, CNTF, CNTFR
4	progesterone32 42 9 18 9	17.1	NCAM1, NCOR2, CNTF, PCNA, SETD2, BRAF
5	phospholipid32	12.9	LRP2, VWF, RCVRN, VLDLR, CHRM2, LDLR
6	heparin32 9 18 9	15.5	PIK3CG, LRP2, NCAM1, VWF, VTN, SERPINF1
7	threonine32	12.4	SET, MYLK, RAF1, CHRM2, CDKN1B, ARRB2
8	histamine32 18	13.1	NCAM1, CNTF, VWF, PCNA, SELE, VIM
9	ascorbic acid32 18	13.1	PIK3CG, CNTF, PCNA, SETD2, BMP7, RAF1
10	forskolin32 42 9 9	14.9	CNTF, VIM, VIP, BRAF, MYLK, BMP6
11	potassium32 9 18 9	14.9	NCAM1, CNTF, VTN, RCVRN, SERPINF1, VIP
12	dexamethasone32 42 34 9 9	15.8	NCAM1, VWF, VTN, PCNA, SERPINF1, SERPINE1
13	gaba32 42	12.8	NCAM1, CNTF, VIM, VIP, BLVRB, CHRM2
14	h2o232	11.7	PIK3CG, CNTF, VWF, VIP, LEPR, LDLR
15	glyceraldehyde 3-phosphate32	11.6	SETD2, BIRC5, UCHL1, B2M, MMP1, FLT1
16	cisplatin32 34 9 9	14.5	VTN, PCNA, SETD2, BRAF, VEGFA, MYC
17	doxorubicin32 34 9 9	14.4	PIK3CG, NCAM1, SELE, SETD2, VIM, BMP6
18	p00332	11.4	SERPINE1, RASSF1, MVP, MTRR, S100B, CDKN1B
19	retinoid32	11.3	NCOR2, VIM, MYC, BMP6, RARB, BCL2
20	p00232	11.2	BRAF, BIRC5, MVP, MTHFR, CD44, CDH1
21	paclitaxel32 34 9 9	14.2	PIK3CG, PCNA, SETD2, VIM, BRAF, VEGFA
22	wortmannin32 42	12.2	PIK3CG, CNTF, VTN, SETD2, VIM, BRAF
23	sodium nitroprusside32	11.2	VWF, PCNA, VIP, BMP6, BLVRB, S100B
24	butyrate32	11.1	RCVRN, PCNA, SETD2, VIM, MYC, BMP6
25	isoproterenol32 9 9	13.0	VIM, BRAF, RAF1, CHRM2, ARRB2, FGF2
26	cyclophosphamide32 34 9 9	14.0	MVP
27	pravastatin32 34 9 18 9	14.9	SELE, SERPINE1, LDLR, CETP, APOA1, APOE
28	norepinephrine32 9 18 9	13.8	CNTF, VWF, SELE, VIP, VCAM1, BMP6
29	cytochalasin d32 42	11.7	PIK3CG, VWF, VTN, SELE, VIM, VCAM1
30	sb 20358032 42	11.6	SELE, SETD2, VIM, BRAF, VEGFA, VCAM1
31	cyclosporin a32 42	11.6	PIK3CG, VWF, VIP, MYC, RAF1, MVP
32	12-o-tetradecanoylphorbol 13-acetate32	10.6	NCAM1, CNTF, BRAF, MYC, BMP6, RARB
33	gefitinib32 34 9 9	13.5	PIK3CG, VIM, VEGFA, BIRC5, KDR, CDKN1A
34	guanine32 9 18 9	13.4	VWF, SELE, SETD2, VIP, RAF1, RAB5A
35	atorvastatin32 34 9 18 9	14.4	VWF, SELE, VEGFA, VCAM1, BMP6, LDLR
36	ly29400232	10.4	PIK3CG, VTN, SELE, VEGFA, CDKN1B, CD44
37	genistein32 9 18 9	13.4	PIK3CG, CNTF, PCNA, SELE, SETD2, SERPINE1
38	celecoxib32 42 34 9 18 9	15.3	PIK3CG, PCNA, VEGFA, BIRC5, KDR, BCL2
39	simvastatin32 34 42 9 18 9	15.3	VWF, SELE, SERPINE1, VEGFA, VCAM1, BMP6
40	betacarotene32	10.2	VWF, PCNA, RARB, MTHFR, CETP, MMP1
41	docetaxel32 34 9 9	13.2	SETD2, VEGFA, MYC, RAF1, BIRC5, KDR
42	ibmx32	10.2	VIP, VCAM1, RARB, RAF1, MME, MMP2
43	mg 13232 42	10.9	PIK3CG, NCOR2, PCNA, MYC, BIRC5, KDR
44	ns 39832 42	10.9	PIK3CG, PCNA, CDKN1B, MMP1, FGF2, IL1B
45	tacrolimus32 34 9 9	12.8	VTN, PCNA, SERPINE1, MYC, BMP6, RAF1
46	ciglitazone32	9.5	SERPINE1, RARB, CDKN1A, CDKN1B, MMP2, MMP9
47	troglitazone32 42 9 9	11.9	PIK3CG, SELE, SERPINE1, VCAM1, BMP6, BIRC5
48	curcumin32	8.7	PIK3CG, VTN, VEGFA, VCAM1, MYC, RAF1
49	lipid32	INF	PIK3CG, LRP2, NCAM1, NCOR2, CNTF, CNTFR
50	camptothecin32 42 9 9	INF	PIK3CG, PCNA, SETD2, MYC, BIRC5, KDR

Cellular components related to choroiditis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	15.4	NOS1, PLS1, PLCG1, SMTN, SNAI1, PPP1R1B
2	extracellular region	GO:005576	13.7	CALCA, PLTP, COL8A1, COL18A1, COL4A4, COL9A1
3	integral to plasma membrane	GO:005887	13.4	FOLR1, HTR2A, HOMER1, HLA-A, HLA-B, HLA-C
4	extracellular space	GO:005615	13.2	CNTF, CFH, CFP, CETP, FURIN, CD5L
5	membrane	GO:016020	12.5	SLCO2A1, SLC22A3, SLC2A1, SLC28A1, SLC22A1, SYT17
6	basolateral plasma membrane	GO:016323	11.6	SLC22A8, SLC22A6, SLC2A1, SLC1A3, SLC4A2, SLC9A1
7	extracellular matrix	GO:031012	11.6	TNC, TNXB, CTSD, COL8A1, COL18A1, SHH
8	cell surface	GO:009986	10.7	PDGFB, NTRK2, TEK, TNF, CA4, HSPB1
9	apical plasma membrane	GO:016324	10.7	PDGFRB, ABCC6, THY1, TF, STC1, SLC4A5
10	platelet alpha granule lumen	GO:031093	10.6	F5, ALB, F13A1, PDGFB, THBS1, TGFB1
11	external side of plasma membrane	GO:009897	10.6	ANXA5, ICAM1, HLA-DRB1, TNF, ACE, THBS1
12	plasma membrane	GO:005886	INF	ENPP2, ICAM1, HTR1A, HTR2A, HTR2C, F2
13	Golgi apparatus	GO:005794	INF	RHO, CTGF, PTGS1, PTGDS, ESR1, CA4

Biological processes related to choroiditis according to GeneDecks:

(show top 50)    (show all 60)

id	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:007601	13.3	VSX1, VSX2, RCVRN, RABGGTB, RAX, RABGGTA
2	angiogenesis	GO:001525	12.5	PIK3CG, KLF5, SETD2, SERPINE1, VEGFA, VASH1
3	positive regulation of angiogenesis	GO:045766	12.3	SERPINE1, VEGFA, KDR, MMP9, FLT1, FGF2
4	positive regulation of endothelial cell proliferation	GO:001938	12.0	VEGFA, VEGFB, BMP6, KDR, FGF2, CCL26
5	signal transduction	GO:007165	12.0	CNTF, CNTFR, SFN, RCVRN, VLDLR, RARB
6	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.9	VSX2, RBL1, SERPINE1, VEGFA, MYC, BMP6
7	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.8	NCOR2, VLDLR, MYC, RARB, KANK2, CD36
8	vascular endothelial growth factor receptor signaling pathway	GO:048010	11.7	VEGFA, VEGFB, KDR, FLT1, CCL2, NRP1
9	cell-cell signaling	GO:007267	11.6	BARX1, MPZL1, INS, FGF5, FGFR2, MERTK
10	cellular response to hypoxia	GO:071456	11.6	VLDLR, VEGFA, BMP7, KCNK3, AQP1, MDM2
11	response to wounding	GO:009611	11.6	VWF, PAX6, ITGB4, FN1, F2, TNC
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.5	BRAF, VEGFB, KDR, CD44, ARRB2, FGF2
13	positive regulation of cell migration	GO:030335	11.5	VEGFA, MYLK, KDR, FURIN, ITGAV, FLT1
14	positive regulation of cell division	GO:051781	11.5	VEGFA, VEGFB, FGF2, FGF5, FGFR2, IL1B
15	positive regulation of cell proliferation	GO:008284	11.5	KLF5, CNTF, CNTFR, VSX2, VIP, VEGFA
16	blood circulation	GO:008015	11.4	SERPING1, MTHFR, F5, DLL4, EDN3, ELN
17	immune response	GO:006955	11.3	VTN, SERPINB9, BMP6, SBSPON, SAMHD1, CFP
18	organ morphogenesis	GO:009887	11.3	BRAF, PAX3, PAX6, BCL2, CDX2, FGF2
19	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:043154	11.2	SFN, SERPINB9, VEGFA, RAF1, BIRC5, CD44
20	negative regulation of cell proliferation	GO:008285	11.2	VSX2, SFN, RARB, RAF1, KANK2, CDKN1A
21	chemotaxis	GO:006935	11.1	FGF2, ENPP2, MAPK1, MAP2K1, CCL26, CCR6
22	cell adhesion	GO:007155	11.1	NCAM1, VWF, VTN, VCAM1, SCARB2, LAMA2
23	response to organic cyclic compound	GO:014070	11.1	CDKN1A, ENO2, ANGPT2, ICAM1, PTGS2, CTGF
24	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.1	VTN, VEGFA, VEGFB, CD36, CD44, INS
25	negative regulation of apoptotic process	GO:043066	11.1	PIK3CG, SERPINE1, BRAF, VEGFA, MYC, RAF1
26	response to hypoxia	GO:001666	11.1	VEGFA, VCAM1, RAF1, PAM, BCL2, MMP9
27	positive regulation of endothelial cell migration	GO:010595	11.0	VEGFA, KDR, ANXA3, ANGPT1, TEK, NRP1
28	negative regulation of blood vessel endothelial cell migration	GO:043537	11.0	VASH1, FGF2, APOE, ANGPT2, DLL4, THBS1
29	blood coagulation	GO:007596	11.0	PIK3CG, VWF, SERPINE1, SERPING1, VEGFA, VEGFB
30	positive regulation of blood vessel endothelial cell migration	GO:043536	11.0	VEGFA, FGF2, ANGPT1, PLCG1, PDGFB, THBS1
31	sodium-independent organic anion transport	GO:043252	11.0	ALB, SLCO2A1, SLCO1A2, SLC22A6, SLCO1C1, SLCO1B3
32	positive regulation of MAP kinase activity	GO:043406	10.9	PIK3CG, VEGFA, FLT1, HTR2A, TNF, PDGFB
33	organ regeneration	GO:031100	10.9	LRP2, CDKN1A, MKI67, ANGPT2, ANXA3, ANGPT1
34	platelet degranulation	GO:002576	10.9	VWF, SERPINE1, SERPING1, VEGFA, VEGFB, CD36
35	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.8	CNTF, KDR, FLT1, INS, ANGPT1, IGF1
36	response to drug	GO:042493	10.8	LRP2, VLDLR, MYC, PAM, BCL2, KCNK3
37	positive regulation of protein kinase B signaling cascade	GO:051897	10.8	PIK3CG, VEGFB, ARRB2, INS, ANGPT1, GPX1
38	platelet activation	GO:030168	10.8	PIK3CG, VWF, SERPINE1, SERPING1, VEGFA, VEGFB
39	positive regulation of protein phosphorylation	GO:001934	10.8	VEGFA, IL1B, ENG, IGF2, F2, TNF
40	anti-apoptosis	GO:006916	10.8	SERPINB9, BRAF, VEGFB, BIRC5, BCL2, MUC1
41	inflammatory response	GO:006954	10.5	PIK3CG, SELE, BMP6, IL10, IL1B, IL8
42	response to glucocorticoid stimulus	GO:051384	10.5	SERPINF1, SERPINE1, PAM, IL10, IL1B, ANXA3
43	virus-host interaction	GO:019048	10.5	RBL1, VIM, VCAM1, KDR, LDLR, MPDZ
44	positive regulation of mitosis	GO:045840	10.4	INS, IL1B, IGF2, IGF1, TNF, PDGFB
45	positive regulation of fibroblast proliferation	GO:048146	10.3	MYC, CDKN1A, AQP1, IGF1, PDGFB, PDGFRA
46	cytokine-mediated signaling pathway	GO:019221	10.3	NCAM1, VCAM1, B2M, CD44, IL1B, CCL2
47	positive regulation of gene expression	GO:010628	10.2	BRAF, VEGFA, PAX6, CD44, CTGF, NTRK2
48	positive regulation of MAPK cascade	GO:043410	10.2	CNTF, KDR, CD36, FLT1, INS, FGFR2
49	response to estradiol stimulus	GO:032355	10.2	PAM, MMP9, IL1B, ENO2, ESR1, PTGS2
50	transmembrane transport	GO:055085	INF	ATP2B2, FXYD2, AQP1, APOA1, ALB, ABCA4

Molecular functions related to choroiditis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	13.4	SHH, PLCG1, CRP, SMARCB1, SMARCA4, SNAI1
2	receptor binding	GO:005102	11.5	CX3CL1, EDN3, PDGFRB, NOS2, PPP1R1B, CXCL12
3	growth factor activity	GO:008083	11.2	PROK1, TGFB1, PDGFB, NGF, CXCL12, CSF2
4	transcription factor binding	GO:008134	11.2	HIF1A, AHR, TWIST1, SLC9A1, ADD1, E2F1
5	integrin binding	GO:005178	11.1	SRC, CTGF, GFAP, TIMP2, THBS1, THY1
6	protein heterodimerization activity	GO:046982	11.0	PDGFB, HIF1A, AHR, TYR, TWIST1, TOP2B
7	heparin binding	GO:008201	11.0	TNXB, CTGF, NRP1, THBS1, PRELP, PGF
8	identical protein binding	GO:042802	10.9	ESR1, HSP90AA1, APP, APOE, TP53, TP73
9	hormone activity	GO:005179	10.3	TTR, TG, STC1, NPPA, ADM, EDN3