MCID: CHR008
MIFTS: 47

Choroiditis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Choroiditis

MalaCards integrated aliases for Choroiditis:

Name: Choroiditis 12 72 49 41 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:11406
ICD10 32 H30.9
MeSH 41 D002833
NCIt 46 C35111
SNOMED-CT 64 16553002 193449000
UMLS 69 C0008526

Summaries for Choroiditis

MalaCards based summary : Choroiditis is related to central serous chorioretinopathy and punctate inner choroidopathy. An important gene associated with Choroiditis is ARMS2 (Age-Related Maculopathy Susceptibility 2), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Pertussis. The drugs Dexamethasone and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial.

Wikipedia : 72 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Choroiditis

Diseases related to Choroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 883)
# Related Disease Score Top Affiliating Genes
1 central serous chorioretinopathy 32.5 ARMS2 CFH
2 punctate inner choroidopathy 31.8 IL10 TNF
3 panuveitis 31.6 IL10 TNF
4 posterior uveitis 31.6 CFH TNF
5 multifocal choroiditis 31.1 ARMS2 CFB CFH HTRA1 IL10 TNF
6 retinal disease 30.3 ARMS2 CFB CFH
7 intermediate uveitis 30.2 IL10 TNF
8 eales disease 30.2 IL10 TNF
9 macular degeneration, age-related, 1 30.1 ARMS2 CFB CFH HTRA1 TNF
10 anterior uveitis 29.8 CFH TNF
11 toxoplasmosis 29.8 IL10 TNF
12 prostatitis 29.6 IL10 TNF
13 meningitis 29.4 IL10 TNF
14 lyme disease 29.4 CFH TNF
15 acquired immunodeficiency syndrome 29.1 IL10 TNF
16 chlamydia 29.1 IL10 TNF
17 cytomegalovirus infection 29.0 IL10 TNF
18 complex regional pain syndrome 29.0 IL10 TNF
19 rubella 28.9 IL10 TNF
20 allergic contact dermatitis 28.9 IL10 TNF
21 contact dermatitis 28.9 IL10 TNF
22 toxic shock syndrome 28.8 IL10 TNF
23 peritonitis 28.8 IL10 TNF
24 degeneration of macula and posterior pole 28.6 ARMS2 CFB CFH HTRA1
25 nervous system disease 28.5 CFH IL10 TNF
26 papilloma of choroid plexus 12.5
27 choroidal dystrophy, central areolar, 1 12.4
28 gyrate atrophy of choroid and retina 12.4
29 choroid plexus cancer 12.4
30 choroid disease 12.3
31 serpiginous choroiditis 12.3
32 choroid plexus cyst 12.2
33 choroidal dystrophy, central areolar 2 12.1
34 ataxia - hypogonadism - choroidal dystrophy 12.1
35 choroid spindle cell melanoma 12.1
36 atypical choroid plexus papilloma 12.0
37 choroid plexus meningioma 12.0
38 malignant choroid melanoma 12.0
39 choroidal osteoma, bilateral 12.0
40 hereditary choroidal atrophy 12.0
41 choroid necrotic melanoma 12.0
42 choroideremia 11.9
43 choroidal dystrophy, central areolar, 3 11.9
44 birdshot chorioretinopathy 11.9
45 adult choroid plexus cancer 11.9
46 choroid mixed cell melanoma 11.9
47 partial central choroid dystrophy 11.9
48 childhood choroid plexus cancer 11.8
49 choroid epithelioid cell melanoma 11.8
50 partial circumpapillary choroid dystrophy 11.8

Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to Choroiditis

Symptoms & Phenotypes for Choroiditis

Drugs & Therapeutics for Choroiditis

Drugs for Choroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
3 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
4 Hormones Phase 4,Phase 3,Phase 2,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
6 Antiemetics Phase 4,Phase 3,Phase 2
7 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
9 Autonomic Agents Phase 4,Phase 3,Phase 2
10 BB 1101 Phase 4,Phase 3,Phase 2
11 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
12 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
13 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
14 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
15 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17
protease inhibitors Phase 4,Phase 3,Phase 2
18 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
19 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Adrenocorticotropic Hormone Phase 4
21 beta-endorphin Phase 4
22 Melanocyte-Stimulating Hormones Phase 4
23
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
24
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
25
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
26
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
27
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
28
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
29
Mycophenolic acid Approved Phase 3 24280-93-1 446541
30
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
31
Methotrexate Approved Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
32
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
33
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 3 67-73-2 6215
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 3,Phase 1,Phase 2 58-05-9 143 6006
36 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
37 Anti-Infective Agents Phase 3,Phase 2,Phase 1
38 Antimalarials Phase 3
39 Antiparasitic Agents Phase 3
40 Antiprotozoal Agents Phase 3
41 Clindamycin palmitate Phase 3
42 Clindamycin phosphate Phase 3
43 Folic Acid Antagonists Phase 3,Phase 1,Phase 2
44 Methylprednisolone acetate Phase 3
45 Methylprednisolone Hemisuccinate Phase 3
46 Neuroprotective Agents Phase 3
47 Prednisolone acetate Phase 3
48 Prednisolone hemisuccinate Phase 3
49 Prednisolone phosphate Phase 3
50 Protective Agents Phase 3

Interventional clinical trials:

(show all 35)

# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
4 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
5 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
6 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
7 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
8 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
9 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin
10 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
11 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Active, not recruiting NCT03097315 Phase 3
12 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3 FAI insert
13 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
14 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
15 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Active, not recruiting NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
16 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
17 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
18 Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis , Completed NCT01526889 Phase 2 LFG316;Conventional Therapy
19 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
20 Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis Completed NCT01552044 Phase 1, Phase 2 Spironolactone;Placebo
21 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
22 Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a Completed NCT00508040 Phase 2 interferon alpha 2a;prednisone
23 Intravitreal Sirolimus as Therapeutic Approach to Uveitis Recruiting NCT01280669 Phase 2 Intravitreal injection 440mcg;Intravitreal injection of sirolimus 880mcg
24 Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Active, not recruiting NCT01717170 Phase 1, Phase 2 Tocilizumab
25 Safety and Preliminary Efficacy Study of V404 PDS in Uveitis Terminated NCT02125266 Phase 1, Phase 2 V404
26 Safety &Efficacy of CF101 to Subjects With Uveitis Withdrawn NCT01905124 Phase 2 CF101;Placebo
27 Sirolimus as Therapeutic Approach to Uveitis Unknown status NCT00908466 Phase 1 Sirolimus (rapamycin);Sirolimus (rapamycin)
28 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
29 Retisert and Cataract Surgery in Patients With Severe Uveitis Completed NCT00570830
30 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
31 Quality of Life in Patients With Intermediate Uveitis Completed NCT01314469
32 Extension Study of Patients With Non-infectious Uveitis Who Participated in CLS1001-301 Enrolling by invitation NCT02952001
33 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Not yet recruiting NCT02879084
34 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy
35 Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Withdrawn NCT01151462

Search NIH Clinical Center for Choroiditis

Cochrane evidence based reviews: choroiditis

Genetic Tests for Choroiditis

Anatomical Context for Choroiditis

MalaCards organs/tissues related to Choroiditis:

38
Retina, Eye, Endothelial, Brain, Testes, Lung, Thyroid

Publications for Choroiditis

Articles related to Choroiditis:

(show top 50) (show all 2750)
# Title Authors Year
1
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
2
Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients. ( 29318448 )
2018
3
EDI OCT evaluation of choroidal thickness in Stargardt disease. ( 29304098 )
2018
4
PRN Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis. ( 29304262 )
2018
5
Clinicopathologic Features of Tuberculous Serpiginous-like Choroiditis. ( 29270629 )
2018
6
CHORIOCAPILLARIS FLOW VOIDS IN CRYPTOCOCCAL CHOROIDITIS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. ( 29373342 )
2018
7
Chromatic and achromatic visual fields in relation to choroidal thickness in patients with high myopia: A pilot study. ( 29396209 )
2018
8
Comparison of hydrocephalus metrics between infants successfully treated with endoscopic third ventriculostomy with choroid plexus cauterization and those treated with a ventriculoperitoneal shunt: a multicenter matched-cohort analysis. ( 29393809 )
2018
9
Risk Factors for Developing Choroidal Neovascular Membrane and Visual Loss in Punctate Inner Choroidopathy. ( 28993011 )
2018
10
INTRAVITREAL AFLIBERCEPT IN THE TREATMENT OF POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH MORNING GLORY SYNDROME. ( 29324624 )
2018
11
Choroidal thickness changes following cataract surgery using swept source optical coherence tomography. ( 29426443 )
2018
12
Intravitreal aflibercept for the treatment of choroidal neovascularization associated with rubella retinopathy. ( 29411259 )
2018
13
Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma. ( 29443364 )
2018
14
Is Nonarteritic Ischemic Optic Neuropathy Due to Choroidal Compression of the Prelaminar Neurovascular Compartment of the Optic Nerve Head? ( 29438261 )
2018
15
Results of external beam radiotherapy for diffuse choroidal hemangiomas in Sturge-Weber syndrome. ( 29403070 )
2018
16
Quantitative polymerase chain reaction analysis of serpiginous choroiditis with biopsy-proven testicular tuberculosis. ( 29380793 )
2018
17
Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations. ( 28763560 )
2017
18
Efficacy and safety of conbercept as a primary treatment for choroidal neovascularization secondary to punctate inner choroidopathy. ( 28606070 )
2017
19
Multiple Choroidal Ruptures in a Patient With Angioid Streaks. ( 28278344 )
2017
20
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. ( 28984344 )
2017
21
Choroidal thickness in traumatic optic neuropathy. ( 28937859 )
2017
22
Incidental choroid plexus papilloma in a child: A difficult decision. ( 28607820 )
2017
23
Detection of Silent Type I Choroidal Neovascular Membrane in Chronic Central Serous Chorioretinopathy Using En Face Swept-Source Optical Coherence Tomography Angiography. ( 29348931 )
2017
24
Choroid Plexitis and Ependymitis by Magnetic Resonance Imaging are Biomarkers of Neuronal Damage and Inflammation in HIV-negative Cryptococcal Meningoencephalitis. ( 28835663 )
2017
25
Choroid plexus papilloma. ( 28413558 )
2017
26
Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )
2017
27
Swept source optical coherence tomography-angiography of choroid in choroidal hemangioma before and after laser photocoagulation. ( 28820167 )
2017
28
Choroidal Thickness Variation According to Refractive Error Measured by Spectral Domain-optical Coherence Tomography in Korean Children. ( 28367044 )
2017
29
Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography. ( 28973324 )
2017
30
A choroid plexus cyst in the fourth ventricle of a Sprague-Dawley rat. ( 28798531 )
2017
31
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017
32
Assessment of peripapillary choroidal thickness in primary open-angle glaucoma patients with choroidal vascular prominence. ( 28929241 )
2017
33
Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations. ( 28192798 )
2017
34
Choroidal Imaging with Swept-Source Optical Coherence Tomography in Patients with Birdshot Chorioretinopathy: Choroidal Reflectivity and Thickness. ( 28456419 )
2017
35
The absence that makes the difference: choroidal abnormalities in Legius syndrome. ( 28747691 )
2017
36
Choroid Plexus Cyst in a Neonatal Burmeister's Porpoise (Phocoena spinipinnis). ( 28735671 )
2017
37
A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration. ( 28739342 )
2017
38
Gastric Adenocarcinoma with Systemic Metastasis Involving the Intraocular Choroid and Duodenum. ( 28835091 )
2017
39
Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? ( 28166316 )
2017
40
Choroidal hypoperfusion: an indicator of low tension neovascular glaucoma. ( 29256166 )
2017
41
Bilateral choroidal neovascularisation associated with adult-onset foveomacular vitelliform dystrophy. ( 27558081 )
2017
42
Sturge-Weber Syndrome Associated with Monolateral Ocular Melanocytosis, Iris Mammillations, and Diffuse Choroidal Haemangioma. ( 28868033 )
2017
43
Swept-source optical coherence tomography angiography in serpiginous choroiditis. ( 28982952 )
2017
44
Serpiginous Choroiditis. ( 28418567 )
2017
45
Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography. ( 27894511 )
2017
46
Bilateral Choroidal Occlusion in Antiphospholipid Syndrome Associated with Systemic Lupus Erythematosus. ( 29301604 )
2017
47
Multifocal Choroiditis with Peripheral Subretinal Fibrosis and Optic Nerve Involvement. ( 28734337 )
2017
48
Choroidal thickness measurements in children with isolated growth hormone deficiency. ( 28912516 )
2017
49
The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. ( 28852194 )
2017
50
Treatment of choice for patients with EGFR mutation-positive non-small cell lung carcinoma presenting with choroidal metastases: radiotherapy or TKIs? ( 28237165 )
2017

Variations for Choroiditis

Expression for Choroiditis

Search GEO for disease gene expression data for Choroiditis.

Pathways for Choroiditis

GO Terms for Choroiditis

Cellular components related to Choroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CFB CFH HTRA1 IL10 TNF
2 extracellular space GO:0005615 9.02 CFB CFH HTRA1 IL10 TNF

Biological processes related to Choroiditis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.49 IL10 TNF
2 negative regulation of mitotic cell cycle GO:0045930 9.48 IL10 TNF
3 positive regulation of cytokine secretion GO:0050715 9.46 IL10 TNF
4 negative regulation of interleukin-6 production GO:0032715 9.43 IL10 TNF
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 IL10 TNF
6 negative regulation of growth of symbiont in host GO:0044130 9.37 IL10 TNF
7 complement activation, alternative pathway GO:0006957 9.32 CFB CFH
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 IL10 TNF
9 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
10 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
11 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Sources for Choroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
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51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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