MCID: CHR008
MIFTS: 54

Choroiditis malady

Rare diseases, Eye diseases categories
Download this MalaCard

Summaries for Choroiditis

About this section


Fully expand this MalaCard
Wikipedia:65 }} Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and... more...

MalaCards based summary: Choroiditis is related to age related macular degeneration and uveitis. An important gene associated with Choroiditis is ARMS2 (age-related maculopathy susceptibility 2), and among its related pathways are Complement and coagulation cascades and Creation of C4 and C2 activators. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Choroiditis

About this section

Choroiditis, Aliases & Descriptions:

Name: Choroiditis 8 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:11406
SNOMED-CT57 16553002, 193449000
MeSH34 D002833

Related Diseases for Choroiditis

About this section

Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to choroiditis

Symptoms for Choroiditis

About this section

Drugs & Therapeutics for Choroiditis

About this section

Drug clinical trials:

Search ClinicalTrials for Choroiditis

Search NIH Clinical Center for Choroiditis

Genetic Tests for Choroiditis

About this section

Anatomical Context for Choroiditis

About this section

MalaCards organs/tissues related to Choroiditis:

32
Retina, Eye, Endothelial, Brain, Thyroid, Bone, Lung, Skin, Breast, Prostate, Testes, Pineal, Ovary, T cells, Bone marrow, Cortex, Smooth muscle, Kidney, B cells, Pituitary, Cerebellum, Spinal cord, Skeletal muscle, Colon, Liver, Salivary gland, Temporal lobe, Ciliary ganglion, Hypothalamus

Animal Models for Choroiditis or affiliated genes

About this section

MGI Mouse Phenotypes related to Choroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0IL10, HTRA1, TNF, CFH
2MP:00053917.9IL10, HTRA1, TNF, CFH
3MP:00053907.9CFB, TNF, HTRA1, IL10

Publications for Choroiditis

About this section

Articles related to Choroiditis:

(show top 50)    (show all 2230)
idTitleAuthorsYear
1
Authors' response: evaluation of choroidal thickness among patients with oculocutaneous albinism. (24876456)
2014
2
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
3
Choroidal neovascularization in Bardet-Biedl syndrome. (23565731)
2013
4
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
5
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
6
Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier. (23000117)
2012
7
A case of choroid plexus papilloma with stromal sclerosis and indistinct papillary structures. (21968641)
2012
8
Imaging in the diagnosis and management of serpiginous choroiditis. (22954945)
2012
9
Eales disease associated with serpiginous choroiditis. (23143459)
2012
10
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
11
The cytologic findings in choroid plexus carcinoma: report of a case with differential diagnosis. (22180231)
2012
12
Recurrent metastatic breast carcinoma presenting with pansinusitis and choroidal metastases and subsequent bilateral simultaneous orbital cellulitis. (22352825)
2012
13
Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. (21617757)
2011
14
Unilateral solitary choroidal granuloma as presenting sign of secondary syphilis. (21562892)
2011
15
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. (21442238)
2011
16
Juxtafoveal choroidal neovascularization secondary to persistent placoid maculopathy treated with intravitreal bevacizumab. (20666681)
2010
17
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
18
CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (20574013)
2010
19
Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa. (18627486)
2009
20
Choroidal neovascularization associated with goldmann-favre syndrome. (25390220)
2007
21
Molecular mechanism of choroidal neovascularization in age-related macular degeneration]. (18051818)
2007
22
Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. (16028003)
2005
23
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
24
Choroidal ganglion cells in prenatal, young, and middle-aged human donor eyes. (16109647)
2005
25
Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis. (15522374)
2004
26
Adenylyl and guanylyl cyclase activity in the choroid. (15051471)
2004
27
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies. (12700654)
2003
28
Choroid plexectomy reduces neurosurgical intervention in patients with hydranencephaly. (11919449)
2002
29
Choroid plexus papilloma in the posterior cranial fossa: MR, CT, and angiographic findings. (11679220)
2001
30
Cyclin-dependent kinase inhibitory protein expression in human choroidal melanoma tumors. (10967035)
2000
31
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
32
Regulation effect of vascular endothelial growth factor on human fetal choroid vascularization. (12579722)
2000
33
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
34
The correlation between cell surface markers and clinical features in choroidal malignant melanomas. (10624422)
1999
35
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
36
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
37
Laser photocoagulation of choroidal neovascularization in angioid streaks. (9051836)
1997
38
The choroid plexus epithelium is the site of the organic anion transport protein in the brain. (8990200)
1997
39
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
40
The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (9182293)
1996
41
Lectin histochemistry of choroidal malignant melanoma]. (8328344)
1993
42
Gyrate atrophy of the choroid and retina in a 5-year-old girl. (1789102)
1991
43
Gyrate atrophy of the choroid and retina. Early findings. (3991128)
1985
44
Schistosomotic choroiditis. II. Report of first case. (3994947)
1985
45
Osseous choristoma of the choroid simulating a choroidal melanoma. Association with a positive 32P test. (697626)
1978
46
Raised plasma-ornithine and gyrate atrophy of the choroid and retina. (4122112)
1973
47
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
48
Peters' anomaly and total posterior coloboma of retinal pigment epithelium and choroid. (4623873)
1972
49
Ochronosis; metastasis in the choroid in a case of mammary carcinoma; Hans-SchA1ller-Christian lipoidosis; arachnodactylia. (18939179)
1948
50
Case of Congenital Morbus Cordis associated with Coloboma of Iris and Choroid. (19982581)
1922

Variations for Choroiditis

About this section

Expression for genes affiliated with Choroiditis

About this section
Expression patterns in normal tissues for genes affiliated with Choroiditis

Search GEO for disease gene expression data for Choroiditis.

Pathways for genes affiliated with Choroiditis

About this section

Pathways related to Choroiditis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.4CFB, CFH
2
Show member pathways
9.4CFB, CFH
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.4CFB, CFH
49.1TNF, IL10
59.1IL10, TNF
6
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL10, TNF
7
Show member pathways
IL27-mediated signaling events37
9.1IL10, TNF
89.1TNF, IL10
9
Show member pathways
9.1IL10, TNF
109.1IL10, TNF
119.1TNF, IL10
129.1IL10, TNF
139.1IL10, TNF
148.6IL10, CFB, CFH

Compounds for genes affiliated with Choroiditis

About this section

Compounds related to Choroiditis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1cdp571449.6IL10, TNF
2interferon gamma449.6IL10, TNF
3blys449.6IL10, TNF
4gabexate mesilate449.6IL10, TNF
5ulinastatin449.6TNF, IL10
6toxin-1449.6TNF, IL10
7mip 1alpha449.6IL10, TNF
8natalizumab44 1110.5TNF, IL10
9il-12449.5IL10, TNF
105 aminosalicylic acid449.5IL10, TNF
11adalimumab44 50 1111.5TNF, IL10
12indoleamine449.5IL10, TNF
13imiquimod44 61 28 1112.5IL10, TNF
14cyclosporine50 1110.5TNF, IL10
15polymyxin b449.5IL10, TNF
16groalpha449.5TNF, IL10
17okt3449.5TNF, IL10
18gm-csf44 2810.5IL10, TNF
19lipoteichoic acid449.5IL10, TNF
208-isoprostane449.5TNF, IL10
21polyinosinic-polycytidylic acid449.5IL10, TNF
222,5-oligoadenylate449.5IL10, TNF
23rolipram44 61 2811.5IL10, TNF
24etanercept44 50 1111.5IL10, TNF
25il 10449.5TNF, IL10
26mycophenolate mofetil44 50 1111.5TNF, IL10
27tarc449.4TNF, IL10
28infliximab44 50 1111.4TNF, IL10
29peptidoglycan44 2810.4IL10, TNF
30ivig449.4IL10, TNF
31ccl344 2810.4TNF, IL10
32pentoxifylline44 1110.4TNF, IL10
33neopterin449.3IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2449.3TNF, IL10
35quinine44 28 2 50 1113.3IL10, CFH
36rituximab44 50 1111.3IL10, TNF
37chloroquine44 2 50 28 1113.2TNF, IL10
38thalidomide44 50 61 1112.2TNF, IL10
39hydrocortisone44 2 61 1112.1IL10, TNF
40atorvastatin44 50 28 24 1113.0TNF, IL10
41tacrolimus44 50 1110.9CFH, TNF, IL10
42cyclosporin a44 28 6110.9CFH, TNF, IL10
43prednisolone44 28 1110.8TNF, IL10
44serine448.6CFH, CFB, TNF, HTRA1
45dexamethasone44 50 28 1111.5IL10, TNF, CFH

GO Terms for genes affiliated with Choroiditis

About this section

Cellular components related to Choroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4CFB, CFH
2extracellular spaceGO:0056157.7IL10, HTRA1, TNF, CFH

Biological processes related to Choroiditis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:0069579.6CFH, CFB
2regulation of complement activationGO:0304499.5CFH, CFB
3receptor biosynthetic processGO:0328009.4IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
5negative regulation of growth of symbiont in hostGO:0441309.3IL10, TNF
6complement activationGO:0069569.3CFH, CFB
7negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
8positive regulation of cytokine secretionGO:0507159.2IL10, TNF
9response to activityGO:0148239.1IL10, TNF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
11response to glucocorticoidGO:0513848.8IL10, TNF

Products for genes affiliated with Choroiditis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Choroiditis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet