MCID: CHR008
MIFTS: 45

Choroiditis malady

Rare diseases category

Summaries for Choroiditis

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Wikipedia:63 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

MalaCards based summary: Choroiditis is related to uveitis and blindness. An important gene associated with Choroiditis is ARMS2 (age-related maculopathy susceptibility 2), and among its related pathways are Complement and coagulation cascades and Creation of C4 and C2 activators. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Choroiditis

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Choroiditis, Aliases & Descriptions:

Name: Choroiditis 9 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:11406
SNOMED-CT55 16553002, 193449000
MeSH33 D002833

Related Diseases for Choroiditis

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Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to choroiditis

Symptoms for Choroiditis

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Drugs & Therapeutics for Choroiditis

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Drug clinical trials:

Search ClinicalTrials for Choroiditis

Search NIH Clinical Center for Choroiditis

Genetic Tests for Choroiditis

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Anatomical Context for Choroiditis

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MalaCards organs/tissues related to Choroiditis:

31
Retina, Eye, Endothelial, Brain, Thyroid, Bone, Lung, Skin, Breast, Prostate, Testes, Pineal, Ovary, T cells, Bone marrow, Cortex, Smooth muscle, Kidney, B cells, Pituitary, Cerebellum, Spinal cord, Skeletal muscle, Colon, Liver, Salivary gland, Temporal lobe, Ciliary ganglion, Hypothalamus

Animal Models for Choroiditis or affiliated genes

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MGI Mouse Phenotypes related to Choroiditis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0IL10, HTRA1, TNF, CFH
2MP:00053917.9IL10, HTRA1, TNF, CFH
3MP:00053907.9CFB, TNF, HTRA1, IL10

Publications for Choroiditis

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Articles related to Choroiditis:

(show top 50)    (show all 2284)
idTitleAuthorsYear
1
Choroidal thickness in non-arteritic anterior ischemic optic neuropathy. (25488646)
2015
2
Goldmann-Witmer, definitive diagnosis in unifocal helicoid choroiditis. (25443192)
2014
3
Authors' response: evaluation of choroidal thickness among patients with oculocutaneous albinism. (24876456)
2014
4
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
5
Choroidal neovascularization in Bardet-Biedl syndrome. (23565731)
2013
6
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
7
Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier. (23000117)
2012
8
A case of choroid plexus papilloma with stromal sclerosis and indistinct papillary structures. (21968641)
2012
9
Imaging in the diagnosis and management of serpiginous choroiditis. (22954945)
2012
10
Eales disease associated with serpiginous choroiditis. (23143459)
2012
11
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
12
The cytologic findings in choroid plexus carcinoma: report of a case with differential diagnosis. (22180231)
2012
13
Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. (21617757)
2011
14
Unilateral solitary choroidal granuloma as presenting sign of secondary syphilis. (21562892)
2011
15
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. (21442238)
2011
16
Juxtafoveal choroidal neovascularization secondary to persistent placoid maculopathy treated with intravitreal bevacizumab. (20666681)
2010
17
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
18
CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (20574013)
2010
19
Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa. (18627486)
2009
20
Choroidal neovascularization associated with goldmann-favre syndrome. (25390220)
2007
21
Molecular mechanism of choroidal neovascularization in age-related macular degeneration]. (18051818)
2007
22
Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. (16028003)
2005
23
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
24
Choroidal ganglion cells in prenatal, young, and middle-aged human donor eyes. (16109647)
2005
25
Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis. (15522374)
2004
26
Adenylyl and guanylyl cyclase activity in the choroid. (15051471)
2004
27
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies. (12700654)
2003
28
Choroid plexectomy reduces neurosurgical intervention in patients with hydranencephaly. (11919449)
2002
29
Choroid plexus papilloma in the posterior cranial fossa: MR, CT, and angiographic findings. (11679220)
2001
30
Cyclin-dependent kinase inhibitory protein expression in human choroidal melanoma tumors. (10967035)
2000
31
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
32
Regulation effect of vascular endothelial growth factor on human fetal choroid vascularization. (12579722)
2000
33
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
34
The correlation between cell surface markers and clinical features in choroidal malignant melanomas. (10624422)
1999
35
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
36
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
37
Laser photocoagulation of choroidal neovascularization in angioid streaks. (9051836)
1997
38
The choroid plexus epithelium is the site of the organic anion transport protein in the brain. (8990200)
1997
39
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
40
The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (9182293)
1996
41
Lectin histochemistry of choroidal malignant melanoma]. (8328344)
1993
42
Gyrate atrophy of the choroid and retina in a 5-year-old girl. (1789102)
1991
43
Gyrate atrophy of the choroid and retina. Early findings. (3991128)
1985
44
Schistosomotic choroiditis. II. Report of first case. (3994947)
1985
45
Osseous choristoma of the choroid simulating a choroidal melanoma. Association with a positive 32P test. (697626)
1978
46
Raised plasma-ornithine and gyrate atrophy of the choroid and retina. (4122112)
1973
47
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
48
Peters' anomaly and total posterior coloboma of retinal pigment epithelium and choroid. (4623873)
1972
49
Ochronosis; metastasis in the choroid in a case of mammary carcinoma; Hans-SchA1ller-Christian lipoidosis; arachnodactylia. (18939179)
1948
50
Case of Congenital Morbus Cordis associated with Coloboma of Iris and Choroid. (19982581)
1922

Variations for Choroiditis

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Expression for genes affiliated with Choroiditis

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Search GEO for disease gene expression data for Choroiditis.

Pathways for genes affiliated with Choroiditis

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Pathways related to Choroiditis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.4CFB, CFH
2
Show member pathways
9.4CFB, CFH
3
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.4CFB, CFH
49.1TNF, IL10
59.1IL10, TNF
6
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.1IL10, TNF
7
Show member pathways
IL27-mediated signaling events36
9.1IL10, TNF
89.1TNF, IL10
9
Show member pathways
9.1IL10, TNF
109.1IL10, TNF
119.1TNF, IL10
129.1IL10, TNF
139.1IL10, TNF
148.6IL10, CFB, CFH

Compounds for genes affiliated with Choroiditis

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Compounds related to Choroiditis according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1cdp571439.6IL10, TNF
2interferon gamma439.6IL10, TNF
3blys439.6IL10, TNF
4gabexate mesilate439.6IL10, TNF
5ulinastatin439.6TNF, IL10
6toxin-1439.6TNF, IL10
7mip 1alpha439.6IL10, TNF
8natalizumab43 1210.5TNF, IL10
9il-12439.5IL10, TNF
105 aminosalicylic acid439.5IL10, TNF
11adalimumab43 49 1211.5TNF, IL10
12indoleamine439.5IL10, TNF
13imiquimod43 59 28 1212.5IL10, TNF
14cyclosporine49 1210.5TNF, IL10
15polymyxin b439.5IL10, TNF
16groalpha439.5TNF, IL10
17okt3439.5TNF, IL10
18gm-csf43 2810.5IL10, TNF
19lipoteichoic acid439.5IL10, TNF
208-isoprostane439.5TNF, IL10
21polyinosinic-polycytidylic acid439.5IL10, TNF
222,5-oligoadenylate439.5IL10, TNF
23rolipram43 59 2811.5IL10, TNF
24etanercept43 49 1211.5IL10, TNF
25il 10439.5TNF, IL10
26mycophenolate mofetil43 49 1211.5TNF, IL10
27tarc439.4TNF, IL10
28infliximab43 49 1211.4TNF, IL10
29peptidoglycan43 2810.4IL10, TNF
30ivig439.4IL10, TNF
31ccl343 2810.4TNF, IL10
32pentoxifylline43 1210.4TNF, IL10
33neopterin439.3IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2439.3TNF, IL10
35quinine43 28 2 49 1213.3IL10, CFH
36rituximab43 49 1211.3IL10, TNF
37chloroquine43 2 49 28 1213.2TNF, IL10
38thalidomide43 49 59 1212.2TNF, IL10
39hydrocortisone43 2 59 1212.1IL10, TNF
40atorvastatin43 49 28 24 1213.0TNF, IL10
41tacrolimus43 49 1210.9CFH, TNF, IL10
42cyclosporin a43 28 5910.9CFH, TNF, IL10
43prednisolone43 28 1210.8TNF, IL10
44serine438.6CFH, CFB, TNF, HTRA1
45dexamethasone43 49 28 1211.5IL10, TNF, CFH

GO Terms for genes affiliated with Choroiditis

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Cellular components related to Choroiditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.4CFB, CFH
2extracellular spaceGO:00056157.7IL10, HTRA1, TNF, CFH

Biological processes related to Choroiditis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00069579.6CFH, CFB
2regulation of complement activationGO:00304499.5CFH, CFB
3receptor biosynthetic processGO:00328009.4IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.4IL10, TNF
5negative regulation of growth of symbiont in hostGO:00441309.3IL10, TNF
6complement activationGO:00069569.3CFH, CFB
7negative regulation of interleukin-6 productionGO:00327159.3IL10, TNF
8positive regulation of cytokine secretionGO:00507159.2IL10, TNF
9response to activityGO:00148239.1IL10, TNF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1IL10, TNF
11response to glucocorticoidGO:00513848.8IL10, TNF

Products for genes affiliated with Choroiditis

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Sources for Choroiditis

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3CDC
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25ICD10
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29KEGG
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56SNOMED-CT via Orphanet
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