MCID: CHR008
MIFTS: 57

Choroiditis malady

Summaries for Choroiditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

MalaCards: Choroiditis, also known as choroiditis nos, is related to choroid plexus papilloma and papilloma. An important gene associated with Choroiditis is SLC46A1 (solute carrier family 46 (folate transporter), member 1), and among its related pathways is the visual cycle I (vertebrates). The compounds cysteine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are homeostasis/metabolism and vision/eye.

Aliases & Classifications for Choroiditis

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

choroiditis 8 42 60
choroiditis nos 8


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Disease Ontology8 DOID:11406
SNOMED-CT56 193449000, 16553002
MeSH34 D002833

Related Diseases for Choroiditis

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17GeneCards, 18GeneDecks
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Diseases related to Choroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 548)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma31.4S100B, CT49, SYP, IGF2, MUC1, TTR
2papilloma31.4CT49
3choroid plexus carcinoma31.1SMARCB1
4melanoma31.1TIMP3, S100B, CT49
5age related macular degeneration31.0TIMP3, CFH
6glaucoma30.5TTR
7vitelliform macular dystrophy30.3TIMP3, PRPH2
8retinal degeneration30.3TIMP3, PRPH2, CHM, ABCA4, GFAP, OAT
9retinal disease30.3TIMP3, PRPH2, CHM, ABCA4, GFAP
10adenocarcinoma30.3TIMP3, CT49, SYP, MUC1
11meningioma30.3S100B, CT49, SYP, IGF2, MUC1, GFAP
12partial central choroid dystrophy30.3TIMP3, PRPH2
13hepatitis30.1TTR
14adenoma29.9TIMP3, CT49, SYP, IGF2, MUC1
15retinoblastoma29.9SMARCB1, GFAP, SYP, CT49
16ganglioneuroma29.9S100B, SYP, GFAP
17atypical teratoid rhabdoid tumor29.9SMARCB1
18papillary ependymoma29.8GFAP, SYP, S100B
19paraganglioma29.8S100B, SYP, GFAP
20primary open angle glaucoma29.8ABCA4
21parkinson's disease29.8CHM
22neurilemmoma29.8SMARCB1, GFAP
23medulloblastoma29.6TIMP3, S100B, CT49, SYP, IGF2, GFAP
24glioblastoma multiforme29.5SMARCB1, GFAP, CT49, S100B, TIMP3
25leiomyosarcoma29.5S100B, IGF2, MUC1, SMARCB1
26hemangioblastoma29.5S100B, SYP, MUC1, GFAP
27sarcoma29.5S100B, IGF2, MUC1, SMARCB1
28brain cancer29.5CT49, SYP, GFAP, SMARCB1
29hemangiopericytoma29.5S100B, IGF2, MUC1
30ganglioglioma29.5GFAP, SYP, S100B
31eye disease29.5OAT, ABCA4, CHM
32rhabdomyosarcoma29.5SMARCB1, IGF2, S100B
33cone-rod dystrophy 229.5ABCA4, PRPH2, TIMP3
34neurofibroma29.5MUC1, SYP, S100B
35chondrosarcoma29.5S100B, MUC1
36leiomyoma29.5IGF2, S100B
37olfactory neuroblastoma29.5S100B, SYP
38giant cell glioblastoma29.5GFAP
39clear cell sarcoma29.5IGF2, S100B
40primary hyperoxaluria29.5CFH, TTR, CT49, TIMP3
41proliferative diabetic retinopathy29.5TIMP3, GFAP
42fibrosarcoma29.5TIMP3
43retinitis10.8
44gyrate atrophy10.8
45choroid disease10.7
46angioid streaks10.6
47coloboma10.6
48retinal detachment10.5
49myopia10.5
50angioid streaks of choroid10.5

Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to choroiditis

Clinical Features for Choroiditis

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Drugs & Therapeutics for Choroiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choroiditis

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Anatomical Context for Choroiditis

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32MalaCards
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MalaCards organs/tissues related to Choroiditis:

32
Retina, Eye, Endothelial, Brain, Thyroid, Bone, Skin, Lung, Breast, Testes, Prostate, Ovary, Pineal, T cells, B cells, Pituitary, Bone marrow, Cortex, Smooth muscle, Hypothalamus, Ciliary ganglion, Temporal lobe, Cerebellum, Spinal cord, Skeletal muscle, Colon, Kidney, Liver, Salivary gland

Animal Models for Choroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Choroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.6MUC1, IGF2, CHM, HTR2C, TIMP3, ABCA4
2MP:000539112.3OAT, TIMP3, OPTC, PRPH2, CHM, IGF2
3MP:000363112.1PRPH2, SYP, CHM, IGF2, ABCA4, GFAP
4MP:000538511.6TIMP3, OPTC, PRPH2, CHM, IGF2, ABCA4
5MP:000118611.4TIMP3, HTR2C, PRPH2, CHM, ABCA4, OAT

Publications for Choroiditis

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50PubMed
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Articles related to Choroiditis:

(show top 50)    (show all 2143)
idTitleAuthorsYear
1
There is no relation between the occurrence of proliferative vitreoretinopathy and the location of the donor site after transplantation of a free autologous retinal pigment epithelium-choroid graft. (23890210)
2013
2
Bilateral choroidal detachment following cataract surgery in a 40-day-old infant. (23871135)
2013
3
Endovascular embolization of a giant aneurysm in medial posterior choroidal artery with associated arteriovenous malformation. (23793438)
2013
4
Intravitreal bevacizumab for extrafoveal choroidal neovascularization secondary to pathologic myopia. (23190919)
2013
5
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
6
Polymorphisms in the VEGF-A in polypoidal choroidal vasculopathy in a Korean population. (22307775)
2012
7
Ultrasonographic findings in circumscribed choroidal hemangioma after photodynamic therapy. (23437452)
2012
8
A clinicopathological study of the significance of the proportion of choroid morphology in chordoid meningioma. (22516546)
2012
9
Fetal tumors of the choroid plexus: is differential diagnosis between papilloma and carcinoma possible? (21800389)
2011
10
Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine, which may be associated with development of choroidal neovascularization. (21527754)
2011
11
Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy. (20229103)
2010
12
Endoscopic choroid plexus cauterization versus ventriculoperitoneal shunt for hydranencephaly and near hydranencephaly: a prospective study. (20173541)
2010
13
Choroid plexus carcinoma: report of two cases. (19679976)
2009
14
Central retinal vein occlusion with cilioretinal infarction from branch flow exclusion and choroidal arterial steal. (19898176)
2009
15
Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. (17389522)
2007
16
Ahmed glaucoma valve implant for childhood glaucoma in Sturge-Weber syndrome with choroidal hemangioma. (17214399)
2006
17
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. (16970777)
2006
18
Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. (16330944)
2006
19
Photodynamic therapy for subfoveal choroidal neovascularisation in Vogt-Koyanagi-Harada disease. (16687455)
2006
20
Sturge-Weber syndrome (choroidal hemangioma and glaucoma). (16250225)
2005
21
Serpiginous choroiditis by any other name. (16286635)
2005
22
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies. (12700654)
2003
23
Expression of the c-kit receptor in choroidal melanomas. (12690299)
2003
24
Subretinal fibrosis and linear streaks in multifocal choroiditis. (11146744)
2001
25
Disseminating histologically benign multiple papilloma of the choroid plexus: case report. (11770132)
2001
26
Lateral ventricle choroid plexus papilloma in childhood: management and complications. (11165613)
2000
27
Diffuse and circumscribed choroidal hemangiomas in a patient with Sturge-Weber syndrome. (10088826)
1999
28
Clear cell differentiation in choroidal melanoma. COMS report no. 8. Collaborative Ocular Melanoma Study Group. (9230830)
1997
29
Multidrug resistance-related proteins in primary choroidal melanomas and in vitro cell lines. (9375571)
1997
30
Prenatal detection of the separation of the great toe, toe syndactyly, and large bilateral choroid plexus cysts in a fetus with trisomy 18. (8724719)
1996
31
Tuberculous choroiditis and acquired immunodeficiency syndrome. (8010705)
1994
32
Choroidal neovascularization in a patient with adult foveomacular dystrophy and a mutation in the retinal degeneration slow gene (Pro 210 Arg). (7519821)
1994
33
Gyrate atrophy of the choroid and retina in a 5-year-old girl. (1789102)
1991
34
Pneumocystis carinii choroiditis after long-term aerosolized pentamidine therapy. (2378374)
1990
35
Primary choroid plexus papilloma of the cerebellopontine angle: MR imaging. (2352637)
1990
36
Neuroradiology case of the day. Choroid plexus papilloma, third ventricle. (2718873)
1989
37
Choroid plexus carcinoma in a dog. (2723160)
1989
38
Choroid plexus papilloma in early infants. (2642234)
1989
39
An immunohistochemical study of cytokeratin and glial fibrillary acidic protein in choroid plexus papilloma. (2450443)
1988
40
Schistosomotic choroiditis. II. Report of first case. (3994947)
1985
41
Ultrasound in the diagnosis of choroid plexus papilloma. (3920266)
1985
42
Pseudocystic destruction of the temporal bone caused by choroid plexus papilloma. (6740004)
1984
43
Gyrate atrophy of the choroid and retina with hyperornithinemia. Deficient formation of guanidinoacetic acid from arginine. (7419715)
1980
44
Uveal melanoma presenting as post-traumatic choroidal hemorrhage and panophthalmitis. (890595)
1977
45
Gyrate atrophy of the choroid and retina with hyperornithinemia. (1200098)
1975
46
Partial xenon coagulation of net in histoplasmic choroiditis. (1147495)
1975
47
X-linked choroidal sclerosis. A stage of choroideremia. (4827609)
1974
48
Choroid plexus papilloma mimicking degenerative brain disease in childhood. (5060466)
1972
49
PRESUMED HISTOPLASMIC CHOROIDITIS. A CLINICAL ANALYSIS OF 43 CASES. (14106885)
1964
50
Metastatic Choroiditis from Focal Infection. (16692639)
1923

Genetic Variations for Choroiditis

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Expression for genes affiliated with Choroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroiditis

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Pathways for genes affiliated with Choroiditis

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Choroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.8TTR, ABCA4

Compounds for genes affiliated with Choroiditis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Choroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1cysteine4412.9CFH, TIMP3, S100B, HTR2C, CT49, OPTC
2retinoic acid44 2413.4TIMP3, S100B, CT49, SYP, IGF2, MUC1
3serine4412.3S100B, HTR2C, CT49, SYP, IGF2, MUC1
4paraffin4412.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
5testosterone44 59 11 2415.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
6dexamethasone44 49 28 1115.2TIMP3, S100B, SYP, IGF2, MUC1, TTR
7glutamate4412.2TIMP3, S100B, HTR2C, SYP, IGF2, TTR
8estrogen4412.2TIMP3, S100B, CT49, SYP, IGF2, MUC1
9lipid4412.2TIMP3, S100B, HTR2C, SYP, CHM, MUC1
10tyrosine4412.1TIMP3, S100B, HTR2C, SYP, IGF2, MUC1
11glutamine4412.1TIMP3, S100B, SYP, IGF2, TTR, GFAP
12progesterone44 59 28 11 2416.0TIMP3, S100B, CT49, SYP, IGF2, MUC1
13vegf4412.0TIMP3, S100B, CT49, SYP, IGF2, MUC1
14glucose4412.0TIMP3, S100B, IGF2, MUC1, TTR, GFAP
15estradiol44 11 2413.9TIMP3, CT49, SYP, IGF2, MUC1, GFAP
16creatinine4411.8S100B, SYP, IGF2, MUC1, TTR, GFAP
17cholesterol44 28 11 2414.8SYP, MUC1, ABCA4, TTR, GFAP, CFH
18arginine4411.8TIMP3, S100B, IGF2, TTR, GFAP, OAT
19zinc44 2412.8S100B, CT49, IGF2, TTR, GFAP, CFH
20alanine4411.7S100B, CT49, IGF2, TTR, GFAP, CFH
21dbc-amp4411.7TIMP3, S100B, SYP, IGF2, GFAP
22acth4411.7GFAP, MUC1, IGF2, SYP, S100B
23agar4411.7GFAP, TTR, MUC1, IGF2, CT49
24gaba4411.7S100B, HTR2C, SYP, GFAP, OAT
25norepinephrine44 11 2413.7S100B, HTR2C, SYP, IGF2, TTR
26glycogen44 2412.6S100B, SYP, IGF2, MUC1, GFAP
27dopamine44 28 11 2414.6S100B, HTR2C, SYP, TTR, GFAP
28cisplatin44 49 59 1114.6SYP, IGF2, MUC1, GFAP, CFH
29thymidine44 2412.6S100B, CT49, IGF2, MUC1, GFAP
30s 1004411.6S100B, SYP, MUC1, GFAP
31reticulin4411.6S100B, SYP, MUC1, GFAP
32aspartate4411.6S100B, PRPH2, TTR, GFAP, OAT
33hematoxylin4411.5S100B, SYP, MUC1, GFAP
34adenylate4411.5S100B, HTR2C, IGF2, TTR, GFAP
35formaldehyde44 2412.5S100B, SYP, MUC1, GFAP
36eosin4411.4S100B, MUC1, GFAP
37mucicarmine4411.4S100B, SYP, MUC1
38b 7234411.3S100B, SYP, MUC1
39methionine4411.3TIMP3, S100B, TTR, GFAP
40forskolin44 49 1113.2GFAP, CT49
41guanidine hydrochloride4411.2TTR, MUC1, IGF2
42ethanol44 49 11 2414.2S100B, SYP, MUC1, GFAP
43lithium44 49 11 2414.2MUC1, SYP, HTR2C
44silver4411.1CT49, SYP, GFAP
45phospholipid4411.1ABCA4, MUC1, SYP, S100B
46polyethylene glycol4411.1GFAP, MUC1, IGF2
47n-acetylaspartate4411.1GFAP, SYP
48acetylcholine44 49 28 11 2415.0S100B, HTR2C, SYP, GFAP
49glycosaminoglycan4411.0CFH, IGF2, TIMP3
502,3-cyclic nucleotide4410.5GFAP, S100B

GO Terms for genes affiliated with Choroiditis

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16Gene Ontology
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Biological processes related to Choroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.0OAT, ABCA4, CHM, PRPH2, TIMP3
2cellular response to organic substanceGO:07131010.8SYP, TIMP3

Products for genes affiliated with Choroiditis

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Sources for Choroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet