MCID: CHR008
MIFTS: 55

Choroiditis malady

Rare diseases, Eye diseases categories

Summaries for Choroiditis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

MalaCards: Choroiditis, also known as choroiditis nos, is related to age related macular degeneration and uveitis. An important gene associated with Choroiditis is ARMS2 (age-related maculopathy susceptibility 2), and among its related pathways are Complement and coagulation cascades and Creation of C4 and C2 activators. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Aliases & Classifications for Choroiditis

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9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

choroiditis 9 44 63
choroiditis nos 9


External Ids:

Disease Ontology9 DOID:11406
SNOMED-CT59 16553002, 193449000
MeSH36 D002833

Related Diseases for Choroiditis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Choroiditis:



Diseases related to choroiditis

Symptoms for Choroiditis

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Drugs & Therapeutics for Choroiditis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Choroiditis

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Anatomical Context for Choroiditis

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34MalaCards
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MalaCards organs/tissues related to Choroiditis:

34
Retina, Eye, Endothelial, Brain, Bone, Skin, Thyroid, Lung, Breast, Testes, Prostate, Ovary, Pineal, T cells, B cells, Pituitary, Bone marrow, Cortex, Hypothalamus, Ciliary ganglion, Temporal lobe, Cerebellum, Spinal cord, Smooth muscle, Skeletal muscle, Colon, Kidney, Liver, Salivary gland

Animal Models for Choroiditis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Choroiditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0IL10, HTRA1, TNF, CFH
2MP:00053917.9IL10, HTRA1, TNF, CFH
3MP:00053907.9CFB, TNF, HTRA1, IL10

Publications for Choroiditis

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53PubMed
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Articles related to Choroiditis:

(show top 50)    (show all 2126)
idTitleAuthorsYear
1
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
2
Choroidal neovascularization in Bardet-Biedl syndrome. (23565731)
2013
3
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
4
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
5
Peripapillary choroidal thickness in both eyes of glaucoma patients with unilateral visual field loss. (24011520)
2013
6
Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier. (23000117)
2012
7
A case of choroid plexus papilloma with stromal sclerosis and indistinct papillary structures. (21968641)
2012
8
Imaging in the diagnosis and management of serpiginous choroiditis. (22954945)
2012
9
Eales disease associated with serpiginous choroiditis. (23143459)
2012
10
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
11
The cytologic findings in choroid plexus carcinoma: report of a case with differential diagnosis. (22180231)
2012
12
Recurrent metastatic breast carcinoma presenting with pansinusitis and choroidal metastases and subsequent bilateral simultaneous orbital cellulitis. (22352825)
2012
13
Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. (21617757)
2011
14
Unilateral solitary choroidal granuloma as presenting sign of secondary syphilis. (21562892)
2011
15
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. (21442238)
2011
16
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
17
Juxtafoveal choroidal neovascularization secondary to persistent placoid maculopathy treated with intravitreal bevacizumab. (20666681)
2010
18
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
19
CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (20574013)
2010
20
Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa. (18627486)
2009
21
Molecular mechanism of choroidal neovascularization in age-related macular degeneration]. (18051818)
2007
22
Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. (16028003)
2005
23
Choroidal ganglion cells in prenatal, young, and middle-aged human donor eyes. (16109647)
2005
24
Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis. (15522374)
2004
25
Adenylyl and guanylyl cyclase activity in the choroid. (15051471)
2004
26
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies. (12700654)
2003
27
Choroid plexectomy reduces neurosurgical intervention in patients with hydranencephaly. (11919449)
2002
28
Choroid plexus papilloma in the posterior cranial fossa: MR, CT, and angiographic findings. (11679220)
2001
29
Cyclin-dependent kinase inhibitory protein expression in human choroidal melanoma tumors. (10967035)
2000
30
Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. (10768341)
2000
31
Regulation effect of vascular endothelial growth factor on human fetal choroid vascularization. (12579722)
2000
32
Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. (10533729)
1999
33
The correlation between cell surface markers and clinical features in choroidal malignant melanomas. (10624422)
1999
34
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
35
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
36
Laser photocoagulation of choroidal neovascularization in angioid streaks. (9051836)
1997
37
The choroid plexus epithelium is the site of the organic anion transport protein in the brain. (8990200)
1997
38
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
39
The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (9182293)
1996
40
Lectin histochemistry of choroidal malignant melanoma]. (8328344)
1993
41
Identification of an S-antigen-like molecule in human choroid plexus and cerebrospinal fluid. (1289136)
1992
42
Gyrate atrophy of the choroid and retina in a 5-year-old girl. (1789102)
1991
43
Gyrate atrophy of the choroid and retina. Early findings. (3991128)
1985
44
Schistosomotic choroiditis. II. Report of first case. (3994947)
1985
45
Osseous choristoma of the choroid simulating a choroidal melanoma. Association with a positive 32P test. (697626)
1978
46
Raised plasma-ornithine and gyrate atrophy of the choroid and retina. (4122112)
1973
47
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
48
Peters' anomaly and total posterior coloboma of retinal pigment epithelium and choroid. (4623873)
1972
49
Ochronosis; metastasis in the choroid in a case of mammary carcinoma; Hans-SchA1ller-Christian lipoidosis; arachnodactylia. (18939179)
1948
50
Case of Congenital Morbus Cordis associated with Coloboma of Iris and Choroid. (19982581)
1922

Variations for Choroiditis

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Expression for genes affiliated with Choroiditis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Choroiditis

Search GEO for disease gene expression data for Choroiditis.

Pathways for genes affiliated with Choroiditis

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 61Thomson Reuters, 58SinoBiological, 55R&D Systems
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Pathways related to Choroiditis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.4CFB, CFH
2
Show member pathways
9.4CFB, CFH
3
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.4CFB, CFH
49.1TNF, IL10
59.1IL10, TNF
6
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1IL10, TNF
7
Show member pathways
IL27-mediated signaling events39
9.1IL10, TNF
89.1TNF, IL10
9
Show member pathways
9.1IL10, TNF
109.1IL10, TNF
119.1TNF, IL10
129.1IL10, TNF
139.1IL10, TNF
148.6IL10, CFB, CFH

Compounds for genes affiliated with Choroiditis

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46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Choroiditis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1cdp571469.6IL10, TNF
2interferon gamma469.6IL10, TNF
3blys469.6IL10, TNF
4gabexate mesilate469.6IL10, TNF
5ulinastatin469.6TNF, IL10
6toxin-1469.6TNF, IL10
7mip 1alpha469.6IL10, TNF
8natalizumab46 1210.5TNF, IL10
9il-12469.5IL10, TNF
105 aminosalicylic acid469.5IL10, TNF
11adalimumab46 52 1211.5TNF, IL10
12indoleamine469.5IL10, TNF
13imiquimod46 62 30 1212.5IL10, TNF
14cyclosporine52 1210.5TNF, IL10
15polymyxin b469.5IL10, TNF
16groalpha469.5TNF, IL10
17okt3469.5TNF, IL10
18gm-csf46 3010.5IL10, TNF
19lipoteichoic acid469.5IL10, TNF
208-isoprostane469.5TNF, IL10
21polyinosinic-polycytidylic acid469.5IL10, TNF
222,5-oligoadenylate469.5IL10, TNF
23rolipram46 62 3011.5IL10, TNF
24etanercept46 52 1211.5IL10, TNF
25il 10469.5TNF, IL10
26mycophenolate mofetil46 52 1211.5TNF, IL10
27tarc469.4TNF, IL10
28infliximab46 52 1211.4TNF, IL10
29peptidoglycan46 3010.4IL10, TNF
30ivig469.4IL10, TNF
31ccl346 3010.4TNF, IL10
32pentoxifylline46 1210.4TNF, IL10
33neopterin469.3IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2469.3TNF, IL10
35quinine46 30 3 52 1213.3IL10, CFH
36rituximab46 52 1211.3IL10, TNF
37chloroquine46 3 52 30 1213.2TNF, IL10
38thalidomide46 52 62 1212.2TNF, IL10
39hydrocortisone46 3 62 1212.1IL10, TNF
40atorvastatin46 52 30 25 1213.0TNF, IL10
41tacrolimus46 52 1210.9CFH, TNF, IL10
42cyclosporin a46 30 6210.9CFH, TNF, IL10
43prednisolone46 30 1210.8TNF, IL10
44serine468.6CFH, CFB, TNF, HTRA1
45dexamethasone46 52 30 1211.5IL10, TNF, CFH

GO Terms for genes affiliated with Choroiditis

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17Gene Ontology
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Cellular components related to Choroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4CFB, CFH
2extracellular spaceGO:0056157.7IL10, HTRA1, TNF, CFH

Biological processes related to Choroiditis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:0069579.6CFH, CFB
2regulation of complement activationGO:0304499.5CFH, CFB
3receptor biosynthetic processGO:0328009.4IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
5negative regulation of growth of symbiont in hostGO:0441309.3IL10, TNF
6complement activationGO:0069569.3CFH, CFB
7negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
8positive regulation of cytokine secretionGO:0507159.2IL10, TNF
9response to activityGO:0148239.1IL10, TNF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
11response to glucocorticoidGO:0513848.8IL10, TNF

Products for genes affiliated with Choroiditis

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Sources for Choroiditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet