MCID: CHR034
MIFTS: 40

Chromophobe Adenoma malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Chromophobe Adenoma

Aliases & Descriptions for Chromophobe Adenoma:

Name: Chromophobe Adenoma 12 14
Adenoma, Chromophobe 42 69
Chromophobe Adenoma of the Pituitary Gland 12
Adenoma Chromophobe 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3828
MeSH 42 D000238
NCIt 47 C2857
SNOMED-CT 64 37039006
UMLS 69 C0001432

Summaries for Chromophobe Adenoma

MalaCards based summary : Chromophobe Adenoma, also known as adenoma, chromophobe, is related to adenoma and grin2a-related speech disorders and epilepsy. An important gene associated with Chromophobe Adenoma is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and TGF-Beta Pathway. The drugs Hormones and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Chromophobe Adenoma

Diseases related to Chromophobe Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 adenoma 10.7
2 grin2a-related speech disorders and epilepsy 10.3 GH1 PRL
3 cerebral hemisphere lipoma 10.3 GH1 PRL
4 gershoni-baruch syndrome 10.3 PRL TRH
5 macrocephaly, benign familial 10.3 GH1 POMC
6 caudal regression syndrome 10.3 GH1 POMC PRL
7 macular retinal edema 10.3 AVP POMC
8 african histoplasmosis 10.3 GNRH1 POMC PRL
9 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.3 GH1 POMC PRL
10 bagassosis 10.3 AVP POMC
11 extragonadal nonseminomatous germ cell tumor 10.3 GNRH1 POMC PRL
12 rheumatic encephalitis 10.3 GH1 POMC PRL
13 endometriosis 10.2 GNRH1 PRL PRLR
14 diverticulitis 10.2 GNRH1 PRL
15 glossopharyngeal nerve neoplasm 10.2 AVP POMC
16 hyperlipoproteinemia type iii 10.2 INS POMC
17 glaucoma, hereditary adult type 1a 10.2 GH1 GHRH PRL
18 critical congenital heart disease 10.2 GH1 GNRH1
19 congenital tricuspid stenosis 10.2 GH1 POMC PRL TRH
20 seow najjar syndrome 10.2 AVP INS
21 pulmonary neuroendocrine tumor 10.2 GH1 POMC PRL TRH
22 adult i blood group with or without congenital cataract 10.2 GH1 POMC PRL TRH
23 dacryoadenitis 10.2 INS POMC PRL
24 cold-induced sweating syndrome 2 10.2 GH1 POMC PRL TRH
25 childhood kidney cell carcinoma 10.2 AVP POMC
26 merkel cell carcinoma 10.2 INS POMC PRL
27 endometrial mixed adenocarcinoma 10.2 POMC TRH
28 mucopolysaccharidosis type vi 10.2 AVP GH1 POMC PRL
29 acute gonococcal salpingitis 10.2 GNRH1 POMC PRL TRH
30 adams-oliver syndrome 6 10.2 GH1 GNRH1 INS
31 kindler syndrome 10.2 AVP GNRH1 POMC PRL
32 epidural spinal canal meningioma 10.2 GNRH1 INS PRL
33 hypoglycemic coma 10.2 GNRH1 INS TRH
34 immune system organ benign neoplasm 10.1 GHRH POMC PRL TRH
35 chondroma 10.1 AVP INS POMC
36 hypothyroidism, congenital, nongoitrous, 1 10.1 INS SERPINA7 TRH
37 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.1 GH1 GHRH POMC PRL
38 pinguecula 10.1 GNRH1 INS PRL
39 vertebral artery occlusion 10.1 GNRH1 INS POMC PRL
40 pharynx cancer 10.1 AVP POMC TP53
41 sphingolipidosis 10.1 GNRH1 INS POMC PRL
42 pelvic muscle wasting 10.1 GNRH1 INS POMC PRL
43 necrobiosis lipoidica 10.1 PRL PRLR TP53
44 sternum lymphoma 10.1 AVP POMC TP53
45 neurogenic arthropathy 10.1 GHRH INS POMC
46 fatty liver disease 10.1 AVP INS POMC PRL
47 spondylolysis 10.1 GNRH1 INS POMC PRL
48 papillary craniopharyngioma 10.1 GNRH1 INS PRL TRH
49 avoidant personality disorder 10.1 GNRH1 INS POMC PRL
50 hyperthyroidism 10.1

Graphical network of the top 20 diseases related to Chromophobe Adenoma:



Diseases related to Chromophobe Adenoma

Symptoms & Phenotypes for Chromophobe Adenoma

MGI Mouse Phenotypes related to Chromophobe Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 GHRH GNRH1 INS ITGA2 POMC PRL
2 homeostasis/metabolism MP:0005376 10 AVP FLCN GHRH GNRH1 INS ITGA2
3 liver/biliary system MP:0005370 9.7 GHRH GNRH1 INS POMC PRL TET2
4 neoplasm MP:0002006 9.5 FLCN GNRH1 POMC PRL PRLR TET2
5 renal/urinary system MP:0005367 9.17 POMC TET2 TP53 AVP FLCN GNRH1

Drugs & Therapeutics for Chromophobe Adenoma

Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Dexamethasone acetate Phase 1 1177-87-3
4 glucocorticoids Phase 1
5
protease inhibitors Phase 1
6 Gastrointestinal Agents Phase 1
7 HIV Protease Inhibitors Phase 1
8 Hormone Antagonists Phase 1
9 Dexamethasone 21-phosphate Phase 1
10 Peripheral Nervous System Agents Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
12 Antiemetics Phase 1
13 Anti-Inflammatory Agents Phase 1
14 BB 1101 Phase 1
15 Autonomic Agents Phase 1
16 Antineoplastic Agents, Hormonal Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2
2 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1

Search NIH Clinical Center for Chromophobe Adenoma

Cochrane evidence based reviews: adenoma, chromophobe

Genetic Tests for Chromophobe Adenoma

Anatomical Context for Chromophobe Adenoma

MalaCards organs/tissues related to Chromophobe Adenoma:

39
Pituitary, Thyroid, Testes, Skin, Ovary

Publications for Chromophobe Adenoma

Articles related to Chromophobe Adenoma:

(show top 50) (show all 95)
id Title Authors Year
1
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. ( 19262038 )
2009
2
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? ( 9389566 )
1997
3
Non-functional pituitary chromophobe adenoma in a calf. ( 8878755 )
1996
4
Selective osmoreceptor dysfunction presenting as intermittent hypernatremia following surgery for a pituitary chromophobe adenoma. ( 3728518 )
1986
5
Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. ( 2985300 )
1985
6
Squamous metaplasia following necrosis of the adenohypophysis and of a chromophobe adenoma of the pituitary. ( 7080436 )
1982
7
Collection of gas within a huge chromophobe adenoma. A case report. ( 7121823 )
1982
8
Spontaneous hemorrhagic necrosis of chromophobe adenoma with clinical presentations simulating rupture of aneurysm. ( 7077217 )
1982
9
Hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor. ( 7103637 )
1982
10
Chromophobe adenoma of the pituitary with Cushing's syndrome and skin pigmentation. ( 514937 )
1979
11
Multiple myeloma masquerading as chromophobe adenoma. ( 445346 )
1979
12
Cytoplasmic filamentous masses in chromophobe adenoma of the human pituitary gland. ( 722396 )
1978
13
Malignant pituitary chromophobe adenoma in an infant accompanying diabetes insipidus. ( 735828 )
1978
14
Ultrastructure of capillaries in chromophobe adenoma. ( 714208 )
1978
15
Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age. ( 675127 )
1978
16
An autopsy case of pituitary chromophobe adenoma. ( 614080 )
1977
17
Case report. Tandem lesions: chromophobe adenoma and meningioma. ( 615235 )
1977
18
Galactorrhea in a 12-year-old boy with a chromophobe adenoma. ( 558298 )
1977
19
Ultrastructure of chromophobe adenoma of the human pituitary gland. ( 915598 )
1977
20
An unusual case of chromophobe adenoma with conspicuous calcifications. ( 920311 )
1977
21
Chromophobe adenoma manifesting as a nasopharyngeal mass. ( 971137 )
1976
22
Nasal obstruction caused by a pituitary chromophobe adenoma. ( 979497 )
1976
23
The fine structure of a prolactin-rich pituitary chromophobe adenoma (a case report). ( 977384 )
1976
24
Chromophobe adenoma and chiasmal syndrome without enlargement of the bony sella. ( 970854 )
1976
25
Third ventricular chromophobe adenoma with normal adenohypophysis. ( 961385 )
1976
26
Case of hyperthyroidism due to a chromophobe adenoma. ( 1269160 )
1976
27
Calcification in a chromophobe adenoma. Case report. ( 1262925 )
1976
28
Pathophysiological and pathogenic interpretation of the clinical picture of chromophobe adenoma of the hypophysis and of craniopharyngioma. ( 1053393 )
1976
29
The diagnostic problem of multiple intracranial tumours--case report of a pituitary chromophobe adenoma and cerebellar haemangioblastoma. ( 1240630 )
1975
30
Familial polyposis and pituitary chromophobe adenoma. ( 4528562 )
1974
31
Effects of surgical treatment on hypothalamo-pituitary-adrenocortical functions in pituitary chromophobe adenoma and craniopharyngioma. ( 4548402 )
1974
32
Chromophobe adenoma of the pituitary gland masquerading as bilateral nasal polypi--report of a case. ( 4818288 )
1974
33
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. ( 4369864 )
1974
34
Chromophobe adenoma presenting with a hemianopic temporal arcuate scotoma. ( 4813313 )
1974
35
Case report: spontaneous intracranial "aerocoele" with chromophobe adenoma. ( 4433985 )
1974
36
The role of visual fields and visual acuity in the treatment of chromophobe adenoma of the pituitary gland. A case report. ( 4423942 )
1974
37
Laser perimetry: diagnostic application in six cases of pituitary chromophobe adenoma. ( 4801814 )
1973
38
Pituitary chromophobe adenoma in a cat. ( 4779122 )
1973
39
Chromophobe adenoma of pituitary with acromegaly and acoustic neurinoma occurring in the same patient. A case report and review of the literature. ( 4539438 )
1973
40
Chromophobe adenoma of pituitary--the silent lesion. A case report. ( 4540952 )
1973
41
The fine structure of blood vessels in chromophobe adenoma. ( 4673965 )
1972
42
Fulminant meningitis associated with asymptomatic chromophobe adenoma. ( 5017859 )
1972
43
Metastasis of mammary carcinoma in a chromophobe adenoma of the hypophysis. ( 5138127 )
1971
44
Asymptomatic chromophobe adenoma in an eight-year-old child biopsied by stereotaxic technique and treated with cobalt-60. Case report. ( 4908799 )
1970
45
Chromophobe adenoma in a dog. ( 5202559 )
1970
46
Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma. ( 5470849 )
1970
47
Aldosterone secretion and plasma renin activity in chromophobe adenoma: effect of acth. ( 4320036 )
1970
48
Chromophobe adenoma of the pituitary in a dog. ( 5815850 )
1969
49
Pituitary apoplexy in a woman with chromophobe adenoma. ( 5803519 )
1969
50
Incidence of chromophobe adenoma after chronic diisopropylfluorophosphate poisoning. ( 5773849 )
1969

Variations for Chromophobe Adenoma

Expression for Chromophobe Adenoma

Search GEO for disease gene expression data for Chromophobe Adenoma.

Pathways for Chromophobe Adenoma

GO Terms for Chromophobe Adenoma

Cellular components related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 AVP GH1 GHRH GNRH1 INS POMC
2 extracellular space GO:0005615 9.8 AVP GH1 GHRH GNRH1 INS POMC
3 secretory granule GO:0030141 9.26 AVP POMC PRL TRH
4 endosome lumen GO:0031904 8.92 GH1 INS PRL PRLR

Biological processes related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.65 GNRH1 ITGA2 PRL
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 GH1 INS TP53
3 response to ethanol GO:0045471 9.56 AVP GNRH1 PRL TRH
4 positive regulation of JAK-STAT cascade GO:0046427 9.49 GH1 PRL
5 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.46 GH1 GHRH
6 cell-cell signaling GO:0007267 9.43 AVP GHRH GNRH1 INS POMC TRH
7 ovulation cycle GO:0042698 9.4 GNRH1 PRL
8 basic amino acid transmembrane transport GO:1990822 9.37 SLC7A3 SLC7A4
9 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.33 GH1 PRL PRLR
10 negative regulation of feeding behavior GO:2000252 9.32 INS TRH
11 response to organic cyclic compound GO:0014070 9.1 AVP GNRH1 ITGA2 PRL TET2 TRH

Molecular functions related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 AVP GH1 GNRH1 INS POMC PRL
2 basic amino acid transmembrane transporter activity GO:0015174 9.16 SLC7A3 SLC7A4
3 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Chromophobe Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....