CRCC
MCID: CHR177
MIFTS: 33

Chromophobe Renal Cell Carcinoma (CRCC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Chromophobe Renal Cell Carcinoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (rcc). chromophobe renal cell carcinoma makes up about 4-6% of rcc, and it is frequently diagnosed between ages 50 and 60. it is thought to have a more favorable prognosis than clear cell rcc, which is the main subtype of rcc. last updated: 11/2/2010

MalaCards: Chromophobe Renal Cell Carcinoma, also known as chromophobe renal cell adenocarcinoma, is related to renal oncocytoma and renal clear cell carcinoma. An important gene associated with Chromophobe Renal Cell Carcinoma is MME (membrane metallo-endopeptidase). The compounds estrogen and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

chromophobe renal cell carcinoma 42 48 60
chromophobe renal cell adenocarcinoma 48
chrcc 42
crcc 42


External Ids:

SNOMED-CT via Orphanet57 128667008
ICD10 via Orphanet26 C64

Related Diseases for Chromophobe Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Chromophobe Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma31.6PVALB, S100A1, FLCN, CDH16, CLDN8, KRT7
2renal clear cell carcinoma30.8S100A1, VIM, KRT7, MME, CLDN7, CDH16
3squamous cell carcinoma30.7VIM, S100A1, CTAG1B, MAGEA3, MAGEA4, EPCAM
4paraganglioma30.3S100A1, KIT
5renal cell carcinoma11.4
6sarcomatoid renal cell carcinoma10.8
7eosinophilic variant of chromophobe renal cell carcinoma10.7
8papillary carcinoma10.7
9papillary renal cell carcinoma10.7
10neuroendocrine carcinoma10.5
11osteosarcoma10.5
12bone carcinoma10.4
13birt-hogg-dube syndrome10.4
14small cell carcinoma10.4
15classic variant of chromophobe renal cell carcinoma10.4
16large cell carcinoma10.4
17cystic kidney10.4
18kidney disease10.4
19neuroendocrine tumor10.4
20renal cell carcinoma, clear cell, somatic10.4
21hypospadias10.2
22adrenal carcinoma10.2
23cervicitis10.2
24chromophobe adenocarcinoma10.2
25hepatitis10.2
26in situ carcinoma10.2
27seminal vesicle tumor10.2
28thyroiditis10.2
29lipoma10.0S100A1
30uterine carcinosarcoma10.0KIT
31cystadenoma10.0MME, KRT7
32adenoma10.0KRT7, S100A1
33endometrial carcinoma10.0KRT7, MME
34ocular melanoma10.0MAGEA3
35gout10.0HNF1B
36germ cell tumors10.0KIT
37nephrogenic adenoma10.0S100A1, KRT7
38sertoli cell tumor10.0VIM
39dysgerminoma10.0KRT7, KIT
40thymus cancer10.0KIT, KRT7
41metanephric adenoma10.0KRT7
42rhabdomyosarcoma10.0S100A1, VIM
43perineurioma10.0VIM, CLDN7
44adenosarcoma10.0MME
45teratoma10.0KRT7, KIT
46cholangiocarcinoma10.0KRT7, MAGEA3, MME
47colorectal cancer10.0KRT7, EPCAM, MAGEA3
48angiosarcoma10.0VIM
49seminoma10.0KIT, MAGEA4
50granular cell tumor10.0VIM, S100A1

Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to chromophobe renal cell carcinoma

Clinical Features for Chromophobe Renal Cell Carcinoma

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Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Chromophobe Renal Cell Carcinoma

Search NIH Clinical Center for Chromophobe Renal Cell Carcinoma

Search CenterWatch for Chromophobe Renal Cell Carcinoma

Genetic Tests for Chromophobe Renal Cell Carcinoma

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Anatomical Context for Chromophobe Renal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

32
Kidney

Animal Models for Chromophobe Renal Cell Carcinoma or affiliated genes

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Publications for Chromophobe Renal Cell Carcinoma

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Genetic Variations for Chromophobe Renal Cell Carcinoma

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Expression for genes affiliated with Chromophobe Renal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chromophobe Renal Cell Carcinoma

Search GEO for disease gene expression data for Chromophobe Renal Cell Carcinoma.

Pathways for genes affiliated with Chromophobe Renal Cell Carcinoma

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Compounds for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6PVALB
2monochloroacetic acid4410.5KIT, VIM
3toluidine4410.5KIT, S100A1, VIM
4mucicarmine4410.4VIM, S100A1, KRT7
5b 7234410.4KRT7, S100A1, VIM
62-methoxyethanol4410.4S100A1, VIM
7hematoxylin4410.4VIM, S100A1, KIT, KRT7
8formaldehyde44 2411.3VIM, PVALB, KIT, KRT7
9methionine4410.3KIT, MME, PVALB, VIM
10cytarabine44 49 1112.2KIT, MME, VIM
11histamine44 28 2412.2VIM, PVALB, MME, KIT
12reticulin4410.2KRT7, VIM
13progesterone44 59 28 11 2414.1VIM, S100A1, MME, KIT, KRT7
14acetylcholine44 49 28 11 2414.1VIM, PVALB, S100A1, MME
15retinoic acid44 2411.1VIM, HNF1B, S100A1, MME, KIT, KRT7
16glycogen44 2411.0KRT7, KIT, S100A1, VIM
17paraffin449.9KRT7, VIM, PVALB, S100A1, MAGEA3, EPCAM
18oligonucleotide449.7VIM, HNF1B, MAGEA3, CLDN7, KIT

GO Terms for genes affiliated with Chromophobe Renal Cell Carcinoma

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16Gene Ontology
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Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:0059239.9CLDN7, CLDN8, EPCAM
2integral to membraneGO:0160219.4PRSS8, MAL2, CDH16, EPCAM, RNF139, CLDN8

Molecular functions related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.0KRT7, HNF1B, S100A1, FLCN, PRSS8, MAGEA3

Products for genes affiliated with Chromophobe Renal Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chromophobe Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet