CRCC
MCID: CHR177
MIFTS: 37

Chromophobe Renal Cell Carcinoma (CRCC) malady

Rare diseases, Nephrological diseases, Cancer diseases categories
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Summaries for Chromophobe Renal Cell Carcinoma

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NIH Rare Diseases:42 Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (rcc). chromophobe renal cell carcinoma makes up about 4-6% of rcc, and it is frequently diagnosed between ages 50 and 60. it is thought to have a more favorable prognosis than clear cell rcc, which is the main subtype of rcc. last updated: 11/2/2010

MalaCards based summary: Chromophobe Renal Cell Carcinoma, also known as chromophobe renal cell adenocarcinoma, is related to renal oncocytoma and renal cell carcinoma. An important gene associated with Chromophobe Renal Cell Carcinoma is PSMB9 (proteasome (prosome, macropain) subunit, beta type, 9), and among its related pathways are WNT Signaling and Presenilin-Mediated Signaling. The compound aprotinin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow, and related mouse phenotype immune system.

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Chromophobe Renal Cell Carcinoma, Aliases & Descriptions:

Name: Chromophobe Renal Cell Carcinoma 30 42 48 62
Chromophobe Renal Cell Adenocarcinoma 48
 
Chrcc 42
Crcc 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

ICD10 via Orphanet26 C64
UMLS via Orphanet63 C1266042

Related Diseases for Chromophobe Renal Cell Carcinoma

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Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to chromophobe renal cell carcinoma

Symptoms for Chromophobe Renal Cell Carcinoma

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Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Chromophobe Renal Cell Carcinoma

Search NIH Clinical Center for Chromophobe Renal Cell Carcinoma

Genetic Tests for Chromophobe Renal Cell Carcinoma

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Anatomical Context for Chromophobe Renal Cell Carcinoma

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MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

32
Kidney, Liver, Bone marrow, Bone, Lymph node, Colon, Thyroid

Animal Models for Chromophobe Renal Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Chromophobe Renal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1HNF1B, PSMB9, PRSS8, MME, FLCN

Publications for Chromophobe Renal Cell Carcinoma

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Articles related to Chromophobe Renal Cell Carcinoma:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Clinical behavior of chromophobe renal cell carcinoma is less aggressive than that of clear cell renal cell carcinoma, independent of Fuhrman grade or tumor size. (25178561)
2014
2
Monocyte-derived dendritic cells reflect the immune functional status of a chromophobe renal cell carcinoma patient: Could it be a general phenomenon? (25314913)
2014
3
Omental Nodular Deposits of Recurrent Chromophobe Renal Cell Carcinoma Seen on FDG-PET/CT. (25337437)
2014
4
Predominantly tubular chromophobe renal cell carcinoma: an unusual histological presentation reminiscent of a neuroendocrine tumor. (23704098)
2013
5
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. (23953228)
2013
6
Interobserver reproducibility of a grading system for chromophobe renal cell carcinoma. (23058995)
2013
7
Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors. (23338778)
2013
8
Colon metastasis of chromophobe renal cell carcinoma with sarcomatoid change. (22964308)
2012
9
Chromophobe renal cell carcinoma with neuroendocrine differentiation and sarcomatoid change. (21884307)
2011
10
Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21: poorly differentiated form or "presarcomatoid" form? (21922389)
2011
11
Chromophobe renal cell carcinoma with prolonged response to sequential sunitinib and everolimus. (21245426)
2011
12
Two cases of eosinophilic variant chromophobe renal cell carcinoma, with a rare association of right atrial myxoma in one of them. (22219567)
2011
13
Temsirolimus in metastatic chromophobe renal cell carcinoma after interferon and sorafenib therapy. (21273619)
2011
14
Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. (21379425)
2011
15
Dedifferentiated chromophobe renal cell carcinoma with massive osteosarcoma-like divergent differentiation: a singular entity in the spectrum of retroperitoneal calcifying tumors. (19098016)
2010
16
Molecular pathology of chromophobe renal cell carcinoma: a review. (20590942)
2010
17
Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case. (20606735)
2010
18
MRI features of renal oncocytoma and chromophobe renal cell carcinoma. (21098174)
2010
19
Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. (20462447)
2010
20
Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. (20023267)
2010
21
Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? (20024582)
2010
22
Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. (19680475)
2009
23
A giant chromophobe renal cell carcinoma exceeding 10 kg. (20002842)
2009
24
Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (19302533)
2009
25
CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. (19386349)
2009
26
Chromophobe renal cell carcinoma with neuroendocrine differentiation. (19024610)
2008
27
Chromophobe renal cell carcinoma with calcification: Report of a case with rare finding on aspiration smears. (18677748)
2008
28
Words of wisdom. Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (19051381)
2008
29
Chromophobe renal cell carcinoma in a child: case report and review of the literature. (17378685)
2007
30
Simultaneous occurrence of metastasizing carcinoid tumour of the gallbladder and chromophobe renal cell carcinoma in a young man. (18330096)
2007
31
Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: a case report. (17669599)
2007
32
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16927643)
2006
33
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
34
KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. (15832088)
2005
35
Toluidine positivity in chromophobe renal cell carcinoma: use in intraoperative diagnosis. (16242003)
2005
36
Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. (16337860)
2005
37
Chromophobe renal cell carcinoma: analysis of 61 cases. (15042674)
2004
38
Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (14702167)
2004
39
Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. (15198361)
2004
40
Chromophobe renal cell carcinoma showing oncocytoma-like hyalinized and edematous stroma: A case report and review of the literature. (15610861)
2004
41
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. (12507296)
2003
42
Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12352424)
2002
43
FISH analysis in chromophobe renal-cell carcinoma. (10613963)
2000
44
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000
45
Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma. (10765081)
2000
46
Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma: comparison of cytomorphologic features. (10385448)
1999
47
Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. (9844591)
1998
48
A case of chromophobe renal cell carcinoma with sarcomatoid foci and a small daughter lesion. (9788266)
1998
49
Chromophobe renal cell carcinoma: clinicopathological study of 7 cases. (9491212)
1998
50
Aggressive variants of chromophobe renal cell carcinoma. (8859189)
1996

Variations for Chromophobe Renal Cell Carcinoma

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Expression for genes affiliated with Chromophobe Renal Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Chromophobe Renal Cell Carcinoma

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Pathways for genes affiliated with Chromophobe Renal Cell Carcinoma

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Pathways related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH16, PSMB9
29.6CDH16, PSMB9

Compounds for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources:
44Novoseek, 11DrugBank
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Compounds related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aprotinin44 1110.5PRSS8, MME

GO Terms for genes affiliated with Chromophobe Renal Cell Carcinoma

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Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7CDH16, PRSS8, MME, FLCN, CLDN8

Biological processes related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.4HNF1B, MME

Products for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources for Chromophobe Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet