Chromophobe Renal Cell Carcinoma malady

NIH Rare Diseases: Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (RCC). Chromophobe renal cell carcinoma makes up about 4-6% of RCC, and it is frequently diagnosed between ages 50 and 60. It is thought to have a more favorable prognosis than clear cell RCC, which is the main subtype of RCC.³⁰

MalaCards: Chromophobe Renal Cell Carcinoma, also known as chrcc, is related to renal oncocytoma and cystic kidney. An important gene associated with Chromophobe Renal Cell Carcinoma is CLDN8 (claudin 8), and among its related pathways are Adhesion and Cytoskeleton remodeling Keratin filaments. The compounds egcg and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

chromophobe renal cell carcinoma 30 43 chrcc 30

crcc 30

Diseases related to chromophobe renal cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 419)

id	Related Disease	Score	Top Affiliating Genes
1	renal oncocytoma	32.2	KIT, PCNA, VIM, VHL, CLDN7, CLDN8
2	cystic kidney	30.5	VHL, HNF1B, EGF
3	renal cell carcinoma	28.8	KIT, PCNA, VIM, VHL, RARB, CLDN7
4	carcinoma	24.7	KIT, PCNA, VIM, VHL, RARB, CLDN7
5	uterine benign neoplasm	13.7	MAGEA4, CTAG1B
6	bile duct adenoma	13.6	KRT7, KRT19
7	ovarian large-cell neuroendocrine carcinoma	13.6	KRT7, KRT20
8	pancreatic mucinous cystadenoma	13.6	KIT, MME, KRT20
9	anal canal adenocarcinoma	13.6	KRT7, KRT19
10	paraurethral gland neoplasm	13.6	KRT7, KRT20
11	cirrhosis, noncryptogenic	13.6	KRT8, KRT18
12	cirrhosis, cryptogenic	13.6	KRT8, KRT18
13	supernumerary nipples	13.5	GPC3, KRT20
14	horseshoe kidney	13.5	MME, HNF1B, KRT7, KRT20
15	ossifying fibromyxoid tumor	13.5	VIM, S100A1, MME
16	hidrocystoma	13.5	KRT8, KRT7, KRT19
17	malignant mixed mullerian tumor	13.5	KIT, VIM, MME
18	breast malignant phyllodes tumor	13.5	KIT, VIM, MME
19	pancreatic ductal carcinoma	13.5	KRT8, KRT7, KRT20
20	brooke-spiegler syndrome	13.5	VIM, KRT8, KRT7
21	endometrial stromal sarcoma	13.5	KIT, VIM, MME
22	papillary adenoma	13.5	VIM, KRT7, OGG1
23	oxyphilic adenoma	13.4	CLDN7, CLDN8, S100A1, CDH16, FLCN, PVALB
24	dermoid cyst of ovary	13.4	VIM, KRT20
25	dysgerminoma	13.4	KIT, MAGEA4, CTAG1B, RNF139, KRT7
26	mixed cell type cancer	13.4	VIM, KRT7, KRT20
27	spindle cell sarcoma	13.4	VIM, KRT8, KRT7
28	nephrogenic adenoma	13.4	MUC1, CDH16, KRT7
29	pulmonary large cell neuroendocrine carcinoma	13.4	KRT8, KRT7, KRT18, KRT19
30	pseudomyxoma peritonei	13.4	VIM, KRT7, KRT20
31	bladder adenocarcinoma	13.4	KRT7, KRT20
32	endometrial stromal tumor	13.4	VIM, MME, CCND1
33	lipoma	13.3	VIM, S100A1, FLCN, PROM2
34	mammary paget's disease	13.3	MUC1, KRT7, KRT20
35	ampulla of vater adenocarcinoma	13.3	MUC1, KRT7, KRT20
36	chondroblastoma	13.3	VIM, S100A1, KRT8, KRT7
37	cutaneous paget's disease	13.3	MUC1, KRT7, KRT20
38	hereditary pancreatitis	13.3	MAGEA4, CTAG1B, KRT8, KRT18
39	clear cell ependymoma	13.3	VIM, MUC1
40	prostate stromal sarcoma	13.3	VIM, MUC1
41	basal cell carcinoma	13.3	MME, KRT8, KRT7, KRT20, KRT19
42	leiomyomatosis	13.3	VIM, VHL, FLCN
43	hepatic adenoma	13.3	PCNA, KRT7, KRT19
44	tubular adenocarcinoma	13.3	MUC1, MME, KRT7, KRT20
45	metanephric adenoma	13.2	VIM, MUC1, KRT7
46	myxopapillary ependymoma	13.2	VIM, MUC1, KRT7
47	bowen syndrome	13.2	PCNA, KRT7, KRT19
48	cervical endometrioid adenocarcinoma	13.2	MUC1, MME, KRT7, KRT20
49	adenoid squamous cell carcinoma	13.2	VIM, MUC1
50	chondroid chordoma	13.2	VIM, MUC1, S100A1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to chromophobe renal cell carcinoma:

²²

MGI Mouse Phenotypes related to chromophobe renal cell carcinoma:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	CAV1
2	respiratory system phenotype	MP:0005388	10.2	PBRM1
3	craniofacial phenotype	MP:0005382	9.7	KIT, GPC3, CSF2
4	normal phenotype	MP:0002873	9.6	VHL, RARB, PVALB, PRSS8, OGG1
5	liver/biliary system phenotype	MP:0005370	9.1	HNF1B, MET, VHL, KIT, EGFR
6	reproductive system phenotype	MP:0005389	8.7	VHL, RARB, CCND1, GPC3, CAV1, KRT8
7	hematopoietic system phenotype	MP:0005397	8.2	EPCAM, KRT8, GPC3, CCND1, CLDN7, PCNA
8	immune system phenotype	MP:0005387	8.0	HNF1B, SLC4A1, CSF2, PRSS8, EGFR, KRT8
9	muscle phenotype	MP:0005369	7.4	S100A1, KIT, SLC4A1, PVALB, EGFR, HNF1B
10	renal/urinary system phenotype	MP:0005367	7.2	CLDN7, RARB, VHL, KIT, FLCN, MET
11	skeleton phenotype	MP:0005390	6.8	CSF2, CD9, RARB, VHL, KIT, CCND1
12	embryogenesis phenotype	MP:0005380	6.8	KRT18, KRT8, KIT, PBRM1, RARB, VHL
13	tumorigenesis	MP:0002006	6.7	MUC1, KIT, VHL, OGG1, ACE, EGFR
14	integument phenotype	MP:0010771	6.2	VHL, CAV1, GPC3, CLDN7, CCND1, MUC1
15	mortality/aging	MP:0010768	6.0	CCND1, MET, FLCN, PBRM1, CLDN7, RARB
16	digestive/alimentary phenotype	MP:0005381	5.9	MUC1, KRT19, TGFA, PXN, EGFR, KIT
17	homeostasis/metabolism phenotype	MP:0005376	5.8	GPC3, CCND1, MET, FLCN, MME, MUC1
18	cellular phenotype	MP:0005384	5.6	MET, PVALB, PXN, OGG1, CSF2, SLC4A1
19	cardiovascular system phenotype	MP:0005385	5.6	RARB, KRT19, KIT, VIM, VHL, PBRM1
20	growth/size phenotype	MP:0005378	4.3	FLCN, PXN, TGFA, ACE, EGFR, EGF

Articles related to chromophobe renal cell carcinoma:

(show all 37)

id	Title	Authors	Year	Affiliating Genes
1	Insertion/deletion polymorphism of angiotensin I-conv erting enzyme gene is linked with chromophobe renal cell carcinoma. (21477733)	de Martino M.... Marberger M.	2011	ACE
2	Immunohistochemical expression of tumor antigens MAGE -A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. (20591578)	DemiroviA8 A.... KruA!lin B.	2010	MAGEA4, MAGEA3, CTAG1B
3	Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (19302533)	Kim S.S.... Choi C.	2009	KRT7, S100A1, CLDN8
4	Does CD10 immunoexpression have a diagnostic utility in the differential diagnosis of renal oncocytomas and eosinophilic variants of chromophobe renal cell carcinomas? (19152193)	Mete O.... Uysal V.	2009	MME
5	CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differ entiation from chromophobe renal cell carcinoma. (19386349)	Sukov W.R.... Cheville J.C.	2009	CCND1
6	Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (18799195)	Osunkoya A.O.... Young A.N.	2009	CLDN7, CLDN8
7	Glypican-3 is expressed in chromophobe renal cell carcinomas. (18655366)	Okon K.	2008	GPC3
8	Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. (18603673)	Geramizadeh B.... Rahsaz M.	2008	VIM, MME, MUC1
9	Squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma: an unusual case report with review of the literature. (18834228)	Viswanathan S.... Amin M.B.	2008	CDH16
10	Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma. (17133269)	Gad S.... Richard S.	2007	FLCN, HNF1B
11	Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. (17449941)	Choi Y.D.... Choi C.	2007	CLDN7, PVALB
12	Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. (17922590)	Hornsby C.D.... Young A.N.	2007	CLDN7, CLDN8
13	S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. (17394501)	Li G.... Tostain J.	2007	S100A1
14	Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. (17683191)	Liu L.... Bostwick D.G.	2007	KIT, VIM, KRT7
15	Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16927643)	Adley B.P.... Yang X.J.	2006	KRT7, PVALB
16	Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell jun ction proteins as differentially expressed genes. (17145811)	Rohan S.... Chen Y.T.	2006	PRSS8, CLDN8, AP1M2
17	Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. (16753598)	Adley B.P.... Yang X.J.	2006	CDH16
18	Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16613342)	Garcia E.... Li M.	2006	CAV1, KRT7
19	RAR-beta(1) overexpression in chromophobe renal cell carcinoma: a novel target for therapeutic intervention? (16244585)	Goelden U.... Schrader A.J.	2005	RARB
20	C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas. (15791570)	Huo L.... Yang X.J.	2005	KIT
21	Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. (16337860)	Salido M.... SolAc F.	2005	CCND1
22	Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. (15712178)	Mazal P.R.... Susani M.	2005	VIM, KRT7, CDH16
23	Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1 beta) mutations. (16932376)	Lebrun G.... Grunfeld J.P.	2005	HNF1B
24	Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (14702167)	Kuroda N.... Enzan H.	2004	KRT7
25	CD10 is expressed in a subset of chromophobe renal cell carcinomas. (15286660)	Martignoni G.... Bonetti F.	2004	MME, PVALB
26	Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. (15198361)	Pan C.C.... Chiang H.	2004	KIT
27	KIT expression in chromophobe renal cell carcinoma: comparative immunohistochemical analysis of KIT expression in different renal cell neoplasms. (15105658)	Petit A.... MallofrAc C.	2004	KIT
28	Chromophobe renal cell carcinoma: a comparative study of histological, immunohistochemical and ultrastructural features using high throughput tissue microarray. (15569050)	Abrahams N.A.... Tickoo S.K.	2004	VIM, KRT7, PVALB
29	Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. (14961590)	Nagy A.... Kovacs G.	2004	FLCN
30	Overexpression of KIT in chromophobe renal cell carcinoma. (12584564)	Yamazaki K.... Hirohashi S.	2003	KIT
31	Rhabdoid differentiation of chromophobe renal cell carcinoma. (14506967)	Shannon B.A.... Cohen R.J.	2003	VIM
32	Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma. (11759057)	Kuroda N.... Enzan H.	2001	PXN
33	Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas. (11679941)	Kuroda N.... Enzan H.	2001	CD9
34	Chromophobe renal cell carcinoma with sarcomatoid change. A case report. (10997740)	Nagashima Y.... Aoki I.	2000	VIM
35	Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma. (10765081)	Leroy X.... Gosselin B.	2000	KRT7
36	Lack of interleukin 6 (IL-6) and transforming growth factor alpha (TGF-alpha) expression in chromophobe renal cell carcinomas. (9820173)	Chudek J.... Kovacs G.	1998	EGFR, EGF, CSF2
37	Chromophobe renal cell carcinoma: immunohistochemical study of 7 cases (9412189)	GonzA!lez-MA-nguez C.L.... Vidal-Rosell M.T.	1997	VIM, SLC4A1, PCNA

Genes related to chromophobe renal cell carcinoma according to GeneCards:

(show all 43)

id	Symbol	Description	Score	GeneCards Section Context
1	CLDN8	claudin 8	11.1	Publications, Summaries
2	MME	membrane metallo-endopeptidase	11.0	Publications
3	CDH16	cadherin 16, KSP-cadherin	11.0	Publications
4	FLCN	folliculin	11.0	Publications
5	CLDN7	claudin 7	11.0	Publications
6	PROM2	prominin 2	11.0	Publications
7	RNF139	ring finger protein 139	11.0
8	PRSS8	protease, serine, 8	11.0	Publications
9	AP1M2	adaptor-related protein complex 1, mu 2 subunit	11.0	Publications
10	KRT7	keratin 7	11.0	Publications
11	MAGEA4	melanoma antigen family A, 4	11.0	Publications
12	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	11.0	Publications
13	PVALB	parvalbumin	11.0	Publications
14	CTAG1B	cancer/testis antigen 1B	11.0	Publications
15	MAGEA3	melanoma antigen family A, 3	11.0	Publications
16	ESRP1	epithelial splicing regulatory protein 1	11.0	Publications
17	S100A1	S100 calcium binding protein A1	11.0	Publications
18	HNF1B	HNF1 homeobox B	11.0	Publications
19	EPCAM	epithelial cell adhesion molecule	11.0	Publications
20	GPC3	glypican 3	11.0	Publications
21	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications
22	VIM	vimentin	11.0	Publications
23	OGG1	8-oxoguanine DNA glycosylase	11.0
24	PBRM1	polybromo 1	11.0
25	PXN	paxillin	11.0	Publications
26	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0
27	KRT8	keratin 8	11.0	Publications
28	CD9	CD9 molecule	11.0	Publications
29	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
30	KRT18	keratin 18	11.0	Publications
31	KRT20	keratin 20	11.0	Publications
32	KRT19	keratin 19	11.0	Publications
33	RARB	retinoic acid receptor, beta	11.0	Publications
34	CAV1	caveolin 1, caveolae protein, 22kDa	11.0	Publications
35	CCND1	cyclin D1	11.0	Publications
36	TGFA	transforming growth factor, alpha	11.0	Publications
37	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
38	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0
39	MUC1	mucin 1, cell surface associated	11.0	Publications
40	PCNA	proliferating cell nuclear antigen	11.0	Publications
41	EGFR	epidermal growth factor receptor	11.0	Publications
42	EGF	epidermal growth factor	11.0	Publications
43	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications

Pathways related to chromophobe renal cell carcinoma according to GeneDecks:

(show all 40)

id	Pathway	Score	Top Affiliating Genes
1	Adhesion3	10.5	EPCAM, PXN
2	Cytoskeleton remodeling Keratin filaments10	9.9	KRT18, KRT7, KRT8, VIM, KRT19
3	Cytoskeleton remodeling_Keratin filaments41	9.9	VIM, KRT19, KRT18, KRT7, KRT8
4	Renal cell carcinoma20	9.8	TGFA, MET, VHL
5	Hematopoietic cell lineage20	9.7	CSF2, MME, KIT, CD9
6	Non-small cell lung cancer20	9.7	TGFA, EGF
7	Akt Signaling36	9.5	MET, CSF2, CCND1, KIT
8	JNK Pathway36	9.5	EGF, KIT
9	Cytoskeletal Signaling3	9.4	EPCAM, VIM, CAV1, KRT8, KRT7, KRT18
10	Signal transduction PTEN pathway10	9.3	PXN, PCNA, EGF
11	Rho Family GTPases36	9.2	CDH16, MET, TGFA, CSF2, KIT, VIM
12	ERK5 Signaling36	8.9	TGFA, EGFR, MET, KIT
13	Development Ligand-independent activation of ESR1 and ESR210	8.8	EGF, CAV1, EGFR, CCND1
14	Development_Ligand-independent activation of ESR1 and ESR241	8.8	EGF, CCND1, CAV1, EGFR
15	Glioma20	8.7	CCND1, EGF, EGFR, TGFA
16	Signal transduction_PTEN pathway41	8.7	EGFR, PCNA, EGF, PXN
17	Melanoma20	8.6	CCND1, MET, EGF, EGFR
18	PAK Pathway36	8.5	KIT, CSF2, PXN, TGFA, EGFR, MET
19	Prostate cancer20	8.5	EGF, EGFR, CCND1, TGFA
20	PTEN Pathway36	8.5	MET, KIT, EGF, EGFR, PXN
21	EGF Pathway36	8.5	MUC1, CAV1, PXN, EGFR, EGF
22	Apoptotic Pathways in Synovial Fibroblasts36	8.4	TGFA, EGF, MET, KIT, EGFR
23	p53 Mediated Apoptosis36	8.3	EGF, KIT, EGFR, TGFA, MET
24	Mitochondrial Apoptosis36	8.3	TGFA, KIT, MET, EGF, EGFR
25	DHA Signaling36	8.2	EGFR, MET, TGFA, KIT, EGF
26	Paxillin Interactions36	8.2	KIT, MET, EGF, PXN, TGFA, EGFR
27	Focal adhesion20	8.2	MET, EGFR, EGF, PXN, CAV1, CCND1
28	GSK3 Signaling36	8.2	MET, EGF, TGFA, EGFR, KIT, CDH16
29	Nuclear Receptor Activation by Vitamin-A36	8.2	RARB, EGFR, KIT, TGFA, EGF, MET
30	GPCR Pathway36	8.1	EGF, KIT, MET, TGFA, PXN, EGFR
31	Pathways in cancer20	8.1	TGFA, EGF, CCND1, RARB, EGFR, MET
32	eNOS Signaling36	8.1	EGFR, TGFA, EGF, CAV1, MET, KIT
33	Pancreatic Adenocarcinoma36	8.1	CCND1, EGF, EGFR, TGFA, MET, KIT
34	Cellular Apoptosis Pathway36	8.0	TGFA, EGF, EGFR, MET, KIT
35	eIF2 Pathway36	8.0	TGFA, EGFR, MET, KIT, EGF
36	Molecular Mechanisms of Cancer36	8.0	EGFR, EGF, TGFA, RARB, CCND1, MET
37	Estrogen Pathway36	8.0	EGFR, MET, KIT, CCND1, EGF, TGFA
38	Endocytosis20	8.0	EGFR, MET, EGF, KIT, CAV1
39	PPAR Pathway36	7.7	KIT, MET, EGF, EGFR, TGFA
40	ILK Signaling36	7.0	KIT, PXN, TGFA, EGFR, EGF, KRT18

Compounds related to chromophobe renal cell carcinoma according to GeneDecks:

(show top 50)    (show all 142)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.6	KRT18
2	mucicarmine32	9.6	VIM, MUC1, S100A1, KRT7, KRT20
3	glucose32	9.5	KIT, VHL, MME, KRT8, KRT7, KRT18
4	ly29400232	9.5	CCND1, PXN, CAV1, VHL
5	acyclic retinoid32	9.1	EGFR, CCND1, TGFA, RARB
6	5-aza-2deoxycytidine32	8.8	KRT7, CTAG1B, CAV1, VIM, GPC3, RARB
7	b 72332	8.8	KRT8, S100A1, VIM, PCNA, MUC1, KRT7
8	adriamycin32	8.7	OGG1, VIM, MME, MUC1, MET, CCND1
9	folate32	8.6	OGG1, TGFA, CAV1, CCND1, VIM, VHL
10	iron32 18	9.5	PVALB, KRT19, KRT8, KRT20, KRT18, S100A1
11	12-o-tetradecanoylphorbol 13-acetate32	8.5	RARB, MME, CSF2, PXN, TGFA, EGF
12	geldanamycin32 9 9	10.4	PXN, EGFR, EGF, CCND1, MET
13	hematoxylin32	8.3	KRT18, KRT8, KIT, KRT20, KRT7, PCNA
14	ribonucleic acid32	8.2	KIT, TGFA, KRT19, RARB, MUC1, CD9
15	retinoid32	8.1	CCND1, KRT7, KRT18, EGFR, RARB, VIM
16	fulvestrant32 34 9 9	11.1	EGFR, KRT18, EGF, TGFA, PCNA
17	rapamycin32 42	9.0	KIT, EGFR, VIM, EGF, VHL, MET
18	lactate32	8.0	KIT, KRT18, TGFA, PCNA, VIM, MME
19	glycogen32 18	8.9	VIM, KRT18, VHL, MUC1, S100A1, MET
20	trastuzumab32 34 9 9	10.9	MUC1, CCND1, EGF, EGFR, TGFA, EPCAM
21	gefitinib32 34 9 9	10.9	KIT, EGF, VIM, MET, CCND1, TGFA
22	bromodeoxyuridine32	7.9	KRT19, PCNA, TGFA, KRT18, VIM, MME
23	formaldehyde32 18	8.8	KIT, PCNA, VIM, MUC1, KRT7, KRT18
24	ag 147832	7.5	MET, CCND1, EGF, TGFA, EGFR, PXN
25	phosphotyrosine32	7.3	KIT, TGFA, EGFR, EGF, KRT8, CAV1
26	nitric oxide32 9 18 9	10.3	OGG1, PRSS8, PVALB, MET, PXN, KIT
27	retinoic acid32 42 18	9.2	KIT, MME, MET, CCND1, HNF1B, KRT8
28	butyrate32	7.1	KRT18, MUC1, CSF2, TGFA, EGF, PCNA
29	vegf32	7.1	CSF2, PXN, KRT19, KRT20, KRT18, KRT7
30	actinomycin d32	7.0	MME, MUC1, RARB, KIT, VIM, MET
31	5fluorouracil32	7.0	EGFR, TGFA, EGF, EPCAM, KRT18, MUC1
32	paclitaxel32 34 9 9	10.0	TGFA, EGFR, EGF, KRT19, KRT8, CCND1
33	steroid32	7.0	KIT, EGF, TGFA, PXN, RARB, KRT18
34	matrigel32	7.0	CCND1, KRT18, MUC1, MME, MET, CAV1
35	oligonucleotide32	6.7	MET, CLDN7, RARB, VIM, PCNA, KIT
36	tamoxifen32 34 9 9	9.7	EGFR, CAV1, MUC1, CSF2, PCNA, TGFA
37	estrogen32	6.7	KRT20, TGFA, KRT8, S100A1, RARB, PCNA
38	doxorubicin32 34 9 9	9.5	CSF2, VIM, TGFA, KIT, MME, MET
39	cycloheximide32	6.4	VIM, RARB, MME, MET, CCND1, CAV1
40	phosphatidylinositol32	6.4	PXN, EGFR, EGF, CAV1, CCND1, CSF2
41	agar32	6.3	VIM, RARB, MUC1, MET, CCND1, CAV1
42	cysteine32	6.3	PXN, KRT8, SLC4A1, CSF2, OGG1, CD9
43	cisplatin32 34 9 9	9.2	CSF2, EGFR, KRT19, KRT8, CAV1, CCND1
44	genistein32 9 18 9	9.1	PXN, CSF2, PCNA, TGFA, EGF, KRT8
45	thymidine32 18	7.0	OGG1, EPCAM, RARB, CSF2, PCNA, KIT
46	paraffin32	5.6	KRT19, KRT20, KRT18, KRT7, KRT8, CAV1
47	serine32	5.5	VHL, VIM, KIT, TGFA, PXN, PVALB
48	testosterone32 9 18 9	8.2	EGF, EGFR, TGFA, PCNA, KRT19, MME
49	progesterone32 42 9 18 9	8.9	KRT8, PXN, KIT, PCNA, VIM, TGFA
50	tyrosine32	4.5	KRT7, MUC1, CCND1, CAV1, PVALB, KRT8

Cellular components related to chromophobe renal cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apical plasma membrane	GO:016324	9.6	CD9, MAL2, CAV1, PROM2, EPCAM
2	intermediate filament	GO:005882	9.3	KRT8, KRT19, KRT20, KRT18, KRT7, VIM
3	basolateral plasma membrane	GO:016323	8.8	CAV1, SLC4A1, PROM2, TGFA, EGFR, EPCAM
4	extracellular space	GO:005615	6.6	ACE, MET, GPC3, EGF, EGFR, TGFA
5	plasma membrane	GO:005886	5.4	PRSS8, CAV1, ESRP1, EGF, EGFR, ACE

Biological processes related to chromophobe renal cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	response to UV-A	GO:070141	9.5	CCND1, EGFR
2	branching morphogenesis of a tube	GO:048754	9.1	HNF1B, MET, EGF
3	virus-host interaction	GO:019048	9.1	KRT19, KRT18, KRT7, KRT8, CAV1, VIM
4	mammary gland alveolus development	GO:060749	9.1	TGFA, CCND1, EGF
5	positive regulation of mitosis	GO:045840	8.6	TGFA, EGF, MET

Molecular functions related to chromophobe renal cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	9.1	KRT18, CLDN7, KRT7, KRT8, CAV1, CLDN8
2	identical protein binding	GO:042802	8.8	S100A1, CLDN8, CLDN7, VIM, PCNA, EGFR
3	protein binding	GO:005515	1.5	CLDN7, MAGEA3, MAGEA4, CCND1, GPC3, PXN