CRCC
MCID: CHR177
MIFTS: 39

Chromophobe Renal Cell Carcinoma (CRCC) malady

Nephrological, Cancer categories

Summaries for Chromophobe Renal Cell Carcinoma

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (rcc). chromophobe renal cell carcinoma makes up about 4-6% of rcc, and it is frequently diagnosed between ages 50 and 60. it is thought to have a more favorable prognosis than clear cell rcc, which is the main subtype of rcc. last updated: 11/2/2010

MalaCards: Chromophobe Renal Cell Carcinoma, also known as chromophobe renal cell adenocarcinoma, is related to renal clear cell carcinoma and squamous cell carcinoma. An important gene associated with Chromophobe Renal Cell Carcinoma is MME (membrane metallo-endopeptidase). The compounds estrogen and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lymph node.

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Aliases & Descriptions:

chromophobe renal cell carcinoma 43 49 61
chromophobe renal cell adenocarcinoma 49
chrcc 43
crcc 43


External Ids:

ICD10 via Orphanet26 C64

Related Diseases for Chromophobe Renal Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chromophobe Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma30.9VIM, PVALB, S100A1, CDH16, CLDN7, MME
2squamous cell carcinoma30.7VIM, S100A1, CTAG1B, MAGEA3, MAGEA4, EPCAM
3adenoma30.4S100A1, KRT7
4paraganglioma30.4KIT, S100A1
5sarcomatoid renal cell carcinoma10.9
6papillary carcinoma10.7
7papillary renal cell carcinoma10.7
8papillary renal carcinoma10.7
9clear cell renal cell carcinoma10.6
10neuroendocrine carcinoma10.6
11bone carcinoma10.4
12birt-hogg-dube syndrome10.4
13small cell carcinoma10.4
14classic variant of chromophobe renal cell carcinoma10.4
15eosinophilic variant of chromophobe renal cell carcinoma10.4
16large cell carcinoma10.4
17birt–hogg–dubé syndrome10.4
18birt-hogg-dub� syndrome10.4
19renal cell carcinoma, clear cell, somatic10.4
20hypospadias10.3
21microcystic adenoma10.3
22adrenal carcinoma10.3
23granular cell carcinoma10.3
24chromophobe adenoma10.3
25small cell sarcoma10.3
26basal cell carcinoma10.3
27lipoma10.0S100A1
28uterine carcinosarcoma10.0KIT
29cystadenoma10.0MME, KRT7
30endometrial carcinoma10.0KRT7, MME
31ocular melanoma10.0MAGEA3
32gout10.0HNF1B
33germ cell tumors10.0KIT
34nephrogenic adenoma10.0KRT7, S100A1
35sertoli cell tumor10.0VIM
36dysgerminoma10.0KRT7, KIT
37thymic carcinoma10.0KIT, KRT7
38metanephric adenoma10.0KRT7
39rhabdomyosarcoma10.0S100A1, VIM
40perineurioma10.0CLDN7, VIM
41adenosarcoma10.0MME
42teratoma10.0KRT7, KIT
43cholangiocarcinoma10.0KRT7, MME, MAGEA3
44colorectal cancer10.0KRT7, EPCAM, MAGEA3
45angiosarcoma10.0VIM
46seminoma10.0KIT, MAGEA4
47granular cell tumor10.0VIM, S100A1
48angiomyolipoma10.0KIT, S100A1, VIM
49malignant mixed mullerian tumor10.0KIT, MME, VIM
50malignant mesothelioma10.0VIM, S100A1, KRT7

Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to chromophobe renal cell carcinoma

Clinical Features for Chromophobe Renal Cell Carcinoma

Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chromophobe Renal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Chromophobe Renal Cell Carcinoma

Search NIH Clinical Center for Chromophobe Renal Cell Carcinoma

Search CenterWatch for Chromophobe Renal Cell Carcinoma

Genetic Tests for Chromophobe Renal Cell Carcinoma

Anatomical Context for Chromophobe Renal Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

33
Liver, Kidney, Lymph node, Bone marrow, Colon, Thyroid, Adrenal gland

Animal Models for Chromophobe Renal Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Chromophobe Renal Cell Carcinoma

Sources:
51PubMed
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Articles related to Chromophobe Renal Cell Carcinoma:

(show top 50)    (show all 198)
idTitleAuthorsYear
1
Predominantly tubular chromophobe renal cell carcinoma: an unusual histological presentation reminiscent of a neuroendocrine tumor. (23704098)
2013
2
Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors. (23338778)
2013
3
Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma. (23688003)
2013
4
Chromophobe renal cell carcinoma--chromosomal aberration variability and its relation to Paner grading system: an array CGH and FISH analysis of 37 cases. (23913167)
2013
5
Chromophobe renal cell carcinoma with prolonged response to targeted therapy: a case report. (22524151)
2012
6
Utility of immunohistochemical analysis of KAI1, epithelial-specific antigen, and epithelial-related antigen for distinction of chromophobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma. (22718295)
2012
7
Chromophobe renal cell carcinoma with neuroendocrine differentiation and sarcomatoid change. (21884307)
2011
8
Two cases of eosinophilic variant chromophobe renal cell carcinoma, with a rare association of right atrial myxoma in one of them. (22219567)
2011
9
Temsirolimus in metastatic chromophobe renal cell carcinoma after interferon and sorafenib therapy. (21273619)
2011
10
Sarcomatoid chromophobe renal cell carcinoma with osteosarcoma-like differentiation which presented as a retroperitoneal mass: a case report. (21630206)
2011
11
The chromophobe tumor grading system is the preferred grading scheme for chromophobe renal cell carcinoma. (22014797)
2011
12
Imprint cytology of the chromophobe renal cell carcinoma: Correlation with the histological and ultrastructural features. (21713152)
2011
13
MRI features of renal oncocytoma and chromophobe renal cell carcinoma. (21098174)
2010
14
Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma? (19941365)
2010
15
Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. (20591578)
2010
16
Metachronous contralateral testicular and bilateral adrenal metastasis of chromophobe renal cell carcinoma: a case report and review of the literature. (20443217)
2010
17
Sarcomatoid chromophobe renal cell carcinoma: Cytohistopathological correlation of a case. (21042532)
2010
18
Monoclonal antibody Cam 5.2 targeted mainly CK8, but not CK18--Comment on: "Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation--report of a unique case. Int J Clin Exp Pathol. 2010 May 5; 3 (5):534-40.". (20830247)
2010
19
Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (18799195)
2009
20
Utility of tissue microarrays for assessment of chromosomal abnormalities in chromophobe renal cell carcinoma. (20698356)
2009
21
Synchronous chromophobe and papillary renal cell carcinoma. First report and review of the pathogenesis theories. (19261099)
2009
22
Words of wisdom. Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (19051381)
2008
23
Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (18165647)
2008
24
Solitary liver metastasis of chromophobe renal cell carcinoma 20 years after nephrectomy treated by hepatic resection. (18329075)
2008
25
Glypican-3 is expressed in chromophobe renal cell carcinomas. (18655366)
2008
26
Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma. (18216146)
2008
27
Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (18485320)
2008
28
Chromophobe renal cell carcinoma: useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants. (19107613)
2008
29
Chromophobe renal cell carcinoma: A report of two cases with unusual histological features. (19468377)
2008
30
Synchronous nephrectomy and right hepatectomy for metastatic chromophobe renal cell carcinoma: report of a case and review of the literature. (17500184)
2007
31
Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. (17449941)
2007
32
Sarcomatoid chromophobe renal cell carcinoma. A case report and review of the literature. (16649532)
2006
33
KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. (15832088)
2005
34
Chromophobe renal cell carcinoma with extensive rhabdomyosarcomatous component. (16021511)
2005
35
Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (14702167)
2004
36
Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. (15198361)
2004
37
Chromophobe renal cell carcinoma: a comparative study of histological, immunohistochemical and ultrastructural features using high throughput tissue microarray. (15569050)
2004
38
Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. (15252311)
2004
39
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. (12507296)
2003
40
Rhabdoid differentiation of chromophobe renal cell carcinoma. (14506967)
2003
41
Re: Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12771781)
2003
42
Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12352424)
2002
43
Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas. (11679941)
2001
44
Chromophobe renal cell carcinoma in pregnancy: case report and review of the literature. (11580745)
2001
45
Sarcomatoid renal cell carcinoma with chromophobe cell foci. Report of a case. (9833703)
1998
46
Sarcomatoid chromophobe cell renal carcinoma: immunohistochemical and lectin study in one case. (9269910)
1997
47
Sarcomatoid renal cell carcinoma: the chromophobe connection. (9331291)
1997
48
Aggressive variants of chromophobe renal cell carcinoma. (8859189)
1996
49
Chromophobe renal cell carcinoma. Pathologic, ultrastructural, immunohistochemical, cytofluorometric and cytogenetic findings. (9182300)
1996
50
Establishment and characterization of two divergent cell lines derived from a human chromophobe renal cell carcinoma. (7717462)
1995

Genetic Variations for Chromophobe Renal Cell Carcinoma

Expression for genes affiliated with Chromophobe Renal Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chromophobe Renal Cell Carcinoma

Search GEO for disease gene expression data for Chromophobe Renal Cell Carcinoma.

Pathways for genes affiliated with Chromophobe Renal Cell Carcinoma

Compounds for genes affiliated with Chromophobe Renal Cell Carcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6PVALB
2monochloroacetic acid4510.5VIM, KIT
3toluidine4510.5KIT, S100A1, VIM
4mucicarmine4510.4KRT7, VIM, S100A1
5b 7234510.4KRT7, S100A1, VIM
62-methoxyethanol4510.4S100A1, VIM
7hematoxylin4510.4KRT7, KIT, S100A1, VIM
8formaldehyde45 2411.3VIM, KIT, KRT7, PVALB
9methionine4510.3VIM, PVALB, MME, KIT
10cytarabine45 50 1112.2VIM, MME, KIT
11histamine45 29 2412.2VIM, PVALB, MME, KIT
12reticulin4510.2KRT7, VIM
13progesterone45 60 29 11 2414.1KRT7, KIT, MME, VIM, S100A1
14acetylcholine45 50 29 11 2414.1PVALB, MME, S100A1, VIM
15retinoic acid45 2411.1KRT7, VIM, HNF1B, S100A1, MME, KIT
16glycogen45 2411.0VIM, KIT, KRT7, S100A1
17paraffin459.9KRT7, MME, EPCAM, MAGEA3, KIT, S100A1
18oligonucleotide459.7KIT, MAGEA3, HNF1B, VIM, CLDN7

GO Terms for genes affiliated with Chromophobe Renal Cell Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:0059239.9CLDN7, CLDN8, EPCAM
2integral to membraneGO:0160219.4PRSS8, MAL2, CDH16, EPCAM, RNF139, CLDN8

Molecular functions related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.0KRT7, HNF1B, S100A1, FLCN, PRSS8, MAGEA3

Products for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources for Chromophobe Renal Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet