MCID: CHR177
MIFTS: 42

Chromophobe Renal Cell Carcinoma malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

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Sources:
30LifeMap Discovery®, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Chromophobe Renal Cell Carcinoma, Aliases & Descriptions:

Name: Chromophobe Renal Cell Carcinoma 30 41 47 60
Chromophobe Renal Cell Adenocarcinoma 47
 
Chrcc 41
Crcc 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Orphanet47 319303
ICD10 via Orphanet26 C64
UMLS via Orphanet61 C1266042

Summaries for Chromophobe Renal Cell Carcinoma

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NIH Rare Diseases:41 Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (rcc). chromophobe renal cell carcinoma makes up about 4-6% of rcc, and it is frequently diagnosed between ages 50 and 60. it is thought to have a more favorable prognosis than clear cell rcc, which is the main subtype of rcc. last updated: 11/2/2010

MalaCards based summary: Chromophobe Renal Cell Carcinoma, also known as chromophobe renal cell adenocarcinoma, is related to renal cell carcinoma and renal oncocytoma. An important gene associated with Chromophobe Renal Cell Carcinoma is PSMB9 (proteasome (prosome, macropain) subunit, beta type, 9), and among its related pathways are WNT Signaling and Presenilin-Mediated Signaling. The compound aprotinin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, uterus and kidney, and related mouse phenotype immune system.

Related Diseases for Chromophobe Renal Cell Carcinoma

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Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to chromophobe renal cell carcinoma

Symptoms for Chromophobe Renal Cell Carcinoma

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Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Chromophobe Renal Cell Carcinoma

Search NIH Clinical Center for Chromophobe Renal Cell Carcinoma

Genetic Tests for Chromophobe Renal Cell Carcinoma

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Anatomical Context for Chromophobe Renal Cell Carcinoma

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MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

31
Skeletal muscle, Uterus, Kidney, Bone, Bone marrow, Heart, Lung, Breast, Prostate, Testis, Myeloid, T cells, B cells, Liver, Lymph node, Colon, Thyroid

Animal Models for Chromophobe Renal Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Chromophobe Renal Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1HNF1B, PSMB9, PRSS8, MME, FLCN

Publications for Chromophobe Renal Cell Carcinoma

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Articles related to Chromophobe Renal Cell Carcinoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Eosinophilic variant of chromophobe renal cell carcinoma. (25552800)
2015
2
DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. (25596994)
2015
3
Clinical behavior of chromophobe renal cell carcinoma is less aggressive than that of clear cell renal cell carcinoma, independent of Fuhrman grade or tumor size. (25178561)
2014
4
Monocyte-derived dendritic cells reflect the immune functional status of a chromophobe renal cell carcinoma patient: Could it be a general phenomenon? (25314913)
2014
5
Predominantly tubular chromophobe renal cell carcinoma: an unusual histological presentation reminiscent of a neuroendocrine tumor. (23704098)
2013
6
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. (23953228)
2013
7
Interobserver reproducibility of a grading system for chromophobe renal cell carcinoma. (23058995)
2013
8
Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors. (23338778)
2013
9
Underexpression of hepatocyte nuclear factor-1I^ in chromophobe renal cell carcinoma. (23237209)
2013
10
Colon metastasis of chromophobe renal cell carcinoma with sarcomatoid change. (22964308)
2012
11
Chromophobe renal cell carcinoma with neuroendocrine differentiation and sarcomatoid change. (21884307)
2011
12
Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21: poorly differentiated form or "presarcomatoid" form? (21922389)
2011
13
Chromophobe renal cell carcinoma with prolonged response to sequential sunitinib and everolimus. (21245426)
2011
14
Two cases of eosinophilic variant chromophobe renal cell carcinoma, with a rare association of right atrial myxoma in one of them. (22219567)
2011
15
Temsirolimus in metastatic chromophobe renal cell carcinoma after interferon and sorafenib therapy. (21273619)
2011
16
Dedifferentiated chromophobe renal cell carcinoma with massive osteosarcoma-like divergent differentiation: a singular entity in the spectrum of retroperitoneal calcifying tumors. (19098016)
2010
17
Molecular pathology of chromophobe renal cell carcinoma: a review. (20590942)
2010
18
Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case. (20606735)
2010
19
MRI features of renal oncocytoma and chromophobe renal cell carcinoma. (21098174)
2010
20
Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. (20462447)
2010
21
Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. (20023267)
2010
22
Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? (20024582)
2010
23
Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. (19680475)
2009
24
A giant chromophobe renal cell carcinoma exceeding 10 kg. (20002842)
2009
25
Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (19302533)
2009
26
Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma. (20002769)
2009
27
Chromophobe renal cell carcinoma with neuroendocrine differentiation. (19024610)
2008
28
Chromophobe renal cell carcinoma with calcification: Report of a case with rare finding on aspiration smears. (18677748)
2008
29
Words of wisdom. Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (19051381)
2008
30
Chromophobe renal cell carcinoma in a child: case report and review of the literature. (17378685)
2007
31
Simultaneous occurrence of metastasizing carcinoid tumour of the gallbladder and chromophobe renal cell carcinoma in a young man. (18330096)
2007
32
Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: a case report. (17669599)
2007
33
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16927643)
2006
34
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
35
KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. (15832088)
2005
36
Toluidine positivity in chromophobe renal cell carcinoma: use in intraoperative diagnosis. (16242003)
2005
37
Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. (16337860)
2005
38
Chromophobe renal cell carcinoma: analysis of 61 cases. (15042674)
2004
39
Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (14702167)
2004
40
Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. (15198361)
2004
41
Chromophobe renal cell carcinoma showing oncocytoma-like hyalinized and edematous stroma: A case report and review of the literature. (15610861)
2004
42
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. (12507296)
2003
43
Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12352424)
2002
44
FISH analysis in chromophobe renal-cell carcinoma. (10613963)
2000
45
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000
46
Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma. (10765081)
2000
47
Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma: comparison of cytomorphologic features. (10385448)
1999
48
Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. (9844591)
1998
49
A case of chromophobe renal cell carcinoma with sarcomatoid foci and a small daughter lesion. (9788266)
1998
50
Aggressive variants of chromophobe renal cell carcinoma. (8859189)
1996

Variations for Chromophobe Renal Cell Carcinoma

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Expression for genes affiliated with Chromophobe Renal Cell Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Chromophobe Renal Cell Carcinoma patients vs. healthy controls: 30 (show all 35)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1IFIT3interferon-induced protein with tetratricopeptide repeats 3Skeletal Muscle+5.580.000
2ISG15ISG15 ubiquitin-like modifierSkeletal Muscle+5.250.000
3XISTX inactive specific transcript (non-protein coding)Skeletal Muscle+5.140.000
4RSAD2radical S-adenosyl methionine domain containing 2Skeletal Muscle+4.940.000
5GBP1guanylate binding protein 1, interferon-inducibleSkeletal Muscle+4.880.000
6CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialSkeletal Muscle+4.610.000
7IFI44Linterferon-induced protein 44-likeSkeletal Muscle+4.420.000
8MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)Skeletal Muscle+4.400.000
9IFI44interferon-induced protein 44Skeletal Muscle+4.340.000
10IFIT2interferon-induced protein with tetratricopeptide repeats 2Skeletal Muscle+3.960.000
11IFI27interferon, alpha-inducible protein 27Skeletal Muscle+3.860.000
12CXCL11chemokine (C-X-C motif) ligand 11Skeletal Muscle+3.670.000
13RPS4Y1ribosomal protein S4, Y-linked 1Skeletal Muscle-3.570.000
14IFIT1interferon-induced protein with tetratricopeptide repeats 1Skeletal Muscle+3.570.000
15MYH3myosin, heavy chain 3, skeletal muscle, embryonicSkeletal Muscle+3.540.000
16SAMHD1SAM domain and HD domain 1Skeletal Muscle+3.520.000
17XAF1XIAP associated factor 1Skeletal Muscle+3.440.000
18KLHDC7Bkelch domain containing 7BSkeletal Muscle+3.440.000
19IFI6interferon, alpha-inducible protein 6Skeletal Muscle+3.430.000
20IFIH1interferon induced with helicase C domain 1Skeletal Muscle+3.430.000
21PARP12poly (ADP-ribose) polymerase family, member 12Skeletal Muscle+3.410.000
22IFI16interferon, gamma-inducible protein 16Skeletal Muscle+3.400.000
23PLSCR1phospholipid scramblase 1Skeletal Muscle+3.370.000
24STAT1signal transducer and activator of transcription 1, 91kDaSkeletal Muscle+3.370.000
25PSMB8proteasome (prosome, macropain) subunit, beta type, 8Skeletal Muscle+3.350.000
26NNMTnicotinamide N-methyltransferaseSkeletal Muscle+3.310.000
27TRIM22tripartite motif containing 22Skeletal Muscle+3.270.000
28DTX3Ldeltex 3 like, E3 ubiquitin ligaseSkeletal Muscle+3.230.000
29EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 2Skeletal Muscle+3.140.000
30IRF7interferon regulatory factor 7Skeletal Muscle+3.130.000
31OAS12'-5'-oligoadenylate synthetase 1, 40/46kDaSkeletal Muscle+3.090.000
32IFITM1interferon induced transmembrane protein 1Skeletal Muscle+3.060.000
33TNFSF10tumor necrosis factor (ligand) superfamily, member 10Skeletal Muscle+3.050.000
34PARP9poly (ADP-ribose) polymerase family, member 9Skeletal Muscle+3.050.000
35POSTNperiostin, osteoblast specific factorSkeletal Muscle+3.030.000

Search GEO for disease gene expression data for Chromophobe Renal Cell Carcinoma.

Pathways for genes affiliated with Chromophobe Renal Cell Carcinoma

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Pathways related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH16, PSMB9
29.6CDH16, PSMB9

Compounds for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources:
43Novoseek, 12DrugBank
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Compounds related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1aprotinin43 1210.5PRSS8, MME

GO Terms for genes affiliated with Chromophobe Renal Cell Carcinoma

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Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.7CDH16, PRSS8, MME, FLCN, CLDN8

Biological processes related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:00018229.4HNF1B, MME

Products for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources for Chromophobe Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet