CRCC
MCID: CHR177
MIFTS: 37

Chromophobe Renal Cell Carcinoma (CRCC) malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Summaries for Chromophobe Renal Cell Carcinoma

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Chromophobe renal cell carcinoma is a subtype of the most common form of kidney cancer called renal cell carcinoma (rcc). chromophobe renal cell carcinoma makes up about 4-6% of rcc, and it is frequently diagnosed between ages 50 and 60. it is thought to have a more favorable prognosis than clear cell rcc, which is the main subtype of rcc. last updated: 11/2/2010

MalaCards: Chromophobe Renal Cell Carcinoma, also known as chromophobe renal cell adenocarcinoma, is related to renal oncocytoma and renal cell carcinoma. An important gene associated with Chromophobe Renal Cell Carcinoma is PSMB9 (proteasome (prosome, macropain) subunit, beta type, 9), and among its related pathways are WNT Signaling and Presenilin-Mediated Signaling. The compound aprotinin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow, and related mouse phenotype immune system.

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

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44NIH Rare Diseases, 50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

chromophobe renal cell carcinoma 44 50 63
chromophobe renal cell adenocarcinoma 50
chrcc 44
crcc 44


External Ids:

SNOMED-CT via Orphanet60 128667008
UMLS via Orphanet64 C1266042
ICD10 via Orphanet27 C64

Related Diseases for Chromophobe Renal Cell Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to chromophobe renal cell carcinoma

Symptoms for Chromophobe Renal Cell Carcinoma

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Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Chromophobe Renal Cell Carcinoma

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Anatomical Context for Chromophobe Renal Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

34
Kidney, Liver, Bone marrow, Bone, Lymph node, Colon, Thyroid

Animal Models for Chromophobe Renal Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chromophobe Renal Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1HNF1B, PSMB9, PRSS8, MME, FLCN

Publications for Chromophobe Renal Cell Carcinoma

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53PubMed
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Articles related to Chromophobe Renal Cell Carcinoma:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Predominantly tubular chromophobe renal cell carcinoma: an unusual histological presentation reminiscent of a neuroendocrine tumor. (23704098)
2013
2
Interobserver reproducibility of a grading system for chromophobe renal cell carcinoma. (23058995)
2013
3
Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors. (23338778)
2013
4
Underexpression of hepatocyte nuclear factor-1I^ in chromophobe renal cell carcinoma. (23237209)
2013
5
Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients. (23370773)
2013
6
Colon metastasis of chromophobe renal cell carcinoma with sarcomatoid change. (22964308)
2012
7
Chromophobe renal cell carcinoma with neuroendocrine differentiation and sarcomatoid change. (21884307)
2011
8
Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21: poorly differentiated form or "presarcomatoid" form? (21922389)
2011
9
Chromophobe renal cell carcinoma with prolonged response to sequential sunitinib and everolimus. (21245426)
2011
10
Two cases of eosinophilic variant chromophobe renal cell carcinoma, with a rare association of right atrial myxoma in one of them. (22219567)
2011
11
Temsirolimus in metastatic chromophobe renal cell carcinoma after interferon and sorafenib therapy. (21273619)
2011
12
Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. (21379425)
2011
13
Dedifferentiated chromophobe renal cell carcinoma with massive osteosarcoma-like divergent differentiation: a singular entity in the spectrum of retroperitoneal calcifying tumors. (19098016)
2010
14
Molecular pathology of chromophobe renal cell carcinoma: a review. (20590942)
2010
15
Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case. (20606735)
2010
16
MRI features of renal oncocytoma and chromophobe renal cell carcinoma. (21098174)
2010
17
Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. (20462447)
2010
18
Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. (20023267)
2010
19
Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? (20024582)
2010
20
Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. (19680475)
2009
21
A giant chromophobe renal cell carcinoma exceeding 10 kg. (20002842)
2009
22
Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (19302533)
2009
23
Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma. (20002769)
2009
24
CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. (19386349)
2009
25
Chromophobe renal cell carcinoma with neuroendocrine differentiation. (19024610)
2008
26
Chromophobe renal cell carcinoma with calcification: Report of a case with rare finding on aspiration smears. (18677748)
2008
27
Words of wisdom. Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (19051381)
2008
28
Chromophobe renal cell carcinoma presenting as hemorrhagic shock: case report. (18814820)
2008
29
Chromophobe renal cell carcinoma in a child: case report and review of the literature. (17378685)
2007
30
Simultaneous occurrence of metastasizing carcinoid tumour of the gallbladder and chromophobe renal cell carcinoma in a young man. (18330096)
2007
31
Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: a case report. (17669599)
2007
32
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16927643)
2006
33
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
34
KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. (15832088)
2005
35
Toluidine positivity in chromophobe renal cell carcinoma: use in intraoperative diagnosis. (16242003)
2005
36
Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. (16337860)
2005
37
Chromophobe renal cell carcinoma: analysis of 61 cases. (15042674)
2004
38
Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (14702167)
2004
39
Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. (15198361)
2004
40
Chromophobe renal cell carcinoma showing oncocytoma-like hyalinized and edematous stroma: A case report and review of the literature. (15610861)
2004
41
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. (12507296)
2003
42
Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12352424)
2002
43
FISH analysis in chromophobe renal-cell carcinoma. (10613963)
2000
44
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000
45
Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma. (10765081)
2000
46
Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma: comparison of cytomorphologic features. (10385448)
1999
47
Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. (9844591)
1998
48
A case of chromophobe renal cell carcinoma with sarcomatoid foci and a small daughter lesion. (9788266)
1998
49
Chromophobe renal cell carcinoma: clinicopathological study of 7 cases. (9491212)
1998
50
Aggressive variants of chromophobe renal cell carcinoma. (8859189)
1996

Variations for Chromophobe Renal Cell Carcinoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Chromophobe Renal Cell Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.92G> A (p.Gly31Asp)single nucleotide variantPathogenicrs137853247GRCh37Chr 12, 121416663: 121416663

Expression for genes affiliated with Chromophobe Renal Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chromophobe Renal Cell Carcinoma

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Pathways for genes affiliated with Chromophobe Renal Cell Carcinoma

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51PathCards, 54QIAGEN
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Pathways related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH16, PSMB9
29.6CDH16, PSMB9

Compounds for genes affiliated with Chromophobe Renal Cell Carcinoma

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46Novoseek, 12DrugBank
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Compounds related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aprotinin46 1210.5PRSS8, MME

GO Terms for genes affiliated with Chromophobe Renal Cell Carcinoma

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17Gene Ontology
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Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7CDH16, PRSS8, MME, FLCN, CLDN8

Biological processes related to Chromophobe Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.4HNF1B, MME

Products for genes affiliated with Chromophobe Renal Cell Carcinoma

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Sources for Chromophobe Renal Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet