MCID: CHR247
MIFTS: 18

Chromosome 4p Deletion malady

Category: Rare diseases

Aliases & Classifications for Chromosome 4p Deletion

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Aliases & Descriptions for Chromosome 4p Deletion:

Name: Chromosome 4p Deletion 45
Partial Monosomy 4p 45 24
Chromosome 4 Short Arm Deletion 65
Wolf-Hirschhorn Syndrome 65
 
Deletion 4p 45
4p Monosomy 45
Monosomy 4p 45
4p Deletion 45

Classifications:



External Ids:

UMLS65 C2931557

Summaries for Chromosome 4p Deletion

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NIH Rare Diseases:45 Chromosome 4p deletion is a chromosome abnormality that occurs when there is a missing copy of the genetic material located on the short arm (p) of chromosome 4. the severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved. features that often occur in people with chromosome 4p deletion include developmental delay, intellectual disability, behavioral problems, and distinctive facial features. most cases are not inherited, but people can pass the deletion on to their children. treatment is based on the signs and symptoms present in each person. last updated: 6/29/2015

MalaCards based summary: Chromosome 4p Deletion, also known as partial monosomy 4p, is related to wolf-hirschhorn syndrome and alzheimer disease. An important gene associated with Chromosome 4p Deletion is WFS1 (Wolframin ER Transmembrane Glycoprotein). Affiliated tissues include lung.

Related Diseases for Chromosome 4p Deletion

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Diseases related to Chromosome 4p Deletion via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1wolf-hirschhorn syndrome11.6
2alzheimer disease10.2
3leiomyosarcoma10.2
4thrombophlebitis10.2
5lung leiomyosarcoma10.2
6neuronitis10.2

Graphical network of diseases related to Chromosome 4p Deletion:



Diseases related to chromosome 4p deletion

Symptoms for Chromosome 4p Deletion

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Drugs & Therapeutics for Chromosome 4p Deletion

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Chromosome 4p Deletion

Genetic Tests for Chromosome 4p Deletion

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Anatomical Context for Chromosome 4p Deletion

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MalaCards organs/tissues related to Chromosome 4p Deletion:

33
Lung

Animal Models for Chromosome 4p Deletion or affiliated genes

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Publications for Chromosome 4p Deletion

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Articles related to Chromosome 4p Deletion:

idTitleAuthorsYear
1
The WNT inhibitor APCDD1 sustains the expression of I^-catenin during the osteogenic differentiation of human dental follicle cells. (25592970)
2015
2
Angiogenic response to major lung resection for non-small cell lung cancer with video-assisted thoracic surgical and open access. (23024612)
2012
3
A first step in bringing typhoid fever out of the closet. (22371964)
2012
4
Salivary duct carcinoma with neuroendocrine features: report of a case with cytological and immunohistochemical study. (15349992)
2004
5
Immunological effects of flavone acetic acid. (2208107)
1990

Variations for Chromosome 4p Deletion

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Expression for genes affiliated with Chromosome 4p Deletion

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Search GEO for disease gene expression data for Chromosome 4p Deletion.

Pathways for genes affiliated with Chromosome 4p Deletion

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GO Terms for genes affiliated with Chromosome 4p Deletion

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Sources for Chromosome 4p Deletion

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet