CEBV
MCID: CHR276
MIFTS: 44

Chronic Active Epstein-Barr Virus Infection (CEBV) malady

Rare diseases category

Summaries for Chronic Active Epstein-Barr Virus Infection

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34MalaCards
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MalaCards: Chronic Active Epstein-Barr Virus Infection, also known as chronic active epstein-barr disease, is related to leukemia and arthritis. An important gene associated with Chronic Active Epstein-Barr Virus Infection is ATR (ataxia telangiectasia and Rad3 related), and among its related pathways are OX40 Pathway and Cytokine Network. The compounds interferon gamma and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Chronic Active Epstein-Barr Virus Infection

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

chronic active epstein-barr virus infection 44
chronic active epstein-barr disease 44
caebv infection 44
cebv 44


Related Diseases for Chronic Active Epstein-Barr Virus Infection

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18GeneCards, 19GeneDecks
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Diseases related to Chronic Active Epstein-Barr Virus Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.7LAIR1, TGFB1, IL2, TRD, TRG
2arthritis30.6IL10, TGFB1, TNFAIP6
3inflammatory bowel disease30.5IL10, IL2, TGFB1
4rheumatoid arthritis30.5TNFAIP6, IL2, IL10, TRD, TRG
5hematopoietic stem cell transplantation10.7
6hemophagocytic lymphohistiocytosis10.6
7encephalitis10.6
8hepatitis10.6
9histiocytosis10.6
10myocarditis10.6
11vasculitis10.6
12hydroa vacciniforme10.6
13large granular lymphocyte leukemia10.6
14polymyositis10.6
15virus associated hemophagocytic syndrome10.6
16aneurysm10.6
17rheumatic fever10.4
18langerhans-cell histiocytosis10.4
19cryoglobulinemia10.4
20chediak-higashi syndrome10.4
21autoimmune lymphoproliferative syndrome10.4
22autoimmune hepatitis10.4
23infectious mononucleosis10.4
24malignant histiocytosis10.4
25chronic fatigue syndrome10.4
26coronary aneurysm10.4
27systemic lupus erythematosus10.4
28adult-onset still's disease10.4
29kawasaki disease10.4
30cerebellar ataxia10.4
31glomerulonephritis10.4
32hodgkin's lymphoma10.4
33hypertension10.4
34lupus erythematosus10.4
35myositis10.4
36purpura10.4
37uveitis10.4
38b-cell lymphomas10.4
39coronary artery aneurysm10.4
40hypereosinophilic syndrome10.4
41lymphomatoid granulomatosis10.4
42myelodysplastic syndromes10.4
43ataxia10.4
44hiv-110.4
45leprosy10.1IL2
46hepatitis b10.0IL10, TGFB1
47mycosis fungoides10.0TRG, IL2
48lupus nephritis10.0IL10, TGFB1
49cutaneous t cell lymphoma10.0TRG, IL2
50skin disease10.0IL2, TGFB1

Graphical network of the top 20 diseases related to Chronic Active Epstein-Barr Virus Infection:



Diseases related to chronic active epstein-barr virus infection

Symptoms for Chronic Active Epstein-Barr Virus Infection

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Drugs & Therapeutics for Chronic Active Epstein-Barr Virus Infection

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Drug clinical trials:

Search ClinicalTrials for Chronic Active Epstein-Barr Virus Infection

Search NIH Clinical Center for Chronic Active Epstein-Barr Virus Infection

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Genetic Tests for Chronic Active Epstein-Barr Virus Infection

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Anatomical Context for Chronic Active Epstein-Barr Virus Infection

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34MalaCards
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MalaCards organs/tissues related to Chronic Active Epstein-Barr Virus Infection:

34
T cells, Bone, Bone marrow, Nk cells, Skin, Liver, Colon, B cells

Animal Models for Chronic Active Epstein-Barr Virus Infection or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Active Epstein-Barr Virus Infection:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9ATR, TGFB1, IL2, IL10, TRD
2MP:00053708.9ATR, TGFB1, IL2, IL10, TRD
3MP:00053798.8IL10, IL2, TGFB1, TNFAIP6, ATR
4MP:00053898.6ATR, TNFAIP6, TGFB1, IL2, IL10
5MP:00107718.6ATR, TGFB1, IL10, TRD, TRG
6MP:00053888.4ATR, TNFAIP6, TGFB1, IL2, IL10, TRD
7MP:00053858.4ATR, TGFB1, IL2, IL10, TRD
8MP:00053818.3ATR, TGFB1, IL2, IL10, TRD, TRG
9MP:00053848.2ATR, TGFB1, IL2, IL10, TRD, TRG
10MP:00053768.1GBP5, ATR, TGFB1, IL2, IL10, TRD
11MP:00107687.9TRD, IL10, IL2, TGFB1, ATR, GBP1
12MP:00053977.4GBP5, ATR, LAIR1, TGFB1, IL2, IL10
13MP:00053876.0TRG, GBP1, GBP5, ATR, TNFAIP6, LAIR1

Publications for Chronic Active Epstein-Barr Virus Infection

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Sources:
53PubMed
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Articles related to Chronic Active Epstein-Barr Virus Infection:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. (23731478)
2013
2
Chronic active Epstein-Barr virus infection-associated hydroa vacciniforme-like eruption and BehAset's-like orogenital ulcers. (23751255)
2013
3
Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. (23687223)
2013
4
An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature. (22895834)
2013
5
Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation. (22466838)
2012
6
Quantification of Epstein-Barr virus DNA is helpful for evaluation of chronic active Epstein-Barr virus infection. (22850617)
2012
7
An adult case of chronic active Epstein-Barr virus infection with interstitial pneumonitis. (22205850)
2011
8
Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis. (21491104)
2011
9
Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. (21245635)
2011
10
Chronic active Epstein-Barr virus infection mimicking Henoch-SchAPnlein purpura. (21245820)
2010
11
A case of unilateral optic disc swelling with chronic active Epstein-Barr virus infection. (20856592)
2010
12
Chronic active Epstein-Barr virus infection with mosquito allergy successfully treated with reduced-intensity unrelated allogeneic bone marrow transplantation in a boy. (18627511)
2009
13
Cardiovascular complications associated with chronic active Epstein-Barr virus infection. (19184184)
2009
14
Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. (18260761)
2008
15
Clinical and virological characteristics of patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation: insights and questions. (18419487)
2008
16
Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection. (18833029)
2008
17
An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions. (18793782)
2008
18
Active myocarditis in a patient with chronic active Epstein-Barr virus infection. (17913266)
2008
19
Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (17474115)
2008
20
Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? (16791843)
2006
21
Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. (17168991)
2006
22
Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection. (16825143)
2006
23
Increased intracranial pressure due to chronic active Epstein-Barr virus infection. (17074607)
2006
24
Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease. (15750464)
2005
25
Guillain-BarrAc syndrome and hemophagocytic lymphohistiocytosis in a patient with severe chronic active Epstein-Barr virus infection syndrome. (16311154)
2005
26
Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. (16138335)
2005
27
Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation. (14576041)
2004
28
A case of a long-time survivor with chronic active Epstein-Barr virus infection. (14962269)
2004
29
Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis. (15075999)
2004
30
Complete resolution of severe chronic active Epstein-Barr virus infection by cultured, activated donor T lymphocyte infusion after nonmyeloablative stem cells allografting. (12815486)
2003
31
Natural killer cell-type body cavity lymphoma following chronic active Epstein-Barr virus infection. (12749015)
2003
32
Polyclonal proliferation of lymphocytes containing the epstein-barr virus genome in a patient dying of myocarditis in chronic active Epstein-Barr virus infection. (12544781)
2003
33
Overview and problematic standpoints of severe chronic active Epstein-Barr virus infection syndrome. (12467967)
2002
34
A possible mechanism of NK cell-lineage granular lymphocyte proliferative disorder (NK-GLPD) in a patient with chronic active Epstein-Barr virus infection (CAEBV) and severe hypersensitivity to mosquito bites (SHMB). (12211536)
2002
35
Presence of natural killer-cell clones with variable proliferative capacity in chronic active Epstein-Barr virus infection. (11881730)
2001
36
Chronic, active Epstein-Barr virus infection. (10608506)
2000
37
Calcification in the basal ganglia with chronic active Epstein-Barr virus infection. (9596016)
1998
38
Clonal lymphoproliferation following chronic active Epstein-Barr virus infection and hypersensitivity to mosquito bites. (9092681)
1997
39
Disseminated nasal T cell lymphoma with a partial deletion of the LMP1 oncogene in a patient with chronic active Epstein-Barr virus infection. (7658730)
1995
40
Chronic active Epstein-Barr virus infection in children in Japan. (8580625)
1995
41
Ganciclovir for chronic active Epstein-Barr virus infection. (8094799)
1993
42
Severe chronic active Epstein-Barr virus infection syndrome. (1848476)
1991
43
Severe chronic active Epstein-Barr virus infection syndrome and adenovirus type-2 infection. (2165745)
1990
44
Adenovirus type-2 in a patient with lethal hemorrhagic colonic ulcers and chronic active Epstein-Barr virus infection. (2833864)
1988
45
Encephalitis in association with chronic active Epstein-Barr virus infection. (2848861)
1988
46
Remarkable depression of CD4+2H4+ T cells in severe chronic active Epstein-Barr virus infection. (2827299)
1987
47
Chronic active Epstein-Barr virus infection in patients with Chediak-Higashi syndrome. (3018035)
1986
48
Immune function in chronic active Epstein-Barr virus infection. (2579970)
1985
49
Heterogeneity of immune defects in three children with a chronic active Epstein-Barr virus infection. (3878848)
1985
50
Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis). (2984282)
1985

Variations for Chronic Active Epstein-Barr Virus Infection

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Expression for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Search GEO for disease gene expression data for Chronic Active Epstein-Barr Virus Infection.

Pathways for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 55R&D Systems
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Pathways related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2, IL10
29.8IL10, IL2
3
Show member pathways
9.8TGFB1, ATR
49.8IL10, TGFB1
59.8IL2, TGFB1
69.8IL2, TGFB1
79.8TGFB1, IL2
89.5ATR, TGFB1, IL2
9
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.4IL10, IL2, TGFB1
10
Show member pathways
9.4IL10, IL2, TGFB1
119.4IL10, IL2, TGFB1
12
Show member pathways
IL27-mediated signaling events39
9.4TGFB1, IL2, IL10
13
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4IL10, IL2, TGFB1
14
Show member pathways
9.4IL10, IL2, TGFB1
15
Show member pathways
9.4TGFB1, IL2, IL10
16
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
17
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
18
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
19
Show member pathways
8.8IL2, GBP5, GBP1
20
Show member pathways
8.6IL10, IL2, TGFB1, TNFAIP6, ATR

Compounds for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1interferon gamma4610.2IL10, IL2
2alpha-galactosylceramide4610.2IL10, IL2
3toxin-14610.2IL2, IL10
4glatiramer acetate46 1211.2IL10, IL2
5as 10146 6211.2IL2, IL10
6il-124610.1IL2, IL10
7okt34610.1IL10, IL2
8pirfenidone46 6211.1TGFB1, IL2
9con a4610.1IL10, IL2
10polyinosinic-polycytidylic acid4610.1IL10, IL2
112,5-oligoadenylate4610.1IL10, IL2
12mycophenolate mofetil46 52 1212.1IL2, IL10
13cimetidine46 30 1212.0IL10, IL2
14ribavirin46 52 1212.0IL10, IL2
15pentoxifylline46 1211.0IL10, IL2
16ifn-alpha4610.0IL2, IL10
17betacarotene469.9IL10, TGFB1
18neopterin469.9IL2, IL10
19gm-csf46 3010.8IL10, IL2, TGFB1
20il 10469.8TGFB1, IL2, IL10
21rituximab46 52 1211.8IL10, IL2, TGFB1
22zidovudine46 52 1211.8TGFB1, IL2, IL10
23tacrolimus46 52 1211.8TGFB1, IL2, IL10
24dmso469.8IL10, IL2, TGFB1
25calcitriol46 62 25 1212.8IL10, IL2, TGFB1
264-hydroxynonenal46 2510.8IL10, TGFB1
27neomycin469.8IL2, TGFB1
28rantes469.8IL10, IL2, TGFB1
29histamine46 30 2511.7TGFB1, IL2, IL10
30cyclosporin a46 30 6211.7TGFB1, IL2, IL10
31theophylline46 30 25 1212.5IL10, TGFB1
32thymidine46 2510.3TGFB1, IL2, IL10
33pge2469.3TNFAIP6, TGFB1, IL2, IL10
34dexamethasone46 52 30 1212.2IL10, IL2, TGFB1, TNFAIP6

GO Terms for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources:
17Gene Ontology
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Biological processes related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of DNA replicationGO:0081569.9TGFB1, ATR
2positive regulation of interleukin-17 productionGO:0327409.9IL2, TGFB1
3negative regulation of T cell proliferationGO:0421309.8TGFB1, IL10
4negative regulation of protein phosphorylationGO:0019339.7IL2, TGFB1
5cell-cell signalingGO:0072679.4IL10, IL2, TNFAIP6
6inflammatory responseGO:0069549.3IL10, TGFB1, TNFAIP6
7response to drugGO:0424939.2IL10, TGFB1, ATR

Molecular functions related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.4IL10, IL2, TGFB1

Products for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources for Chronic Active Epstein-Barr Virus Infection

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet