CEBV
MCID: CHR276
MIFTS: 32

Chronic Active Epstein-Barr Virus Infection (CEBV) malady

Summaries for Chronic Active Epstein-Barr Virus Infection

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32MalaCards
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MalaCards: Chronic Active Epstein-Barr Virus Infection, also known as chronic active epstein-barr disease, is related to leukemia and glomerulonephritis. An important gene associated with Chronic Active Epstein-Barr Virus Infection is IDO1 (indoleamine 2,3-dioxygenase 1), and among its related pathways are Rho Family GTPases and Spinal Cord Injury. The compounds gm-csf and 1-methyltryptophan have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Chronic Active Epstein-Barr Virus Infection

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42NIH Rare Diseases
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Aliases & Descriptions:

chronic active epstein-barr virus infection 42
chronic active epstein-barr disease 42
caebv infection 42
cebv 42


Related Diseases for Chronic Active Epstein-Barr Virus Infection

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17GeneCards, 18GeneDecks
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Diseases related to Chronic Active Epstein-Barr Virus Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.7IDO1, IFNG, TRD, TRG, IL2, LAIR1
2glomerulonephritis30.6TGFB1
3uveitis30.5IL10, IFNG
4inflammatory bowel disease30.5TGFB1, IL2, IL10
5arthritis30.5IDO1, IFNG, TNFAIP6, IL10, TGFB1
6rheumatoid arthritis30.5IDO1, IFNG, TNFAIP6, TRD, TRG, IL10
7hemophagocytic lymphohistiocytosis10.5
8epstein-barr virus hepatitis10.5
9coronary aneurysm10.5
10chronic lymphocytic leukemia10.5
11encephalitis10.5
12hepatitis10.5
13histiocytosis10.5
14myocarditis10.5
15vasculitis10.5
16coronary artery disease10.4
17autoimmune lymphoproliferative syndrome10.4
18chediak-higashi syndrome10.4
19cryoglobulinemia10.4
20rheumatic fever10.4
21systemic lupus erythematosus10.4
22autoimmune hepatitis10.4
23infectious mononucleosis10.4
24malignant histiocytosis10.4
25chronic fatigue syndrome10.4
26adult syndrome10.4
27kawasaki disease10.4
28adult-onset still's disease10.4
29aneurysm disease10.4
30aortic aneurysm10.4
31aortic disease10.4
32cerebellar ataxia10.4
33hodgkin's lymphoma10.4
34hypersensitivity vasculitis10.4
35hypertension10.4
36langerhans-cell histiocytosis10.4
37lupus erythematosus10.4
38myositis10.4
39purpura10.4
40eosinophilia-myalgia syndrome10.0IDO1
41endometriosis10.0IDO1
42herpes simplex10.0IDO1
43astrocytoma10.0IDO1
44leprosy10.0IL2
45thrombocytopenia10.0IL2
46vaccinia10.0IL2
47acquired immunodeficiency syndrome10.0IL2
48biliary atresia10.0TGFB1
49myeloid leukemia10.0TGFB1
50listeriosis10.0IDO1

Graphical network of the top 20 diseases related to Chronic Active Epstein-Barr Virus Infection:



Diseases related to chronic active epstein-barr virus infection

Clinical Features for Chronic Active Epstein-Barr Virus Infection

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Drugs & Therapeutics for Chronic Active Epstein-Barr Virus Infection

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Drug clinical trials:

Search ClinicalTrials for Chronic Active Epstein-Barr Virus Infection

Search NIH Clinical Center for Chronic Active Epstein-Barr Virus Infection

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Genetic Tests for Chronic Active Epstein-Barr Virus Infection

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Anatomical Context for Chronic Active Epstein-Barr Virus Infection

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Animal Models for Chronic Active Epstein-Barr Virus Infection or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Active Epstein-Barr Virus Infection:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3IFNG, IL2, TGFB1
2MP:00020068.2IFNG, ATR, TRD, IL10, IL2, TGFB1
3MP:00053708.2IFNG, ATR, TRD, IL10, IL2, TGFB1
4MP:00053888.1IFNG, ATR, TRD, IL10, IL2, TGFB1
5MP:00053898.1IDO1, IFNG, TNFAIP6, ATR, IL10, IL2
6MP:00053858.0TGFB1, IL2, IL10, TRD, ATR, IFNG
7MP:00053817.7IFNG, ATR, TRD, TRG, IL10, IL2
8MP:00107717.5IFNG, ATR, TRD, TRG, IL10, TGFB1
9MP:00053767.3IDO1, IFNG, ATR, TRD, GBP5, IL10
10MP:00053847.3IDO1, IFNG, ATR, TRD, TRG, IL10
11MP:00053977.1IDO1, IFNG, ATR, TRD, TRG, IL10
12MP:00053876.1TGFB1, IDO1, IFNG, ATR, TRD, TRG

Publications for Chronic Active Epstein-Barr Virus Infection

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Genetic Variations for Chronic Active Epstein-Barr Virus Infection

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Expression for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Search GEO for disease gene expression data for Chronic Active Epstein-Barr Virus Infection.

Pathways for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG, 52R&D Systems, 53Reactome
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Compounds for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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44Novoseek, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
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Compounds related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.2IL10, IFNG
21-methyltryptophan4410.2IFNG, IDO1
3betaseron4410.2IL10, IFNG
43-hydroxyanthranilic acid44 2411.1IDO1, IFNG
5toxin-14410.1IL2, IL10
6kynurenine4410.1IFNG, IDO1
7bucillamine4410.1IFNG, IL2
8taurine chloramine4410.1IL2, IFNG
9tranilast4410.1IFNG, TGFB1
10tuberculin4410.0IFNG, IL10
11gold sodium thiomalate4410.0IFNG, IL2
12auranofin44 59 28 1113.0IL2, IFNG
13natalizumab44 1111.0IL10, IFNG
14fumarate44 1110.9IFNG, IL2
15as 10159 4410.9IL2, IL10
16interferon gamma449.9IFNG, IL10, IL2
17alpha-galactosylceramide449.9IL2, IL10, IFNG
18infliximab44 49 1111.9IL10, IFNG, IDO1
19glatiramer acetate44 1110.9IFNG, IL10, IL2
20il-12449.9IL2, IL10, IFNG
21okt3449.9IFNG, IL10, IL2
22con a449.9IL2, IL10, IFNG
23polyinosinic-polycytidylic acid449.9IFNG, IL10, IL2
24mycophenolate mofetil44 49 1111.9IFNG, IL10, IL2
25ribavirin44 49 1111.8IFNG, IL10, IL2
26zidovudine44 1110.8IL10, IL2, TGFB1
27ifn-alpha449.8IL2, IL10, IFNG
28l-tryptophan44 28 11 2412.8IFNG, IDO1
29thalidomide44 49 59 1112.8IL2, IL10, IFNG
30adalimumab44 49 1111.8IFNG, IL10
312,5-oligoadenylate449.6IL2, IL10, IFNG, IDO1
32neopterin449.6IDO1, IFNG, IL10, IL2
33ionomycin449.6IL2, IL10, IFNG
34rantes449.6TGFB1, IL2, IFNG, IDO1
35il 10449.6TGFB1, IL2, IL10, IFNG
36tacrolimus44 49 1111.5TGFB1, IL2, IL10, IFNG
37calcitriol44 59 11 2412.5TGFB1, IL2, IL10, IFNG
38imiquimod44 28 59 1112.5IL10, IFNG
39histamine44 28 2411.5IFNG, IL10, IL2, TGFB1
40cyclosporin a44 28 5911.4IFNG, IL10, IL2, TGFB1
41dmso449.4TGFB1, IL2, IL10
42thymidine44 2410.3IDO1, IFNG, IL10, IL2, TGFB1
43pge2448.7IDO1, IFNG, TNFAIP6, IL10, IL2, TGFB1
44dexamethasone44 49 28 1111.7IDO1, IFNG, TNFAIP6, IL10, IL2, TGFB1

GO Terms for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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16Gene Ontology
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Biological processes related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.0IL2, IFNG
2positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IFNG
3positive regulation of interleukin-17 productionGO:03274010.0TGFB1, IL2
4negative regulation of growth of symbiont in hostGO:0441309.9IL10, IFNG
5negative regulation of DNA replicationGO:0081569.9ATR, TGFB1
6negative regulation of T cell proliferationGO:0421309.8TGFB1, IL10
7protein import into nucleus, translocationGO:0000609.8TGFB1, IFNG
8positive regulation of interleukin-12 productionGO:0327359.7IFNG, IDO1
9extrinsic apoptotic signaling pathwayGO:0971919.5TGFB1, IFNG

Molecular functions related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IL2, IL10, IFNG
2growth factor activityGO:0080839.2TGFB1, IL2, IL10

Products for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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  • Antibodies
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Sources for Chronic Active Epstein-Barr Virus Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet