MCID: CHR276
MIFTS: 37

Chronic Active Epstein-Barr Virus Infection malady

Rare diseases category

Aliases & Classifications for Chronic Active Epstein-Barr Virus Infection

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Chronic Active Epstein-Barr Virus Infection, Aliases & Descriptions:

Name: Chronic Active Epstein-Barr Virus Infection 41
Chronic Active Epstein-Barr Disease 41
 
Caebv Infection 41
Cebv 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Chronic Active Epstein-Barr Virus Infection

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MalaCards based summary: Chronic Active Epstein-Barr Virus Infection, also known as chronic active epstein-barr disease, is related to arthritis and inflammatory bowel disease. An important gene associated with Chronic Active Epstein-Barr Virus Infection is ATR (ataxia telangiectasia and Rad3 related), and among its related pathways are OX40 Pathway and Cytokine Network. The compounds interferon gamma and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include t cells, nk cells and bone marrow, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Chronic Active Epstein-Barr Virus Infection

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Diseases related to Chronic Active Epstein-Barr Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4IL10, TGFB1, TNFAIP6
2inflammatory bowel disease30.3IL10, IL2, TGFB1
3leukemia30.3LAIR1, TGFB1, IL2, TRD, TRG
4rheumatoid arthritis29.9TNFAIP6, IL2, IL10, TRD, TRG
5hematopoietic stem cell transplantation10.7
6hepatitis10.7
7hydroa vacciniforme10.7
8aneurysm10.7
9systemic lupus erythematosus10.6
10autoimmune hepatitis10.6
11hemophagocytic lymphohistiocytosis10.6
12encephalitis10.6
13histiocytosis10.6
14lupus erythematosus10.6
15myocarditis10.6
16vasculitis10.6
17large granular lymphocyte leukemia10.6
18polymyositis10.6
19virus associated hemophagocytic syndrome10.6
20chediak-higashi syndrome10.4
21myelodysplastic syndrome10.4
22autoimmune lymphoproliferative syndrome10.4
23kawasaki disease10.4
24hiv-110.4
25cerebellar ataxia10.4
26b-cell lymphomas10.4
27glomerulonephritis10.4
28lymphomatoid granulomatosis10.4
29rheumatic fever10.4
30langerhans-cell histiocytosis10.4
31cryoglobulinemia10.4
32malignant histiocytosis10.4
33chronic fatigue syndrome10.4
34coronary aneurysm10.4
35adult-onset still's disease10.4
36myositis10.4
37purpura10.4
38uveitis10.4
39coronary artery aneurysm10.4
40hypereosinophilic syndrome10.4
41ataxia10.4
42leprosy10.2IL2
43hepatitis b10.1IL10, TGFB1
44mycosis fungoides10.0TRG, IL2
45lupus nephritis10.0IL10, TGFB1
46cutaneous t cell lymphoma10.0TRG, IL2
47skin disease10.0IL2, TGFB1
48lepromatous leprosy10.0IL10, IL2
49acute graft versus host disease10.0IL10, IL2
50common variable immunodeficiency10.0IL10, IL2

Graphical network of the top 20 diseases related to Chronic Active Epstein-Barr Virus Infection:



Diseases related to chronic active epstein-barr virus infection

Symptoms for Chronic Active Epstein-Barr Virus Infection

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Drugs & Therapeutics for Chronic Active Epstein-Barr Virus Infection

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Drug clinical trials:

Search ClinicalTrials for Chronic Active Epstein-Barr Virus Infection

Search NIH Clinical Center for Chronic Active Epstein-Barr Virus Infection

Genetic Tests for Chronic Active Epstein-Barr Virus Infection

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Anatomical Context for Chronic Active Epstein-Barr Virus Infection

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MalaCards organs/tissues related to Chronic Active Epstein-Barr Virus Infection:

31
T cells, Nk cells, Bone marrow, Bone, Liver, Skin, Colon, B cells

Animal Models for Chronic Active Epstein-Barr Virus Infection or affiliated genes

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MGI Mouse Phenotypes related to Chronic Active Epstein-Barr Virus Infection:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9ATR, TGFB1, IL2, IL10, TRD
2MP:00053708.9ATR, TGFB1, IL2, IL10, TRD
3MP:00053798.8IL10, IL2, TGFB1, TNFAIP6, ATR
4MP:00053898.6ATR, TNFAIP6, TGFB1, IL2, IL10
5MP:00107718.6ATR, TGFB1, IL10, TRD, TRG
6MP:00053888.4ATR, TNFAIP6, TGFB1, IL2, IL10, TRD
7MP:00053858.4ATR, TGFB1, IL2, IL10, TRD
8MP:00053818.3ATR, TGFB1, IL2, IL10, TRD, TRG
9MP:00053848.2ATR, TGFB1, IL2, IL10, TRD, TRG
10MP:00053768.1GBP5, ATR, TGFB1, IL2, IL10, TRD
11MP:00107687.9TRD, IL10, IL2, TGFB1, ATR, GBP1
12MP:00053977.4GBP5, ATR, LAIR1, TGFB1, IL2, IL10
13MP:00053876.0TRG, GBP1, GBP5, ATR, TNFAIP6, LAIR1

Publications for Chronic Active Epstein-Barr Virus Infection

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Articles related to Chronic Active Epstein-Barr Virus Infection:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Recurrence of chronic active Epstein-Barr virus infection presenting with myelopathy after umbilical cord blood transplantation. (25342015)
2014
2
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. (23731478)
2013
3
Chronic active Epstein-Barr virus infection-associated hydroa vacciniforme-like eruption and BehAset's-like orogenital ulcers. (23751255)
2013
4
Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. (23687223)
2013
5
An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature. (22895834)
2013
6
Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation. (22466838)
2012
7
Quantification of Epstein-Barr virus DNA is helpful for evaluation of chronic active Epstein-Barr virus infection. (22850617)
2012
8
An adult case of chronic active Epstein-Barr virus infection with interstitial pneumonitis. (22205850)
2011
9
Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis. (21491104)
2011
10
Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. (21245635)
2011
11
Chronic active Epstein-Barr virus infection mimicking Henoch-SchAPnlein purpura. (21245820)
2010
12
Chronic active Epstein-Barr virus infection with mosquito allergy successfully treated with reduced-intensity unrelated allogeneic bone marrow transplantation in a boy. (18627511)
2009
13
Cardiovascular complications associated with chronic active Epstein-Barr virus infection. (19184184)
2009
14
Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. (18260761)
2008
15
Clinical and virological characteristics of patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation: insights and questions. (18419487)
2008
16
Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection. (18833029)
2008
17
An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions. (18793782)
2008
18
Active myocarditis in a patient with chronic active Epstein-Barr virus infection. (17913266)
2008
19
Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (17474115)
2008
20
Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? (16791843)
2006
21
Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. (17168991)
2006
22
Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection. (16825143)
2006
23
Increased intracranial pressure due to chronic active Epstein-Barr virus infection. (17074607)
2006
24
Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease. (15750464)
2005
25
Guillain-BarrAc syndrome and hemophagocytic lymphohistiocytosis in a patient with severe chronic active Epstein-Barr virus infection syndrome. (16311154)
2005
26
Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. (16138335)
2005
27
Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation. (14576041)
2004
28
A case of a long-time survivor with chronic active Epstein-Barr virus infection. (14962269)
2004
29
Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis. (15075999)
2004
30
Complete resolution of severe chronic active Epstein-Barr virus infection by cultured, activated donor T lymphocyte infusion after nonmyeloablative stem cells allografting. (12815486)
2003
31
Natural killer cell-type body cavity lymphoma following chronic active Epstein-Barr virus infection. (12749015)
2003
32
Polyclonal proliferation of lymphocytes containing the epstein-barr virus genome in a patient dying of myocarditis in chronic active Epstein-Barr virus infection. (12544781)
2003
33
Overview and problematic standpoints of severe chronic active Epstein-Barr virus infection syndrome. (12467967)
2002
34
A possible mechanism of NK cell-lineage granular lymphocyte proliferative disorder (NK-GLPD) in a patient with chronic active Epstein-Barr virus infection (CAEBV) and severe hypersensitivity to mosquito bites (SHMB). (12211536)
2002
35
Presence of natural killer-cell clones with variable proliferative capacity in chronic active Epstein-Barr virus infection. (11881730)
2001
36
Chronic, active Epstein-Barr virus infection. (10608506)
2000
37
Calcification in the basal ganglia with chronic active Epstein-Barr virus infection. (9596016)
1998
38
Clonal lymphoproliferation following chronic active Epstein-Barr virus infection and hypersensitivity to mosquito bites. (9092681)
1997
39
Disseminated nasal T cell lymphoma with a partial deletion of the LMP1 oncogene in a patient with chronic active Epstein-Barr virus infection. (7658730)
1995
40
Chronic active Epstein-Barr virus infection in children in Japan. (8580625)
1995
41
Ganciclovir for chronic active Epstein-Barr virus infection. (8094799)
1993
42
Severe chronic active Epstein-Barr virus infection syndrome. (1848476)
1991
43
Severe chronic active Epstein-Barr virus infection syndrome and adenovirus type-2 infection. (2165745)
1990
44
Adenovirus type-2 in a patient with lethal hemorrhagic colonic ulcers and chronic active Epstein-Barr virus infection. (2833864)
1988
45
Encephalitis in association with chronic active Epstein-Barr virus infection. (2848861)
1988
46
Remarkable depression of CD4+2H4+ T cells in severe chronic active Epstein-Barr virus infection. (2827299)
1987
47
Chronic active Epstein-Barr virus infection in patients with Chediak-Higashi syndrome. (3018035)
1986
48
Immune function in chronic active Epstein-Barr virus infection. (2579970)
1985
49
Heterogeneity of immune defects in three children with a chronic active Epstein-Barr virus infection. (3878848)
1985
50
Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis). (2984282)
1985

Variations for Chronic Active Epstein-Barr Virus Infection

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Expression for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Search GEO for disease gene expression data for Chronic Active Epstein-Barr Virus Infection.

Pathways for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Pathways related to Chronic Active Epstein-Barr Virus Infection according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2, IL10
29.8IL10, IL2
3
Show member pathways
9.8TGFB1, ATR
49.8IL10, TGFB1
59.8IL2, TGFB1
69.8IL2, TGFB1
79.8TGFB1, IL2
89.5ATR, TGFB1, IL2
9
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.4IL10, IL2, TGFB1
10
Show member pathways
9.4IL10, IL2, TGFB1
119.4IL10, IL2, TGFB1
12
Show member pathways
IL27-mediated signaling events36
9.4TGFB1, IL2, IL10
13
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4IL10, IL2, TGFB1
14
Show member pathways
9.4IL10, IL2, TGFB1
15
Show member pathways
9.4TGFB1, IL2, IL10
16
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
17
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
18
Show member pathways
8.9TNFAIP6, TGFB1, IL2, IL10
19
Show member pathways
8.8IL2, GBP5, GBP1
20
Show member pathways
8.6IL10, IL2, TGFB1, TNFAIP6, ATR

Compounds for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Compounds related to Chronic Active Epstein-Barr Virus Infection according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1interferon gamma4310.2IL10, IL2
2alpha-galactosylceramide4310.2IL10, IL2
3toxin-14310.2IL2, IL10
4glatiramer acetate43 1211.2IL10, IL2
5as 10143 5911.2IL2, IL10
6il-124310.1IL2, IL10
7okt34310.1IL10, IL2
8pirfenidone43 5911.1TGFB1, IL2
9con a4310.1IL10, IL2
10polyinosinic-polycytidylic acid4310.1IL10, IL2
112,5-oligoadenylate4310.1IL10, IL2
12mycophenolate mofetil43 49 1212.1IL2, IL10
13cimetidine43 28 1212.0IL10, IL2
14ribavirin43 49 1212.0IL10, IL2
15pentoxifylline43 1211.0IL10, IL2
16ifn-alpha4310.0IL2, IL10
17betacarotene439.9IL10, TGFB1
18neopterin439.9IL2, IL10
19gm-csf43 2810.8IL10, IL2, TGFB1
20il 10439.8TGFB1, IL2, IL10
21rituximab43 49 1211.8IL10, IL2, TGFB1
22zidovudine43 49 1211.8TGFB1, IL2, IL10
23tacrolimus43 49 1211.8TGFB1, IL2, IL10
24dmso439.8IL10, IL2, TGFB1
25calcitriol43 59 24 1212.8IL10, IL2, TGFB1
264-hydroxynonenal43 2410.8IL10, TGFB1
27neomycin439.8IL2, TGFB1
28rantes439.8IL10, IL2, TGFB1
29histamine43 28 2411.7TGFB1, IL2, IL10
30cyclosporin a43 28 5911.7TGFB1, IL2, IL10
31theophylline43 28 24 1212.5IL10, TGFB1
32thymidine43 2410.3TGFB1, IL2, IL10
33pge2439.3TNFAIP6, TGFB1, IL2, IL10
34dexamethasone43 49 28 1212.2IL10, IL2, TGFB1, TNFAIP6

GO Terms for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Biological processes related to Chronic Active Epstein-Barr Virus Infection according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of DNA replicationGO:00081569.9TGFB1, ATR
2positive regulation of interleukin-17 productionGO:00327409.9IL2, TGFB1
3negative regulation of T cell proliferationGO:00421309.8TGFB1, IL10
4negative regulation of protein phosphorylationGO:00019339.7IL2, TGFB1
5cell-cell signalingGO:00072679.4IL10, IL2, TNFAIP6
6inflammatory responseGO:00069549.3IL10, TGFB1, TNFAIP6
7response to drugGO:00424939.2IL10, TGFB1, ATR

Molecular functions related to Chronic Active Epstein-Barr Virus Infection according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.4IL10, IL2, TGFB1

Products for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources for Chronic Active Epstein-Barr Virus Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet