CEBV
MCID: CHR276
MIFTS: 42

Chronic Active Epstein-Barr Virus Infection (CEBV) malady

Summaries for Chronic Active Epstein-Barr Virus Infection

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33MalaCards
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MalaCards: Chronic Active Epstein-Barr Virus Infection, also known as chronic active epstein-barr disease, is related to hepatitis c and hepatitis b. An important gene associated with Chronic Active Epstein-Barr Virus Infection is IDO1 (indoleamine 2,3-dioxygenase 1), and among its related pathways are Rho Family GTPases and Spinal Cord Injury. The compounds gm-csf and 1-methyltryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Chronic Active Epstein-Barr Virus Infection

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

chronic active epstein-barr virus infection 43
chronic active epstein-barr disease 43
caebv infection 43
cebv 43


Related Diseases for Chronic Active Epstein-Barr Virus Infection

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Active Epstein-Barr Virus Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.8IDO1, IFNG, IL10
2hepatitis b30.8TGFB1, IFNG, IL10
3uveitis30.6IL10, IFNG
4arthritis30.5IL10, TNFAIP6, IFNG, IDO1, TGFB1
5hematopoietic stem cell transplantation10.6
6hemophagocytic lymphohistiocytosis10.6
7epstein-barr virus hepatitis10.6
8hepatitis e10.6
9coronary aneurysm10.6
10hepatitis a10.6
11vasculitis10.6
12hydroa vacciniforme10.6
13polymyositis10.6
14hepatitis c virus10.6
15hepatitis b virus infection10.6
16coronary artery disease,10.4
17autoimmune lymphoproliferative syndrome10.4
18chediak-higashi syndrome10.4
19cryoglobulinemia10.4
20rheumatic fever10.4
21systemic lupus erythematosus10.4
22autoimmune hepatitis10.4
23infectious mononucleosis10.4
24malignant histiocytosis10.4
25chronic fatigue syndrome10.4
26adult syndrome10.4
27kawasaki disease10.4
28adult-onset still's disease10.4
29aneurysm disease10.4
30aortic aneurysm10.4
31aortic disease10.4
32leukemia, b-cell, chronic10.4
33coronary artery aneurysm10.4
34hypereosinophilic syndrome10.4
35lymphomatoid granulomatosis10.4
36guillain-barr� syndrome10.4
37ataxia10.4
38b-cell chronic lymphocytic leukemia10.4
39eosinophilia-myalgia syndrome10.0IDO1
40endometriosis10.0IDO1
41herpes simplex10.0IDO1
42astrocytoma10.0IDO1
43leprosy10.0IL2
44thrombocytopenia10.0IL2
45vaccinia10.0IL2
46acquired immunodeficiency syndrome10.0IL2
47biliary atresia10.0TGFB1
48myeloid leukemia10.0TGFB1
49listeriosis10.0IDO1
50eye disease10.0TGFB1

Graphical network of the top 20 diseases related to Chronic Active Epstein-Barr Virus Infection:



Diseases related to chronic active epstein-barr virus infection

Clinical Features for Chronic Active Epstein-Barr Virus Infection

Drugs & Therapeutics for Chronic Active Epstein-Barr Virus Infection

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Drug clinical trials:

Search ClinicalTrials for Chronic Active Epstein-Barr Virus Infection

Search NIH Clinical Center for Chronic Active Epstein-Barr Virus Infection

Search CenterWatch for Chronic Active Epstein-Barr Virus Infection

Genetic Tests for Chronic Active Epstein-Barr Virus Infection

Anatomical Context for Chronic Active Epstein-Barr Virus Infection

Sources:
33MalaCards
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MalaCards organs/tissues related to Chronic Active Epstein-Barr Virus Infection:

33
Skin, Liver, Bone marrow, Colon, Nk cells, T cells, B cells

Animal Models for Chronic Active Epstein-Barr Virus Infection or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chronic Active Epstein-Barr Virus Infection

Sources:
51PubMed
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Articles related to Chronic Active Epstein-Barr Virus Infection:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. (23687223)
2013
2
A case of chronic active Epstein-Barr virus infection mimicking adult-onset Still's disease. (22370999)
2013
3
Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistiocytosis. (22511310)
2012
4
Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis. (21491104)
2011
5
Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. (21245635)
2011
6
Aggressive large B-cell lymphoma in a systemic lupus erythematosus patient with chronic active Epstein-Barr virus infection: a case report. (22230415)
2011
7
Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection. (21697063)
2011
8
Chronic active Epstein-Barr virus infection mimicking Henoch-SchAPnlein purpura. (21245820)
2010
9
Cardiovascular complications associated with chronic active Epstein-Barr virus infection. (19184184)
2009
10
Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection. (19915947)
2009
11
An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions. (18793782)
2008
12
Severe degenerative change of multiple organs mediated by chronic active Epstein-Barr virus infection with infected T-cell expansion. (18427908)
2008
13
Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? (16791843)
2006
14
Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. (17168991)
2006
15
Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection. (16628581)
2006
16
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection. (16827800)
2006
17
Successful report of reduced-intensity stem cell transplantation from unrelated umbilical cord blood in a girl with chronic active Epstein-Barr virus infection. (16679925)
2006
18
Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation. (16247742)
2005
19
Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. (15655776)
2005
20
Vascular lesion in a patient of chronic active Epstein-Barr virus infection with hypersensitivity to mosquito bites: vasculitis induced by mosquito bite with the infiltration of nonneoplastic Epstein-Barr virus-positive cells and subsequent development of natural killer/T-cell lymphoma with angiodestruction. (15754300)
2005
21
A case of a long-time survivor with chronic active Epstein-Barr virus infection. (14962269)
2004
22
Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis. (15075999)
2004
23
Polyclonal proliferation of lymphocytes containing the epstein-barr virus genome in a patient dying of myocarditis in chronic active Epstein-Barr virus infection. (12544781)
2003
24
Prognostic factors for chronic active Epstein-Barr virus infection. (12599068)
2003
25
Severe chronic active Epstein-Barr virus infection associated with multiple necrotic lesions in the liver. (12699856)
2003
26
Overview and problematic standpoints of severe chronic active Epstein-Barr virus infection syndrome. (12467967)
2002
27
CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection. (12410578)
2002
28
Infiltrations of Epstein-Barr virus-carrying cells in granular lymphocyte-proliferative disorders corresponding to chronic active Epstein-Barr virus infection. (12217191)
2002
29
Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation. (11960276)
2002
30
Fatal cytotoxic T-cell proliferation in chronic active Epstein-Barr virus infection in childhood. (11863225)
2002
31
Presence of natural killer-cell clones with variable proliferative capacity in chronic active Epstein-Barr virus infection. (11881730)
2001
32
Vidarabine therapy for severe chronic active Epstein-Barr virus infection. (11464986)
2001
33
Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. (11435294)
2001
34
Marked swollen erythema of the face together with sicca syndrome as a sign for chronic active Epstein-Barr virus infection. (11122068)
2000
35
Analysis of IgG subclasses in chronic active Epstein-Barr virus infection. (10703229)
2000
36
Calcification in the basal ganglia with chronic active Epstein-Barr virus infection. (9596016)
1998
37
Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome. (9952337)
1998
38
Large-vessel arteritis associated with chronic active Epstein-Barr virus infection. (9485096)
1998
39
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. (9766697)
1998
40
Epstein-Barr virus (EBV)-induced CD30+ natural killer cell-type malignancy resembling malignant histiocytosis: malignant transformation in chronic active EBV infection associating hypogammaglobulinemia. (9211526)
1997
41
Viral interleukin-10 in chronic active Epstein-Barr virus infection. (9207376)
1997
42
Chronic active Epstein-Barr virus infection with giant coronary aneurysms. (8659448)
1996
43
Epstein-Barr virus (EBV)-carrying and -expressing T-cell lines established from severe chronic active EBV infection. (8608235)
1996
44
Disseminated nasal T cell lymphoma with a partial deletion of the LMP1 oncogene in a patient with chronic active Epstein-Barr virus infection. (7658730)
1995
45
Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection. (7894217)
1994
46
Recurrent upper respiratory infection, persistent paravertebral thoracolumbar muscle spasm, and fatigue associated with chronic active Epstein-Barr virus infection. (1650418)
1991
47
Dual infections of the immune system in patients with chronic active Epstein-Barr virus infection mimicking chronic fatigue syndrome. (1669350)
1991
48
Remarkable depression of CD4+2H4+ T cells in severe chronic active Epstein-Barr virus infection. (2827299)
1987
49
The "chronic, active Epstein-Barr virus infection" syndrome and primary fibromyalgia. (2823835)
1987
50
Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis). (2984282)
1985

Genetic Variations for Chronic Active Epstein-Barr Virus Infection

Expression for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Search GEO for disease gene expression data for Chronic Active Epstein-Barr Virus Infection.

Pathways for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Sources:
52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG, 53R&D Systems, 54Reactome
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Compounds for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB
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Compounds related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.2IL10, IFNG
21-methyltryptophan4510.2IFNG, IDO1
3betaseron4510.2IL10, IFNG
43-hydroxyanthranilic acid45 2411.1IDO1, IFNG
5toxin-14510.1IL2, IL10
6kynurenine4510.1IFNG, IDO1
7bucillamine4510.1IFNG, IL2
8taurine chloramine4510.1IL2, IFNG
9tranilast4510.1IFNG, TGFB1
10tuberculin4510.0IFNG, IL10
11gold sodium thiomalate4510.0IFNG, IL2
12auranofin45 60 29 1113.0IL2, IFNG
13natalizumab45 1111.0IL10, IFNG
14fumarate45 1110.9IFNG, IL2
15as 10160 4510.9IL2, IL10
16interferon gamma459.9IFNG, IL10, IL2
17alpha-galactosylceramide459.9IL2, IL10, IFNG
18infliximab45 50 1111.9IL10, IFNG, IDO1
19glatiramer acetate45 1110.9IFNG, IL10, IL2
20il-12459.9IL2, IL10, IFNG
21okt3459.9IFNG, IL10, IL2
22con a459.9IL2, IL10, IFNG
23polyinosinic-polycytidylic acid459.9IFNG, IL10, IL2
24mycophenolate mofetil45 50 1111.9IFNG, IL10, IL2
25ribavirin45 50 1111.8IFNG, IL10, IL2
26zidovudine45 1110.8IL10, IL2, TGFB1
27ifn-alpha459.8IL2, IL10, IFNG
28l-tryptophan45 29 11 2412.8IFNG, IDO1
29thalidomide45 50 60 1112.8IL2, IL10, IFNG
30adalimumab45 50 1111.8IFNG, IL10
312,5-oligoadenylate459.6IL2, IL10, IFNG, IDO1
32neopterin459.6IDO1, IFNG, IL10, IL2
33ionomycin459.6IL2, IL10, IFNG
34rantes459.6TGFB1, IL2, IFNG, IDO1
35il 10459.6TGFB1, IL2, IL10, IFNG
36tacrolimus45 50 1111.5TGFB1, IL2, IL10, IFNG
37calcitriol45 60 11 2412.5TGFB1, IL2, IL10, IFNG
38imiquimod45 29 60 1112.5IL10, IFNG
39histamine45 29 2411.5IFNG, IL10, IL2, TGFB1
40cyclosporin a45 29 6011.4IFNG, IL10, IL2, TGFB1
41dmso459.4TGFB1, IL2, IL10
42thymidine45 2410.3IDO1, IFNG, IL10, IL2, TGFB1
43pge2458.7IDO1, IFNG, TNFAIP6, IL10, IL2, TGFB1
44dexamethasone45 50 29 1111.7IDO1, IFNG, TNFAIP6, IL10, IL2, TGFB1

GO Terms for genes affiliated with Chronic Active Epstein-Barr Virus Infection

Sources:
16Gene Ontology
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Biological processes related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.0IL2, IFNG
2positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IFNG
3positive regulation of interleukin-17 productionGO:03274010.0TGFB1, IL2
4negative regulation of growth of symbiont in hostGO:0441309.9IL10, IFNG
5negative regulation of DNA replicationGO:0081569.9ATR, TGFB1
6negative regulation of T cell proliferationGO:0421309.8TGFB1, IL10
7protein import into nucleus, translocationGO:0000609.8TGFB1, IFNG
8positive regulation of interleukin-12 productionGO:0327359.7IFNG, IDO1
9extrinsic apoptotic signaling pathwayGO:0971919.5TGFB1, IFNG

Molecular functions related to Chronic Active Epstein-Barr Virus Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IL2, IL10, IFNG
2growth factor activityGO:0080839.2TGFB1, IL2, IL10

Products for genes affiliated with Chronic Active Epstein-Barr Virus Infection

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Sources for Chronic Active Epstein-Barr Virus Infection

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet