MCID: CHR013
MIFTS: 30

Chronic Apical Periodontitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

Aliases & Descriptions for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 14 69
Chronic Apical Periodontitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD10 33 K04.5
ICD9CM 35 522.6
UMLS 69 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and periapical periodontitis. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Osteoclast differentiation and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Epinephrine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 periodontitis 10.5
2 periapical periodontitis 10.2
3 phka2-related phosphorylase kinase deficiency 10.2 TNFRSF11B TNFSF11
4 birk-barel mental retardation dysmorphism syndrome 10.2 TNFRSF11B TNFSF11
5 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11B TNFSF11
6 hepatic fibrosis renal cysts mental retardation 10.2 TNFRSF11B TNFSF11
7 cortical blindness 10.2 TNFRSF11B TNFSF11
8 epilepsy, idiopathic generalized 14 10.2 TNFRSF11B TNFSF11
9 polyomavirus allograft nephropathy 10.2 TNFRSF11B TNFSF11
10 microcephaly 10, primary, autosomal recessive 10.2 TNFRSF11B TNFSF11
11 maroteaux stanescu cousin syndrome 10.2 TNFRSF11B TNFSF11
12 bronchus cancer 10.2 TNFRSF11B TNFSF11
13 acrorenal syndrome 10.2 TNFRSF11B TNFSF11
14 glossitis 10.2 TNFRSF11B TNFSF11
15 chromosomal disease 10.1 TNFRSF11B TNFSF11
16 exudative vitreoretinopathy 4 10.1 TNFRSF11B TNFSF11
17 post-traumatic stress disorder 10.1 TNFRSF11B TNFSF11
18 celiac disease 10.1 TNFRSF11B TNFSF11
19 dysbaric osteonecrosis 10.1 TNFRSF11B TNFSF11
20 ischemic bone disease 10.1 TNFRSF11B TNFSF11
21 preretinal fibrosis 10.1 TNFRSF11B TNFSF11
22 vascular dementia 10.1 TNFRSF11B TNFSF11
23 intrahepatic cholestasis 10.1 TNFRSF11B TNFSF11
24 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.1 TNFRSF11B TNFSF11
25 fungal gastritis 10.1 TNFRSF11B TNFSF11
26 synovium cancer 10.1 TNFRSF11B TNFSF11
27 cranial nerve palsy 10.1 TNFRSF11B TNFSF11
28 bone angioendothelial sarcoma 10.0 TNFRSF11B TNFSF11
29 bladder papillary transitional cell neoplasm 10.0 TNFRSF11B TNFSF11
30 intratubular embryonal carcinoma 10.0 TNFRSF11B TNFSF11
31 sucla2-related mitochondrial dna depletion syndrome, encephalomyopathic form with methylmalonic aciduria 10.0 SLC52A2 SLC52A3
32 ring chromosome 12 10.0 SLC52A2 SLC52A3
33 malignant cylindroma 10.0 SLC52A2 SLC52A3
34 histiocytosis 10.0 TNFRSF11B TNFSF11
35 breast intraductal proliferative lesion 10.0 SLC52A2 SLC52A3
36 chorioamnionitis 10.0 SLC52A2 SLC52A3
37 molybdenum cofactor deficiency a 9.9 TNFRSF11B TNFSF11
38 coronary artery disease 9.9
39 artery disease 9.9
40 bulbomembranous urethral cancer 9.7 SASS6 SLC52A2 TNFRSF11B TNFSF11
41 atherosclerosis 9.7
42 fibroma 9.7
43 root resorption 9.7
44 ossifying fibroma 9.7
45 paresthesia 9.7
46 peripheral scars of retina 9.2 IL34 SASS6 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2 Anesthetics Phase 4
3 Epinephryl borate Phase 4
4 Photosensitizing Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Racepinephrine Phase 4
7
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
8 Anti-Bacterial Agents
9 Antibiotics, Antitubercular
10 Dexamethasone acetate 1177-87-3
11 glucocorticoids
12
protease inhibitors
13 Gastrointestinal Agents
14 HIV Protease Inhibitors
15 Hormone Antagonists
16 Dexamethasone 21-phosphate
17 Hormones
18 Peripheral Nervous System Agents
19 Hormones, Hormone Substitutes, and Hormone Antagonists
20 Antiemetics
21 Anti-Inflammatory Agents
22 BB 1101
23 Autonomic Agents
24 Antineoplastic Agents, Hormonal

Interventional clinical trials:


id Name Status NCT ID Phase
1 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
2 Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession Completed NCT02835430 Phase 4
3 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
4 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
5 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1
6 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
7 Combined Use of Er:YAG and Nd:YAG Laser Completed NCT02851823
8 Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets Completed NCT02531555
9 Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs Periodontitis Completed NCT02664675
10 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Apical Abscess Not yet recruiting NCT03005522

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

39
Bone

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show all 27)
id Title Authors Year
1
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. ( 27118467 )
2016
2
Clinical, imagistic and histopathological study of chronic apical periodontitis. ( 27833964 )
2016
3
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. ( 26406018 )
2015
4
Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis. ( 26666260 )
2015
5
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. ( 25826508 )
2015
6
Association between chronic apical periodontitis and low-birth-weight preterm births. ( 25576210 )
2015
7
Association between chronic apical periodontitis and coronary artery disease. ( 24461397 )
2014
8
Chronic apical periodontitis is more common in subjects with coronary artery disease. ( 25234220 )
2014
9
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. ( 25075670 )
2014
10
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. ( 24172007 )
2013
11
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. ( 24338091 )
2013
12
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. ( 24068408 )
2013
13
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. ( 21933620 )
2011
14
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. ( 20951289 )
2010
15
Ossifying fibroma misdiagnosed as chronic apical periodontitis. ( 20171381 )
2010
16
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. ( 20491984 )
2010
17
[Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. ( 18278135 )
2008
18
Root canal microbiota of teeth with chronic apical periodontitis. ( 18768651 )
2008
19
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. ( 19026873 )
2008
20
The influence of chronic apical periodontitis on oral and general health. ( 18078141 )
2007
21
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. ( 16186751 )
2005
22
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. ( 15220649 )
2004
23
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. ( 11556508 )
2001
24
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. ( 9206419 )
1996
25
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. ( 9028199 )
1996
26
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. ( 8247615 )
1993
27
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. ( 6945343 )
1981

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

GO Terms for Chronic Apical Periodontitis

Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.16 TNFRSF11B TNFSF11
2 riboflavin metabolic process GO:0006771 8.96 SLC52A2 SLC52A3
3 riboflavin transport GO:0032218 8.62 SLC52A2 SLC52A3

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL34 TNFRSF11B TNFSF11
2 riboflavin transporter activity GO:0032217 8.62 SLC52A2 SLC52A3

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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