MCID: CHR013
MIFTS: 28

Chronic Apical Periodontitis malady

Gastrointestinal diseases category

Aliases & Classifications for Chronic Apical Periodontitis

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Chronic Apical Periodontitis, Aliases & Descriptions:

Name: Chronic Apical Periodontitis 9 11 60
 
Chronic Apical Periodontitis Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:11269
ICD9CM27 522.6
ICD1025 K04.5

Summaries for Chronic Apical Periodontitis

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MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and coronary artery disease. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

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Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.3TNFRSF11B, TNFSF11
2coronary artery disease30.2TNFSF11, TNFRSF11B, CRP
3artery disease10.4
4periapical granuloma10.3TNFSF11
5atherosclerosis10.2
6ossifying fibroma10.2
7fibroma10.2
8root resorption10.2
9paresthesia10.2
10uremia10.1CRP, TNFRSF11B
11osteomyelitis10.0TNFSF11, CRP
12lipid metabolism disorder10.0TNFRSF11B, CRP
13osteolysis, familial expansile10.0TNFRSF11B, TNFSF11
14paget disease, juvenile10.0TNFRSF11B, TNFSF11
15hyperostosis, endosteal10.0TNFRSF11B, TNFSF11
16marchiafava bignami disease10.0TNFSF11, TNFRSF11B
17aortic valve disease 210.0TNFRSF11B, TNFSF11
18periodontal disease10.0CRP, TNFSF11
19gingivitis10.0TNFSF11, TNFRSF11B
20thalassemia, hispanic gamma-delta-beta10.0TNFSF11, TNFRSF11B
21giant cell tumor10.0TNFSF11, TNFRSF11B
22ameloblastoma10.0TNFRSF11B, TNFSF11
23cholesteatoma10.0TNFSF11, TNFRSF11B
24osteopetrosis10.0TNFRSF11B, TNFSF11
25bone cancer10.0TNFSF11, TNFRSF11B
26hyperparathyroidism9.9TNFRSF11B, TNFSF11
27hypercalcemia9.9TNFSF11, TNFRSF11B
28secondary syphilis9.9TNFRSF11B, TNFSF11
29acute myocardial infarction9.9CRP, TNFSF11
30multiple myeloma9.9TNFRSF11B, TNFSF11
31myeloma9.8TNFRSF11B, TNFSF11
32psoriatic arthritis9.8CRP, TNFRSF11B, TNFSF11
33spondyloarthropathy 19.8CRP, TNFRSF11B, TNFSF11
34arthropathy9.8TNFSF11, TNFRSF11B, CRP
35osteoporosis9.8TNFRSF11B, TNFSF11
36rheumatic disease9.8CRP, TNFRSF11B, TNFSF11
37synovitis9.8CRP, TNFRSF11B, TNFSF11
38vascular disease9.8TNFSF11, TNFRSF11B, CRP
39chronic kidney failure9.8CRP, TNFRSF11B, TNFSF11
40osteoarthritis9.8CRP, TNFRSF11B, TNFSF11
41arthritis9.8CRP, TNFRSF11B, TNFSF11
42primary hyperoxaluria9.8TNFSF11, TNFRSF11B, CRP
43ulcerative colitis9.7CRP, TNFSF11
44rheumatoid arthritis9.7CRP, TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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MalaCards organs/tissues related to Chronic Apical Periodontitis:

31
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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Publications for Chronic Apical Periodontitis

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Articles related to Chronic Apical Periodontitis:

(show all 23)
idTitleAuthorsYear
1
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. (25826508)
2015
2
Association between chronic apical periodontitis and low-birth-weight preterm births. (25576210)
2015
3
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
4
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
5
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
6
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
7
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
8
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
9
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
10
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
11
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
12
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
13
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
14
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
15
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
16
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
17
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
18
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
19
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
20
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
21
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
22
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
23
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CRP, TNFSF11
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFRSF11B, TNFSF11
49.0TNFRSF11B, TNFSF11
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.0TNFSF11, TNFRSF11B
79.0TNFRSF11B, TNFSF11
89.0TNFRSF11B, TNFSF11
99.0TNFRSF11B, TNFSF11

Compounds for genes affiliated with Chronic Apical Periodontitis

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Compounds related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra43 1210.7TNFRSF11B, CRP
2nitroglycerin43 1210.7CRP, TNFRSF11B
3p005439.7CRP, TNFRSF11B
4p003439.5CRP, TNFRSF11B
5hcc-1439.5TNFRSF11B, TNFSF11
6denosumab43 1210.5TNFRSF11B, TNFSF11
7teriparatide43 1210.5TNFRSF11B, TNFSF11
8ibandronate43 1210.5TNFSF11, TNFRSF11B
9polyethylene439.5TNFSF11, TNFRSF11B
10vitamin k2439.4TNFRSF11B, TNFSF11
11homocysteine43 2410.4CRP, TNFRSF11B
12risedronate43 49 28 59 1213.4TNFRSF11B, TNFSF11
13clodronate43 49 1211.4TNFRSF11B, TNFSF11
14geranylgeranyl pyrophosphate439.4TNFRSF11B, TNFSF11
15titanium439.4TNFRSF11B, TNFSF11
16zoledronic acid439.4TNFSF11, TNFRSF11B
17polymyxin b439.4TNFSF11, TNFRSF11B
18alendronate43 49 1211.4TNFRSF11B, TNFSF11
19p002439.4CRP, TNFRSF11B
20ns 39843 5910.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.4TNFRSF11B, TNFSF11
22phosphorus439.4TNFRSF11B, TNFSF11
23raloxifene43 49 28 1212.4TNFRSF11B, TNFSF11
24mevalonate439.3TNFSF11, TNFRSF11B
25latex439.3CRP, TNFSF11
26atorvastatin43 49 28 24 1213.3TNFRSF11B, CRP
27hydroxyapatite439.3TNFRSF11B, TNFSF11
28dhea439.3TNFSF11, TNFRSF11B
29celecoxib43 59 28 49 24 1214.3TNFRSF11B, TNFSF11
30procollagen439.3TNFSF11, TNFRSF11B
31gp 130439.3TNFRSF11B, TNFSF11
32prednisolone43 28 1211.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3439.2TNFSF11, TNFRSF11B
34heparan sulfate43 2410.0TNFRSF11B, TNFSF11
35pamidronate43 49 1211.0CRP, TNFRSF11B, TNFSF11
36pmma439.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline439.0TNFSF11, TNFRSF11B, CRP
3825-hydroxyvitamin d439.0CRP, TNFRSF11B, TNFSF11
39etanercept43 49 1211.0TNFSF11, TNFRSF11B, CRP
40infliximab43 49 1210.9CRP, TNFRSF11B, TNFSF11
41azathioprine43 2 49 1211.9TNFSF11, TNFRSF11B, CRP
42methotrexate49 43 1210.9CRP, TNFRSF11B, TNFSF11
43ascorbic acid43 249.9CRP, TNFRSF11B, TNFSF11
44sb 20358043 599.9TNFSF11, TNFRSF11B, CRP
45ly294002438.9TNFSF11, TNFRSF11B, CRP
46creatinine438.9CRP, TNFRSF11B, TNFSF11
47cycloheximide438.8TNFSF11, TNFRSF11B, CRP
48testosterone43 59 24 1211.8CRP, TNFRSF11B, TNFSF11
49vegf438.8CRP, TNFRSF11B, TNFSF11
50urea43 24 1210.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

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Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:00056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Chronic Apical Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet