MCID: CHR013
MIFTS: 28

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 14 69
Chronic Apical Periodontitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD10 33 K04.5
ICD9CM 35 522.6
UMLS 69 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and polyembryoma. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Osteoclast differentiation and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 periodontitis 10.5
2 polyembryoma 10.4 TNFRSF11B TNFSF11
3 tibial hemimelia 10.4 TNFRSF11B TNFSF11
4 paget disease of bone 2, early-onset 10.4 TNFRSF11B TNFSF11
5 hennekam van der horst syndrome 10.4 TNFRSF11B TNFSF11
6 cortical blindness 10.4 TNFRSF11B TNFSF11
7 spinocerebellar ataxia 4 10.4 TNFRSF11B TNFSF11
8 metaphyseal anadysplasia 2 10.4 TNFRSF11B TNFSF11
9 bronchus cancer 10.3 TNFRSF11B TNFSF11
10 bacillary angiomatosis 10.3 TNFRSF11B TNFSF11
11 bone resorption disease 10.3 TNFRSF11B TNFSF11
12 glossitis 10.3 TNFRSF11B TNFSF11
13 van buchem disease, type 2 10.3 TNFRSF11B TNFSF11
14 physical disorder 10.3 TNFRSF11B TNFSF11
15 bone deterioration disease 10.3 TNFRSF11B TNFSF11
16 ovarian insufficiency, familial 10.3 TNFRSF11B TNFSF11
17 psoriasis susceptibility 1 10.3 TNFRSF11B TNFSF11
18 preretinal fibrosis 10.2 TNFRSF11B TNFSF11
19 neuropathy 10.2 TNFRSF11B TNFSF11
20 mesenchymal cell neoplasm 10.2 TNFRSF11B TNFSF11
21 periapical periodontitis 10.2
22 bacterial gastritis 10.2 TNFRSF11B TNFSF11
23 craniosynostosis 7 10.2 TNFRSF11B TNFSF11
24 synovium cancer 10.1 TNFRSF11B TNFSF11
25 vulva fibroepithelial polyp 10.1 TNFRSF11B TNFSF11
26 glossopharyngeal nerve paralysis 10.1 TNFRSF11B TNFSF11
27 schizoaffective disorder 10.0 TNFRSF11B TNFSF11
28 small cell cancer of the lung, somatic 10.0 TNFRSF11B TNFSF11
29 male infertility with spermatogenesis disorder 9.9 SLC52A2 SLC52A3
30 inappropriate adh syndrome 9.9 TNFRSF11B TNFSF11
31 coronary artery disease 9.9
32 artery disease 9.9
33 compartment syndrome 9.9 SLC52A2 SLC52A3
34 fetal alcohol spectrum disorder 9.9 SLC52A2 SLC52A3
35 fibroma 9.7
36 root resorption 9.7
37 ossifying fibroma 9.7
38 paresthesia 9.7
39 atherosclerosis 9.7
40 adenoiditis 9.7
41 leprosy 4 9.7 TNFRSF11B TNFSF11
42 lower clivus meningioma 9.2 SASS6 SLC52A2 TNFRSF11B TNFSF11
43 peripheral scars of retina 7.9 IL34 SASS6 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2 Racepinephrine Approved
3 Epinephryl borate
4
s 1 (combination)
5 Anti-Infective Agents
6 Disinfectants
7 Eusol
8 Pharmaceutical Solutions
9 Sodium hypochlorite

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
2 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
3 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054
4 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1
5 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
6 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Active, not recruiting NCT03288467

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

39
Bone

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show all 29)
id Title Authors Year
1
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. ( 28455694 )
2017
2
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017
3
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. ( 27118467 )
2016
4
Clinical, imagistic and histopathological study of chronic apical periodontitis. ( 27833964 )
2016
5
Association between chronic apical periodontitis and low-birth-weight preterm births. ( 25576210 )
2015
6
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. ( 25826508 )
2015
7
Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis. ( 26666260 )
2015
8
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. ( 26406018 )
2015
9
Association between chronic apical periodontitis and coronary artery disease. ( 24461397 )
2014
10
Chronic apical periodontitis is more common in subjects with coronary artery disease. ( 25234220 )
2014
11
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. ( 25075670 )
2014
12
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. ( 24338091 )
2013
13
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. ( 24068408 )
2013
14
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. ( 24172007 )
2013
15
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. ( 21933620 )
2011
16
Ossifying fibroma misdiagnosed as chronic apical periodontitis. ( 20171381 )
2010
17
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. ( 20951289 )
2010
18
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. ( 20491984 )
2010
19
Root canal microbiota of teeth with chronic apical periodontitis. ( 18768651 )
2008
20
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. ( 19026873 )
2008
21
[Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. ( 18278135 )
2008
22
The influence of chronic apical periodontitis on oral and general health. ( 18078141 )
2007
23
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. ( 16186751 )
2005
24
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. ( 15220649 )
2004
25
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. ( 11556508 )
2001
26
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. ( 9028199 )
1996
27
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. ( 9206419 )
1996
28
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. ( 8247615 )
1993
29
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. ( 6945343 )
1981

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

GO Terms for Chronic Apical Periodontitis

Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.16 TNFRSF11B TNFSF11
2 riboflavin metabolic process GO:0006771 8.96 SLC52A2 SLC52A3
3 riboflavin transport GO:0032218 8.62 SLC52A2 SLC52A3

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL34 TNFRSF11B TNFSF11
2 riboflavin transporter activity GO:0032217 8.62 SLC52A2 SLC52A3

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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