MCID: CHR013
MIFTS: 33

Chronic Apical Periodontitis malady

Gastrointestinal diseases category

Summaries for Chronic Apical Periodontitis

About this section


MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and coronary artery disease. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Chronic Apical Periodontitis

About this section

Chronic Apical Periodontitis, Aliases & Descriptions:

Name: Chronic Apical Periodontitis 10 12 62
 
Chronic Apical Periodontitis Nos 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology10 DOID:11269
ICD9CM29 522.6
ICD1027 K04.5

Related Diseases for Chronic Apical Periodontitis

About this section

Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.4TNFRSF11B, TNFSF11
2coronary artery disease30.5TNFSF11, CRP, TNFRSF11B
3artery disease10.4
4atherosclerosis10.2
5ossifying fibroma10.2
6fibroma10.2
7root resorption10.2
8paresthesia10.2
9periapical granuloma10.0TNFSF11
10uremia10.0CRP, TNFRSF11B
11osteomyelitis10.0CRP, TNFSF11
12lipid metabolism disorder10.0TNFRSF11B, CRP
13paget disease, juvenile10.0TNFRSF11B, TNFSF11
14osteolysis, familial expansile10.0TNFRSF11B, TNFSF11
15hyperostosis, endosteal10.0TNFRSF11B, TNFSF11
16aortic valve disease 210.0TNFSF11, TNFRSF11B
17periodontal disease10.0CRP, TNFSF11
18gingivitis10.0TNFSF11, TNFRSF11B
19thalassemia, hispanic gamma-delta-beta10.0TNFSF11, TNFRSF11B
20giant cell tumor10.0TNFSF11, TNFRSF11B
21ameloblastoma10.0TNFRSF11B, TNFSF11
22cholesteatoma10.0TNFSF11, TNFRSF11B
23osteopetrosis10.0TNFSF11, TNFRSF11B
24bone cancer10.0TNFSF11, TNFRSF11B
25hyperparathyroidism10.0TNFSF11, TNFRSF11B
26hypercalcemia10.0TNFSF11, TNFRSF11B
27secondary syphilis10.0TNFSF11, TNFRSF11B
28acute myocardial infarction10.0CRP, TNFSF11
29multiple myeloma10.0TNFSF11, TNFRSF11B
30myeloma10.0TNFRSF11B, TNFSF11
31psoriatic arthritis10.0TNFRSF11B, CRP, TNFSF11
32spondyloarthropathy 110.0TNFRSF11B, TNFSF11, CRP
33osteoporosis10.0TNFRSF11B, TNFSF11
34arthropathy10.0TNFRSF11B, TNFSF11, CRP
35rheumatic disease10.0TNFSF11, TNFRSF11B, CRP
36synovitis10.0TNFRSF11B, CRP, TNFSF11
37vascular disease10.0TNFRSF11B, TNFSF11, CRP
38chronic kidney failure10.0CRP, TNFSF11, TNFRSF11B
39osteoarthritis10.0TNFSF11, TNFRSF11B, CRP
40arthritis10.0CRP, TNFSF11, TNFRSF11B
41primary hyperoxaluria10.0TNFSF11, TNFRSF11B, CRP
42ulcerative colitis10.0TNFSF11, CRP
43rheumatoid arthritis10.0TNFSF11, TNFRSF11B, CRP

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

About this section

Drugs & Therapeutics for Chronic Apical Periodontitis

About this section

Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

About this section

Anatomical Context for Chronic Apical Periodontitis

About this section

MalaCards organs/tissues related to Chronic Apical Periodontitis:

33
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

About this section

Publications for Chronic Apical Periodontitis

About this section

Articles related to Chronic Apical Periodontitis:

(show all 23)
idTitleAuthorsYear
1
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. (25826508)
2015
2
Association between chronic apical periodontitis and low-birth-weight preterm births. (25576210)
2015
3
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
4
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
5
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
6
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
7
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
8
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
9
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
10
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
11
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
12
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
13
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
14
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
15
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
16
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
17
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
18
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
19
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
20
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
21
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
22
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
23
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

About this section

Expression for genes affiliated with Chronic Apical Periodontitis

About this section

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

About this section

Pathways related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CRP, TNFSF11
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFRSF11B, TNFSF11
49.0TNFRSF11B, TNFSF11
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway38
Apoptosis and survival APRIL and BAFF signaling60
9.0TNFSF11, TNFRSF11B
79.0TNFRSF11B, TNFSF11
89.0TNFRSF11B, TNFSF11
99.0TNFRSF11B, TNFSF11

Compounds for genes affiliated with Chronic Apical Periodontitis

About this section

Compounds related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra45 1310.7TNFRSF11B, CRP
2nitroglycerin45 1310.7CRP, TNFRSF11B
3p005459.7CRP, TNFRSF11B
4p003459.5CRP, TNFRSF11B
5hcc-1459.5TNFRSF11B, TNFSF11
6denosumab45 1310.5TNFRSF11B, TNFSF11
7teriparatide45 1310.5TNFRSF11B, TNFSF11
8ibandronate45 1310.5TNFSF11, TNFRSF11B
9polyethylene459.5TNFSF11, TNFRSF11B
10vitamin k2459.4TNFRSF11B, TNFSF11
11homocysteine45 2610.4CRP, TNFRSF11B
12risedronate45 51 30 61 1313.4TNFRSF11B, TNFSF11
13clodronate45 51 1311.4TNFRSF11B, TNFSF11
14geranylgeranyl pyrophosphate459.4TNFRSF11B, TNFSF11
15titanium459.4TNFRSF11B, TNFSF11
16zoledronic acid459.4TNFSF11, TNFRSF11B
17polymyxin b459.4TNFSF11, TNFRSF11B
18alendronate45 51 1311.4TNFRSF11B, TNFSF11
19p002459.4CRP, TNFRSF11B
20ns 39845 6110.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4TNFRSF11B, TNFSF11
22phosphorus459.4TNFRSF11B, TNFSF11
23raloxifene45 51 30 1312.4TNFRSF11B, TNFSF11
24mevalonate459.3TNFSF11, TNFRSF11B
25latex459.3CRP, TNFSF11
26atorvastatin45 51 30 26 1313.3TNFRSF11B, CRP
27hydroxyapatite459.3TNFRSF11B, TNFSF11
28dhea459.3TNFSF11, TNFRSF11B
29celecoxib45 61 30 51 26 1314.3TNFRSF11B, TNFSF11
30procollagen459.3TNFSF11, TNFRSF11B
31gp 130459.3TNFRSF11B, TNFSF11
32prednisolone45 30 1311.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3459.2TNFSF11, TNFRSF11B
34heparan sulfate45 2610.0TNFRSF11B, TNFSF11
35pamidronate45 51 1311.0CRP, TNFRSF11B, TNFSF11
36pmma459.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline459.0TNFSF11, TNFRSF11B, CRP
3825-hydroxyvitamin d459.0CRP, TNFRSF11B, TNFSF11
39etanercept45 51 1311.0TNFSF11, TNFRSF11B, CRP
40infliximab45 51 1310.9CRP, TNFRSF11B, TNFSF11
41azathioprine45 3 51 1311.9TNFSF11, TNFRSF11B, CRP
42methotrexate51 45 1310.9CRP, TNFRSF11B, TNFSF11
43ascorbic acid45 269.9CRP, TNFRSF11B, TNFSF11
44sb 20358045 619.9TNFSF11, TNFRSF11B, CRP
45ly294002458.9TNFSF11, TNFRSF11B, CRP
46creatinine458.9CRP, TNFRSF11B, TNFSF11
47cycloheximide458.8TNFSF11, TNFRSF11B, CRP
48testosterone45 61 26 1311.8CRP, TNFRSF11B, TNFSF11
49vegf458.8CRP, TNFRSF11B, TNFSF11
50urea45 26 1310.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

About this section

Cellular components related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:00056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Chronic Apical Periodontitis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet