MCID: CHR013
MIFTS: 26

Chronic Apical Periodontitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

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Aliases & Descriptions for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 11 13 66
 
Chronic Apical Periodontitis Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:11269
ICD1028 K04.5
ICD9CM30 522.6

Summaries for Chronic Apical Periodontitis

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MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and osteopetrosis, autosomal recessive 7. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways are Osteoclast differentiation and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

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Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis10.6
2osteopetrosis, autosomal recessive 710.4TNFRSF11B, TNFSF11
3hemorrhagic shock and encephalopathy syndrome10.3TNFRSF11B, TNFSF11
4tibial hemimelia10.3TNFRSF11B, TNFSF11
5myopia10.3TNFRSF11B, TNFSF11
6juvenile retinoschisis10.3TNFRSF11B, TNFSF11
7periapical periodontitis10.3
8pneumatosis cystoides intestinalis10.3TNFRSF11B, TNFSF11
9bacillary angiomatosis10.3TNFRSF11B, TNFSF11
10acquired hyperkeratosis10.3TNFRSF11B, TNFSF11
11anaerobic meningitis10.3TNFRSF11B, TNFSF11
12bone resorption disease10.3TNFRSF11B, TNFSF11
13van buchem disease, type 210.3TNFRSF11B, TNFSF11
14physical disorder10.3TNFRSF11B, TNFSF11
15subacute monocytic leukemia10.2TNFRSF11B, TNFSF11
16bone deterioration disease10.2TNFRSF11B, TNFSF11
17neuroma10.2TNFRSF11B, TNFSF11
18eosinophilic gastroenteritis10.2TNFRSF11B, TNFSF11
19psoriasis susceptibility 110.2TNFRSF11B, TNFSF11
20xanthomatosis10.2TNFRSF11B, TNFSF11
21cannabis dependence10.1TNFRSF11B, TNFSF11
22palmoplantar keratosis10.1TNFRSF11B, TNFSF11
23lung occult small cell carcinoma10.0TNFRSF11B, TNFSF11
24coronary artery disease10.0
25artery disease10.0
26chronic rhinitis10.0TNFRSF11B, TNFSF11
27small cell cancer of the lung, somatic10.0TNFRSF11B, TNFSF11
28scn1a-related seizure disorders9.9SLC52A2, SLC52A3
29brunoni syndrome9.9SLC52A2, SLC52A3
30mahvash disease9.9SLC52A2, SLC52A3
31leprosy 49.9TNFRSF11B, TNFSF11
32childhood pilocytic astrocytoma9.9SLC52A2, SLC52A3
33atherosclerosis9.9
34fibroma9.9
35root resorption9.9
36ossifying fibroma9.9
37paresthesia9.9
38fetal alcohol spectrum disorder9.8SLC52A2, SLC52A3
39brain stem angioblastoma9.7TNFRSF11B, TNFSF11
40inflammatory liposarcoma9.3SASS6, SLC52A2, TNFRSF11B, TNFSF11
41solar retinopathy8.0IL34, SASS6, SLC52A2, SLC52A3, TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EpinephrinePhase 488651-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9

Interventional clinical trials:

idNameStatusNCT IDPhase
1Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival RecessionCompletedNCT02835430Phase 4
2Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic TherapyRecruitingNCT01532674Phase 4
3Longitudinal Endodontic Study of Apical Preparation SizeCompletedNCT00223379
4Cytokine Regulation of Periradicular Pain in HumansCompletedNCT00223470
5Measurement of Bite Force in HumansCompletedNCT00223327Phase 0
6Postoperative Pain After the Removal of Root Canal Filling MaterialCompletedNCT02905773Phase 0
7Combined Use of Er:YAG and Nd:YAG LaserCompletedNCT02851823
8Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal PocketsCompletedNCT02531555
9Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs PeriodontitisCompletedNCT02664675

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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MalaCards organs/tissues related to Chronic Apical Periodontitis:

34
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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Publications for Chronic Apical Periodontitis

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Articles related to Chronic Apical Periodontitis:

(show all 26)
idTitleAuthorsYear
1
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. (27118467)
2016
2
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. (25826508)
2015
3
Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis. (26666260)
2015
4
Association between chronic apical periodontitis and low-birth-weight preterm births. (25576210)
2015
5
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. (26406018)
2015
6
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
7
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
8
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
9
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
10
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
11
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
12
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
13
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
14
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
15
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
16
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
17
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
18
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
19
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
20
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
21
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
22
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
23
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
24
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
25
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
26
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6TNFRSF11B, TNFSF11
29.6TNFRSF11B, TNFSF11
39.6TNFRSF11B, TNFSF11
49.6TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

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Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.3SLC52A2, SLC52A3, TNFRSF11B, TNFSF11

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-mediated signaling pathwayGO:00332099.6TNFRSF11B, TNFSF11
2riboflavin transportGO:00322189.6SLC52A2, SLC52A3

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1riboflavin transporter activityGO:00322179.6SLC52A2, SLC52A3
2cytokine activityGO:00051259.1IL34, TNFRSF11B, TNFSF11

Sources for Chronic Apical Periodontitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet