MCID: CHR013
MIFTS: 33

Chronic Apical Periodontitis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Chronic Apical Periodontitis

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34MalaCards
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MalaCards: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and ossifying fibroma. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Chronic Apical Periodontitis

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

chronic apical periodontitis 9 11 63
chronic apical periodontitis nos 9


External Ids:

Disease Ontology9 DOID:11269
ICD9CM28 522.6
ICD1026 K04.5

Related Diseases for Chronic Apical Periodontitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Chronic Apical Periodontitis family:

Acute Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.2TNFRSF11B, TNFSF11
2ossifying fibroma10.2
3fibroma10.2
4atherosclerosis10.2
5paresthesia10.2
6periapical granuloma10.1TNFSF11
7uremia10.0CRP, TNFRSF11B
8osteomyelitis10.0CRP, TNFSF11
9paget disease, juvenile10.0TNFRSF11B, TNFSF11
10polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11B, TNFSF11
11osteosclerosis10.0TNFRSF11B, TNFSF11
12aortic valve stenosis10.0TNFSF11, TNFRSF11B
13periodontal disease10.0CRP, TNFSF11
14gingivitis10.0TNFSF11, TNFRSF11B
15beta thalassemia10.0TNFSF11, TNFRSF11B
16giant cell tumor10.0TNFSF11, TNFRSF11B
17osteoporosis, postmenopausal10.0TNFSF11, TNFRSF11B
18adenoameloblastoma10.0TNFRSF11B, TNFSF11
19cholesteatoma10.0TNFSF11, TNFRSF11B
20osteopetrosis10.0TNFSF11, TNFRSF11B
21bone carcinoma10.0TNFSF11, TNFRSF11B
22hyperparathyroidism10.0TNFSF11, TNFRSF11B
23hypercalcemia10.0TNFSF11, TNFRSF11B
24secondary syphilis10.0TNFSF11, TNFRSF11B
25acute myocardial infarction10.0CRP, TNFSF11
26multiple myeloma10.0TNFSF11, TNFRSF11B
27myeloma10.0TNFRSF11B, TNFSF11
28psoriatic arthritis9.9TNFRSF11B, CRP, TNFSF11
29osteoporosis9.9TNFRSF11B, TNFSF11
30ankylosing spondylitis9.9TNFRSF11B, TNFSF11, CRP
31arthropathy9.9TNFRSF11B, TNFSF11, CRP
32rheumatic disease9.9TNFSF11, TNFRSF11B, CRP
33synovitis9.9TNFRSF11B, CRP, TNFSF11
34vascular disease9.9TNFRSF11B, TNFSF11, CRP
35coronary artery disease9.9TNFSF11, CRP, TNFRSF11B
36chronic kidney failure9.9CRP, TNFSF11, TNFRSF11B
37osteoarthritis9.9TNFSF11, TNFRSF11B, CRP
38arthritis9.9CRP, TNFSF11, TNFRSF11B
39primary hyperoxaluria9.9TNFSF11, TNFRSF11B, CRP
40ulcerative colitis9.9TNFSF11, CRP
41rheumatoid arthritis9.9TNFSF11, TNFRSF11B, CRP

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Apical Periodontitis

Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Search CenterWatch for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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34MalaCards
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MalaCards organs/tissues related to Chronic Apical Periodontitis:

34
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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Publications for Chronic Apical Periodontitis

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53PubMed
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Articles related to Chronic Apical Periodontitis:

(show all 17)
idTitleAuthorsYear
1
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
2
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
3
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
4
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
5
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
6
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
7
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
8
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
9
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
10
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
11
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
12
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
13
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
14
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
15
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
16
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
17
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 58SinoBiological, 55R&D Systems, 31KEGG, 61Thomson Reuters, 56Reactome
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Pathways related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1TNFSF11, CRP
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFSF11, TNFRSF11B
49.0TNFSF11, TNFRSF11B
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.0TNFRSF11B, TNFSF11
79.0TNFSF11, TNFRSF11B
89.0TNFRSF11B, TNFSF11
99.0TNFSF11, TNFRSF11B

Compounds for genes affiliated with Chronic Apical Periodontitis

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra46 1210.7TNFRSF11B, CRP
2nitroglycerin46 1210.7CRP, TNFRSF11B
3p005469.7CRP, TNFRSF11B
4p003469.5TNFRSF11B, CRP
5hcc-1469.5TNFSF11, TNFRSF11B
6denosumab46 1210.5TNFRSF11B, TNFSF11
7teriparatide46 1210.5TNFRSF11B, TNFSF11
8ibandronate46 1210.5TNFRSF11B, TNFSF11
9polyethylene469.5TNFRSF11B, TNFSF11
10vitamin k2469.4TNFRSF11B, TNFSF11
11homocysteine46 2510.4TNFRSF11B, CRP
12risedronate46 52 30 62 1213.4TNFSF11, TNFRSF11B
13clodronate46 52 1211.4TNFSF11, TNFRSF11B
14geranylgeranyl pyrophosphate469.4TNFSF11, TNFRSF11B
15titanium469.4TNFSF11, TNFRSF11B
16polymyxin b469.4TNFSF11, TNFRSF11B
17zoledronic acid469.4TNFSF11, TNFRSF11B
18alendronate46 52 1211.4TNFSF11, TNFRSF11B
19p002469.4TNFRSF11B, CRP
20ns 39846 6210.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.4TNFSF11, TNFRSF11B
22phosphorus469.4TNFSF11, TNFRSF11B
23raloxifene46 52 30 1212.4TNFSF11, TNFRSF11B
24mevalonate469.3TNFRSF11B, TNFSF11
25latex469.3CRP, TNFSF11
26prednisolone46 30 1211.3TNFRSF11B, CRP
27hydroxyapatite469.3TNFSF11, TNFRSF11B
28dhea469.3TNFRSF11B, TNFSF11
29celecoxib46 62 30 52 25 1214.3TNFRSF11B, TNFSF11
30procollagen469.3TNFSF11, TNFRSF11B
31gp 130469.3TNFSF11, TNFRSF11B
32atorvastatin46 52 30 25 1213.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3469.2TNFSF11, TNFRSF11B
34heparan sulfate46 2510.0TNFSF11, TNFRSF11B
35pamidronate46 52 1211.0CRP, TNFRSF11B, TNFSF11
36pmma469.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline469.0CRP, TNFSF11, TNFRSF11B
3825-hydroxyvitamin d469.0CRP, TNFSF11, TNFRSF11B
39etanercept46 52 1211.0TNFSF11, TNFRSF11B, CRP
40infliximab46 52 1210.9TNFSF11, CRP, TNFRSF11B
41azathioprine46 3 52 1211.9CRP, TNFSF11, TNFRSF11B
42methotrexate52 46 1210.9TNFRSF11B, CRP, TNFSF11
43ascorbic acid46 259.9CRP, TNFRSF11B, TNFSF11
44sb 20358046 629.9CRP, TNFSF11, TNFRSF11B
45ly294002468.9CRP, TNFRSF11B, TNFSF11
46creatinine468.9CRP, TNFRSF11B, TNFSF11
47cycloheximide468.8TNFRSF11B, CRP, TNFSF11
48testosterone46 62 25 1211.8CRP, TNFSF11, TNFRSF11B
49vegf468.8TNFSF11, CRP, TNFRSF11B
50urea46 25 1210.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

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17Gene Ontology
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Cellular components related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:0056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Apical Periodontitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet