MCID: CHR013
MIFTS: 33

Chronic Apical Periodontitis malady

Gastrointestinal diseases, Oral diseases categories
Download this MalaCard

Summaries for Chronic Apical Periodontitis

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and ossifying fibroma. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Chronic Apical Periodontitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

chronic apical periodontitis 8 10 62
chronic apical periodontitis nos 8


External Ids:

Disease Ontology8 DOID:11269
ICD9CM27 522.6
ICD1025 K04.5

Related Diseases for Chronic Apical Periodontitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Apical Periodontitis family:

Acute Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.2TNFRSF11B, TNFSF11
2ossifying fibroma10.2
3fibroma10.2
4atherosclerosis10.2
5paresthesia10.2
6periapical granuloma10.1TNFSF11
7uremia10.0CRP, TNFRSF11B
8osteomyelitis10.0CRP, TNFSF11
9paget disease, juvenile10.0TNFRSF11B, TNFSF11
10polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11B, TNFSF11
11osteosclerosis10.0TNFRSF11B, TNFSF11
12aortic valve stenosis10.0TNFSF11, TNFRSF11B
13periodontal disease10.0CRP, TNFSF11
14gingivitis10.0TNFSF11, TNFRSF11B
15beta thalassemia10.0TNFSF11, TNFRSF11B
16giant cell tumor10.0TNFSF11, TNFRSF11B
17osteoporosis, postmenopausal10.0TNFSF11, TNFRSF11B
18adenoameloblastoma10.0TNFRSF11B, TNFSF11
19cholesteatoma10.0TNFSF11, TNFRSF11B
20osteopetrosis10.0TNFSF11, TNFRSF11B
21bone carcinoma10.0TNFSF11, TNFRSF11B
22hyperparathyroidism10.0TNFSF11, TNFRSF11B
23hypercalcemia10.0TNFSF11, TNFRSF11B
24secondary syphilis10.0TNFSF11, TNFRSF11B
25acute myocardial infarction10.0CRP, TNFSF11
26multiple myeloma10.0TNFSF11, TNFRSF11B
27myeloma10.0TNFRSF11B, TNFSF11
28psoriatic arthritis9.9TNFRSF11B, CRP, TNFSF11
29osteoporosis9.9TNFRSF11B, TNFSF11
30ankylosing spondylitis9.9TNFRSF11B, TNFSF11, CRP
31arthropathy9.9TNFRSF11B, TNFSF11, CRP
32rheumatic disease9.9TNFSF11, TNFRSF11B, CRP
33synovitis9.9TNFRSF11B, CRP, TNFSF11
34vascular disease9.9TNFRSF11B, TNFSF11, CRP
35coronary artery disease9.9TNFSF11, CRP, TNFRSF11B
36chronic kidney failure9.9CRP, TNFSF11, TNFRSF11B
37osteoarthritis9.9TNFSF11, TNFRSF11B, CRP
38arthritis9.9CRP, TNFSF11, TNFRSF11B
39primary hyperoxaluria9.9TNFSF11, TNFRSF11B, CRP
40ulcerative colitis9.9TNFSF11, CRP
41rheumatoid arthritis9.9TNFSF11, TNFRSF11B, CRP

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

About this section

Drugs & Therapeutics for Chronic Apical Periodontitis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

About this section

Anatomical Context for Chronic Apical Periodontitis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Apical Periodontitis:

33
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

About this section

Publications for Chronic Apical Periodontitis

About this section
Sources:
52PubMed
See all sources

Articles related to Chronic Apical Periodontitis:

(show all 17)
idTitleAuthorsYear
1
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
2
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
3
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
4
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
5
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
6
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
7
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
8
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
9
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
10
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
11
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
12
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
13
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
14
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
15
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
16
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
17
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

About this section

Expression for genes affiliated with Chronic Apical Periodontitis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 57SinoBiological, 54R&D Systems, 30KEGG, 60Thomson Reuters, 55Reactome
See all sources

Pathways related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1TNFSF11, CRP
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFSF11, TNFRSF11B
49.0TNFSF11, TNFRSF11B
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway38
Apoptosis and survival APRIL and BAFF signaling60
9.0TNFRSF11B, TNFSF11
79.0TNFSF11, TNFRSF11B
89.0TNFRSF11B, TNFSF11
99.0TNFSF11, TNFRSF11B

Compounds for genes affiliated with Chronic Apical Periodontitis

About this section
Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra45 1110.7TNFRSF11B, CRP
2nitroglycerin45 1110.7CRP, TNFRSF11B
3p005459.7CRP, TNFRSF11B
4p003459.5TNFRSF11B, CRP
5hcc-1459.5TNFSF11, TNFRSF11B
6denosumab45 1110.5TNFRSF11B, TNFSF11
7teriparatide45 1110.5TNFRSF11B, TNFSF11
8ibandronate45 1110.5TNFRSF11B, TNFSF11
9polyethylene459.5TNFRSF11B, TNFSF11
10vitamin k2459.4TNFRSF11B, TNFSF11
11homocysteine45 2410.4TNFRSF11B, CRP
12risedronate45 51 29 61 1113.4TNFSF11, TNFRSF11B
13clodronate45 51 1111.4TNFSF11, TNFRSF11B
14geranylgeranyl pyrophosphate459.4TNFSF11, TNFRSF11B
15titanium459.4TNFSF11, TNFRSF11B
16polymyxin b459.4TNFSF11, TNFRSF11B
17zoledronic acid459.4TNFSF11, TNFRSF11B
18alendronate45 51 1111.4TNFSF11, TNFRSF11B
19p002459.4TNFRSF11B, CRP
20ns 39845 6110.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4TNFSF11, TNFRSF11B
22phosphorus459.4TNFSF11, TNFRSF11B
23raloxifene45 51 29 1112.4TNFSF11, TNFRSF11B
24mevalonate459.3TNFRSF11B, TNFSF11
25latex459.3CRP, TNFSF11
26prednisolone45 29 1111.3TNFRSF11B, CRP
27hydroxyapatite459.3TNFSF11, TNFRSF11B
28dhea459.3TNFRSF11B, TNFSF11
29celecoxib45 61 29 51 24 1114.3TNFRSF11B, TNFSF11
30procollagen459.3TNFSF11, TNFRSF11B
31gp 130459.3TNFSF11, TNFRSF11B
32atorvastatin45 51 29 24 1113.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3459.2TNFSF11, TNFRSF11B
34heparan sulfate45 2410.0TNFSF11, TNFRSF11B
35pamidronate45 51 1111.0CRP, TNFRSF11B, TNFSF11
36pmma459.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline459.0CRP, TNFSF11, TNFRSF11B
3825-hydroxyvitamin d459.0CRP, TNFSF11, TNFRSF11B
39etanercept45 51 1111.0TNFSF11, TNFRSF11B, CRP
40infliximab45 51 1110.9TNFSF11, CRP, TNFRSF11B
41azathioprine45 3 51 1111.9CRP, TNFSF11, TNFRSF11B
42methotrexate51 45 1110.9TNFRSF11B, CRP, TNFSF11
43ascorbic acid45 249.9CRP, TNFRSF11B, TNFSF11
44sb 20358045 619.9CRP, TNFSF11, TNFRSF11B
45ly294002458.9CRP, TNFRSF11B, TNFSF11
46creatinine458.9CRP, TNFRSF11B, TNFSF11
47cycloheximide458.8TNFRSF11B, CRP, TNFSF11
48testosterone45 61 24 1111.8CRP, TNFSF11, TNFRSF11B
49vegf458.8TNFSF11, CRP, TNFRSF11B
50urea45 24 1110.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:0056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Apical Periodontitis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet