MCID: CHR013
MIFTS: 34

Chronic Apical Periodontitis malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Chronic Apical Periodontitis

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MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and artery disease. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Chronic Apical Periodontitis

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Chronic Apical Periodontitis, Aliases & Descriptions:

Name: Chronic Apical Periodontitis 8 10 62
 
Chronic Apical Periodontitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:11269
ICD9CM27 522.6
ICD1025 K04.5

Related Diseases for Chronic Apical Periodontitis

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Diseases in the Chronic Apical Periodontitis family:

Acute Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.2TNFRSF11B, TNFSF11
2artery disease10.4
3periapical granuloma10.3TNFSF11
4atherosclerosis10.2
5ossifying fibroma10.2
6fibroma10.2
7paresthesia10.2
8uremia10.1CRP, TNFRSF11B
9osteomyelitis10.0CRP, TNFSF11
10paget disease, juvenile10.0TNFRSF11B, TNFSF11
11polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11B, TNFSF11
12osteosclerosis10.0TNFRSF11B, TNFSF11
13aortic valve stenosis10.0TNFSF11, TNFRSF11B
14periodontal disease10.0CRP, TNFSF11
15gingivitis10.0TNFSF11, TNFRSF11B
16beta thalassemia10.0TNFSF11, TNFRSF11B
17giant cell tumor10.0TNFSF11, TNFRSF11B
18osteoporosis, postmenopausal10.0TNFSF11, TNFRSF11B
19ameloblastoma10.0TNFRSF11B, TNFSF11
20cholesteatoma10.0TNFSF11, TNFRSF11B
21osteopetrosis10.0TNFSF11, TNFRSF11B
22bone cancer10.0TNFSF11, TNFRSF11B
23hyperparathyroidism9.9TNFSF11, TNFRSF11B
24hypercalcemia9.9TNFSF11, TNFRSF11B
25secondary syphilis9.9TNFSF11, TNFRSF11B
26acute myocardial infarction9.9CRP, TNFSF11
27multiple myeloma9.9TNFSF11, TNFRSF11B
28myeloma9.8TNFRSF11B, TNFSF11
29psoriatic arthritis9.8TNFRSF11B, CRP, TNFSF11
30osteoporosis9.8TNFRSF11B, TNFSF11
31ankylosing spondylitis9.8TNFRSF11B, TNFSF11, CRP
32arthropathy9.8TNFRSF11B, TNFSF11, CRP
33rheumatic disease9.8TNFSF11, TNFRSF11B, CRP
34synovitis9.8TNFRSF11B, CRP, TNFSF11
35vascular disease9.8TNFRSF11B, TNFSF11, CRP
36coronary artery anomaly9.8TNFSF11, CRP, TNFRSF11B
37chronic kidney failure9.8CRP, TNFSF11, TNFRSF11B
38osteoarthritis9.8TNFSF11, TNFRSF11B, CRP
39arthritis9.8CRP, TNFSF11, TNFRSF11B
40primary hyperoxaluria9.8TNFSF11, TNFRSF11B, CRP
41ulcerative colitis9.8TNFSF11, CRP
42rheumatoid arthritis9.7TNFSF11, TNFRSF11B, CRP

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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MalaCards organs/tissues related to Chronic Apical Periodontitis:

32
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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Publications for Chronic Apical Periodontitis

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Articles related to Chronic Apical Periodontitis:

(show all 21)
idTitleAuthorsYear
1
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
2
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
3
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
4
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
5
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
6
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
7
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
8
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
9
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
10
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
11
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
12
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
13
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
14
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
15
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
16
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
17
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
18
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
19
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
20
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
21
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Expression patterns in normal tissues for genes affiliated with Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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Pathways related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CRP, TNFSF11
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFRSF11B, TNFSF11
49.0TNFRSF11B, TNFSF11
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling60
9.0TNFSF11, TNFRSF11B
79.0TNFRSF11B, TNFSF11
89.0TNFRSF11B, TNFSF11
99.0TNFRSF11B, TNFSF11

Compounds for genes affiliated with Chronic Apical Periodontitis

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Compounds related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra44 1110.7TNFRSF11B, CRP
2nitroglycerin44 1110.7CRP, TNFRSF11B
3p005449.7CRP, TNFRSF11B
4p003449.5CRP, TNFRSF11B
5hcc-1449.5TNFRSF11B, TNFSF11
6denosumab44 1110.5TNFRSF11B, TNFSF11
7teriparatide44 1110.5TNFRSF11B, TNFSF11
8ibandronate44 1110.5TNFSF11, TNFRSF11B
9polyethylene449.5TNFSF11, TNFRSF11B
10vitamin k2449.4TNFRSF11B, TNFSF11
11homocysteine44 2410.4CRP, TNFRSF11B
12risedronate44 50 28 61 1113.4TNFRSF11B, TNFSF11
13clodronate44 50 1111.4TNFRSF11B, TNFSF11
14geranylgeranyl pyrophosphate449.4TNFRSF11B, TNFSF11
15titanium449.4TNFRSF11B, TNFSF11
16zoledronic acid449.4TNFSF11, TNFRSF11B
17polymyxin b449.4TNFSF11, TNFRSF11B
18alendronate44 50 1111.4TNFRSF11B, TNFSF11
19p002449.4CRP, TNFRSF11B
20ns 39844 6110.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4TNFRSF11B, TNFSF11
22phosphorus449.4TNFRSF11B, TNFSF11
23raloxifene44 50 28 1112.4TNFRSF11B, TNFSF11
24mevalonate449.3TNFSF11, TNFRSF11B
25latex449.3CRP, TNFSF11
26atorvastatin44 50 28 24 1113.3TNFRSF11B, CRP
27hydroxyapatite449.3TNFRSF11B, TNFSF11
28dhea449.3TNFSF11, TNFRSF11B
29celecoxib44 61 28 50 24 1114.3TNFRSF11B, TNFSF11
30procollagen449.3TNFSF11, TNFRSF11B
31gp 130449.3TNFRSF11B, TNFSF11
32prednisolone44 28 1111.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3449.2TNFSF11, TNFRSF11B
34heparan sulfate44 2410.0TNFRSF11B, TNFSF11
35pamidronate44 50 1111.0CRP, TNFRSF11B, TNFSF11
36pmma449.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline449.0TNFSF11, TNFRSF11B, CRP
3825-hydroxyvitamin d449.0CRP, TNFRSF11B, TNFSF11
39etanercept44 50 1111.0TNFSF11, TNFRSF11B, CRP
40infliximab44 50 1110.9CRP, TNFRSF11B, TNFSF11
41azathioprine44 2 50 1111.9TNFSF11, TNFRSF11B, CRP
42methotrexate50 44 1110.9CRP, TNFRSF11B, TNFSF11
43ascorbic acid44 249.9CRP, TNFRSF11B, TNFSF11
44sb 20358044 619.9TNFSF11, TNFRSF11B, CRP
45ly294002448.9TNFSF11, TNFRSF11B, CRP
46creatinine448.9CRP, TNFRSF11B, TNFSF11
47cycloheximide448.8TNFSF11, TNFRSF11B, CRP
48testosterone44 61 24 1111.8CRP, TNFRSF11B, TNFSF11
49vegf448.8CRP, TNFRSF11B, TNFSF11
50urea44 24 1110.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

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Cellular components related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:0056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

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Sources for Chronic Apical Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet