MCID: CHR013
MIFTS: 28

Chronic Apical Periodontitis malady

Gastrointestinal diseases category

Aliases & Classifications for Chronic Apical Periodontitis

About this section

Aliases & Descriptions for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 8 10 61
 
Chronic Apical Periodontitis Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:11269
ICD9CM27 522.6
ICD1025 K04.5

Summaries for Chronic Apical Periodontitis

About this section
MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and coronary artery disease. An important gene associated with Chronic Apical Periodontitis is VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)), and among its related pathways are IL6-mediated signaling events and TRAF Pathway. The compounds anakinra and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

About this section

Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.3TNFRSF11B, TNFSF11
2coronary artery disease30.2TNFSF11, TNFRSF11B, CRP
3artery disease10.4
4periapical granuloma10.3TNFSF11
5atherosclerosis10.2
6ossifying fibroma10.2
7fibroma10.2
8root resorption10.2
9paresthesia10.2
10uremia10.1CRP, TNFRSF11B
11osteomyelitis10.0TNFSF11, CRP
12lipid metabolism disorder10.0TNFRSF11B, CRP
13osteolysis, familial expansile10.0TNFRSF11B, TNFSF11
14paget disease, juvenile10.0TNFRSF11B, TNFSF11
15hyperostosis, endosteal10.0TNFRSF11B, TNFSF11
16marchiafava bignami disease10.0TNFSF11, TNFRSF11B
17aortic valve disease 210.0TNFRSF11B, TNFSF11
18periodontal disease10.0CRP, TNFSF11
19gingivitis10.0TNFSF11, TNFRSF11B
20thalassemia, hispanic gamma-delta-beta10.0TNFSF11, TNFRSF11B
21giant cell tumor10.0TNFSF11, TNFRSF11B
22ameloblastoma10.0TNFRSF11B, TNFSF11
23cholesteatoma10.0TNFSF11, TNFRSF11B
24osteopetrosis10.0TNFRSF11B, TNFSF11
25bone cancer10.0TNFSF11, TNFRSF11B
26hyperparathyroidism9.9TNFRSF11B, TNFSF11
27hypercalcemia9.9TNFSF11, TNFRSF11B
28secondary syphilis9.9TNFRSF11B, TNFSF11
29acute myocardial infarction9.9CRP, TNFSF11
30multiple myeloma9.9TNFRSF11B, TNFSF11
31myeloma9.8TNFRSF11B, TNFSF11
32psoriatic arthritis9.8CRP, TNFRSF11B, TNFSF11
33spondyloarthropathy 19.8CRP, TNFRSF11B, TNFSF11
34arthropathy9.8TNFSF11, TNFRSF11B, CRP
35osteoporosis9.8TNFRSF11B, TNFSF11
36rheumatic disease9.8CRP, TNFRSF11B, TNFSF11
37synovitis9.8CRP, TNFRSF11B, TNFSF11
38vascular disease9.8TNFSF11, TNFRSF11B, CRP
39chronic kidney failure9.8CRP, TNFRSF11B, TNFSF11
40osteoarthritis9.8CRP, TNFRSF11B, TNFSF11
41arthritis9.8CRP, TNFRSF11B, TNFSF11
42primary hyperoxaluria9.8TNFSF11, TNFRSF11B, CRP
43ulcerative colitis9.7CRP, TNFSF11
44rheumatoid arthritis9.7CRP, TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

About this section

Drugs & Therapeutics for Chronic Apical Periodontitis

About this section

Drug clinical trials:

Search ClinicalTrials for Chronic Apical Periodontitis

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

About this section

Anatomical Context for Chronic Apical Periodontitis

About this section

MalaCards organs/tissues related to Chronic Apical Periodontitis:

31
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

About this section

Publications for Chronic Apical Periodontitis

About this section

Articles related to Chronic Apical Periodontitis:

(show all 23)
idTitleAuthorsYear
1
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. (25826508)
2015
2
Association between chronic apical periodontitis and low-birth-weight preterm births. (25576210)
2015
3
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
4
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
5
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
6
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
7
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
8
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
9
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
10
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
11
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
12
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
13
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
14
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
15
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
16
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
17
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
18
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
19
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
20
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
21
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
22
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
23
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

About this section

Expression for genes affiliated with Chronic Apical Periodontitis

About this section
Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

About this section

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CRP, TNFSF11
2
Show member pathways
9.0TNFRSF11B, TNFSF11
3
Show member pathways
9.0TNFRSF11B, TNFSF11
49.0TNFRSF11B, TNFSF11
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0TNFRSF11B, TNFSF11
6
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling59
9.0TNFSF11, TNFRSF11B
79.0TNFRSF11B, TNFSF11
89.0TNFRSF11B, TNFSF11
99.0TNFRSF11B, TNFSF11

Compounds for genes affiliated with Chronic Apical Periodontitis

About this section

Compounds related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1anakinra44 1110.7TNFRSF11B, CRP
2nitroglycerin44 1110.7CRP, TNFRSF11B
3p005449.7CRP, TNFRSF11B
4p003449.5TNFRSF11B, CRP
5hcc-1449.5TNFSF11, TNFRSF11B
6denosumab44 1110.5TNFRSF11B, TNFSF11
7teriparatide44 1110.5TNFRSF11B, TNFSF11
8ibandronate44 1110.5TNFRSF11B, TNFSF11
9polyethylene449.5TNFRSF11B, TNFSF11
10vitamin k2449.4TNFRSF11B, TNFSF11
11homocysteine44 2410.4TNFRSF11B, CRP
12risedronate44 50 28 60 1113.4TNFSF11, TNFRSF11B
13clodronate44 50 1111.4TNFSF11, TNFRSF11B
14geranylgeranyl pyrophosphate449.4TNFSF11, TNFRSF11B
15titanium449.4TNFSF11, TNFRSF11B
16polymyxin b449.4TNFSF11, TNFRSF11B
17zoledronic acid449.4TNFSF11, TNFRSF11B
18alendronate44 50 1111.4TNFSF11, TNFRSF11B
19p002449.4TNFRSF11B, CRP
20ns 39844 6010.4TNFSF11, TNFRSF11B
213-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4TNFSF11, TNFRSF11B
22phosphorus449.4TNFSF11, TNFRSF11B
23raloxifene44 50 28 1112.4TNFSF11, TNFRSF11B
24mevalonate449.3TNFRSF11B, TNFSF11
25latex449.3CRP, TNFSF11
26prednisolone44 28 1111.3TNFRSF11B, CRP
27hydroxyapatite449.3TNFSF11, TNFRSF11B
28dhea449.3TNFRSF11B, TNFSF11
29celecoxib44 60 28 50 24 1114.3TNFRSF11B, TNFSF11
30procollagen449.3TNFSF11, TNFRSF11B
31gp 130449.3TNFSF11, TNFRSF11B
32atorvastatin44 50 28 24 1113.2TNFRSF11B, CRP
331,25 dihydroxy vitamin d3449.2TNFSF11, TNFRSF11B
34heparan sulfate44 2410.0TNFSF11, TNFRSF11B
35pamidronate44 50 1111.0CRP, TNFRSF11B, TNFSF11
36pmma449.0CRP, TNFRSF11B, TNFSF11
37deoxypyridinoline449.0CRP, TNFSF11, TNFRSF11B
3825-hydroxyvitamin d449.0CRP, TNFSF11, TNFRSF11B
39etanercept44 50 1111.0TNFSF11, TNFRSF11B, CRP
40infliximab44 50 1110.9TNFSF11, CRP, TNFRSF11B
41azathioprine44 1 50 1111.9CRP, TNFSF11, TNFRSF11B
42methotrexate50 44 1110.9TNFRSF11B, CRP, TNFSF11
43ascorbic acid44 249.9CRP, TNFRSF11B, TNFSF11
44sb 20358044 609.9CRP, TNFSF11, TNFRSF11B
45ly294002448.9CRP, TNFRSF11B, TNFSF11
46creatinine448.9CRP, TNFRSF11B, TNFSF11
47cycloheximide448.8TNFRSF11B, CRP, TNFSF11
48testosterone44 60 24 1111.8CRP, TNFSF11, TNFRSF11B
49vegf448.8TNFSF11, CRP, TNFRSF11B
50urea44 24 1110.7TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Chronic Apical Periodontitis

About this section

Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5CRP, TNFRSF11B, TNFSF11
2extracellular spaceGO:00056158.2CRP, TNFRSF11B, TNFSF11

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0TNFRSF11B, TNFSF11

Sources for Chronic Apical Periodontitis

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet