MCID: CHR013
MIFTS: 30

Chronic Apical Periodontitis malady

Gastrointestinal diseases category

Summaries for Chronic Apical Periodontitis

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MalaCards: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and ossifying fibroma. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (tumor necrosis factor receptor superfamily, member 11b), and among its related pathways are TWEAK Pathway and TRAF Pathway. The compounds hcc-1 and denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Chronic Apical Periodontitis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

chronic apical periodontitis 8 10 60
chronic apical periodontitis nos 8


External Ids:

Disease Ontology8 DOID:11269
ICD9CM27 522.6
ICD1025 K04.5

Related Diseases for Chronic Apical Periodontitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.2TNFRSF11B, TNFSF11
2ossifying fibroma10.2
3acute apical periodontitis10.2
4atherosclerosis10.2
5psoriatic arthritis10.0CRP
6rheumatic disease10.0CRP
7ankylosing spondylitis10.0CRP
8carotid stenosis10.0CRP
9peritonitis10.0CRP
10root resorption10.0TNFRSF11B
11hyperphosphatemia10.0TNFRSF11B
12renal osteodystrophy10.0TNFRSF11B
13crohn's disease10.0CRP
14galactosemia10.0CRP
15cystic fibrosis10.0TNFRSF11B
16primary hyperoxaluria10.0TNFRSF11B
17myocardial infarction10.0CRP
18familial mediterranean fever10.0CRP
19periapical granuloma10.0TNFSF11
20diabetes mellitus10.0CRP
21giant cell tumor10.0TNFSF11
22periodontal disease10.0TNFSF11, CRP
23acute myocardial infarction10.0TNFSF11, CRP
24paget disease, juvenile10.0TNFSF11, TNFRSF11B
25polyostotic osteolytic dysplasia, hereditary expansile10.0TNFSF11, TNFRSF11B
26hypercalcemia10.0TNFSF11, TNFRSF11B
27osteomyelitis10.0TNFSF11, CRP
28aortic valve stenosis10.0TNFRSF11B, TNFSF11
29beta thalassemia10.0TNFSF11, TNFRSF11B
30adenoameloblastoma10.0TNFSF11, TNFRSF11B
31osteoporosis, postmenopausal10.0TNFSF11, TNFRSF11B
32osteosclerosis10.0TNFRSF11B, TNFSF11
33bone carcinoma10.0TNFSF11, TNFRSF11B
34gingivitis10.0TNFSF11, TNFRSF11B
35secondary syphilis10.0TNFRSF11B, TNFSF11
36uremia10.0CRP, TNFRSF11B
37osteopetrosis10.0TNFSF11, TNFRSF11B
38cholesteatoma10.0TNFRSF11B, TNFSF11
39multiple myeloma10.0TNFRSF11B, TNFSF11
40arthropathy10.0TNFSF11, TNFRSF11B, CRP
41synovitis10.0CRP, TNFRSF11B, TNFSF11
42vascular disease10.0TNFSF11, TNFRSF11B, CRP
43osteoporosis10.0TNFRSF11B, TNFSF11
44coronary artery disease10.0CRP, TNFRSF11B, TNFSF11
45chronic kidney failure10.0CRP, TNFRSF11B, TNFSF11
46osteoarthritis10.0CRP, TNFRSF11B, TNFSF11
47myeloma10.0TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Clinical Features for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Apical Periodontitis

Drug clinical trials:

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Search NIH Clinical Center for Chronic Apical Periodontitis

Search CenterWatch for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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32MalaCards
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MalaCards organs/tissues related to Chronic Apical Periodontitis:

32
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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Publications for Chronic Apical Periodontitis

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50PubMed
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Articles related to Chronic Apical Periodontitis:

(show all 18)
idTitleAuthorsYear
1
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
2
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
3
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
4
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
5
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
6
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
7
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
8
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
9
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
10
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
11
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
12
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
13
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
14
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
15
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
16
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
17
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
18
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Genetic Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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Sources:
51QIAGEN, 55SinoBiological, 52R&D Systems, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Chronic Apical Periodontitis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1hcc-1449.8TNFRSF11B, TNFSF11
2denosumab44 1110.8TNFRSF11B, TNFSF11
3teriparatide44 1110.8TNFRSF11B, TNFSF11
4polyethylene449.8TNFSF11, TNFRSF11B
5ibandronate44 1110.8TNFSF11, TNFRSF11B
6vitamin k2449.7TNFSF11, TNFRSF11B
7risedronate44 59 49 28 1113.7TNFRSF11B, TNFSF11
8clodronate44 49 1111.7TNFRSF11B, TNFSF11
9geranylgeranyl pyrophosphate449.7TNFRSF11B, TNFSF11
10titanium449.7TNFRSF11B, TNFSF11
11polymyxin b449.7TNFSF11, TNFRSF11B
12zoledronic acid449.7TNFSF11, TNFRSF11B
13alendronate44 49 1111.7TNFRSF11B, TNFSF11
14ns 39844 5910.7TNFRSF11B, TNFSF11
153-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7TNFSF11, TNFRSF11B
16phosphorus449.7TNFRSF11B, TNFSF11
17raloxifene44 28 49 1112.7TNFRSF11B, TNFSF11
18mevalonate449.6TNFSF11, TNFRSF11B
19hydroxyapatite449.6TNFSF11, TNFRSF11B
20dhea449.6TNFRSF11B, TNFSF11
21celecoxib44 59 28 49 11 2414.6TNFRSF11B, TNFSF11
22procollagen449.6TNFRSF11B, TNFSF11
23anakinra44 1110.6CRP, TNFRSF11B
24gp 130449.5TNFRSF11B, TNFSF11
25nitroglycerin44 1110.5TNFRSF11B, CRP
26p005449.5CRP, TNFRSF11B
271,25 dihydroxy vitamin d3449.4TNFRSF11B, TNFSF11
28urea44 11 2411.3TNFRSF11B, TNFSF11
29p003449.3TNFRSF11B, CRP
30latex449.2CRP, TNFSF11
31homocysteine44 2410.2CRP, TNFRSF11B
32atorvastatin44 49 28 11 2413.1TNFRSF11B, CRP
33p002449.0CRP, TNFRSF11B
34pamidronate44 49 1111.0CRP, TNFRSF11B, TNFSF11
35pmma449.0CRP, TNFRSF11B, TNFSF11
36deoxypyridinoline449.0TNFSF11, TNFRSF11B, CRP
3725-hydroxyvitamin d449.0CRP, TNFRSF11B, TNFSF11
38etanercept44 49 1111.0TNFSF11, TNFRSF11B, CRP
39infliximab44 49 1110.9CRP, TNFRSF11B, TNFSF11
40azathioprine44 49 2 1111.9TNFSF11, TNFRSF11B, CRP
41methotrexate44 49 1110.9CRP, TNFRSF11B, TNFSF11
42ascorbic acid44 249.9CRP, TNFRSF11B, TNFSF11
43sb 20358044 599.9TNFSF11, TNFRSF11B, CRP
44ly294002448.9TNFSF11, TNFRSF11B, CRP
45creatinine448.8TNFSF11, TNFRSF11B, CRP
46prednisolone44 28 1110.8CRP, TNFRSF11B
47cycloheximide448.8CRP, TNFRSF11B, TNFSF11
48testosterone44 59 11 2411.8CRP, TNFRSF11B, TNFSF11
49vegf448.7TNFSF11, TNFRSF11B, CRP

GO Terms for genes affiliated with Chronic Apical Periodontitis

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16Gene Ontology
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Cellular components related to Chronic Apical Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CRP, TNFRSF11B, TNFSF11

Products for genes affiliated with Chronic Apical Periodontitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Apical Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet