MCID: CHR013
MIFTS: 31

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 14 69
Chronic Apical Periodontitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD10 32 K04.5
ICD9CM 34 522.6
UMLS 69 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and root resorption. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Osteoclast differentiation and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 periodontitis 30.9 TNFRSF11B TNFSF11
2 root resorption 30.0 TNFRSF11B TNFSF11
3 periapical periodontitis 29.6 SASS6 SLC52A2 TNFRSF11B TNFSF11
4 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11B TNFSF11
5 hemophilic arthropathy 10.2 TNFRSF11B TNFSF11
6 paget disease of bone 5, juvenile-onset 10.2 TNFRSF11B TNFSF11
7 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
8 kummell's disease 10.2 TNFRSF11B TNFSF11
9 periodontitis, chronic 10.2 TNFRSF11B TNFSF11
10 familial expansile osteolysis 10.2 TNFRSF11B TNFSF11
11 cohen-gibson syndrome 10.2 TNFRSF11B TNFSF11
12 multicentric carpotarsal osteolysis syndrome 10.2 TNFRSF11B TNFSF11
13 tooth resorption 10.2 TNFRSF11B TNFSF11
14 glucocorticoid-induced osteoporosis 10.2 TNFRSF11B TNFSF11
15 ischemic bone disease 10.2 TNFRSF11B TNFSF11
16 endosteal hyperostosis, autosomal dominant 10.2 TNFRSF11B TNFSF11
17 bone resorption disease 10.2 TNFRSF11B TNFSF11
18 bone remodeling disease 10.2 TNFRSF11B TNFSF11
19 osteonecrosis 10.2 TNFRSF11B TNFSF11
20 spondyloarthropathy 1 10.2 TNFRSF11B TNFSF11
21 giant cell tumor 10.1 TNFRSF11B TNFSF11
22 cholesteatoma 10.1 TNFRSF11B TNFSF11
23 bone inflammation disease 10.1 TNFRSF11B TNFSF11
24 paget's disease of bone 10.1 TNFRSF11B TNFSF11
25 aortic valve disease 2 10.1 TNFRSF11B TNFSF11
26 synovitis 10.1 TNFRSF11B TNFSF11
27 arthropathy 10.0 TNFRSF11B TNFSF11
28 periodontal disease 10.0 TNFRSF11B TNFSF11
29 arteries, anomalies of 10.0
30 coronary artery anomaly 10.0
31 myeloma, multiple 9.9 TNFRSF11B TNFSF11
32 madras motor neuron disease 9.9 SLC52A2 SLC52A3
33 psoriatic arthritis 9.9 TNFRSF11B TNFSF11
34 progressive bulbar palsy 9.9 SLC52A2 SLC52A3
35 brown-vialetto-van laere syndrome 9.8 SLC52A2 SLC52A3
36 adenoiditis 9.8
37 ossifying fibroma 9.8
38 paresthesia 9.8
39 osteogenic sarcoma 9.7 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2 Racepinephrine Approved 329-65-7
3 Epinephryl borate
4
s 1 (combination)
5 Anti-Infective Agents
6 Disinfectants
7 Eusol
8 Pharmaceutical Solutions
9 Sodium hypochlorite

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
2 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
3 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1
4 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054
5 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
6 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Active, not recruiting NCT03288467

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

38
Bone

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show all 30)
# Title Authors Year
1
Dickkopf-1 may regulate bone coupling by attenuating wnt/I^-catenin signaling in chronic apical periodontitis. ( 29216526 )
2018
2
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017
3
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. ( 28455694 )
2017
4
Clinical, imagistic and histopathological study of chronic apical periodontitis. ( 27833964 )
2016
5
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. ( 27118467 )
2016
6
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. ( 25826508 )
2015
7
Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis. ( 26666260 )
2015
8
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. ( 26406018 )
2015
9
Association between chronic apical periodontitis and low-birth-weight preterm births. ( 25576210 )
2015
10
Association between chronic apical periodontitis and coronary artery disease. ( 24461397 )
2014
11
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. ( 25075670 )
2014
12
Chronic apical periodontitis is more common in subjects with coronary artery disease. ( 25234220 )
2014
13
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. ( 24172007 )
2013
14
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. ( 24338091 )
2013
15
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. ( 24068408 )
2013
16
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. ( 21933620 )
2011
17
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. ( 20951289 )
2010
18
Ossifying fibroma misdiagnosed as chronic apical periodontitis. ( 20171381 )
2010
19
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. ( 20491984 )
2010
20
[Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. ( 18278135 )
2008
21
Root canal microbiota of teeth with chronic apical periodontitis. ( 18768651 )
2008
22
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. ( 19026873 )
2008
23
The influence of chronic apical periodontitis on oral and general health. ( 18078141 )
2007
24
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. ( 16186751 )
2005
25
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. ( 15220649 )
2004
26
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. ( 11556508 )
2001
27
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. ( 9206419 )
1996
28
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. ( 9028199 )
1996
29
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. ( 8247615 )
1993
30
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. ( 6945343 )
1981

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

GO Terms for Chronic Apical Periodontitis

Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.33 IL34 TNFRSF11B TNFSF11
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.26 TNFRSF11B TNFSF11
3 riboflavin metabolic process GO:0006771 8.96 SLC52A2 SLC52A3
4 riboflavin transport GO:0032218 8.62 SLC52A2 SLC52A3

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL34 TNFRSF11B TNFSF11
2 riboflavin transmembrane transporter activity GO:0032217 8.62 SLC52A2 SLC52A3

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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