MCID: CHR013
MIFTS: 31

Chronic Apical Periodontitis malady

Gastrointestinal diseases, Oral diseases categories

Aliases & Classifications for Chronic Apical Periodontitis

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Aliases & Descriptions for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 10 12 65
 
Chronic Apical Periodontitis Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:11269
ICD9CM29 522.6
ICD1027 K04.5

Summaries for Chronic Apical Periodontitis

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MalaCards based summary: Chronic Apical Periodontitis, also known as chronic apical periodontitis nos, is related to periodontitis and coronary artery disease. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (Tumor Necrosis Factor Receptor Superfamily, Member 11b), and among its related pathways are Osteoblast Signaling and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include bone, and related mouse phenotypes are reproductive system and mortality/aging.

Related Diseases for Chronic Apical Periodontitis

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Diseases in the Acute Apical Periodontitis family:

chronic apical periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.2CXCL8, DEFB1, IL1B, TNFRSF11B, TNFSF11
2coronary artery disease10.4
3artery disease10.4
4sall4-related disorders10.3SLC52A2, SLC52A3
5richards-rundle syndrome10.3SLC52A2, SLC52A3
6mahvash disease10.3SLC52A2, SLC52A3
7paget disease of bone 2, early-onset10.3TNFRSF11B, TNFSF11
8hemorrhagic fever10.3TNFRSF11B, TNFSF11
9dyskinesia of esophagus10.3TNFRSF11B, TNFSF11
10paget disease of bone 5, juvenile-onset10.3TNFRSF11B, TNFSF11
11cholesterol embolism10.2DEFB1, TNFRSF11B, TNFSF11
12polycystic bone disease10.2TNFRSF11B, TNFSF11
13atherosclerosis10.2
14root resorption10.2
15ossifying fibroma10.2
16fibroma10.2
17paresthesia10.2
18hilar cholangiocellular carcinoma10.2SLC52A2, SLC52A3
19methylmalonic aciduria and homocystinuria type cble10.2IL1B, TNFRSF11B, TNFSF11
20protein r deficiency10.1IL1B, TNFRSF11B
21diabetic ketoacidosis10.1CXCL8, IL1B
22angiokeratoma circumscriptum10.1CCL5, CXCL8, TNFSF11
23pyeloureteritis cystica10.1CXCL8, IL15
24plantar nerve lesion10.1CXCL8, IL1B
25dermatitis10.1CXCL8, IL1B, SASS6
26multiple myeloma10.1CD38, CXCL12, TNFRSF11B, TNFSF11
27polyradiculopathy10.1CCL5, CXCL12, PRF1
28vaginal glandular tumor10.1CXCL8, IL1B, PRF1
29vascular cancer10.1CXCL8, IL1B, PRF1
30chronic mucocutaneous candidiasis10.1CXCL8, IL1B, PRF1
31otitis externa10.1CXCL8, IL1B, TNFSF11
32hydrocele10.1CCL5, CD38, CXCL12
33hyperinsulinemic hypoglycemia10.1CXCL8, DEFB1, IL1B
34splenic sequestration10.0CXCL8, DEFB1, IL1B
35synovium cancer10.0CXCL8, IL1B, TNFRSF11B, TNFSF11
36gastroesophageal reflux10.0CXCL8, IL1B, VIP
37osteochondritis dissecans10.0CXCL8, IL1B, TNFRSF11B, TNFSF11
38central pontine myelinolysis10.0CD38, IL15, IL1B
39gastroenteritis10.0CXCL8, DEFB1, IL1B
40hypoglycemic coma9.9CCL5, CXCL8, IL15
41psoriatic arthritis9.9IL15, IL1B, TNFRSF11B, TNFSF11
42tuberculosis9.9CCL5, CXCL8, IL1B
43bronchial neoplasm9.9CCL5, CXCL8, IL15
44lymphoma, non-hodgkin9.9CD38, CXCL12, IL15, PRF1
45periostitis9.9CXCL8, DEFB1, IL1B, TNFRSF11B, TNFSF11
46pericardial effusion9.9IL1B, SASS6, SLC52A2, SLC52A3, TNFRSF11B, TNFSF11
47interstitial nephritis9.9CCL5, CXCL8, IL1B
48salivary gland cancer9.9CCL5, CXCL8, VIP
49microphthalmia9.9B3GAT1, CCL5, CXCL12, CXCL8
50pharyngitis9.9CCL5, CXCL8

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to chronic apical periodontitis

Symptoms for Chronic Apical Periodontitis

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Drugs & Therapeutics for Chronic Apical Periodontitis

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Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EpinephrineapprovedPhase 476851-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2RacepinephrinePhase 4768
3Epinephryl boratePhase 4768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic TherapyRecruitingNCT01532674Phase 4
2Longitudinal Endodontic Study of Apical Preparation SizeCompletedNCT00223379
3Cytokine Regulation of Periradicular Pain in HumansCompletedNCT00223470
4Measurement of Bite Force in HumansCompletedNCT00223327Phase 0
5Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal PocketsCompletedNCT02531555
6Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs PeriodontitisCompletedNCT02664675

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

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Anatomical Context for Chronic Apical Periodontitis

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MalaCards organs/tissues related to Chronic Apical Periodontitis:

33
Bone

Animal Models for Chronic Apical Periodontitis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Apical Periodontitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.1CXCL12, FLT4, IL15, MDK, NRG1, PRF1
2MP:00107686.8CXCL12, DEFB1, FLT4, IL15, IL1B, NRG1
3MP:00053875.5CCL5, CD38, CXCL12, CXCL8, DEFB1, FLT4
4MP:00053975.4CCL5, CD38, CXCL12, CXCL8, FGF1, IL15

Publications for Chronic Apical Periodontitis

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Articles related to Chronic Apical Periodontitis:

(show all 24)
idTitleAuthorsYear
1
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. (25826508)
2015
2
Association between chronic apical periodontitis and low-birth-weight preterm births. (25576210)
2015
3
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. (26406018)
2015
4
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. (25075670)
2014
5
Association between chronic apical periodontitis and coronary artery disease. (24461397)
2014
6
Chronic apical periodontitis is more common in subjects with coronary artery disease. (25234220)
2014
7
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. (24068408)
2013
8
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. (24172007)
2013
9
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. (24338091)
2013
10
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
11
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
12
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. (20951289)
2010
13
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
14
Root canal microbiota of teeth with chronic apical periodontitis. (18768651)
2008
15
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. (19026873)
2008
16
Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. (18278135)
2008
17
The influence of chronic apical periodontitis on oral and general health. (18078141)
2007
18
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. (16186751)
2005
19
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. (15220649)
2004
20
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. (11556508)
2001
21
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. (9028199)
1996
22
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. (9206419)
1996
23
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. (8247615)
1993
24
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981

Variations for Chronic Apical Periodontitis

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Expression for genes affiliated with Chronic Apical Periodontitis

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Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for genes affiliated with Chronic Apical Periodontitis

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GO Terms for genes affiliated with Chronic Apical Periodontitis

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Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.2CCL5, CXCL12, CXCL8, DEFB1, FGF1, IL15
2extracellular regionGO:00055764.6CCL5, CXCL12, CXCL8, DEFB1, FGF1, FLT4

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1riboflavin transportGO:003221810.8SLC52A2, SLC52A3
2negative regulation of bone resorptionGO:004577910.6CD38, TNFRSF11B
3positive regulation of protein kinase C signalingGO:009003710.6FLT4, WNT5A
4positive regulation of homotypic cell-cell adhesionGO:003411210.5CCL5, TNFSF11
5positive regulation of intracellular signal transductionGO:190253310.4FGF1, TNFSF11
6positive regulation of T cell chemotaxisGO:001082010.4CCL5, WNT5A
7positive regulation of chemokine biosynthetic processGO:004508010.4IL1B, WNT5A
8ameboidal-type cell migrationGO:000166710.3CXCL12, WNT5A
9positive regulation of fever generationGO:003162210.1CCL5, IL1B
10cellular response to lipidGO:007139610.1CCL5, IL1B
11induction of positive chemotaxisGO:005093010.1CXCL12, CXCL8
12positive regulation of monocyte chemotaxisGO:009002610.1CCL5, CXCL12
13positive regulation of T cell migrationGO:200040610.1CCL5, CXCL12
14negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.1CCL5, CXCL8
15neutrophil activationGO:004211910.0CCL5, CXCL8
16positive regulation of inflammatory responseGO:00507299.8CCL5, IL15, WNT5A
17positive regulation of epithelial cell proliferationGO:00506799.8CCL5, FGF1, WNT5A
18positive regulation of cell adhesionGO:00457859.7CCL5, CXCL12, NRG1
19chemokine-mediated signaling pathwayGO:00700989.6CCL5, CXCL12, CXCL8
20positive regulation of endothelial cell proliferationGO:00019389.6CXCL12, FLT4, VIP, WNT5A
21neutrophil chemotaxisGO:00305939.5CCL5, CXCL8, IL1B
22positive regulation of JNK cascadeGO:00463309.4FLT4, IL1B, TNFSF11, WNT5A
23wound healingGO:00420609.4IL1B, NRG1, WNT5A
24chemotaxisGO:00069359.4CCL5, CXCL12, CXCL8, DEFB1
25cellular response to lipopolysaccharideGO:00712229.3CCL5, CXCL8, IL1B, WNT5A
26positive regulation of T cell proliferationGO:00421029.3CCL5, IL15, IL1B
27positive regulation of protein phosphorylationGO:00019349.3FGF1, FLT4, IL1B, WNT5A
28response to glucocorticoidGO:00513849.2CCL5, IL1B, MDK
29inflammatory responseGO:00069548.8CCL5, CXCL8, IL15, IL1B, TNFRSF11B
30positive regulation of ERK1 and ERK2 cascadeGO:00703748.8CCL5, FGF1, FLT4, IL1B
31MAPK cascadeGO:00001658.7CCL5, FGF1, IL1B, NRG1
32positive regulation of angiogenesisGO:00457668.6CCL5, CXCL8, FGF1, IL1B, WNT5A
33response to drugGO:00424938.3CCL5, CD38, IL1B, MDK, TNFRSF11B
34positive regulation of cell proliferationGO:00082848.3CXCL12, FGF1, FLT4, IL15, VIP, WNT5A
35immune responseGO:00069557.9CCL5, CXCL12, CXCL8, DEFB1, IL15, IL1B
36signal transductionGO:00071656.8CD38, CXCL12, CXCL8, FGF1, IL15, IL1B

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1riboflavin transporter activityGO:003221710.6SLC52A2, SLC52A3
2chemokine receptor bindingGO:00423799.7CCL5, CXCL12
3chemokine activityGO:00080099.2CCL5, CXCL12, CXCL8
4cytokine activityGO:00051258.8IL15, IL1B, NRG1, TNFRSF11B, TNFSF11, WNT5A
5growth factor activityGO:00080838.0CXCL12, FGF1, MDK, NRG1

Sources for Chronic Apical Periodontitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet