MCID: CHR086
MIFTS: 44

Chronic Conjunctivitis

Categories: Infectious diseases, Eye diseases, Cardiovascular diseases, Respiratory diseases, Gastrointestinal diseases, Nephrological diseases

Aliases & Classifications for Chronic Conjunctivitis

MalaCards integrated aliases for Chronic Conjunctivitis:

Name: Chronic Conjunctivitis 12 51 14 69
Chronic Conjunctivitis, Unspecified 12
Unspecified Chronic Conjunctivitis 12
Chronic Conjunctivitis Nos 12

Classifications:



Summaries for Chronic Conjunctivitis

MalaCards based summary : Chronic Conjunctivitis, also known as chronic conjunctivitis, unspecified, is related to allergic conjunctivitis and conjunctivitis. An important gene associated with Chronic Conjunctivitis is FCER2 (Fc Fragment Of IgE Receptor II), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Iodine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and kidney, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis

Diseases related to Chronic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 allergic conjunctivitis 30.9 CCL11 IL13 IL4 IL5 RNASE3
2 conjunctivitis 30.2 CCL11 IL13 IL4 IL5 RNASE3
3 scleritis 29.8 IL4 IL5
4 dermatitis 27.8 CCL11 CMA1 IL13 IL4 IL5 RNASE3
5 asthma 27.6 CCL11 CCL5 FCER2 IL13 IL4 IL5
6 dermatitis, atopic 27.0 CCL11 CCL5 CMA1 FCER2 IL13 IL4
7 simple chronic conjunctivitis 12.0
8 persistent polyclonal b-cell lymphocytosis 10.4 FCER2 IL4
9 loeffler endocarditis 10.4 IL5 RNASE3
10 cytokine deficiency 10.4 IL13 IL5
11 pemphigoid gestationis 10.4 CCL11 IL5
12 papillary conjunctivitis 10.4 CCL11 IL4
13 chronic meningitis 10.4 CCL11 IL5
14 penicillin allergy 10.4 IL13 IL4
15 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL13 IL5
16 cow milk allergy 10.4 IL5 RNASE3
17 giant papillary conjunctivitis 10.4 CCL11 IL4
18 beta-lactam allergy 10.3 IL13 IL4
19 egg allergy 10.3 IL4 IL5
20 blepharitis 10.3 CCL11 IL4
21 trichinosis 10.3 IL4 IL5
22 non-suppurative otitis media 10.3 IL4 IL5
23 nut allergy 10.3 IL13 IL5
24 sinusitis 10.3 IL5 RNASE3
25 night blindness, congenital stationary, type 1a 10.3 IL13 IL5
26 vulvovaginitis 10.3 CCL11 CCL5
27 maxillary sinusitis 10.3 CCL5 RNASE3
28 radiation cystitis 10.3 IL13 IL5
29 african tick-bite fever 10.3 CCL5 IL13
30 cellulitis 10.2 IL5 RNASE3
31 ascaris lumbricoides infection 10.2 IL5 TSLP
32 eosinophilic gastroenteritis 10.2 CCL11 IL5 RNASE3
33 otitis media 10.2 CCL11 IL4 RNASE3
34 primary amebic meningoencephalitis 10.2 IL4 IL5
35 paragonimiasis 10.2 IL13 IL5 RNASE3
36 cold urticaria 10.2 CMA1 RNASE3
37 bronchitis 10.2 CCL11 IL5 RNASE3
38 pollen allergy 10.2 IL13 IL5 RNASE3
39 strongyloidiasis 10.2 CCL11 IL13 IL5
40 cough variant asthma 10.2 IL4 IL5 RNASE3
41 atopic keratoconjunctivitis 10.2 IL4 IL5 RNASE3
42 toxic oil syndrome 10.2 FCER2 IL4 IL5
43 bullous pemphigoid 10.2 CCL11 IL5 RNASE3
44 milk allergy 10.2 IL4 IL5 RNASE3
45 apple allergy 10.2 IL13 IL4 IL5
46 intestinal schistosomiasis 10.2 IL13 IL4 IL5
47 chronic tic disorder 10.2 IL13 IL4 IL5
48 orofacial granulomatosis 10.2 CCL5 IL4
49 enterobiasis 10.1 IL13 IL4 IL5
50 wells syndrome 10.1 IL5 RNASE3

Comorbidity relations with Chronic Conjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Chronic Conjunctivitis:



Diseases related to Chronic Conjunctivitis

Symptoms & Phenotypes for Chronic Conjunctivitis

MGI Mouse Phenotypes related to Chronic Conjunctivitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL11 CCL5 CMA1 FCER2 IL13 IL4
2 immune system MP:0005387 9.32 PTGER3 TNFSF4 TSLP CCL11 CCL5 CMA1

Drugs & Therapeutics for Chronic Conjunctivitis

Drugs for Chronic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 Anti-Infective Agents
3 Anti-Infective Agents, Local
4 cadexomer iodine
5 Micronutrients
6 Trace Elements

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
2 Investigation of Chronic Inflammatory Processes in Male Individuals With Hypohidrotic Ectodermal Dysplasia Completed NCT01308333

Search NIH Clinical Center for Chronic Conjunctivitis

Genetic Tests for Chronic Conjunctivitis

Anatomical Context for Chronic Conjunctivitis

MalaCards organs/tissues related to Chronic Conjunctivitis:

38
Eye, Thyroid, Kidney

Publications for Chronic Conjunctivitis

Articles related to Chronic Conjunctivitis:

(show top 50) (show all 51)
# Title Authors Year
1
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. ( 28845328 )
2017
2
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis. ( 28095628 )
2017
3
Successful Treatment with Chronic Conjunctivitis: Removal of Tarsoconjunctival Crypt. ( 27478360 )
2016
4
IgG4-related Disease Masquerading as Recurrent Scleritis and Chronic Conjunctivitis. ( 25548981 )
2015
5
Chronic Conjunctivitis and "Warts". ( 26180942 )
2015
6
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. ( 26560164 )
2015
7
A novel case of chronic conjunctivitis in a 58-year-old woman caused by Raoultella. ( 24865691 )
2014
8
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. ( 24892274 )
2014
9
A 37-year-old man referred for assistance with persistent asthma, atopic dermatitis, and chronic conjunctivitis. ( 24679732 )
2014
10
Insight into behavior of epithelial cells of the feline conjunctiva in chronic conjunctivitis as a possible limitation in detection of Chlamydophila spp. ( 25286651 )
2014
11
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. ( 23212114 )
2013
12
Antibiotic susceptibility of staphylococci isolates from patients with chronic conjunctivitis: including associated factors and clinical evaluation. ( 23944906 )
2013
13
Chronic conjunctivitis due to Mycobacterium tuberculosis. ( 23928944 )
2013
14
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. ( 23269857 )
2012
15
Chronic conjunctivitis related to phthiriasis palpebrarum. ( 22707338 )
2012
16
Real-time PCR detection of Mycoplasma felis in domestic cats suffering from chronic conjunctivitis (Poland). ( 22439345 )
2011
17
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. ( 20523096 )
2010
18
Feline herpesvirus 1 and Chlamydophila felis prevalence in cats with chronic conjunctivitis. ( 20731196 )
2010
19
A Case of Chronic Conjunctivitis following Rituximab Therapy. ( 19946424 )
2009
20
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17305744 )
2007
21
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17651461 )
2007
22
Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis. ( 16783155 )
2006
23
Vasomotor (perennial chronic) conjunctivitis. ( 16954789 )
2006
24
Isolated chronic conjunctivitis due to storage mite allergy. ( 16729793 )
2006
25
Prevalence of trachoma in chronic conjunctivitis, Birjand, Islamic Republic of Iran. ( 15339124 )
2002
26
Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. ( 11148813 )
2000
27
Chronic conjunctivitis due to lacrimal system blockage relieved by dacryocystorhinostomy. ( 11116711 )
2000
28
[Measurement of total IgE in tears : the adaptation of an immunoenzyme technique and the value of investigating locally produced IgE in the diagnosis of chronic conjunctivitis]. ( 10432371 )
1999
29
Conjunctival lymphoma masquerading as chronic conjunctivitis. ( 10201599 )
1999
30
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]. ( 9759406 )
1998
31
Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants. ( 9006422 )
1997
32
Conjunctival scrapings and impression cytology in chronic conjunctivitis. Correlation with microbiology. ( 9101190 )
1997
33
Bilateral chronic conjunctivitis and corneal scarring in a boy with X-linked hypogammaglobulinaemia. ( 8933411 )
1996
34
Chronic conjunctivitis in infants and children. ( 8414690 )
1993
35
Clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983-1991). ( 8226238 )
1993
36
Chronic conjunctivitis caused by oral anaerobes and effectively treated with systemic metronidazole plus amoxicillin. ( 1890173 )
1991
37
A systemic approach to the diagnosis of chronic conjunctivitis. ( 2378391 )
1990
38
A systematic approach to the diagnosis and treatment of chronic conjunctivitis. ( 2154106 )
1990
39
Tear film flow and stability in acute and chronic conjunctivitis. ( 3618153 )
1987
40
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. ( 6431741 )
1984
41
Chronic conjunctivitis associated with 'floppy eyelids'. ( 6651592 )
1983
42
Laboratory studies in chronic conjunctivitis. ( 6660697 )
1983
43
Development of chronic conjunctivitis with scarring and pannus, resembling trachoma, in guinea-pigs. ( 7387962 )
1980
44
Clinical trial of the topical use of disodium cromoglycate in vernal, allergic and chronic conjunctivitis. ( 6773293 )
1980
45
Observations on conjunctival neoplasms masquerading as chronic conjunctivitis or keratitis. ( 5357353 )
1969
46
Conjunctival carcinoma masquerading as chronic conjunctivitis. ( 6064087 )
1967
47
Chronic conjunctivitis. ( 5602921 )
1967
48
The importance of a polarization microscope in a case of chronic conjunctivitis. ( 5849034 )
1965
49
CHRONIC CONJUNCTIVITIS. ( 14047012 )
1963
50
Paredrine hydrobromide in chronic conjunctivitis. ( 12996629 )
1952

Variations for Chronic Conjunctivitis

Expression for Chronic Conjunctivitis

Search GEO for disease gene expression data for Chronic Conjunctivitis.

Pathways for Chronic Conjunctivitis

Pathways related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CCL11 CCL5 DDX41 FCER2 IL13 IL4
2
Show member pathways
13.47 CCL11 CCL5 FCER2 IL13 IL4 IL5
3
Show member pathways
13.23 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
4
Show member pathways
13.18 CCL11 CCL5 FCER2 IL13 IL4 IL5
5
Show member pathways
13.13 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
6
Show member pathways
12.71 CCL11 IL13 IL4 IL5 RNASE3
7 12.64 IL13 IL4 IL5 PTGER3
8
Show member pathways
12.23 IL13 IL4 IL5 TSLP
9
Show member pathways
12.19 CCL11 IL13 IL4 IL5
10
Show member pathways
12 IL13 IL4 IL5
11 11.85 CCL11 FCER2 IL13 IL4
12 11.76 FCER2 IL4 IL5
13 11.67 IL13 IL4 IL5
14 11.66 IL13 IL4 IL5 TSLP
15 11.5 CCL11 FCER2 IL4 IL5
16 11.36 CCL5 FCER2 IL13 IL4
17 11.16 IL13 IL4 IL5
18 11.14 IL4 IL5
19 11.13 IL13 IL4 IL5 TSLP
20 11.02 CCL11 IL13 IL4 IL5 TNFSF4
21 10.97 IL13 IL4 IL5 TNFSF4
22 10.9 CCL11 CCL5 CMA1 IL13 IL4 IL5
23 10.86 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
24 10.86 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
25 10.69 IL13 IL4 IL5

GO Terms for Chronic Conjunctivitis

Cellular components related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CCL11 CCL5 IL13 IL4 IL5 RNASE3
2 extracellular region GO:0005576 9.28 CCL11 CCL5 CMA1 FCER2 IL13 IL4

Biological processes related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CCL11 CCL5 IL13 IL5
2 chemotaxis GO:0006935 9.7 CCL11 CCL5 IL4
3 response to virus GO:0009615 9.65 CCL11 CCL5 TNFSF4
4 immune response GO:0006955 9.63 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 CCL5 IL13 TSLP
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL13 IL4
7 positive regulation of interleukin-10 production GO:0032733 9.54 TNFSF4 TSLP
8 positive regulation of T cell proliferation GO:0042102 9.54 CCL5 IL4 TNFSF4
9 positive regulation of JAK-STAT cascade GO:0046427 9.51 CCL5 IL5
10 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
11 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL5 TNFSF4
12 eosinophil chemotaxis GO:0048245 9.43 CCL11 CCL5
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.26 IL13 IL4
14 regulation of receptor activity GO:0010469 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
15 positive regulation of interleukin-13 production GO:0032736 9.13 IL4 TNFSF4 TSLP

Molecular functions related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Chronic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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