MCID: CHR087
MIFTS: 37

Chronic Cystitis malady

Nephrological diseases category
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Summaries for Chronic Cystitis

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MalaCards based summary: Chronic Cystitis is related to cystitis and urticaria. An important gene associated with Chronic Cystitis is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. The compounds imatinib and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and pituitary, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Chronic Cystitis

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Chronic Cystitis, Aliases & Descriptions:

Name: Chronic Cystitis 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:1680
ICD9CM27 595.2

Related Diseases for Chronic Cystitis

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Diseases in the Cystitis family:

Acute Cystitis chronic cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cystitis31.5NGF
2urticaria10.3PTGS1
3rhinitis10.2PTGS1
4urethritis10.2
5prostatitis10.2
6vesicoureteral reflux10.0
7cellulitis10.0
8chronic pyelonephritis10.0
9pyelonephritis10.0
10malakoplakia10.0
11factor vii deficiency10.0NGF, KIT
12colitis9.8NGF, PTGS1
13asthma9.8NGF, PTGS1
14vascular disease9.8PTGS1, NGF
15glioblastoma9.8NGF, KIT
16leukemia9.6NGF, PTGS1, KIT

Graphical network of diseases related to Chronic Cystitis:



Diseases related to chronic cystitis

Symptoms for Chronic Cystitis

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Drugs & Therapeutics for Chronic Cystitis

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Drug clinical trials:

Search ClinicalTrials for Chronic Cystitis

Search NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

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Anatomical Context for Chronic Cystitis

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MalaCards organs/tissues related to Chronic Cystitis:

32
Prostate, Testes, Pituitary

Animal Models for Chronic Cystitis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Cystitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6KIT, PTGS1, NGF
2MP:00107718.6NGF, PTGS1, KIT
3MP:00053858.5KIT, PTGS1, NGF
4MP:00053788.5KIT, PTGS1, NGF
5MP:00053868.4NGF, PTGS1, KIT
6MP:00036318.2KIT, PTGS1, NGF

Publications for Chronic Cystitis

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Articles related to Chronic Cystitis:

(show all 37)
idTitleAuthorsYear
1
Microcirculation and structural reorganization of the bladder mucosa in chronic cystitis under conditions of ozone therapy. (24771385)
2014
2
Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23379983)
2013
3
Intravesical glycosaminoglycans in the management of chronic cystitis. (24091478)
2013
4
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. (23806407)
2013
5
Editorial comment to interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23360376)
2013
6
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. (23737602)
2013
7
Intravesical hyaluronidase causes chronic cystitis in a rat model: A potential model of bladder pain syndrome/interstitial cystitis. (24286489)
2013
8
Reinforcements arrive for the war against chronic cystitis and bladder cancer. (22882427)
2012
9
Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. (20079809)
2010
10
CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. (17149610)
2007
11
Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog. (17966335)
2007
12
Intravesical vaccination against Helicobacter pylori in patients with chronic cystitis may confer protection against MALT-type lymphoma of the bladder. (17825999)
2007
13
The effect of chronic inflammatory condition of the bladder and estrogen replacement therapy on bladder functions and histology in surgically menopause and chronic cystitis induced rats. (16267856)
2006
14
A case of cannabinoid rotation in a young woman with chronic cystitis. (12565180)
2003
15
Biosynthetic reactions and ultrastructure of urothelial cells in chronic cystitis and cystopathies. (12512008)
2002
16
Spontaneous bladder rupture due to chronic cystitis 20 years after cystolithotomy. (12444296)
2002
17
Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis. (11312054)
2001
18
Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis. (10754506)
2000
19
Chronic cystitis caused by Corynebacterium urealyticum detected by polymerase chain reaction. (11205634)
2000
20
Intravesical electromotive drug administration for the treatment of non-infectious chronic cystitis. (9449584)
1997
21
Concurrent malakoplakia and primary squamous cell carcinoma arising in long-standing chronic cystitis. (7827859)
1994
22
Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. (2644485)
1989
23
Chronic cystitis: excretion of epidermal growth factor (EGF)/urogastrone (URO). (3499698)
1987
24
The effects of chronic cystitis on vesicoureteral reflux in an animal model. (3510317)
1986
25
A light and electron microscopic study of urothelium from patients with chronic cystitis. (6479201)
1984
26
Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. (6626895)
1983
27
Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia. (7104592)
1982
28
Chronic cystitis: a non-diagnosis. (20469386)
1982
29
Clinicopathological conference: fifty-seven year old male with symptoms of chronic cystitis. (1054887)
1975
30
Treatment of chronic cystitis by instillation: experiments employing an artificial model. (4217003)
1974
31
Clinico-pathological conference: cellulitis, urolithiasis, chronic pyelonephritis, chronic cystitis and chronic prostatitis and cystic hyperplasia in a dog. (5104482)
1971
32
Psychometric testing with the human figure drawing in chronic cystitis. (5532923)
1970
33
Operative treatment of chronic cystitis by urethrotomy: 10 years of experience. (5461833)
1970
34
Functional abnormalities of the bladder in children: characteristics of chronic cystitis and chronic urethritis. (5532922)
1970
35
Surgical treatment of chronic cystitis in a bitch. (5812943)
1969
36
CARCINOMA OF THE BLADDER SIMULATING CHRONIC CYSTITIS. (14269353)
1965
37
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Chronic Cystitis

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Expression for genes affiliated with Chronic Cystitis

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Expression patterns in normal tissues for genes affiliated with Chronic Cystitis

Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for genes affiliated with Chronic Cystitis

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Pathways related to Chronic Cystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1KIT, NGF
2
Show member pathways
9.1KIT, NGF
3
Show member pathways
9.1NGF, KIT
4
Show member pathways
9.1KIT, NGF
5
Show member pathways
9.0PTGS1, NGF
69.0PTGS1, NGF

Compounds for genes affiliated with Chronic Cystitis

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Compounds related to Chronic Cystitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1imatinib44 50 1111.7KIT, PTGS1
2cytarabine44 50 1111.5KIT, NGF
3valine449.5KIT, NGF
4paraffin449.4KIT, PTGS1
55fluorouracil449.4KIT, NGF
6pgj-2449.4PTGS1, NGF
7phosphotyrosine449.4KIT, NGF
8camptothecin44 61 1111.4NGF, PTGS1
9herbimycin a44 6110.4PTGS1, NGF
10choline44 24 1111.4PTGS1, NGF
11prostacyclin449.4NGF, PTGS1
12histamine44 28 2411.4KIT, NGF
13aspirin44 50 28 2412.3NGF, PTGS1
14pd 98,059449.3KIT, NGF
15aspartate449.3KIT, PTGS1
16indomethacin44 28 61 1112.3PTGS1, NGF
17vitamin d449.3NGF, PTGS1
18phosphoinositide449.3KIT, NGF
19nmda44 2810.3PTGS1, NGF
20lactate449.2KIT, PTGS1
21ly294002449.2NGF, PTGS1
22glutamine449.1NGF, KIT
23genistein44 28 61 2 24 1114.1PTGS1, NGF
24actinomycin d448.9KIT, PTGS1, NGF
25cycloheximide448.9KIT, PTGS1, NGF
26vegf448.9NGF, PTGS1, KIT
27cysteine448.9KIT, PTGS1, NGF
28thymidine44 249.8KIT, NGF
29serine448.8KIT, PTGS1, NGF

GO Terms for genes affiliated with Chronic Cystitis

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Biological processes related to Chronic Cystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:0421279.4KIT, PTGS1
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2KIT, NGF
3phosphatidylinositol-mediated signalingGO:0480159.1KIT, NGF
4inflammatory responseGO:0069549.1KIT, NGF
5positive regulation of gene expressionGO:0106289.0NGF, KIT
6neurotrophin TRK receptor signaling pathwayGO:0480118.8KIT, NGF

Products for genes affiliated with Chronic Cystitis

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Sources for Chronic Cystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet