MCID: CHR087
MIFTS: 37

Chronic Cystitis malady

Nephrological diseases category
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Summaries for Chronic Cystitis

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33MalaCards
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MalaCards: Chronic Cystitis is related to cystitis and urethritis. An important gene associated with Chronic Cystitis is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. The compounds imatinib and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and pituitary, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Chronic Cystitis

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

chronic cystitis 8 45 62


External Ids:

Disease Ontology8 DOID:1680
ICD9CM27 595.2

Related Diseases for Chronic Cystitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cystitis family:

Acute Cystitis chronic cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cystitis31.3NGF
2urethritis10.2
3prostatitis10.2
4urticaria10.1PTGS1
5rhinitis10.1PTGS1
6vesicoureteral reflux10.0
7cellulitis10.0
8chronic pyelonephritis10.0
9pyelonephritis10.0
10malakoplakia10.0
11paine syndrome10.0
12factor vii deficiency10.0NGF, KIT
13asthma10.0NGF, PTGS1
14vascular disease9.9PTGS1, NGF
15glioblastoma multiforme9.9NGF, KIT
16leukemia9.9NGF, PTGS1, KIT

Graphical network of diseases related to Chronic Cystitis:



Diseases related to chronic cystitis

Symptoms for Chronic Cystitis

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Drugs & Therapeutics for Chronic Cystitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Chronic Cystitis

Search NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

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Anatomical Context for Chronic Cystitis

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33MalaCards
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MalaCards organs/tissues related to Chronic Cystitis:

33
Prostate, Testes, Pituitary

Animal Models for Chronic Cystitis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Chronic Cystitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6KIT, PTGS1, NGF
2MP:00107718.6NGF, PTGS1, KIT
3MP:00053858.5KIT, PTGS1, NGF
4MP:00053788.5KIT, PTGS1, NGF
5MP:00053868.4NGF, PTGS1, KIT
6MP:00036318.2KIT, PTGS1, NGF

Publications for Chronic Cystitis

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Sources:
52PubMed
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Articles related to Chronic Cystitis:

(show all 35)
idTitleAuthorsYear
1
Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23379983)
2013
2
Intravesical glycosaminoglycans in the management of chronic cystitis. (24091478)
2013
3
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. (23806407)
2013
4
Editorial comment to interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23360376)
2013
5
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. (23737602)
2013
6
Intravesical hyaluronidase causes chronic cystitis in a rat model: A potential model of bladder pain syndrome/interstitial cystitis. (24286489)
2013
7
Reinforcements arrive for the war against chronic cystitis and bladder cancer. (22882427)
2012
8
Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. (20079809)
2010
9
CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. (17149610)
2007
10
Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog. (17966335)
2007
11
The effect of chronic inflammatory condition of the bladder and estrogen replacement therapy on bladder functions and histology in surgically menopause and chronic cystitis induced rats. (16267856)
2006
12
A case of cannabinoid rotation in a young woman with chronic cystitis. (12565180)
2003
13
Biosynthetic reactions and ultrastructure of urothelial cells in chronic cystitis and cystopathies. (12512008)
2002
14
Spontaneous bladder rupture due to chronic cystitis 20 years after cystolithotomy. (12444296)
2002
15
Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis. (11312054)
2001
16
Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis. (10754506)
2000
17
Chronic cystitis caused by Corynebacterium urealyticum detected by polymerase chain reaction. (11205634)
2000
18
Intravesical electromotive drug administration for the treatment of non-infectious chronic cystitis. (9449584)
1997
19
Concurrent malakoplakia and primary squamous cell carcinoma arising in long-standing chronic cystitis. (7827859)
1994
20
Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. (2644485)
1989
21
Chronic cystitis: excretion of epidermal growth factor (EGF)/urogastrone (URO). (3499698)
1987
22
The effects of chronic cystitis on vesicoureteral reflux in an animal model. (3510317)
1986
23
A light and electron microscopic study of urothelium from patients with chronic cystitis. (6479201)
1984
24
Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. (6626895)
1983
25
Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia. (7104592)
1982
26
Chronic cystitis: a non-diagnosis. (20469386)
1982
27
Clinicopathological conference: fifty-seven year old male with symptoms of chronic cystitis. (1054887)
1975
28
Treatment of chronic cystitis by instillation: experiments employing an artificial model. (4217003)
1974
29
Clinico-pathological conference: cellulitis, urolithiasis, chronic pyelonephritis, chronic cystitis and chronic prostatitis and cystic hyperplasia in a dog. (5104482)
1971
30
Psychometric testing with the human figure drawing in chronic cystitis. (5532923)
1970
31
Operative treatment of chronic cystitis by urethrotomy: 10 years of experience. (5461833)
1970
32
Functional abnormalities of the bladder in children: characteristics of chronic cystitis and chronic urethritis. (5532922)
1970
33
Surgical treatment of chronic cystitis in a bitch. (5812943)
1969
34
CARCINOMA OF THE BLADDER SIMULATING CHRONIC CYSTITIS. (14269353)
1965
35
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Chronic Cystitis

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Expression for genes affiliated with Chronic Cystitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Cystitis

Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for genes affiliated with Chronic Cystitis

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Sources:
50PathCards, 30KEGG, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Chronic Cystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1KIT, NGF
2
Show member pathways
9.1KIT, NGF
3
Show member pathways
9.1NGF, KIT
4
Show member pathways
9.1KIT, NGF
5
Show member pathways
9.0PTGS1, NGF
69.0PTGS1, NGF

Compounds for genes affiliated with Chronic Cystitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Chronic Cystitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1imatinib45 51 1111.7KIT, PTGS1
2cytarabine45 51 1111.5KIT, NGF
3valine459.5KIT, NGF
4paraffin459.4KIT, PTGS1
55fluorouracil459.4KIT, NGF
6pgj-2459.4PTGS1, NGF
7phosphotyrosine459.4KIT, NGF
8camptothecin45 61 1111.4NGF, PTGS1
9herbimycin a45 6110.4PTGS1, NGF
10choline45 24 1111.4PTGS1, NGF
11prostacyclin459.4NGF, PTGS1
12histamine45 29 2411.4KIT, NGF
13aspirin45 51 29 2412.3NGF, PTGS1
14pd 98,059459.3KIT, NGF
15aspartate459.3KIT, PTGS1
16indomethacin45 29 61 1112.3PTGS1, NGF
17vitamin d459.3NGF, PTGS1
18phosphoinositide459.3KIT, NGF
19nmda45 2910.3PTGS1, NGF
20lactate459.2KIT, PTGS1
21ly294002459.2NGF, PTGS1
22glutamine459.1NGF, KIT
23genistein45 29 61 3 24 1114.1PTGS1, NGF
24actinomycin d458.9KIT, PTGS1, NGF
25cycloheximide458.9KIT, PTGS1, NGF
26vegf458.9NGF, PTGS1, KIT
27cysteine458.9KIT, PTGS1, NGF
28thymidine45 249.8KIT, NGF
29serine458.8KIT, PTGS1, NGF

GO Terms for genes affiliated with Chronic Cystitis

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Sources:
16Gene Ontology
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Biological processes related to Chronic Cystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:0421279.4KIT, PTGS1
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2KIT, NGF
3phosphatidylinositol-mediated signalingGO:0480159.1KIT, NGF
4inflammatory responseGO:0069549.1KIT, NGF
5positive regulation of gene expressionGO:0106289.0NGF, KIT
6neurotrophin TRK receptor signaling pathwayGO:0480118.8KIT, NGF

Products for genes affiliated with Chronic Cystitis

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Sources for Chronic Cystitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet