MCID: CHR087
MIFTS: 31

Chronic Cystitis malady

Nephrological diseases category

Summaries for Chronic Cystitis

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MalaCards based summary: Chronic Cystitis is related to cystitis and urticaria. An important gene associated with Chronic Cystitis is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. The compounds imatinib and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include prostate and testes, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Chronic Cystitis

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Chronic Cystitis, Aliases & Descriptions:

Name: Chronic Cystitis 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:1680
ICD9CM27 595.2

Related Diseases for Chronic Cystitis

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Diseases in the Cystitis family:

Acute Cystitis chronic cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1cystitis31.5NGF
2urticaria10.3PTGS1
3rhinitis10.2PTGS1
4urethritis10.2
5prostatitis10.2
6vesicoureteral reflux10.0
7cellulitis10.0
8chronic pyelonephritis10.0
9pyelonephritis10.0
10adenomyosis10.0
11malakoplakia10.0
12factor vii deficiency9.9NGF, KIT
13colitis9.8NGF, PTGS1
14asthma9.8NGF, PTGS1
15vascular disease9.8PTGS1, NGF
16glioblastoma9.7NGF, KIT
17leukemia9.6NGF, PTGS1, KIT

Graphical network of diseases related to Chronic Cystitis:



Diseases related to chronic cystitis

Symptoms for Chronic Cystitis

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Drugs & Therapeutics for Chronic Cystitis

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Drug clinical trials:

Search ClinicalTrials for Chronic Cystitis

Search NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

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Anatomical Context for Chronic Cystitis

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MalaCards organs/tissues related to Chronic Cystitis:

31
Prostate, Testes

Animal Models for Chronic Cystitis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Cystitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6KIT, PTGS1, NGF
2MP:00107718.6NGF, PTGS1, KIT
3MP:00053858.5KIT, PTGS1, NGF
4MP:00053788.5KIT, PTGS1, NGF
5MP:00053868.4NGF, PTGS1, KIT
6MP:00036318.2KIT, PTGS1, NGF

Publications for Chronic Cystitis

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Articles related to Chronic Cystitis:

(show all 39)
idTitleAuthorsYear
1
Structural and Functional Basis of Chronic Pelvic Pain Syndrome during Combined Chronic Cystitis and Adenomyosis. (25896591)
2015
2
A novel method for assessing bladder-related pain reveals the involvement of nerve growth factor in pain associated with cyclophosphamide-induced chronic cystitis in mice. (25820250)
2015
3
Microcirculation and structural reorganization of the bladder mucosa in chronic cystitis under conditions of ozone therapy. (24771385)
2014
4
Re: a FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. (25629130)
2014
5
Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23379983)
2013
6
Intravesical glycosaminoglycans in the management of chronic cystitis. (24091478)
2013
7
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. (23806407)
2013
8
Editorial comment to interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23360376)
2013
9
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. (23737602)
2013
10
Intravesical hyaluronidase causes chronic cystitis in a rat model: A potential model of bladder pain syndrome/interstitial cystitis. (24286489)
2013
11
Reinforcements arrive for the war against chronic cystitis and bladder cancer. (22882427)
2012
12
Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. (20079809)
2010
13
CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. (17149610)
2007
14
Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog. (17966335)
2007
15
Intravesical vaccination against Helicobacter pylori in patients with chronic cystitis may confer protection against MALT-type lymphoma of the bladder. (17825999)
2007
16
The effect of chronic inflammatory condition of the bladder and estrogen replacement therapy on bladder functions and histology in surgically menopause and chronic cystitis induced rats. (16267856)
2006
17
A case of cannabinoid rotation in a young woman with chronic cystitis. (12565180)
2003
18
Biosynthetic reactions and ultrastructure of urothelial cells in chronic cystitis and cystopathies. (12512008)
2002
19
Spontaneous bladder rupture due to chronic cystitis 20 years after cystolithotomy. (12444296)
2002
20
Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis. (11312054)
2001
21
Chronic cystitis caused by Corynebacterium urealyticum detected by polymerase chain reaction. (11205634)
2000
22
Intravesical electromotive drug administration for the treatment of non-infectious chronic cystitis. (9449584)
1997
23
Concurrent malakoplakia and primary squamous cell carcinoma arising in long-standing chronic cystitis. (7827859)
1994
24
Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. (2644485)
1989
25
Chronic cystitis: excretion of epidermal growth factor (EGF)/urogastrone (URO). (3499698)
1987
26
The effects of chronic cystitis on vesicoureteral reflux in an animal model. (3510317)
1986
27
A light and electron microscopic study of urothelium from patients with chronic cystitis. (6479201)
1984
28
Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. (6626895)
1983
29
Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia. (7104592)
1982
30
Chronic cystitis: a non-diagnosis. (20469386)
1982
31
Clinicopathological conference: fifty-seven year old male with symptoms of chronic cystitis. (1054887)
1975
32
Treatment of chronic cystitis by instillation: experiments employing an artificial model. (4217003)
1974
33
Clinico-pathological conference: cellulitis, urolithiasis, chronic pyelonephritis, chronic cystitis and chronic prostatitis and cystic hyperplasia in a dog. (5104482)
1971
34
Psychometric testing with the human figure drawing in chronic cystitis. (5532923)
1970
35
Operative treatment of chronic cystitis by urethrotomy: 10 years of experience. (5461833)
1970
36
Functional abnormalities of the bladder in children: characteristics of chronic cystitis and chronic urethritis. (5532922)
1970
37
Surgical treatment of chronic cystitis in a bitch. (5812943)
1969
38
CARCINOMA OF THE BLADDER SIMULATING CHRONIC CYSTITIS. (14269353)
1965
39
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Chronic Cystitis

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Expression for genes affiliated with Chronic Cystitis

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Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for genes affiliated with Chronic Cystitis

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Pathways related to Chronic Cystitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1KIT, NGF
2
Show member pathways
9.1KIT, NGF
3
Show member pathways
9.1NGF, KIT
4
Show member pathways
9.1KIT, NGF
5
Show member pathways
9.0PTGS1, NGF
69.0PTGS1, NGF

Compounds for genes affiliated with Chronic Cystitis

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Compounds related to Chronic Cystitis according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1imatinib43 49 1211.7KIT, PTGS1
2cytarabine43 49 1211.5KIT, NGF
3valine439.5KIT, NGF
4paraffin439.4KIT, PTGS1
55fluorouracil439.4KIT, NGF
6pgj-2439.4PTGS1, NGF
7phosphotyrosine439.4KIT, NGF
8camptothecin43 59 1211.4NGF, PTGS1
9herbimycin a43 5910.4PTGS1, NGF
10choline43 24 1211.4PTGS1, NGF
11prostacyclin439.4NGF, PTGS1
12histamine43 28 2411.4KIT, NGF
13aspirin43 49 28 2412.3NGF, PTGS1
14pd 98,059439.3KIT, NGF
15aspartate439.3KIT, PTGS1
16indomethacin43 28 59 1212.3PTGS1, NGF
17vitamin d439.3NGF, PTGS1
18phosphoinositide439.3KIT, NGF
19nmda43 2810.3PTGS1, NGF
20lactate439.2KIT, PTGS1
21ly294002439.2NGF, PTGS1
22glutamine439.1NGF, KIT
23genistein43 28 59 2 24 1214.1PTGS1, NGF
24actinomycin d438.9KIT, PTGS1, NGF
25cycloheximide438.9KIT, PTGS1, NGF
26vegf438.9NGF, PTGS1, KIT
27cysteine438.9KIT, PTGS1, NGF
28thymidine43 249.8KIT, NGF
29serine438.8KIT, PTGS1, NGF

GO Terms for genes affiliated with Chronic Cystitis

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Biological processes related to Chronic Cystitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:00421279.4KIT, PTGS1
2positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2KIT, NGF
3phosphatidylinositol-mediated signalingGO:00480159.1KIT, NGF
4inflammatory responseGO:00069549.1KIT, NGF
5positive regulation of gene expressionGO:00106289.0NGF, KIT
6neurotrophin TRK receptor signaling pathwayGO:00480118.8KIT, NGF

Products for genes affiliated with Chronic Cystitis

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Sources for Chronic Cystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet