MCID: CHR087
MIFTS: 34

Chronic Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Cystitis

MalaCards integrated aliases for Chronic Cystitis:

Name: Chronic Cystitis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1680
ICD10 33 N30.2
ICD9CM 35 595.2
UMLS 69 C0156268

Summaries for Chronic Cystitis

MalaCards based summary : Chronic Cystitis is related to sensory system cancer and lung occult small cell carcinoma. An important gene associated with Chronic Cystitis is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Neuroscience and Celecoxib Pathway, Pharmacodynamics. The drugs Acetylcholine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and pituitary.

Related Diseases for Chronic Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 sensory system cancer 10.5 CDX2 KRT20
2 lung occult small cell carcinoma 10.5 CDX2 KRT20
3 fibroepithelial polyp of urethra 10.5 CDX2 KRT20
4 chronic neutrophilic leukemia 10.5 CDX2 KRT20
5 gastric adenocarcinoma 10.5 CDX2 KRT20
6 childhood teratoma of the ovary 10.5 CDX2 KRT20
7 intrahepatic cholangiocarcinoma 10.5 CDX2 KRT20
8 giant cell tumor 10.5 CDX2 KRT20
9 ovarian melanoma 10.5 CDX2 KRT20
10 tabes dorsalis 10.5 CDX2 KRT20
11 stricture or kinking of ureter 10.5 CDX2 KRT20
12 fibroma 10.4 CDX2 KRT20
13 anemia of prematurity 10.4 CDX2 KRT20
14 uterine corpus adenofibroma 10.4 CDX2 KRT20
15 brain ependymoma 10.4 PTGS1 PTGS2
16 ovarian remnant syndrome 10.4 PTGS1 PTGS2
17 mesenchymoma 10.4 CDX2 KRT20
18 wissler's syndrome 10.4 CDX2 KRT20
19 adenosine monophosphate deaminase 1 deficiency 10.4 NGF PTGS2
20 human t-cell leukemia virus type 1 10.4 CDX2 KRT20
21 vulva squamous cell carcinoma 10.4 KRT20 UPK3A
22 spastic ataxia 3 10.4 CDX2 KRT20
23 migraine with aura 10.4 CDX2 KRT20
24 childhood ovarian endodermal sinus tumor 10.4 CDX2 KRT20
25 cavernous sinus thrombosis 10.4 CDX2 KRT20
26 breast secretory carcinoma 10.4 KRT20 UPK3A
27 prostate small cell carcinoma 10.4 CDX2 KRT20
28 pacinian tumor 10.4 CDX2 KRT20
29 postpoliomyelitis syndrome 10.4 CDX2 KRT20
30 cervicitis 10.4 PTGS1 PTGS2
31 cystitis 10.4
32 pancreatic signet ring cell adenocarcinoma 10.4 CDX2 KRT20
33 pulmonary artery hypoplasia 10.3 PTGS1 PTGS2
34 breast mucinous carcinoma 10.3 CDX2 KRT20
35 cushing's syndrome 10.3 CDX2 PTGS2
36 optic papillitis 10.3 CDX2 KRT20
37 bardet-biedl syndrome 17 10.3 PTGS1 PTGS2
38 microcystic meningioma 10.3 CDX2 KRT20
39 cecum adenocarcinoma 10.3 CDX2 KRT20
40 villous adenocarcinoma 10.3 CDX2 PTGS2
41 congenital leptin deficiency 10.3 PPIG PTGS2
42 perivascular epithelioid cell tumor 10.2 KRT20 UPK3A
43 uterine corpus dissecting leiomyoma 10.2 NGF UPK3A
44 tibialis tendinitis 10.2 PTGS1 PTGS2
45 frontal sinus schneiderian papilloma 10.2 CDX2 PTGS2
46 gastrointestinal neuroendocrine tumor 10.1 CDX2 PTGS2
47 fibrosarcomatous osteosarcoma 10.1 PTGS1 PTGS2
48 maxillary neoplasm 10.1 CDX2 PTGS2
49 brain glioblastoma multiforme 10.1 NGF PPIG UPK3A
50 fasciolopsiasis 10.1 KRT20 PTGS2

Graphical network of the top 20 diseases related to Chronic Cystitis:



Diseases related to Chronic Cystitis

Symptoms & Phenotypes for Chronic Cystitis

Drugs & Therapeutics for Chronic Cystitis

Drugs for Chronic Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cycloserine Approved Phase 4 68-41-7 401 6234
4
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
5
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
6
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
10 abobotulinumtoxinA Phase 4
11 Botulinum Toxins Phase 4
12 Botulinum Toxins, Type A Phase 4
13 Cholinergic Agents Phase 4
14 Neuromuscular Agents Phase 4
15 Neurotransmitter Agents Phase 4,Phase 3
16 onabotulinumtoxinA Phase 4
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
18 Anti-Bacterial Agents Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Anti-Infective Agents Phase 4
21 Antimetabolites Phase 4
22 Antitubercular Agents Phase 4
23 Renal Agents Phase 4
24 Adrenergic Agents Phase 4,Phase 3
25 Adrenergic Agonists Phase 4
26 Adrenergic alpha-2 Receptor Agonists Phase 4
27 Adrenergic alpha-Agonists Phase 4
28 Analgesics Phase 4,Phase 3
29 Analgesics, Non-Narcotic Phase 4,Phase 3
30 Anti-Anxiety Agents Phase 4
31 Central Nervous System Depressants Phase 4,Phase 3
32 Hypnotics and Sedatives Phase 4
33 Oxytocics Phase 4
34 Psychotropic Drugs Phase 4,Phase 3
35 Tranquilizing Agents Phase 4,Phase 3
36 Adrenergic Antagonists Phase 4
37 Adrenergic beta-1 Receptor Antagonists Phase 4
38 Adrenergic beta-Antagonists Phase 4
39 Anti-Arrhythmia Agents Phase 4
40 Antihypertensive Agents Phase 4
41 Autonomic Agents Phase 4
42 Sympatholytics Phase 4
43 Contraceptive Agents Phase 4
44 Contraceptives, Oral Phase 4
45 Contraceptives, Oral, Combined Phase 4
46 Hormones Phase 4,Phase 2
47 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination Phase 4
48 Norinyl Phase 4
49 Anticonvulsants Phase 4
50 Antimanic Agents Phase 4

Interventional clinical trials:

(show all 50)

id Name Status NCT ID Phase Drugs
1 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4 Botox
2 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
3 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
4 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
5 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Oral Tablet;Placebo Oral Tablet
6 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
7 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
8 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
9 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
10 Efficacy Study of Adalimumab to Treat Interstitial Cystitis Completed NCT01295814 Phase 3 Adalimumab
11 Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS) Completed NCT00124306 Phase 3 Amitriptyline
12 Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome Recruiting NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
13 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
14 Total Body Irradiation/Fludarabine Based Ablative Haploidentical Transplant for Hematologic Diseases Completed NCT01336712 Phase 2
15 Bladder Directed vs. Pelvic Floor Therapy in IC/BPS Recruiting NCT02870738 Phase 2 Bladder Instillations
16 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
17 A Study to Evaluate the Pain Relieving Effects, Safety, and Tolerability of JNJ-42160443 for the Relief of Bladder Pain Terminated NCT01060254 Phase 2 Placebo;JNJ-42160443
18 A Safety, Tolerability and Preliminary Efficacy Study of LiRIS® 400 mg in Women With Interstitial Cystitis (IC) and Hunner's Lesions Completed NCT01879683 Phase 1 LiRIS® 400 mg
19 Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected Completed NCT01030640 Phase 1
20 Platelet-Rich Plasma (PRP) Injection in Treatment of Interstitial Cystitis Not yet recruiting NCT03104361 Phase 1
21 Female Chronic Pelvic Pain Unknown status NCT01255345
22 Comparative Study Between Hyperbaric Therapy and Intravesical Dimethyl Sulfoxide Instillation for Interstitial Cystitis Unknown status NCT01069263 DMSO
23 Chronic Pelvic Pain Study of Individuals With Diagnoses or Symptoms of Interstitial Cystitis and/ or Chronic Prostatitis Completed NCT01098279
24 Assessing Chronic Pain Conditions in Patients (Pts) With and Without (w&wo) Interstitial Cystitis Completed NCT01138800
25 Linkage Analysis in Interstitial Cystitis Completed NCT00675298
26 Diagnostic Challenges in IC (and Male CPPS) Completed NCT00672087
27 Observational Study of Control Participants for the MAPP Research Network Completed NCT01098292
28 Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain Completed NCT00554320
29 Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome Completed NCT00810329
30 Clinical Features and Histologic Findings in Bladder Pain Syndrome/Interstitial Cystitis Completed NCT03069053
31 Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC. Completed NCT00775281
32 Urinary Biomarkers Characteristic to Interstitial Cystitis Completed NCT00971568
33 Intravesical Liposomes for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) Completed NCT01731470
34 Physical Therapy Trial for Pelvic Pain Completed NCT00434343
35 Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine Completed NCT00740233
36 Life-Stress Interview for Women With Chronic Urogenital Pain Conditions Completed NCT02286115
37 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
38 Impact of Comorbidities Among Adolescents Infected Pain Associated With Disorders of the Masticatory System Completed NCT02771847
39 Genetic Studies in Interstitial Cystitis (IC) Recruiting NCT00389142
40 Trans-MAPP II Study of Urologic Chronic Pelvin Pain Recruiting NCT02898220
41 Microbiomes of Pelvic Pain Recruiting NCT01738464
42 Guided Imagery and Transcranial Direct Current Stimulation (tDCS) in Women With Chronic Pelvic Pain Recruiting NCT02781103
43 The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study) Recruiting NCT02331472
44 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder Recruiting NCT03143920 Early Phase 1
45 Trans-MAPP Symptom Patterns Study (SPS) Recruiting NCT02514265
46 Use of Preemptive Pudendal Nerve Block Prior to Hydrodistention for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) Recruiting NCT02517996 Lidocaine;Placebo
47 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
48 Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Recruiting NCT00499317
49 Treatment of Interstitial Cystitis/Painful Bladder Syndrome Using Alternative Techniques: Exercise, Meditation, Tai Chi Terminated NCT00661050
50 Microbiome of Urologic Chronic Pelvic Pain Syndrome Withdrawn NCT03027076

Search NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

Anatomical Context for Chronic Cystitis

MalaCards organs/tissues related to Chronic Cystitis:

39
Prostate, Skin, Pituitary, Testes

Publications for Chronic Cystitis

Articles related to Chronic Cystitis:

(show all 43)
id Title Authors Year
1
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. ( 26685753 )
2015
2
Structural and Functional Basis of Chronic Pelvic Pain Syndrome during Combined Chronic Cystitis and Adenomyosis. ( 25896591 )
2015
3
Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh. ( 26516891 )
2015
4
A novel method for assessing bladder-related pain reveals the involvement of nerve growth factor in pain associated with cyclophosphamide-induced chronic cystitis in mice. ( 25820250 )
2015
5
Chronic Cystitis Associated With Keratinizing Squamous Metaplasia Progressing to Squamous Papilloma. ( 26955553 )
2014
6
Re: a FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. ( 25629130 )
2014
7
Microcirculation and structural reorganization of the bladder mucosa in chronic cystitis under conditions of ozone therapy. ( 24771385 )
2014
8
Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. ( 23379983 )
2013
9
Editorial comment to interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. ( 23360376 )
2013
10
Intravesical glycosaminoglycans in the management of chronic cystitis. ( 24091478 )
2013
11
Intravesical hyaluronidase causes chronic cystitis in a rat model: A potential model of bladder pain syndrome/interstitial cystitis. ( 24286489 )
2013
12
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. ( 23806407 )
2013
13
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. ( 23737602 )
2013
14
Reinforcements arrive for the war against chronic cystitis and bladder cancer. ( 22882427 )
2012
15
Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. ( 20079809 )
2010
16
Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog. ( 17966335 )
2007
17
CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. ( 17149610 )
2007
18
Intravesical vaccination against Helicobacter pylori in patients with chronic cystitis may confer protection against MALT-type lymphoma of the bladder. ( 17825999 )
2007
19
The effect of chronic inflammatory condition of the bladder and estrogen replacement therapy on bladder functions and histology in surgically menopause and chronic cystitis induced rats. ( 16267856 )
2006
20
A case of cannabinoid rotation in a young woman with chronic cystitis. ( 12565180 )
2003
21
Spontaneous bladder rupture due to chronic cystitis 20 years after cystolithotomy. ( 12444296 )
2002
22
Biosynthetic reactions and ultrastructure of urothelial cells in chronic cystitis and cystopathies. ( 12512008 )
2002
23
Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis. ( 11312054 )
2001
24
Chronic cystitis caused by Corynebacterium urealyticum detected by polymerase chain reaction. ( 11205634 )
2000
25
Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis. ( 10754506 )
2000
26
Intravesical electromotive drug administration for the treatment of non-infectious chronic cystitis. ( 9449584 )
1997
27
Concurrent malakoplakia and primary squamous cell carcinoma arising in long-standing chronic cystitis. ( 7827859 )
1994
28
Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. ( 2644485 )
1989
29
Chronic cystitis: excretion of epidermal growth factor (EGF)/urogastrone (URO). ( 3499698 )
1987
30
The effects of chronic cystitis on vesicoureteral reflux in an animal model. ( 3510317 )
1986
31
A light and electron microscopic study of urothelium from patients with chronic cystitis. ( 6479201 )
1984
32
Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. ( 6626895 )
1983
33
Chronic cystitis: a non-diagnosis. ( 20469386 )
1982
34
Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia. ( 7104592 )
1982
35
Clinicopathological conference: fifty-seven year old male with symptoms of chronic cystitis. ( 1054887 )
1975
36
Treatment of chronic cystitis by instillation: experiments employing an artificial model. ( 4217003 )
1974
37
Clinico-pathological conference: cellulitis, urolithiasis, chronic pyelonephritis, chronic cystitis and chronic prostatitis and cystic hyperplasia in a dog. ( 5104482 )
1971
38
Psychometric testing with the human figure drawing in chronic cystitis. ( 5532923 )
1970
39
Operative treatment of chronic cystitis by urethrotomy: 10 years of experience. ( 5461833 )
1970
40
Functional abnormalities of the bladder in children: characteristics of chronic cystitis and chronic urethritis. ( 5532922 )
1970
41
Surgical treatment of chronic cystitis in a bitch. ( 5812943 )
1969
42
CARCINOMA OF THE BLADDER SIMULATING CHRONIC CYSTITIS. ( 14269353 )
1965
43
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. ( 20750395 )
1882

Variations for Chronic Cystitis

Expression for Chronic Cystitis

Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for Chronic Cystitis

GO Terms for Chronic Cystitis

Biological processes related to Chronic Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of neuron differentiation GO:0045664 9.26 NGF NTF4
2 prostaglandin metabolic process GO:0006693 9.16 PTGS1 PTGS2
3 prostaglandin biosynthetic process GO:0001516 8.96 PTGS1 PTGS2
4 cyclooxygenase pathway GO:0019371 8.62 PTGS1 PTGS2

Molecular functions related to Chronic Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 PTGS1 PTGS2
2 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Chronic Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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